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Conserved domains on  [gi|405113037|ref|NP_001258275|]
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DNA damage-binding protein 2 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 115-419 1.84e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 1.84e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 115 TSLAWHPtHPSTLAVGSKGGDIMIWNFGIKDKPIFLKGigAGGSITGLKFnHLNTNQFFASSMEGTTRLQDF-KGNILRI 193
Cdd:cd00200   13 TCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKG--HTGPVRDVAA-SADGTYLASGSSDKTIRLWDLeTGECVRT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 194 YTSSNSckvWFCSLDVSAKSRVVVTGDNMGHVILTNTD-GKELWNLRMHKKKVAHVALNPCcDWLLATASIDQTVKIWDL 272
Cdd:cd00200   89 LTGHTS---YVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 273 RQIKGKDSFLFslpHRHPVNSACFSPDGARLLTTDQNNEIRVYSASQWDSPLSLISHPHrhfqhltPIKATWHSRHNLIV 352
Cdd:cd00200  165 RTGKCVATLTG---HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN-------GVNSVAFSPDGYLL 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405113037 353 VGRYPDpnlkscvpyelRTIDVFDGSSGKMMCQLydPGYSG-ITSLnEFNPMGDTLAStmGYH---ILIWS 419
Cdd:cd00200  235 ASGSED-----------GTIRVWDLRTGECVQTL--SGHTNsVTSL-AWSPDGKRLAS--GSAdgtIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 115-419 1.84e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 1.84e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 115 TSLAWHPtHPSTLAVGSKGGDIMIWNFGIKDKPIFLKGigAGGSITGLKFnHLNTNQFFASSMEGTTRLQDF-KGNILRI 193
Cdd:cd00200   13 TCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKG--HTGPVRDVAA-SADGTYLASGSSDKTIRLWDLeTGECVRT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 194 YTSSNSckvWFCSLDVSAKSRVVVTGDNMGHVILTNTD-GKELWNLRMHKKKVAHVALNPCcDWLLATASIDQTVKIWDL 272
Cdd:cd00200   89 LTGHTS---YVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 273 RQIKGKDSFLFslpHRHPVNSACFSPDGARLLTTDQNNEIRVYSASQWDSPLSLISHPHrhfqhltPIKATWHSRHNLIV 352
Cdd:cd00200  165 RTGKCVATLTG---HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN-------GVNSVAFSPDGYLL 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405113037 353 VGRYPDpnlkscvpyelRTIDVFDGSSGKMMCQLydPGYSG-ITSLnEFNPMGDTLAStmGYH---ILIWS 419
Cdd:cd00200  235 ASGSED-----------GTIRVWDLRTGECVQTL--SGHTNsVTSL-AWSPDGKRLAS--GSAdgtIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
115-318 3.53e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 3.53e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 115 TSLAWHPTHpSTLAVGSKGGDIMIWNfgIKDKPIFLKGIGAGGSITGLKFNHlnTNQFFAS-SMEGTTRLQDFK-GNILR 192
Cdd:COG2319  208 RSVAFSPDG-KLLASGSADGTVRLWD--LATGKLLRTLTGHSGSVRSVAFSP--DGRLLASgSADGTVRLWDLAtGELLR 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 193 IYTSSNSckvWFCSLDVSAKSRVVVTGDNMGHVILTNTD-GKELWNLRMHKKKVAHVALNPCCDWLlATASIDQTVKIWD 271
Cdd:COG2319  283 TLTGHSG---GVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWD 358

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 405113037 272 LRQIKGKDSFLfslPHRHPVNSACFSPDGARLLTTDQNNEIRVYSAS 318
Cdd:COG2319  359 LATGELLRTLT---GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 231-271 2.38e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.38e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 405113037   231 DGKELWNLRMHKKKVAHVALNPCCDWLlATASIDQTVKIWD 271
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYL-ASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
232-271 3.79e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.79e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 405113037  232 GKELWNLRMHKKKVAHVALNPCCDWLlATASIDQTVKIWD 271
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLL-ASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 147-352 1.96e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 40.26  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 147 PIFLkgiGAGGSITGLKFNHLNTNQFFASSMEGTTrlqdFKGNILRIYTSSNsckvwfcsldvsaksrvvvTGDNMGHvi 226
Cdd:PTZ00421  69 PILL---GQEGPIIDVAFNPFDPQKLFTASEDGTI----MGWGIPEEGLTQN-------------------ISDPIVH-- 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 227 ltntdgkelwnLRMHKKKVAHVALNPCCDWLLATASIDQTVKIWDLRQIKGKDSFlfsLPHRHPVNSACFSPDGARLLTT 306
Cdd:PTZ00421 121 -----------LQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVI---KCHSDQITSLEWNLDGSLLCTT 186

