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Conserved domains on  [gi|392050772|ref|NP_001254708|]
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zinc finger protein 850 isoform 2 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 6-47 7.18e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 7.18e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 392050772     6 LVMFQDLSIDFSQEEWECLDAAQKDLYRDVMMENYSSLVSLD 47
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
499-915 1.63e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 80.51  E-value: 1.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  499 KPYHCKECGKSFTFRSGLIGHQAVHTGEKPYDC--KECGKSFTSRSALIQHQRIHTGEKPY-HCKECGKSFTVGSTLLQH 575
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  576 QQIHTGEKPYDCKECGKAFRLRLRLTQHQQIHTGEKPYQCQECGKAFVSVSGLT-QHHRIHTGEKPYECPDCGKAFRqrt 654
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNsLHPPLPANSLSKDPSSNLSLLI--- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  655 ylnqHRRIHTGEKPYECKECGKSFTFCSGLIQHQQNHTDEKPYDGKECGKSFTSHSTLIQHQQIHTGEKPYDCKECGKSF 734
Cdd:COG5048   189 ----SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  735 TSHSTLIQHQQIHTGE-------KLYDCKECGKSFTSHSTLIQHQP--LHTGE--KPYHCKE--CGKSFTLRSALIQHRP 801
Cdd:COG5048   265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  802 VHTGEKRYSCK--ECGKSFTSRST-----LIEHQRIHTGEKPYHC--KECGKSFAFRSAIIQHRRIHTGEKPYDCK--EC 870
Cdd:COG5048   345 LHTSISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 392050772  871 GKAFRRRSKLTQHQRIHTGEKPYRCHECGKAFVRFSglTKHHSIH 915
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD--LSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
211-627 2.30e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.49  E-value: 2.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  211 HQKMYTDERPHECQESVKAFRPSAHLIQHWRIHTGDKPYEC--KECGKSFTSGSTLNQHQQIHTGEKPYHCKQCG---KS 285
Cdd:COG5048    24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsNS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  286 FTVGSTL---------------------IRHQQIHTGEKPYD--CKECGKSFASGSALIRHQRIHtgeKPYDCKECGKSF 342
Cdd:COG5048   104 KASSSSLsssssnsndnnllsshslppsSRDPQLPDLLSISNlrNNPLPGNNSSSVNTPQSNSLH---PPLPANSLSKDP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  343 TFHSALIRHQRIHTGEKPYDCKECGKSFTFRSGLIGHQAIHTGEKPYDCKECGKSFTAGSTLIQHQRIHTGEKPYDCKEC 422
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  423 GKSF--ASGSALLQHQRIHTGE-----KPYCCKECGKSFTFRSTRNRHQR--IHTGE--KPYNCKE--CGKSFASGSALL 489
Cdd:COG5048   261 PRSSlpTASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  490 QHQRIHTGEKPYHCKECGKSFTFRSGLIGhqavhtgekpydckecgksftSRSALIQHQRIHTGEKPYHC--KECGKSFT 567
Cdd:COG5048   341 RHILLHTSISPAKEKLLNSSSKFSPLLNN---------------------EPPQSLQQYKDLKNDKKSETlsNSCIRNFK 399

