NCBI Conserved Domain Search

NCBI

3D Macromolecular Structures

Conserved Domains

Conserved domains on [gi|436408719|ref|NP_001258966|]

View

thrombospondin-type laminin G domain and EAR repeat-containing protein isoform 2 [Homo sapiens]

Protein Classification

LamG domain-containing protein( domain architecture ID 10430276)

LamG (Laminin G) domain-containing protein may serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules; similar to Oncorhynchus mykiss sex hormone-binding globulin beta form that may participate in the local control of ovarian functions in salmonids

Graphical summary

Zoom to residue level

show extra options »

Show site features Horizontal zoom: ×

List of domain hits

Name

Accession

Description

Interval

E-value

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

292-338

2.81e-14

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

:

Pssm-ID: 461033 Cd Length: 41 Bit Score: 66.72 E-value: 2.81e-14

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 436408719  292 KFVSYQNIPTHQAQAWRHFTIGKKIFLAVANFepdekgQEFSVIYKW 338
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANF------SGDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

344-390

3.49e-14

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

:

Pssm-ID: 461033 Cd Length: 41 Bit Score: 66.72 E-value: 3.49e-14

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 436408719  344 KFTPYQSIATHSARDWEAFEVDGEHFLAVAnhregdNHNIDSVIYKW 390
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVA------NFSGDSVIYRW 41

LamG super family

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...

14-154

1.33e-11

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.

The actual alignment was detected with superfamily member smart00210:

Pssm-ID: 473984 Cd Length: 184 Bit Score: 63.53 E-value: 1.33e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 436408719    14 LFPEEFSIVVTLRvpnLPPKRNEYLLTVVaEESDLLLLGLRLSPAQLHFLFLREDTAGAWQTrVSFRSPALVDGRWHTLV 93
Cdd:smart00210  49 GLPEDFSLLTTFR---QTPKSRGVLFAIY-DAQNVRQFGLEVDGRANTLLLRYQGVDGKQHT-VSFRNLPLADGQWHKLA 123

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 436408719    94 LAVSAGVFSLTTDCGLPVDIMADVPFPATLSVKGARFFVGsRRRAKGLFMGLVRQLVLLPG 154
Cdd:smart00210 124 LSVSGSSATLYVDCNEIDSRPLDRPGQPPIDTDGIEVRGA-QAADRKPFQGDLQQLKIVCD 183

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

507-552

1.84e-11

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

:

Pssm-ID: 461033 Cd Length: 41 Bit Score: 59.02 E-value: 1.84e-11

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 436408719  507 FVKFQDILTCSALDWEFFSVGEDYFLVVANsfdgrtFSVNSIIYRW 552
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVAN------FSGDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

397-433

6.75e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

:

Pssm-ID: 461033 Cd Length: 41 Bit Score: 45.92 E-value: 6.75e-07

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 436408719  397 FEANQTIATSGAYDWEFFSVGPYSFLVVANtFNGTST 433
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVAN-FSGDSV 37

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

447-499

8.89e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

:

Pssm-ID: 461033 Cd Length: 41 Bit Score: 45.54 E-value: 8.89e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 436408719  447 FQLFQSFPTFGAADWEVFQIGERIFLAVANshsydvemqvqndsYVINSVIYE 499
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVAN--------------FSGDSVIYR 40

Name

Accession

Description

Interval

E-value

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

292-338

2.81e-14

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 66.72 E-value: 2.81e-14

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 436408719  292 KFVSYQNIPTHQAQAWRHFTIGKKIFLAVANFepdekgQEFSVIYKW 338
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANF------SGDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

344-390

3.49e-14

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 66.72 E-value: 3.49e-14

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 436408719  344 KFTPYQSIATHSARDWEAFEVDGEHFLAVAnhregdNHNIDSVIYKW 390
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVA------NFSGDSVIYRW 41

TSPN

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...

