NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|387763613|ref|NP_001248384|]
View 

chemerin-like receptor 2 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 11606833)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
39-315 7.99e-152

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


:

Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 428.39  E-value: 7.99e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQ 118
Cdd:cd15119    1 IVSIVIYIVAFVLGVPGNAIVIWVTGFKWKKTVNTLWFLNLAIADFVFVLFLPLHITYVALDFHWPFGVWLCKINSFVAV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEF-NNHTLCYNNFQKHDPD 197
Cdd:cd15119   81 LNMFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALYFRDTMELsINVTICFNNFHKHDGD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 LTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSY 277
Cdd:cd15119  161 LIVMRHTILVWVRFFFGFLFPLLTMVVCYSLLAIKVKRRTLLISSKFFWTISAVIVAFFVCWTPYHIFSILELSIHHSSY 240
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 387763613 278 SHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15119  241 LHNVLRAGIPLATSLAFINSCLNPILYVLIGKKFKAHL 278
 
Name Accession Description Interval E-value
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
39-315 7.99e-152

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 428.39  E-value: 7.99e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQ 118
Cdd:cd15119    1 IVSIVIYIVAFVLGVPGNAIVIWVTGFKWKKTVNTLWFLNLAIADFVFVLFLPLHITYVALDFHWPFGVWLCKINSFVAV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEF-NNHTLCYNNFQKHDPD 197
Cdd:cd15119   81 LNMFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALYFRDTMELsINVTICFNNFHKHDGD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 LTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSY 277
Cdd:cd15119  161 LIVMRHTILVWVRFFFGFLFPLLTMVVCYSLLAIKVKRRTLLISSKFFWTISAVIVAFFVCWTPYHIFSILELSIHHSSY 240
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 387763613 278 SHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15119  241 LHNVLRAGIPLATSLAFINSCLNPILYVLIGKKFKAHL 278
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
55-304 2.61e-44

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 152.84  E-value: 2.61e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613   55 GNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVIS 132
Cdd:pfam00001   1 GNLLVILvILRNKKLRTPTNIFLLNLAVADLLFSLLtLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  133 LDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDT--VEFNNHTLCYNnfqkhDPDLTLIRHHVLTWVK 210
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTltVPEGNVTVCFI-----DFPEDLSKPVSYTLLI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  211 FIIGYLFPLLTMSICYLCLIFKVKKRSILISS--------RHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYSHHVM 282
Cdd:pfam00001 156 SVLGFLLPLLVILVCYTLIIRTLRKSASKQKSsertqrrrKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLLD 235
                         250       260
                  ....*....|....*....|..
gi 387763613  283 QAgIPLSTGLAFLNSCLNPILY 304
Cdd:pfam00001 236 KA-LSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
43-319 8.86e-28

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 111.02  E-value: 8.86e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMnFHWPFGIWLCKANSFTAQLNMF 122
Cdd:PHA03087  45 VVYSTIFFFGLVGNIIVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYIL-FQWSFGEFACKIVSGLYYIGFY 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLir 202
Cdd:PHA03087 124 NSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNKTMNWKL-- 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 203 hhvltWVKF---IIGYLFPLLTMSICYLCLIFKVKKRSILISS-RHFWTILVVVVAFVVCWTPYH----LFSIWELTIHH 274
Cdd:PHA03087 202 -----FINFeinIIGMLIPLTILLYCYSKILITLKGINKSKKNkKAIKLVLIIVILFVIFWLPFNvsvfVYSLHILHFKS 276
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 387763613 275 NSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARFRSSV 319
Cdd:PHA03087 277 GCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSL 321
 
Name Accession Description Interval E-value
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
39-315 7.99e-152

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 428.39  E-value: 7.99e-152
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQ 118
Cdd:cd15119    1 IVSIVIYIVAFVLGVPGNAIVIWVTGFKWKKTVNTLWFLNLAIADFVFVLFLPLHITYVALDFHWPFGVWLCKINSFVAV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEF-NNHTLCYNNFQKHDPD 197
Cdd:cd15119   81 LNMFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALYFRDTMELsINVTICFNNFHKHDGD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 LTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSY 277
Cdd:cd15119  161 LIVMRHTILVWVRFFFGFLFPLLTMVVCYSLLAIKVKRRTLLISSKFFWTISAVIVAFFVCWTPYHIFSILELSIHHSSY 240
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 387763613 278 SHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15119  241 LHNVLRAGIPLATSLAFINSCLNPILYVLIGKKFKAHL 278
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
39-315 2.14e-118

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 343.51  E-value: 2.14e-118
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQ 118
Cdd:cd14974    1 IVSLVLYALIFLLGLPGNGLVIWVAGFKMKRTVNTVWFLNLALADFLFCLFLPFLIVYIAMGHHWPFGSVLCKLNSFVIS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCyNNFQKHDPDL 198
Cdd:cd14974   81 LNMFASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSC-NLTCVEDYDL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 TLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHnsYS 278
Cdd:cd14974  160 RRSRHKALTVIRFLCGFLLPLLIIAICYSVIAVKLRRKRLAKSSKPLRVLLAVVVAFFLCWLPYHVFALLELVAAA--GL 237
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 387763613 279 HHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd14974  238 PEVVLLGLPLATGLAYFNSCLNPILYVFMGQDFRKRL 274
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
40-315 6.79e-83

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 253.53  E-value: 6.79e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQL 119
Cdd:cd15116    2 LSMVIYSVVFVLGVLGNGLVIFITGFKMKKTVNTVWFLNLAVADFLFTFFLPFSIAYTAMDFHWPFGRFMCKLNSFLLFL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 120 NMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTV--EFNNHTLCYNNFQKHDPD 197
Cdd:cd15116   82 NMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTApsQNNNKIICFNNFSLSGDN 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 -------LTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWEL 270
Cdd:cd15116  162 sspevnqLRNMRHQVMTITRFLLGFLIPFTIIICCYAAIVLKLKRNRLAKSSKPFKIIAAVIVTFFLCWAPYHILNLLEM 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 387763613 271 tiHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15116  242 --EATRSPASVFKIGLPITSSLAFINSCLNPILYVFMGQDFKKFK 284
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
40-315 3.75e-71

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 223.46  E-value: 3.75e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQL 119
Cdd:cd15117    2 LSLVIYSSAFVLGTLGNGLVIWVTGFRMTRTVTTVCFLNLAVADFAFCLFLPFSVVYTALGFHWPFGWFLCKLYSTLVVF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 120 NMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQ-----KH 194
Cdd:cd15117   82 NLFASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVFRDTRKENGCTHCYLNFDpwnetAE 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 195 DPDLTLI----RHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWEL 270
Cdd:cd15117  162 DPVLWLEtvvqRLSAQVITRFVLGFLVPLVIIGGCYGLIAARLWREGWVHSSRPFRVLTAVVAAFFLCWFPFHLVSLLEL 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 387763613 271 TIHHNSYS--HHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15117  242 VVILNQKEdlNPLLILLLPLSSSLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
40-314 1.40e-62

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 200.77  E-value: 1.40e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQL 119
Cdd:cd15115    2 LSLVVLSLTFLLGVPGNGLVIWVAGLKMKRTVNTIWFLNLAVADLLCCLSLPFSIAHLLLNGHWPYGRFLCKLLPSIIVL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 120 NMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKhdpdlt 199
Cdd:cd15115   82 NMFASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRCGYDFLV------ 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 lirhhVLTWVKFIIGYLFPLLTMSICYLCLIFKVKK-RSILISSRHFWTILVVVVAFVVCWTPYHLFSIweLTIHHNSYS 278
Cdd:cd15115  156 -----AITITRAVFGFLLPLLIIAACYSFIAFRMQRgRFAKSQSKTFRVIIAVVVAFFVCWAPYHIIGI--LSLYGDPPL 228
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 387763613 279 HHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd15115  229 SKVLMSWDHLSIALAYANSCLNPVLYVFMGKDFKKK 264
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
39-315 5.09e-56

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 184.14  E-value: 5.09e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQ 118
Cdd:cd15114    1 VVALVLYAVVFLVGVPGNALVAWVTGFEAKRSVNAVWFLNLAVADLLCCLSLPILAVPIAQDGHWPFGAAACKLLPSLIL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVE--FNNHTLC---YNNFQK 193
Cdd:cd15114   81 LNMYASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSFIYRRIHQehFPEKTVCvvdYGGSTG 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 194 HDPDLTLIRhhvltwvkFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIH 273
Cdd:cd15114  161 VEWAVAIIR--------FLLGFLGPLVVIASCHGVLLVRTWSRRRQKSRRTLKVVTAVVVGFFLCWTPYHVVGLIIAASA 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 387763613 274 HNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15114  233 PNSRLLANALKADPLTVSLAYINSCLNPIIYVVAGRGFRKSL 274
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
43-315 1.95e-50

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 169.87  E-value: 1.95e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd14985    5 ALYIAIFLVGLLGNLFVVWvFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFLCKVSSYVISVNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDT--VEFNNHTLCYNNFqkhdPDLT 199
Cdd:cd14985   85 FASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLqaIENLNKTACIMLY----PHEA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 LirHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILI------SSRHFWTILVVVVAFVVCWTPYHLFS-----IW 268
Cdd:cd14985  161 W--HFGLSLELNILGFVLPLLIILTCYFHIARSLRKRYERTgkngrkRRKSLKIIFALVVAFLVCWLPFHFFKfldflAQ 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 387763613 269 ELTIHHNSYShHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd14985  239 LGAIRPCFWE-LFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
43-315 4.72e-49

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 166.45  E-value: 4.72e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15192    5 TVYSIIFVVGIFGNSLVVIVIYCYMKlKTVANIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASALVSFNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLI 201
Cdd:cd15192   85 YASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVFFIENTNITVCAFHYPSQNSTLL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 rhHVLTWVKFIIGYLFPLLTMSICYlCLIFKVKKRSILISSRH------FWTILVVVVAFVVCWTPYHLFSIWE----LT 271
Cdd:cd15192  165 --VGLGLMKNLLGFLIPFLIILTCY-TLIGKALKKAYEIQRNKprndeiFKMIMAVVLFFFFCWIPHQIFTFLDvliqLK 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 387763613 272 IHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15192  242 VIQDCHIADIVDTAMPFTICIAYFNSCLNPILYGFVGKNFRKKF 285
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
43-315 8.50e-49

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 165.55  E-value: 8.50e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFhWPFGIWLCKANSFTAQLNM 121
Cdd:cd14970    5 AVYSVVCVVGLTGNSLVIYvILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYLLGY-WPFGEVMCKIVLSVDAYNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTL-CYNNFqkhdPDLTL 200
Cdd:cd14970   84 FTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEGGTIsCNLQW----PDPPD 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVkKRSILISSRHFW-----------TILVVVVAFVVCWTPYHLFSIWE 269
Cdd:cd14970  160 YWGRVFTIYTFVLGFAVPLLVITVCYSLIIRRL-RSSRNLSTSGARekrrarrkvtrLVLVVVAVFVVCWLPFHVFQIVR 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 387763613 270 LTIhhnSYSHHVMQAGIPLSTG-LAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd14970  239 LLI---DPPETLTVVGVFLFCIaLSYANSCLNPILYAFLDENFRKSF 282
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
43-315 2.90e-48

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 164.18  E-value: 2.90e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15120    5 VALFVTFLVGLVVNGLYLWVLGFKMRRTVNTLWFLHLILSNLIFTLILPFMAVHVLMDNHWAFGTVLCKVLNSTLSVGMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDT-VEFNNHTLCYNNF------QKHD 195
Cdd:cd15120   85 TSVFLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLAFRETrLDEKGKTICQNNYalstnwESAE 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 196 PDLTLIRHHVLTWV-KFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTihh 274
Cdd:cd15120  165 VQASRQWIHVAMFVfRFLLGFLLPFLIITFCYVRMALKMKERGLARSSKPFKVMFTAVVSFFVCWLPYHLHSGLVLT--- 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 387763613 275 NSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15120  242 RGRPPSLTDITLLLTVGTTCFNTCFTPVLYLFVGENFKKVL 282
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
40-315 2.46e-47

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 161.66  E-value: 2.46e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQ 118
Cdd:cd14982    2 LFPIVYSLIFILGLLGNILALWvFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLFY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTV-EFNNHTLCYNNFQKHdpd 197
Cdd:cd14982   82 INMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIaKENNSTTCFEFLSEW--- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 ltLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRH-----FWTILVVVVAFVVCWTPYH----LFSIW 268
Cdd:cd14982  159 --LASAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSVrkrkaLRMILIVLAVFLVCFLPYHvtriLYLLV 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 387763613 269 ELTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd14982  237 RLSFIADCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
41-306 5.05e-47

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 161.12  E-value: 5.05e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  41 SLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15118    3 TICLHGIVSTLGIVENLLILWVVGFRLRRTVISIWILNLALSDLLATLSLPFFTYYLASGHTWELGTTFCRIHSSIFFLN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVE-FNNHTLCYNNFQKHDP--- 196
Cdd:cd15118   83 MFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVFRDVIErKDGRKLCYYNFALFSPspd 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 ---DLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIH 273
Cdd:cd15118  163 nnhPICKQRQEGLAISKLLLAFLIPLVIIAVSYAVVSLIIRHRCRRRPGRFVRLVVSVVVSFALCWAPYHIFSIIEVMAH 242
                        250       260       270
                 ....*....|....*....|....*....|...
gi 387763613 274 HNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVL 306
Cdd:cd15118  243 NQHSLRPLVIQGLPFATTLAFLNSVLNPVLYVF 275
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
43-317 1.79e-46

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 160.31  E-value: 1.79e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW--FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15190   15 VIYMLVFVLGLSGNGLVLWtvFRSKRKRRRSADTFIANLALADLTFVVTLPLWAVYTALGYHWPFGSFLCKLSSYLVFVN 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTV--EFNNHTLCYNNFQkhdpdL 198
Cdd:cd15190   95 MYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSdlEGTNKVICDMDYS-----G 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 TLIRHHVLTWV------KFIIGYLFPLLTMSICY------------LCLIFKVKKRSILISsrhfwTILVVVVAFVVCWT 260
Cdd:cd15190  170 VVSNESEWAWIaglglsSTVLGFLLPFLIMLTCYffigrtvarhfsKLRRKEDKKKRRLLK-----IIITLVVTFALCWL 244
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 387763613 261 PYHLFS----IWELTIHHNSYS-HHVMQAGIPLSTGLAFLNSCLNPILYVLiskkFQARFRS 317
Cdd:cd15190  245 PFHLVKtlyaLMYLGILPFSCGfDLFLMNAHPYATCLAYVNSCLNPFLYAF----FDPRFRQ 302
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
39-311 7.45e-46

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 157.76  E-value: 7.45e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAmnFHWPFGIWLCKANSFTA 117
Cdd:cd14984    1 VFLPVLYSLVFLLGLVGNSLVLLvLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAA--DGWVFGSFLCKLVSALY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 118 QLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFqkhDPD 197
Cdd:cd14984   79 TINFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSICSYDY---PED 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 LTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSI-----WELTI 272
Cdd:cd14984  156 TATTWKTLLRLLQNILGFLLPLLVMLFCYSRIIRTLLRARNHKKHRALRVIFAVVVVFFLCWLPYNIVLLldtlqLLGII 235
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 387763613 273 HHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKF 311
Cdd:cd14984  236 SRSCELSKSLDYALQVTESLAFSHCCLNPVLYAFVGVKF 274
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
55-304 2.61e-44

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 152.84  E-value: 2.61e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613   55 GNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVIS 132
Cdd:pfam00001   1 GNLLVILvILRNKKLRTPTNIFLLNLAVADLLFSLLtLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  133 LDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDT--VEFNNHTLCYNnfqkhDPDLTLIRHHVLTWVK 210
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTltVPEGNVTVCFI-----DFPEDLSKPVSYTLLI 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  211 FIIGYLFPLLTMSICYLCLIFKVKKRSILISS--------RHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYSHHVM 282
Cdd:pfam00001 156 SVLGFLLPLLVILVCYTLIIRTLRKSASKQKSsertqrrrKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSRLLD 235
                         250       260
                  ....*....|....*....|..
gi 387763613  283 QAgIPLSTGLAFLNSCLNPILY 304
Cdd:pfam00001 236 KA-LSVTLWLAYVNSCLNPIIY 256
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
42-308 2.31e-42

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 148.59  E-value: 2.31e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd00637    2 AVLYILIFVVGLVGNLLVILvILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPdltl 200
Cdd:cd00637   82 LLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTL---- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 irHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRH---------------FWTILVVVVAFVVCWTPYHLF 265
Cdd:cd00637  158 --SKAYTIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSsnssrrrrrrrerkvTKTLLIVVVVFLLCWLPYFIL 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 387763613 266 SIWELTIHHNSYSHHVMqagIPLSTGLAFLNSCLNPILYVLIS 308
Cdd:cd00637  236 LLLDVFGPDPSPLPRIL---YFLALLLAYLNSAINPIIYAFFN 275
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
40-305 2.79e-42

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 148.40  E-value: 2.79e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIWFTGFKWKK-TVTTLWFLNLAIADFIFLLFLPLYISYVAmNFHWPFGIWLCKANSFTAQ 118
Cdd:cd14975    2 LGCTLLSLAFAIGLPGNSFVIWSILIKVKQrSVTMLLVLNLALADLAVLLTLPVWIYFLA-TGTWDFGLAACKGCVYVCA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCynnFQKHDPDL 198
Cdd:cd14975   81 VSMYASVFLITLMSLERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVLLATPVIAFRHVEETVENGMC---KYRHYSDG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 TLIRHHVLtwvKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYS 278
Cdd:cd14975  158 QLVFHLLL---ETVVGFAVPFTAVVLCYSCLLRRLRRRRFRRRRRTGRLIASVVVAFAACWLPYHVGNLLEVVSELIGGS 234
                        250       260       270
                 ....*....|....*....|....*....|...
gi 387763613 279 H------HVMQAGIPLSTGLAFLNSCLNPILYV 305
Cdd:cd14975  235 KmagtlgKVAEAGRPIAGALAFLSSSINPLLYA 267
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
43-315 9.14e-42

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 147.26  E-value: 9.14e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWftGFKWKKTVTT-----LWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTA 117
Cdd:cd14976    5 VVYMVVFTVGLLGNLLVLY--LLKSNKKLRQqsesnKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYVT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 118 QLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGP-ALYFRDTVEFNNHTLCYNNFqkhdP 196
Cdd:cd14976   83 KLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPeAIFSTDTWSSVNHTLCLLRF----P 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 DLTLIRHHVlTWV------KFIIGYLFPLLTMSICYLCLIFKVKKRSILIS---SRHFWTILVVVVAFVVCWTPYHLFSI 267
Cdd:cd14976  159 KNSSVTRWY-NWLgmyqlqKVVLGFFLPLGIITLSYLLLLRFLQRKRGGSKrrkSRVTKSVFIVVLSFFICWLPNQALSL 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 387763613 268 WE-----LTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd14976  238 WSalikfDDVPFSDAFFAFQTYAFPVAICLAHSNSCLNPVLYCLVRREFRDAL 290
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
43-315 1.59e-41

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 146.73  E-value: 1.59e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKK-TVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15159    5 LFYSLILVFGLLGNTLALHVICQKRKKiNSTTLYLINLAVSDILFTLALPGRIAYYALGFDWPFGDWLCRLTALLFYINT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLC--YNNFQKhdpdlt 199
Cdd:cd15159   85 YAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPLLFMPMTKEMGGRITCmeYPNFEK------ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 LIRHHVLTWVKFIIGYLFPLLTMSICYL---CLIFKVKKRSIL-----ISSRHFWTILVVVVAFVVCWTPYHL----FSI 267
Cdd:cd15159  159 IKRLPLILLGACVIGFGVPVGIILFCYSqitLKLCRTAKENPLteksgHHKKACNVILLVLLVFVVCFSPYHLniiqFMI 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 387763613 268 WELTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15159  239 RKLLYQPSCSELKAFKISLQITVCLMNLNCCLDPFIYFFACKGYKKKV 286
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
43-315 3.40e-40

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 143.23  E-value: 3.40e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKK-TVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15168    5 IVYGVVFLVGLLLNSVVLYRFIFHLKPwNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDHWIFGDFMCKLVRFLFYFNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLI 201
Cdd:cd15168   85 YGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRTTCYDTTSPEELNDYVI 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTwvkfIIGYLFPLLTMSICYLCLIFKVKKR-----SILISSRHFWTILVVVVAFVVCWTPYHL-----FSIWELT 271
Cdd:cd15168  165 YSMVLT----GLGFLLPLLIILACYGLIVRALIRKlgegvTSALRRKSIRLVIIVLALFAVCFLPFHVtrtinLAARLLS 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 387763613 272 IHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15168  241 GTASCATLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
40-315 1.64e-39

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 141.40  E-value: 1.64e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVI--WFTGFKWKKTVTT-LWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFT 116
Cdd:cd15098    2 IVPVVFGLIFCLGVLGNSLVItvLARVKPGKRRSTTnVFILNLSIADLFFLLFCVPFQATIYSLPEWVFGAFMCKFVHYF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 117 AQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVE---FNNHTLCYNNFqk 193
Cdd:cd15098   82 FTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDLVHhwtASNQTFCWENW-- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 194 HDPDltliRHHVLTWVKFIIGYLFPLLTMSICYLCLIF----KVK---KRSILISSRHFWTILVVVVAFVVCWTPYHLFS 266
Cdd:cd15098  160 PEKQ----QKPVYVVCTFVFGYLLPLLLITFCYAKVLNhlhkKLKnmsKKSERSKKKTAQTVLVVVVVFGISWLPHHIIH 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 387763613 267 IW----ELTIHHNSYSHHVmqagipLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15098  236 LWvefgDFPLTQASFVLRI------TAHCLAYANSCVNPIIYAFLSENFRKAY 282
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
43-315 5.64e-39

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 139.89  E-value: 5.64e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15191    5 VLYSIIFILGFLGNSLVVCvFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGSLLTLNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRhRTLKNSLIVIIFIWLLASLIGGPALYFRDT--VEFNNHTLCYNNFQKHDpdlT 199
Cdd:cd15191   85 FASIFFITCMSVDRYLAVVYPLRSQR-RRSWQARLVCLLVWVLACLSSLPTFYFRDTyyIEELGVNACIMAFPNEK---Y 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 LIRHHVLTWVKFIIGYLFPLLTMSICYLCL-IFKVKKRSILISSRH----FWTILVVVVAFVVCWTPYHLFSIWELTIHH 274
Cdd:cd15191  161 AQWSAGLALMKNTLGFLIPLIVIATCYFGIgRHLLKTKGFGKNKQRrdkvLKMVAAVVLAFLICWFPFHVLTFLDALARM 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 387763613 275 NSYSHHVMQAGI----PLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15191  241 GVINNCWVITVIdkalPFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
43-315 1.82e-37

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 135.86  E-value: 1.82e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGF-KWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMnfHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15178    5 VIYVLVFLLSLPGNSLVVLVILYnRRSRSSTDVYLLHLAIADLLFALTLPFWAVSVVK--GWIFGTFMCKLVSLLQEANF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKnSLIVIIFIWLLASLIGGPALYFRD--TVEFNNHTLCYNNFQKHDPD-- 197
Cdd:cd15178   83 YSGILLLACISVDRYLAIVHATRALTQKRHL-VKFVCAGVWLLSLLLSLPALLNRDafKPPNSGRTVCYENLGNESADkw 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 ---LTLIRHhvltwvkfIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHH 274
Cdd:cd15178  162 rvvLRILRH--------TLGFLLPLVVMLFCYGFTIKTLLQTRSFQKHRAMRVIFAVVLAFLLCWLPYNVTVLIDTLMRT 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 387763613 275 NSYS------HHVMQAgIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15178  234 KLITetcelrNHVDVA-LYVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
43-312 7.81e-37

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 134.25  E-value: 7.81e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFK--WKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15926    5 IVYSVVCALGLVGNLLVLYLMKSKqgWKKSSINLFVTSLAVTDFQFVLTLPFWAVENALDFTWLFGKAMCKIVSYVTAMN 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNF--QKHDPDL 198
Cdd:cd15926   85 MYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSNEELCLVKFpdNRGNAQF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 TLIRHHVLtwvKFIIGYLFPLLTMSICYLCLIFKVKKRSILIS-----SRHFWTILVVVVAFVVCWTPYHLFSIW----E 269
Cdd:cd15926  165 WLGLYHAQ---KVLLGFLIPLGIISLCYLLLVRFITDKNITGSstkrrSKVTKSVTIVVLSFFLCWLPNQALTTWgiliK 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 387763613 270 LTIHHNSYSHHVMQAGI-PLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15926  242 LNVVHFSYEYFTTQVYIfPITVCLAHSNSCLNPILYCLMRREFR 285
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
43-304 2.29e-36

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 133.06  E-value: 2.29e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15194    5 ILYCLVFLVGAVGNAILMGALVFKRGvRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYIISVNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCynnfqkHDPDLTLI 201
Cdd:cd15194   85 YCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYC------NEDAGTPS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RhHVLTWVKFIIGYLFPLLTMSICYLCLIFKV-------------KKRSILIssrhfwtILVVVVAFVVCWTPYHLFS-- 266
Cdd:cd15194  159 K-VIFSLVSLIVAFFLPLLSILTCYCTIIWKLchhyqksgkhqkkLRKSIKI-------VFIVVAAFVFSWMPFNLFKal 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 387763613 267 --IWELTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILY 304
Cdd:cd15194  231 aiASGLQVEVTCLPYTLAQLGMEVSAPLAFANSCANPFIY 270
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
43-315 5.79e-36

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 131.75  E-value: 5.79e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15161    5 LFYILVFILAFPGNTLALWlFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEVPCRLAGFLFYLNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPdltli 201
Cdd:cd15161   85 YASLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLLVSPQTVEVNNTTVCLQLYREKAS----- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 rHHVLtwVKFIIGYLFPLLTMSICYLCLIFKVKKRSIL---ISSRHFWTILVVVVAFVVCWTPYHLFSIweltIHHNSYS 278
Cdd:cd15161  160 -RGAL--VSLAVAFTIPFVTTVTCYLLIIRSLRTGKREekpLKDKAIKMIILVLTIFLICFVPYHISRY----IYILSHN 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 387763613 279 HH----VMQAGIPLS----TGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15161  233 GAgascSSRRGLALAnritSCLTCLNGALDPVMYFFVAEKFRETL 277
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
39-315 1.43e-35

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 130.66  E-value: 1.43e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTA 117
Cdd:cd14971    1 WIVPLFFALIFLLGLVGNSLVILvVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 118 QLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPD 197
Cdd:cd14971   81 QVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGNRTVCSEAWPSRA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 LTLIrhhvLTWVKFIIGYLFPLLTMSICYLCLI---------FKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIW 268
Cdd:cd14971  161 HRRA----FALCTFLFGYLLPLLLICVCYAAMLrhlwrvavrPVLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILLL 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 387763613 269 -ELTIHHNSYSHHVMQAgipLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd14971  237 vALGPFPLTYATYALRI---WAHCLAYSNSAVNPVLYAFLSEHFRKAF 281
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
39-315 9.84e-35

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 128.87  E-value: 9.84e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLF-LPL-YISYVAMNfhWPFGIWLCKANSF 115
Cdd:cd14993    1 IVLIVLYVVVFLLALVGNSLVIAvVLRNKHMRTVTNYFLVNLAVADLLVSLFcMPLtLLENVYRP--WVFGEVLCKAVPY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 116 TAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNN-------HTLCy 188
Cdd:cd14993   79 LQGVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISsepgtitIYIC- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 189 nnFQKHDPDltlIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSIL----ISSRHFWTILVVV------------ 252
Cdd:cd14993  158 --TEDWPSP---ELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPgdrgSANSTSSRRILRSkkkvarmlivvv 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 387763613 253 VAFVVCWTPYHLFSIW-ELTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd14993  233 VLFALSWLPYYVLSILlDFGPLSSEESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRGF 296
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
40-305 2.73e-34

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 127.24  E-value: 2.73e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIWFTGFKWKK-TVTTLWFLNLAIADFIFLLFLPLYISYVAmNFHWPFGIWLCKANSFTAQ 118
Cdd:cd15121    2 LGIAILSLAFILGFPGNLFVVWSVLCRMKKrSVTCILVLNLALADAAVLLTAPFFLHFLS-GGGWEFGSVVCKLCHYVCG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFN-NHTLCynnFQKHDPD 197
Cdd:cd15121   81 VSMYASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPMPFYRTVLKKNiNMKLC---IPYHPSV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 LTLIRHHVLtwvKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELT--IHHN 275
Cdd:cd15121  158 GHEAFQYLF---ETITGFLLPFTAIVTCYSTIGRRLRSARFRRKRRTNRLVVLIIATFALFWLPYHVVNLIQVAgaLQNQ 234
                        250       260       270
                 ....*....|....*....|....*....|...
gi 387763613 276 SYSHHVMQAGI---PLSTGLAFLNSCLNPILYV 305
Cdd:cd15121  235 AGNASVLKAAKlarPNVTALAFLSSSVNPVLYA 267
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
40-315 9.43e-34

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 126.05  E-value: 9.43e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfHWPFGIWLCKANSFTAQ 118
Cdd:cd15094    2 ISAVLYGLICIVGLVGNGLVIYvVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMILK-YWPFGAAMCKIYMVLTS 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPdl 198
Cdd:cd15094   81 INQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIVWPDSSA-- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 tLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVK------KRSILISSRHFWT--ILVVVVAFVVCWTPYHLFSIWEL 270
Cdd:cd15094  159 -VNGQKAFTLYTFLLGFAIPLLLISVFYTLVILRLRtvgpknKSKEKRRSHRKVTrlVLTVISVYIICWLPYWAFQVHLI 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 387763613 271 TIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15094  238 FLPPGTDMPKWEILMFLLLTVLSYANSMVNPLLYAFLSENFRKSF 282
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
43-314 4.28e-33

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 124.09  E-value: 4.28e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15193    5 ILYLIIFFTGLLGNLFVIALMSKRSTtKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFIIAVNR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDtveFNNHTLCYNnfqkhDPDLTLI 201
Cdd:cd15193   85 CSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRN---LINESVCVE-----DSSSRFF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWVkfIIGYLFPLLTMSICYLCL-------------IFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIW 268
Cdd:cd15193  157 QGISLATL--FLTFVLPLIVILFCYCSIlvrlrrhfhgakrTGRRRRNSLRIVFAIVTAFVLSWLPFNTLKAVRLLLELG 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 387763613 269 ELTIhhNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd15193  235 GGVL--PCHTTVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFRRR 278
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
44-315 1.70e-32

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 122.57  E-value: 1.70e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIWFT-GFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15093    6 IYAVVCLVGLCGNSLVIYVVlRYAKMKTVTNIYILNLAIADELFMLGLPFLAASNALR-HWPFGSVLCRLVLSVDGINMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNnfqKHDPDLTLIR 202
Cdd:cd15093   85 TSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTRENQDGSSACN---MQWPEPAAAW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 203 HHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISS--------RHFWTILVVVVAFVVCWTPYHLFSIWELTIHH 274
Cdd:cd15093  162 SAGFIIYTFVLGFLLPLLIICLCYLLIVIKVKSAGLRAGWqqrkrserKVTRMVVMVVVVFVICWLPFYVLQLVNVFVQL 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 387763613 275 NSYShhVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15093  242 PETP--ALVGVYHFVVILSYANSCANPILYGFLSDNFKKSF 280
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
43-315 3.61e-32

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 121.74  E-value: 3.61e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGN--AIVIWFTGFKwKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15157    5 TVYLIIFVLGVVGNglSIYVFLQPSK-KKTSVNIFMLNLAVSDLMFVSTLPFRADYYLMGSHWVFGDIACRIMSYSLYVN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPaLYFRDTVEFNNHTLCynnFQKHDPDLTL 200
Cdd:cd15157   84 MYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAASSP-LLSKGTSKYNSQTKC---LDLHPSKIDK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRhhVLTWVKFIIGYLFPLLTMSICYLCLI-----FKVKKRSILISSRH-FWTILVVVVAFVVCWTPYHLFSIWELTIHH 274
Cdd:cd15157  160 LL--ILNYIVLVVGFILPFCTLSICYILIIkallkPRVPQSKLRVSHKKaLLTIIITLILFLLCFLPYHILRTVHLMQWS 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 387763613 275 NSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15157  238 EGQCNLRLHKAVVITLCLAAANSCLDPLLYYFAGENFKERL 278
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
44-315 5.07e-32

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 121.12  E-value: 5.07e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15973    6 IYALVCLVGLIGNSMVIFvILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQ-HWPFGSAMCRTVLSVDGINMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYnNFQKHDPDLTLir 202
Cdd:cd15973   85 TSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGQAVAC-NLIWPHPAWSA-- 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 203 hhVLTWVKFIIGYLFPLLTMSICYLCLIFKV-----------KKRSILISSRhfwTILVVVVAFVVCWTPYHLFSIWELT 271
Cdd:cd15973  162 --AFVIYTFLLGFLLPVLAIGLCYILIIGKMravalkagwqqRRKSEKKITR---MVLMVVTVFVICWMPFYVVQLLNLF 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 387763613 272 IHHnsyshhvMQAGIP-LSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15973  237 LPR-------LDATVNhASLILSYANSCANPILYGFLSDNFRRSF 274
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
43-314 1.20e-31

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 120.25  E-value: 1.20e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKKTVTT-LWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15088    5 SVFGCICVVGLVGNGIVLYVLVRCSKLRTAPdIFIFNLAVADLLFMLGMPFLIHQFAIDGQWYFGEVMCKIITALDANNQ 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHT-LCYNNFQKHDPDLTL 200
Cdd:cd15088   85 FTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTtFCYVSLPSPDDLYWF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRHHvltwvkFIIGYLFPLLTMSICYLCLIFK-----VKKRSILISSRHF---WTILVVVVAFVVCWTPYHLFSIWELTI 272
Cdd:cd15088  165 TIYH------FILGFAVPLVVITVCYILILHRlargvAPGNQSHGSSRTKrvtKMVILIVVVFIVCWLPFHVVQLVNLAM 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 387763613 273 HHNSYSHHVmqaGIPLSTGLAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd15088  239 NRPTLAFEV---AYFLSICLGYANSCLNPFVYILVSENFRKR 277
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
43-315 2.65e-31

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 119.68  E-value: 2.65e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIwFTGFKWK--KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15927    5 ILFALIFLVGVLGNGTLI-LIFLRNKsmRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLKDTS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEF-----NNHTLCYNNFQKHD 195
Cdd:cd15927   84 IGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFtltdnQTIQICYPYPQELG 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 196 PDLTLIRhhvlTWVKFIIGYLFPLLTMSICYlCLIfkvkKRSILISSRHFW-------------------TILVVVVAFV 256
Cdd:cd15927  164 PNYPKIM----VLLRFLVYYLIPLLIIGVFY-VLM----ARHLIRSTRNIGsgqnqaaqrqiearkkvakTVLAFVVLFA 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 387763613 257 VCWTPYHLFSIWeLTIHHNSYS-----HHVMQAgipLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15927  235 VCWLPRHVFMLW-FHFAPNGLVdynafWHVLKI---VGFCLSFINSCVNPVALYLLSGSFRRHF 294
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
47-315 4.00e-31

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 119.14  E-value: 4.00e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  47 LAFVLGIPGNAIVIWFTGFKWK---KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfHWPFGIWLCKANSFTAQLNMFA 123
Cdd:cd15122    9 LAALLGLPGNGFIIWSILWKMKargRSVTCILILNLAVADGAVLLLTPFFITFLTRK-TWPFGQAVCKAVYYLCCLSMYA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 124 SVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFN--NHTLCYNNfqkHDPDLTLI 201
Cdd:cd15122   88 SIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVYRHVWKDEgmNDRICEPC---HASRGHAI 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVL-TWVKFIIgylfPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYS-- 278
Cdd:cd15122  165 FHYTFeTLVAFVL----PFGVILFSYSVILVRLKGARFRRRARVEKLIAAIVVAFALLWVPYHVVNLLQVVANLAPGEvl 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 387763613 279 ---HHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15122  241 eklGGAAKAARAGATALAFFSSSVNPLLYVFAAGDLIKTS 280
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
42-315 4.70e-31

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 118.82  E-value: 4.70e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFhWPFGIWLCKANSFTAQLN 120
Cdd:cd15092    4 VVVYLIVCVVGLVGNCLVMYvILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDIFLGF-WPFGNALCKTVIAIDYYN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFqkhdPDLTL 200
Cdd:cd15092   83 MFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIECLVEI----PTPQD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRH--------FWTILVVVVAFVVCWTPYHLFSIWELTI 272
Cdd:cd15092  159 YWDPVFGICVFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSKEkdrnlrriTRLVLVVVAVFVGCWTPIQIFVLAQGLG 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 387763613 273 HHNSYSHHVmqAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15092  239 VQPSSETAV--AILRFCTALGYVNSSLNPVLYAFLDENFKACF 279
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
43-315 5.53e-31

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 118.39  E-value: 5.53e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIV--IWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15097    5 VVFSLIFLLGTVGNSLVlaVLLRSGQSGHNTTNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIYLT 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYnnfqkhdPDLTL 200
Cdd:cd15097   85 MYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSYYDLIDYANSTVCM-------PGWEE 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRHHVLTWVKFIIGYLFPLLTMSICYlclifkvkKRSIlissRHFWT---------------------ILVVVVAFVVCW 259
Cdd:cd15097  158 ARRKAMDTCTFAFGYLIPVLVVSLSY--------TRTI----KYLWTavdpleamseskrakrkvtkmIIIVTALFCLCW 225
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 260 TPYH--LFSIW--ELTIHHNSYSHHVmqagipLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15097  226 LPHHvvILCYLygDFPFNQATYAFRL------LSHCMAYANSCLNPIVYALVSKHFRKGF 279
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
50-314 6.68e-31

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 118.36  E-value: 6.68e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  50 VLGIPGNAIVIWFTGFKWKK-TVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFL 128
Cdd:cd15380   12 FFGLLGNLFVLFVFLLPRRRlTIAEIYLANLAASDLVFVLGLPFWAENIRNQFNWPFGNFLCRVISGVIKANLFISIFLV 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 129 TVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLIRHHVLTw 208
Cdd:cd15380   92 VAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHVPDLNISACILLFPHEAWHFARRVELN- 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 209 vkfIIGYLFPLLTMSICYLCLIFKVKKRSI--------LISSRHFWTILVVVVAFVVCWTPYHLFSIWE----LTIHHNS 276
Cdd:cd15380  171 ---IVGFLLPLAAIVFFNFHIIASLRERTEesrkrcggLKDTKATRLILTLVLMFLVCWTPYHFFAFLDflfqVEVIQGC 247
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 387763613 277 YSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd15380  248 FWEEFIDLGLQLANFFAFANSCLNPVIYVFAGKLFRTK 285
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
44-315 6.92e-31

