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Conserved domains on  [gi|392996933|ref|NP_001255214|]
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volume-regulated anion channel subunit LRRC8E isoform 2 [Homo sapiens]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 11673906)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like super family cl13911
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-202 7.02e-113

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


The actual alignment was detected with superfamily member pfam12534:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 343.06  E-value: 7.02e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933    1 MVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENQKGPAATERAAATIVAMA-----GTGPGKAGEGEKE 75
Cdd:pfam12534 138 MVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPKVSsssslSSSDESAPLTRTP 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933   76 KVLAEPEKVVTE-PPVVTLLDKKEGEQAKALFEKVKKFRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFL 154
Cdd:pfam12534 218 SVKSSPEKPVVEvPSTVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFT 297

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 392996933  155 VACRVETSEVTGYASFCCNHTKAHLFSKLAFCYISFVCIYGLTCIYTL 202
Cdd:pfam12534 298 VDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
392-643 3.52e-34

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.06  E-value: 3.52e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 392 ELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLerIPHA 471
Cdd:COG4886   14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL--GLTD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 472 VFSLGALQELDLKDNhlrsieeiLSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRL 551
Cdd:COG4886   92 LGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKS 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 552 LDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEAL 631
Cdd:COG4886  164 LDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                        250
                 ....*....|..
gi 392996933 632 PeELGNCGGLKK 643
Cdd:COG4886  244 P-ELGNLTNLEE 254
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-202 7.02e-113

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 343.06  E-value: 7.02e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933    1 MVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENQKGPAATERAAATIVAMA-----GTGPGKAGEGEKE 75
Cdd:pfam12534 138 MVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPKVSsssslSSSDESAPLTRTP 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933   76 KVLAEPEKVVTE-PPVVTLLDKKEGEQAKALFEKVKKFRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFL 154
Cdd:pfam12534 218 SVKSSPEKPVVEvPSTVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFT 297

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 392996933  155 VACRVETSEVTGYASFCCNHTKAHLFSKLAFCYISFVCIYGLTCIYTL 202
Cdd:pfam12534 298 VDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
392-643 3.52e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.06  E-value: 3.52e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 392 ELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLerIPHA 471
Cdd:COG4886   14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL--GLTD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 472 VFSLGALQELDLKDNhlrsieeiLSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRL 551
Cdd:COG4886   92 LGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKS 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 552 LDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEAL 631
Cdd:COG4886  164 LDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                        250
                 ....*....|..
gi 392996933 632 PeELGNCGGLKK 643
Cdd:COG4886  244 P-ELGNLTNLEE 254
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 478-626 5.45e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 83.30  E-value: 5.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 478 LQELDLKDNHLRSIEeilSFQHCRKLVTLRLWHNQIAYVpEHVRKLRSLEQLYLSYNKLETLpSQLGLCSGLRLLDVSHN 557
Cdd:cd21340   26 LKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 558 glhSLPPEV----------GLLQNLQHLALSYNALEALpEELFFCRKLRTLLLGDNQLS---QLSPHVGALRALSRLELK 624
Cdd:cd21340  101 ---RLPPGEkltfdprslaALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleELLDLLSSWPSLRELDLT 176


                 ..
gi 392996933 625 GN 626
Cdd:cd21340  177 GN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
457-635 1.32e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.43  E-value: 1.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 457 ELELVACGLERIPHAV--------------FSL-----GALQELDLKDNHLRSIEEILSfqhcRKLVTLRLWHNQIAYVP 517
Cdd:PRK15370 182 ELRLKILGLTTIPACIpeqittlildnnelKSLpenlqGNIKTLYANSNQLTSIPATLP----DTIQEMELSINRITELP 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 518 EHVRKlrSLEQLYLSYNKLETLPSQLGlcSGLRLLDVSHNGLHSLPPEvgLLQNLQHLALSYNALEALPEELffCRKLRT 597
Cdd:PRK15370 258 ERLPS--ALQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAH--LPSGITHLNVQSNSLTALPETL--PPGLKT 329

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 392996933 598 LLLGDNQLSQLSPHVGAlrALSRLELKGNRLEALPEEL 635
Cdd:PRK15370 330 LEAGENALTSLPASLPP--ELQVLDVSKNQITVLPETL 365
LRR_8 pfam13855
Leucine rich repeat;
547-605 4.99e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 4.99e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392996933  547 SGLRLLDVSHNGLHSLPPEVGL-LQNLQHLALSYNALEALPEELFFC-RKLRTLLLGDNQL 605
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-202 7.02e-113

