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Conserved domains on  [gi|440309859|ref|NP_001258979|]
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thymidine kinase 2, mitochondrial isoform 7 precursor [Homo sapiens]

Protein Classification

nucleoside/nucleotide kinase family protein( domain architecture ID 106737)

nucleoside/nucleotide kinase family protein may catalyze the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NK super family cl17190
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 1-163 4.97e-60

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


The actual alignment was detected with superfamily member pfam01712:

Pssm-ID: 450170  Cd Length: 201  Bit Score: 184.83  E-value: 4.97e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440309859    1 MYHDASRWGLTLQTYVQLTMLDRHTRP-QVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDvSV 79
Cdd:pfam01712  42 FYKDPSRWSFALQTYFLNSRFKQQLEAfFTGQVVILERSIYSDRYIFAKMLYDKGTMSDEEYKTYKDLYDNMLLEFP-KP 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440309859   80 DLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFpmaaPVLVIEADhhmERMLELFEQNRDRIL 159
Cdd:pfam01712 121 DLIIYLKTSPETCLERIKKRGRTEEQNISLDYLERLHEKYEAWLKKLNLS----PVLVIDGD---ELDFVFFEEDREDVM 193


                  ....
gi 440309859  160 TPEN 163
Cdd:pfam01712 194 NEVN 197
 
Name Accession Description Interval E-value
dNK pfam01712
Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2. ...
 1-163 4.97e-60

Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyze the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.


Pssm-ID: 396326  Cd Length: 201  Bit Score: 184.83  E-value: 4.97e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440309859    1 MYHDASRWGLTLQTYVQLTMLDRHTRP-QVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDvSV 79
Cdd:pfam01712  42 FYKDPSRWSFALQTYFLNSRFKQQLEAfFTGQVVILERSIYSDRYIFAKMLYDKGTMSDEEYKTYKDLYDNMLLEFP-KP 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440309859   80 DLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFpmaaPVLVIEADhhmERMLELFEQNRDRIL 159
Cdd:pfam01712 121 DLIIYLKTSPETCLERIKKRGRTEEQNISLDYLERLHEKYEAWLKKLNLS----PVLVIDGD---ELDFVFFEEDREDVM 193


                  ....
gi 440309859  160 TPEN 163
Cdd:pfam01712 194 NEVN 197
dNK cd01673
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to ...
 1-142 1.02e-46

Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.


Pssm-ID: 238836  Cd Length: 193  Bit Score: 150.84  E-value: 1.02e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440309859   1 MYHDASRWGLTLQTYVQLTMLDRHTRPQVSS----VRLMERSIHSARYIFVENLYRSGKMPeVDYVVLSEWFDWILRNmD 76
Cdd:cd01673   45 FYEDPKRWAFPFQLYFLLSRLKQYKDALEHLstgqGVILERSIFSDRVFAEANLKEGGIMK-TEYDLYNELFDNLIPE-L 122

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 440309859  77 VSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKgsLFPMAAPVLVIEADH 142
Cdd:cd01673  123 LPPDLVIYLDASPETCLKRIKKRGRPEEQGIPLDYLEDLHEAYEKWFLP--QMYEKAPVLIIDANE 186
Dck COG1428
Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];
2-142 3.13e-26

Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];


Pssm-ID: 441037 [Multi-domain]  Cd Length: 205  Bit Score: 98.71  E-value: 3.13e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440309859   2 YHDASRWGLTLQTY------VQLTMLDRHTRPQVSsvrlmERSIHSARyIFVENLYRSGKMPEVDYVVLSEWFDWILRNM 75
Cdd:COG1428   46 YEDPKRWAFPLQLFfllsrfKQLKDLRQFGGNVVS-----DRSIYKDA-IFAKLLHEMGTLSDREFDLYRQLFDNLTEDL 119

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 440309859  76 dVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKgslFPmAAPVLVIEADH 142
Cdd:COG1428  120 -PKPDLVIYLQASVDTLLERIKKRGRDYEQNIDLDYLERLNEAYEEWFEH---YD-ASPVLIIDTDE 181
PHA03132 PHA03132
thymidine kinase; Provisional
 80-116 1.09e-03

thymidine kinase; Provisional


Pssm-ID: 222997 [Multi-domain]  Cd Length: 580  Bit Score: 38.59  E-value: 1.09e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 440309859  80 DLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIH 116
Cdd:PHA03132 403 DVIVLLKLNSEENLRRVKKRGRKEEKGINLTYLKELN 439
 
Name Accession Description Interval E-value
dNK pfam01712
Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2. ...
 1-163 4.97e-60

Deoxynucleoside kinase; This family consists of various deoxynucleoside kinases cytidine EC:2.7.1.74, guanosine EC:2.7.1.113, adenosine EC:2.7.1.76 and thymidine kinase EC:2.7.1.21 (which also phosphorylates deoxyuridine and deoxycytosine.) These enzymes catalyze the production of deoxynucleotide 5'-monophosphate from a deoxynucleoside. Using ATP and yielding ADP in the process.