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 405113037 307 DQNNEIRVYSASQWDSPLSLISHPHRHFQhltpiKATWHSRHNLIV 352
Cdd:PTZ00421 187 SKDKKLNIIDPRDGTIVSSVEAHASAKSQ-----RCLWAKRKDLII 227
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 115-419 1.84e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.28  E-value: 1.84e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 115 TSLAWHPtHPSTLAVGSKGGDIMIWNFGIKDKPIFLKGigAGGSITGLKFnHLNTNQFFASSMEGTTRLQDF-KGNILRI 193
Cdd:cd00200   13 TCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKG--HTGPVRDVAA-SADGTYLASGSSDKTIRLWDLeTGECVRT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 194 YTSSNSckvWFCSLDVSAKSRVVVTGDNMGHVILTNTD-GKELWNLRMHKKKVAHVALNPCcDWLLATASIDQTVKIWDL 272
Cdd:cd00200   89 LTGHTS---YVSSVAFSPDGRILSSSSRDKTIKVWDVEtGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 273 RQIKGKDSFLFslpHRHPVNSACFSPDGARLLTTDQNNEIRVYSASQWDSPLSLISHPHrhfqhltPIKATWHSRHNLIV 352
Cdd:cd00200  165 RTGKCVATLTG---HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN-------GVNSVAFSPDGYLL 234

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 405113037 353 VGRYPDpnlkscvpyelRTIDVFDGSSGKMMCQLydPGYSG-ITSLnEFNPMGDTLAStmGYH---ILIWS 419
Cdd:cd00200  235 ASGSED-----------GTIRVWDLRTGECVQTL--SGHTNsVTSL-AWSPDGKRLAS--GSAdgtIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
115-318 3.53e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 3.53e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 115 TSLAWHPTHpSTLAVGSKGGDIMIWNfgIKDKPIFLKGIGAGGSITGLKFNHlnTNQFFAS-SMEGTTRLQDFK-GNILR 192
Cdd:COG2319  208 RSVAFSPDG-KLLASGSADGTVRLWD--LATGKLLRTLTGHSGSVRSVAFSP--DGRLLASgSADGTVRLWDLAtGELLR 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 193 IYTSSNSckvWFCSLDVSAKSRVVVTGDNMGHVILTNTD-GKELWNLRMHKKKVAHVALNPCCDWLlATASIDQTVKIWD 271
Cdd:COG2319  283 TLTGHSG---GVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWD 358

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 405113037 272 LRQIKGKDSFLfslPHRHPVNSACFSPDGARLLTTDQNNEIRVYSAS 318
Cdd:COG2319  359 LATGELLRTLT---GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
115-409 4.36e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.59  E-value: 4.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 115 TSLAWHPTHpSTLAVGSKGGDIMIWNfgIKDKPIFLKGIGAGGSITGLKFNHlnTNQFFAS-SMEGTTRLQDFK-GNILR 192
Cdd:COG2319  124 RSVAFSPDG-KTLASGSADGTVRLWD--LATGKLLRTLTGHSGAVTSVAFSP--DGKLLASgSDDGTVRLWDLAtGKLLR 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 193 IYTSSNSckvWFCSLDVSAKSRVVVTGDNMGHVILTNTD-GKELWNLRMHKKKVAHVALNPCCDWLlATASIDQTVKIWD 271
Cdd:COG2319  199 TLTGHTG---AVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSPDGRLL-ASGSADGTVRLWD 274

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 272 LRQikGKDSFLFSlPHRHPVNSACFSPDGARLLTTDQNNEIRVYSASQWDSPLSLISHPHRHFQhltpikATWHSRHNLI 351
Cdd:COG2319  275 LAT--GELLRTLT-GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS------VAFSPDGKTL 345