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 118.09  E-value: 6.92e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15970    6 IYSVVCLVGLCGNSMVIYvILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLR-HWPFGSLLCRLVLSVDAINMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYnNFQKHDPDLTLIR 202
Cdd:cd15970   85 TSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAPNSDGSVAC-NMQMPEPSQRWLA 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 203 HHVLtwVKFIIGYLFPLLTMSICYLCLIFKV-----------KKRSiliSSRHFWTILVVVVAFVVCWTPYHLFSIWELT 271
Cdd:cd15970  164 VFVV--YTFLMGFLLPVIAICLCYILIIVKMrvvalkagwqqRKRS---ERKITLMVMMVVTVFVICWMPFYVVQLVSVF 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 387763613 272 IHHNSYShhVMQagipLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15970  239 VGQHDAT--VSQ----LSVILGYANSCANPILYGFLSDNFKRSF 276
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
40-315 8.58e-31

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 117.28  E-value: 8.58e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIwFTGFKWKK--TVTTLWFLNLAIADFIFLLF-LPLYISYVAMNfHWPFGIWLCKANSFT 116
Cdd:cd14967    1 LLAVFLSLIILVTVFGNLLVI-LAVYRNRRlrTVTNYFIVSLAVADLLVALLvMPFSAVYTLLG-YWPFGPVLCRFWIAL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 117 AQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYnnfqkhdp 196
Cdd:cd14967   79 DVLCCTASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCE-------- 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 dLTLIRHHVLTWVKFIIGYLFPLLTMSICYlCLIFKVKKRSIlissRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHns 276
Cdd:cd14967  151 -CEFTPNKIYVLVSSVISFFIPLLIMIVLY-ARIFRVARREL----KAAKTLAIIVGAFLLCWLPFFIIYLVSAFCPP-- 222
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 387763613 277 ysHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd14967  223 --DCVPPILYAVFFWLGYLNSALNPIIYALFNRDFRRAF 259
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
47-314 1.33e-30

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 117.56  E-value: 1.33e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  47 LAFVLGIPGNAIV-IWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASV 125
Cdd:cd15381    9 IIFVLGTIENAFVlIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGFNWPFGEFLCKSVNAVIYMNLYSSI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 126 FFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLIRHHV 205
Cdd:cd15381   89 YFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEYNITACVLDYPSEGWHVALNIL 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 206 LTwvkfIIGYLFPLLTMSICYLCLIFKV------KKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYS- 278
Cdd:cd15381  169 LN----VVGFLIPLSIITFCSTQIIQVLrnnkmqKFKEIQTERKATVLVLAVLLMFFICWLPFHIFTFLDTLHKLGLISg 244
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 387763613 279 ---HHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd15381  245 crwEDILDIGTQIATFLAYSNSCLNPLLYVIVGKHFRKK 283
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
43-312 1.87e-30

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 117.16  E-value: 1.87e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYIsyVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15174    5 PLYWLIFLVGAVGNSLVVLiYTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWA--TAASSGWVFGTFLCKVVNSMYKINF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSH--RHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLT 199
Cdd:cd15174   83 YSCMLLLTCISVDRYIAIVQATKAHnsKNKRLLYSKLVCFFVWLLSTILSLPEILFSQSKEEESVTTCTMVYPSNESNRF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 LIRHHVLtwvKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNS--Y 277
Cdd:cd15174  163 KVAVLAL---KVTVGFFLPFVVMVICYTLIIHTLLQAKRFQKHKALKVIIAVVTVFVLSQLPYNSILLIKTINAYNItiT 239
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 387763613 278 SHHVMQA---GIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15174  240 DCATSQNldiAGQVTQSIAFLHSCLNPFLYVFVGVRFR 277
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
42-315 2.59e-30

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 116.94  E-value: 2.59e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYIsYVAMNFHWPFGIWLCKANSFTAQL 119
Cdd:cd15203    4 ILLYGLIIVLGVVGNLLVIYvVLRNKSMQTVTNIFILNLAVSDLLLCLVsLPFTL-IYTLTKNWPFGSILCKLVPSLQGV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 120 NMFASVFFLTVISLDHYIHLIHPV---LSHRHrtlknSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDP 196
Cdd:cd15203   83 SIFVSTLTLTAIAIDRYQLIVYPTrprMSKRH-----ALLIIALIWILSLLLSLPLAIFQELSDVPIEILPYCGYFCTES 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 DLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSI-------LISSRHFWTI----------LVVVVAFVVCW 259
Cdd:cd15203  158 WPSSSSRLIYTISVLVLQFVIPLLIISFCYFRISLKLRKRVKkkrgkrtLSSRRRRSELrrkrrtnrllIAMVVVFAVCW 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 387763613 260 TPYHLFSI---WELTIHHNSYSHHVMQAgipLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15203  238 LPLNLFNLlrdFEPLPQIDGRHFYLIFL---ICHLIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
43-315 2.90e-30

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 116.83  E-value: 2.90e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15921    5 TAYILIFILGLTGNSISVYVFLSQYRsQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNSHWPFGDIACRIILYVLYVNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLI 201
Cdd:cd15921   85 YSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKSKQHDEGSTRCLELAHDAVDKLLLI 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHhvltwVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISS------RHFWTILVVVVAFVVCWTPYHLFSIWELTIHHN 275
Cdd:cd15921  165 NY-----VTLPVGFVVPFMTVIFCYIFIIKNLLKPSPALGRtrpsrrKACALIIISLGIFLVCFLPYHIVRTIHLITERQ 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 387763613 276 SY----SHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15921  240 IKescgYILRVRKAAVITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
44-312 4.67e-30

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 116.12  E-value: 4.67e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVaMNFHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15183    6 LYSLVFIIGVVGNVLVVLvLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFWIDYK-LKDDWIFGDAMCKFLSGFYYLGLY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALY-FRDTVEFNNHTLcynnfQKHDPDLTLI 201
Cdd:cd15183   85 SEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYfFKSQWEFTHHTC-----SAHFPRKSLI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWVKF-IIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHL---FSIWE--LTIHHN 275
Cdd:cd15183  160 RWKRFQALKLnLLGLILPLLVMIICYTGIINILLRRPNEKKAKAVRLIFVITLLFFLLWTPYNLaafVSAFQdvLFTPSC 239
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 387763613 276 SYSHHVMQAgIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15183  240 EQSQQLDLA-LQVTEVIAYTHCCVNPVIYVFVGERFR 275
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
44-315 6.91e-30

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 115.71  E-value: 6.91e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMnFHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15971    6 IYFVVCIIGLCGNTLVIYvILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQVAL-VHWPFGKAICRVVMTVDGINQF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFqkhdPDLTLIR 202
Cdd:cd15971   85 TSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRSSCTIIW----PGESSAW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 203 HHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISS--------RHFWTILVVVVAFVVCWTPYHLFSIWELTIHH 274
Cdd:cd15971  161 YTGFIIYTFILGFFVPLTIICLCYLFIIIKVKSSGIRVGSskrkksekKVTRMVSIVVAVFVFCWLPFYIFNVSSVSVSI 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 387763613 275 NSYShhVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15971  241 SPTP--GLKGMFDFVVVLSYANSCANPILYAFLSDNFKKSF 279
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
44-315 7.27e-30

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 115.43  E-value: 7.27e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15089    6 LYSVVCVVGLLGNVLVMYgIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLME-TWPFGELLCKAVLSIDYYNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHT-LCYNNFqkhdPDLTLI 201
Cdd:cd15089   85 TSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPRDGAvVCMLQF----PSPSWY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRH--------FWTILVVVVAFVVCWTPYHLFSIWELTIH 273
Cdd:cd15089  161 WDTVTKICVFIFAFVVPILVITVCYGLMILRLRSVRLLSGSKEkdrnlrriTRMVLVVVAAFIICWTPIHIFVIVWTLVD 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 387763613 274 HNSYSHHVMqAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15089  241 IDRRNPLVV-AALHLCIALGYANSSLNPVLYAFLDENFKRCF 281
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
42-315 1.08e-29

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 114.68  E-value: 1.08e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15001    3 IIVYVITFVLGLIGNSLVIFvVARFRRMRSVTNVFLASLATADLLLLVFCVPLKTAEYFSPTWSLGAFLCKAVAYLQLLS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHT-LCYNNFQKHDPDLT 199
Cdd:cd15001   83 FICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASPVLFGQGLVRYESENgVTVYHCQKAWPSTL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 LIRHHVLTwvKFIIGYLFPLLTMSICYLClifKVKKRSILissrhfwTILVVVVAFVVCWTP---YHLFSIWELTIHHNS 276
Cdd:cd15001  163 YSRLYVVY--LAIVIFFIPLIVMTFAYAR---DTRKQVIK-------MLISVVVLFAVCWGPlliDNLLVSFDVISTLHT 230
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 387763613 277 YSHHVMQAGIPLstgLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15001  231 QALKYMRIAFHL---LSYANSCINPIIYAFMSKNFRSSF 266
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
44-315 1.43e-29

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 114.79  E-value: 1.43e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIWFTGFKWKK-TVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15967    6 VYILVFVVGLVGNVWGLKSLLANWKKlGNINVFVLNLGLADLLYLLTLPFLVVYYLKGRKWIFGQVFCKITRFCFNLNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVefNNHTLCYNN-FQKHDPDLTLi 201
Cdd:cd15967   86 GSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDLFFSKTN--SNGTKCFDTtFNDYLESYLT- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 rhHVLTWVkfIIGYLFPLLTMSICY------LCLIFKVKKrsiLISSRHFWTILVVVVAFVVCWTPYHLFS-------IW 268
Cdd:cd15967  163 --YSLGWT--VTGFVIPLLIILGCYghvvvvLCRNNNVDK---GLKQRCLKLVIILIVLFSVCYIPYHVFRnlnllsrIL 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 387763613 269 ELTIHHNSYSHHVMQAGiPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15967  236 QKQGSCTQWFRGIYIAH-QVSRGLVCLNSALNPLVYLMGSEDILSRI 281
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
39-315 1.60e-29

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 114.70  E-value: 1.60e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTA 117
Cdd:cd15096    1 IVVPVIFGLIFIVGLIGNSLVILVVLSNQQmRSTTNILILNLAVADLLFVVFCVPFTATDYVLPTWPFGDVWCKIVQYLV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 118 QLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPD 197
Cdd:cd15096   81 YVTAYASVYTLVLMSLDRYLAVVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGVVSYGFSSEAYSYCTFLTEV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 LTLIRHHVLTWvkFIIGYLFPLLTMSICYLCLIFKVKKR----------SILISSRHFWTILVVVVAFVVCWTPYHL-FS 266
Cdd:cd15096  161 GTAAQTFFTSF--FLFSYLIPLTLICVLYMLMLRRLRRQkspggrrsaeSQRGKRRVTRLVVVVVVVFAICWLPIHIiLL 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 387763613 267 IWELTIHHNSYSHHVMQagiPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15096  239 LKYYGVLPETVLYVVIQ---ILSNCLAYGNSCVNPILYAFLSQNFRKAF 284
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
43-312 2.80e-29

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 113.73  E-value: 2.80e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAI--VIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAmnFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15188    5 VFYTLVFLLGLAGNLLlfVVLLLYVPKKKKMTEVYLLNLAVSDLLFLVTLPFWAMYVA--WHWVFGSFLCKFVSTLYTIN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHT-LCYNNFQKHDpdlt 199
Cdd:cd15188   83 FYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQTHHTNNGVwVCHADYGGHH---- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 LIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYH----LFSIWELTIHHN 275
Cdd:cd15188  159 TIWKLVFQFQQNLLGFLFPLLAMVFFYSRIACVLTRLRPPGQGRALRFVAALVVVFFVLWFPYNltlfLHSLQDLHVIGN 238
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 387763613 276 SYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15188  239 CERSRHLDYALQVTESLAFVHCCLNPLLYAFVSKRFR 275
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
43-313 3.05e-29

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 114.02  E-value: 3.05e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKK-TVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15160    5 VVYSFVFVVGLPANCLALWVLYLQIKKeNVLGVYLLNLSLSDLLYILTLPLWIDYTANHHNWTFGPLSCKVVGFFFYTNI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEF-NNHTLCYNNFQKHDpdltl 200
Cdd:cd15160   85 YASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFLGHDELFRDePNHTLCYEKYPMEG----- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 iRHHVLTWVKFIIGYLFPLLTMSICYlCLIFKVKKRSILISS------RHFwtILVVVVAFVVCWTPYHLFSIWELTIHH 274
Cdd:cd15160  160 -WQASYNYARFLVGFLIPLSLILFFY-RRVLRAVRQSPSLEReekrkiIGL--LLSIVVIFLLCFLPYHVVLLVRSVIEL 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 387763613 275 NSYSHHVMQAGI----PLSTGLAFLNSCLNPILYVLISKKFQA 313
Cdd:cd15160  236 VQNGLCGFEKRVftayQISLCLTSLNCVADPILYIFVTEDVRQ 278
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
43-312 3.07e-29

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 113.71  E-value: 3.07e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTG-FKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfhWPFGIWLCKANSFTAQLNM 121
Cdd:cd15179    5 TVYSIIFLLGIVGNGLVILVMGyQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAAAN--WYFGNFLCKAVHVIYTVNL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLI 201
Cdd:cd15179   83 YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRYICDRIYPEDTFELWVV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 rhhVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHL------FSIWELtIHHN 275
Cdd:cd15179  163 ---AFRFQHILVGLVLPGLVILTCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIgisidtFMLLEI-IKQS 238
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 387763613 276 SYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15179  239 CEMEQTVHKWISITEALAFFHCCLNPILYAFLGAKFK 275
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
39-312 3.82e-29

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 113.30  E-value: 3.82e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQ 118
Cdd:cd15372    1 RLVPSLYTLVFLVGLPANGLALWVLATQVKRLPSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFFY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDT--VEFNNHTLCYNNFQKHDP 196
Cdd:cd15372   81 GNMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSypLERLNITLCHDVLPLDEQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 DLTLIRHHvltWVKFIIGYLFPLLTMSICYLCLIfkvkkRSILISSRHF----WTILVVVVAFVVCWTPYHLFsiweLTI 272
Cdd:cd15372  161 DTYLFYYF---ACLAVLGFLLPLVVILFCYGSVL-----HTLLRSGQRYghamKLTVLVLVSFVLCFTPSNLL----LLL 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 387763613 273 HHNSYS---HHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15372  229 HYSDPTlddGGNLYIVYMVSLAISTLNSCVDPFIYYYVSEEFR 271
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
39-315 5.82e-29

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 113.15  E-value: 5.82e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIWFTG-FKWKKTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNfHWPFGIWLCKANSFT 116
Cdd:cd15095    1 WLVPLIFAIIFLVGLAGNSLVIYVVSrHREMRTVTNYYIVNLAVTDLAFLVCcVPFTAALYATP-SWVFGDFMCKFVNYM 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 117 AQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVE---FNNHTLCYNNFqk 193
Cdd:cd15095   80 MQVTVQATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEgywYGPQTYCREVW-- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 194 hdPDLTLIRHHVLTWVkfIIGYLFPLLTMSICYLCLIFKVKKRSIL------ISSRHFWT--------ILVVVVAFVVCW 259
Cdd:cd15095  158 --PSKAFQKAYMIYTV--LLTYVIPLAIIAVCYGLILRRLWRRSVDgnnqseQLSERALRqkrkvtrmVIVVVVLFAICW 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 387763613 260 TPYHLFSIWELTIHHNSYSHHVMQAGIpLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15095  234 LPNHVLNLWQRFDPNFPETYATYALKI-AALCLSYANSAVNPFVYAFMGENFRKYF 288
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
43-315 1.15e-28

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 112.39  E-value: 1.15e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWF-TGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15390    5 IVFVVMVLVAIGGNLIVIWIvLAHKRMRTVTNYFLVNLAVADLLISAFNTVFNFTYLLYNDWPFGLFYCKFSNFVAITTV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVlshRHRTLKNS-LIVIIFIWLLASLIGGPALYFRDTVEFN-----NHTLCYNNFQKHD 195
Cdd:cd15390   85 AASVFTLMAISIDRYIAIVHPL---RPRLSRRTtKIAIAVIWLASFLLALPQLLYSTTETYYyytgsERTVCFIAWPDGP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 196 PDLTLIRHHVltwVKFIIGYLFPLLTMSICYLCLIFKVKKRSIL--ISSRHFWTI----------LVVVVAFVVCWTPYH 263
Cdd:cd15390  162 NSLQDFVYNI---VLFVVTYFLPLIIMAVAYTRVGVELWGSKTIgeNTPRQLESVrakrkvvkmmIVVVVIFAICWLPYH 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 387763613 264 LFSIWeLTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15390  239 LYFIL-TYLYPDINSWKYIQQIYLAIYWLAMSNSMYNPIIYCWMNKRFRYGF 289
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
44-315 1.50e-28

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 111.97  E-value: 1.50e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15091    6 VYSVVFVVGLVGNSLVMFvIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMN-SWPFGDVLCKIVISIDYYNMF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYF--RDTVEFNNHTLCYNNFQKHDPDLTL 200
Cdd:cd15091   85 TSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLggTKVREDVDSTECSLQFPDDDYSWWD 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IrhhVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRH--------FWTILVVVVAFVVCWTPYHLFSIWElTI 272
Cdd:cd15091  165 T---FMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREkdrnlrriTRLVLVVVAVFVVCWTPIHIFILVE-AL 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 387763613 273 HHNSYSHHVMQAGIpLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15091  241 GSVSHSTAAVSSYY-FCIALGYTNSSLNPILYAFLDENFKRCF 282
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
43-315 1.58e-28

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 112.09  E-value: 1.58e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFK---WKKTvtTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQL 119
Cdd:cd15375    5 VMYSIIFIVGFPGNIIAIFVYLFKmrpWKSS--TIIMLNLALTDLLYVTSLPFLIYYYINGESWIFGEFMCKFIRFIFHF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 120 NMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLT 199
Cdd:cd15375   83 NLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFLITTKEKNNRTICLDFTSSDNLNTI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 LirhhVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISS---RHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNS 276
Cdd:cd15375  163 W----WYNWILTVLGFLLPLVIVTLCYTRIIYTLAKGPHTGSAskqKARRLIILILLVFYVCFLPFHILRVVRIETRLPP 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 387763613 277 YSHHVMQ---AGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15375  239 VSCCLKHqvhAIYIITRPLAALNTFGNLLLYVVSGDNFQQAF 280
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
43-315 2.70e-28

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 111.05  E-value: 2.70e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFT-GFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFhWPFGIWLCKANSFTAQLNM 121
Cdd:cd15974    5 VIYLLVCAIGLSGNTLVIYVVlRYAKMKTVTNIYILNLAVADELFMLGLPFLATQNAISY-WPFGSFLCRLVMTVDGVNQ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDtVEFNNHTlCYNNFqkhdPDLTLI 201
Cdd:cd15974   84 FTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFSD-VQPDLNT-CNISW----PEPVSV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISS--------RHFWTILVVVVAFVVCWTPYHLFSIWELTih 273
Cdd:cd15974  158 WSTAFIIYTAVLGFFGPLLVICLCYLLIVIKVKSSGLRVGStkrrkserKVTRMVVIIVVVFVFCWLPFYMLNIVNLI-- 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 387763613 274 hnsyshhVMQAGIPLSTGLAFL-------NSCLNPILYVLISKKFQARF 315
Cdd:cd15974  236 -------VILPEEPAFVGVYFFvvvlsyaNSCANPILYGFLSDNFKQSF 277
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
40-315 5.65e-28

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 110.47  E-value: 5.65e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfHWPFGIWLCKANSFTAQ 118
Cdd:cd15090    2 TIMALYSIVCVVGLFGNFLVMYvIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMG-TWPFGNILCKIVISIDY 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFqkhdPDL 198
Cdd:cd15090   81 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTF----SHP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 TLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISS--------RHFWTILVVVVAFVVCWTPYHLFSIWEL 270
Cdd:cd15090  157 SWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSkekdrnlrRITRMVLVVVAVFIVCWTPIHIYVIIKA 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 387763613 271 TIHHNSYSHHVMQAGIPLSTGlaFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15090  237 LVTIPETTFQTVSWHFCIALG--YTNSCLNPVLYAFLDENFKRCF 279
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
43-319 8.86e-28

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 111.02  E-value: 8.86e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMnFHWPFGIWLCKANSFTAQLNMF 122
Cdd:PHA03087  45 VVYSTIFFFGLVGNIIVIYVLTKTKIKTPMDIYLLNLAVSDLLFVMTLPFQIYYYIL-FQWSFGEFACKIVSGLYYIGFY 123
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLir 202
Cdd:PHA03087 124 NSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTPILFVYTTKKDHETLICCMFYNNKTMNWKL-- 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 203 hhvltWVKF---IIGYLFPLLTMSICYLCLIFKVKKRSILISS-RHFWTILVVVVAFVVCWTPYH----LFSIWELTIHH 274
Cdd:PHA03087 202 -----FINFeinIIGMLIPLTILLYCYSKILITLKGINKSKKNkKAIKLVLIIVILFVIFWLPFNvsvfVYSLHILHFKS 276
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 387763613 275 NSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARFRSSV 319
Cdd:PHA03087 277 GCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSL 321
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
43-315 1.29e-27

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 109.39  E-value: 1.29e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKK-TVTTLWFLNLAIADFIFLLFLPLYISYVAMNfhWPFGIWLCKANSFTAQLNM 121
Cdd:cd15180    5 VLYSLVFLLGLLGNGLVLAVLLQKRRNlSVTDTFILHLALADILLLVTLPFWAVQAVHG--WIFGTGLCKLAGAVFKINF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTV--EFNNHTLCYNNFqkhdPDLT 199
Cdd:cd15180   83 YCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFLEATkdPRQNKTECVHNF----PQSD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 LIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSI-LISSRHFWTILVVVVAFVVCWTPYHLFSIWEL-----TIH 273
Cdd:cd15180  159 TYWWLALRLLYHIVGFLLPLAVMVYCYTSILLRLLRSSQgFQKQRAIRVIVAVVVVFFLCWTPYNIALLVDTlidlsVLD 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 387763613 274 HNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15180  239 RNCGTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFRRKL 280
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
43-314 3.20e-27

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 108.31  E-value: 3.20e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKK-TVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd16001    5 VTYSVVFVLGLPLNGTVLWLSWCRTKRwTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRDRWPFGDFLCKLVRFLFYTNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYN-----NFQKHDP 196
Cdd:cd16001   85 YGSILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVYARTGSINNRTVCYDltspdNFGNYFP 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 DLTlirhhVLTwvkfIIGYLFPLLTMSICYlCLIFKVKKRSI-------LISSRHFWTILVVVVAFVVCWTPYHLF-SIW 268
Cdd:cd16001  165 YGM-----VLT----VTGFLIPFLIILLCY-CLMIKSLIRSEeaagvgkAARAKSIRTILLVCGLFALCFVPFHITrTIY 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 387763613 269 ELTIHHNSYSHHVMQA---GIPLSTGLAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd16001  235 LFVRVYLVQDCPLLQFvslAYKIWRPLVSFNSCINPLLYFLSGDSNRLR 283
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
40-315 4.18e-27

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 107.88  E-value: 4.18e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVI---WFTGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNfHWPFGIWLCKANSF 115
Cdd:cd15002    1 LVPILLGVICLLGFAGNLMVIgilLNNARKGKPSLIDSLILNLSAADLLLLLFsVPFRAAAYSKG-SWPLGWFVCKTADW 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 116 TAQLNMFASVFFLTVISLDHYIHLIHPVlSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHD 195
Cdd:cd15002   80 FGHACMAAKSFTIAVLAKACYMYVVNPT-KQVTIKQRRITAVVASIWVPACLLPLPQWLFRTVKQSEGVYLCILCIPPLA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 196 PDLTLIrhhvLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILI--------SSRHFWTILVVVVAFVVCWTPYHLFSI 267
Cdd:cd15002  159 HEFMSA----FVKLYPLFVFCLPLTFALFYFWRAYGQCQRRGTKTqnlrnqirSRKLTHMLLSVVLAFTILWLPEWVAWL 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 387763613 268 WEltIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15002  235 WL--IHIKSSGSSPPQLFNVLAQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
49-314 6.81e-27

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 107.55  E-value: 6.81e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  49 FVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFF 127
Cdd:cd15189   11 CLFGLLGNLFVLLvFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNQFNWPFGELLCRVVNGVIKVNLYTSIYL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 128 LTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNH--TLCYNNFQKHDPDLTlirHHV 205
Cdd:cd15189   91 LVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAIPDLniTACVLLYPHEAWHFA---HIV 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 206 LTwvkFIIGYLFPLLTMSICYLCLIFKVKKRS------ILISSRHFWTILVVVVAFVVCWTPYHLFSIWE----LTIHHN 275
Cdd:cd15189  168 LL---NIVGFLLPLLVITFCNYNILQALRTREestrceDRNDSKATALVLAVTLLFLVCWGPYHFFTFLDflfdVGVLDE 244
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 387763613 276 SYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd15189  245 CFWEHFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFRRK 283
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
43-315 1.00e-26

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 107.31  E-value: 1.00e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYvAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15155    5 AVYSVVFILGLITNCASLFVFCFRMKmRNETAIFMTNLAVSDLLFVFTLPFKIFY-NFNRHWPFGDSLCKISGTAFLTNI 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLI 201
Cdd:cd15155   84 YGSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCFEGFSKSIWKTYLS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RhhvLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILI-----SSRHFWTILVVVVAFVVCWTPYH----LFSIWELTI 272
Cdd:cd15155  164 K---ITIFIEVVGFIIPLLLNLTCSSLVLRTLRKPATLSqigtnKEKVLKMILVHVAIFVVCFVPYNsilfLYALVRSQA 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 387763613 273 HHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15155  241 IANCGVERFARTMYPITLCLATLNCCFDPFVYYFTSESFQKSF 283
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
43-313 1.27e-26

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 106.81  E-value: 1.27e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMnfHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15187    5 VLYCLLFVFGLLGNSLVIWvLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQAYYLLD--QWVFGNAMCKIVSGAYYIGF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLI 201
Cdd:cd15187   83 YSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVASEDGRLQCIPFYPGQGNSWKVF 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTwvkfIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYH----LFSIWELTIHHNSY 277
Cdd:cd15187  163 TNFEVN----ILGLLIPFSILIFCYHNILRNLRRCHNQNKTKAIKLVFIVVIVFFLFWTPFNvvlfLDSLHSLHIIDGCQ 238
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 387763613 278 SHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQA 313
Cdd:cd15187  239 NSQRLTLALHLTETISFTHCCLNPVIYAFVGEKFKK 274
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
42-315 2.08e-26

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 106.38  E-value: 2.08e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAFVLGIPGNA-IVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfhWPFGIWLCKANSFTAQLN 120
Cdd:cd15172    4 PVIYSLICVVGLIGNSlVVITYAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVYEAHQ--WIFGNFSCKLLRGIYAIN 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHR--TLKNSLIVIIFIWLLASLIGGPALYFRDTVEF--NNHTLCYNNFQKhdp 196
Cdd:cd15172   82 FYSGMLLLACISVDRYIAIVQATKSFRLRsrTLAYSKLICAAVWLLAILISLPTFIFSEVYDFglEEQYVCEPKYPK--- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 DLTLIRHHVLTW-VKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWE---LTI 272
Cdd:cd15172  159 NSTAIMWKLLVLsLQVSLGFFIPLLVMIFCYSFIIKTLLQAQNSQRHKAVRVVVAVVLVFLVCQVPYNIVLLIEainLGE 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 387763613 273 HHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15172  239 QQSCSSEKAVAYAKTITECLAFFHCCLNPVLYAFIGVKFRNYF 281
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
44-314 2.19e-26

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 106.37  E-value: 2.19e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGN--AIVIWFTGFKwKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15158    6 LYSVITVFGLVGNgfALYVLIKTYR-QKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKGQWLFGDFLCRISSYALYVNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCynnFQKHDPDLTLI 201
Cdd:cd15158   85 YCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFLMSGSHDTETNKTKC---FEPPQSNQQLT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILIS------SRHFWTILVVVVAFVVCWTPYHLfsiwELTIHHN 275
Cdd:cd15158  162 KLLVLNYISLVVGFIIPFLVILICYAMIIRTLLKNTMKARkqqssrKKAIRMIIIVLLAFLVSFMPYHI----QRTIHLH 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 387763613 276 SYSHH--------VMQAGIPLSTGLAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd15158  238 FLSRKdstceevlYMQKSVVITLCLAAANCCFDPLLYFFSGENFRRR 284
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
43-315 2.40e-26

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 105.99  E-value: 2.40e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15162    5 AVYTLVFVVGLPANGMALWVLLFRTKkKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVAFYGNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTvefnnhtlcynnFQKHDPDLTLI 201
Cdd:cd15162   85 YCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQT------------IFLPALDITTC 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 rHHVLTWVK------------FIIGYLFPLLTMSICYLCLIFKVKKRSILIS-SRHFWTI---LVVVVAFVVCWTPYHLF 265
Cdd:cd15162  153 -HDVLPEQLlvgdwfyyflslAIVGFLIPFILTASCYVATIRTLAALEDENSeKKKKRAIklaATVLAIFIICFAPSNLL 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 387763613 266 siweLTIHHNSYSHHVMQAGIP---LSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15162  232 ----LLAHYSLISSSGTGHLYFaylLALCLSTLNSCIDPFIYYFVSKEFRDHV 280
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
45-314 2.63e-26

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 106.01  E-value: 2.63e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  45 YCLAFVLGIPGNAIVIWFTGFKWKK-TVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFA 123
Cdd:cd15968    7 YSFVFLLGLPLNSVVLTRCCRHTKAwTRTAIYMVNLALADLLYALSLPLLIYNYAMRDRWLFGDFMCRLVRFLFYFNLYG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 124 SVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNfqkhDPDLTLIRH 203
Cdd:cd15968   87 SILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTVCYDL----APPALFPHY 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 204 HVLTWVKFIIGYLFPLLTMSICY---LCLIFKVKKRSILISS----RHFWTILVVVVAFVVCWTPYHLF-SIWELTIHHN 275
Cdd:cd15968  163 VPYGMALTVSGFLLPFSIILWCYclvVRTLCRTLGPAEPPAQarrrKSIRTIVTVTLLFALCFLPFHITrTIYLAVRVTP 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 387763613 276 SYSHHVMQAGIPLSTG---LAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd15968  243 GVPCHVLEAVAACYKItrpLASANSVLNPLLYFLTKKKFGRR 284
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
44-315 2.87e-26

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 106.15  E-value: 2.87e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIWFTGFKWKK-TVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15377    6 VYILVFITGFLGNSVAIWMFVFHMKPwSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIFHVNLY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDT-VEFNNHTLCYNNfqkhDPDLTLI 201
Cdd:cd15377   86 GSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTgVRKNKTITCYDT----TSDEYLR 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWVKFIIGYLFPLLTMSICY----LCLIFKVKKRSILISS----RHFWTILVVVVAFVVCWTPYHLFSIWELTIH 273
Cdd:cd15377  162 SYFIYSMCTTVAMFCVPFILILGCYglivRALIYKDMKYTEENNAplrrKSIYLVIIVLTVFAVSYLPFHVMKTLNLRAR 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 387763613 274 HNSYSHHV------MQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15377  242 LDFQTPAMcafndrVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRL 289
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
52-314 4.06e-26

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 105.28  E-value: 4.06e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  52 GIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVI 131
Cdd:cd15339   14 GLVGNILVLFTIIRSRKKTVPDIYVCNLAVADLVHIIVMPFLIHQWARGGEWVFGSPLCTIITSLDTCNQFACSAIMTAM 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 132 SLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHT-LCYNNFQKhdPDLTLIRHHVLTwvk 210
Cdd:cd15339   94 SLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFRDGLeSCAFNLTS--PDDVLWYTLYQT--- 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 211 fIIGYLFPLLTMSICY---LCLIFKVKKRSILISS-----------RHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNS 276
Cdd:cd15339  169 -ITTFFFPLPLILICYiliLCYTWEMYRKNKKAGRyntsiprqrvmRLTKMVLVLVGVFLVSAAPYHVIQLVNLSVSQPT 247
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 387763613 277 YSHHVmqaGIPLSTGLAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd15339  248 LAFYV---SYYLSICLSYASSSINPFLYILLSGNFRKR 282
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
43-314 4.08e-26

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 105.66  E-value: 4.08e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKK-TVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15374    5 VSYGLVFVVGLPLNATALWLFIKRMRPwNPTTVYMFHLALSDTLYVLSLPTLIYYYADHNHWPFGVVACKIVRFLFYANL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDltli 201
Cdd:cd15374   85 YCSILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSRKDNITLCHDTTRPEEFD---- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 rhHVLTWVKFIIGYLF--PLLTMSICYLCLIFKVKKRSILISS--------RHFWTILVVVVAFVVCWTPYHLFSIWELT 271
Cdd:cd15374  161 --HYVHYSSAVMVLLFgiPCLVIVVCYGLMARRLCKPRVGSSRqqgpsskkRSLKTIIMVLTVFAICFVPFHITRTLYYV 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 387763613 272 ---IHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd15374  239 arlLKADCDTLNIINVTYKVTRPLASANSCLDPILYFLAGDKYRRR 284
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
43-315 4.49e-26

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 105.18  E-value: 4.49e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWK--KTVTTLWFlNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15922    5 VFLSLVFLGGFLLNSFSLWIFWFRIKqwSSGTILQF-NLALSDAIITPAAPLLIAYFSLGSHWPFGQFLCQLKVFLLSTH 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHpvLSHRHRTLKNSLI--VIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNnfqKHDPDL 198
Cdd:cd15922   84 MYGSIYFLMLISIHRYVTVVH--YNWKSLWKKKSFMkkLCLGVWLLLFVQGLPFFFVLKTSVIDGKTKCLS---IHQSEL 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 TLIrHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKK------RSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTI 272
Cdd:cd15922  159 SLL-YFVWNFVLLILGFLLPFGVSLTCYALLGASIAKmnsnnaRGRAMKAKSLQMIGISLVIFIICFVPLHVTRTVGVVV 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 387763613 273 HH----NSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15922  238 KLfypeSCTLLHKVEVAYYISWVLTGVNCCLDPLLYCFASEKFRKSF 284
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
43-312 9.01e-26

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 104.44  E-value: 9.01e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfhWPFGIWLCKANSFTAQLNM 121
Cdd:cd15176    5 VFYTIALVVGLAGNSLVVAiYAYYKKLKTKTDVYILNLAVADLLLLFTLPFWAADAVNG--WVLGTAMCKITSALYTMNF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHpvLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLI 201
Cdd:cd15176   83 SCGMQFLACISVDRYVAITK--ATSRQFTGKHCWIVCLCVWLLAILLSIPDLVFSTVRENSDRYRCLPVFPPSLVTSAKA 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLtwvKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWE------LTIHHN 275
Cdd:cd15176  161 TIQIL---EVLLGFVLPFLVMVFCYSRVARALSRTPNVKKSRALKVLLAVVGVFIVTQLPYNVVKFYRaidviyLLITDC 237
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 387763613 276 SYSHHvMQAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15176  238 SMSKT-LDIAIQVTESIALFHSCLNPVLYVFMGASFK 273
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
43-315 9.27e-26

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 104.44  E-value: 9.27e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15087    5 VIYSVICAVGLTGNTAVIYVILRAPKmKTVTNVFILNLAIADDLFTLVLPINIAEHLLQ-QWPFGELLCKLILSIDHYNI 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHR--HRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTL-CYNNFQKHDPD- 197
Cdd:cd15087   84 FSSIYFLTVMSVDRYLVVLATVRSRRmpYRTYRAAKIVSLCVWLLVTIIVLPFTVFAGVYSNELGRKsCVLSFPSPESLw 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 LTLIRHHVLtwvkfIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHF--------WTILVVVVAFVVCWTPYHLFSIWE 269
Cdd:cd15087  164 FKASRIYTL-----VLGFAIPVSTICILYTMMLYKLRNMRLNSNAKALdkakkkvtLMVLVVLAVCLFCWTPFHLSTVVA 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 387763613 270 LTihhNSYSHHVMQAGIPLS-TGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15087  239 LT---TDLPQTPLVIGISYFiTSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
45-312 1.29e-25

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 104.09  E-value: 1.29e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  45 YCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYIsyVAMNFHWPFGIWLCKANSFTAQLNMFA 123
Cdd:cd15177    7 YLVVFVLGLVGNGLVLAtHTRYRRLRSMTDVYLLNLALADLLLLLTLPFAA--AETLQGWIFGNAMCKLIQGLYAINFYS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 124 SVFFLTVISLDHYIHLIHPVLSHRHR--TLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFqkhdPDLTLI 201
Cdd:cd15177   85 GFLFLTCISVDRYVVIVRATSAHRLRpkTLFYSVLTSLIVWLLSILFALPQLIYSRVENRSELSSCRMIF----PEVVSR 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWV-KFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYSHH 280
Cdd:cd15177  161 TVKGATALtQVVLGFAIPLIVMAVCYAAIGRTLLAARGWERHRALRVIAALVVAFVLFQLPYSVVLLLDTADLLATLELS 240
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 387763613 281 VMQA-----GIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15177  241 CSQSkrkdiALLVTSGLAYVRCCLNPLLYAFVGVRFR 277
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
43-315 2.66e-25

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 103.05  E-value: 2.66e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKK-TVTTLWFLNLAIADFIFLLF-LPLYIsYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd14969    5 VYLSLIGVLGVVLNGLVIIVFLKKKKLrTPLNLFLLNLALADLLMSVVgYPLSF-YSNLSGRWSFGDPGCVIYGFAVTFL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRhRTLKNSLIVIIFIWLLASLIGGPALYF--RDTVEFNNHTlCYNNFQKHDP-D 197
Cdd:cd14969   84 GLVSISTLAALAFERYLVIVRPLKAFR-LSKRRALILIAFIWLYGLFWALPPLFGwsSYVPEGGGTS-CSVDWYSKDPnS 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 LTLIrhhvltWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISS---------------RHFWTILVVVVAFVVCWTPY 262
Cdd:cd14969  162 LSYI------VSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARrknsaitkrtkkaekKVAKMVLVMIVAFLIAWTPY 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 387763613 263 HLFSIWELTIHHNSYSHHVMQagipLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd14969  236 AVVSLYVSFGGESTIPPLLAT----IPALFAKSSTIYNPIIYVFMNKQFRRAL 284
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
43-312 6.44e-25

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 104.32  E-value: 6.44e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPlYISYVAMNfHWPFGIWLCKANSFTAQLNMF 122
Cdd:PHA02638 103 IFYIIIFILGLFGNAAIIMILFCKKIKTITDIYIFNLAISDLIFVIDFP-FIIYNEFD-QWIFGDFMCKVISASYYIGFF 180
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRD------TVEFNNHTL----CYNNFQ 192
Cdd:PHA02638 181 SNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAYFIFEasniifSAQDSNETIsnyqCTLIED 260
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 193 KHDPDLTLIRhHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTI 272
Cdd:PHA02638 261 NEKNNISFLG-RILQFEINILGMFIPIIIFAFCYIKIILKLKQLKKSKKTKSIIIVSIIIICSLICWIPLNIVILFATMY 339
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 387763613 273 HHNSYSH-------HVMQAG--IPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:PHA02638 340 SFKGFNSiisehicGFIKLGyaMMLAEAISLTHCCINPLIYTLIGENFR 388
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
39-312 8.76e-25