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 343.06  E-value: 7.02e-113
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933    1 MVCTSFWFKFPGTSSKIEHFISILGKCFDSPWTTRALSEVSGENQKGPAATERAAATIVAMA-----GTGPGKAGEGEKE 75
Cdd:pfam12534 138 MVSSNFWFKFPGTSSKIEHFVSILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPKVSsssslSSSDESAPLTRTP 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933   76 KVLAEPEKVVTE-PPVVTLLDKKEGEQAKALFEKVKKFRMHVEEGDILYTMYIRQTVLKVCKFLAILVYNLVYVEKISFL 154
Cdd:pfam12534 218 SVKSSPEKPVVEvPSTVSVLDKKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFT 297

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 392996933  155 VACRVETSEVTGYASFCCNHTKAHLFSKLAFCYISFVCIYGLTCIYTL 202
Cdd:pfam12534 298 VDCKPDIEALTGYSRFYCNHNLAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
392-643 3.52e-34

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.06  E-value: 3.52e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 392 ELARAATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLerIPHA 471
Cdd:COG4886   14 LLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL--GLTD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 472 VFSLGALQELDLKDNhlrsieeiLSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRL 551
Cdd:COG4886   92 LGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKS 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 552 LDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEAL 631
Cdd:COG4886  164 LDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                        250
                 ....*....|..
gi 392996933 632 PeELGNCGGLKK 643
Cdd:COG4886  244 P-ELGNLTNLEE 254
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
222-592 1.68e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 1.68e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 222 TGMGDIPDVKNDFAFMLHLIDQYDSLYSKRFAVFLSEVSESRLKQLNLNHEWTPEKLRQKLQRNAAGRLELALCMLPGLP 301
Cdd:COG4886   10 LKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 302 DTVFELSEVESLrleaicDITFPPGLSQLVHLQELSLLHSparlpfslqvflrdhlkvmrvkceELREVPLWVFGLRGLE 381
Cdd:COG4886   90 TDLGDLTNLTEL------DLSGNEELSNLTNLESLDLSGN------------------------QLTDLPEELANLTNLK 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 382 ELHLEGLFPQELAraatlESLRELKQLKVLSLRSNA-GKVPASVTDVAgHLQRLSLHNDgaRLVAL-NSLKKLAALRELE 459
Cdd:COG4886  140 ELDLSNNQLTDLP-----EPLGNLTNLKSLDLSNNQlTDLPEELGNLT-NLKELDLSNN--QITDLpEPLGNLTNLEELD 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 460 LVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQhcrKLVTLRLWHNQIAYVPEhVRKLRSLEQLYLSYNKLETL 539
Cdd:COG4886  212 LSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLT---NLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDL 287

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 392996933 540 P-SQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFC 592
Cdd:COG4886  288 KlKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 478-626 5.45e-18

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 83.30  E-value: 5.45e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 478 LQELDLKDNHLRSIEeilSFQHCRKLVTLRLWHNQIAYVpEHVRKLRSLEQLYLSYNKLETLpSQLGLCSGLRLLDVSHN 557
Cdd:cd21340   26 LKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIENQ 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 558 glhSLPPEV----------GLLQNLQHLALSYNALEALpEELFFCRKLRTLLLGDNQLS---QLSPHVGALRALSRLELK 624
Cdd:cd21340  101 ---RLPPGEkltfdprslaALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleELLDLLSSWPSLRELDLT 176


                 ..
gi 392996933 625 GN 626
Cdd:cd21340  177 GN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
457-635 1.32e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 77.43  E-value: 1.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 457 ELELVACGLERIPHAV--------------FSL-----GALQELDLKDNHLRSIEEILSfqhcRKLVTLRLWHNQIAYVP 517
Cdd:PRK15370 182 ELRLKILGLTTIPACIpeqittlildnnelKSLpenlqGNIKTLYANSNQLTSIPATLP----DTIQEMELSINRITELP 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 518 EHVRKlrSLEQLYLSYNKLETLPSQLGlcSGLRLLDVSHNGLHSLPPEvgLLQNLQHLALSYNALEALPEELffCRKLRT 597
Cdd:PRK15370 258 ERLPS--ALQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAH--LPSGITHLNVQSNSLTALPETL--PPGLKT 329

