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Conserved domains on  [gi|387848961|ref|NP_001248389|]
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zinc finger protein 484 isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
374-775 2.42e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 2.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 374 KPYVCTECGKAFIRKSHFITHERIHTGEKPYECSD--CGKSFIKKSQLHVHQRIHTGENPFICSECGKVFTHKTN-LIIH 450
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASsSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 451 QKIHTGERPYICTVCGKAFTDRSNLIKHQKIHTGEKPYKCSDCGKSFTW-KSRLRIHQKCHTGERHYECSECGKAFIQKS 529
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 530 TLSMHQRIHrgekpyvCTECGKAFFHKSHFITHERIHTGEKPYECSICGKSFTKKSQLHVHQQIHTGEKPYRCAECGKAF 609
Cdd:COG5048  192 VSTSIPSSS-------ENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 610 TDRSNLFTHQKIHTGE-------KPYKCSDCGKAFTRKSGLHIHQQS--HTGERHYECSE----CGKAFARKSTLIMHQR 676
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 677 IHTGEKPYIC--NECGKSFIQKSHLNRH-----RRIHTGEKPYECSDCGKSFIKKS----QLHEHHRIHTGEKPYICAEC 745
Cdd:COG5048  345 LHTSISPAKEklLNSSSKFSPLLNNEPPqslqqYKDLKNDKKSETLSNSCIRNFKRdsnlSLHIITHLSFRPYNCKNPPC 424

                        410       420       430
                 ....*....|....*....|....*....|
gi 387848961 746 GKAFTIRSNLIKHQKIHTKQKPYKCSDLGK 775
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
KRAB super family cl42959
krueppel associated box;
1-31 2.78e-09

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 53.75  E-value: 2.78e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 387848961     1 MLENYFNLISVGCQVPKPEVIFSLEQ-EEPCM 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQgEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
334-359 6.83e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.83e-03
                          10        20
                  ....*....|....*....|....*.
gi 387848961  334 NLNIHKKIHTGGKHFECTECGKAFTR 359
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
374-775 2.42e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 2.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 374 KPYVCTECGKAFIRKSHFITHERIHTGEKPYECSD--CGKSFIKKSQLHVHQRIHTGENPFICSECGKVFTHKTN-LIIH 450
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASsSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 451 QKIHTGERPYICTVCGKAFTDRSNLIKHQKIHTGEKPYKCSDCGKSFTW-KSRLRIHQKCHTGERHYECSECGKAFIQKS 529
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 530 TLSMHQRIHrgekpyvCTECGKAFFHKSHFITHERIHTGEKPYECSICGKSFTKKSQLHVHQQIHTGEKPYRCAECGKAF 609
Cdd:COG5048  192 VSTSIPSSS-------ENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 610 TDRSNLFTHQKIHTGE-------KPYKCSDCGKAFTRKSGLHIHQQS--HTGERHYECSE----CGKAFARKSTLIMHQR 676
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 677 IHTGEKPYIC--NECGKSFIQKSHLNRH-----RRIHTGEKPYECSDCGKSFIKKS----QLHEHHRIHTGEKPYICAEC 745
Cdd:COG5048  345 LHTSISPAKEklLNSSSKFSPLLNNEPPqslqqYKDLKNDKKSETLSNSCIRNFKRdsnlSLHIITHLSFRPYNCKNPPC 424

                        410       420       430
                 ....*....|....*....|....*....|
gi 387848961 746 GKAFTIRSNLIKHQKIHTKQKPYKCSDLGK 775
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
KRAB smart00349
krueppel associated box;
1-31 2.78e-09