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 101.77  E-value: 8.76e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfhWPFGIWLCKANSFTA 117
Cdd:cd15175    1 WFLPAMYSVICFLGLLGNGLVILtYIYFKRLKTMTDIYLLNLALADILFLLTLPFWAASAAKK--WVFGEEMCKAVYCLY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 118 QLNMFASVFFLTVISLDHYIHLIHPVLSHRHR--TLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCyNNFQKHD 195
Cdd:cd15175   79 KMSFFSGMLLLMCISIDRYFAIVQAASAHRHRsrAVFISKVSSLGVWVLAFILSIPELLYSGVNNNDGNGTC-SIFTNNK 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 196 PDLTLIrhhvLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHN 275
Cdd:cd15175  158 QTLSVK----IQISQMVLGFLVPLVVMSFCYSVIIKTLLQARNFEKNKAIKVIIAVVVVFVVFQLPYNSVMLVSTLSSFK 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 387763613 276 SYSHHV-----MQAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15175  234 GNTTDCdysknLDFALDVTYSLACFRCCLNPFLYAFIGVKFR 275
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
43-312 9.31e-25

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 101.76  E-value: 9.31e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWfTGFKWKKT--VTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd14987    5 FFYIFIFVIGLLANSVVVW-VNLQAKRTgyETHLYILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTCKITHLIFSIN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTV--EFNNHTLCYNNFQKHDPDL 198
Cdd:cd14987   84 LFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDTYFLKTVtsPSNNETYCRSFYPEESFKE 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 TLIRhhvLTWVKFIIGYL--FPLLTMSICYLCLIFKVKKRSILISSRHFwtILVVVVAFVVCWTPYH------LFSIWEL 270
Cdd:cd14987  164 WLIG---MELVSIVLGFVipFPIIAVFYFLLARAISASSDQERKSSRKI--IFSYVVVFLVCWLPYHtvvlldILSFLHL 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 387763613 271 tIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd14987  239 -IPFSCQLENFLYAALHVTQCFSLVHCCVNPILYSFINRNYR 279
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
44-311 1.16e-24

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 101.33  E-value: 1.16e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIW---FTGFKWKKTvtTLWFLNLAIADFIFLLFLPLYISYVAmNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15378    6 MYSIEFVLGFIGNTIVILgyiFCLKNWKSS--NIYLFNLSVSDLAFLCTLPMLVYSYS-NGQWLFGDFLCKSNRYLLHAN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTL 200
Cdd:cd15378   83 LYSSILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWVLVTLELLPILTFIGPNLKDNVTKCKDYASSGDATNSL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRHHVLTwvkfIIGYLFPLLTMSICYLCLIFKVKKRSILISS-----RHFWTILVVVVAFVVCWTPYHLFSIWELTIHHN 275
Cdd:cd15378  163 IYSLFLT----VTGFLIPLCVMCFFYYKIALFLKNRNRQLANatsfeKPLTLVILAVVIFSVLFTPYHVMRNVRIASRLD 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 387763613 276 SY-----SHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKF 311
Cdd:cd15378  239 SIgvsecTLIIIKSLYIVTRPIAFLNSVINPVFYFLMGDHF 279
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
44-312 1.54e-24

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 101.06  E-value: 1.54e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15185    6 LYSLVFIVGLLGNVVVVViLIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVRWN-NWVFGHGMCKLLSGFYYLGLY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDlTLIR 202
Cdd:cd15185   85 SEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQELFEEFLCSPLYPEDTED-SWKR 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 203 HHVLTWVkfIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYH---LFSIWELTIHHNS--Y 277
Cdd:cd15185  164 FHALRMN--IFGLALPLLIMVICYTGIIKTLLRCPSKKKYKAIRLIFVIMVVFFIFWTPYNlvlLLSAFQSIFFETDceR 241
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 387763613 278 SHHvMQAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15185  242 SKH-LDLAMQVTEVIAYTHCCINPVIYAFVGERFR 275
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
43-312 2.26e-24

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 100.51  E-value: 2.26e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYvaMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15182    5 VFYYLVFLLSLLGNGLVLWiLVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASY--HSSGWIFGEILCKAVTSIFYIGF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVefnnhtlcynnfqKHDPDLTLI 201
Cdd:cd15182   83 YSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVM-------------KSDEDGSLC 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWVK-----FIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYH----LFSIWELTI 272
Cdd:cd15182  150 EYSSIKWKLgyyyqQNLFFLIPLGIIVYCYVRILQTLMRTRTMRKHRTVKLIFVIVLVFFLSWAPYNivifLRSLKDLTI 229
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 387763613 273 HHNSYSHHVMQAgIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15182  230 PICECSKQLDYA-FYICRNIAFSHCCLNPVFYVFVGVKFR 268
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
39-311 2.88e-24

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 100.10  E-value: 2.88e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIWFTGFKWKK-TVTTLWFLNLAIADFIFLLFLPLYIsyVAMNFHWPFGIWLCkanSFTA 117
Cdd:cd15165    1 SLQLVVYIPTFVLGLLLNLMALWVFLFKIKKwTESTIYMINLALNDLLLLLSLPFKM--HSSKKQWPLGRTLC---SFLE 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 118 QL---NMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDtvEFNNHTLCYNNFQKH 194
Cdd:cd15165   76 SLyfvNMYGSILIIVCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIPIYSFHD--KPTNNTRCFHGFSNK 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 195 DPDLTLIrhhvltWVKFIIGYLFPLLTMSICYLCLIFKVKKRSI-----LISSRHFWTILVVVVAFVVCWTPYHL-FSIW 268
Cdd:cd15165  154 TWSKKVI------VVVEEFGFLIPMAVMVFCSVQIIRTLLDMRRpeqpkVKQNKSVKIVLSNLVVFLVCFTPYHLgIFLQ 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 387763613 269 ELT---IHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKF 311
Cdd:cd15165  228 FLVkndIINDCSTKQSIRLFVQVSMCLANVNCCLDAICYYFILKEF 273
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
43-311 3.59e-24

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 100.21  E-value: 3.59e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd14991    5 PLLILEFVLGLPGNVVALWIFCFHSRtWKANTVYLFNLVLADFLLLICLPFRIDYYLRGEHWIFGEAWCRVNLFMLSVNR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLI 201
Cdd:cd14991   85 SASIAFLTAVALDRYFKVVHPHHRVNRMSVKAAAGVAGLLWALVLLLTLPLLLSTLLTVNSNKSSCHSFSSYTKPSLSIR 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLtwvkFIIGYLFPLLTMSICYLCLIFKVKKRSILIS----SRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSY 277
Cdd:cd14991  165 WHNAL----FLLEFFLPLGLIVFCSVRIACNLRIRQSLGKqarvQRAIRLVFLVVIVFVLCFLPSIIAGLLALVFKNLGS 240
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 387763613 278 SHHVMQAGIPLSTGLAF--LNSCLNPILYVLISKKF 311
Cdd:cd14991  241 CRCLNSVAQLFHISLAFtyLNSALDPVIYCFSSPWF 276
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
43-311 5.24e-24

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 99.83  E-value: 5.24e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKK-TVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15373    5 VSYGIVFVVGLVLNILALYVFLFRTKPwNASTTYMFNLAISDTLYVLSLPLLVYYYADENDWPFSEALCKIVRFLFYTNL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLI 201
Cdd:cd15373   85 YCSILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVTTSDKGGNITCHDTSSPELFDQFVV 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWVKFIIgylfPLLTMSICYLCLIFKVKKRSILISSR------HFWTILVVVVAFVVCWTPYHL-------FSIW 268
Cdd:cd15373  165 YSSVMLVLLFCV----PFVVILVCYALMVRKLLKPSAGTSTNsrskkkSVKMIIIVLAVFILCFLPFHVtrtlyysFRSM 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 387763613 269 ELTIHHNSYSHHVMQAGIPlstgLAFLNSCLNPILYVLISKKF 311
Cdd:cd15373  241 DLSCGTLNAINLAYKVTRP----LASANSCLDPILYFLAGQSF 279
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
44-304 9.85e-24

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 99.00  E-value: 9.85e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIWFTGFKWKKTVTT--LWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15376    6 ILGVEFLVAVLGNGLALWLFVTRERRPWHTgvVFSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLFTCNL 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDT-VEFNNHTLCYNNfqKHDPDLTL 200
Cdd:cd15376   86 YGSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALSAPVLSFSHLeVERHNKTECLGT--AVDSRLPT 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRHHvlTWVKFIIGYLFPLLTMSICYLCLIFKV-KKRSILISSRHFWTILVVVVAFV--VCWTPYHLFSIWELTIH-HNS 276
Cdd:cd15376  164 YLPY--SLFLAVVGCGLPFLLTLASYLAIVWAVlRSPGITTLEKRKVAALVAVVVALyaVSFVPYHILRNLNLYRRlQWL 241
                        250       260       270
                 ....*....|....*....|....*....|
gi 387763613 277 YSHHVMQA--GIPLSTGLAFLNSCLNPILY 304
Cdd:cd15376  242 KAAASLRIyfAYQVTKGLVTLNMCIHPLLY 271
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
40-315 9.87e-24

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 99.04  E-value: 9.87e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNfHWPFGIWLCKANSFTA 117
Cdd:cd14992    2 ILGVALVVIILVSVVGNFIVIAaLARHKNLRGATNYFIASLAISDLLMALFcTPFNFTYVVSL-SWEYGHFLCKIVNYLR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 118 QLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGP-ALYFRDTVEFNNHTLCYNNFQKHDP 196
Cdd:cd14992   81 TVSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPqLYYATTEVLFSVKNQEKIFCCQIPP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 DLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISS-------------RHFWTILVVVVAFVVCWTPYH 263
Cdd:cd14992  161 VDNKTYEKVYFLLIFVVIFVLPLIVMTLAYARISRELWFRKVPGFSikeverkrlkckrRVIKMLVCVVVLFVICWLPFH 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 387763613 264 LFSIWELTIHHNSYSHHVMQAGIPLSTgLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd14992  241 LFFLLRDFFPLIMKEKHTLQVYYFLHW-IAMSNSMYNPIIYVTLNNNFRKNF 291
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
42-312 1.21e-23

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 98.67  E-value: 1.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15012    3 IILYTLVFCCCFFGNLLVILvVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLS 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEfNNHTLCYNNFQKHDPDLTL 200
Cdd:cd15012   83 YTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVE-ILVTQDGQEEEICVLDREM 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAF-VVCWTPYHLFSIWELTIHHNSYSH 279
Cdd:cd15012  162 FNSKLYDTINFIVWYLIPLLIMTVLYSKISIVLWKSSSIEARRKVVRLLVAVVVSfALCNLPYHARKMWQYWSEPYRCDS 241
                        250       260       270
                 ....*....|....*....|....*....|...
gi 387763613 280 HVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15012  242 NWNALLTPLTFLVLYFNSAVNPLLYAFLSKRFR 274
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
44-312 1.23e-23

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 98.77  E-value: 1.23e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15156    6 VFSMVFVLGLIANCVAIYIFMCTLKvRNETTTYMINLAISDLLFVFTLPFRIFYFVQR-NWPFGDLLCKISVTLFYTNMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEF--NNHTLCYNNFQKHDPDLTL 200
Cdd:cd15156   85 GSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASFFQSTNNQlnNNSETCFENFSSKTWKTYL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRhhVLTWVKfIIGYLFPLLTMSICYLCLIFKVKK-----RSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHN 275
Cdd:cd15156  165 SK--IVIFIE-IVGFFIPLILNVTCSTMVLKTLRRpntlsRSKLNKKKVLKMIFVHLFIFCFCFIPYNVNLVLYSLVRTQ 241
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 387763613 276 SYSHHVMQAGI----PLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15156  242 TFKNCSVVAAVrtmyPITLCIAVSNCCFDPIVYYFTSETIQ 282
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
41-314 1.51e-23

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 98.36  E-value: 1.51e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  41 SLVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfHWPFGIWLCKANSFTAQL 119
Cdd:cd15166    3 ALVFYSFIFIIGLFVNITALWvFSCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVYYAKD-EWPFGDYFCRILGALTVF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 120 NMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYF-RDTVEFNNHTLCYNNFqkhdpDL 198
Cdd:cd15166   82 YPSIALWLLAFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPLLFLyEDPDKASNFTTCLKML-----DI 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 TLIRH-HVLTWVKFIIGYLFPLLTMSICYLCLIF------------KVKKRSILIssrhfwtILVVVVAFVVCWTPYHL- 264
Cdd:cd15166  157 IHLKEvNVLNFTRLIFFFLIPLFIMIGCYLVIIHnlvhgrtsklkpKVKEKSIRI-------IITLIVQVLVCFVPFHIc 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 387763613 265 FSIWELTIHHNSYShhvmqAGIPLSTGLAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd15166  230 FAFLMLQNGDNSYN-----PWAAFTTFLMNLSTCLDVILYYIVSKQFQAR 274
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
43-312 1.91e-23

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 97.90  E-value: 1.91e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfhWPFGIWLCKANSFTAQLNM 121
Cdd:cd15181    5 LAYSLVFLLGVVGNGLVLTiLLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIAG--WVFGTFLCKLVGAIHKLNF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRD--TVEFNNHTLC-YNNFQKHDPDL 198
Cdd:cd15181   83 YCSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNLVFLEveTSTNANRTSCsFHQYGIHESNW 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 TLirhhVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSI-LISSRHFWTILVVVVAFVVCWTPYHLFSIWEL-----TI 272
Cdd:cd15181  163 WL----TSRFLYHVVGFFLPLLIMGYCYATIVVTLCQSSRrLQKQKAIRVAILVTLVFCLCWLPYNIVIFLDTlddlkAV 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 387763613 273 HHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15181  239 VKNCKLNDLLDAAITVTESLGFSHCCLNPILYAFIGVKFR 278
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
43-315 2.01e-23

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 97.95  E-value: 2.01e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFhWPFGIWLCKANSFTAQLNM 121
Cdd:cd15972    5 LVYLVVCVVGLGGNTLVIYVVLRYSAsESVTNIYILNLALADELFMLGLPFLAAQNALSY-WPFGSFMCRLVMTVDAINQ 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNhtLCYNNFqkhdPDLTLI 201
Cdd:cd15972   84 FTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMG--TCHIAW----PEPAQV 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVK---KRSILISSRHFWT-------ILVVVVAFVVCWTPYHLFSIWELT 271
Cdd:cd15972  158 WRAGFIIYTATLGFFCPLLVICLCYLLIVVKVRssgRRVRATSTKRRGSerkvtrmVVIVVAAFVLCWLPFYALNIVNLV 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 387763613 272 IHHNSYSHHvmQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15972  238 CPLPEEPSL--FGLYFFVVVLSYANSCANPIIYGFLSDNFKQGF 279
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
45-312 2.21e-23

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 97.94  E-value: 2.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  45 YCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVaMNFHWPFGIWLCKANSFTAQLNMFA 123
Cdd:cd15153    7 YIIIFIPGLLANSAALWvLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYY-IQHTWPFGRFLCLLCFYLKYLNMYA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 124 SVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIfIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLIRh 203
Cdd:cd15153   86 SICFLTCISIQRCFFLLHPFKARDWKRRYDVGISAA-VWIVVGLACLPFPLLRSKSLSNNNRSCFADLGMKKLNFGAAI- 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 204 hVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKR-----SILISSRHFWTILVVVVAFVVCWTPYH----LFSIWELTIHH 274
Cdd:cd15153  164 -AMMTVAELFGFVIPLFIIAWCTWKTENSLRQRnkqqqSTSEKQKALRMVRMCAAVFFICFAPYHinflFYLMVSESIIT 242
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 387763613 275 NSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15153  243 NCEVSQVILQFHPISLCLASLNCCLDPILYYFMTSEFQ 280
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
44-312 3.92e-23

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 97.13  E-value: 3.92e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfhWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15184    6 LYSLVFIFGFVGNMLVVLiLINCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANE--WVFGNAMCKLLTGLYHIGFF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQkhdPDLTLIR 202
Cdd:cd15184   84 SGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGIIFTKSQKEGSHYTCSPHFP---PSQYQFW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 203 HHVLTWVKFIIGYLFPLLTMSICYlCLIFKVKKRSILISSRH--FWTILVVVVAFVVCWTPYH----LFSIWELTIHHNS 276
Cdd:cd15184  161 KNFQTLKMNILGLVLPLLVMIICY-SGILKTLLRCRNEKKRHkaVRLIFTIMIVYFLFWAPYNivllLNTFQEFFGLNNC 239
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 387763613 277 YSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15184  240 SSSNRLDQAMQVTETLGMTHCCINPVIYAFVGEKFR 275
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
39-315 5.27e-23

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 96.69  E-value: 5.27e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLF-LPL-YISYVAMNFhwPFGIWLCKANSF 115
Cdd:cd15206    1 ELIIPLYSVIFLLAVVGNILVIVtLVQNKRMRTVTNVFLLNLAVSDLLLAVFcMPFtLVGQLLRNF--IFGEVMCKLIPY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 116 TAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHtlCYNNFQKHD 195
Cdd:cd15206   79 FQAVSVSVSTFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRP--GGHKCREVW 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 196 PDltliRHHVLTWVKFIIGYLF--PLLTMSICYLCL---IFKVKKRSIlissRHFWTILvvvVAFVVCWTPYHLFSIWEL 270
Cdd:cd15206  157 PN----EIAEQAWYVFLDLMLLviPGLVMSVAYGLIswtLLEAKKRVI----RMLFVIV---VEFFICWTPLYVINTWKA 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 387763613 271 tIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15206  226 -FDPPSAARYVSSTTISLIQLLAYISSCVNPITYCFMNKRFRQAF 269
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
43-269 5.96e-23

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 96.76  E-value: 5.96e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15367    5 VVYILVLVVGLPANCLSLYYGYLQIKaKNELGIYLCNLTVADLLYIFSLPFWLQYVLQHDNWTYSELLCKICGILLYENI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGgpaLYFRDTVEF----NNHTLCYNNFQKHDPD 197
Cdd:cd15367   85 YISIGFLCCISVDRYLAVVHPFRFHAFRTMKAATLVSTVIWLKELMTC---VFFFLHGEIskdkENHSVCFEHYPIKAWE 161
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 387763613 198 ltlirhHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHF---WTILVVVVAFVVCWTPYHLF----SIWE 269
Cdd:cd15367  162 ------HNINYYRFYAGFLFPIFLLSFSYCRILRAVRKSHGTQKSQKIqikRLVLSTVVIFLVCFGPYHILllvrSVFE 234
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
39-316 1.06e-22

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 95.79  E-value: 1.06e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGN--AIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFT 116
Cdd:cd15170    1 WLVLAVYIITFLIGLPANllAFYTFIRKVRRKPTPIDILLLNLTVSDLIFLLFLPFKMAEAASGMIWPLPYFLCPLSSFI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 117 AQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASL---IGGPALYFRDTVEFNNHTL--CYNNF 191
Cdd:cd15170   81 FFSTIYISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLAFShcsIVYIVEYHIDSENTSVTNNsrCYDNF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 192 QKHDPDLTL-IRHHVltwvkFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTI---LVVVVAFVVCWTPYHLfsi 267
Cdd:cd15170  161 TPEQLKILLpVRLEL-----FLVLFCIPFLITCFCYINFIRILSSLPHISRQRKQRAIglaVATLLNFIVCFAPYNI--- 232
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 387763613 268 weltihhnsySHHV--MQAGIP--------LSTglafLNSCLNPILYVLISKKFQARFR 316
Cdd:cd15170  233 ----------SHVVgfIQRKSPewrmyallLST----LNACLDPIIFYFSSSAVRRAFK 277
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
44-312 1.10e-22

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 96.10  E-value: 1.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIWFTGFKWKKTVTTL--WFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15925    6 AYGLVCAIGLLGNLAVMYLLRNCARRAPPPIdvFVFNLALADFGFALTLPFWAVESALDFHWPFGGAMCKMVLTATVLNV 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKhdpDLTLI 201
Cdd:cd15925   86 YASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGVELCLLKFPS---NYWLG 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLtwvKFIIGYLFPLLTMSICYLCLI-----FKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHH-- 274
Cdd:cd15925  163 AYHLQ---RVVVAFVVPLGVITTSYLLLLsflqqHKVNQNNRQRQSVIARSVRLVVASFFLCWFPNHVVTFWGVLVKFra 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 387763613 275 ---NSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15925  240 vpwNSTFYFIHTYVFPVTTCLAHSNSCLNPVLYCLMRREFR 280
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
51-315 1.10e-22

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 96.03  E-value: 1.10e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  51 LGIPGNAIVIWF----TGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVF 126
Cdd:cd15338   13 LGIIGNSIVIYTivkkSKFRCQQTVPDIFIFNLSIVDLLFLLGMPFLIHQLLGNGVWHFGETMCTLITALDTNSQITSTY 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 127 FLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTL-CYNNFQKHDPDLtlirhHV 205
Cdd:cd15338   93 ILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLMPLPDGSVgCALLLPNPETDT-----YW 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 206 LTWVKFIIGYLFPLLTMSICYLCLIFKV-------KKRSILISSRHFW-TILVVVVAFVVCWTPYHLFSIWELTIHHNSY 277
Cdd:cd15338  168 FTLYQFFLAFALPLVVICVVYFKILQNMastvaplPQRSLRVRTKKVTrMAVAICLAFFICWAPFYILQLAHLSIDRPSL 247
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 387763613 278 SHHVMQAgipLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15338  248 AFLYAYN---VAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
43-315 1.51e-22

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 95.89  E-value: 1.51e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFT-GFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFH-WPFGIWLCKANSFTAQLN 120
Cdd:cd15392    5 LMYSTIFVLAVGGNGLVCYIVvSYPRMRTVTNYFIVNLALSDILMAVFCVPFSFIALLILQyWPFGEFMCPVVNYLQAVS 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVlsHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTL 200
Cdd:cd15392   85 VFVSAFTLVAISIDRYVAIMWPL--RPRMTKRQALLLIAVIWIFALATALPIAITSRLFEDSNASCGQYICTESWPSDTN 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRHHvlTWVKFIIGYLFPLLTMSICYLCLIFKV----------KKRSILIS---SRHFWTILVVVVAFVVCWTPYHLFSI 267
Cdd:cd15392  163 RYIY--SLVLMILQYFVPLAVLVFTYTRIGIVVwakrtpgeaeNNRDQRMAeskRKLVKMMITVVAIFALCWLPLNILNL 240
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 387763613 268 WELtIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15392  241 VGD-HDESIYSWPYIPYLWLAAHWLAMSHCCYNPFIYCWMNAKFRNGF 287
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
44-310 2.69e-22

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 94.86  E-value: 2.69e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFA 123
Cdd:cd15371    6 VYIIVVVLGVPSNAIILWMLFFRLRSVCTAIFYANLAISDLLFCITLPFKIVYHLNGNNWVFGETMCRIITITFYGNMYC 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 124 SVFFLTVISLDHYIHLIHPVLsHRHRTLKN-SLIVIIFIWLLASLIGGPALYFRDTVEFN--NHTLCYNNFQKHDPDLTL 200
Cdd:cd15371   86 SILLLTCISINRYLAIVHPFI-YRSLPKKTyAVLICALVWTIVFLYMLPFFILKQTYYLKelNITTCHDVLPECEQNSNF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRHHVLTWVKFiiGYLFPLLTMSICYLCLIFKVKKrsilISSRHFWTI---LVVVVAFVVCWTPYHLFsiweLTIHHNSY 277
Cdd:cd15371  165 QFYYFISMAVF--GFLIPLVITIFCYISIIRTLNA----YEHKWFWYVkitALVLIIFTICFAPSNVI----LIIHHFNY 234
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 387763613 278 SHH---VMQAGIPLSTGLAFLNSCLNPILYVLISKK 310
Cdd:cd15371  235 YYFnndNLYSIYLIALCLGSLNSCLDPFLYFLMSKW 270
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
43-312 6.59e-22

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 93.74  E-value: 6.59e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMnfHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15186    5 IFYSLVFAFGLVGNLLVVLaLTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHYLIN--EWGLHNAMCKLTTAFFFIGF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFrdTVEFNNHtlCYNNFqkhdPDLTLI 201
Cdd:cd15186   83 FGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMF--TKMKENE--CLGDY----PEVLQE 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWVKF-IIGYLFPLLTMSICYLCLI---FKVKKRSiliSSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSY 277
Cdd:cd15186  155 IWPVLRNVELnFLGFLLPLLIMSYCYFRIIqtlFSCKNHK---KARAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDFF 231
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 387763613 278 SHHVMQA----GIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15186  232 PSCDMKKdlrlALSVTETIAFSHCCLNPLIYAFAGEKFR 270
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
43-315 1.21e-21

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 93.55  E-value: 1.21e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGN---AIVIWFTgfKWKKTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNFHWPFGIWLCKANSFTAQ 118
Cdd:cd15134    5 IIYGIIFVTGVVGNlctCIVIARN--RSMHTATNYYLFSLAVSDLLLLILgLPFELYTIWQQYPWVFGEVFCKLRAFLSE 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGP-ALYFRdtVEFNNHTLCYNNFQKHDPD 197
Cdd:cd15134   83 MSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPfAIQTR--IVYLEYPPTSGEALEESAF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 LTLIRHH----VLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSIL-----------ISSRHFWTILVVVVAFV----VC 258
Cdd:cd15134  161 CAMLNEIppitPVFQLSTFLFFIIPMIAIIVLYVLIGLQLRRSTLLrrgqrsvsggrRSSQSRRTVLRMLVAVVvaffIC 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 259 WTPYHLFSIweLTIHHNSYSHH---VMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15134  241 WAPFHAQRL--LTVYAKNMTPPylfINRILFYISGVLYYVSSTVNPILYNVMSAKYRQAF 298
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
40-315 1.26e-21

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 92.91  E-value: 1.26e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIWFTGFKW-KKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQ 118
Cdd:cd14988    2 VLFILYLVIFVVGLVENVLVIWVNWHRWgSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDYTWLWGSFLCKFTHYFYF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFnNHTLCY--NNFQKHDP 196
Cdd:cd14988   82 ANMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLPEVVHMQLLDG-VEPMCLflAPFETYDE 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 DLTLIrhhvlTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLfSIWELTIHHNS 276
Cdd:cd14988  161 WALAV-----SLLTLIIGFLIPFSIIAVFNVLTARYIRTAGRPESRRHCLLIYAYILVFVVCWLPYHV-TLLLLTLHGSH 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 387763613 277 YSHHVMQAGI-----PLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd14988  235 ISLHCNLVHFlyffyDVIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
43-315 2.78e-21

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 91.76  E-value: 2.78e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfhWPFGIWLCKANSFTAQLNM 121
Cdd:cd15173    5 CMYSVMFVTGLVGNSLVIVIYIFYEKlRTLTDIFLVNLAVADLLFLCTLPFWAYSAAHE--WIFGTVMCKITNGLYTINL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSL--IVIIFIWLLASLIGGPALYFRDTVEFNNHtlcyNNFQKHDPDLT 199
Cdd:cd15173   83 YSSMLILTCITVDRFIVIVQATKAHNCHAKKMRWgkVVCTLVWVISLLLSLPQFIYSEVRNLSSK----ICSMVYPPDAI 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 LIrhhVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYSH 279
Cdd:cd15173  159 EV---VVNIIQMTVGFFLPLLAMIICYSVIIKTLLHAKGFQKHKSLKIIFVVVAVFILTQLPYNIMKLIRTLHIENTDST 235
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 387763613 280 HVMQAgIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15173  236 NFKYA-ILITEAIAYLHACLNPILYAFVGVKFRKNF 270
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
43-313 4.20e-21

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 91.38  E-value: 4.20e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKW-KKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15365    5 FVYIFVIVISIPSNCISLYVSCLQIrKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDNWTLSGFVCIFSAFLLYTNF 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTV-EFNNHTLCYNNF--QKHDPDL 198
Cdd:cd15365   85 YTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFNAVILTWEDSFhESSSHTLCYDKFplEDWQARL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 TLIRhhvltwvkFIIGYLFPLLTMSICYLCLIFKVKKRSILIS---SRHFWTILVVVVAFVVCWTPYH-LFSIWELTIHH 274
Cdd:cd15365  165 NLFR--------ICLGYLLPLLIILFCYWKIYQAVRSNQATEDqekKKIFKLLLLITVTFVICFTPYHvVLLIRSIVEPC 236
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 387763613 275 NSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQA 313
Cdd:cd15365  237 DCRNAKWLYTLYKITVALTSLNCIADPFLYCFVTESGRA 275
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
43-315 6.39e-21

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 91.14  E-value: 6.39e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGF-KWKKTVTTLWFLNLAIADFIFLLF-LPLyiSYVAMNFH-WPFGIWLCKANSFTAQL 119
Cdd:cd15207    5 VSYSLIFLLCVVGNVLVCLVVAKnPRMRTVTNYFILNLAVSDLLVGVFcMPF--TLVDNILTgWPFGDVMCKLSPLVQGV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 120 NMFASVFFLTVISLDHYIHLIHPvlsHRHR-TLKNSLIVIIFIWLLASLIGGP-ALYFRDTVEFNNHTLCYNNFQKHDPD 197
Cdd:cd15207   83 SVAASVFTLVAIAVDRYRAVVHP---TEPKlTNRQAFVIIVAIWVLALAIMIPqALVLEVKEYQFFRGQTVHICVEFWPS 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 LTLIRhhVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSIL------------ISSRHFWTI---LVVVVAFVVCWTPY 262
Cdd:cd15207  160 DEYRK--AYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKPVPgggsasreaqaaVSKKKVRVIkmlIVVVVLFALSWLPL 237
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 387763613 263 HLFSIWELTIHHNSYSHHVMQAGI-PLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15207  238 HTVTMLDDFGNLSPNQREVLYVYIyPIAHWLAYFNSCVNPIVYGYFNRNFRKGF 291
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
43-315 8.70e-21

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 90.93  E-value: 8.70e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15393    5 ILYGIISLVAVVGNFLVIWVVAKNRRmRTVTNIFIANLAVADIIIGLFSIPFQFQAALLQRWVLPRFMCPFCPFVQVLSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVlsHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEF----NNHTLCYNNFQKHDPD 197
Cdd:cd15393   85 NVSVFTLTVIAVDRYRAVIHPL--KARCSKKSAKIIILIIWILALLVALPVALALRVEELtdktNNGVKPFCLPVGPSDD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 LTLIRHHVLtwvkFIIGYLFPLLTMSICYLCLIFKVKKRS------------ILISSRHFWTILVVVVAF-VVCWTPYHL 264
Cdd:cd15393  163 WWKIYNLYL----VCVQYFVPLVIICYAYTRIAVKIWGTKapgnaqdvrddeILKNKKKVIKMLIIVVALfALCWLPLQT 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 387763613 265 FSI-WELTIHHNSYSHhvmqagIPL----STGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15393  239 YNLlNEIKPEINKYKY------INIiwfcSHWLAMSNSCYNPFIYGLYNEKFKREF 288
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
43-312 1.46e-20

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 90.24  E-value: 1.46e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFL-NLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15370    5 IVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMaNLALADLLFVIWFPLKIAYHINGNNWIYGEALCKVLIGFFYGNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPvLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNH--TLCYNNFQkhdPDLT 199
Cdd:cd15370   85 YCSILFMTCLSVQRYWVIVNP-MSHSRKKANIAIGISLAIWLLILLVTIPLYLVKQTVFIPALdiTTCHDVLP---EQLL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 LIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISS-----RHFWTILVVVVAFVVCWTPYHLFSIWELTIHH 274
Cdd:cd15370  161 VGDMFNYFLSLAIGVFLFPAFLTAVAYVLMIRALKSSINDESIekkrkRAIKLIVTVLVMYLICFTPSNLLLVVHYFLLK 240
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 387763613 275 NSYSHHVMQAGIpLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15370  241 NQGQSSVYAFYI-TALCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
43-315 1.58e-20

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 89.99  E-value: 1.58e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFT-GFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd16003    5 LAYGFVVAVAVFGNLIVIWIIlAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVlsHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKhDPDLTLI 201
Cdd:cd16003   85 FASIYSMTAIAVDRYMAIIDPL--KPRLSATATKVVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVAWPG-GPDQHFT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLtwvkFIIGYLFPLLTMSICYLCLIFKV-----------KKRSILISSRHFWTILVVVVAFV-VCWTPYHLFSIWE 269
Cdd:cd16003  162 YHIIV----IVLVYCLPLLVMGITYTIVGITLwggeipgdtsdKYHEQLRAKRKVVKMMIIVVLTFaICWLPYHIYFIVT 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 387763613 270 LTIHHNSYSHHVMQAGIPlSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd16003  238 GLYQQLNRWKYIQQVYLA-SFWLAMSSTMYNPIIYCCLNKRFRAGF 282
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
43-315 2.40e-20

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 89.47  E-value: 2.40e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKKTVT-TLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15199    5 SLLILEFGLGLPGNAIALWTFIFRLKVWKPyAVYLLNLVLADVLLLICLPFKAYFYLNGNRWSLGGGTCKALLFMLSLSR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYfrdTVEFNNHTLCYNNFQKHDPDLTLI 201
Cdd:cd15199   85 GVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVGLTIPTLL---ASQPKNFTECNSFSPKDDEDFSDT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWVKFIIgylfPLLTMSICYLCLIFKVKKRSILISS-----RHFWTILVVVVAFVVCWTPYHLFSIWeLTIHHNS 276
Cdd:cd15199  162 WQEAVFFLQFLL----PFGLIVFCTVRIIRRLKKRLRDVGKqpklqRAMALVTSVVVVFGFCFLPCFLARVL-MLIFQNK 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 387763613 277 YSHHVMQAGIPLSTG---LAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15199  237 ESCNALNIAVHTYDVtmcLTYLNSVLDPIVYCFSSPTFRSSY 278
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
44-233 2.46e-20

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 89.55  E-value: 2.46e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVI---WFTgfKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15379    6 VYSVVFLLGLPLNAVVIgqiWAT--RQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKDYWPFGDFTCRLVRFQFYTN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLS-HRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNnfqKHDPDLT 199
Cdd:cd15379   84 LHGSILFLTCISVQRYLGICHPLASwHKKKGKKLTWLVCGAVWLVVIAQCLPTFVFASTGTQRNRTVCYD---LSPPARS 160
                        170       180       190
                 ....*....|....*....|....*....|....
gi 387763613 200 lIRHHVLTWVKFIIGYLFPLLTMSICYlCLIFKV 233
Cdd:cd15379  161 -TAYFPYGITLTRTGFLLPFAARLACY-CSMATI 192
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
47-315 3.67e-20

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 88.95  E-value: 3.67e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  47 LAFVLGIPGNAIVIWFTGF---KWKKTvtTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFA 123
Cdd:cd15201    9 LEFVLGLLGNGLALWIFCFhlkSWKSS--TVYLFNLAVADFLLIICLPFRTDYYLRGKHWKFGDIPCRIVLFMLAMNRAG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 124 SVFFLTVISLDHYIHLIHPvlSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDtvefnNHTLCYNNFQKHDPDLTLIRH 203
Cdd:cd15201   87 SIFFLTAVAVDRYFRVVHP--HHRINSISVRKAAIIACGLWLLTIAMTVYLLTK-----KHLFPRGNATQCESFNICTGT 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 204 -HVLTWVK--FIIGYLFPLLTMSICYLCLIFKVKKRSILISS---RHFWTILVVVVAFVVCWTPYHL--FSIWELTIHHN 275
Cdd:cd15201  160 dSSSNWHEamFLLEFFLPLAIILYCSVRIIWQLRGRQLDRHAkikRAVQFIMVVAIVFIICFLPSNVtrIAIWILKHTSN 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 387763613 276 SYSHHVMQAGIPLSTGLAF--LNSCLNPILYVLISKKFQARF 315
Cdd:cd15201  240 EDCQYYRSVDLAFYITISFtyFNSMLDPVVYYFSSPSFKNFY 281
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
43-323 4.20e-20

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 88.46  E-value: 4.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIwlckANSFTAQLNMF 122
Cdd:cd14973    5 SLTVLLSLCGLVGNGLVLWLLGFRIKRNPFSVYILNLAAADFLFLSCQAIQSLEDLLGGSLPGFA----LCRLLATLMFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ---ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFrdtvefnnhtlCYNNFQKHDPDLT 199
Cdd:cd14973   81 sytVGLSLLAAISTERCLSVLFPIWYRCHRPKHLSAVVCALLWALSLLLSVLESYF-----------CGFLFWKFNESAC 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 LIRhhvltWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILI-SSRHFWTILVVVVAFVVCWTPYHLfsIWELTI-HHNSY 277
Cdd:cd14973  150 RTF-----NFLSALLFLLLFLVMCVSSLTLLIRVQCSSQRRpPTRLYVVILLTVLVFLLCGLPLGI--YWFLLLwFSNYL 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 387763613 278 SHHVMqagiPLSTGLAFLNSCLNPILYVLISKKFQARFRSSVAEIL 323
Cdd:cd14973  223 FHTFH----PISDLLSCVNSSANPIIYFFVGSLRGRRLREPLRVVL 264
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
43-315 4.33e-20

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 88.77  E-value: 4.33e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFT-GFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd16002    5 VAYSVIVVVSVVGNIIVMWIIlAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKFHNFFPIAAV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTlkNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLI 201
Cdd:cd16002   85 FASIYSMTAIALDRYMAIIHPLQPRLSAT--ATKVVICVIWVLAFLLAFPQGYYSDTEEMPGRVVCYVEWPEHEERKYET 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTwvkFIIGYLFPLLTMSICYLCLIFKVKKRSI-----------LISSRHFWTILVVVV-AFVVCWTPYHLFSIWE 269
Cdd:cd16002  163 VYHVCV---TVLIYFLPLLVIGCAYTVVGITLWASEIpgdssdryheqVSAKRKVVKMMIVVVcTFAICWLPYHIYFLLQ 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 387763613 270 lTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd16002  240 -YFHPELYEQKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRVGF 284
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
44-315 4.35e-20

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 88.95  E-value: 4.35e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAI-VIWFTGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd14979    6 IYVAIFVVGIVGNLLtCIVIARHKSLRTTTNYYLFSLAVSDLLILLVgLPVELYNFWWQYPWAFGDGGCKLYYFLFEACT 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNnhtLCYNNFQKHDPDLTLI 201
Cdd:cd14979   86 YATVLTIVALSVERYVAICHPLKAKTLVTKRRVKRFILAIWLVSILCAIPILFLMGIQYLN---GPLPGPVPDSAVCTLV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWVKF----IIGYLFPLLTMSICYLCLIFKVKKRSI----------------LISSRHFWTILVVVVAFV---VC 258
Cdd:cd14979  163 VDRSTFKYVFqvstFIFFVLPMFVISILYFRIGVKLRSMRNikkgtraqgtrnvelsLSQQARRQVVKMLGAVVIaffVC 242
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 387763613 259 WTPYHL-------FSIWELTIhhnsysHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd14979  243 WLPFHAqrlmfsyASKEDTFL------FDFYQYLYPISGILFYLSSAINPILYNLMSSRFRVAF 300
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
43-313 7.38e-20