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392050772  568 VGSTLLQHQQIHTGEKPYDCK--ECGKAFRLRLRLTQHQQIHTGEKPYQCQECGKAFVSVSG 627
Cdd:COG5048   400 RDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 973-1051 1.31e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  973 GEKPYDCK--ECGKAFRCPSQLSQHKRI-HTGEKTYQCPECGKaffyasglsrHQSVHTGEKPYECKTCGKAFKQLTQLT 1049
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ..
gi 392050772 1050 RH 1051
Cdd:COG5189   416 YH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
935-960 4.71e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.71e-03
                           10        20
                   ....*....|....*....|....*.
gi 392050772   935 HLTLHQRIHTGDRPYECKECGKSFTC 960
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 6-47 7.18e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 7.18e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 392050772     6 LVMFQDLSIDFSQEEWECLDAAQKDLYRDVMMENYSSLVSLD 47
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
7-50 1.33e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 86.11  E-value: 1.33e-20
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 392050772      7 VMFQDLSIDFSQEEWECLDAAQKDLYRDVMMENYSSLVSLDSEF 50
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQV 44
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 7-46 1.50e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 82.60  E-value: 1.50e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 392050772    7 VMFQDLSIDFSQEEWECLDAAQKDLYRDVMMENYSSLVSL 46
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
499-915 1.63e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 80.51  E-value: 1.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  499 KPYHCKECGKSFTFRSGLIGHQAVHTGEKPYDC--KECGKSFTSRSALIQHQRIHTGEKPY-HCKECGKSFTVGSTLLQH 575
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  576 QQIHTGEKPYDCKECGKAFRLRLRLTQHQQIHTGEKPYQCQECGKAFVSVSGLT-QHHRIHTGEKPYECPDCGKAFRqrt 654
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNsLHPPLPANSLSKDPSSNLSLLI--- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  655 ylnqHRRIHTGEKPYECKECGKSFTFCSGLIQHQQNHTDEKPYDGKECGKSFTSHSTLIQHQQIHTGEKPYDCKECGKSF 734
Cdd:COG5048   189 ----SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  735 TSHSTLIQHQQIHTGE-------KLYDCKECGKSFTSHSTLIQHQP--LHTGE--KPYHCKE--CGKSFTLRSALIQHRP 801
Cdd:COG5048   265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  802 VHTGEKRYSCK--ECGKSFTSRST-----LIEHQRIHTGEKPYHC--KECGKSFAFRSAIIQHRRIHTGEKPYDCK--EC 870
Cdd:COG5048   345 LHTSISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 392050772  871 GKAFRRRSKLTQHQRIHTGEKPYRCHECGKAFVRFSglTKHHSIH 915
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD--LSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
211-627 2.30e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.49  E-value: 2.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  211 HQKMYTDERPHECQESVKAFRPSAHLIQHWRIHTGDKPYEC--KECGKSFTSGSTLNQHQQIHTGEKPYHCKQCG---KS 285
Cdd:COG5048    24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsNS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  286 FTVGSTL---------------------IRHQQIHTGEKPYD--CKECGKSFASGSALIRHQRIHtgeKPYDCKECGKSF 342
Cdd:COG5048   104 KASSSSLsssssnsndnnllsshslppsSRDPQLPDLLSISNlrNNPLPGNNSSSVNTPQSNSLH---PPLPANSLSKDP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  343 TFHSALIRHQRIHTGEKPYDCKECGKSFTFRSGLIGHQAIHTGEKPYDCKECGKSFTAGSTLIQHQRIHTGEKPYDCKEC 422
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  423 GKSF--ASGSALLQHQRIHTGE-----KPYCCKECGKSFTFRSTRNRHQR--IHTGE--KPYNCKE--CGKSFASGSALL 489
Cdd:COG5048   261 PRSSlpTASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  490 QHQRIHTGEKPYHCKECGKSFTFRSGLIGhqavhtgekpydckecgksftSRSALIQHQRIHTGEKPYHC--KECGKSFT 567
Cdd:COG5048   341 RHILLHTSISPAKEKLLNSSSKFSPLLNN---------------------EPPQSLQQYKDLKNDKKSETlsNSCIRNFK 399

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392050772  568 VGSTLLQHQQIHTGEKPYDCK--ECGKAFRLRLRLTQHQQIHTGEKPYQCQECGKAFVSVSG 627
Cdd:COG5048   400 RDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
655-679 1.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 1.18e-03
                           10        20
                   ....*....|....*....|....*
gi 392050772   655 YLNQHRRIHTGEKPYECKECGKSFT 679
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 973-1051 1.31e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  973 GEKPYDCK--ECGKAFRCPSQLSQHKRI-HTGEKTYQCPECGKaffyasglsrHQSVHTGEKPYECKTCGKAFKQLTQLT 1049
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ..
gi 392050772 1050 RH 1051
Cdd:COG5189   416 YH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
963-988 2.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 2.08e-03
                           10        20
                   ....*....|....*....|....*.
gi 392050772   963 ELIRHQRTHTGEKPYDCKECGKAFRC 988
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
461-484 2.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.59e-03
                           10        20
                   ....*....|....*....|....
gi 392050772   461 NRHQRIHTGEKPYNCKECGKSFAS 484
Cdd:pfam13465    3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
935-960 4.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.71e-03
                           10        20
                   ....*....|....*....|....*.
gi 392050772   935 HLTLHQRIHTGDRPYECKECGKSFTC 960
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 863-911 9.36e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 9.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 392050772  863 KPYdCKECGKAFRRRSKLTQHQRIHTgekpYRCHECGKAFVRFSGLTKH 911
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 6-47 7.18e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 86.37  E-value: 7.18e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 392050772     6 LVMFQDLSIDFSQEEWECLDAAQKDLYRDVMMENYSSLVSLD 47
Cdd:pfam01352    1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
7-50 1.33e-20