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 405113037 352 VVGRYpDpnlkscvpyelRTIDVFDGSSGKMMCQLYDPGySGITSLnEFNPMGDTLAS 409
Cdd:COG2319  346 ASGSD-D-----------GTVRLWDLATGELLRTLTGHT-GAVTSV-AFSPDGRTLAS 389
WD40 COG2319
WD40 repeat [General function prediction only];
203-421 4.47e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.57  E-value: 4.47e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 203 WFCSLDVSAKSRVVVTGDNMGHVILTNTD-GKELWNLRMHKKKVAHVALNPCCDWLlATASIDQTVKIWDLRQIKgkdsF 281
Cdd:COG2319   80 AVLSVAFSPDGRLLASASADGTVRLWDLAtGLLLRTLTGHTGAVRSVAFSPDGKTL-ASGSADGTVRLWDLATGK----L 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 282 LFSLP-HRHPVNSACFSPDGARLLTTDQNNEIRVYSASQWDSPLSLISHPHRHFQhltpikATWHSRHNLIVVGRYPdpn 360
Cdd:COG2319  155 LRTLTgHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS------VAFSPDGKLLASGSAD--- 225

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 405113037 361 lkscvpyelRTIDVFDGSSGKMMCQLYDPGySGITSLnEFNPMGDTLASTMGYH-ILIWSPE 421
Cdd:COG2319  226 ---------GTVRLWDLATGKLLRTLTGHS-GSVRSV-AFSPDGRLLASGSADGtVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
206-332 6.19e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 6.19e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 206 SLDVSAKSRVVVTGDNMGHVILTNTDGKELWNLRMHKKKVAHVALNPCcDWLLATASIDQTVKIWDLrqiKGKDSFLFSL 285
Cdd:COG2319   42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPD-GRLLASASADGTVRLWDL---ATGLLLRTLT 117

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 405113037 286 PHRHPVNSACFSPDGARLLTTDQNNEIRVYSASQWDSPLSLISHPHR 332
Cdd:COG2319  118 GHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGA 164
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 238-331 1.36e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.64  E-value: 1.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 238 LRMHKKKVAHVALNPCCDWlLATASIDQTVKIWDLRqikgKDSFLFSLP-HRHPVNSACFSPDGARLLTTDQNNEIRVYS 316
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLE----TGELLRTLKgHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90
                 ....*....|....*
gi 405113037 317 ASQWDSPLSLISHPH 331
Cdd:cd00200   80 LETGECVRTLTGHTS 94
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 231-271 2.38e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.38e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 405113037   231 DGKELWNLRMHKKKVAHVALNPCCDWLlATASIDQTVKIWD 271
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYL-ASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
232-271 3.79e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 3.79e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 405113037  232 GKELWNLRMHKKKVAHVALNPCCDWLlATASIDQTVKIWD 271
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLL-ASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 147-352 1.96e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 40.26  E-value: 1.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 147 PIFLkgiGAGGSITGLKFNHLNTNQFFASSMEGTTrlqdFKGNILRIYTSSNsckvwfcsldvsaksrvvvTGDNMGHvi 226
Cdd:PTZ00421  69 PILL---GQEGPIIDVAFNPFDPQKLFTASEDGTI----MGWGIPEEGLTQN-------------------ISDPIVH-- 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 405113037 227 ltntdgkelwnLRMHKKKVAHVALNPCCDWLLATASIDQTVKIWDLRQIKGKDSFlfsLPHRHPVNSACFSPDGARLLTT 306
Cdd:PTZ00421 121 -----------LQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVI---KCHSDQITSLEWNLDGSLLCTT 186

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 405113037 307 DQNNEIRVYSASQWDSPLSLISHPHRHFQhltpiKATWHSRHNLIV 352
Cdd:PTZ00421 187 SKDKKLNIIDPRDGTIVSSVEAHASAKSQ-----RCLWAKRKDLII 227
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 287-316 2.90e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.90e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 405113037   287 HRHPVNSACFSPDGARLLTTDQNNEIRVYS 316
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 287-354 5.92e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 38.47  E-value: 5.92e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 405113037 287 HRHPVNSACFSPDGARLLTTDQNNEIRVYSASQWDSPLSLISHPHrhfqhltPIKA-TWHSRHNLIVVG 354
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG-------PVRDvAASADGTYLASG 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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