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 53.75  E-value: 2.78e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 387848961     1 MLENYFNLISVGCQVPKPEVIFSLEQ-EEPCM 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQgEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
698-721 2.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.40e-04
                          10        20
                  ....*....|....*....|....
gi 387848961  698 HLNRHRRIHTGEKPYECSDCGKSF 721
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 598-650 1.29e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 1.29e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 387848961 598 KPYrCAECGKAFTDRSNLFTHQKIHTgekpYKCSDCGKAFTRKSGLHIH-QQSH 650
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
334-359 6.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.83e-03
                          10        20
                  ....*....|....*....|....*.
gi 387848961  334 NLNIHKKIHTGGKHFECTECGKAFTR 359
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
374-775 2.42e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.19  E-value: 2.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 374 KPYVCTECGKAFIRKSHFITHERIHTGEKPYECSD--CGKSFIKKSQLHVHQRIHTGENPFICSECGKVFTHKTN-LIIH 450
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASsSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 451 QKIHTGERPYICTVCGKAFTDRSNLIKHQKIHTGEKPYKCSDCGKSFTW-KSRLRIHQKCHTGERHYECSECGKAFIQKS 529
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 530 TLSMHQRIHrgekpyvCTECGKAFFHKSHFITHERIHTGEKPYECSICGKSFTKKSQLHVHQQIHTGEKPYRCAECGKAF 609
Cdd:COG5048  192 VSTSIPSSS-------ENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 610 TDRSNLFTHQKIHTGE-------KPYKCSDCGKAFTRKSGLHIHQQS--HTGERHYECSE----CGKAFARKSTLIMHQR 676
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 677 IHTGEKPYIC--NECGKSFIQKSHLNRH-----RRIHTGEKPYECSDCGKSFIKKS----QLHEHHRIHTGEKPYICAEC 745
Cdd:COG5048  345 LHTSISPAKEklLNSSSKFSPLLNNEPPqslqqYKDLKNDKKSETLSNSCIRNFKRdsnlSLHIITHLSFRPYNCKNPPC 424

                        410       420       430
                 ....*....|....*....|....*....|
gi 387848961 746 GKAFTIRSNLIKHQKIHTKQKPYKCSDLGK 775
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
430-803 6.15e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.57  E-value: 6.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 430 NPFICSECGKVFTHKTNLIIHQKIHTGERPYICTV--CGKAFTDRSNLIKHQKIHTGEKPYKCSD-CGKSFTWKSRLRIH 506
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKsLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 507 QKCHTGERHYECSECGKAFIQK---------STLSMHQRIHRGEKPYVCTEC-------------GKAFFHKSHFITHER 564
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRdpqlpdllsISNLRNNPLPGNNSSSVNTPQsnslhpplpanslSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 565 IHTGEKPYECSICGKSFTKKSQLHVHQQIHTGEKPYRCAECGKAFTD------RSNLFTHQKIHTGEKPYKCSDCGKAFT 638
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKsllsqsPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 639 RKSGLHIHQQSHTGERH-YECSECGKAFARKSTLIMHQR--IHTGE--KPYICNE--CGKSFIQKSHLNRHRRIHTGEKP 711
Cdd:COG5048  272 SSSPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 712 YEC--SDCGKSFIKKS-----QLHEHHRIHTGEKPYICA--ECGKAFTIRSNLIKHQKIHTKQKPYKCSDLGKALNWKPQ 782
Cdd:COG5048  352 AKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRH 431

                        410       420
                 ....*....|....*....|..
gi 387848961 783 LSM-PQKSDNGEVECSMPQLWC 803
Cdd:COG5048  432 YNLiPHKKIHTNHAPLLCSILK 453
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
318-702 1.90e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 318 KPYEYSECEKNLPQNSNLNIHKKIHTGGKHFECT--ECGKAFTRKSTLSMHQKIHTGEKPYVCT-ECGKAFIRKSHFITH 394
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 395 ERIHTGEKPYECSDCGKSFIKKSQLH------------VHQRIHTGENPFICS----------ECGKVFTHKTNLIIHQK 452
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLpdllsisnlrnnPLPGNNSSSVNTPQSnslhpplpanSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 453 IHTGERPYICTVCGKAFTDRSNLIKHQKIHTGEKPYKCSDCGKSFTWKSRLRIHQKCHTGERHYECSECGKAFIQKSTLS 532
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 533 MHQRIHRGE-------KPYVCTECGKAFFHKSHFITHER--IHTGE--KPYEC--SICGKSFTKKSQLHVHQQIHTGEKP 599
Cdd:COG5048  272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 600 YRC--AECGKAFTDRSN-----LFTHQKIHTGEKPYKCSD--CGKAFTRKSGLHIHQQSHTGERHYEC--SECGKAFARK 668
Cdd:COG5048  352 AKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRH 431