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 86.11  E-value: 1.33e-20
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 392050772      7 VMFQDLSIDFSQEEWECLDAAQKDLYRDVMMENYSSLVSLDSEF 50
Cdd:smart00349    1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQV 44
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 7-46 1.50e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 82.60  E-value: 1.50e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 392050772    7 VMFQDLSIDFSQEEWECLDAAQKDLYRDVMMENYSSLVSL 46
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
499-915 1.63e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 80.51  E-value: 1.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  499 KPYHCKECGKSFTFRSGLIGHQAVHTGEKPYDC--KECGKSFTSRSALIQHQRIHTGEKPY-HCKECGKSFTVGSTLLQH 575
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  576 QQIHTGEKPYDCKECGKAFRLRLRLTQHQQIHTGEKPYQCQECGKAFVSVSGLT-QHHRIHTGEKPYECPDCGKAFRqrt 654
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNsLHPPLPANSLSKDPSSNLSLLI--- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  655 ylnqHRRIHTGEKPYECKECGKSFTFCSGLIQHQQNHTDEKPYDGKECGKSFTSHSTLIQHQQIHTGEKPYDCKECGKSF 734
Cdd:COG5048   189 ----SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  735 TSHSTLIQHQQIHTGE-------KLYDCKECGKSFTSHSTLIQHQP--LHTGE--KPYHCKE--CGKSFTLRSALIQHRP 801
Cdd:COG5048   265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  802 VHTGEKRYSCK--ECGKSFTSRST-----LIEHQRIHTGEKPYHC--KECGKSFAFRSAIIQHRRIHTGEKPYDCK--EC 870
Cdd:COG5048   345 LHTSISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 392050772  871 GKAFRRRSKLTQHQRIHTGEKPYRCHECGKAFVRFSglTKHHSIH 915
Cdd:COG5048   425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD--LSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
555-990 2.28e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 2.28e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  555 KPYHCKECGKSFTVGSTLLQHQQIHTGEKPYDC--KECGKAFRLRLRLTQHQQIHTGEKPY-QCQECGKAFVSVSGLTQH 631
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  632 HRIHTGEKPYECPDCGKAFRQRTYLNQHRRIHTGEKPYECKECGKSFTFCSG----LIQHQQNHTDEKPYDGKecgkSFT 707
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslHPPLPANSLSKDPSSNL----SLL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  708 SHSTLIQHQQIHTgekpydCKECGKSFTSHSTLIQHQQIHTGEKLYDCKECgkSFTSHSTLIQHQPLHTGEK--PYHCKE 785
Cdd:COG5048   188 ISSNVSTSIPSSS------ENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN--SQLSPKSLLSQSPSSLSSSdsSSSASE 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  786 CGKSFTLRSALIQHRPVHTGE-------KRYSCKECGKSFTSRSTLIEHQR--IHTGE--KPYHCKE--CGKSFAFRSAI 852
Cdd:COG5048   260 SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDAL 339

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  853 IQHRRIHTGEKPydckecgkafrRRSKLTQHQRIHTGEKPYRCHECgkafvrfsglTKHHSIHTGEKPYEC--KTCGKSF 930
Cdd:COG5048   340 KRHILLHTSISP-----------AKEKLLNSSSKFSPLLNNEPPQS----------LQQYKDLKNDKKSETlsNSCIRNF 398

