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Conserved domains on  [gi|404351626|ref|NP_001258214|]
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adenine nucleotide translocase lysine N-methyltransferase isoform 2 [Homo sapiens]

Protein Classification

METTL5 family protein( domain architecture ID 1904007)

METTL5 family protein similar to Homo sapiens methyltransferase-like protein 5 that is a catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2263 super family cl43663
Predicted RNA methylase [General function prediction only];
74-123 9.54e-05

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG2263:

Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 41.81  E-value: 9.54e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 404351626  74 GRPGKTV-DLGSGDGRIVLAAHRCGLRPAVGYELNPWLVALARLHAWRAGC 123
Cdd:COG2263   43 DIEGKTVlDLGCGTGMLAIGAALLGAKKVVGVDIDPEALEIARENAERLGV 93
 
Name Accession Description Interval E-value
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
74-123 9.54e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 41.81  E-value: 9.54e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 404351626  74 GRPGKTV-DLGSGDGRIVLAAHRCGLRPAVGYELNPWLVALARLHAWRAGC 123
Cdd:COG2263   43 DIEGKTVlDLGCGTGMLAIGAALLGAKKVVGVDIDPEALEIARENAERLGV 93
 
Name Accession Description Interval E-value
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
74-123 9.54e-05

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 41.81  E-value: 9.54e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 404351626  74 GRPGKTV-DLGSGDGRIVLAAHRCGLRPAVGYELNPWLVALARLHAWRAGC 123
Cdd:COG2263   43 DIEGKTVlDLGCGTGMLAIGAALLGAKKVVGVDIDPEALEIARENAERLGV 93
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 66-139 1.22e-04

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 40.75  E-value: 1.22e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 404351626  66 EHVLSLLRGRPGKTV-DLGSGDGRIVLAAHRCGLRpAVGYELNPWLVALARLHAWRAGCagSVCYRRKDLWKLPL 139
Cdd:COG2226   12 EALLAALGLRPGARVlDLGCGTGRLALALAERGAR-VTGVDISPEMLELARERAAEAGL--NVEFVVGDAEDLPF 83
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 63-143 6.46e-04

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 38.46  E-value: 6.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 404351626  63 RQVEHVLSLLRGRPGKTVDLGSGDGRIVLAAHRCGLRpAVGYELNPWLVALARLHAWRAGcagsVCYRRKDLWKLPLLED 142
Cdd:COG2227   12 RRLAALLARLLPAGGRVLDVGCGTGRLALALARRGAD-VTGVDISPEALEIARERAAELN----VDFVQGDLEDLPLEDG 86


                 .
gi 404351626 143 K 143
Cdd:COG2227   87 S 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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