Pssm-ID: 396326  Cd Length: 201  Bit Score: 184.83  E-value: 4.97e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440309859    1 MYHDASRWGLTLQTYVQLTMLDRHTRP-QVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDvSV 79
Cdd:pfam01712  42 FYKDPSRWSFALQTYFLNSRFKQQLEAfFTGQVVILERSIYSDRYIFAKMLYDKGTMSDEEYKTYKDLYDNMLLEFP-KP 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440309859   80 DLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFpmaaPVLVIEADhhmERMLELFEQNRDRIL 159
Cdd:pfam01712 121 DLIIYLKTSPETCLERIKKRGRTEEQNISLDYLERLHEKYEAWLKKLNLS----PVLVIDGD---ELDFVFFEEDREDVM 193


                  ....
gi 440309859  160 TPEN 163
Cdd:pfam01712 194 NEVN 197
dNK cd01673
Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to ...
 1-142 1.02e-46

Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1.113), adenosine (EC 2.7.1.76), and thymidine (EC 2.7.1.21) kinases. They are key enzymes in the salvage of deoxyribonucleosides originating from extra- or intracellular breakdown of DNA.


Pssm-ID: 238836  Cd Length: 193  Bit Score: 150.84  E-value: 1.02e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440309859   1 MYHDASRWGLTLQTYVQLTMLDRHTRPQVSS----VRLMERSIHSARYIFVENLYRSGKMPeVDYVVLSEWFDWILRNmD 76
Cdd:cd01673   45 FYEDPKRWAFPFQLYFLLSRLKQYKDALEHLstgqGVILERSIFSDRVFAEANLKEGGIMK-TEYDLYNELFDNLIPE-L 122

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 440309859  77 VSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKgsLFPMAAPVLVIEADH 142
Cdd:cd01673  123 LPPDLVIYLDASPETCLKRIKKRGRPEEQGIPLDYLEDLHEAYEKWFLP--QMYEKAPVLIIDANE 186
Dck COG1428
Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];
2-142 3.13e-26

Deoxyadenosine/deoxycytidine kinase [Nucleotide transport and metabolism];


Pssm-ID: 441037 [Multi-domain]  Cd Length: 205  Bit Score: 98.71  E-value: 3.13e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440309859   2 YHDASRWGLTLQTY------VQLTMLDRHTRPQVSsvrlmERSIHSARyIFVENLYRSGKMPEVDYVVLSEWFDWILRNM 75
Cdd:COG1428   46 YEDPKRWAFPLQLFfllsrfKQLKDLRQFGGNVVS-----DRSIYKDA-IFAKLLHEMGTLSDREFDLYRQLFDNLTEDL 119

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 440309859  76 dVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKgslFPmAAPVLVIEADH 142
Cdd:COG1428  120 -PKPDLVIYLQASVDTLLERIKKRGRDYEQNIDLDYLERLNEAYEEWFEH---YD-ASPVLIIDTDE 181
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
77-114 3.10e-04

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 39.41  E-value: 3.10e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 440309859  77 VSVDLIVYLRTNPETCYQRLKKRCREEEKVipLEYLEA 114
Cdd:COG1936   80 VDVDRVIVLRCNPEVLEERLEERGYSEEKI--RENVEA 115
NDUO42 cd02030
NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar ...
 35-130 3.34e-04

NADH:Ubiquinone oxioreductase, 42 kDa (NDUO42) is a family of proteins that are highly similar to deoxyribonucleoside kinases (dNK). Members of this family have been identified as one of the subunits of NADH:Ubiquinone oxioreductase (complex I), a multi-protein complex located in the inner mitochondrial membrane. The main function of the complex is to transport electrons from NADH to ubiquinone, which is accompanied by the translocation of protons from the mitochondrial matrix to the inter membrane space.


Pssm-ID: 238988  Cd Length: 219  Bit Score: 39.65  E-value: 3.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 440309859  35 MERSIHSaRYIFVENLYRSGKMP--------EVDYVVLSEWFdwilrnmdvSVDLIVYLRTNPETCYQRLKKRCREEEKV 106
Cdd:cd02030  101 LERSPFS-DFVFLEAMYKQGYIRkqcvdhynEVKGNTIPELL---------PPHLVIYLDVPVPEVQKRIKKRGDPHEMK 170

                         90       100
                 ....*....|....*....|....
gi 440309859 107 IPLEYLEAIhhlheEWLIKGSLFP 130
Cdd:cd02030  171 VTSAYLQDI-----ENAYKKTFLP 189
PHA03132 PHA03132
thymidine kinase; Provisional
 80-116 1.09e-03

thymidine kinase; Provisional


Pssm-ID: 222997 [Multi-domain]  Cd Length: 580  Bit Score: 38.59  E-value: 1.09e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 440309859  80 DLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIH 116
Cdd:PHA03132 403 DVIVLLKLNSEENLRRVKKRGRKEEKGINLTYLKELN 439
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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