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392050772  931 RQRTHLTLHQRIHTGDRPYECK--ECGKSFTCGSELIRHQRTHTGEKPYDCKECGKAFRCPS 990
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
639-1055 1.83e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.88  E-value: 1.83e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  639 KPYECPDCGKAFRQRTYLNQHRRIHTGEKPYEC--KECGKSFTFCSGLIQHQQNHTDEKPYDgkECGKSFTSHSTLIQHQ 716
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDL--NSKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  717 QIHTGEKP-YDCKECGKSFTSHSTLIQHQQIHTgEKLYDCKECGKSFTSHSTLIQHQPLHtGEKPYHCKECGKSFTLRSA 795
Cdd:COG5048   110 LSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLS-ISNLRNNPLPGNNSSSVNTPQSNSLH-PPLPANSLSKDPSSNLSLL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  796 LiqHRPVHTGEKRYSCKECGKSFTSRSTLIEHQRIHTGEKPYHCKECGKSFAFRSAIIQHRRIHTGEKPYDCKECGKAFR 875
Cdd:COG5048   188 I--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  876 --RRSKLTQHQRIHTGE-----KPYRCHECGKAFVRFSGLTKH--HSIHTGE--KPYEC--KTCGKSFRQRTHLTLHQRI 942
Cdd:COG5048   266 ptASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  943 HTGDRPYECKecgksftcgseLIRHQRTHTGEKPYdckecgkafrCPSQLSQHKRIHTGEKTYQC--PECGKAFFYASGL 1020
Cdd:COG5048   346 HTSISPAKEK-----------LLNSSSKFSPLLNN----------EPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNL 404

                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 392050772 1021 SRHQSVHTGEKPYECK--TCGKAFKQLTQLTRHQRIH 1055
Cdd:COG5048   405 SLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
211-627 2.30e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.49  E-value: 2.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  211 HQKMYTDERPHECQESVKAFRPSAHLIQHWRIHTGDKPYEC--KECGKSFTSGSTLNQHQQIHTGEKPYHCKQCG---KS 285
Cdd:COG5048    24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsNS 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  286 FTVGSTL---------------------IRHQQIHTGEKPYD--CKECGKSFASGSALIRHQRIHtgeKPYDCKECGKSF 342
Cdd:COG5048   104 KASSSSLsssssnsndnnllsshslppsSRDPQLPDLLSISNlrNNPLPGNNSSSVNTPQSNSLH---PPLPANSLSKDP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  343 TFHSALIRHQRIHTGEKPYDCKECGKSFTFRSGLIGHQAIHTGEKPYDCKECGKSFTAGSTLIQHQRIHTGEKPYDCKEC 422
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  423 GKSF--ASGSALLQHQRIHTGE-----KPYCCKECGKSFTFRSTRNRHQR--IHTGE--KPYNCKE--CGKSFASGSALL 489
Cdd:COG5048   261 PRSSlpTASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  490 QHQRIHTGEKPYHCKECGKSFTFRSGLIGhqavhtgekpydckecgksftSRSALIQHQRIHTGEKPYHC--KECGKSFT 567
Cdd:COG5048   341 RHILLHTSISPAKEKLLNSSSKFSPLLNN---------------------EPPQSLQQYKDLKNDKKSETlsNSCIRNFK 399

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392050772  568 VGSTLLQHQQIHTGEKPYDCK--ECGKAFRLRLRLTQHQQIHTGEKPYQCQECGKAFVSVSG 627
Cdd:COG5048   400 RDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
331-762 4.31e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.72  E-value: 4.31e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  331 KPYDCKECGKSFTFHSALIRHQRIHTGEKPYDCKECGksftfrsglighqaihtgekpydckeCGKSFTAGSTLIQHQRI 410
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSG--------------------------CDKSFSRPLELSRHLRT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  411 HTGEKPYDCKECGKSFASGSALLQHQRIHTG---EKPYCCKECGKSFTFRSTRNRHQRIHtgekpYNCKECGKSFASGSA 487
Cdd:COG5048    86 HHNNPSDLNSKSLPLSNSKASSSSLSSSSSNsndNNLLSSHSLPPSSRDPQLPDLLSISN-----LRNNPLPGNNSSSVN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  488 LLQHQRIHtGEKPYHCKeCGKSFTFRSGLIGHQAVHTGEKPYDCKEcGKSFTSRSALIQHQRIHTGEKPYHCKECGKSFT 567
Cdd:COG5048   161 TPQSNSLH-PPLPANSL-SKDPSSNLSLLISSNVSTSIPSSSENSP-LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSP 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  568 VGSTLLQHQQIHTGEKPYDCKECGKAFRLRLRLTQHQQIHTGE-------KPYQCQECGKAFvSVSGLTQHH---RIHTG 637
Cdd:COG5048   238 KSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISF-SRSSPLTRHlrsVNHSG 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  638 E--KPYECP--DCGKAFRQRTYLNQHRRIHTGEKPYECK--ECGKSFTFCSG--LIQHQQNHTDEKPY-----DGKECGK 704
Cdd:COG5048   317 EslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNnePPQSLQQYKDLKNDkksetLSNSCIR 396