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 88.27  E-value: 7.38e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKKTVT-TLWFLNLAIADFIFLLFLPLYISYVAMNfHWPFGIWLCKANSFTAQLNM 121
Cdd:cd14999    4 TVLSLMCVVGVAGNVYTLVVMCLSMRPRASmYVYILNLALADLLYLLTIPFYVSTYFLK-KWYFGDVGCRLLFSLDFLTM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIfIWLLASLIGGPALYF-----RDTVEFNNHTLCYnnfqkhdP 196
Cdd:cd14999   83 HASIFTLTVMSTERYLAVVKPLDTVKRSKSYRKLLAGV-IWLLSLLLTLPMAIMirlvtVEDKSGGSKRICL-------P 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 DLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFK---------VKKRSILISSRHFWTILVVVVAFVVCWTPyhlFSI 267
Cdd:cd14999  155 TWSEESYKVYLTLLFSTSIVIPGLVIGYLYIRLARKywlsqaaasNSSRKRLPKQKVLKMIFTIVLVFWACFLP---FWI 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 387763613 268 WELTIHHN---SYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQA 313
Cdd:cd14999  232 WQLLYLYSpslSLSPRTTTYVNYLLTCLTYSNSCINPFLYTLLTKNYKE 280
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
42-315 2.86e-19

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 86.36  E-value: 2.86e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfHWPFGIWLCKANSFTAQLN 120
Cdd:cd15154    4 LVGYSLLFPVGLLLNAVALWvFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANH-YWPFGNFLCQFSGSIFQMN 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPvLSHRH-RTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNH----TLCYNNFQKHD 195
Cdd:cd15154   83 MYGSCLFLMCINVDRYLAIVHP-LRFRHlRRPKVARLLCLAVWALILGGSVPAAIVHSSSDCLLHgekvYRCFESFSDND 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 196 PDLTLirhhVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTI---LVVVVAFVVCWTPYH-LFSIWELT 271
Cdd:cd15154  162 WKGLL----PLVVLAEILGFLLPLAAVLYCSCRIFVELCRTQEPQQGRRRKTVrllLVNLVIFLICFVPYNtTLAVYGLL 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 387763613 272 ----IHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15154  238 ranlVEDTWNIKDTLRKVLSVTVLLASTNCALDPLVYYFSTEGFRNTL 285
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
43-315 3.11e-19

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 86.36  E-value: 3.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15368    5 VVYSLVALISIPGNLFSLWLLCFHTKpKTPSIIFMINLSLTDLMLACFLPFQIVYHIQRNHWIFGKPLCNVVTVLFYANM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDT--VEFNNHTLCYNNFQKHdpdlt 199
Cdd:cd15368   85 YSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERTDLTyyVKELNITTCFDVLKWT----- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 lIRHHVLTWVKFIIG-----YLFPLLTMSICYLCLIFKVKKRSILISS----RHFWTILVVVVAFVVCWTPYHLFsiweL 270
Cdd:cd15368  160 -MLPNIAAWAAFLFTlfillFLIPFIITVYCYVLIILKLVQTSERYGReqkrRAIYLALIVLLVFITCFAPNNFI----L 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 387763613 271 TIHHNS--YSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15368  235 LAHMVSrlFYGKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
42-308 2.07e-18

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 84.06  E-value: 2.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15364    4 VVVYSVVFALGFPANCLTLWLTLLQVRrKNVLAVYLFSLSLCELLYLGTLPLWTIYVSNNHKWPWGSLACKITGYIFFCN 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTlCYNNFQKHDpdltl 200
Cdd:cd15364   84 IYISILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGLVHSPVFIMREGQTEGSHT-CFETLQMDT----- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 iRHHVLTWVKFIIGYLFPlLTMSICYLCLIFKVKKRSILISSRH----FWTILVVVVAFVVCWTPYHL-FSIWELTIHHN 275
Cdd:cd15364  158 -QVAGFYYARFCIGFAIP-LAILIFTNYRIFRSIQTSTSLTPHQkakvKYLAIAVIVIFLICFAPYHLvLLVRAIAFSLY 235
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 387763613 276 -----SYSHHVMQAGIpLSTGLAFLNSCLNPILYVLIS 308
Cdd:cd15364  236 pngmcGFEERIYTPSV-IFLCLSTVNSVADPIIYVLVS 272
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
47-315 4.32e-18

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 82.89  E-value: 4.32e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  47 LAFVLGIPGNAIVIWFTGFK---WKKTvtTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFA 123
Cdd:cd15200    9 IEFVLGLVGNGIALFIFCFHrrpWKSN--TMYLLSLVVADFFLIINLPFRIDYYLRNEVWRFGATACQVNLFMLSMNRTA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 124 SVFFLTVISLDHYIHLIHPvlshrHRTLKNSLI-----VIIFIWLLASLIGGPaLYFRDTVEFNNHTLCYNnfQKHDPDL 198
Cdd:cd15200   87 SIVFLTAIALNRYLKVVHP-----HHQLSKASVgcaakVAAGLWILILLLNIH-LLLLDHVQSNSTCLSYD--HGTDPSA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 TLIRHHVLtwvkFIIGYLFPLLTMSICYLCLIFKVKKRSILISS---RHFWTILVVVVAFVVCWTPYHLFSIWELTIHHN 275
Cdd:cd15200  159 SDRWHRIL----FFLEFFLPLGIILFCIFSIILTLKQRKLAKQAgpqRAVKVLAVIVLVYTVCFLPSILFALASLVAFKV 234
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 387763613 276 SYSHHVMQAGIPLSTGLAF--LNSCLNPILYVLISKKFQARF 315
Cdd:cd15200  235 SQCRSLDLCTQLFHGSLAFtyLNSALDPVLYCFSSPSFLNQS 276
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
43-305 5.45e-18

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 83.09  E-value: 5.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIwFTGFKWKK--TVTTLWFLNLAIADFIFLLF-LPLYISY-VAMNFHWPFGIWLCKANSFTAQ 118
Cdd:cd15204    5 VVYVLIMLVCGVGNLLLI-AVLARYKKlrTLTNLLIANLALSDFLVAVFcLPFEMDYyVVRQRSWTHGDVLCAVVNYLRT 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPvlSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNH--TLCYNNFQKHDp 196
Cdd:cd15204   84 VSLYVSTNALLVIAIDRYLVIVHP--LKPRMKRRTACVVIALVWVVSLLLAIPSAVYSKTTPYANQgkIFCGQIWPVDQ- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 dltLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRS-----------ILISSRHFWTILVVVVAF-VVCWTPYHL 264
Cdd:cd15204  161 ---QAYYKAYYLFLFVLEFVLPVLIMTLCYLRIVRKVWFRRvpgqqteqirrRLRRRRRKVRLLVVILTAfVLCWAPYYG 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 387763613 265 FSIWE-------LTIHHNSYSHHVMQAgiplstgLAFLNSCLNPILYV 305
Cdd:cd15204  238 YAIVRdffptllSKEKLNTTIFYIVEA-------LAMSNSMINTVVYV 278
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
40-315 7.16e-18

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 82.74  E-value: 7.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLgIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNfHWPFGIWLCKANSFTA 117
Cdd:cd15048    3 LAVLISVLILVT-VIGNLLVILaFIKDKKLRTVSNFFLLNLAVADFLVGLVsMPFYIPYTLTG-KWPFGKVFCKAWLVVD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 118 QLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYF------RDTVEFNNhtlCYNNF 191
Cdd:cd15048   81 YTLCTASALTIVLISLDRYLSVTKAVKYRAKQTKRRTVLLMALVWILAFLLYGPAIIGwdlwtgYSIVPTGD---CEVEF 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 192 QkhdpdltliRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVV-------------- 257
Cdd:cd15048  158 F---------DHFYFTFITSVLEFFIPFISVSFFNLLIYLNIRKRSRRRPLRSVPILPASQNPSRArsqreqvklrrdrk 228
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 387763613 258 --------------CWTPYHLFSIWeLTIHHNSYSHHVMqagIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15048  229 aakslailvlvfliCWAPYTILTII-RSFCSGSCVDSYL---YEFTFWLLWTNSAINPFLYAACHPRFRKAF 296
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
40-315 7.68e-18

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 82.45  E-value: 7.68e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYISYvAMNFHWPFGIWLCKANSFTA 117
Cdd:cd15195    2 VRVLVTWVLFVISAAGNLTVLIqLFRRRRAKSHIQILIMHLALADLMVTFFnMPMDAVW-NYTVEWLAGDLMCRVMMFLK 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 118 QLNMFASVFFLTVISLDHYIHLIHPVLSHRHRtlKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYN-----NFQ 192
Cdd:cd15195   81 QFGMYLSSFMLVVIALDRVFAILSPLSANQAR--KRVKIMLTVAWVLSALCSIPQSFIFSVLRKMPEQPGFHqcvdfGSA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 193 KHDPDLTLirHHVLTwvkFIIGYLFPLLTMSICYLCLIFKV--------------------------KKRSILISSrhfw 246
Cdd:cd15195  159 PTKKQERL--YYFFT---MILSFVIPLIITVTCYLLILFEIskmakrardtpisnrrrsrtnsleraRMRTLRMTA---- 229
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 387763613 247 tilVVVVAFVVCWTPYHLFSIW-----ELTIHHNSYSHHVMQAgiplstgLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15195  230 ---LIVLTFIVCWGPYYVLGLWywfdkESIKNLPPALSHIMFL-------LGYLNPCLHPIIYGVFMKEIRNWI 293
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
43-315 8.01e-18

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 82.55  E-value: 8.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFT-GFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15202    5 VAYSFIIVFSLFGNVLVCWIIfKNQRMRTVTNYFIVNLAVADIMITLFNTPFTFVRAVNNTWIFGLFMCHFSNFAQYCSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPvLSHRHRTLKnSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHD-PDLTL 200
Cdd:cd15202   85 HVSAYTLTAIAVDRYQAIMHP-LKPRISKTK-AKFIIAVIWTLALAFALPHAICSKLETFKYSEDIVRSLCLEDwPERAD 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSI---LISSRHFW----------TILVVVVAFVVCWTPYHLFSI 267
Cdd:cd15202  163 LFWKYYDLALFILQYFLPLLVISFAYARVGIKLWASNMpgdATTERYFAlrrkkkkvikMLMVVVVLFALCWLPFNIYVL 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 387763613 268 weLTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15202  243 --LLSSKPDYLIKTINAVYFAFHWLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
43-315 8.97e-18

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 82.20  E-value: 8.97e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFT-GFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd16004    5 IAYSLIVLVAVTGNATVIWIIlAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTlkNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLI 201
Cdd:cd16004   85 FVSIYSMTAIAADRYMAIIHPFKPRLSAG--STKVVIAGIWLVALALAFPQCFYSTVTMDQGRTKCIVAWPGDSGGKHQL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVltwVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRH-------------FWTILVVVVAFVVCWTPYHLFSIW 268
Cdd:cd16004  163 TYHL---AVIVLIYLLPLAVMFVTYSIIGITLWRSAVPGHQAHgayhrqlqakkkfVKTMVVVVVTFAICWLPYHLYFIL 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 387763613 269 ElTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd16004  240 G-SFNEDIYCQKYIQQVYLAIFWLAMSSTMYNPIIYCCLNQRFRSGF 285
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
40-313 1.15e-17

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 82.15  E-value: 1.15e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLaFVLGIPGNAIVIWFTG-FKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQ 118
Cdd:cd15928    3 VTAVCSVL-MLVGASGNLLTVLVIGrSRDMRTTTNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALyFRDTVEFNNHTLCYNNFQKHDPDL 198
Cdd:cd15928   82 TCTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPAL-VLVGVEHIQGQQTPRGFECTVVNV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 TLIRHHVLTWVKFIIgYLFPLLTMSICYLCLIFKV-----KKRSILISSR---HFWTI---LVVVVAFVVCWTPYHL-FS 266
Cdd:cd15928  161 SSGLLSVMLWVSTSF-FFVPMVCLSLLYGLIGRALwdrrqRSRTAGASRRdnnHRQTVrmlAVIVLAFVLCWLPFHVgRV 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 387763613 267 IWELTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQA 313
Cdd:cd15928  240 IFNHSRASTKHLHYVSQYFNLVSFVLFYLSAAINPILYNLMSKRYRY 286
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
43-314 1.37e-17

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 81.69  E-value: 1.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVaMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15152    5 VTYTVILIPGLIGNVLALWvFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYY-LNKSWPFGKFLCMFCFYLKYVNM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFiWLLASLIGGPALYFRDTvEFNNHTLCYNNFQKHDPDLTLi 201
Cdd:cd15152   84 YASIYFLVCISVRRCLYLIYPFRYNDCKRKCDVYISIAG-WLVVCVGCLPFPLLRQS-QDTNPTCCFADLPLRNVGLTT- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 rHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISS-----RHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNS 276
Cdd:cd15152  161 -SVIMLTIAELTGFVTPLLIVLYCSWKTVMSLREKTPVLQDlgekkKALKMILTCAVVFLICFAPYHISFPLDFLVKSNK 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 387763613 277 YSHHVMQAGI----PLSTGLAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd15152  240 IKSCTARKVIlifhPVALCLASLNSCLDPVIYYFTTDEFKRR 281
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
44-313 1.89e-17

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 81.32  E-value: 1.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15394    6 LYSLVVLVGVVGNYLLIYVICRTKKmHNVTNFLIGNLAFSDMLMCATcVPLTLAYAFEPRGWVFGRFMCYFVFLMQPVTV 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVlsHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNH--TLCyNNFQKHDPDLT 199
Cdd:cd15394   86 YVSVFTLTAIAVDRYYVTVYPL--RRRISRRTCAYIVAAIWLLSCGLALPAAAHTYYVEFKGLdfSIC-EEFWFGQEKQR 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 LIrhhvLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILIS-------------SRHFWTILVVVVAFVVCWTPYHLFS 266
Cdd:cd15394  163 LA----YACSTLLITYVLPLLAISLSYLRISVKLRNRVVPGSmtqsqaewdrarrRKTFRLLVVVVVAFAICWLPLHIFN 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 387763613 267 -IWELTIHH-NSYSHHVMQAgipLSTGLAFLNSCLNPILYVLISKKFQA 313
Cdd:cd15394  239 vIRDIDIDLiDKQYFNLIQL---LCHWLAMSSACYNPFLYAWLHDSFRG 284
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
44-307 2.34e-17

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 80.99  E-value: 2.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIWFTGFK-WKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15366    6 LYIIVIVLGLPTNCLALWAAYLQvRQRNELGVYLLNLSVSDLLYIATLPLWIDYFLHRDNWIHGPESCKLFGFIFYTNIY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFN-NHTLCYNNFQKHDpdltli 201
Cdd:cd15366   86 ISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGANSAPLFHDELFRDRyNHTFCFEKYPMED------ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 rhhvltWV------KFIIGYLFPLLTMSICYLCLIFKVKKrSILISSRHFWTI----LVVVVAFVVCWTPYHLFSI---- 267
Cdd:cd15366  160 ------WVawmnlyRVFVGFLFPWVLMLFSYRGILRAVRG-NVSTEQQEKAKIkrlaLSLIAIVLLCFAPYHVLLLsrsv 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 387763613 268 ------WELTIHHNSYS-HHVmqagiplSTGLAFLNSCLNPILYVLI 307
Cdd:cd15366  233 vylgkpCDCGFEERVFTaYHV-------SLALTSLNCVADPILYCLV 272
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
14-317 2.74e-17

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 81.49  E-value: 2.74e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  14 NYSYdldYYSLESDLEekVQLGVVHWVSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPlY 93
Cdd:PHA02834   9 NYSY---YFEEECDFE--MVNSDVNYFVIVFYILLFIFGLIGNVLVIAVLIVKRFMFVVDVYLFNIAMSDLMLVFSFP-F 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  94 ISYVAMNfHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVlSHRHRTLKNSLIVIIFIWLLASLIGGPA- 172
Cdd:PHA02834  83 IIHNDLN-EWIFGEFMCKLVLGVYFVGFFSNMFFVTLISIDRYILVVNAT-KIKNKSISLSVLLSVAAWVCSVILSMPAm 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 173 -LYFRDTVEFNNHTLcYNNFQKHDPDLTLIRHHVltwvkFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVV 251
Cdd:PHA02834 161 vLYYVDNTDNLKQCI-FNDYHENFSWSAFFNFEI-----NIFGIVIPLIILIYCYSKILYTLKNCKNKNKTRSIKIILTV 234
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 387763613 252 VVAFVVCWTPYH-------LFSIWELTIhhNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARFRS 317
Cdd:PHA02834 235 VTFTVVFWVPFNivlfinsLQSVGLIDI--GCYHFKKIVYSIDIAELISFVHCCVNPIIYAFVGKNFKKVFKN 305
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
43-308 3.62e-17

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 80.51  E-value: 3.62e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15148    5 VFYSLIFLFGLVGNLLALWvFLFIHRKRNSVRIFLINVAIADLLLIICLPFRILYHVNNNQWTLGPLLCKVVGNLFYMNM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLAslIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLI 201
Cdd:cd15148   85 YISIILLGFISLDRYLKINRSSRRQKFLTRKWSIVACGVLWAVA--LVGFVPMIVLTEKNEESTKCFQYKDRKNAKGKAI 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWVKFIIgylFPLLTMSICYLC--LIFKVKKRSILISSRHF----WTILVVVVAFVVCWTPYHLFSIWELTIH-- 273
Cdd:cd15148  163 FNFLIVAMFWLV---FLLLILSYGKIAkkLLRISRDKPDFPNAAKYnrtaRKSFFVLFIFTVCFVPYHAFRIFYITSQlq 239
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 387763613 274 -HNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLIS 308
Cdd:cd15148  240 nNSCYWKEILHKTNEIMLLLSAFNSCLDPVMYFLLS 275
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
39-315 3.69e-17

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 80.54  E-value: 3.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYIsYVAMNFHWPFGIWLCKANSFT 116
Cdd:cd14977    1 YVIMSLSLVIFAVGIIGNLMVLCiVCTNYYMRSVPNILIASLALGDLLLLLLcVPLNA-YNLLTKDWLFGDVMCKLVPFI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 117 AQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDP 196
Cdd:cd14977   80 QVTSLGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTVARESSLDNSSLTVCIMKP 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 DLTLIRHH--VLTWVKFIIGYLFPLLTMSICYlCLIFKVK-----------KRSILISSRHFWTILVVVVAFVVCWTPYH 263
Cdd:cd14977  160 STPFAETYpkARSWWLFGCYFCLPLAFTAVCY-LLMARTLiraakeytrgtKKHMKQRRQLAKTVLCLVLVFAFCWLPEH 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 387763613 264 LFSIWELTIH--HNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd14977  239 ISNILRATLYneVLIDTRSTLDILDLIGQFLSFFNSCVNPIALYLLSEPFRRAF 292
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
40-312 4.05e-17

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 80.00  E-value: 4.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIWFTGFKWKK-TVTTLWFLNLAIADFIFLLFLPLYISYvaMNFHWPFGIWlCKANSFTAQ 118
Cdd:cd15164    2 IQLIIYIPILFFGLLFNVLALWVFCCKMKKwTETRVYMINLAVADCCLLFSLPFVLYF--LKHSWPDDEL-CLVLQSIYF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLasLIGGpaLYFRDTVEFNNHTLCynnFQKhdpdl 198
Cdd:cd15164   79 INRYMSIYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLWVL--VIIS--VSLRLAWEEQEENFC---FGK----- 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 TLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRH------FWTILVVVVAFVVCWTPYHLFSIWELTI 272
Cdd:cd15164  147 TSTRPSKRTLIFSLLGFFIPLIILSFCSIQVIRSLKKKKKTNPHEEkliqkaIYIVSANLIVFIVCFLPLHIGLLVRFVM 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 387763613 273 HHNSYSHHVMQAG---IPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15164  227 ESNKASCSLIQNIrnfIYVASCLANANCCLDAICYYFVAKEFQ 269
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
39-315 4.61e-17

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 80.41  E-value: 4.61e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGN---AIVIWftGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNFHWPFGIWLCKANS 114
Cdd:cd14997    1 VLVSVVYGVIFVVGVLGNvlvGIVVW--KNKDMRTPTNIFLVNLSVADLLVLLVcMPVALVETWAREPWLLGEFMCKLVP 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 115 FTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVE--FNNHTLCYNNFQ 192
Cdd:cd14997   79 FVELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITEFKEedFNDGTPVAVCRT 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 193 KHDPDLTLIRHHVLTWVKFIIgylfPLLTMSICYLCLIFKVKKRSILISSRH--------------FWTILVVVVAFVVC 258
Cdd:cd14997  159 PADTFWKVAYILSTIVVFFVV----PLAILSGLYSVICRRLVGHPALESRRAdaanrhtlrsrrqvVYMLITVVVLFFVC 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 387763613 259 WTPYHLFSIWELtihhnsYSHHVMQAGIPLSTGL---------AFLNSCLNPILYVLISKKFQARF 315
Cdd:cd14997  235 LLPFRVVTLWII------FAPDEDLQALGLEGYLnllvfcrvmVYLNSALNPILYNLMSTKFRSAF 294
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
40-315 5.38e-17

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 80.21  E-value: 5.38e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIWF-TGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQ 118
Cdd:cd15205    2 AFVITYVLIFVLALFGNSLVIYVvTRKRAMRTATNIFICSLALSDLLITFFCIPFTLLQNISSNWLGGAFMCKMVPFVQS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFR------DTVEFNNHTLCYNNFQ 192
Cdd:cd15205   82 TAVVTSILTMTCIAVERHQGIVHPLKMKWQYTNRRAFTMLGLVWIVSVIVGSPMLFVQqlevkyDFLYEKRHVCCLERWY 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 193 KHdpdltlIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFK--VKKR----SILISSRHFWT-------------ILVVVV 253
Cdd:cd15205  162 SP------TQQKIYTTFILVILFLLPLTTMLFLYSRIGYElwIKKRvgdaSVLQTIHGIEMskisrkkkravkmMVTVVL 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 387763613 254 AFVVCWTPYHLFSIW-ELTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15205  236 LFAVCWAPFHVVHMMiEYSNLENKYDGVTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFKKNF 298
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
43-316 7.30e-17

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 79.31  E-value: 7.30e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIwFTGFKWK--KTVTTLWFLNLAIADFIF-LLFLPLYISYVAMNFHWPFGIWLCKANSFTAQL 119
Cdd:cd15053    5 LFLLLLPLLTVFGNVLVI-MSVFRERslQTATNYFIVSLAVADLLVaILVMPFAVYVEVNGGKWYLGPILCDIYIAMDVM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 120 NMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLC--YNnfqkhdPD 197
Cdd:cd15053   84 CSTASIFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDPEECrfYN------PD 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 LTLIRHhvltwvkfIIGYLFPLLTMSICYLClIFKVKKRsiliSSRHFWTILVVVVAFVVCWTPYHLFSIWE-LTIHHNS 276
Cdd:cd15053  158 FIIYSS--------ISSFYIPCIVMLLLYYR-IFRALRR----EKKATKTLAIVLGVFLFCWLPFFTLNILNaICPKLQN 224
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 387763613 277 YSHHVMQAGIPLSTGLAFLNSCLNPILYVLiskkFQARFR 316
Cdd:cd15053  225 QSCHVGPALFSLTTWLGYVNSFLNPIIYTI----FNIEFR 260
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
50-313 1.27e-16

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 78.90  E-value: 1.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  50 VLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLL---FLPLYISyvAMNFHWPFGIWLCKANSFTAQLNMFASV 125
Cdd:cd15337   12 ILGVIGNLLVIYlFSKTKSLRTPSNMFIINLAISDFGFSAvngFPLKTIS--SFNKKWIWGKVACELYGFAGGIFGFMSI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 126 FFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALY-FRDTVEFNNHTLC-YNNFQKHDPDLTLIrh 203
Cdd:cd15337   90 TTLAAISIDRYLVIAKPLEAMKKMTFKRAFIMIIIIWLWSLLWSIPPFFgWGRYVPEGFQTSCtFDYLSRDLNNRLFI-- 167
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 204 hvltWVKFIIGYLFPLLTMSICYLCLIFKV-------------------------KKRSILISSRHFWTILvvvvAFVVC 258
Cdd:cd15337  168 ----LGLFIFGFLCPLLIIIFCYVNIIRAVrnhekemtqtaksgmgkdtekndarKKAEIRIAKVAIILIS----LFLLS 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 387763613 259 WTPYH---LFSIWeltihhnSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQA 313
Cdd:cd15337  240 WTPYAvvaLLGQF-------GPAYWITPYVSELPVMFAKASAIYNPIIYALSHPKFRA 290
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
39-315 1.28e-16

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 79.36  E-value: 1.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIWFTgfkWK----KTVTTLWFLNLAIADFIFLLF-LPL-YISYVAMNfhWPFGIWLCKA 112
Cdd:cd15208    1 WVLIALYILVFIVGLVGNVLVCFAV---WRnhhmRTVTNYFIVNLSLADFLVIIIcLPAtLLVDVTET--WFFGQVLCKI 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 113 NSFTAQLNMFASVFFLTVISLDHYIHLIHPVLShrHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQ 192
Cdd:cd15208   76 IPYLQTVSVSVSVLTLSCIALDRWYAICHPLMF--KSTAKRARVSILIIWIVSLLIMIPQAIVMECSRVVPLANKTILLT 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 193 KHDP-DLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISS---RHFWT--------------------- 247
Cdd:cd15208  154 VCDErWSDSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLWCRQIPGTSsvvQRKWNkprksavaaeekqlrsrrkta 233
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 248 --ILVVVVAFVVCWTPYHLFSIWELTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15208  234 kmLIVVVIMFAICYLPVHLLNILRYVFGLFTVDRETIYAWFLFSHWLVYANSAINPIIYNFMSGKFREEF 303
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
46-311 3.47e-16

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 77.27  E-value: 3.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  46 CLAFVLGIPGNAIVIwfTGFKWKKTVTT---LWFLNLAIADFIFLLF--LPLYISYVAMNFHWPfgIWLCKANSFTAQLN 120
Cdd:cd15196    8 ATILVLALFGNSCVL--LVLYRRRRKLSrmhLFILHLSVADLLVALFnvLPQLIWDITYRFYGG--DLLCRLVKYLQVVG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTlKNSLIVIIFIWLLASLIGGPALY-FRDTVEFNNHTLCYNNFQkhdPDLT 199
Cdd:cd15196   84 MYASSYVLVATAIDRYIAICHPLSSHRWTS-RRVHLMVAIAWVLSLLLSIPQLFiFSYQEVGSGVYDCWATFE---PPWG 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 LIRHhvLTWVKFIIgYLFPLLTMSICYLCL---IFKVKKRSILISsrhfwtiLVVVVAFVVCWTPYHLFSIWELTIHHNS 276
Cdd:cd15196  160 LRAY--ITWFTVAV-FVVPLIILAFCYGRIcyvVWRAKIKTVKLT-------LVVVACYIVCWTPFFVVQMWAAWDPTAP 229
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 387763613 277 YSHHVMQagipLSTGLAFLNSCLNPILYVLISKKF 311
Cdd:cd15196  230 IEGPAFV----IIMLLASLNSCTNPWIYLAFSGNL 260
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
43-312 7.91e-16

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 76.71  E-value: 7.91e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTL--WFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQL 119
Cdd:cd15147    5 IVYSIIFVLGLIANCYVLWvFARLYPSKKLNEIkiFMVNLTIADLLFLITLPFWIVYYHNEGNWILPKFLCNVAGCLFFI 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 120 NMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDT----VEFNNHTLCYNNFQKHD 195
Cdd:cd15147   85 NTYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASASYFLFMDSTntvkIDSGNFTRCFEGYEKDN 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 196 PDLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVK-KRSILISSRHFWTILVVVVAFVVCWTPYHLFSI-WELTI- 272
Cdd:cd15147  165 SKPVLIIHFIIIGLFFLVFLLILVCNLVIARTLLSQPVQgQRNAGVKRRALWMVCTVLAVFVICFVPHHVVQGpWTLAVl 244
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 387763613 273 ----HHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15147  245 qqwrYWDCQFRQALNDAHQITLCLMSTNCVLDPVIYCFLTKKFR 288
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
40-315 1.35e-15

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 75.82  E-value: 1.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAfVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNfHWPFG-----IWLCKa 112
Cdd:cd15049    3 ICIATGSLS-LVTVGGNILVILsFRVNRQLRTVNNYFLLSLACADLIIGLVsMNLYTVYLVMG-YWPLGpllcdLWLAL- 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 113 nSFTAQLnmfASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYF------RDTVEFNNhtl 186
Cdd:cd15049   80 -DYVASN---ASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGwqyfvgERTVPDGQ--- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 187 CYNNFqkhdpdltlIRHHVLTWVKFIIGYLFPLLTMSICYlCLIFKVKKRsiliSSRHFWTILVVVVAFVVCWTPYHLFS 266
Cdd:cd15049  153 CYIQF---------LDDPAITFGTAIAAFYLPVLVMTILY-WRIYRETAR----ERKAARTLSAILLAFIITWTPYNILV 218
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 387763613 267 IWeltihhNSYSHHVMQAGI-PLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15049  219 LV------STFCAKCIPDTLwSFGYWLCYINSTINPFCYALCNKTFRKTF 262
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
43-314 2.11e-15

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 75.60  E-value: 2.11e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15969    5 VLYLIIFIGSILLNGLAVWIFFHIRNKTSFIFYLKNIVIADLLMTLTFPFKIIQDSGLGPWNFNFFLCRYTSVLFYASMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYF--RDTVEFNNHtlcynNFQKHDPDLTL 200
Cdd:cd15969   85 TSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLSLPNIILtnGQPTEDNIH-----DCSKLKSPLGV 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRHHVLTWVKFIIgYLFPLLTMSICYLCL---IFKVKKRSILISSR---HFWTILVVVVAFVVCWTPYHL----FSIWEL 270
Cdd:cd15969  160 KWHTAVSYINICI-FVAVLVILIVCYISIsryIYKSSKQFISSSSRtrkHNQSIRVVVAVFFVCFLPYHLcripFTFSQL 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 387763613 271 TIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd15969  239 DKILDCTIKTILYYCKEATLFLSACNVCLDPIIYFFMCRSFSQR 282
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
46-315 2.39e-15

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 75.48  E-value: 2.39e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  46 CLAFVLGIPGNAIVIW--FTGFKWKKTVTTLWFLNLAIAD-FIFLLFLPLYISYVAMnFHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15383    8 FVLFVLSACSNLAVLWsaTRNRRRKLSHVRILILHLAAADlLVTFVVMPLDAAWNVT-VQWYAGDLACRLLMFLKLFAMY 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRtlKNSLIVIIFIWLLASLIGGPALYFRDTVEFN---NHTLC--YNNFQKHDPD 197
Cdd:cd15383   87 SSAFVTVVISLDRHAAILNPLAIGSAR--RRNRIMLCAAWGLSALLALPQLFLFHTVTATppvNFTQCatHGSFPAHWQE 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 LTlirHHVLTwvkFIIGYLFPLLTMSICYLCLIFKVKKR-----------------SILISSRHFWTI---LVVVVAFVV 257
Cdd:cd15383  165 TL---YNMFT---FFCLFLLPLLIMIFCYTRILLEISRRmkekkdsaknevalrssSDNIPKARMRTLkmtIVIVSSFIV 238
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 387763613 258 CWTPYHLFSIW-----ELTIHHNS-YSHHVMqagipLSTGLafLNSCLNPILYVLISKKFQARF 315
Cdd:cd15383  239 CWTPYYLLGLWywfspEMLEQTVPeSLSHIL-----FLFGL--LNACLDPLIYGLFTISFRRGL 295
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
43-315 3.52e-15

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 74.96  E-value: 3.52e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVI-WFTGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYIS-YVAMNfhWPFGIWLCKANSFTAQL 119
Cdd:cd15123    5 VTYAVIISVGILGNAILIkVFFKIKSMQTVPNIFITSLAFGDLLLLLTcVPVDATrYIADT--WLFGRIGCKLLSFIQLT 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 120 NMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFN--NHTLCYNNFQKHdPD 197
Cdd:cd15123   83 SVGVSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVFSDLYSFRdpEKNTTFEACAPY-PV 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 LTLIRHHVLTWVKFIIGYLFPLLTMSICYLcLIFKVKKRSIL-------------ISSRH--FWTILVVVVAFVVCWTPY 262
Cdd:cd15123  162 SEKILQEIHSLLCFLVFYIIPLSIISVYYF-LIARTLYKSTFnmpaeehsharkqIESRKrvAKTVLVLVALFAFCWLPN 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 387763613 263 HLFSIWELTIHHNSYSHHVMQAGIPL-STGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15123  241 HILYLYRSFTYHTSVDSSAFHLIATIfSRVLAFSNSCVNPFALYWLSKSFRQHF 294
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
44-312 5.25e-15

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 74.42  E-value: 5.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15369    6 VYTIVFVISLPLNILALVVFLRKMRvKKPAVIYMLNLACADLLFVLLLPFKIAYHFSGNDWLFGEAMCRVVTAAFYCNMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFN--NHTLCYNNFQKHDpdltL 200
Cdd:cd15369   86 CSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQTIQIPdlGITTCHDVLNEQL----L 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRHHVLTWVKFIIGYLF-PLLTMSICYLCLIFKVKKRSILISS----RHFWTILVVVVAFVVCWTPYHLFSIWELTIHHN 275
Cdd:cd15369  162 MGYYVYYFSIFSCLFFFvPLIITTVCYVSIIRCLSSSSDVANSskktRALFMAVAVFCVFVICFGPTNVLLLAHYVRFAY 241
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 387763613 276 SYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15369  242 TSTNDASYFAYLLCVCVGSISCCLDPLIYYYGSSQCQ 278
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
46-308 5.87e-15

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 74.33  E-value: 5.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  46 CLAFVLGIPGNAIVI-WFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLY-ISYVAMnFHWPFGIWLCKANSFTAQLNMFA 123
Cdd:cd14986    8 GVLFVFTLVGNGLVIlVLRRKRKKRSRVNIFILNLAIADLVVAFFTVLTqIIWEAT-GEWVAGDVLCRIVKYLQVVGLFA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 124 SVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIifIWLLASLIGGPALY-FRDTVEFNNHTLCYNNF--QKHdpdltl 200
Cdd:cd14986   87 STYILVSMSLDRYQAIVKPMSSLKPRKRARLMIVV--AWVLSFLFSIPQLViFVERELGDGVHQCWSSFytPWQ------ 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 iRHHVLTWVKFIIgYLFPLLTMSICYLCLIFKVKKRSI-------------------------LISSRHFWTI---LVVV 252
Cdd:cd14986  159 -RKVYITWLATYV-FVIPLIILSYCYGRILRTIWIRSRqktdrpiaptamscrsvscvssrvsLISRAKIKTIkmtLVII 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 387763613 253 VAFVVCWTPYHLFSIWELtihHNSYSHHVMQAGIPLSTgLAFLNSCLNPILYVLIS 308
Cdd:cd14986  237 LAFILCWTPYFIVQLLDV---YAGMQQLENDAYVVSET-LASLNSALNPLIYGFFS 288
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
41-313 9.09e-15

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 73.70  E-value: 9.09e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  41 SLVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQL 119
Cdd:cd15391    3 LINLYQSTIFLSVGGNYSVIVvFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 120 NMFASVFFLTVISLDHYIHLIHPVlsHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLT 199
Cdd:cd15391   83 SVTASVLTNTAIGIDRFFAVIFPL--RSRHTKSRTKCIIASIWAISFSLSSVQLFAGRTQRYGQYSEGRVLCGESWPGPD 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 LIRhHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSI------------LISSRHFWTILVVVVAFV-VCWTPYHLFS 266
Cdd:cd15391  161 TSR-SAYTVFVMLLTYIIPLLILTSTYGYVGFRLWNRTApgnadkgrddmqIKSKRKVIKMLVFVVLMFgICWLPLHLFN 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 387763613 267 IW-ELTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQA 313
Cdd:cd15391  240 LVqDFSTVFRNMPQHTTRLIYGACHWIAMSNSFVNPIIYLFMNDSFRS 287
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-313 1.27e-14

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 73.29  E-value: 1.27e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLaFVLGIPGNAIVIWFTG-FKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQ 118
Cdd:cd15132    3 VTIVCLIL-FVVGVTGNTMTVLIIRrYKDMRTTTNLYLSSMAVSDLLILLCLPFDLYRLWKSRPWIFGEFLCRLYHYISE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQ-KHDP- 196
Cdd:cd15132   82 GCTYATILHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPFLFLVGVEQDNNIHPDDFSREcKHTPy 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 DLTLIRHHVLTWVKFIIgYLFPLLTMSICY---LCLIFKVKKR-----SILISSRHFWTI---LVVVVAFVVCWTPYHLF 265
Cdd:cd15132  162 AVSSGLLGIMIWVTTTY-FFLPMLCLSFLYgfiGRKLWKSKNDlrgpnAAARERSHRQTVrilAVVVLAFIICWLPFHIG 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 387763613 266 SIweltIHHNSYSHHVM---QAGIPLSTGLAFLNSCLNPILYVLISKKFQA 313
Cdd:cd15132  241 RI----LFANTEDYRTMmfsQYFNIVAMQLFYLSASINPILYNLISRKYRA 287
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
43-312 1.35e-14

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 73.23  E-value: 1.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNfHWPFGIWLCKANSFTAQLN 120
Cdd:cd15397    5 VSYSLVMAVGLLGNICLICvIARQKEKTNVTNILIANLSFSDILVCLVcLPFTVVYTLMD-YWIFGEVLCKMTPFIQCMS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPvlSHRHRTLKNSLIVIIFIWLLASLIGGPALYFR--DTVEFNNHTLCYNNFQKHD--P 196
Cdd:cd15397   84 VTVSILSLVLIALERHQLIINP--TGWKPSVSQAYLAVVVIWMLACFISLPFLAFHilTDEPYKNLSHFFAPLADKAvcT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 DLTLIRHHVLTWVKFII--GYLFPLLTMSICYLCLIFKVKKRSILI------------SSRHFWTILVVVVAFVVCWTPY 262
Cdd:cd15397  162 ESWPSEHHKLAYTTWLLlfQYCLPLLFILVCYLRIYLRLRRRKDMLerrgeynrraghSKRINVMLVSLVAAFALCWLPL 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 387763613 263 HLFSI---WeltiHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15397  242 NVFNAiadW----NHEAIPHCQHNLIFSLCHLAAMASTCVNPIIYGFLNSNFK 290
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
39-315 1.54e-14

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 73.05  E-value: 1.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYI--SYVAMNFHWPFGIW--LCKAN 113
Cdd:cd14978    1 VLYGYVLPVICIFGIIGNILNLVVLTRKSMRSSTNVYLAALAVSDILVLLSaLPLFLlpYIADYSSSFLSYFYayFLPYI 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 114 SFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNN------HTLC 187
Cdd:cd14978   81 YPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENcnnnsyYYVI 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 188 YNNFQKHDPDLTLIRHhvltWVKFIIGYLFPLLTMSICYLCLIFKV---KKRSILISSRHFW-------------TILVV 251
Cdd:cd14978  161 PTLLRQNETYLLKYYF----WLYAIFVVLLPFILLLILNILLIRALrksKKRRRLLRRRRRLlsrsqrrerrttiMLIAV 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 387763613 252 VVAFVVCWTPYHLFSIWElTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd14978  237 VIVFLICNLPAGILNILE-AIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
43-312 1.67e-14