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 392996933 598 LLLGDNQLSQLSPHVGAlrALSRLELKGNRLEALPEEL 635
Cdd:PRK15370 330 LEAGENALTSLPASLPP--ELQVLDVSKNQITVLPETL 365
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 405-628 2.24e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 73.73  E-value: 2.24e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 405 LKQLKVLSLRSNA--GKVPASVTDVAGHLQRLSLHNDG-ARLVALNSLKKLAALRELELVACGleRIPHAVFSLGALQEL 481
Cdd:PLN00113  92 LPYIQTINLSNNQlsGPIPDDIFTTSSSLRYLNLSNNNfTGSIPRGSIPNLETLDLSNNMLSG--EIPNDIGSFSSLKVL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 482 DLKDNHLrsIEEI-LSFQHCRKLVTLRLWHNQ-IAYVPEHVRKLRSLEQLYLSYNKLE-TLPSQLGLCSGLRLLDVSHNG 558
Cdd:PLN00113 170 DLGGNVL--VGKIpNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVYNN 247

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392996933 559 LH-SLPPEVGLLQNLQHLALSYNALEA-LPEELFFCRKLRTLLLGDNQLSQLSPH-VGALRALSRLELKGNRL 628
Cdd:PLN00113 248 LTgPIPSSLGNLKNLQYLFLYQNKLSGpIPPSIFSLQKLISLDLSDNSLSGEIPElVIQLQNLEILHLFSNNF 320
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 370-637 6.94e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 68.72  E-value: 6.94e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 370 VPLWVFGLRGLEEL-----HLEGLFPQELAraatleslrELKQLKVLSLRSN--AGKVPASVTDVAgHLQRLSLHNDGAR 442
Cdd:PLN00113 276 IPPSIFSLQKLISLdlsdnSLSGEIPELVI---------QLQNLEILHLFSNnfTGKIPVALTSLP-RLQVLQLWSNKFS 345

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 443 LVALNSLKKLAALRELELVACGLE-RIPHAVFSLGALQELDLKDNHLRSiEEILSFQHCRKLVTLRLWHNQIA-YVPEHV 520
Cdd:PLN00113 346 GEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEG-EIPKSLGACRSLRRVRLQDNSFSgELPSEF 424

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 521 RKLR------------------------SLEQLYLSYNK-LETLPSQLGlCSGLRLLDVSHNGLH-SLPPEVGLLQNLQH 574
Cdd:PLN00113 425 TKLPlvyfldisnnnlqgrinsrkwdmpSLQMLSLARNKfFGGLPDSFG-SKRLENLDLSRNQFSgAVPRKLGSLSELMQ 503

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392996933 575 LALSYNALEA-LPEELFFCRKLRTLLLGDNQLS-QLSPHVGALRALSRLELKGNRLEA-LPEELGN 637
Cdd:PLN00113 504 LKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSGeIPKNLGN 569
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
502-660 2.31e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 63.95  E-value: 2.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 502 KLVTLRLWHNQIAYVPEHVRKlrSLEQLYLSYNKLETLPSQLGlcSGLRLLDVSHNGLHSLPPEvgLLQNLQHLALSYNA 581
Cdd:PRK15370 200 QITTLILDNNELKSLPENLQG--NIKTLYANSNQLTSIPATLP--DTIQEMELSINRITELPER--LPSALQSLDLFHNK 273

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392996933 582 LEALPEELffCRKLRTLLLGDNQLSQLSPHVGAlrALSRLELKGNRLEALPEELGNcgGLKKagLLVEDTLYQGLPAEV 660
Cdd:PRK15370 274 ISCLPENL--PEELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLPP--GLKT--LEAGENALTSLPASL 344
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 344-606 1.04e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 57.88  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 344 RLPFSLQVFLRDHlKVMRVKCEELREVPLWVFGLRGLEEL---------HLEGLFPQELARAATLESLRELKQLKVLSLR 414
Cdd:COG5238   62 YLRFEGQGDPGLN-PVALEKAAEAFPTQLLVVDWEGAEEVspvalaetaTAVATPPPDLRRIMAKTLEDSLILYLALPRR 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 415 SNagkVPASVTDVAG-HLQRLSLHNDGARLVALNSLKKLAALRELELVAC--------GLERIPHAVFSLGALQELDLKD 485
Cdd:COG5238  141 IN---LIQVLKDPLGgNAVHLLGLAARLGLLAAISMAKALQNNSVETVYLgcnqigdeGIEELAEALTQNTTVTTLWLKR 217