14-154

1.33e-11

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin

Pssm-ID: 214560 Cd Length: 184 Bit Score: 63.53 E-value: 1.33e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 436408719    14 LFPEEFSIVVTLRvpnLPPKRNEYLLTVVaEESDLLLLGLRLSPAQLHFLFLREDTAGAWQTrVSFRSPALVDGRWHTLV 93
Cdd:smart00210  49 GLPEDFSLLTTFR---QTPKSRGVLFAIY-DAQNVRQFGLEVDGRANTLLLRYQGVDGKQHT-VSFRNLPLADGQWHKLA 123

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 436408719    94 LAVSAGVFSLTTDCGLPVDIMADVPFPATLSVKGARFFVGsRRRAKGLFMGLVRQLVLLPG 154
Cdd:smart00210 124 LSVSGSSATLYVDCNEIDSRPLDRPGQPPIDTDGIEVRGA-QAADRKPFQGDLQQLKIVCD 183

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

507-552

1.84e-11

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 59.02 E-value: 1.84e-11

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 436408719  507 FVKFQDILTCSALDWEFFSVGEDYFLVVANsfdgrtFSVNSIIYRW 552
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVAN------FSGDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

397-433

6.75e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 45.92 E-value: 6.75e-07

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 436408719  397 FEANQTIATSGAYDWEFFSVGPYSFLVVANtFNGTST 433
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVAN-FSGDSV 37

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

447-499

8.89e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 45.54 E-value: 8.89e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 436408719  447 FQLFQSFPTFGAADWEVFQIGERIFLAVANshsydvemqvqndsYVINSVIYE 499
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVAN--------------FSGDSVIYR 40

Name

Accession

Description

Interval

E-value

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

292-338

2.81e-14

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 66.72 E-value: 2.81e-14

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 436408719  292 KFVSYQNIPTHQAQAWRHFTIGKKIFLAVANFepdekgQEFSVIYKW 338
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANF------SGDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

344-390

3.49e-14

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 66.72 E-value: 3.49e-14

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 436408719  344 KFTPYQSIATHSARDWEAFEVDGEHFLAVAnhregdNHNIDSVIYKW 390
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVA------NFSGDSVIYRW 41

TSPN

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of ...

14-154

1.33e-11

Thrombospondin N-terminal -like domains; Heparin-binding and cell adhesion domain of thrombospondin

Pssm-ID: 214560 Cd Length: 184 Bit Score: 63.53 E-value: 1.33e-11

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 436408719    14 LFPEEFSIVVTLRvpnLPPKRNEYLLTVVaEESDLLLLGLRLSPAQLHFLFLREDTAGAWQTrVSFRSPALVDGRWHTLV 93
Cdd:smart00210  49 GLPEDFSLLTTFR---QTPKSRGVLFAIY-DAQNVRQFGLEVDGRANTLLLRYQGVDGKQHT-VSFRNLPLADGQWHKLA 123

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 436408719    94 LAVSAGVFSLTTDCGLPVDIMADVPFPATLSVKGARFFVGsRRRAKGLFMGLVRQLVLLPG 154
Cdd:smart00210 124 LSVSGSSATLYVDCNEIDSRPLDRPGQPPIDTDGIEVRGA-QAADRKPFQGDLQQLKIVCD 183

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

507-552

1.84e-11

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 59.02 E-value: 1.84e-11

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 436408719  507 FVKFQDILTCSALDWEFFSVGEDYFLVVANsfdgrtFSVNSIIYRW 552
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVAN------FSGDSVIYRW 41

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

397-433

6.75e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 45.92 E-value: 6.75e-07

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 436408719  397 FEANQTIATSGAYDWEFFSVGPYSFLVVANtFNGTST 433
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVAN-FSGDSV 37

EPTP

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...

447-499

8.89e-07

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.

Pssm-ID: 461033 Cd Length: 41 Bit Score: 45.54 E-value: 8.89e-07

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 436408719  447 FQLFQSFPTFGAADWEVFQIGERIFLAVANshsydvemqvqndsYVINSVIYE 499
Cdd:pfam03736   2 FVPYQTIPTRGARDVEPFSIGGDLFLAVAN--------------FSGDSVIYR 40

LamG

Laminin G domain;

71-151

1.93e-03

Laminin G domain;

Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 38.86 E-value: 1.93e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 436408719    71 GAWQTRVSFRSPALVDGRWHTLVLAVSAGVFSLTTDCGLPVDIMADvPFPATLSVKGaRFFVG----SRRRAKGL----F 142
Cdd:smart00282  43 GSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGGNRVSGESP-GGLTILNLDG-PLYLGglpeDLKLPPLPvtpgF 120


                   ....*....
gi 436408719   143 MGLVRQLVL 151
Cdd:smart00282 121 RGCIRNLKV 129

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01

References:

Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.

Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH

of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

Functional characterization of the conserved domain architecture found on the query. Click here to see more details.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

The CD-Search help document provides more detail about the tool and its features.

Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

Modify your query to search against a different database and/or use advanced search options