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 72.87  E-value: 1.67e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfhWPFGIWLCKANSFTAQLNM 121
Cdd:cd15923    5 AIYIPTFVLGLLLNILALWvFCWRLKKWTETNIYMTNLAVADLLLLISLPFKMHSYRRE--SAGLQKLCNFVLSLYYINM 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTvefNNHTLCYNNFQKHDPdltli 201
Cdd:cd15923   83 YVSIFTITAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIPYFLLDSS---NEKTMCFQRTKQTES----- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWVkfIIGYLFPLLTMSICYLCLIFKVKKR-----SILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNS 276
Cdd:cd15923  155 LKVFLLLE--IFGFLLPLIIMTFCSARVIHTLQKRlddvgSRSETKQCIRVIMANLIVFIVCFLPVHVGFFVKFIVGKSY 232
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 387763613 277 YSHHVMQAG--IPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15923  233 SCDSKLIIHffLQSAFCLSDMNCCLDAFCYYFATKEFR 270
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
40-315 3.76e-14

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 71.78  E-value: 3.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIF-LLFLPLYISYvAMNFHWPFGIWLCKANSFTAQ 118
Cdd:cd15295    3 LLFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVgAISIPLYIPY-TLTNRWDFGRGLCVFWLVIDY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVlSHRHRTLKNSLIVIIF--IWLLASLIGGPALYFRDTVEfNNHTLCYNNFQKHDP 196
Cdd:cd15295   82 LLCTASVYNIVLISYDRYQSVSNAV-SYRNQQTATLRIVTQMvaVWVLAFLVHGPAILVSDSWK-TEDGECEPEFFSNWY 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 DLTLIRhhvltwvkfIIGYLFPLLTMSICYLCLIFKVKKRsiLISSRHFWTILVVVVAFVVCWTPYHLFsiwelTIHHNS 276
Cdd:cd15295  160 ILAITS---------VLEFLVPVILVAYFNTQIYWSLWKR--LRDRKLAKSLAIILGTFAICWAPYSLF-----TIIRAA 223
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 387763613 277 YSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15295  224 CEKHRGSPWYNFAFWLQWFNSFINPFLYPLCHKRFRKAF 262
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
46-315 5.20e-14

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 71.50  E-value: 5.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  46 CLAFVlgipGNAIVIW--FTGFKWKKTVTTLWFLNLAIADFIFLLFLpLYISYVAMNFHWPFGI----WL----CKANSF 115
Cdd:cd14980   12 ILALI----GNILVIIwhISSKKKKKKVPKLLIINLAIADFLMGIYL-LIIAIADQYYRGRYAQyseeWLrsppCLLACF 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 116 TAQLNMFASVFFLTVISLDHYIHLIHPVLSHRhRTLKNSLIVIIFIWLLA-SLIGGPALYfrdTVEFNNHTLCY------ 188
Cdd:cd14980   87 LVSLSSLMSVLMMLLITLDRYICIVYPFSNKR-LSYKSAKIILILGWLFSiIFAAIPILY---SINQPGDNRLYgyssic 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 189 --NNFQKHDPDLTLIRHHVLTWVKFIIgylfplltMSICYLCLIFKVKKRSILISS----------RHFWTILvvvVAFV 256
Cdd:cd14980  163 mpSNVSNPYYRGWLIAYLLLTFIAWII--------ICILYILIFISVRKSRKSARRssskrdkriaIRLALIL---ITDL 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 387763613 257 VCWTPYHLFSIWELtIHHNSYSHHVMQAGIPLSTGlafLNSCLNPILYVLISKKFQARF 315
Cdd:cd14980  232 ICWLPYYIVIFSGL-LTSTEIDIHVLQFIAILALP---LNSAINPYLYTLTTPTFKRDF 286
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
38-315 1.28e-13

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 70.03  E-value: 1.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  38 HWVSLVLYCLAFVlGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIAD-FIFLLFLPLYISYVAMNFHWPFGIWLCKANSF 115
Cdd:cd15052    1 NWAALLLLLLVIA-TIGGNILVCLAISLEKRlQNVTNYFLMSLAIADlLVGLLVMPLSILTELFGGVWPLPLVLCLLWVT 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 116 TAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGP--ALYFRDTVEFNNHTLCYNNFqk 193
Cdd:cd15052   80 LDVLFCTASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPipVLGIIDTTNVLNNGTCVLFN-- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 194 hdpdltliRHHVLtwVKFIIGYLFPLLTMSICYlCLIFKvkkrsILISSRHFWTIL-VVVVAFVVCWTPYhlFSIWELTI 272
Cdd:cd15052  158 --------PNFVI--YGSIVAFFIPLLIMVVTY-ALTIR-----LLSNEQKASKVLgIVFAVFVICWCPF--FITNILTG 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 387763613 273 HHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15052  220 LCEECNCRISPWLLSVFVWLGYVSSTINPIIYTIFNKTFRRAF 262
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
42-312 1.90e-13

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 69.47  E-value: 1.90e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAFVLG---IPGNAIV-IWFTGFKWKKTVTTLWFLNLAIADF-IFLLFLPLYISYVAMNfHWPFGIWLCKANSFT 116
Cdd:cd15301    1 VLIVIVAAVLSlvtVGGNVMVmISFKIDKQLQTISNYFLFSLAVADFaIGVISMPLFTVYTALG-YWPLGYEVCDTWLAI 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 117 AQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYF------RDTVEFNNhtlCYNN 190
Cdd:cd15301   80 DYLASNASVLNLLIISFDRYFSVTRPLTYRARRTTKKAAVMIASAWIISLLLWPPWIYSwpyiegKRTVPAGT---CYIQ 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 191 FqkhdpdltLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWEL 270
Cdd:cd15301  157 F--------LETNPYVTFGTALAAFYVPVTIMCILYWRIWRETKKRQKKQESKAAKTLSAILLAFIVTWTPYNVLVLIKA 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 387763613 271 TIhhnSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15301  229 FF---PCSDTIPTELWDFSYYLCYINSTINPLCYALCNAAFR 267
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
43-312 1.92e-13

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 69.83  E-value: 1.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYvamnFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15920    5 VMYSIICIVGLLSNTLALWvFFLRQQRETSISVYMRNLALADLLLVLCLPFRVAY----QNTAGPLSFCKIVGAFFYLNM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYfrdtVEFNNHTLCYNNFQKHDPDLTLI 201
Cdd:cd15920   81 YASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIPFLF----ESRNEGPCDNKCFHFRSKGLTAG 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWVKFIIGYLFPLLTmsicYLCLIFKVKKRSIL--------ISSRHFWTILVVVVAFVVCWTPYHLFSI----WE 269
Cdd:cd15920  157 GINLTAVVIFYILSLLFLYF----YAKISHKLYKVSLGnaqqqikkASKRAIIKTFIVLAIFIVCFVPYHIVRVpyvlAQ 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 387763613 270 LTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15920  233 IDVISSLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFR 275
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
43-311 2.68e-13

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 69.23  E-value: 2.68e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKK-TVTTLWFLNLAIADFIFLLFL-PLYISYvAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15074    5 IYLTVIGILSTLGNGTVLFVLYRRRSKlKPAELLTVNLAVSDLGISVFGyPLAIIS-AFAHRWLFGDIGCVFYGFCGFLF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPvlSHRHR-TLKNSLIVIIFIWLLASLIGGPAL----YFRDTVefnNHTLCYNNFQKHD 195
Cdd:cd15074   84 GCCSINTLTAISIYRYLKICHP--PYGPKlSRRHVCIVIVAIWLYALFWAVAPLvgwgSYGPEP---FGTSCSIDWTGAS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 196 PDLTlirHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKK----RSILISSRHFWTILVVVVAFVVC---------WTPY 262
Cdd:cd15074  159 ASVG---GMSYIISIFIFCYLLPVLIIVFSYVKIIRKVKSsrkrVAGFDSRSKRQHKIERKVTKVAVlicagfliaWTPY 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 387763613 263 HLFSIWelTIHHNSYSHHVMQAGIPlsTGLAFLNSCLNPILYVLISKKF 311
Cdd:cd15074  236 AVVSMW--SAFGSPDSVPILASILP--ALFAKSSCMYNPIIYLLFSSKF 280
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
40-315 2.71e-13

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 69.00  E-value: 2.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIW--FTgFKWKKTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNfHWPFGIWLCKANSFT 116
Cdd:cd15060    2 VTTILLSVIIAFTIVGNILVILsvFT-YRPLRIVQNFFIVSLAVADLAVAIFvLPLNVAYFLLG-KWLFGIHLCQMWLTC 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 117 AQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALyfrdtVEFNNHTlcyNNFQKHDP 196
Cdd:cd15060   80 DILCCTASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPL-----IGWNDWP---ENFTETTP 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 -DLTLIRHHVltwVKFIIGYLF-PLLTMSICYLCLIFKVKKRsilisSRHFWTILVVVVAFVVCWTPYHLFSIWeLTIHH 274
Cdd:cd15060  152 cTLTEEKGYV---IYSSSGSFFiPLLIMTIVYVKIFIATSKE-----RRAARTLGIIMGVFVVCWLPFFLMYVI-LPFCE 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 387763613 275 NSYSHHVMQAGIplsTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15060  223 TCSPSAKVVNFI---TWLGYVNSALNPVIYTIFNLDFRRAF 260
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
40-315 2.71e-13

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 69.13  E-value: 2.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQ 118
Cdd:cd15978    2 VRILLYSLIFLLSVLGNSLIIAvLIRNKRMRTVTNIFLLSLAVSDLMLCLFCMPFTLIPNLLKDFIFGSAVCKTATYFMG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDL 198
Cdd:cd15978   82 ISVSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPFTRINNSTGNMCRLLWPN 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 TLIRHhvlTWVKF--IIGYLFPLLTMSICYLCLIFKVKK--RSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELtihH 274
Cdd:cd15978  162 DVTQQ---SWYIFllLILFLIPGIVMMTAYGLISLELYRgiKFLMAKKRVIRMLIVIVILFFLCWTPIFSANAWRA---F 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 387763613 275 NSYSHHVMQAGIPLS--TGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15978  236 DTRSADRLLSGAPISfiHLLSYTSACVNPIIYCFMNKRFRMGF 278
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
43-226 4.01e-13

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 68.76  E-value: 4.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYIsYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15079    5 FIYIFLGIVSLLGNGLVIYiFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFI-YNSFYEGWALGPLGCQIYAFLGSLSG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPvLSHRHRTLKNSLIVIIFIWLLASLIGGPALYF---RDTVEfNNHTLCYNNFQKHDpdl 198
Cdd:cd15079   84 IGSIWTNAAIAYDRYNVIVKP-LNGNPLTRGKALLLILFIWLYALPWALLPLLFgwgRYVPE-GFLTSCSFDYLTRD--- 158
                        170       180
                 ....*....|....*....|....*...
gi 387763613 199 TLIRHHVLTWvkFIIGYLFPLLTMSICY 226
Cdd:cd15079  159 WNTRSFVATI--FVFAYVIPLIIIIYCY 184
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
43-311 5.19e-13

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 68.06  E-value: 5.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAF-VLGIPGNAIVIwFTGFKWKK--TVTTLWFLNLAIADFIFLLF-LPLYISyVAMNFHWPFGIWLCKANSFTAQ 118
Cdd:cd15210    4 AVWGIVFmVVGVPGNLLTV-LALLRSKKlrTRTNAFIINLSISDLLFCAFnLPLAAS-TFLHQAWIHGETLCRVFPLLRY 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFqkhdpdL 198
Cdd:cd15210   82 GLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLWLGIWGRFGLDPKVCSCSI------L 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 TLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFwtilvvvvafVVCWTPYHLFSIWE-LTIHHNsy 277
Cdd:cd15210  156 RDKKGRSPKTFLFVFGFVLPCLVIIICYARREDRRLTRMMLVIFLCF----------LVCYLPITLVNVFDdEVAPPV-- 223
                        250       260       270
                 ....*....|....*....|....*....|....
gi 387763613 278 sHHVMqagiplSTGLAFLNSCLNPILYVLISKKF 311
Cdd:cd15210  224 -LHII------AYVLIWLSSCINPIIYVAMNRQY 250
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
40-304 5.37e-13

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 68.49  E-value: 5.37e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGN--AIVIWFTGFKWKKTVTTLWFLNLAIADFIF-LLFLPLYISYVAMNfHWPFGIWLCKANSFT 116
Cdd:cd15382    2 VSIIVYSVLFLIAAVGNltVLLILLRNRRRKRSRVNILLMHLAIADLLVtFIMMPLEIGWAATV-AWLAGDFLCRLMLFF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 117 AQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRtlKNSLIVIIFIWLLASLIGGPALY-FRdtVE----FNNHTLC--YN 189
Cdd:cd15382   81 RAFGLYLSSFVLVCISLDRYFAILKPLRLSDAR--RRGRIMLAVAWVISFLCSIPQSFiFH--VEshpcVTWFSQCvtFN 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 190 NFQKHDpdltlirhHVLTWVKF--IIGYLFPLLTMSICYLCLIFKVKKRS---------------ILISSRHFWT----- 247
Cdd:cd15382  157 FFPSHD--------HELAYNIFnmITMYALPLIIIVFCYSLILCEISRKSkekkedvseksssvrLRRSSVGLLErarsr 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 387763613 248 ----ILVVVVAFVVCWTPYHLFSIWELTIHHN-SYSHHVMQAGIPLstgLAFLNSCLNPILY 304
Cdd:cd15382  229 tlkmTIVIVLVFIICWTPYFIMSLWYWFDRESaSKVDPRIQKGLFL---FAVSNSCMNPIVY 287
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
43-312 6.51e-13

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 68.30  E-value: 6.51e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGN-AIVIWFTGFKWKKTVTTLWFLNLAIADFIF-LLFLPLYISYVAMNfHWPFGIWLCKANSFTAQLN 120
Cdd:cd15395    5 LAYSAVIILGVSGNlALIIIILKQKEMHNVTNILIVNLSFSDLLMtIMCLPFTFVYTLMD-HWVFGEAMCKLNSMVQCIS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPvlSHRHRTLKNSLIVIIFIWLLASLIGGPALYF---------RDTVEFNNHT---LCY 188
Cdd:cd15395   84 ITVSIFSLVLIAIERHQLIINP--RGWRPNNRHAYVGIAVIWVLAVLTSLPFLIFqvltdepfkNVNVSLDAYKgkyVCL 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 189 NNFQKHDPDLTlirhhvLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILI------------SSRHFWTILVVVVAFV 256
Cdd:cd15395  162 DQFPSDTIRLS------YTTCLLVLQYFGPLCFIFICYLKIYIRLKRRNNMMdkmrdnkyrsseTKRINIMLISIVVAFA 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 387763613 257 VCWTPYHLFSI---WELTIHHNSySHHVMQAGIPLStglAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15395  236 VCWLPLNIFNAvfdWNHEAIATC-NHNLLFLICHLT---AMISTCVNPIFYGFLNKNFQ 290
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
40-315 6.62e-13

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 67.77  E-value: 6.62e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLgIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIF-LLFLPLYISYVAMNFHWPFGIWLCKANSFTA 117
Cdd:cd15067    2 LGVVLSLFCLVT-VAGNLLVILaVLRERYLRTVTNYFIVSLAVADLLVgSIVMPFSILHEMTGGYWLFGRDWCDVWHSFD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 118 QLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPA-LYFRDTVEFNNHTlcynnFQKHDP 196
Cdd:cd15067   81 VLASTASILNLCVISLDRYWAITDPISYPSRMTKRRALIMIALVWICSALISFPAiAWWRAVDPGPSPP-----NQCLFT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 DLTLIRhHVLTWVKFIIgylfPLLTMSICYlCLIFkvkkRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNS 276
Cdd:cd15067  156 DDSGYL-IFSSCVSFYI----PLVVMLFTY-YRIY----RAAAKEQKAAKTLGIVMGVFILCWLPFFVTNILIGFCPSNC 225
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 387763613 277 YSHhvMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15067  226 VSN--PDILFPLVTWLGYINSGMNPIIYACSSRDFRRAF 262
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
43-315 7.45e-13

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 68.32  E-value: 7.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIV-IWFTGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15133    5 LTYLLIFVVGVVGNVLTcLVIARHKAMRTPTNYYLFSLAVSDLLVLLLgMPLELYELWQNYPFLLGSGGCYFKTFLFETV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTlcynnfqkhdPDLTL 200
Cdd:cd15133   85 CLASILNVTALSVERYIAVVHPLAARTCSTRPRVTRVLGCVWGVSMLCALPNTSLHGIKFLGSGV----------PASAQ 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRHHVLTWV-KFIIG------YLFPLLTMSICYLCLIFKVKKRSILISSRHFWTI---------------------LVVV 252
Cdd:cd15133  155 CTVRKPQAIyNMIPQhtghlfFVLPMAVISVLYLLMALRLARERGLDATGAGSKIgtrtgqllqhprtraqvtkmlFILV 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 387763613 253 VAFVVCWTPYHLFSIWELTIHHNSYSHHVMQAGIPLSTGLAF-LNSCLNPILYVLISKKFQARF 315
Cdd:cd15133  235 VVFAICWAPFHIDRLMWSFISDWTDNLHEVFQYVHIISGVFFyLSSAVNPILYNLMSTRFREMF 298
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
39-312 8.43e-13

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 67.93  E-value: 8.43e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNA-IVIWFTGFKWKKTVTTLWFLNLAIADFIflLFLPLYISYVAMNFHWPFGIWLCKANSFTA 117
Cdd:cd14989    1 FLSCLYTIFLFPIGFIGNIlILVVNLSFREKMTIPDLYFVNLAVADLI--LVADSLIEVFNLNEKYYDIAVLCTFMSLFL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 118 QLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWL---LASLIGGPALYFRDTVEFnnhTLCYNNFQKh 194
Cdd:cd14989   79 QINMYSSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMasiSATLLPFTAVQAQHTGEV---HFCFADVRE- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 195 dpdltlirhhvLTWVKFIIGYLFPLLTMSICYlCLIFKV-----KKRSI-LISSRHFWTILVVVVAFVVCWTPYHLF--- 265
Cdd:cd14989  155 -----------IQWLEVTLGFIIPFSIIGLCY-SLIVRVlvraqKHRRLrPRRQKALRMILVVVLVFFICWLPENVFisi 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 387763613 266 -----------SIWELTIHHNSYSHHVMQAGiplstglAFLNSCLNPILYVLISKKFQ 312
Cdd:cd14989  223 qllqgtqepseSYDESFRHNHPLTGHIVNLA-------AFSNSCLNPLIYSFLGETFR 273
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
39-315 9.78e-13

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 67.53  E-value: 9.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIWFTGF-KWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTA 117
Cdd:cd15979    1 TVRILLYSVIFLLSVFGNMLIIVVLGLnKRLRTVTNSFLLSLALSDLMLAVFCMPFTLIPNLMGTFIFGEVICKAVAYLM 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 118 QLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPD 197
Cdd:cd15979   81 GVSVSVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVPVPVGDRPRGHQCRHAWP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 LTLIRHhvlTWVKFIIGYLF--PLLTMSICYlCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWElTIHHN 275
Cdd:cd15979  161 SAQVRQ---AWYVLLLLILFfiPGVVMIVAY-GLISRELYRGLLAKKRVIRMLVVIVAMFFLCWLPIFSANTWR-AFDPL 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 387763613 276 SYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15979  236 SAHRALSGAPISFIHLLSYTSACVNPLVYCFMNRRFRKAF 275
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
43-314 9.80e-13

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 67.75  E-value: 9.80e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTgFKWKK--TVTTLWFLNLAIAD-FIFLLFLPLYISYVaMNFHWPFGIWLCKANSFTAQL 119
Cdd:cd15389    5 VAYSIIIVISLFGNSLVCHVI-FKNKRmhTATNLFIVNLAVSDiLITLLNTPFTLVRF-VNSTWVFGKIMCHLSRFAQYC 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 120 NMFASVFFLTVISLDHYIHLIHPvLSHRHRTLKNSLIVIIfIWLLASLIGGPALYFRDTVEF---NNHTLCYNNFQKHDP 196
Cdd:cd15389   83 SVYVSTLTLTAIALDRHRVILHP-LKPRITPCQGVVVIAI-IWIMASCLSLPHAIYQKLVEFeysNERTRSRCLPSFPEP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 DLTLIRHhvLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSIL---ISSRHFWTI----------LVVVVAFVVCWTP-- 261
Cdd:cd15389  161 SDLFWKY--LDLATFILQYVLPLLIIGVAYTRVAKKLWLRNAIgdvTTEQYVAQRrkkkktikmlMLVVLLFAICWLPln 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 387763613 262 -YHLFSIWELTIHHNS--YSHHvmqagiplstGLAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd15389  239 cYHVLLSSHPIRSNSAlfFAFH----------WLAMSSTCYNPFIYCWLNDSFRSE 284
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
44-315 9.97e-13

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 67.39  E-value: 9.97e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVI-WFTGFKWKKTVTTLWFLNLAIADFIF-LLFLPLYISYVAMNFhWPFGIWLCKansFTAQLNM 121
Cdd:cd15061    5 FLILAIIFTIFGNLLVIlAVATTRRLRTITNCYIVSLATADLLVgVLVLPLAIIRQLLGY-WPLGSHLCD---FWISLDV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 F---ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYfrdtvefnnhtLCYNNFQKHDPDL 198
Cdd:cd15061   81 LlctASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLV-----------GPSWHGRRGLGSC 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 TLIRHHVLTWVKFIIGYLFPLLTMSICYlCLIFKVKKRsiliSSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYs 278
Cdd:cd15061  150 YYTYDKGYRIYSSMGSFFLPLLLMLFVY-LRIFRVIAK----ERKTAKTLAIVVGCFIVCWLPFFIMYLIEPFCDCQFS- 223
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 387763613 279 hhvmQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15061  224 ----EALSTAFTWLGYFNSVINPFIYAFYNKDFRRAF 256
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
38-316 1.20e-12

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 67.16  E-value: 1.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  38 HWVSLvLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFL-NLAIADFIFLLF-LPLYISYVAMNFHWPFGIWLCKANSF 115
Cdd:cd15306    1 HWAAL-LILMVIIPTIGGNILVILAVSLEKKLQYATNYFLmSLAVADLLVGLFvMPIALLTILFEAMWPLPLVLCPIWLF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 116 TAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALY--FRDTVEFNNHTLCYnnfqk 193
Cdd:cd15306   80 LDVLFSTASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPVPIkgIETDVDNPNNITCV----- 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 194 hdpdLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIweLTIH 273
Cdd:cd15306  155 ----LTKERFGDFILFGSLAAFFTPLAIMIVTYFLTIHALRKQTITNEQRASKVLGIVFFLFLLMWCPFFITNI--TSVL 228
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 387763613 274 HNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARFR 316
Cdd:cd15306  229 CDSCNQTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFRDAFG 271
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
50-315 1.36e-12

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 67.11  E-value: 1.36e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  50 VLGIPGNAIVIwFTGFKWKK--TVTTLWFLNLAIADFIFLLF-LPLYISYVAMNfHWPFGIWLCKANSFTAQLNMFASVF 126
Cdd:cd15209   12 VVDVLGNLLVI-LSVLRNKKlrNAGNIFVVSLSVADLVVAIYpYPLILHAIFHN-GWTLGQLHCQASGFIMGLSVIGSIF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 127 FLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFrDTVEFNNHTLCYNNFQKHDPdltlirhhVL 206
Cdd:cd15209   90 NITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNFFI-GSLQYDPRIYSCTFAQTVST--------VY 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 207 TWVKFIIGYLFPLLTMSICYL---CLIFKVKKRSILISS--------RHFWTILVVVVAFVVCWTPYHLFSIwELTIHHN 275
Cdd:cd15209  161 TITVVVIHFLLPLLIVSFCYLriwVLVLQVRQRVKPDQRpklkpadvRNFLTMFVVFVLFAVCWAPLNFIGL-AVAINPK 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 387763613 276 SYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15209  240 EMAPKIPEWLFVASYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
40-315 1.96e-12

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 66.83  E-value: 1.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIWFT-GFKWKKTVTTLWFLNLAIADF---IFLLFLPLYISYVAmnfHWPFGIWLCKANSF 115
Cdd:cd15980    2 VFIASYLLIFLLCMMGNGVVCFIVlRSKHMRTVTNLFILNLAISDLlvgIFCMPTTLLDNIIA---GWPFGSTVCKMSGM 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 116 TAQLNMFASVFFLTVISLDHYIHLIHPVlsHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHD 195
Cdd:cd15980   79 VQGISVSASVFTLVAIAVDRFRCIVYPF--KQKLTISTAVVIIVIIWVLAIAIMCPSAVMLHVQEEKNYRVVLGSQNKTS 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 196 PdLTLIRHH--------VLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRH---------------FWTILVVV 252
Cdd:cd15980  157 P-VYWCREDwpnqemrkIYTTVLFANIYLAPLSLIVIMYARIGITLFKTAMPHTGKHnqeqrhvvsrkkqkvIKMLLIVA 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 387763613 253 VAFVVCWTPyhLFSIWELTIHHNSYSHHVMQAGI---PLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15980  236 LLFILSWLP--LWTLMMLSDYANLSPNQLQIINIyiyPFAHWLAFFNSSVNPIIYGFFNENFRRGF 299
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
47-316 2.58e-12

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 66.51  E-value: 2.58e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  47 LAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIF-LLFLPLYISYVAMNfHWPFGIWLCKANSFTAQLNMFASV 125
Cdd:cd15299   13 LALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIgVISMNLFTTYIIMN-RWALGNLACDLWLSIDYVASNASV 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 126 FFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYF------RDTVEFNNhtlCYNNFqkhdpdlt 199
Cdd:cd15299   92 MNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFwqyfvgKRTVPPDE---CFIQF-------- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 lIRHHVLTWVKFIIGYLFPLLTMSICYlcliFKVKKRSILiSSRHFWTILVVVVAFVVCWTPYHLFSIWeltihhNSYSH 279
Cdd:cd15299  161 -LSEPIITFGTAIAAFYLPVTIMTILY----WRIYKETIK-EKKAAQTLSAILLAFIITWTPYNIMVLV------NTFCD 228
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 387763613 280 HVMQAGI-PLSTGLAFLNSCLNPILYVLISKKFQARFR 316
Cdd:cd15299  229 SCIPKTYwNLGYWLCYINSTVNPVCYALCNKTFRTTFK 266
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
47-311 3.09e-12

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 66.20  E-value: 3.09e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  47 LAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIF-LLFLPLYIsYVAMNFHWPFGIWLCKANSFTAQLNMFAS 124
Cdd:cd15083    9 IIGLIGVVGNGLVIYaFCRFKSLRTPANYLIINLAISDFLMcILNCPLMV-ISSFSGRWIFGKTGCDMYGFSGGLFGIMS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 125 VFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALY-FRDTVEFNNHTLCYNNFQKHDPdltLIRH 203
Cdd:cd15083   88 INTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLWVLPPLFgWSRYVLEGLLTSCSFDYLSRDD---ANRS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 204 HVLtwVKFIIGYLFPLLTMSICYLCLIFKVKK------------RSILISSRH---------FWTILVVVVAFVVCWTPY 262
Cdd:cd15083  165 YVI--CLLIFGFVLPLLIIIYCYSFIFRAVRRhekamkemakrfSKSELSSPKarrqaevktAKIALLLVLLFCLAWTPY 242
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 387763613 263 HLFSiwelTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKF 311
Cdd:cd15083  243 AVVA----LIGQFGYLEVLTPLATAIPAAFAKTSAIYNPVIYAFSHPKF 287
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
39-315 3.12e-12

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 65.87  E-value: 3.12e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVI---WFTgfKWKKTVTTLWFLNLAIADFIFLL--FLPLYISYVAMNFHWPFGIWLCKAN 113
Cdd:cd14995    1 VVATFLVLLICGVGIVGNIMVVlvvLRT--RHMRTPTNCYLVSLAVADLMVLVaaGLPNEIESLLGPDSWIYGYAGCLLI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 114 SFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDT--VEFNNHTLCYNNF 191
Cdd:cd14995   79 TYLQYLGINASSLSITAFTIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLsiKHYGDDIVVRCGY 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 192 QkhdpdltLIRHHVLT--WVKFIIGYLFPLLTMSICYLCLIFkvkkrsILISSRHFWT--ILVVVVAFVVCWTPYHLFSI 267
Cdd:cd14995  159 K-------VSRHYYLPiyLADFVLFYVIPLLLAIVLYGLIGR------ILFSSRKQVTkmLAVVVVLFALLWMPYRTLVV 225
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 387763613 268 WeltihhNSYSHHVMQAG--IPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd14995  226 Y------NSFASPPYLDLwfLLFCRTCIYLNSAINPILYNLMSQKFRAAF 269
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
43-314 3.38e-12

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 65.93  E-value: 3.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15924    5 VLYTVIFFAGILLNGLAMWIFFHIPSKSSFIIYLKNTVVADLLMILTFPFKILSDAGLGPWQLRTFVCRVTSVLFYFTMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGP--ALYFRDTVEFNNHTLcynnfQKHDPDLTL 200
Cdd:cd15924   85 TSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSLPnmILTNQQPREKNVKKC-----SFLKSELGL 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRHHVLTWVkFIIGYLFPLLTMSICYL---CLIFKVKKRSILISS----RHFWTILVVVVAFVVCWTPYHL----FSIWE 269
Cdd:cd15924  160 KWHEIVNYI-CQVIFWIVFLLMIVCYTaitKKVYRSYRRVFRSSSsrrkKSNVKIFIIVAVFFVCFVPYHFaripYTLSQ 238
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 387763613 270 LTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd15924  239 TRDVFDCTAENILFYVKEATLFLSALNVCLDPIIYFFLCKSFRES 283
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
43-315 4.10e-12

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 65.58  E-value: 4.10e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYISYVaMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15296    5 VLMALLVVATVLGNALVILaFVVDSSLRTQGNFFFLNLAISDFLVGGFcIPLYIPYV-LTGRWKFGRGLCKLWLVVDYLL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTL-KNSLIVIIFIWLLASLIGGPALYFRDtvefnnhtlcYNNFQKHDPDLT 199
Cdd:cd15296   84 CTASVFNIVLISYDRFLSVTRAVSYRAQKGMtRQAVLKMVLVWVLAFLLYGPAIISWE----------YIAGGSIIPEGE 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 LIRHHVLTWVKFIIG----YLFPLLTMSICYLCLIFKVKKRSILIS--SRHFWTILVVVVAFVVCWTPYHLFSIWELTIH 273
Cdd:cd15296  154 CYAEFFYNWYFLMTAstleFFTPFISVTYFNLSIYLNIQKRRFRLSrdKKVAKSLAIIVCVFGLCWAPYTLLMIIRAACH 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 387763613 274 HNSYSHHVMQAgiplSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15296  234 GHCVPDYWYET----SFWLLWVNSAINPVLYPLCHMSFRRAF 271
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
43-315 4.81e-12

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 65.65  E-value: 4.81e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIV-IWFTGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15357    5 LVYAVIFVVGVIGNLLVcLVILKHQNMKTPTNYYLFSLAVSDLLVLLFgMPLEVYEMWSNYPFLFGPVGCYFKTALFETV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPalyfrdtvefnnHTLCYNNFQKHDPDLTL 200
Cdd:cd15357   85 CFASILSVTTVSVERYVAILHPFRAKLNSTRERALKIIVVLWVLSVLFSIP------------NTSIHGIKLQYFPNGTL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IR-------------HHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILIS----------SRHFWT--ILVVVVAF 255
Cdd:cd15357  153 IPdsatctvvkplwiYNLIIQITSLLFYVLPMGVISVLYYLMGLKLRGDKSLEAdemnvniqrpSRKSVTkmLFVLVLVF 232
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 387763613 256 VVCWTPYHL----FSI---WELTIHHNSYSHHVmqagipLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15357  233 AICWAPFHVdrlfFSFvveWTEPLANVFNLIHV------VSGVFFYLSSAVNPIIYNLLSRRFRTAF 293
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
47-312 5.35e-12

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 65.68  E-value: 5.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  47 LAFVLGIPGNAIVIWFTG-FKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASV 125
Cdd:cd15131    9 LLFVVGVTGNLMTMLVVSkYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLCKLFQFVSESCTYSTI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 126 FFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPaLYFRDTVEFNNHTlcyNNFQKHDPDLT--LIRH 203
Cdd:cd15131   89 LNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGP-IFVLVGVEHENGT---NPIDTNECKATeyAVRS 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 204 HVLT---WVKFIIGYLfPLLTMSICYLCL---IFKVKKRSILISSRH--------FWTILVVVVAFVVCWTPYHLfsiwe 269
Cdd:cd15131  165 GLLTimvWVSSVFFFL-PVFCLTVLYSLIgrkLWRRRRENIGPNASHrdknnrqtVKMLAVVVFAFVLCWLPFHV----- 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 387763613 270 ltihHNSYSHHVMQAGIPL-----------STGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15131  239 ----GRYLFSKSFEAGSLEialisqycnlvSFVLFYLSAAINPILYNIMSKKYR 288
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
50-315 7.20e-12

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 65.26  E-value: 7.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  50 VLGIPGNAIVIwFTGFKWKK--TVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFF 127
Cdd:cd15400   12 VVDILGNLLVI-ISVFRNRKlrNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGLSVIGSIFN 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 128 LTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPAlYFRDTVEFNNHTLCYNNFQKHDPDLTLirhhvlt 207
Cdd:cd15400   91 ITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVPN-FFVGSLEYDPRIYSCTFVQTASSSYTI------- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 208 wVKFIIGYLFPLLTMSICYL---CLIFKVKK------RSILISS--RHFWTILVVVVAFVVCWTPYHLFSIwELTIHHNS 276
Cdd:cd15400  163 -AVVVIHFIVPITVVSFCYLriwVLVIQVRRkvksesKPRLKPSdfRNFLTMFVVFVIFAICWAPLNLIGL-AVAINPQE 240
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 387763613 277 YSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15400  241 MAPKVPEWLFVVSYFMAYFNSCLNAIIYGLLNQNFRKEY 279
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
44-315 7.96e-12

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 64.92  E-value: 7.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVI-WFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15124    6 VYGIIILIGLIGNITLIkIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQLTSVG 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFN----NHTLCYNNFQKHDPDL 198
Cdd:cd15124   86 VSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAVFSDLHPFYdkstNKTFVSCAPYPHSNEL 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 TLIRHHVLTwvkFIIGYLFPLLTMSICYLCLIFKV--------------KKRSILISSRHFWTILVVVVAFVVCWTPYHL 264
Cdd:cd15124  166 HPKIHSMAS---FLIFYVIPLSIISVYYYFIAKNLirsaynlpvegnvhVRRQIESRKRLAKTVLVFVGLFAFCWLPNHI 242
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 387763613 265 FSIWElTIHHN----SYSHHVMQAGIPLstgLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15124  243 IYLYR-SYHYSevdtSMLHFVSSICARI---LAFTNSCVNPFALYLLSKSFRKQF 293
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
41-227 9.20e-12

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 64.76  E-value: 9.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  41 SLVLYCLAFVLGIPGN--AIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNfHWPFGIWLCKANSFTAQ 118
Cdd:cd14983    3 SLMVYVLTILLGLPSNllALYAFVNRARLRLTPNVIYMINLCLSDLVFILSLPIKIVEALSS-AWTLPAVLCPLYNLAHF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLasLIGGPALYF---------RDTVEFNNHTLCYN 189
Cdd:cd14983   82 STLYASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWAL--VIFHVTLVFiletsggtlDINTPVGNSSTCYE 159
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 387763613 190 NFQKHDPDLTLIRHHVLTWVKFIIgylfPLLTMSICYL 227
Cdd:cd14983  160 NFTPEQLALLAPVRLELSLVLFFL----PLAITAFCYV 193
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
43-315 2.27e-11

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 64.02  E-value: 2.27e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIV-IWFTGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15358    5 VTYLLIFVVGAVGNGLTcIVILRHKVMRTPTNYYLFSLAVSDLLVLLLgMPLELYEMWSNYPFLLGAGGCYFKTLLFETV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPalyfrdtvefnnHTLCYNNFQKHDPD--- 197
Cdd:cd15358   85 CFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIP------------NTSLHGIFQLTVPCrgp 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 ------LTLIR----HHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSIL-----------------------ISSRH 244
Cdd:cd15358  153 vpdsatCMLVKprwmYNLIIQITTLLFFFLPMGTISVLYLLIGLQLKREKMLlvleakgskagdsyqhrriqqekRRRRQ 232
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 387763613 245 FWTILVVVVAFV-VCWTPYHLFSI-WELTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15358  233 VTKMLFVLVVVFgICWAPFHTDRLmWSFISQWTGELHLAFQYVHIISGVFFYLSSAANPVLYNLMSTRFREMF 305
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
42-310 2.99e-11

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 63.21  E-value: 2.99e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWF-LNLAIADFIFLLF--LPLYISYVAMNFHWPfgIWLCKANSFTAQ 118
Cdd:cd15197    4 LATLWVLFVFIVVGNSSVLFALWMRKAKKSRMNFFiTQLAIADLCVGLInvLTDIIWRITVEWRAG--DFACKVIRYLQV 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRtlKNSLIVIIFIWLLASLIGGPAL-YFRDTVEFNNHTLCYNNFQkhDPD 197
Cdd:cd15197   82 VVTYASTYVLVALSIDRYDAICHPMNFSQSG--RQARVLICVAWILSALFSIPMLiIFEKTGLSNGEVQCWILWP--EPW 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 LTLIRHHVLTWVKFIIgylfPLLTMSICYLCLIFKVKKRSIL----------------------ISSRHFWTI---LVVV 252
Cdd:cd15197  158 YWKVYMTIVAFLVFFI----PATIISICYIIIVRTIWKKSKIqvtinkaglhdgssrrsssrgiIPRAKIKTIkmtFVIV 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 387763613 253 VAFVVCWTPYHLFSIweLTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKK 310
Cdd:cd15197  234 TVFIICWSPYFVFDL--LDVFGLLPRSKTKIAAATFIQSLAPLNSAINPLIYCLFSTH 289
7tmA_MrgprX-like cd15106
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A ...
43-331 3.51e-11

primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320234  Cd Length: 274  Bit Score: 62.85  E-value: 3.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTaqLNMF 122
Cdd:cd15106    5 FLTCIISLVGLTGNAVVLWLLGFRMRRNAFSVYILNLAAADFLFLCCHIIDSLLRLINIFHIISIPKILTNVMT--FPYF 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTV-EFNNHTLCYNnfqkhdpdltlI 201
Cdd:cd15106   83 AGLSMLSAISTERCLSVLWPIWYRCHRPRHLSAVVCVLLWALSLLLSILEWKFCGFLfSGADSHWCQT-----------F 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWVKFiigyLFPLLTMSICYLCLIFKVKKRSILIsSRHFWTILVVVVAFVVCWTPYHL--FSIWELTIHHNSYSH 279
Cdd:cd15106  152 DFITTAWLIF----LFVVLCGSSLALLVRILCGSRKMPL-TRLYVTILLTVLVFLLCGLPFGIqwFLLLWIHIDLEVLFC 226
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 387763613 280 HVMQAgiplSTGLAFLNSCLNPILYVLISKKFQARFRSSVAEILKYTLWEVS 331
Cdd:cd15106  227 HVYLV----SVVLSCLNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDIP 274
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
43-315 4.01e-11