                        410       420       430
                 ....*....|....*....|....*....|....
gi 387848961 669 STLIMHQRIHTgEKPYICNECGKSFIQKSHLNRH 702
Cdd:COG5048  432 YNLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
KRAB smart00349
krueppel associated box;
1-31 2.78e-09

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 53.75  E-value: 2.78e-09
                           10        20        30
                   ....*....|....*....|....*....|..
gi 387848961     1 MLENYFNLISVGCQVPKPEVIFSLEQ-EEPCM 31
Cdd:smart00349  30 MLENYSNLVSLGFQVPKPDLISQLEQgEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
459-648 1.03e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.01  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 459 PYICTVCGKAFTDRSNLIKHQ--KIHTGE--KPYKC--SDCGKSFTWKSRLRIHQKCHTGERHYEC--SECGKAFIQKST 530
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLN 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 531 LSMHQRIHrgekpyvctecgkaffhksHFITHERIHTGEKPYECSICGKSFTKKSQLHVHQQIHTGEKPYRCAECGKAFT 610
Cdd:COG5048  369 NEPPQSLQ-------------------QYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFN 429

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 387848961 611 DRSNLFTHQKIHTGEKPYKCSDCGKAFTRKSGLHIHQQ 648
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
698-721 2.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.40e-04
                          10        20
                  ....*....|....*....|....
gi 387848961  698 HLNRHRRIHTGEKPYECSDCGKSF 721
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
614-639 4.82e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.82e-04
                          10        20
                  ....*....|....*....|....*.
gi 387848961  614 NLFTHQKIHTGEKPYKCSDCGKAFTR 639
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
474-498 5.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.81e-04
                          10        20
                  ....*....|....*....|....*
gi 387848961  474 NLIKHQKIHTGEKPYKCSDCGKSFT 498
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 598-650 1.29e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.31  E-value: 1.29e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 387848961 598 KPYrCAECGKAFTDRSNLFTHQKIHTgekpYKCSDCGKAFTRKSGLHIH-QQSH 650
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 624-703 1.64e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 624 GEKPYKCS--DCGKAFTRKSGLHIHQQshtgERHyecseCGKAFARKSTLIMHQRIHTGEKPYICNECGKSFIQKSHLNR 701
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML----HGH-----QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 387848961 702 HR 703
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
363-387 1.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.73e-03
                          10        20
                  ....*....|....*....|....*
gi 387848961  363 LSMHQKIHTGEKPYVCTECGKAFIR 387
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 684-706 2.03e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 2.03e-03
                          10        20
                  ....*....|....*....|...
gi 387848961  684 YICNECGKSFIQKSHLNRHRRIH 706
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
558-583 3.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.72e-03
                          10        20
                  ....*....|....*....|....*.
gi 387848961  558 HFITHERIHTGEKPYECSICGKSFTK 583
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 568-651 4.40e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 4.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 387848961 568 GEKPYECSI--CGKSFT-----KKSQLHVHQQIHTGEKPYrcaecgkafTDRSNLFTHQkihtgEKPYKCSDCGKAFTRK 640
Cdd:COG5189  346 DGKPYKCPVegCNKKYKnqnglKYHMLHGHQNQKLHENPS---------PEKMNIFSAK-----DKPYRCEVCDKRYKNL 411

                         90
                 ....*....|.
gi 387848961 641 SGLHIHQQSHT 651
Cdd:COG5189  412 NGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
531-555 4.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.70e-03
                          10        20
                  ....*....|....*....|....*
gi 387848961  531 LSMHQRIHRGEKPYVCTECGKAFFH 555
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
390-413 5.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.14e-03
                          10        20
                  ....*....|....*....|....
gi 387848961  390 HFITHERIHTGEKPYECSDCGKSF 413
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
334-359 6.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.83e-03
                          10        20
                  ....*....|....*....|....*.
gi 387848961  334 NLNIHKKIHTGGKHFECTECGKAFTR 359
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 460-482 7.49e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.49e-03
                          10        20
                  ....*....|....*....|...
gi 387848961  460 YICTVCGKAFTDRSNLIKHQKIH 482
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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