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 486 NHL--RSIEEILS-FQHCRKLVTLRLWHNQI-----AYVPEHVRKLRSLEQLYLSYNKL-----ETLPSQLGLCSGLRLL 552
Cdd:COG5238  218 NPIgdEGAEILAEaLKGNKSLTTLDLSNNQIgdegvIALAEALKNNTTVETLYLSGNQIgaegaIALAKALQGNTTLTSL 297

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392996933 553 DVSHNGLhSLPPEVGLLQNLQH------LALSYNAL-----EALPEELFFCRKLRTLLLGDNQLS 606
Cdd:COG5238  298 DLSVNRI-GDEGAIALAEGLQGnktlhtLNLAYNGIgaqgaIALAKALQENTTLHSLDLSDNQIG 361
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 468-564 2.61e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.17  E-value: 2.61e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 468 IPHAVFSLGALQELDLKDNHLRS-IEEILSfqHCRKLVTLRLWHNQIA-YVPEHVRKLRSLEQLYLSYNKLE-TLPSQLG 544
Cdd:PLN00113 491 VPRKLGSLSELMQLKLSENKLSGeIPDELS--SCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLG 568

                         90       100
                 ....*....|....*....|.
gi 392996933 545 LCSGLRLLDVSHNGLH-SLPP 564
Cdd:PLN00113 569 NVESLVQVNISHNHLHgSLPS 589
LRR_8 pfam13855
Leucine rich repeat;
547-605 4.99e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 4.99e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392996933  547 SGLRLLDVSHNGLHSLPPEVGL-LQNLQHLALSYNALEALPEELFFC-RKLRTLLLGDNQL 605
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
399-589 2.40e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 2.40e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 399 LESLRELKQ--LKVLSLRSNA-GKVPASVTDVaghLQRLSLhnDGARLVALNSlKKLAALRELELVACGLERIPHAVFSl 475
Cdd:PRK15370 211 LKSLPENLQgnIKTLYANSNQlTSIPATLPDT---IQEMEL--SINRITELPE-RLPSALQSLDLFHNKISCLPENLPE- 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 476 gALQELDLKDNHLRSIEEILSfqhcRKLVTLRLWHNQIAYVPEHVRKlrSLEQLYLSYNKLETLPSQL------------ 543
Cdd:PRK15370 284 -ELRYLSVYDNSIRTLPAHLP----SGITHLNVQSNSLTALPETLPP--GLKTLEAGENALTSLPASLppelqvldvskn 356

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 392996933 544 -------GLCSGLRLLDVSHNGLHSLPPEvgLLQNLQHLALSYNALEALPEEL 589
Cdd:PRK15370 357 qitvlpeTLPPTITTLDVSRNALTNLPEN--LPAALQIMQASRNNLVRLPESL 407
LRR_8 pfam13855
Leucine rich repeat;
570-628 1.44e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.44e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392996933  570 QNLQHLALSYNALEALPEELFF-CRKLRTLLLGDNQLSQLSPHVGA-LRALSRLELKGNRL 628
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
477-628 1.50e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 51.70  E-value: 1.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 477 ALQELDLKDNHLRSIEEILSfqhcrKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQL------------- 543
Cdd:PRK15387 303 GLQELSVSDNQLASLPALPS-----ELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELyklwaynnrltsl 377

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 544 -GLCSGLRLLDVSHNGLHSLPPevgLLQNLQHLALSYNALEALPeelFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLE 622
Cdd:PRK15387 378 pALPSGLKELIVSGNRLTSLPV---LPSELKELMVSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLSSETTVN 451


                 ....*.
gi 392996933 623 LKGNRL 628
Cdd:PRK15387 452 LEGNPL 457
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 376-539 4.03e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.24  E-value: 4.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 376 GLRGLEELHLEGlfpQELARAATLESLRELKQLKVLSLRSNAGKV----PASVTDVAGHLQRLSLHNDGarlvaLNSLKK 451
Cdd:cd21340   66 NLVNLKKLYLGG---NRISVVEGLENLTNLEELHIENQRLPPGEKltfdPRSLAALSNSLRVLNISGNN-----IDSLEP 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 452 LAALRELElvacgleriphavfslgalqELDLKDNHLRSIEEIL-SFQHCRKLVTLRLWHNQIAyvpeHVRKLRslEQLY 530
Cdd:cd21340  138 LAPLRNLE--------------------QLDASNNQISDLEELLdLLSSWPSLRELDLTGNPVC----KKPKYR--DKII 191