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 63.28  E-value: 4.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQL-- 119
Cdd:cd14996    5 IIYSFLFVTGVFGNLLSLWvFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKGFYWKYQSTQCRIANFFGTLvi 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 120 --NMFASVFFLTVISLDHYIHLI------------------HPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTV 179
Cdd:cd14996   85 hvSMCVSILILSWIAISRYATLMkhdsatqkqscyekifygHFLKRFRQPKFARYLCIYIWGVVLCIIIPVVVYYSVREA 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 180 EFNNHTLCYNNFQKHDPDLTLIrhHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKK-----RSILISSRHFWTILVVVVA 254
Cdd:cd14996  165 DEDGESLCYNRQVELGAKGSQI--AGLIATTFFFLFFLVVLLSYYSFVNHLRRIQKntcisEKDLIYRSVKRNILIIQAL 242
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 387763613 255 FVVCWTPYHLFSIWELTIhHNSYSHHVMQAGIPLS---TGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd14996  243 LVVCFLPYHIFKPVFYVL-HQREDCQQLNYLIETKnilTCLASARSSTDPIMYLLLDKTFKKTL 305
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
43-312 4.17e-11

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 62.94  E-value: 4.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15149    5 VFYSLVFIVGILLNGVNFWIFFYVPSNKSFIVYLKNIVFADLLMSLTFPFKILSDVELGPWQLNVIVCRYSAVIFYLNMY 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRD-TVEFNNHTLCYNnfqkhdpdltLI 201
Cdd:cd15149   85 VGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVPNIILTNqSFHEANYTKCAR----------LK 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWVKfIIGYLFPLLTMSICYLCLIFKVK-KRSILISSRHFW------------TILVVVVAFVVCWTPYHL---- 264
Cdd:cd15149  155 SELGIQWHK-ASNYICVSIFWVVFLLLIIFYVAiSRKIYKSNQKFRrnstnmkakssrNIFSILFVFFVCFVPYHAlrip 233
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 387763613 265 FSIWELTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15149  234 YTLSQTGADYSCQSKTILYYMKEFTLLLSAANVCLDPIIYFFLCQPFR 281
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
49-311 6.67e-11

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 62.51  E-value: 6.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  49 FVLGIPGNAIVIWFTG-FKWKKTVTTLWFLNLAIADFIFLLF--LPLYISYVAMNFHWPfgIWLCKANSFTAQLNMFASV 125
Cdd:cd15386   11 LVVATAGNLAVLLAMYrMRRKMSRMHLFVLHLALTDLVVALFqvLPQLIWEITYRFQGP--DLLCRAVKYLQVLSMFAST 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 126 FFLTVISLDHYIHLIHPVLSHRHRTlKNSLIVIIFIWLLASLIGGPALY---FRDTVEFNNHTLCYNNFqkhdpDLTLIR 202
Cdd:cd15386   89 YMLIMMTVDRYIAVCHPLRTLQQPS-RQAYLMIGATWLLSCILSLPQVFifsLREVDQGSGVLDCWADF-----GFPWGA 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 203 HHVLTWVKFIIgYLFPLLTMSICY------LCLIFKVKKRSILISSRHFWTILV-----------------------VVV 253
Cdd:cd15386  163 KAYITWTTLSI-FVLPVAILIVCYslicyeICKNLKGKTQTSRSEGGGWRTQGMpsrvssvrtisrakirtvkmtfvIVL 241
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 387763613 254 AFVVCWTPY---HLFSIWELtihhNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKF 311
Cdd:cd15386  242 AYIACWAPFfsvQMWSVWDE----NAPDEDSSDFAFTITMLLASLSSCCNPWIYMFFSGHL 298
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
50-312 6.67e-11

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 62.06  E-value: 6.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  50 VLGIPGNAIVI-WFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFtaqLNMF---ASV 125
Cdd:cd15073   12 IISTISNGIVLvTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAF---LNIFfgmASI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 126 FFLTVISLDHYIHLIHPVLsHRHRTLKNSLIVII------FIWLLASLIGGpALYFRDTvefnNHTLCYNNFQKHDPDLT 199
Cdd:cd15073   89 GLLTVVAVDRYLTICRPDL-GRKMTTNTYTVMILlawtnaFFWAAMPLVGW-ASYALDP----TGATCTINWRKNDSSFV 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 lirhhVLTWVKFIIGYLFPLLTMSICYL---CLIFKVKKRSILISSRHFWT--------ILVVVVAFVVCWTPYHLFSIW 268
Cdd:cd15073  163 -----SYTMSVIVVNFIVPLAVMFYCYYnvsRFVKKVLASDCLESVNIDWTdqndvtkmSVIMIVMFLVAWSPYSIVCLW 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 387763613 269 eLTIHHNSYSHHVMQAGIPLstgLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15073  238 -ASFGEPKKIPPWMAIIPPL---FAKSSTFYNPCIYVIANKKFR 277
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
53-315 6.77e-11

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 61.97  E-value: 6.77e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  53 IPGNAIV-IWFTGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNfHWPFGIWLCKANSFTAQLNMFASVFFLTV 130
Cdd:cd15300   15 IVGNVLVmISFKVNSQLKTVNNYYLLSLACADLIIGIFsMNLYTSYILMG-YWALGSLACDLWLALDYVASNASVMNLLV 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 131 ISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALyfrdtvefnnhtLCYNNF------QKHDPDLTLIRHH 204
Cdd:cd15300   94 ISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPI------------LCWQYFvgkrtvPERECQIQFLSEP 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 205 VLTWVKFIIGYLFPLLTMSICYlCLIFK--VKKRsilissRHFWTILVVVVAFVVCWTPYHLfsiweLTIHHNSYSHHVM 282
Cdd:cd15300  162 TITFGTAIAAFYIPVSVMTILY-CRIYKetIKER------KAAQTLSAILLAFIITWTPYNI-----MVLVSTFCSDCIP 229
                        250       260       270
                 ....*....|....*....|....*....|...
gi 387763613 283 QAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15300  230 LTLWHLGYWLCYVNSTVNPMCYALCNKTFRKTF 262
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
42-313 7.16e-11

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 61.73  E-value: 7.16e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYIsyvAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15163    4 MVINTLIFLVGIVLNSLALYVFCFRTKtKTTSVIYTINLVVTDLLVGLSLPTRI---VMYYSAGNCLTCSFVHIFSYFVN 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALyfrdTVEFNNHTLCynnfqkhdpdltL 200
Cdd:cd15163   81 MYCSILFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWLFAIVVTFSIL----TTAIKFASCC------------L 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRHHVLTwvkfIIGYLFPLLTMSICYLCLIFKVKKRSILISSRH-----FWTILVVVVAFVVCWTPYHLFSIweLTIHHN 275
Cdd:cd15163  145 SKLFALT----VFEFFLPLLIITFFTIRIMCALSRPGLMHQSRErrmraVQLLITVLIIFMICFTPFHVRQV--AVAFNP 218
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 387763613 276 SYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQA 313
Cdd:cd15163  219 DIPHHTSLIVYHVTVTLSSLNSCMDPIVYCFVTNNFQS 256
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
42-312 1.00e-10

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 61.77  E-value: 1.00e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAFVLGIPGNAIVIwFTGFKWKKT--VTTLWFLNLAIAD-FIFLLFLPLYISYVAMNfHWPFGIWLCKANSFTAQ 118
Cdd:cd15396    4 IIAYSVVTIVGLFGNLCLI-TIIKKQKEEhnVTNILIANLSLSDvLVCVMCIPFTAVYTLMD-HWIFGETMCKLTSFVQS 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPvlSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRD-TVEFNNHTLCYNNFQKHD-- 195
Cdd:cd15396   82 VSVSVSIFSLVLIAIERYQLIVNP--RGWKPSASHAYWGIVLIWLFSLMISIPFLIFHQlTDEPFRNLSSHSDFYKDKvv 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 196 -----PDLTliRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILI------------SSRHFWTILVVVVAFVVC 258
Cdd:cd15396  160 cieawPSET--ERLIFTTSLLVFQYFVPLGFIFICYLKIFVCLKKRNSKIdrmrenesrlseNKRINTMLISIVVTFAAC 237
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 387763613 259 WTPYHLFSI---WE----LTIHHNsyshhvmqAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15396  238 WLPLNIFNVvfdWNhevlMSCHHN--------LVFTLCHLVAMVSTCINPIFYGFLNKNFQ 290
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
36-315 1.22e-10

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 61.58  E-value: 1.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  36 VVHWVSLVLYCLAFVLGipgNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIF-LLFLPLYISYVAMNfHWPFGIWLCkaN 113
Cdd:cd15051    1 IVLGVVLAVIILLTVIG---NVLVCLAVAVNRRlRNLTNYFIVSLAVTDLLLgLLVLPFSAIYELRG-EWPLGPVFC--N 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 114 SFTAQLNMF--ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGG-PALYFRDTVEFNNHtlcyNN 190
Cdd:cd15051   75 IYISLDVMLctASILNLFAISLDRYLAITAPLRYPSRVTPRRVAIALAAIWVVSLAVSFlPIHLGWNTPDGRVQ----NG 150
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 191 FQKHDPDLTLIRHHVLtwVKFIIGYLFPLLTMSICYLClIFKV--------KKRSILISSRHFWTILVV----------- 251
Cdd:cd15051  151 DTPNQCRFELNPPYVL--LVAIGTFYLPLLIMCGVYLR-IFRIareqakriNALTPASTANSSKSAATArehkatvtlaa 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 387763613 252 -VVAFVVCWTPYhlFSIWELT----IHHNSYSHHVMqagiplsTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15051  228 vLGAFIICWFPY--FTYFTYRglcgDNINETALSVV-------LWLGYANSALNPILYAFLNRDFRRAF 287
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
50-315 3.10e-10

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 60.14  E-value: 3.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  50 VLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFF 127
Cdd:cd15302   12 IITVIGNILVLLsFYVDRNIRQPSNYFIASLAVSDLLIGLEsMPFYTVYVLNGDYWPLGWVLCDLWLSVDYTVCLVSIYT 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 128 LTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPAL----YFRDTVEFNNHTLCYNNFQKhDPDLTLIrh 203
Cdd:cd15302   92 VLLITIDRYCSVKIPAKYRNWRTPRKVLLIIAITWIIPALLFFISIfgwqYFTGQGRSLPEGECYVQFMT-DPYFNMG-- 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 204 hvltwvkFIIGYLFPLLTMSICYLCLIFKVKKRSilisSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYSHHVMQ 283
Cdd:cd15302  169 -------MYIGYYWTTLIVMLILYAGIYRAANRA----RKALRTITFILGAFVICWTPYHILATIYGFCEAPPCVNETLY 237
                        250       260       270
                 ....*....|....*....|....*....|..
gi 387763613 284 AgipLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15302  238 T---ISYYLCYMNSPINPFCYALANQQFKKTF 266
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
69-315 3.38e-10

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 59.98  E-value: 3.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  69 KTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNfHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHR 147
Cdd:cd17790   32 KTVNNYFLLSLACADLIIGAFsMNLYTTYILMG-HWALGTVACDLWLALDYVASNASVMNLLIISFDRYFSITRPLTYRA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 148 HRTLKNSLIVIIFIWLLASLIGGPALYF------RDTVEFNNhtlCYNNFqkhdpdltlIRHHVLTWVKFIIGYLFPLLT 221
Cdd:cd17790  111 KRTPRRAAIMIGLAWLISFVLWAPAILFwqylvgERTVLAGQ---CYIQF---------LSQPIITFGTAIAAFYLPVTI 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 222 MSICYLCL---IFKVKKRSILISSRHFWTILVvvvafvvcWTPYHLfsiweLTIHHNSYSHHVMQAGIPLSTGLAFLNSC 298
Cdd:cd17790  179 MIILYWRIyreTIKEKKAARTLSAILLAFILT--------WTPYNI-----MVLVSTFCKDCVPKTLWELGYWLCYVNST 245
                        250
                 ....*....|....*..
gi 387763613 299 LNPILYVLISKKFQARF 315
Cdd:cd17790  246 VNPMCYALCNKSFRDTF 262
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
40-267 3.45e-10

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 60.22  E-value: 3.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVL-YCLAFVLGIPGNAIVIWFT-GFKWKKTVTTLWFLNLAIADFIF-LLFLPLYISYVAMNfHWPFGIWLCKANSFT 116
Cdd:cd15399    1 IVLILaYCSIILLGVVGNSLVIYVViKFKNMRTVTNFFIANLAVADLMVnTLCLPFTLVYTLLD-EWKFGAVLCHLVPYA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 117 AQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRtlKNSLIVIIFIWLLASLIGGPALYFRD--TVEFNNHTLCYNNFQKH 194
Cdd:cd15399   80 QALAVHVSTVTLTVIALDRHRCIVYHLESKISK--KISFLIIGLTWAASALLASPLAIFREysVIEISPDFKIQACSEKW 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 195 dPDLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKK-------RSILISSRHFWT--ILVVVVAFVVCWTPYHLF 265
Cdd:cd15399  158 -PNGTLNDGTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNhvspgggNDHYHQRRRKTTkmLVCVVVVFAVSWLPFHAF 236

                 ..
gi 387763613 266 SI 267
Cdd:cd15399  237 QL 238
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
69-315 3.94e-10

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 59.75  E-value: 3.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  69 KTVTTLWFLNLAIADFIF-LLFLPLYISYVaMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHR 147
Cdd:cd15050   32 HTVGNLYIVSLSVADLIVgAVVMPLNIVYL-LESKWILGRPVCLFWLSMDYVASTASIFSLFILCIDRYRSVQQPLKYLK 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 148 HRTLKNSLIVIIFIWLLASL----IGGPALYFRDTVEFNNHTLCYNNFqkhdpdltlirhHVLTWVKF---IIGYLFPLL 220
Cdd:cd15050  111 YRTKTRASLMISGAWLLSFLwvipILGWHHFARGGERVVLEDKCETDF------------HDVTWFKVltaILNFYIPSL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 221 TMsICYLCLIFKVKKRSiLISSRHFWTILvvvVAFVVCWTPYHLFSIwELTIHHNSYSHHVMQAGIplstGLAFLNSCLN 300
Cdd:cd15050  179 LM-LWFYAKIFKAVNRE-RKAAKQLGFIM---AAFILCWIPYFILFM-VIAFCKNCCNENLHMFTI----WLGYINSTLN 248
                        250
                 ....*....|....*
gi 387763613 301 PILYVLISKKFQARF 315
Cdd:cd15050  249 PFIYPLCNENFKKTF 263
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
38-315 4.33e-10

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 59.56  E-value: 4.33e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  38 HWVSLvLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFL-NLAIADFIF-LLFLPLYISYVAMNFHWPFGIWLCKANSF 115
Cdd:cd15304    1 NWPAL-LTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLmSLAIADMLLgFLVMPVSMLTILYGYRWPLPSKLCAVWIY 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 116 TAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFrdtvEFNNHTLCYnnfqkhD 195
Cdd:cd15304   80 LDVLFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVF----GLQDDSKVF------K 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 196 PDLTLIRHHVLTWVKFIIGYLFPLLTMSICYLcLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIWELtIHHN 275
Cdd:cd15304  150 EGSCLLADENFVLIGSFVAFFIPLTIMVITYF-LTIKSLQQSISNEQKASKVLGIVFFLFVVMWCPFFITNVMAV-ICKE 227
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 387763613 276 SYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15304  228 SCNEVVIGGLLNVFVWIGYLSSAVNPLVYTLFNKTYRSAF 267
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
50-315 4.45e-10

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 59.92  E-value: 4.45e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  50 VLGIPGNAIVIwFTGFKWKK--TVTTLWFLNLAIADFIFLLF-LPLYISYVamnFH--WPFGIWLCKANSFTAQLNMFAS 124
Cdd:cd15402   12 VVDILGNLLVI-LSVYRNKKlrNAGNIFVVSLAVADLVVAIYpYPLVLTSI---FHngWNLGYLHCQISGFLMGLSVIGS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 125 VFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALyFRDTVEFNNHTLCYNNFQKHDPDLTLirhh 204
Cdd:cd15402   88 IFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPNL-FVGSLQYDPRIYSCTFAQSVSSAYTI---- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 205 vltwVKFIIGYLFPLLTMSICYL---CLIFKVKKRSILISS--------RHFWTILVVVVAFVVCWTPYHLFSIwELTIH 273
Cdd:cd15402  163 ----AVVFFHFILPIIIVTFCYLriwILVIQVRRRVKPDNKpklkphdfRNFVTMFVVFVLFAVCWAPLNFIGL-AVAVD 237
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 387763613 274 HNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15402  238 PETIVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRREY 279
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
44-315 7.36e-10

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 59.00  E-value: 7.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15167    6 FYYLIFLIGFIGSCFALWaFIQKRSSRKCINIYLINLLTADFLLTLALPVKIAVDLGIAPWKLKIFHCQVTACLIYINMY 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFrdtvefnnhtlcynnfqkhdPDLTLIR 202
Cdd:cd15167   86 LSIIFLGFVSIDRYLQLTHSSKLYRIQEPGFAKMISAVVWTLVLFIMVPNMAI--------------------PIKTIEE 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 203 HHVLTWVKF--IIGYLFPLLTMSICylCLIFKVKKRSILISS----RHFW----------------TILVVVVAFVVCWT 260
Cdd:cd15167  146 KPGVGCADFktEFGRHWHVLTNFIC--MAIFLNFSAIILISNflviRKLYrnkdseeyrnarqalvNILLVTAGYVICFV 223
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 387763613 261 PYHLFSIWELTIHHNSYSHHVMQAGIPLSTG----LAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15167  224 PYHIVRIPYTLSQSEVITDCSLKRSLFLAKEstllLAVLNLCFDPILYFHLSKAFRSKI 282
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
38-317 7.51e-10

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 59.15  E-value: 7.51e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  38 HWVSLvLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIF-LLFLPLYISYVAMNFHWPFGIWLCKANSF 115
Cdd:cd15305    1 NWPAL-LILIIIILTIGGNILVIMAVSLEKKlQNATNFFLMSLAVADMLVgILVMPVSLIAILYDYAWPLPRYLCPIWIS 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 116 TAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGG--PALYFRDTVEFNNHTLCYNNfqk 193
Cdd:cd15305   80 LDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMpiPVIGLQDDEKVFVNGTCVLN--- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 194 hDPDLTLIRhhvlTWVKFIIgylfPLLTMSICYLCLIFKVKKRSILISSRHFWTIL-VVVVAFVVCWTPYHLFSIWELtI 272
Cdd:cd15305  157 -DENFVLIG----SFVAFFI----PLIIMVITYCLTIQVLQRQQAINNERRASKVLgIVFFLFLIMWCPFFITNILSV-L 226
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 387763613 273 HHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARFRS 317
Cdd:cd15305  227 CKEACDQKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYRRAFSN 271
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
49-308 8.43e-10

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 59.06  E-value: 8.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  49 FVLGIPGNAIVIWFTGFKWKKTVTTLWFL-NLAIADFIFLLF--LPLYISYVAMNFHWPfgIWLCKANSFTAQLNMFASV 125
Cdd:cd15385   11 FAVAVIGNSSVLLALYKTKKKASRMHLFIkHLSLADLVVAFFqvLPQLCWDITYRFYGP--DFLCRIVKHLQVLGMFAST 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 126 FFLTVISLDHYIHLIHPvLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTL---CYNNFQKHDPdltlIR 202
Cdd:cd15385   89 YMLVMMTADRYIAICHP-LKTLQQPTKRSYLMIGSAWALSFILSTPQYFIFSLSEIENGSGvydCWANFIVPWG----IK 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 203 HHVlTWVKFIIgYLFPLLTMSICYLCLIF-----------------KVKKRSILISSRHFWTI-----------LVVVVA 254
Cdd:cd15385  164 AYI-TWITISI-FVVPVIILLTCYGFICYniwrnikcktrrglsdnALKNILLAVCVSSVKTIsrakirtvkmtFVIVLA 241
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 387763613 255 FVVCWTPYHLFSIWELTIHHNSYSHHVmQAGIPLSTGLAFLNSCLNPILYVLIS 308
Cdd:cd15385  242 YIVCWAPFFTIQMWSVWDQNFPWDESE-NTAVTITALLASLNSCCNPWIYMFFS 294
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
42-315 8.78e-10

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 59.07  E-value: 8.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAFVLGIPGNAIV-IWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15981    4 ILAYLFIFLLCMVGNGLVcFIVLKNRQMRTVTNMFILNLAVSDLLVGIFCMPTTLVDNLITGWPFDNAMCKMSGLVQGMS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVlsHRHRTLKNSLIVIIFIWLLASLIGGPALY--------FRDTVEFNNHTLCYNNFQ 192
Cdd:cd15981   84 VSASVFTLVAIAVERFRCIVHPF--RQKLTLRKAIVTIVIIWVLALIIMCPSAVtltvtreeHHFMVDDYNNSYPLYSCW 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 193 KHDPDLTLIRhhVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRH----------------FWTILVVVVAFV 256
Cdd:cd15981  162 EAWPDTEMRK--IYTTVLFSHIYLAPLTLIVIMYARIAFKLFKSSAPIRGSQgeeeegrrvskrkikvINMLIIVALFFT 239
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 387763613 257 VCWTPyhlfsIWELTI-----HHNSYSHHVMQAGI-PLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15981  240 LSWLP-----LWTLMLltdygHLSEDQLNLVTVYVfPFAHWLAFFNSSVNPIIYGYFNENFRRGF 299
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
79-315 9.84e-10

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 58.49  E-value: 9.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  79 LAIAD-FIFLLFLPLYISYVAMNfHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIV 157
Cdd:cd15064   42 LAVADlLVAVLVMPLSAVYELTG-RWILGQVLCDIWISLDVTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVM 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 158 IIFIWLLASLIGGPALYFRDTVefnnhtlcynnfQKHDPDLTLI-RHHVLTWVKFIIGYLFPLLTMSICYlCLIFKVKKR 236
Cdd:cd15064  121 IALVWTLSICISLPPLFGWRTP------------DSEDPSECLIsQDIGYTIFSTFGAFYIPLLLMLILY-WKIYRAAAR 187
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 387763613 237 siliSSRHFWTILVVVVAFVVCWTPyhlFSIWELTIHHNSYShHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15064  188 ----ERKAAKTLGIILGAFIVCWLP---FFLVALIVPLCSHC-WIPLALKSFFLWLGYFNSLINPLIYTFFNKDFRKAF 258
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
49-315 1.18e-09

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 58.45  E-value: 1.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  49 FVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIF-LLFLPLYISYVAMNfHWPFGIWLCKANSFTAQLNMFASVF 126
Cdd:cd15330   11 ILCAIFGNACVVAAIALERSlQNVANYLIGSLAVTDLMVsVLVLPMAALYQVLN-KWTLGQVTCDLFIALDVLCCTSSIL 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 127 FLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEfnnhtlcynnfQKHDPDLTLI-RHHV 205
Cdd:cd15330   90 HLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWRTPE-----------DRSDPDACTIsKDPG 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 206 LTWVKFIIGYLFPLLTMSICYlCLIFKVKKRSilisSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYSHHVMQAG 285
Cdd:cd15330  159 YTIYSTFGAFYIPLILMLVLY-GRIFKAAARE----RKTVKTLGIIMGTFILCWLPFFIVALVLPFCESTCHMPELLGAI 233
                        250       260       270
                 ....*....|....*....|....*....|
gi 387763613 286 IplsTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15330  234 I---NWLGYSNSLLNPIIYAYFNKDFQSAF 260
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
50-315 1.46e-09

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 58.21  E-value: 1.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  50 VLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFL 128
Cdd:cd15000   11 LFGIFGNFVLLYiLASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSLLLASVLAL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 129 TVISLDhyiHLIHPVLSHRHRTLKNSL-IVIIFIWLLASLIGGPALYFRDTVEFN----NHTLCYNNFQkhdpdLTLIRH 203
Cdd:cd15000   91 CAVSYD---RLTAIVLPSEARLTKRGAkIVIVITWIVGLLLALPLAIYRSYRERQwknfLETYCAENTQ-----VLPIYW 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 204 HVltwvkfIIGYL--FPLLTMSICYLCLIFKVKK--RSILISSRHFW---------TILVVVVAFVVCWTPYHLFSIWEL 270
Cdd:cd15000  163 HV------IITVLvwLPLGIMLICYSAIFWKLDKyeRRVLRREHPSVvrykkkaakTLFIVLITFVVCRIPFTALIFYRY 236
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 387763613 271 TIHHNSYSHHVMQAGIPL----STGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15000  237 KLVPNDNTQNSVSGSFHIlwfaSKYLMFLNAAVNPLIYGFTNENFRKAF 285
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
43-315 1.65e-09

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 58.00  E-value: 1.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIwFTGFKWKK--TVTTLWFLNLAIADFIFLLF-LPLYISYVAMNfHWPFGIWLCKANSFTAQL 119
Cdd:cd15401    5 GVLIFTIVVDVLGNLLVI-LSVLRNKKlrNAGNIFVVSLSVADLVVAVYpYPLILLAIFHN-GWTLGNIHCQISGFLMGL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 120 NMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLaSLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLT 199
Cdd:cd15401   83 SVIGSVFNITAIAINRYCYICHSLRYDKLYNMKKTCCYVCLTWVL-TLAAIVPNFFVGSLQYDPRIYSCTFAQTVSSSYT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 LIrhhvltwvKFIIGYLFPLLTMSICYL---CLIFKVKKRSILISS--------RHFWTILVVVVAFVVCWTPYHLFSIw 268
Cdd:cd15401  162 IT--------VVVVHFIVPLSIVTFCYLriwVLVIQVKHRVRQDSKqklkandiRNFLTMFVVFVLFAVCWGPLNFIGL- 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 387763613 269 ELTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15401  233 AVAINPLKVAPKIPEWLFVLSYFMAYFNSCLNAVIYGVLNQNFRKEY 279
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
55-315 1.68e-09

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 57.98  E-value: 1.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  55 GNAIVIWFTGF-KWKKTVTTLWFLNLAIADFIFLLFLpLYISYVAMNFHWPFGI--------WLCKANSFTAQLNMFASV 125
Cdd:cd15137   17 GNLFVLIWRLKyKEENKVHSFLIKNLAIADFLMGVYL-LIIASVDLYYRGVYIKhdeewrssWLCTFAGFLATLSSEVSV 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 126 FFLTVISLDHYIHLIHPvLSHRHRTLKNSLIVIIFIWLLASLIGG-PALYFRDTVEF-NNHTLCYNnFQKHDPDLTLIRH 203
Cdd:cd15137   96 LILTLITLDRFICIVFP-FSGRRLGLRRAIIVLACIWLIGLLLAVlPLLPWDYFGNFyGRSGVCLP-LHITDERPAGWEY 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 204 HVLTwvkFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRH-----------FWTILVVVVafvvCWTPYHLFSIWELti 272
Cdd:cd15137  174 SVFV---FLGLNFLAFVFILLSYIAMFISIRRTRKAAASRKskrdmavakrfFLIVLTDFL----CWIPIIVIGILAL-- 244
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 387763613 273 hhnsyshhvmqAGIPLStGLAF---------LNSCLNPILYVLISKKFQARF 315
Cdd:cd15137  245 -----------SGVPIP-GEVYawvavfvlpINSALNPILYTLSTPKFRKKL 284
7tmA_MrgprD cd15108
mas-related G protein-coupled receptor subtype D, member of the class A family of ...
39-188 2.08e-09

mas-related G protein-coupled receptor subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320236  Cd Length: 276  Bit Score: 57.84  E-value: 2.08e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMnfhwPFGIWLCKANSFTAQ 118
Cdd:cd15108    1 EVLSALVMFTCVCGMAGNGLVVWLLSCRGRRTPFCVYVLHLAVADLLFLLCMASTLSLETS----PLVITHDLAYEVVRR 76
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 387763613 119 LNMFA---SVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCY 188
Cdd:cd15108   77 VKYFAytaSLSLLTAISTQRCLSVLFPIWYKCHQPRHLSAVVCALLWALSLLMNVLASFFCSEFWHPDEWQCF 149
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-315 2.29e-09

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 57.94  E-value: 2.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIWFT-GFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTA 117
Cdd:cd15976    1 YINTVVSCLVFVLGIIGNSTLLRIIyKNKCMRNGPNILIASLALGDLLHIIIDIPINVYKLLAEDWPFGVEMCKLVPFIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 118 QLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNH----TLCYNNFQK 193
Cdd:cd15976   81 KASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSIILAVPEAIGFDMITMDYKgellRICLLHPIQ 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 194 HDPDLTLIRHHVLTWVkFIIGYLFPLLTMSICYLCLIFKV--KKRSILIS-SRHFW-------TILVVVVAFVVCWTPYH 263
Cdd:cd15976  161 KTAFMQFYKTAKDWWL-FSFYFCLPLACTAVFYTLMTCEMlrKKNGMQIAlNDHLKqrrevakTVFCLVLVFALCWLPLH 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 387763613 264 LFSIWELTIHHNSYSHHVMQAGIPL-----STGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15976  240 LSRILKLTIYDEKDPNRCELLSFFLvldyiGINMASLNSCINPIALYLVSKRFKNCF 296
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
43-315 2.30e-09

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 57.28  E-value: 2.30e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADF-IFLLFLPLYISYVAMNfHWPFGIWLCKANSFTAQLN 120
Cdd:cd15329    5 IVLLIIILGTVVGNALVIIAVCLVKKlRTPSNYLIVSLAVSDLlVALLVMPLAIIYELSG-YWPFGEILCDVWISFDVLL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALyfrdtvefnnhtLCYNNFQKHDPDLTL 200
Cdd:cd15329   84 CTASILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIVWLLSALISIPPL------------FGWKNKVNDPGVCQV 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRHHVLTWVKFIIGYLFPLLTMSICYLcLIFKVKKRSilisSRHFWTILVVVVAFVVCWTPYHLFSIWeltihhNSYSHH 280
Cdd:cd15329  152 SQDFGYQIYATFGAFYIPLIVMLVLYY-KIYRAAKSE----RKAIKTLGIIMGAFTLCWLPFFILALL------RPFLKP 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 387763613 281 VMQAGIPLSTGLAFL-----NSCLNPILYVLISKKFQARF 315
Cdd:cd15329  221 IKCSCIPLWLSRLFLwlgyaNSFLNPIIYAKFNREFRTPF 260
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
78-310 3.71e-09

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 56.92  E-value: 3.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  78 NLAIAD------FIFLLFLPLYISYVAMNFHWPFgiwlcKANSFTaqLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTL 151
Cdd:cd14972   39 NLAAADllagiaFVFTFLSVLLVSLTPSPATWLL-----RKGSLV--LSLLASAYSLLAIAVDRYISIVHGLTYVNNVTN 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 152 KNSLIVIIFIWLLASLIGGPALYFRDTVEfNNHTLCYNNFqkhdPDLTliRHHVLTWVKFIigyLFPLLTMSICYLCLIF 231
Cdd:cd14972  112 KRVKVLIALVWVWSVLLALLPVLGWNCVL-CDQESCSPLG----PGLP--KSYLVLILVFF---FIALVIIVFLYVRIFW 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 232 KVKKRSILISSRH--------------FWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYSHHVMQAGIplstGLAFLNS 297
Cdd:cd14972  182 CLWRHANAIAARQeaavpaqpstsrklAKTVVIVLGVFLVCWLPLLILLVLDVLCPSVCDIQAVFYYFL----VLALLNS 257
                        250
                 ....*....|...
gi 387763613 298 CLNPILYVLISKK 310
Cdd:cd14972  258 AINPIIYAFRLKE 270
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
37-324 5.99e-09

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 56.26  E-value: 5.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  37 VHWVSLVLYCLAFVlgipGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLL--FLPLYISYVAMNFHWPFGIWLCKANS 114
Cdd:cd15110    3 EVWVSLIICLLGLV----GNGIVLWFLGFRIRRNPFTVYILHLAIADFTFLLciFILSIMYIGPFNFSHSRDYVAMLIFI 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 115 FTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYnnfqkh 194
Cdd:cd15110   79 ILFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAIVCGLLWALSVLMTSLEYLMCIDEGFHVRNECR------ 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 195 dpdLTLIRHHVLTWVKFIigylfPLltMSICYLCLIFKVKKRSILI-SSRHFWTILVVVVAFVVCWTPyhlFSIWELTIH 273
Cdd:cd15110  153 ---AVLIFIGILTFLVFT-----PL--MLISSLILFIKVRCNSQRRhPGKLYIIIMLTVIFFLIFAMP---MRVLLLLNY 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 387763613 274 HNSYSHHVMQagiPLSTGLAFLNSCLNPILYVLISKKFQARFRSSVAEILK 324
Cdd:cd15110  220 LHHSSFLFSN---PVPFLLSTVNSSINPIVYFLVGSLRRKRIKKSLKVALQ 267
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
39-315 7.41e-09

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 56.07  E-value: 7.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIWFT-GFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTA 117
Cdd:cd15977    1 YVNTILSCVIFLVGIIGNSTLLRIIyKNKCMRNGPNVLIASLALGDLLYILIAIPINVIKLIAEDWPFGVHVCKLYPFIQ 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 118 QLNMFASVFFLTVISLDHYihliHPVLS-HRHRTLKNSL---IVIIFIWLLASLIGGPALYFRDTVEFNNHT----LCYN 189
Cdd:cd15977   81 KASVGITVLSLCALSIDRY----RAVASwSRIRGIGIPVwkaVEVTLIWAVAIIVAVPEAIAFDMVEIDYRGqtllVCML 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 190 NFQKHDpDLTLIRHHVLTWVKFIIGYLFPLLTMSICYL---CLIFKVKKRSILISSRHF-------WTILVVVVAFVVCW 259
Cdd:cd15977  157 PMEQTS-SFMRFYQDVKDWWLFGFYFCLPLACTGVFYTlmsCEMLSIKNGMRIALNDHMkqrrevaKTVFCLVVIFALCW 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 387763613 260 TPYHLFSIWELTIHHNSYSHHVMQAGIPL-----STGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15977  236 LPLHLSRILKKTIYDVKDPQRCELLSFLLvmdytGINMASLNSCINPVALYFVSRKFKNCF 296
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
50-315 7.71e-09

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 56.21  E-value: 7.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  50 VLGIPGNAIVIW--FTGFKWKKTvTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCkaNSFTAQLNMF--ASV 125
Cdd:cd15065   11 VLAIFGNVLVCLaiFTDRRLRKK-SNLFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFC--NIWISFDVMCstASI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 126 FFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIG-----------GPALYFRDTVEFNNHTLCYNnfqkh 194
Cdd:cd15065   88 LNLCAISLDRYIHIKKPLKYERWMTTRRALVVIASVWILSALISflpihlgwhrlSQDEIKGLNHASNPKPSCAL----- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 195 dpDLTLIRHHVLTWVKFIIgylfPLLTMSICYLCLIFKVKKRSILISSRHFWTILVVVVAFV------------------ 256
Cdd:cd15065  163 --DLNPTYAVVSSLISFYI----PCLVMLLIYSRLYLYARKHVVNIKSQKLPSESGSKFQVPslsskhnnqgvsdhkaav 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 387763613 257 ----------VCWTPYHLFSIWELTIHHnSYSHHVMQAgiplSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15065  237 tlgiimgvflICWLPFFIINIIAAFCKT-CIPPKCFKI----LTWLGYFNSCLNPIIYSIFNSEFRRAF 300
7tmA_MrgprF cd15109
mas-related G protein-coupled receptor subtype F, member of the class A family of ...
42-175 9.95e-09

mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320237  Cd Length: 274  Bit Score: 55.68  E-value: 9.95e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAfvlGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15109    7 FLLLCLC---GLVGNGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVSRILGLCTF 83
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYF 175
Cdd:cd15109   84 LTGVSLLPAISIERCVSVIFPTWYWRRRPKRLSAVVCALLWMLSLLVTCIHNYF 137
7tmA_MrgprB cd15107
mas-related G protein-coupled receptor subtype B, member of the class A family of ...
50-316 1.59e-08

mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320235  Cd Length: 276  Bit Score: 55.10  E-value: 1.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  50 VLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHW-PFGIWLCKANSFTaqLNMFASVFFL 128
Cdd:cd15107   12 LVGLAGNAIVLWLLGFHMHRNAFSVYILNLAGADFLFLCTQIVFSLEIVLQFHSiDIHIPLFLLTVTM--FAYLAGLSMI 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 129 TVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGgpalyfrdtveFNNHTLCYNNFQKHDPDLTLIrhhvltw 208
Cdd:cd15107   90 TAISIERCLSVMWPIWYHCQRPRHTSAVICTLLWVLSLLLS-----------LLEGKGCGFLFSTYDYYWCWT------- 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 209 VKFIIGYLFPLLTMSIC--YLCLIFKVKKRSILIS-SRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSY--SHHVMQ 283
Cdd:cd15107  152 LDLITTAWLIVLFVVLSgsSLALLVRIFCGSHRIPvTRLYVTIALTVLVFLIFGLPFGIYWFLLKWIEEFYIvpCCGFYE 231
                        250       260       270
                 ....*....|....*....|....*....|...
gi 387763613 284 AGIPLStglaFLNSCLNPILYVLISKKFQARFR 316
Cdd:cd15107  232 VILFLS----CVNSCANPIIYFLVGSIRHHRFQ 260
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
44-314 1.74e-08

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 54.84  E-value: 1.74e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISyvAMNFHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15171    6 LCSAVFLVGLLDNGLVVFiLVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAH--AAWHGGSLGNPTCKVLVALSSVGLH 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 123 ASVFFLTVISLDHYIHLIHP-VLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLI 201
Cdd:cd15171   84 SEALFNVLLTVQASRVFFHGrLASSARRVAPCGIIASVLAWLTAFLVTLPEFVFYKPQMDSQKSKCAFSRPHFLPAEETF 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWVKFIIGYLFPLLTMSICYLCLifKVKKRSILISSRHFWTILVVVVAFVVCWTPYH----LFSIWELTIHHNSY 277
Cdd:cd15171  164 WKYFLTLKMNIVVLVFPLLVFIICCVQL--RKTQRFRERQRDLSKLVFAIMVVFLLMWAPYNialfLSAFKEHFSLRDCK 241
                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 387763613 278 SHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd15171  242 SSYHLDASVQVTKLIATTHCCVNPLLYALLDPAFRRR 278
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
50-235 2.15e-08

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 54.72  E-value: 2.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  50 VLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFL 128
Cdd:cd15336   12 ITGMLGNALVIYaFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSMITL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 129 TVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWL------LASLIGGPALyfrdtVEFNNHTLCYNNFQKHDPDltlir 202
Cdd:cd15336   92 LAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLyslawsLPPLFGWSAY-----VPEGLLTSCTWDYMTFTPS----- 161
                        170       180       190
                 ....*....|....*....|....*....|...
gi 387763613 203 HHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKK 235
Cdd:cd15336  162 VRAYTMLLFCFVFFIPLGIIIYCYLFIFLAIRS 194
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
69-315 2.15e-08