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  705 SFTSHSTLIQHQQIHTGEKPYDCK--ECGKSFTSHSTLIQHQQIHTGEKLYDCKECGKSF 762
Cdd:COG5048   397 NFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
118-547 1.01e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.02  E-value: 1.01e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  118 TFCLQTSLTLHHRIHPGEKLYKSTECMAFKYGS---ELTQQQETHTGEKlykckecgkafhhfSYLVKHQRIHTGEKPCA 194
Cdd:COG5048    42 SFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrplELSRHLRTHHNNP--------------SDLNSKSLPLSNSKASS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  195 CKEYGKAFISGSHLIQHQKMYTDERPHEcqesvkaFRPSAHLIQHWRihtgdkPYECKECGKSF--TSGSTLNQHQqiht 272
Cdd:COG5048   108 SSLSSSSSNSNDNNLLSSHSLPPSSRDP-------QLPDLLSISNLR------NNPLPGNNSSSvnTPQSNSLHPP---- 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  273 geKPYHCKQcgKSFTVGSTLIRHQQIHTGEKPYDCKECGKSFASGSALIRHQRIHTGEKPYDCKECGKSFTFHSALIRHQ 352
Cdd:COG5048   171 --LPANSLS--KDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPS 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  353 RIHTGEKPYDCKECGKSFTFRSGLIGHQAIHTGE-------KPYDCKECGKSFTAGSTLIQHQR--IHTGE--KPYDCKE 421
Cdd:COG5048   247 SLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPY 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  422 --CGKSFASGSALLQHQRIHTGEKPYCCK--ECGKSFTFRSTRNRHQRIH-----TGEKPYNC--KECGKSFASGSALLQ 490
Cdd:COG5048   327 slCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSL 406

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 392050772  491 HQRIHTGEKPYHCK--ECGKSFTFRSGLIGHQAVHTGEKPYDCkeCGKSFTSRSALIQH 547
Cdd:COG5048   407 HIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
211-464 6.15e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 6.15e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  211 HQKMYTDERPHECQESVKAFRPSAHLIQHWRIHTGDKPYECKECGKSFTSGSTLNQHQQIHTGEKPYHCKQCGKSFTVGS 290
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  291 TLIRHQQIHTGE-------KPYDCKECGKSFASGSALIRHQR--IHTGE--KPYDCKE--CGKSFTFHSALIRHQRIHTG 357
Cdd:COG5048   269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  358 EKPYDCKECGKSFTFRSGLIG-------HQAIHTGEKPYDC--KECGKSFTAGSTLIQHQRIHTGEKPYDCK--ECGKSF 426
Cdd:COG5048   349 ISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 392050772  427 ASGSALLQHQRIHTGEKPYCCKECGKSFTFRSTRNRHQ 464
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
763-1058 6.24e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 6.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  763 TSHSTLIQHQPLHTGE----KPYHCKECGKSFTLRSALIQHRPVHTGEKRYSC--KECGKSFTSRSTLIEHQRIHTGEKP 836
Cdd:COG5048    12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  837 Y-HCKECGKSFAFRSAIIQHRRIHTGEKPYDCKECGKAFRRRSKLTQHQRIHTGEKPYRCHECGKAFVRFSGLTKHHSIH 915
Cdd:COG5048    92 DlNSKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  916 TGEKPYECKTCGKSFrqrthlTLHQRIHTGDRPYECKECGKSFTCGSELIRHQRTHTGEKPYDCKECGKAFRCPSQLSQH 995
Cdd:COG5048   172 PANSLSKDPSSNLSL------LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSP 245