                 ....*....
gi 392996933 531 LSYNKLETL 539
Cdd:cd21340  192 LASKSLEVL 200
PLN03150 PLN03150
hypothetical protein; Provisional
 515-582 4.66e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 49.81  E-value: 4.66e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 515 YVPEHVRKLRSLEQLYLSYNKLE-TLPSQLGLCSGLRLLDVSHNGLH-SLPPEVGLLQNLQHLALSYNAL 582
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
LRR_8 pfam13855
Leucine rich repeat;
455-513 1.10e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.10e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933  455 LRELELVACGLERIPHAVFS-LGALQELDLKDNHLRSIEEIlSFQHCRKLVTLRLWHNQI 513
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPG-AFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
501-559 1.17e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.17e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392996933  501 RKLVTLRLWHNQIAYVPEHV-RKLRSLEQLYLSYNKLETL-PSQLGLCSGLRLLDVSHNGL 559
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 391-606 5.34e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.81  E-value: 5.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 391 QELARAATLESLRELKQLKVLSLRSNagkvpasvtdvaghlqrlSLHNDGARLVAlNSLKKLAALRELELVACGLERIPH 470
Cdd:cd00116    8 ELLKTERATELLPKLLCLQVLRLEGN------------------TLGEEAAKALA-SALRPQPSLKELCLSLNETGRIPR 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 471 AVFSLG-------ALQELDLKDNHLrSIEEILSFQHCRKLVTLRLWH-NQIAYVPEHVRKL--------RSLEQLYLSYN 534
Cdd:cd00116   69 GLQSLLqgltkgcGLQELDLSDNAL-GPDGCGVLESLLRSSSLQELKlNNNGLGDRGLRLLakglkdlpPALEKLVLGRN 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 535 KL-----ETLPSQLGLCSGLRLLDVSHN-----GLHSLPPEVGLLQNLQHLALSYNALE-----ALPEELFFCRKLRTLL 599
Cdd:cd00116  148 RLegascEALAKALRANRDLKELNLANNgigdaGIRALAEGLKANCNLEVLDLNNNGLTdegasALAETLASLKSLEVLN 227


                 ....*..
gi 392996933 600 LGDNQLS 606
Cdd:cd00116  228 LGDNNLT 234
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 455-632 9.83e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 42.55  E-value: 9.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933  455 LRELELVACGLERIPHAVFSLGALQELDLKDNhlRSIEEILSFQHCRKLVTLRLWH-NQIAYVPEHVRKLRSLEQLYLSY 533
Cdd:PLN03210  613 LVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGS--KNLKEIPDLSMATNLETLKLSDcSSLVELPSSIQYLNKLEDLDMSR 690

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933  534 -NKLETLPSQLGL----------CSGLRL----------LDVSHNGLHSLPPEVGlLQNLQHLALSYNALEALPEELFFC 592
Cdd:PLN03210  691 cENLEILPTGINLkslyrlnlsgCSRLKSfpdistniswLDLDETAIEEFPSNLR-LENLDELILCEMKSEKLWERVQPL 769

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 392996933  593 RKLRTLL--------LGDNQ-LSQLSPHVGALRALSRLELKGNR-LEALP 632
Cdd:PLN03210  770 TPLMTMLspsltrlfLSDIPsLVELPSSIQNLHKLEHLEIENCInLETLP 819
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 477-622 1.13e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392996933 477 ALQELDLKDNHLRSIEEIL-----SFQHCRKLVTLRLWHNQI----AYVPEHVRKLRSLEQLYLSYNKLETLPSQLgLCS 547
Cdd:cd00116   52 SLKELCLSLNETGRIPRGLqsllqGLTKGCGLQELDLSDNALgpdgCGVLESLLRSSSLQELKLNNNGLGDRGLRL-LAK 130

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392996933 548 GLRlldvshnglhSLPPEVGLLQnLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLS-QLSPHVG-ALRALSRLE 622
Cdd:cd00116  131 GLK----------DLPPALEKLV-LGRNRLEGASCEALAKALRANRDLKELNLANNGIGdAGIRALAeGLKANCNLE 196
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 569-643 1.53e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 1.53e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392996933 569 LQNLQHLALSYNALEALpEELFFCRKLRTLLLGDNQLSQLsPHVGALRALSRLELKGNRLEALpEELGNCGGLKK 643
Cdd:cd21340    1 LKRITHLYLNDKNITKI-DNLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKK 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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