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 54.59  E-value: 2.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  69 KTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNfHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHR 147
Cdd:cd15297   32 QTVNNYFLFSLACADLIIGVFsMNLYTLYTVIG-YWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPV 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 148 HRTLKNSLIVIIFIWLLASLIGGPALYFRD------TVEFNNhtlCYNNFqkhdpdltlIRHHVLTWVKFIIGYLFPLLT 221
Cdd:cd15297  111 KRTTKMAGMMIAAAWVLSFILWAPAILFWQfivggrTVPEGE---CYIQF---------FSNAAVTFGTAIAAFYLPVII 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 222 MSICYLcLIFKVKKRSILISSrhfwTILVVVVAFVVCWTPYHLfsiweLTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNP 301
Cdd:cd15297  179 MTVLYW-QISRASSREKKVTR----TILAILLAFIITWTPYNV-----MVLINTFCASCIPNTVWTIGYWLCYINSTINP 248
                        250
                 ....*....|....
gi 387763613 302 ILYVLISKKFQARF 315
Cdd:cd15297  249 ACYALCNATFKKTF 262
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-308 2.53e-08

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 54.44  E-value: 2.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFL-NLAIADFIFLLF--LPLYISYVAMNFHWPfgIWLCKANSFT 116
Cdd:cd15387    2 VEVTVLALILFLALTGNICVLLAIHTTRHKHSRMYFFMkHLSIADLVVAVFqvLPQLIWDITFRFYGP--DFLCRLVKYL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 117 AQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTlknSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTL-CYNNF-QKH 194
Cdd:cd15387   80 QVVGMFASTYMLLLMSIDRCLAICQPLRSLHRRS---DRVYVLFSWLLSLVFSIPQVHIFSLREVGNGVYdCWADFiQPW 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 195 DPDLtlirhhVLTWVKFIIgYLFPLLTMSICYLCLIFKV--------------------KKRSI--------LISSRHFW 246
Cdd:cd15387  157 GPKA------YITWITLSV-YIIPVLILSVCYGLISFKIwqnvklktrretktplssaaSGGAAlarvssvkLISKAKIR 229
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 387763613 247 TI---LVVVVAFVVCWTPYHLFSIWeltihhNSYSHHVMQAGIP--LSTGLAFLNSCLNPILYVLIS 308
Cdd:cd15387  230 TVkmtFVIVLAYIVCWTPFFFVQMW------SVWDPNAPKEASPfiIAMLLASLNSCCNPWIYMFFT 290
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
49-312 3.63e-08

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 53.76  E-value: 3.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  49 FVLGIPGNAIV-IWFTGFKWKKTVTTLWFLNLAIADF---IFLLFLPLYISYVAMNFH-----WPFGIWlCKANSFTAQL 119
Cdd:cd15136   11 FLLALVGNIIVlLVLLTSRTKLTVPRFLMCNLAFADFcmgIYLGLLAIVDAKTLGEYYnyaidWQTGAG-CKTAGFLAVF 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 120 NMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALyfrdtVEFNNHT---LCYnNFQKHDP 196
Cdd:cd15136   90 SSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMALLPL-----VGVSSYSktsICL-PFETETP 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 dltlirhHVLTWVKFIIGY-LFPLLTMSICYLClIFKVKKRSILISSRHFWTI----LVVVVAFVVCWTPYHLFSIWELt 271
Cdd:cd15136  164 -------VSKAYVIFLLLFnGLAFLIICGCYIK-IYLSVRGSGRAANSNDTRIakrmALLVFTDFLCWAPIAFFGLTAA- 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 387763613 272 ihhnsyshhvmqAGIPLSTG------LAF---LNSCLNPILYVLISKKFQ 312
Cdd:cd15136  235 ------------FGLPLISVsnakilLVFfypLNSCANPFLYAIFTKQFR 272
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
69-315 4.12e-08

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 53.69  E-value: 4.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  69 KTVTTLWFLNLAIADFIF-LLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHR 147
Cdd:cd15308   32 KTTTNYFIVSLAVADLLLaLLVLPLYVYSEFQGGVWTLSPVLCDALMTMDVMLCTASIFNLCAISVDRFIAVSVPLNYNR 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 148 HRTLKNSLIVIIFIWLLASLIGGPALYfrdtvefnnhtlCYNNFQKHDPDLTLIRHHVLTWVKFIIGYLFPLLTMSICYl 227
Cdd:cd15308  112 RQGSVRQLLLISATWILSFAVASPVIF------------GLNNVPNRDPAVCKLEDNNYVVYSSVCSFFIPCPVMLVLY- 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 228 CLIFKVKKRsiliSSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHhnsySHHVMQAGIPLSTGLAFLNSCLNPILYVLI 307
Cdd:cd15308  179 CAMFRGLGR----ERKAMRVLPVVVGAFLFCWTPFFVVHITRALCE----SCSIPPQLISIVTWLGYVNSALNPVIYTVF 250

                 ....*...
gi 387763613 308 SKKFQARF 315
Cdd:cd15308  251 NAEFRNVF 258
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
40-315 5.47e-08

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 53.42  E-value: 5.47e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGN-AIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQ 118
Cdd:cd15125    2 VIPSLYLLIITVGLLGNiTLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFN-----NHTLC--YNNF 191
Cdd:cd15125   82 TSVGVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFSEVAHIMpddntTFTACipYPQT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 192 QKHDPDLtlirHHVLTwvkFIIGYLFPLLTMSICYLCL--------------IFKVKKRSILISSRHFWTILVVVVAFVV 257
Cdd:cd15125  162 DEMHPKI----HSVLI---FLVYFLIPLAIISIYYYHIaktliksahnipgeYSEHSKRQMETRKRLAKIVLVFVGLFAF 234
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 387763613 258 CWTPYHLFSIWElTIHHNSYSHHVMQAGIPL-STGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15125  235 CWFPNHVLYMYR-SFNYNEIDSSLGHMIVTLvARVLSFCNSCVNPFALYLLSESFRRHF 292
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
41-308 5.79e-08

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 53.20  E-value: 5.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  41 SLVLYCLAFVLGIPGNAIVIWFTGFKWKK-TVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQL 119
Cdd:cd14964    1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRpRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 120 NMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRdTVEFNNHTLCYNNFqkhdpdlT 199
Cdd:cd14964   81 ANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGK-GAIPRYNTLTGSCY-------L 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 LIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRH----------FWTILVVVVAFVVCWTPYHLFSIwE 269
Cdd:cd14964  153 ICTTIYLTWGFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAAslntdknlkaTKSLLILVITFLLCWLPFSIVFI-L 231
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 387763613 270 LTIHHNSYSHHVMqagIPLSTGLAFLNSCLNPILYVLIS 308
Cdd:cd14964  232 HALVAAGQGLNLL---SILANLLAVLASTLNPFIYCLGN 267
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
50-315 5.93e-08

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 53.11  E-value: 5.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  50 VLGIPGNAIVIWFTGFKWKKTVTTLWFL-NLAIADFIF-LLFLPLYISYVAMNFhWPFGIWLCKANSFTAQLNMFASVFF 127
Cdd:cd15059   12 LLIIVGNVLVIVAVLTSRKLRAPQNWFLvSLAVADILVgLLIMPFSLVNELMGY-WYFGSVWCEIWLALDVLFCTASIVN 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 128 LTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPAL-YFRDTvefnnhtlcynnfQKHDPDLTLIRHHVL 206
Cdd:cd15059   91 LCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLfGWKDE-------------QPWHGAEPQCELSDD 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 207 TWVKF--IIGYLF-PLLTMSICYLCLIFKVKKRsilisSRHFWTIL-VVVVAFVVCWTPYhlFSIWELTIHhnSYSHHVM 282
Cdd:cd15059  158 PGYVLfsSIGSFYiPLLIMIIVYARIYRAAKRK-----ERRFTLVLgVVMGAFVLCWLPF--FFTYPLVVV--CKTCGVP 228
                        250       260       270
                 ....*....|....*....|....*....|...
gi 387763613 283 QAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15059  229 ELLFKFFFWLGYCNSALNPVIYTIFNKDFRRAF 261
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
42-319 9.01e-08

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 52.94  E-value: 9.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADF-IFLLFLPLYISYVaMNFHWPFGIWLCKANSFTAQL 119
Cdd:cd15055    4 YIVLSSISLLTVLGNLLVIIsISHFKQLHTPTNLLLLSLAVADFlVGLLVMPFSMIRS-IETCWYFGDTFCKLHSSLDYI 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 120 NMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVE-FNNHTLCYNnfqkhdpDL 198
Cdd:cd15055   83 LTSASIFNLVLIAIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSVLLYDNLNQPgLIRYNSCYG-------EC 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 TLIRHHVLTWVKFIIGYLFPLLTMSICYLcLIFKVKKRSI-LISSRHFWTILVVVVAFVV-------------------- 257
Cdd:cd15055  156 VVVVNFIWGVVDLVLTFILPCTVMIVLYM-RIFVVARSQArAIRSHTAQVSLEGSSKKVSkkserkaaktlgivvgvfll 234
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 387763613 258 CWTPYHLFSIWELTIHHNSYShhvmqagIPLSTGLAFLNSCLNPILYVLiskkFQARFRSSV 319
Cdd:cd15055  235 CWLPYYIVSLVDPYISTPSSV-------FDVLIWLGYFNSCLNPLIYAL----FYPWFRKAL 285
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
40-311 9.93e-08

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 52.37  E-value: 9.93e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVlGIPGNAIVIWFTGFK-WKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQ 118
Cdd:cd15213    3 LAILMILMIFV-GFLGNSIVCLIVYQKpAMRSAINLLLANLAFSDIMLSLVCMPFAAVTIITGRWIFGDIFCRISAMLYW 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIhlihpVLSHRHRTL--KNSLIVIIFIWLLASLIGGPALYFRDTVEF-NNHTLCYNNFQKHD 195
Cdd:cd15213   82 FFVLEGVAILLIISVDRYL-----IIVQRQDKLnpHRAKILIAVSWVLSFCVSFPPLVGWGKYEFpPRAPQCVLGYTESP 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 196 PDLtlirhhVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKrsilISSRHFWTILVVVVAFVVCWTPYHLFSIWeLTIHHN 275
Cdd:cd15213  157 ADR------IYVVLLLVAVFFIPFLIMLYSYFCILNTVRS----FKTRAFTTILILFIGFSVCWLPYTVYSLL-SVFSRY 225
                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 387763613 276 SYSHHVMQAGIPLstgLAFLNSCLNPILYVLISKKF 311
Cdd:cd15213  226 SSSFYVISTCLLW---LSYLKSAFNPVIYCWRIKKF 258
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
50-312 1.09e-07

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 52.52  E-value: 1.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  50 VLGIPGNAIV-IWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFL 128
Cdd:cd15078   12 FLGVCNNLLVlILYYKFKRLRTPTNLLLVNISLSDLLVSLLGVTFTFMSCVRGRWVFDVAGCVWDGFSNSLFGIVSIMTL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 129 TVISLDHYIHLIHPvlshRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTL-CYNNFQKHDPDLTLIrhhVLT 207
Cdd:cd15078   92 TVLAYERYIRVVHA----KVVNFSWSWRAITYIWLYSLAWTGAPLLGWNRYTLEVHGLgCSFDWKSKDPNDTSF---VLL 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 208 wvkFIIGYLF-PLLTMSICYLCLIFKVKKRSILISSRHFWTI-------------LVVVVAFVVCWTPYHLFSIWELtih 273
Cdd:cd15078  165 ---FFLGCLVvPLGIMAYCYGHILYEIRMLRSVEDLQTFQVIkilkyekkvakmcLLMISTFLICWMPYAVVSLLVT--- 238
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 387763613 274 hNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15078  239 -SGYSKLVTPTIAIIPSLFAKSSTAYNPVIYIFMIRKFR 276
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
43-315 1.26e-07

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 52.49  E-value: 1.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKKTV----TTLWFLNLAIAD-FIFLLFLPL-YISYVAMNFHWPFGIWLCKANSFT 116
Cdd:cd15135    5 LLYSLILVAGILGNSATIKVTQVLQKKGYlqksVTDHMVSLACSDlLVLLLGMPVeLYSAIWDPFATPSGNIACKIYNFL 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 117 AQLNMFASVFFLTVISLDHYIHLIHPvLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDT----VEFNNHTLCYNNFQ 192
Cdd:cd15135   85 FEACSYATILNVATLSFERYIAICHP-FKYKALSGSRVRLLICFVWLTSALVALPLLFAMGTedplEAFPSYRGTRHHCQ 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 193 KHDPDLTLIRHHVLTWVKF-------IIGYLFPLLtmSICYLC-----LIFKVKKRSILI-------------------S 241
Cdd:cd15135  164 DQKSNLTICTSLSSKWTVFqasifsaFVLYLLVLA--SVAFMCrrmmrALMGSKKGAVAVkgpggsvqllrkhesaegkT 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 242 SRHfWTILVV---VVAFVVCWTPYHLFSIWELTIHHNSYSHHVMQAGI---PLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15135  242 ARK-QTILFLgliVGTLAVCWMPNQIRRIMAAAKPKDDWTRSYFRAYIillPIADTFFYLSSVLNPLLYNLSSQQFRSVF 320
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
70-309 1.68e-07

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 51.86  E-value: 1.68e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  70 TVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHR 149
Cdd:cd15214   32 TLSNKFVFSLTLSNLLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGAIAIDRYYAVLYPMVYPMKI 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 150 TLKNSLIVIIFIWlLASLIGG-PALYFRDTVEFNNHT-LCYNNFQKhDPDLTLIrhhvltWVKFIIgyLFPLLTMSICYl 227
Cdd:cd15214  112 TGNRAVLALVYIW-LHSLIGClPPLFGWSSLEFDRFKwMCVAAWHK-EAGYTAF------WQVWCA--LLPFVVMLVCY- 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 228 CLIFKVKKRSiliSSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYSHHVMQagipLSTGLAFLNSCLNPILYVLI 307
Cdd:cd15214  181 GFIFRVARAN---QCKAFITILVVLGAFVTTWGPYMVVISTEALWGKNSVSPQLET----LATWLSFTSAVCHPLIYGLW 253

                 ..
gi 387763613 308 SK 309
Cdd:cd15214  254 NK 255
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
39-315 1.86e-07

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 52.17  E-value: 1.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIWFT-GFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPF-----GIWLCKA 112
Cdd:cd15975    1 YINTVLSCIIFIVGMVGNATLLRIIyQNKCMRNGPNALIASLALGDLIYIVIDIPINVYKLLAQKWPFddssfGVFLCKL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 113 NSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQ 192
Cdd:cd15975   81 VPFLQKASVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIFSIWVLSFILAIPEAIGFVMVPFEYNGEQYRTCM 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 193 KH-DPDLTLIRHHVLTWVKFIIGYLFPLLTMSICYL---CLIFKVKKRSILIS-SRHFW-------TILVVVVAFVVCWT 260
Cdd:cd15975  161 LNaTTKFMNFYVDAKDWWLFGFYFCVPLACTAIFYTlmtCEMLNRRKGSLRIAlSEHLKqrrevakTVFCLVVIFALCWF 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 261 PYHLFSIWELTIHHNSYSHHVMQAGIPL-----STGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15975  241 PLHLSRILKKTVYNENDPRRCELLSFLLvmdyiSINLATMNSCINPIALYFVSKKFKNCF 300
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
42-238 2.24e-07

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 51.68  E-value: 2.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAFVLGipgNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIF-LLFLPLYISYVAMNfHWPFGIWLCKANSFTAQL 119
Cdd:cd15058    7 LALIILAIVVG---NLLVIIaIARTSRLQTMTNIFITSLACADLVMgLLVVPLGATIVVTG-KWQLGNFWCELWTSVDVL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 120 NMFASVFFLTVISLDHYIHLIHPVlshRHRTLKNSL---IVIIFIWLLASLIG-GPALYFRDTVEFNNHTLCYNNfqKHD 195
Cdd:cd15058   83 CVTASIETLCVIAVDRYIAITRPL---RYQVLLTKRrarVIVCVVWIVSALVSfVPIMNQWWRANDPEANDCYQD--PTC 157
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 387763613 196 PDLTLIRHHVLtwVKFIIGYLFPLLTMsICYLCLIFKVKKRSI 238
Cdd:cd15058  158 CDFRTNMAYAI--ASSVVSFYIPLLIM-IFVYARVFLIATRQL 197
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
78-315 2.51e-07

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 51.08  E-value: 2.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  78 NLAIADFIF-LLFLPLYISYVAMNfHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLI 156
Cdd:cd15335   41 SLAVTDFLVaVLVMPLSITYIVMD-TWTLGYFICEIWLSVDMTCCTCSILHLCVIALDRYWAITDAIEYARKRTAKRAGL 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 157 VIIFIWLLASLIGGPALYFRDTVEFNNHTLCynnfqkhdpdltLIRH-HVLTWVKFIIGYLFPLLTMSICYLCLIFKVKK 235
Cdd:cd15335  120 MILTVWTISIFISIPPLFWRNHHDANIPSQC------------IIQHdHVIYTIYSTFGAFYIPLTLILILYYRIYHAAS 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 236 RSiLISSRHFWTILvvvVAFVVCWTPyhlFSIWELTIHHNSYShhVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15335  188 RE-RKAARILGLIL---GAFILSWLP---FFIKELIVGLSVMT--VSPEVADFLTWLGYVNSLVNPLLYTSFNEDFKLAF 258
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
77-171 2.91e-07

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 51.69  E-value: 2.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  77 LNLAIADFIFLLF-LPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSL 155
Cdd:cd15005   40 LDLCLADGLRSLAcFPFVMASVRHGSGWIYGALSCKVIAFLAVLFCFHSAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCL 119
                         90
                 ....*....|....*.
gi 387763613 156 IVIIFIWLLASLIGGP 171
Cdd:cd15005  120 AVICMAWTLSVAMAFP 135
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
43-315 3.35e-07

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 51.39  E-value: 3.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIwFTGFKwKKTVTTL------WFLNLAIADF-IFLLFLPLYI-SYVAMNFHWPFGIWLCKANS 114
Cdd:cd15355    5 AIYLALFVVGTVGNSITL-YTLAR-KKSLQHLqstvhyHLASLALSDLlILLLAMPVELyNFIWVHHPWAFGDAACRGYY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 115 FTAQLNMFASVFFLTVISLDHYIHLIHPV----LSHRHRTLKnsliVIIFIWLLASLIGGPALYfrdtvefnnhTLCYNN 190
Cdd:cd15355   83 FLRDACTYATALNVASLSVERYLAICHPFkaksLMSRSRTKK----FISAIWLASALLAIPMLF----------TMGEQN 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 191 FQKHDPD-------LTLIRHHVLTWVKFIIGYLFPLLTMSIC------YLCLIFK-VKKRSILISSRHFWTILVVVV--- 253
Cdd:cd15355  149 RSGTHPGglictpiVDTSTLKVVIQVNAFLSFLFPMLVISVLntlianQLTVMVNqAEQENQVCTIGGQRTVLSVSMepg 228
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 254 -----------------AFVVCWTPYHL-------FSIWELTIHHNSYSHHVMQagipLSTGLAFLNSCLNPILYVLISK 309
Cdd:cd15355  229 rvqslrhgvlvlravviAFVVCWLPYHVrrlmfcyVSDEQWTTFLYDFYHYFYM----LTNVLFYVSSAINPILYNLVSA 304

                 ....*.
gi 387763613 310 KFQARF 315
Cdd:cd15355  305 NFRQIF 310
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
74-315 3.35e-07

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 51.08  E-value: 3.35e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  74 LWFLNLAIAD-FIFLLFLPLYISYVAMNFhWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLK 152
Cdd:cd15321   43 LFLVSLAAADiLVATLIIPFSLANELMGY-WYFRKTWCEIYLALDVLFCTSSIVHLCAISLDRYWSVSRAIEYNSKRTPR 121
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 153 NSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLcynnfqkhdPDLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFK 232
Cdd:cd15321  122 RIKCIILIVWLIAAVISLPPLIYKGKQKDEQGGL---------PQCKLNEEAWYILSSSIGSFFAPCLIMILVYLRIYLI 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 233 VKKRsiliSSRHFWTILVVVVAFVVCWTP-YHLFSIWELTIHHNSYSHHVMQagipLSTGLAFLNSCLNPILYVLISKKF 311
Cdd:cd15321  193 AKNR----EKRFTFVLAVVIGVFVLCWFPfFFSYSLGAICPELCKVPHSLFQ----FFFWIGYCNSSLNPVIYTIFNQDF 264

                 ....
gi 387763613 312 QARF 315
Cdd:cd15321  265 RRAF 268
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
44-313 6.01e-07

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 50.15  E-value: 6.01e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIWFTGFKWKKTvTTLWFL--NLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15398    6 LYTFISLLGFLGNLLILTALTKKWKQK-TIINFLigNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQCVSV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVlsHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFN---------NHTLCYNNFQ 192
Cdd:cd15398   85 MVSTLMLMSIAIVRYHMIKHPL--SNHLTANHGYFLLGTVWTLGFTICSPLPVFHKIVDLSetfnleslkNKYLCIESWP 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 193 KHDPDLTLirhhvlTWVKFIIGYLFPLLTMSICYLCLIFKVKKrsiliSSRHFWTILVVVVAFVVCWTPYHLFSIwELTI 272
Cdd:cd15398  163 SDSYRIAF------TISLLFVQYILPLVCLTVSHTSVCRSVKR-----SRSVFYRLTIVILAFAVSWMPLHLFHL-VTDF 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 387763613 273 HHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQA 313
Cdd:cd15398  231 NANLISNRHFKLVYCICHLLGMLSCCLNPILYGFLNNGIKS 271
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
38-316 6.95e-07

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 49.95  E-value: 6.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  38 HWVSLVLYCLAFvLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADF-IFLLFLPLYISYVAMNfHWPFGIWLCKANSF 115
Cdd:cd15307    1 NYWALLALVLVL-GTAAGNILVCLAIAWERRlQNVTNYFLMSLAITDLmVAVLVMPLGILTLVKG-HFPLSSEHCLTWIC 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 116 TAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGP--ALYFRDtvefNNHTLCYNNFQK 193
Cdd:cd15307   79 LDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPlsLMYSKD----HASVLVNGTCQI 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 194 HDPDLTLIRHHVLTWVKFIIGYLFPLLTMSIcyLCLIFKVKKRSILISSRHFWTILVVVVAFVVCWTPYHLFSIweLTIH 273
Cdd:cd15307  155 PDPVYKLVGSIVCFYIPLGVMLLTYCLTVRL--LARQRSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNL--LPTV 230
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 387763613 274 HNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARFR 316
Cdd:cd15307  231 CAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFK 273
7tmA_MrgprA cd15105
mas-related G protein-coupled receptor subtype A, member of the class A family of ...
50-304 7.53e-07

mas-related G protein-coupled receptor subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320233  Cd Length: 276  Bit Score: 50.13  E-value: 7.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  50 VLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMfASVFFLT 129
Cdd:cd15105   12 LVGLTGNAIVFWLLGFRLHRNAFSVYILNLALADFLFLLCHIIDSTLLLLKVFYPNIIFLPCFYTIMMVLYI-TGLSMLS 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 130 VISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYF---RDTVEFNNHTLCYNNFqkhdpdltlirhhvl 206
Cdd:cd15105   91 AISTERCLSVLCPIWYRCRRPEHTSTVMCAVIWVLSLLICILNRYFcgfLDTKYENDSVCLASNF--------------- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 207 tWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILIsSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSyshHVMQAGI 286
Cdd:cd15105  156 -FTAAYLMFLFVVLCLSSLALLARLFCGAGQMKL-TRLYVTIMLTVLVFLLCGLPFGIYWFLLFWIKDDF---HVLDYGL 230
                        250
                 ....*....|....*....
gi 387763613 287 PLSTG-LAFLNSCLNPILY 304
Cdd:cd15105  231 YLASVvLTAVNSCANPIIY 249
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
43-315 8.52e-07

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 49.58  E-value: 8.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIV-IWFTGFKWKKTVTTLWFLNLAIADFIFL-LFLPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15310    5 LSYCALILAIVFGNVLVcMAVLRERALQTTTNYLVVSLAVADLLVAtLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMM 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHR---HRTLKNSLIVIIFIWLLASLIGGPALYFRDTVefNNHTLCynnfQKHDPD 197
Cdd:cd15310   85 CTASILNLCAISIDRYTAVVMPVHYQHgtgQSSCRRVSLMITAVWVLAFAVSCPLLFGFNTT--GDPTVC----SISNPD 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 LTLIRhhvlTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILIssrhfwtilVVVVAFVVCWTPYHLFSIweltIHHNSY 277
Cdd:cd15310  159 FVIYS----SVVSFYLPFGVTLLVYVRIYVVLLREKKATQMLA---------IVLGAFIVCWLPFFLTHI----LNTHCQ 221
                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 387763613 278 SHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15310  222 ACHVPPELYSATTWLGYVNSALNPVIYTTFNIEFRRAF 259
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
50-312 1.13e-06

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 49.45  E-value: 1.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  50 VLGIPGNAIVIWFTgFKWKKTVTTLWF--LNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFF 127
Cdd:cd15080   12 LLGFPINFLTLYVT-VQHKKLRTPLNYilLNLAVADLFMVFGGFTTTMYTSMHGYFVFGPTGCNLEGFFATLGGEIALWS 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 128 LTVISLDHYIHLIHPVLSHRHRTlKNSLIVIIFIWLLASLIGGPALY-FRDTVEFNNHTLCYNNFQKHDPDltlIRHHVL 206
Cdd:cd15080   91 LVVLAIERYVVVCKPMSNFRFGE-NHAIMGVAFTWVMALACAAPPLVgWSRYIPEGMQCSCGIDYYTLKPE---VNNESF 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 207 TWVKFIIGYLFPLLTMSICYLCLIFKVKK--------RSILISSRHFW-TILVVVVAFVVCWTPYHLFSIWELTIHHNSY 277
Cdd:cd15080  167 VIYMFVVHFTIPLIVIFFCYGRLVCTVKEaaaqqqesATTQKAEKEVTrMVIIMVIAFLICWVPYASVAFYIFTHQGSDF 246
                        250       260       270
                 ....*....|....*....|....*....|....*
gi 387763613 278 SHHVMQagipLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15080  247 GPIFMT----IPAFFAKSSAVYNPVIYILMNKQFR 277
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
78-316 1.14e-06

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 49.18  E-value: 1.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  78 NLAIADFIF-LLFLPLYISYVaMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLI 156
Cdd:cd15334   41 SLAVTDFLVaVLVMPFSIMYI-VKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGI 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 157 VIIFIWLLASLIGGPALYFRdtvefnnhtlcynNFQKHDPDLTLIRHH--VLTWVKFIIGYLFPLLTMSICYLcLIFKVK 234
Cdd:cd15334  120 MIAVVWIISIFISMPPLFWR-------------HQTTSREDECIIKHDhiVFTIYSTFGAFYIPLALILILYY-KIYRAA 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 235 KRsiliSSRHFWTILVVVVAFVVCWTPYHLFSIweltIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd15334  186 TR----ERKAATTLGLILGAFVICWLPFFVKEV----IVNTCDSCYISEEMSNFLTWLGYINSLINPLIYTIFNEDFKKA 257

                 ..
gi 387763613 315 FR 316
Cdd:cd15334  258 FQ 259
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
39-233 1.24e-06

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 49.55  E-value: 1.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGN--AIVIWFTGFK-WKKTVTTLWFLNLAIADFI-FLLFLPLYISYVAMNFHWPFGIWLCKANS 114
Cdd:cd14981    1 GESPAPPALMFVFGVLGNllALIVLARSSKsHKWSVFYRLVAGLAITDLLgILLTSPVVLAVYASNFEWDGGQPLCDYFG 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 115 FTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGG-PALYFRDTVEFNNHTLCYNNFQK 193
Cdd:cd14981   81 FMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASlPLLGLGSYVLQYPGTWCFLDFYS 160
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 387763613 194 HDPdltliRHHVLTWVKFIIGyLFPLLTMSICYLCLIFKV 233
Cdd:cd14981  161 KNT-----GDAAYAYLYSILG-LLILLVTLLCNLLVIITL 194
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
39-315 1.26e-06

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 49.44  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIWFT-GFKWKKTVTTLWFLNLAIADFIFLLF-LPLYI-SYVAMNF---HWPFGIWLCKA 112
Cdd:cd15128    1 YINTVVSCLIFIVGIIGNSTLLRIIyQNKCMRNGPNALIASLALGDLLYIVIdLPINVyKLLAMDWpfgDQPFGQFLCKL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 113 NSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPalyfrDTVEFNNHTLCYNNFQ 192
Cdd:cd15128   81 VPFIQKASVGITVLNLCALSVDRYRAVASWSRIQGIGIPMWTAVEIVMIWMLSAVLAVP-----EAIGFDMVRFNYKGVT 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 193 KHdpdlTLIRHHVLTWVKF--------IIGYLF--PLLTMSICY---LCLIFKVKKRSILIS-SRHFW-------TILVV 251
Cdd:cd15128  156 LR----TCLLRPETSFMKFyidvkdwwLFGFYFclPLVCTAIFYtlmTCEMLRKRNGMLRIAlNEHLKqrrevakTVFCL 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 387763613 252 VVAFVVCWTPYHLFSIWELTIHHNSYSHHVMQAGIPL-----STGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15128  232 VVIFALCWLPLHLSRILKLTVYDQNDPNRCELLSFLLvldyfGINLATLNSCINPIALYFVSRKFKNCF 300
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
42-304 1.32e-06

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 49.36  E-value: 1.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15384    4 IVVLAVMFVISFIGNLLTIIqIYRLRRSRRTIYSLLLHLAIADLLVTFFCIPSEAIWAYTVAWLAGNTMCKLVKYLQVFG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVlsHRHRTLKNSLIVIIFIWLLASLIGGPALY------------FRDTVEFNNHTlcy 188
Cdd:cd15384   84 LYLSTYITVLISLDRCVAILYPM--KRNQAPERVRRMVTVAWILSPIFSIPQAVifhvergpfvedFHQCVTYGFYT--- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 189 nnfqkhdpdlTLIRHHVLTWVKFIIGYLFPLLTMSICYLC----------------------------LIFKVKKRSILI 240
Cdd:cd15384  159 ----------AEWQEQLYNMLSLVFMFPIPLVIMVTCYVLifitlskssrdfqgleiytrnrgpnrqrLFHKAKVKSLRM 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 387763613 241 SSrhfwtilVVVVAFVVCWTPYHLFSIWELTIHHNSYSHHVMQAGIPLSTGlaflNSCLNPILY 304
Cdd:cd15384  229 SA-------VIVTAFILCWTPYYVIMIWFLFFNPYPLNDILFDVIFFFGMS----NSCVNPLIY 281
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
35-312 1.42e-06

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 49.41  E-value: 1.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  35 GVVHWVSLVLYCLAFV---LGIPGNAIVIWFTgFKWKKTVTTLWFL--NLAIADFIFLLFLPLyISYVAmNFHWPF--GI 107
Cdd:cd15082    7 SIAPWNFTVLAALMFVvtsLSLAENFAVMLVT-FRFKQLRQPLNYIivNLSVADFLVSLTGGT-ISFLT-NARGYFflGV 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 108 WLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTlKNSLIVIIFIWLLaSLIGG--PALYFRDTVEFNNHT 185
Cdd:cd15082   84 WACVLEGFAVTFFGIVALWSLAVLAFERFFVICRPLGNIRLQG-KHAALGLLFVWTF-SFIWTipPVLGWSSYTVSKIGT 161
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 186 LCYNNFQKhdpdlTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRS----ILISSRH-----FWTILVVVVAFV 256
Cdd:cd15082  162 TCEPNWYS-----GNMHDHTYIITFFTTCFILPLGVIFVSYGKLLQKLRKVSntqgRLGNARKperqvTRMVVVMIVAFM 236
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 387763613 257 VCWTPYHLFSIweLTIHHNSYSHHVMQAGIPlstglAFLN---SCLNPILYVLISKKFQ 312
Cdd:cd15082  237 VCWTPYAAFSI--LVTAHPTIHLDPRLAAIP-----AFFSktaAVYNPIIYVFMNKQFR 288
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
58-306 2.30e-06

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 48.70  E-value: 2.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  58 IVIWFTGFKWKKTVTTLWFLNLAIADFIF-LLFLPLYIsYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHY 136
Cdd:cd15318   21 VVVTVSHFKALHTPTNFLLLSLALADMLLgLTVLPFST-IRSVESCWYFGDSFCRLHTCLDTLFCLTSIFHLCFISIDRH 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 137 IHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTL----CYNNFQkhdpdltLIRHHVLTWVKFI 212
Cdd:cd15318  100 CAICDPLLYPSKFTIRVACIFIAAGWLVPTVYTSVFLYTKAVEEGLAELLtsvpCVGSCQ-------LLYNKLWGWLNFP 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 213 IgYLFPLLTMSICYLCLIFKVKKRSILISS-------------RHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYSh 279
Cdd:cd15318  173 V-FFIPCLIMIGLYVKIFIVAKRQARAIASllsdtngaskrerKAAKTLGIAVGVYLLCWLPFTIDTMVDSLLNFITPP- 250
                        250       260
                 ....*....|....*....|....*..
gi 387763613 280 hvmqAGIPLSTGLAFLNSCLNPILYVL 306
Cdd:cd15318  251 ----LLFDIIIWFAYFNSACNPLIYVF 273
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
69-315 2.54e-06

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 48.09  E-value: 2.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  69 KTVTTLWFLNLAIADFIFLLF-LPLYISYVAMNFhWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHR 147
Cdd:cd15298   32 QTVNNYFLFSLACADLIIGAFsMNLYTVYIIKGY-WPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPA 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 148 HRTLKNSLIVIIFIWLLASLIGGPALYF------RDTVEFNNhtlCYNNFqkhdpdltlIRHHVLTWVKFIIGYLFPLLT 221
Cdd:cd15298  111 RRTTKMAGLMIAAAWVLSFVLWAPAILFwqfvvgKRTVPDNQ---CFIQF---------LSNPAVTFGTAIAAFYLPVVI 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 222 MSICYLCLIFKVKKRSILISsrhfwTILVVVVAFVVCWTPYHLFSIWeltihhNSYSHHVMQAGI-PLSTGLAFLNSCLN 300
Cdd:cd15298  179 MTVLYIHISLASARERKVTR-----TIFAILLAFILTWTPYNVMVLV------NTFCQSCIPDTVwSIGYWLCYVNSTIN 247
                        250
                 ....*....|....*
gi 387763613 301 PILYVLISKKFQARF 315
Cdd:cd15298  248 PACYALCNATFKKTF 262
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
40-315 2.84e-06

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 47.98  E-value: 2.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVL-GIPGNAIVIWFTGF-KWKKTVTTLWFLNLAIADFIF-LLFLPLYISYVAMNFhWPFGIWLCKANSFT 116
Cdd:cd15327    1 VGVGVFLAIFILmAIVGNILVILSVACnRHLQTVTNYFIVNLAIADLLLsTTVLPFSATLEVLGF-WAFGRVFCDIWAAV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 117 AQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIG-GPALYFRDTVEfNNHTLCYNNfqkHD 195
Cdd:cd15327   80 DVLCCTASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISiGPLLGWKEPPP-PDESICSIT---EE 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 196 PDLTLIRHhvltwvkfIIGYLFPLLTMSICYLCLIFKVKKRSIliSSRHFWTILVVVVAFVVCWTPYhlFSIWELTIHHN 275
Cdd:cd15327  156 PGYALFSS--------LFSFYLPLMVILVMYFRVYVVALKFSR--EKKAAKTLAIVVGVFILCWFPF--FFVLPLGSFFP 223
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 387763613 276 SYSHHVMQAGIPLstGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15327  224 ALKPSEMVFKVIF--WLGYFNSCVNPIIYPCSSKEFKRAF 261
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
71-315 3.35e-06

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 47.92  E-value: 3.35e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  71 VTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRT 150
Cdd:cd15215   33 VANRFIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMT 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 151 LKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNFQKHDPDLTLIRHHVLTWVkfiigylfPLLTMSICYlCLI 230
Cdd:cd15215  113 PRRGYLLIYGTWIVSVLQSTPPLYGWGQAAFDERNALCSVIWGSSYSYTILSVVSSFVL--------PVIIMLACY-SMV 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 231 FKVKKRsiLISSRHFWTILVVVVAFVVCWTPYHLFSIWELtihhnSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKK 310
Cdd:cd15215  184 FRAARR--CYHCKAAKVIFIIIFSYVLSMGPYSFLSVLAV-----WVDTQVPQWVISIILWLFFLQCCIHPYIYGYMHKS 256

                 ....*
gi 387763613 311 FQARF 315
Cdd:cd15215  257 IKKEF 261
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
50-315 4.80e-06

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 47.58  E-value: 4.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  50 VLGIPGNAIVIWFTG-FKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFL 128
Cdd:cd15325   12 LFGVLGNILVILSVAcHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 129 TVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIG-GPALYFRDTVEfNNHTLCYNNfqkHDPDLTLIRhhvlt 207
Cdd:cd15325   92 CIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISiGPLFGWKEPAP-EDETICQIT---EEPGYALFS----- 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 208 wvkfIIGYLFPLLTMSICYLCLIFKVKKRsILISSRHFWTILVVVVAFVVCWTPYHLFsiweLTIHHNSYSHHVMQAGIP 287
Cdd:cd15325  163 ----ALGSFYLPLAIILVMYCRVYVVALK-FSREKKAAKTLGIVVGCFVLCWLPFFLV----MPIGSIFPAYKPSDTVFK 233
                        250       260
                 ....*....|....*....|....*...
gi 387763613 288 LSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15325  234 ITFWLGYFNSCINPIIYPCSSQEFKKAF 261
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
48-315 5.31e-06

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 47.19  E-value: 5.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  48 AFVL-GIPGNAIVIWFTGF-KWKKTVTTLWFLNLAIADFIF-LLFLPLYISYVAMNFhWPFGIWLCKANSFTAQLNMFAS 124
Cdd:cd15326    9 AFILfAIVGNILVILSVVCnRHLRIPTNYFIVNLAIADLLLsFTVLPFSATLEILGY-WVFGRIFCDIWAAVDVLCCTAS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 125 VFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIG-GPALYFRDTVEfnnhtlcynnfqKHDPDLTLIRH 203
Cdd:cd15326   88 ILSLCAISIDRYIGVRHSLQYPTIVTRKRAILALLGVWVLSTVISiGPLLGWKEPAP------------PDDKVCEITEE 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 204 HVLTWVKFIIGYLFPLLTMSICYlCLIFKVKKRsILISSRHFWTILVVVVAFVVCWTPYHlfsiweLTIHHNSYSHHVMQ 283
Cdd:cd15326  156 PFYALFSSLGSFYIPLIVILVMY-CRVYIVALK-FSREKKAAKTLGIVVGMFILCWLPFF------IALPLGSLFSHLKP 227
                        250       260       270
                 ....*....|....*....|....*....|....
gi 387763613 284 AGIPLST--GLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15326  228 PETLFKIifWLGYFNSCLNPIIYPCSSKEFKRAF 261
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
44-315 5.68e-06