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  996 KRIHTGEKTYQCPECGKAFFYASGLSRHQSVHTGE-------KPYECKTCGKAFKQLTQLTRHQRIHDLT 1058
Cdd:COG5048   246 SSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVNHS 315
zf-H2C2_2 pfam13465
Zinc-finger double domain;
655-679 1.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 1.18e-03
                           10        20
                   ....*....|....*....|....*
gi 392050772   655 YLNQHRRIHTGEKPYECKECGKSFT 679
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 973-1051 1.31e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  973 GEKPYDCK--ECGKAFRCPSQLSQHKRI-HTGEKTYQCPECGKaffyasglsrHQSVHTGEKPYECKTCGKAFKQLTQLT 1049
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ..
gi 392050772 1050 RH 1051
Cdd:COG5189   416 YH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
487-511 1.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.37e-03
                           10        20
                   ....*....|....*....|....*
gi 392050772   487 ALLQHQRIHTGEKPYHCKECGKSFT 511
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 609-693 1.40e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392050772  609 GEKPYQCQ--ECGKAFVSVSGLtQHHRI--HTGEKPYECPDCGKafrqrtylnqHRRIHTGEKPYECKECGKSFTFCSGL 684
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGL-KYHMLhgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGL 414


                  ....*....
gi 392050772  685 IQHQQNHTD 693
Cdd:COG5189   415 KYHRKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
880-904 1.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.55e-03
                           10        20
                   ....*....|....*....|....*
gi 392050772   880 LTQHQRIHTGEKPYRCHECGKAFVR 904
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
543-567 1.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.71e-03
                           10        20
                   ....*....|....*....|....*
gi 392050772   543 ALIQHQRIHTGEKPYHCKECGKSFT 567
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
963-988 2.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 2.08e-03
                           10        20
                   ....*....|....*....|....*.
gi 392050772   963 ELIRHQRTHTGEKPYDCKECGKAFRC 988
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
461-484 2.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.59e-03
                           10        20
                   ....*....|....*....|....
gi 392050772   461 NRHQRIHTGEKPYNCKECGKSFAS 484
Cdd:pfam13465    3 KRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
347-371 2.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.66e-03
                           10        20
                   ....*....|....*....|....*
gi 392050772   347 ALIRHQRIHTGEKPYDCKECGKSFT 371
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
319-343 2.66e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.66e-03
                           10        20
                   ....*....|....*....|....*
gi 392050772   319 ALIRHQRIHTGEKPYDCKECGKSFT 343
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
628-652 3.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 3.06e-03
                           10        20
                   ....*....|....*....|....*
gi 392050772   628 LTQHHRIHTGEKPYECPDCGKAFRQ 652
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
824-847 3.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.34e-03
                           10        20
                   ....*....|....*....|....
gi 392050772   824 LIEHQRIHTGEKPYHCKECGKSFA 847
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
431-455 3.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.79e-03
                           10        20
                   ....*....|....*....|....*
gi 392050772   431 ALLQHQRIHTGEKPYCCKECGKSFT 455
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
404-428 4.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.35e-03
                           10        20
                   ....*....|....*....|....*
gi 392050772   404 LIQHQRIHTGEKPYDCKECGKSFAS 428
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
264-287 4.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.53e-03
                           10        20
                   ....*....|....*....|....
gi 392050772   264 LNQHQQIHTGEKPYHCKQCGKSFT 287
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
992-1014 4.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.62e-03
                           10        20
                   ....*....|....*....|...
gi 392050772   992 LSQHKRIHTGEKTYQCPECGKAF 1014
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
935-960 4.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.71e-03
                           10        20
                   ....*....|....*....|....*.
gi 392050772   935 HLTLHQRIHTGDRPYECKECGKSFTC 960
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
599-624 6.91e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 6.91e-03
                           10        20
                   ....*....|....*....|....*.
gi 392050772   599 RLTQHQQIHTGEKPYQCQECGKAFVS 624
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
292-316 8.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 8.08e-03
                           10        20
                   ....*....|....*....|....*
gi 392050772   292 LIRHQQIHTGEKPYDCKECGKSFAS 316
Cdd:pfam13465    2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 863-911 9.36e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.38  E-value: 9.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 392050772  863 KPYdCKECGKAFRRRSKLTQHQRIHTgekpYRCHECGKAFVRFSGLTKH 911
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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