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 47.25  E-value: 5.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  44 LYCLAFVLGIPGNAIVIwFTGFKwKKTVTTLW------FLNLAIADFIFLLF---LPLYiSYVAMNFHWPFGIWLCKANS 114
Cdd:cd15130    6 IYLALFVVGTVGNSVTL-FTLAR-KKSLQSLQstvryhLGSLALSDLLILLLampVELY-NFIWVHHPWAFGDAGCRGYY 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 115 FTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTV-EFNNHTLCYNNFQK 193
Cdd:cd15130   83 FLRDACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPMLFTMGLQnESDDGTHPGGLVCT 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 194 HDPDLTLIRhhVLTWVKFIIGYLFPLLTMSIcylclIFKVKKRSILISSRHFWTIL-VVVVAFVVCWTPYHLFSI----- 267
Cdd:cd15130  163 PIVDTATLK--VVIQVNTFMSFLFPMLVTSI-----LNTVIANKLVQALRRGVLVLrAVVIAFVVCWLPYHVRRLmfcyi 235
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 387763613 268 ----WElTIHHNSYSHHVMqagipLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15130  236 sdeqWT-TFLFDFYHYFYM-----LTNALFYVSSAINPILYNLVSANFRQVF 281
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
42-306 6.58e-06

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 47.06  E-value: 6.58e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYC---LAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTA 117
Cdd:cd15317    1 VIIYIvlvLAMLITVSGNLVVIIsISHFKQLHSPTNMLVLSLATADFLLGLCVMPFSMIRTVETCWYFGDLFCKFHTGLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 118 QLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYF----RDTVEFNNHTLCYNNFQk 193
Cdd:cd15317   81 LLLCTTSIFHLCFIAIDRYYAVCDPLRYPSKITVQVAWRFIAIGWLVPGIYTFGLIYTgandEGLEEYSSEISCVGGCQ- 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 194 hdpdltLIRHHVLTWVKFIIGYLfPLLTMSICYlCLIFKV-------------KKRSILISSRHFW---------TILVV 251
Cdd:cd15317  160 ------LLFNKIWVLLDFLTFFI-PCLIMIGLY-AKIFLVarrqarkiqnmedKFRSSEENSSKASasrerkaakTLAIV 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 387763613 252 VVAFVVCWTPYHLFSIWEltihhnSYSHHVMQAGI-PLSTGLAFLNSCLNPILYVL 306
Cdd:cd15317  232 MGIFLFCWLPYFIDTIVD------EYSNFITPAIVfDAVIWLGYFNSAFNPFIYAF 281
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
40-168 7.85e-06

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 47.04  E-value: 7.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLaFVLGIPGNAIVIW--FTGFKWKKTVTTLWFLNLAIAD-FIFLLFLPLYISYVAMNFhWPFGIWLCKANSFT 116
Cdd:cd15057    3 TGCILYLL-VLLTLLGNALVIAavLRFRHLRSKVTNYFIVSLAVSDlLVAILVMPWAAVNEVAGY-WPFGSFCDVWVSFD 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 387763613 117 AqLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLI 168
Cdd:cd15057   81 I-MCSTASILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALI 131
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
43-318 1.26e-05

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 46.08  E-value: 1.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTG-FKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15314    5 IFLGLISLVTVCGNLLVIISIAhFKQLHTPTNYLILSLAVADLLVGGLVMPPSMVRSVETCWYFGDLFCKIHSSFDITLC 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGgpalyFRDTVEFNNHTLCYNNFQKHDPDLTLI 201
Cdd:cd15314   85 TASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWSVSALVG-----FGIIFLELNIKGIYYNHVACEGGCLVF 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 202 RHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISSRHFW--------------TILVVVVAFVVCWTPYHLFSI 267
Cdd:cd15314  160 FSKVSSVVGSVFSFYIPAVIMLCIYLKIFLVAQRQARSIQSARTKsgassskmerkatkTLAIVMGVFLLCWTPFFLCNI 239
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 387763613 268 WELTIHHnSYSHHVMQAgiplSTGLAFLNSCLNPILYVLiskkFQARFRSS 318
Cdd:cd15314  240 IDPFINY-SIPPVLIEV----LNWLGYSNSTLNPFIYAF----FYSWFRKA 281
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
43-315 1.36e-05

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 46.21  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVI-WFTGFKWKKTVTTLWF-LNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLN 120
Cdd:cd15104    4 VILAVLSPLIITGNLLVIvALLKLIRKKDTKSNCFlLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 121 MFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCynNFqkhdpDLTL 200
Cdd:cd15104   84 CAASVLSLAAIAFDRYLALKQPLRYKQIMTGKSAGALIAGLWLYSGLIGFLPLISPQFQQTSYKGKC--SF-----FAAF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRHHVLTWvkFIIGYLFPLLTMSICYlCLIFKVKK---RSI---------LISSRHFW-------TILVVVVAFVVCWTP 261
Cdd:cd15104  157 HPRVLLVL--SCMVFFPALLLFVFCY-CDILKIARvhsRAIykvehalarQIHPRRTLsdfkaarTVAVLIGCFLLSWLP 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 387763613 262 YHLFSIWELTIHHNSYShHVMQAGIPLstgLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15104  234 FQITGLVQALCDECKLY-DVLEDYLWL---LGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
40-315 1.83e-05

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 45.71  E-value: 1.83e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFL-NLAIADFIF-LLFLPLYISYVA---MNFHwpfgiwlckANS 114
Cdd:cd14968    2 VYIVLEVLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIvSLAVADILVgALAIPLAILISLglpTNFH---------GCL 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 115 FTAQLNMF---ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALyfrdtveFNNHTLCYNNF 191
Cdd:cd14968   73 FMACLVLVltqSSIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPM-------FGWNNGAPLES 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 192 QKHDPDLT-----LIRHHVLTWVKFIIGYLFPLLTMSICYLcLIF-----KVKKRSILISSRHFWTIL-----------V 250
Cdd:cd14968  146 GCGEGGIQclfeeVIPMDYMVYFNFFACVLVPLLIMLVIYL-RIFrvirkQLRQIESLLRSRRSRSTLqkevkaakslaI 224
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 387763613 251 VVVAFVVCWTPYHLFSIWELTIHHNSYSHHVMQAGIPLStglaFLNSCLNPILYVLISKKFQARF 315
Cdd:cd14968  225 ILFLFALCWLPLHIINCITLFCPECKVPKILTYIAILLS----HANSAVNPIVYAYRIRKFRQTF 285
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
49-174 2.01e-05

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 45.58  E-value: 2.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  49 FVLGIPGNAIVIWFTgFKWKKTVTTLWFL--NLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVF 126
Cdd:cd15076   11 FIVGTPLNAIVLFVT-IKYKKLRQPLNYIlvNISLAGFIFCIFSVFPVFVASAQGYFFFGRTVCALEAFVGSLAGLVTGW 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 387763613 127 FLTVISLDHYIHLIHPVLSHRHRTlKNSLIVIIFIWLLASLIGGPALY 174
Cdd:cd15076   90 SLAFLAFERYIVICKPFGNFRFGS-KHALGAVVATWIIGIGVSLPPFF 136
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
43-175 2.35e-05

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 45.58  E-value: 2.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMF 122
Cdd:cd15150    5 LLYTVLFIVGLTMNGLAMRVFFQIPSKSNFIIFLKNTVISDLLMILTFPFKILSDAKLGSWPLRGFVCQVTSVIFYFTMY 84
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 387763613 123 ASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYF 175
Cdd:cd15150   85 ISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSTVIWASMFALSLPNMIL 137
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
42-306 2.44e-05

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 45.04  E-value: 2.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAFVLgipgNAI-VIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPL--YISYVAmnfHWPFGIWLCKANSFTAQ 118
Cdd:cd15072    8 LVEALVGFSL----NGLtILSFCKTRELRTPSNLLVLSLAVADMGISLNALVaaSSSLLR---RWPYGSEGCQAHGFQGF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMFASVFFLTVISLDHYIHLIHPvlsHRHRTlKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNH-TLCYNNFQKHDPD 197
Cdd:cd15072   81 FTALASICSSAAIAWDRYHHYCTR---SKLQW-STAISLVLFVWLFSAFWAAMPLLGWGEYDYEPLgTCCTLDYSKGDRN 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 198 LTlirhhVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKrsiliSSRHFWTILVVVVAFVVCWTPYHLFSIWElTIHHNSY 277
Cdd:cd15072  157 YV-----SYLFTMAFFNFILPLFILLTSYSSIEQKLKK-----EGHLRFNTGLPLLTLLICWGPYAILALYA-AITDVTS 225
                        250       260
                 ....*....|....*....|....*....
gi 387763613 278 SHHVMQAGIPLstgLAFLNSCLNPILYVL 306
Cdd:cd15072  226 ISPKLRMVPAL---LAKTSPTINAILYAL 251
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
32-168 2.55e-05

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 45.24  E-value: 2.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  32 VQLGVVhwVSLVLYCLAFvlgipGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIF-LLFLPLYISYVAMNfHWPFGIWL 109
Cdd:cd15957    1 VGMGIV--MSLIVLAIVF-----GNVLVITaIAKFERLQTVTNYFITSLACADLVMgLAVVPFGAAHILLK-TWTFGNFW 72
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 387763613 110 CKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLI 168
Cdd:cd15957   73 CEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLT 131
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
40-308 2.75e-05

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 45.15  E-value: 2.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIwFTGFKWKKTVTTL--WFLNLAIADFIFLLF--LPLYISYVAMNFHWPfgIWLCKANSF 115
Cdd:cd15388    2 VEIAVLAIIFACALLSNSLVL-LVLWRRRKQLARMhvFMLHLCIADLVVAFFqvLPQLVWDITDRFRGP--DVLCRLVKY 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 116 TAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIfIWLLASLIGGPALYFRDTVEFNNHTL-CYNNFQKh 194
Cdd:cd15388   79 LQVVGMFASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVCV-AWAISLILSLPQVFIFSKVEVAPGVYeCWACFIE- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 195 dpdlTLIRHHVLTWVKFIIgYLFPLLTMSICYLcLIFKVKKRSILISSRHFWTI-------------------------- 248
Cdd:cd15388  157 ----PWGLKAYVTWITLVV-FVLPTLIITVCQV-LIFKEIHINIYLKSQIIVAVvkkkqllssrassvaevskamiktvk 230
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 387763613 249 --LVVVVAFVVCWTPY---HLFSIWELTIHHNSyshhvmqAGIPLSTGLAFLNSCLNPILYVLIS 308
Cdd:cd15388  231 mtLVIVLVYVLCWAPFflvQLWSVWDPKAPTEG-------ATFTILMLLASLNSCTNPWIYMAFS 288
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
47-313 3.42e-05

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 44.82  E-value: 3.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  47 LAFVLGIPGNAIVIWFTgFKWKKTVTTLWFL--NLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFAS 124
Cdd:cd15077    9 FLVIAGFPINVLTIICT-IKYKKLRSHLNYIlvNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTATLGGMVS 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 125 VFFLTVISLDHYIHLIHPVLSHRHRTlKNSLIVIIFIWLLASLIGGPAL-----YFRDTVEFNNHTLCYNNFQKHDPDLT 199
Cdd:cd15077   88 LWSLAVVAFERFLVICKPLGNFTFRG-THAIIGCIATWVFGLAASLPPLfgwsrYIPEGLQCSCGPDWYTTNNKWNNESY 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 200 LIrhhvltwVKFIIGYLFPLLTMSICYLCLIFKVK--------KRSILISSRHFW-TILVVVVAFVVCWTPYHLFSIWEL 270
Cdd:cd15077  167 VM-------FLFCFCFGVPLSIIVFSYGRLLLTLRavakqqeqSASTQKAEREVTkMVVVMVLGFLVCWLPYASFALWVV 239
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 387763613 271 TihHNSYSHHVMQAGIPlsTGLAFLNSCLNPILYVLISKKFQA 313
Cdd:cd15077  240 T--NRGEPFDLRLASIP--SVFSKASTVYNPVIYVFMNKQFRS 278
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
40-315 4.52e-05

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 44.41  E-value: 4.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIF-LLFLPLYISYVAMNFhWPFG----------- 106
Cdd:cd15063    2 ISLLVLTFLNVLVVLGNLLVIAAVLCSRKlRTVTNLFIVSLACADLLVgTLVLPFSAVNEVLDV-WIFGhtwcqiwlavd 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 107 IWLCKAnsftaqlnmfaSVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTL 186
Cdd:cd15063   81 VWMCTA-----------SILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKDGIMDY 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 187 CYNNFQKHDPDLTLIRHHVLtwVKFIIGYLFPLLTMSICYLcLIFKVKKRSILISSrhfwTILVVVVAFVVCWTPYhlFS 266
Cdd:cd15063  150 SGSSSLPCTCELTNGRGYVI--YSALGSFYIPMLVMLFFYF-RIYRAARMETKAAK----TVAIIVGCFIFCWLPF--FT 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 387763613 267 IWELTIHhnsYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15063  221 VYLVRAF---CEDCIPPLLFSVFFWLGYCNSALNPCIYALFSRDFRFAF 266
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
43-236 7.17e-05

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 44.12  E-value: 7.17e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15958    5 LLMALIVLLIVAGNVLVIVAIGRTQRlQTLTNLFITSLACADLVMGLLVVPFGATLVVRGRWLYGSFFCELWTSVDVLCV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGG-PALYFRDTVEFNNHTLCYNNFQKHDpdltL 200
Cdd:cd15958   85 TASIETLCVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSFlPIMMHWWRDEDDQALKCYEDPGCCD----F 160
                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 387763613 201 IRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKR 236
Cdd:cd15958  161 VTNRAYAIASSIISFYIPLLIMIFVYLRVYREAKKQ 196
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
39-238 1.10e-04

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 43.36  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIwfTGFKWK---KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSF 115
Cdd:cd15959    1 WLAGALLSLAILVIVGGNLLVI--VAIAKTprlQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 116 TAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIG-GPAL--YFRDTVEfNNHTLCYNNFQ 192
Cdd:cd15959   79 VDVLCVTASIETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISfLPIMnqWWRDGAD-EEAQRCYDNPR 157
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 387763613 193 KHDpdltLIRHHVLTWVKFIIGYLFPLLTMSICYLcLIFKVKKRSI 238
Cdd:cd15959  158 CCD----FVTNMPYAIVSSTVSFYVPLLVMIFVYV-RVFVVATRQV 198
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
74-315 1.50e-04

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 42.94  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  74 LWFLNLAIAD-FIFLLFLPLYISYVAMNFhWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLK 152
Cdd:cd15324   37 LFLVSLASADiLVATLVIPFSLANEVMGY-WYFGSTWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTKAVSYNLKRTPK 115
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 153 NSLIVIIFIWLLASLIGGPALYfrdtvefnnhtlcynnFQKHDPDLTLIRHHvlTWVKF---IIGYLFPLLTMSICYlCL 229
Cdd:cd15324  116 RIKRMIAVVWVISAVISFPPLL----------------MTKHDEWECLLNDE--TWYILsscTVSFFAPGLIMILVY-CK 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 230 IFKVKKrsiLISSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYshhVMQAGIPLSTGLAFLNSCLNPILYVLISK 309
Cdd:cd15324  177 IYRVAK---MREKRFTFVLAVVMGVFVLCWFPFFFTYSLHAVCRKRCG---IPDALFNLFFWIGYCNSSVNPIIYTIFNR 250

                 ....*.
gi 387763613 310 KFQARF 315
Cdd:cd15324  251 DFRKAF 256
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
46-315 1.62e-04

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 42.62  E-value: 1.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  46 CLAFVLG------IPGNA-IVIWFTGFKWKKTVTTLWFLNLAIAD-FIFLLFLPLYISYVAMNFhWPFGIWLCKANSFTA 117
Cdd:cd15323    2 GLAAVVGflivftIVGNVlVVIAVLTSRALRAPQNLFLVSLASADiLVATLVMPFSLANELMGY-WYFGQVWCNIYLALD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 118 QLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPAL--YFRDTVEfNNHTLCYNNFQkhd 195
Cdd:cd15323   81 VLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPPLisMYRDPEG-DVYPQCKLNDE--- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 196 pdltlirhhvlTW--VKFIIGYLF-PLLTMSICYLcLIFKVKKRSiliSSRHFWTILVVVVAFVVCWTPYhLFSIWELTI 272
Cdd:cd15323  157 -----------TWyiLSSCIGSFFaPCLIMILVYI-RIYRVAKAR---EKRFTFVLAVVMGVFVVCWFPF-FFSYSLYGI 220
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 387763613 273 HHNSYShhVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15323  221 CREACE--VPEPLFKFFFWIGYCNSSLNPVIYTIFNQDFRRSF 261
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
40-315 2.24e-04

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 42.48  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVL-GIPGNAIVIWFTGF-KWKKTVTTLWFLNLAIADFIF-LLFLPLYISYVAMNFhWPFGIWLCKANSFT 116
Cdd:cd15062    1 IVVGVALGAFILfAIGGNLLVILSVACnRHLRTPTHYFIVNLAVADLLLsFTVLPFSATLEVLGY-WAFGRIFCDVWAAV 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 117 AQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIG-GPALYFRDTVEfNNHTLCYNNFQKhd 195
Cdd:cd15062   80 DVLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISiGPLLGWKEPAP-ADEQACGVNEEP-- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 196 pdltlirhhvlTWVKF--IIGYLFPLLTMSICYlCLIFKVKKRsILISSRHFWTILVVVVAFVVCWTPYHLFsiweLTIH 273
Cdd:cd15062  157 -----------GYVLFssLGSFYLPLAIILVMY-CRVYVVAFK-FSREKKAAKTLGIVVGAFVLCWFPFFVV----LPLG 219
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 387763613 274 HNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15062  220 SLFSTLKPPEPVFKVVFWLGYFNSCLNPIIYPCSSREFKRAF 261
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
47-171 3.49e-04

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 41.68  E-value: 3.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  47 LAFVLGIPGNAIVIWFTgFKWK--KTVTTLWFLNLAIADFI-FLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFA 123
Cdd:cd15212    9 AIFLLSSLGNCAVIGVI-VKHRqlRTVTNAFILSLSLSDLLtALLCLPFAFLTLFSRPGWLFGDRLCLANGFFNACFGIV 87
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 387763613 124 SVFFLTVISLDHYIHLIHPvlsHRHRTLKNS-LIVIIFIWLLASLIGGP 171
Cdd:cd15212   88 STLTMTLISFDRYYAIVRQ---PQGKIGRRRaLQLLAAAWLTALGFSLP 133
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
43-314 3.70e-04

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 41.69  E-value: 3.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTgFKWKKTVTTLWFL-NLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15151    5 VLYTVLFLVGLILNSVAAWIF-FHIPSTSTFIVYLkNTLVADLIMTLMLPFKILSDSGLGPWQLRAFVCRFSAVVFYITM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPalyfrdTVEFNNHTLCYNNFQK---HDPDL 198
Cdd:cd15151   84 YISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVP------NMILSNKPATPISVKKcasLKSPL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 199 TLIRHHVLTWV-KFIIGYLFPLltMSICYLCLIFKV-------KKRSILISSRHFWTILVVVVAFVVCWTPYHL----FS 266
Cdd:cd15151  158 GLKWHEVVNYIcQFIFWGVFAL--MVLFYTIISKKVyesykksRSKDNKASKKTKAKVFIIVAVFFVCFAPFHFvrvpYT 235
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 387763613 267 IWELTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd15151  236 LSQTGKITDCQLQNLLYIAKEITLWLAATNVCLDPLIYIFLCKSFRQR 283
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
42-270 4.44e-04

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 41.32  E-value: 4.44e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAmNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd14994    5 IFLYSVVLIGGVIGVILMSFLLVKMNTRSVTTTAVINLIVVHSLFLLTVPFRIYYYA-SKTWKFGMPLCKMVSAMIHIHM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFN-NHTLCYNnFQKhdpdlTL 200
Cdd:cd14994   84 HLTFLFYVIILVIRYLIFFQRKDKMEFYRKLHAVAASAVVWVLVLLIVVPVFVKEYGSSSSyNSDQCFK-FHK-----EL 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 IRHHVLtwvkfIIGYLFPLLTMSICYLCLIFKV--------KKRSILISSRHFWT---ILVVVVAFVVCWTPYHLFSIWE 269
Cdd:cd14994  158 EVHYVK-----VLNYIIICIVLIVTLALLGFQVfilghvyrKLRASLLSHQEFWAqmkSLFFIVVIIVCFVPYNLFRIYY 232

                 .
gi 387763613 270 L 270
Cdd:cd14994  233 L 233
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
47-168 4.78e-04

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 41.21  E-value: 4.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  47 LAFVLGIPGNAIVIWFTGFKWKKTVTTLWFL-NLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKA-NSFTAQLNMfAS 124
Cdd:cd15066    8 LIILAAIFGNLLVIISVMRHRKLRVITNYFVvSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVwNSLDVYFST-AS 86
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 387763613 125 VFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLI 168
Cdd:cd15066   87 ILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLANVWISPALI 130
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
43-315 5.06e-04

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 41.39  E-value: 5.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFT----GFKWKKTVTTLWFLNLAIADFIFLLF---LPLYiSYVAMNFHWPFGIWLCKANSF 115
Cdd:cd15356    5 AVYALIWALGAAGNALTIHLVlkkrSLRGLQGTVHYHLVSLALSDLLILLIsvpIELY-NFVWFHYPWVFGDLVCRGYYF 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 116 TAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWlLASLIGGPALYFRDTVEFNNHTlcynnfQKHD 195
Cdd:cd15356   84 VRDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIW-ASSLGFALPMAFIMGQKYELET------ADGE 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 196 PD---------LTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSIlisSRHFWTILVVVVAFVVCWTPYHLFS 266
Cdd:cd15356  157 PEpssrvctvlVSRATLKVFIQVNAFVSFVLPLALIAFLNGVTVSHLRIQSL---QHSVQVLRAIVIAYVICWLPYHARR 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 387763613 267 I---------WELTIhHNSYSHHVMqagipLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15356  234 LmfcyvpddaWTDSL-YNFYHYFYM-----LTNTLFYVSSAVNPLLYNVVSSSFRKLF 285
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
40-315 8.77e-04

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 40.55  E-value: 8.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGipgNAIVIwFTGFKWKKTVTTLWFL--NLAIADFIF-LLFLPLYISYVAMNfHWPFG-----IWLCK 111
Cdd:cd15333    9 VLLALITLATTLS---NAFVI-ATIYLTRKLHTPANYLiaSLAVTDLLVsILVMPISIVYTVTG-TWTLGqvvcdIWLSS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 112 ANSFTAqlnmfASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHTLCYNNf 191
Cdd:cd15333   84 DITCCT-----ASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEVSECVVN- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 192 qkhdpdltliRHHVLTWVKFIIG-YLFPLLTMSICYLCLIFKVKKRsiliSSRHFWTILVVVVAFVVCWTPYHLFSIwEL 270
Cdd:cd15333  158 ----------TDHILYTVYSTVGaFYIPTLLLIALYGRIYVEARAR----ERKATKTLGIILGAFIVCWLPFFIISL-VL 222
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 387763613 271 TIHHNSYSHHVmqAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15333  223 PICKDACWFHL--AIFDFFTWLGYLNSLINPIIYTMSNEDFKQAF 265
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
39-312 8.96e-04

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 40.65  E-value: 8.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGN--AIVIWFTGFKWKKTVTTLWFLNLAIADfIFLLFLPLYISYVAMNF--HWPFGIWLCKANS 114
Cdd:cd15919    1 FVPVIYYSLLLCLGLPANilTVIILSQLVARRQKSSYNYLLALAAAD-ILVLFFIVFVDFLLEDFilNKQMPQVLDKIIE 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 115 FTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVefnnhtlcynnfqkH 194
Cdd:cd15919   80 VLEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIW--------------I 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 195 DPDLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSIL-----ISSRHFWTILVVVVAFVVCWTPYHLFSIWE 269
Cdd:cd15919  146 EDYTSTSMHHVLIWIHCFTVYLVPCSIFFVLNSIIVYKLRRKSNFrlrgySTGKTTAILFTITSIFAILWAPRIIMILYH 225
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 387763613 270 LTIH--HNSYSHHVMQagiPLSTGLAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15919  226 LYVSpiNNSWLVHIVS---DIANMLALLNTAINFFLYCFISKRFR 267
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
38-315 9.47e-04

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 40.40  E-value: 9.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  38 HWVSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTA 117
Cdd:cd15309    1 NYYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLD 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 118 QLNMFASVFFLTVISLDHYIHLIHPVL-SHRHRTLKNSLIVIIFIWLLASLIGGPALYfrdtvefnnhtlcynNFQKHDP 196
Cdd:cd15309   81 VMMCTASILNLCAISIDRYTAVAMPMLyNTRYSSKRRVTVMISVVWVLSFAISCPLLF---------------GLNNTDQ 145
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 DLTLIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFKVKKRSilissRHFWTILVVVVAFVVCWTPYHLFSIweLTIHHNS 276
Cdd:cd15309  146 NECIIANPAFVVYSSIVSFYVPFIVTLLVYVQIYIVLQKEK-----KATQMLAIVLGVFIICWLPFFITHI--LNMHCDC 218
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 387763613 277 yshHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15309  219 ---NIPPALYSAFTWLGYVNSAVNPIIYTTFNIEFRKAF 254
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
39-175 1.12e-03

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 40.41  E-value: 1.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGN-AIVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTA 117
Cdd:cd15312    1 VAMYLFMAGAILLTVFGNlMVIISISHFKQLHSPTNFLILSLAITDFLLGFLVMPYSMVRSVESCWYFGDLFCKIHSSLD 80
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 387763613 118 QLNMFASVFFLTVISLDHYIHLIHPvLSHRHRTLKNSLIVIIFIWLLASLIGGPALYF 175
Cdd:cd15312   81 MMLSTTSIFHLCFIAVDRYYAVCDP-LHYRTKITTPVIKVFLVISWSVPCLFAFGVVF 137
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
42-236 1.39e-03

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 40.02  E-value: 1.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  42 LVLYCLAFVLGIP--GNAIV-IWFTGFKWKKTVTTLWFLNLAIADFI-FLLFLPLYISYVAMNFHWPFGIWLCKANSFTA 117
Cdd:cd15218    2 LKLTSLGFIIGVSvvGNLLIsILLVKDKTLHRAPYYFLLDLCCSDILrSAICFPFVFTSVKNGSTWTYGTLTCKVIAFLG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 118 QLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEF----NNHTLCYNNFQK 193
Cdd:cd15218   82 VLSCFHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFPPVLDVGTYSFireeDQCTFQHRSFRA 161
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 387763613 194 HDPdltlirhhvltwVKFIIGYLFPLLTMSICYLCLIFKVKKR 236
Cdd:cd15218  162 NDS------------LGFMLLLALILLATQLVYLKLIFFVHDR 192
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
43-312 2.00e-03

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 39.45  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIWFTGFK-WKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNM 121
Cdd:cd15403    5 IVMILMIAIGFLGNAIVCLIVYQKpAMRSAINLLLATLAFSDIMLSLLCMPFTAVTIITVDWHFGAHFCRISAMLYWFFV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 122 FASVFFLTVISLDHYIHLihpVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEFNNHT-LCYNNFQKHDPDltl 200
Cdd:cd15403   85 LEGVAILLIISVDRFLII---VQRQDKLNPHRAKVMIAISWVLSFCISFPSVVGWTLVEVPARApQCVLGYTESPAD--- 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 201 iRHHVLTWVKFIigYLFPLLTMSICYLCLIFKVKKRSILI--------------------------------SSRHFWTI 248
Cdd:cd15403  159 -RVYAVLLVVAV--FFVPFSIMLYSYLCILNTVRRNAVRIhnhadslclsqvsklglmglqrphqmnvdmsfKTRAFTTI 235
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 387763613 249 LVVVVAFVVCWTPYHLFSIWELTIHHNSYShhvmQAGIPLSTG---LAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15403  236 LILFVGFSLCWLPHTVFSLLSVFSRRFYYS----SSFYPISTCvlwLSYLKSVFNPVIYCWRIKKFR 298
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
57-168 2.26e-03

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 39.60  E-value: 2.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  57 AIVIWFTGFKWKktVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFG----IWLckanSFTAQLNMfASVFFLTVIS 132
Cdd:cd15320   24 AAVIRFRHLRSK--VTNFFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGsfcnIWV----AFDIMCST-ASILNLCVIS 96
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 387763613 133 LDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLI 168
Cdd:cd15320   97 VDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLI 132
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
40-315 2.53e-03

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 39.15  E-value: 2.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVIWFTGFKWK-KTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKAnSFTAQ 118
Cdd:cd15069    2 TYVALELIIAALSVAGNVLVCAAVGTNSTlQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFHSCLFLA-CFVLV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 119 LNMfASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIG-GPALYFRDT-VEFNNHTLCYNNFQKHDP 196
Cdd:cd15069   81 LTQ-SSIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGlTPFLGWNKAmSATNNSTNPADHGTNHSC 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 197 DL------TLIRHHVLTWVKFIIGYLFPLLTMSICYLcLIFKV------------KKRSILISSRHFWTILVVVV-AFVV 257
Cdd:cd15069  160 CLisclfeNVVPMSYMVYFNFFGCVLPPLLIMLVIYI-KIFLVacrqlqrtelmdHSRTTLQREIHAAKSLAIIVgIFAL 238
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 387763613 258 CWTPYHLFSIweLTIHHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15069  239 CWLPVHILNC--ITLFQPEFSKSKPKWAMNVAILLSHANSVVNPIVYAYRNRDFRYTF 294
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
40-164 2.67e-03

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 39.22  E-value: 2.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  40 VSLVLYCLAFVLGIPGNAIVI--WFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTA 117
Cdd:cd15169    2 LSFGLYVAAFALGFPLNVLAIrgATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAH 81
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 387763613 118 QLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLL 164
Cdd:cd15169   82 FAPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWAL 128
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
47-315 3.74e-03

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 38.39  E-value: 3.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  47 LAFVLGIPGNAIVIW--FTGfKWKKTVTTLWFLNLAIAD-FIFLLFLPLYISYVAMNFhWPFGIWLCKANSFTAQLNMFA 123
Cdd:cd15322    9 LLMLLTVFGNVLVIIavFTS-RALKAPQNLFLVSLASADiLVATLVIPFSLANEVMGY-WYFGKVWCEIYLALDVLFCTS 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 124 SVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYfrdTVEfnnhtlcyNNFQKHDPDLTLIRH 203
Cdd:cd15322   87 SIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLI---TIE--------KKSGQPEGPICKIND 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 204 HVLTWVKFIIGYLF-PLLTMSICYLCLIFKVKKRsiliSSRHFWTILVVVVAFVVCWTPYhlFSIWELTIHHNSYshhVM 282
Cdd:cd15322  156 EKWYIISSCIGSFFaPCLIMVLVYIRIYQIAKNR----EKRFTFVLAVVIGVFVICWFPF--FFTYTLTAVCDCS---VP 226
                        250       260       270
                 ....*....|....*....|....*....|...
gi 387763613 283 QAGIPLSTGLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15322  227 ETLFKFFFWFGYCNSSLNPVIYTIFNHDFRRAF 259
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
68-168 4.42e-03

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 38.40  E-value: 4.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  68 KKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMfASVFFLTVISLDHYIHLIHPVLSHR 147
Cdd:cd15319   32 RSKVTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDVWVAFDIMCST-ASILNLCVISVDRYWAISSPFRYER 110
                         90       100
                 ....*....|....*....|.
gi 387763613 148 HRTLKNSLIVIIFIWLLASLI 168
Cdd:cd15319  111 KMTQRVALVMISVAWTLSVLI 131
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
39-181 4.55e-03

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 38.39  E-value: 4.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  39 WVSLVLYCLAFVLGIPGNAIVIWFTGFKWKKTVTTLWFL-NLAIADFI-FLLFLPLYISYVAMNFHWPFGIWLCKANSFT 116
Cdd:cd15217    1 YVKLVLLGLIICVSLAGNLIVSLLVLKDRALHKAPYYFLlDLCLADTIrSAVCFPFVLVSIRNGSAWTYSVLSCKIVAFM 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 387763613 117 AQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALYFRDTVEF 181
Cdd:cd15217   81 AVLFCFHAAFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFDVGTYKF 145
7tmA_MrgprG cd15111
mas-related G protein-coupled receptor subtype G, member of the class A family of ...
41-87 4.59e-03

mas-related G protein-coupled receptor subtype G, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320239  Cd Length: 263  Bit Score: 38.23  E-value: 4.59e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 387763613  41 SLVLYCLAFV--LGIPGNAIVIWFTGFKWKKTVTTLWFLNLAIADFIFL 87
Cdd:cd15111    1 KVVFYLTLIVslAGLVGNGLVLWHLGFHIKKGPFSNYLLHLAAADFLFL 49
7tmA_FSH-R cd15360
follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G ...
43-315 4.63e-03

follicle-stimulating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. FSH-R functions in gonad development and is found in the ovary, testis, and uterus. Defects in this receptor cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. The FSH-R activation couples to the G(s)-protein and stimulates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320482  Cd Length: 275  Bit Score: 38.30  E-value: 4.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIV-IWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYIS--------YVAMNFHWPFGIWlCKAN 113
Cdd:cd15360    5 VLIWFINILAITGNIVVlAILLTSQYKLTVPRFLMCNLAFADLCMGIYLLLIASvdirtksqYYNYAIDWQTGAG-CAAA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 114 SFTAQLNMFASVFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGgpALYFRDTVEFNNHTLCYnnfqK 193
Cdd:cd15360   84 GFFTVFASELSVYTLTVITLERWHTITYAMQLDRKVRLRHAAVIMVGGWIFAFTVA--LLPIFGISSYMKVSICL----P 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 194 HDPDLTLIRHHVltwVKFIIGYLFPLLTMSICYLCLIFKVKKRSILISS---RHFWTILVVVVAFVVCWTPYHLFSIwel 270
Cdd:cd15360  158 MDIESPLSQAYI---IFILVLNVLAFLIICACYIKIYLTVRNPNFVSSNsdtKIAKRMAVLIFTDFLCMAPISFFAI--- 231
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 387763613 271 tihhnSYSHHVMQAGIPLSTGLAFL----NSCLNPILYVLISKKFQARF 315
Cdd:cd15360  232 -----SASLKVPLITVSKSKILLVLfypiNSCANPFLYAIFTKTFRRDF 275
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
50-174 5.29e-03

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 38.30  E-value: 5.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  50 VLGIPGNAIV-IWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAMNFHWPFGIWLCKANSFTAQLNMFASVFFL 128
Cdd:cd15316   12 VLAVFGNLLVmISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTFHTCCDVSFCYASLFHL 91
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 387763613 129 TVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGGPALY 174
Cdd:cd15316   92 CFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFSVFY 137
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
77-315 8.52e-03

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 37.33  E-value: 8.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  77 LNLAIAD-FIFLLFLPLYISYvAMNFHWPFGIWLCKANSFTAQLNMFASVFFLTVISLDHYiHLIHPVLSHRHRTLKNSL 155
Cdd:cd15331   40 LSLAVADlMVAVLVMPLSAVY-EVSQHWFLGPEVCDMWISMDVLCCTASILHLVAIALDRY-WAVTNIDYIRRRTAKRIL 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 156 IVIIFIWLLASLIGGPALYFRDTVEFNNhtlcynnfqkhDPDLT---LIRHHVLTWVKFIIGYLFPLLTMSICYLCLIFK 232
Cdd:cd15331  118 IMIAVVWFVSLIISIAPLFGWKDEDDLD-----------RVLKTgvcLISQDYGYTIFSTVGAFYVPLLLMIIIYWKIYQ 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 233 VKKRSilisSRHFWTILVVVVAFVVCWTPYHLFSIWELTIHHNSYSHHVMQAGIPLstglAFLNSCLNPILYVLISKKFQ 312
Cdd:cd15331  187 AAKRE----RKAARTLAIITGAFVVCWLPFFLVALVMPFCGAWQISRFLESFFLWL----GYFNSLLNPIIYTIFSPDFR 258

                 ...
gi 387763613 313 ARF 315
Cdd:cd15331  259 GAF 261
7tmA_LHCGR cd15359
luteinizing hormone-choriogonadotropin receptor, member of the class A family of ...
43-315 9.27e-03

luteinizing hormone-choriogonadotropin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. LHCGR is expressed predominantly in the ovary and testis, and plays an essential role in sexual development and reproductive processes. LHCGR couples primarily to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production.


Pssm-ID: 320481 [Multi-domain]  Cd Length: 275  Bit Score: 37.54  E-value: 9.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  43 VLYCLAFVLGIPGNAIVIW-FTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYIS--------YVAMNFHWPFGIWLCKAN 113
Cdd:cd15359    5 VLIWFINILAIAGNLIVLFvLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASvdsqtksqYYNHAIDWQTGSGCSTAG 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 114 SFTaqlnMFAS---VFFLTVISLDHYIHLIHPVLSHRHRTLKNSLIVIIFIWLLASLIGgpALYFRDTVEFNNHTLCYnn 190
Cdd:cd15359   85 FFT----VFASelsVYTLTVITLERWHTITYAMQLDRKLRLRHAILIMLGGWVFSLLIA--VLPLVGVSNYMKVSICL-- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 191 fqKHDPDLTLIRHHVLTwvkFIIGYLFPLLTMSICYLCLIFKVKKRSILIS---SRHFWTILVVVVAFVVCWTPYHLFSI 267
Cdd:cd15359  157 --PMDIETLLSQAYILL---ILVLNVIAFLVICACYIKIYLAVQNPELVAKnkdTKIAKRMAILIFTDFTCMAPISFFAI 231
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 387763613 268 -----WELTIHHNSYSHHVMqagiplstgLAFLNSCLNPILYVLISKKFQARF 315
Cdd:cd15359  232 saafkVPLITVTNSKILLVL---------FYPINSCANPFLYAIFTKAFRRDF 275
7tmA_GPR146 cd14990
G protein-coupled receptor 146, member of the class A family of seven-transmembrane G ...
41-314 9.79e-03

G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR146 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. The endogenous ligand for GPR146 is not known. It has been suggested that GPR146 may be a part of the C-peptide signaling complex. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320121  Cd Length: 280  Bit Score: 37.45  E-value: 9.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613  41 SLVLYCLAFVLGIPGNA-IVIWFTGFKWKKTVTTLWFLNLAIADFIFLLFLPLYISYVAmNFHWPfgIWLCKANSFTAQL 119
Cdd:cd14990    3 SLLYLIICFPVGLCYNAlLVLVNLYNKASMTMPDVYFVNMAIAGLVLNAVAPVQLLGPD-NTRWP--LWNSNNEVYITLL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 120 NMF-----ASVFFLTVISLDHYIHLIHPvlshrhRTLKNSLI----VIIFIWLLASLIGGPALYFRDTVEFNNHTL-CYN 189
Cdd:cd14990   80 ILFnvsslVSMYSTTLLSLDYYIERALP------RTYMSSVYntkhVCGFIWGGAVLTSFSSLLFYICSHVSTKIIeCSK 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387763613 190 NFQKHDPDLTLirhhvltwvkFIIGYLFPLLTMsICYLCLIFKVKKRSILI---SSR----HFWTILVVVVAFVVCWTPY 262
Cdd:cd14990  154 MQNKEAADAIM----------VFIGYVVPALAV-LYALVLILRIRKEATPLdqdSGRldpsAHRLLLATVCTQFLLWTPY 222
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 387763613 263 HLFSIWELTI-----HHNSYSHHVMQAGIPLSTGLAFLNSCLNPILYVLISKKFQAR 314
Cdd:cd14990  223 YMILLVHTVQasrgkKVDAGYLRVFHFLKGLSKLLAFSSSFVVPLLYRYMNKNFSSK 279
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH