BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452 102 FVDVTLACDERSFTAHKVVLSACSPYFRRLLKA-NPCEHPIVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHL 180
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 442627452 181 LQIRG 185
Cdd:cd18315   81 LQIKG 85

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452 102 FVDVTLACDERSFTAHKVVLSACSPYFRRLLKA-NPCEHPIVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHL 180
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 442627452 181 LQIRG 185
Cdd:cd18315   81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452   104 DVTLACDERSFTAHKVVLSACSPYFRRLLKANPCE--HPIVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLL 181
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKEsdKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*...
gi 442627452   182 QIRGLADV 189
Cdd:smart00225  81 QIPGLVEL 88

kelch-like protein; Provisional

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442627452 115 TAHKVVLSACSPYFRRLLKANPCEHPIVILRDVrcDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLLQI 183
Cdd:PHA03098  24 KVHKIILSSSSEYFKKMFKNNFKENEINLNIDY--DSFNEVIKYIYTGKINITSNNVKDILSIANYLII 90

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452 102 FVDVTLACDERSFTAHKVVLSACSPYFRRLLKA-NPCEHPIVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHL 180
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80

                 ....*
gi 442627452 181 LQIRG 185
Cdd:cd18315   81 LQIKG 85

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452   104 DVTLACDERSFTAHKVVLSACSPYFRRLLKANPCE--HPIVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLL 181
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKEsdKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                   ....*...
gi 442627452   182 QIRGLADV 189
Cdd:smart00225  81 QIPGLVEL 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  90 LSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCE--HPIVILRDVRCDDVENLLSFMYNGEVNVS 167
Cdd:cd18238    3 FKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAEskQDSITIKDIDEEAVELLVDFAYTGKLTLT 82

                         90       100
                 ....*....|....*....|..
gi 442627452 168 HEQLPDFLKTAHLLQIRGLADV 189
Cdd:cd18238   83 VDNVQSLLYAASLLQVEEVAKA 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  87 SSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCE--HPIVILRDVRCDDVENLLSFMYNGEV 164
Cdd:cd18256    5 SLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSEssKDVVQIHGVEPDIFHILLDFIYTGVV 84

                         90
                 ....*....|....*....
gi 442627452 165 NVSHEQLPDFLKTAHLLQI 183
Cdd:cd18256   85 EVTVSNVQELLVAADMLQL 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  84 DFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHPI--VILRDVRCDDVENLLSFMYN 161
Cdd:cd18247    1 DLPSSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQdeITMQGIEPSALEALINFAYS 80

                         90       100
                 ....*....|....*....|..
gi 442627452 162 GEVNVSHEQLPDFLKTAHLLQI 183
Cdd:cd18247   81 GRIAIDTSNVQSLLVGASFLQL 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  89 ILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHPIVILrDVRCDD---VENLLSFMYNGEVN 165
Cdd:cd18257    5 LLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEV-EFQCIDetaLQAIVEYAYTGTVF 83

                         90
                 ....*....|....*....
gi 442627452 166 VSHEQLPDFLKTAHLLQIR 184
Cdd:cd18257   84 ISQATVESLLPAANLLQIK 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  88 SILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHpIVILRDVRCDDVENLLSFMYNGEVNVS 167
Cdd:cd18260    4 NLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLQ-RVELNDISPLGLATVITYAYTGKLTLS 82

                         90
                 ....*....|....*....
gi 442627452 168 HEQLPDFLKTAHLLQIRGL 186
Cdd:cd18260   83 LYTIGSTISAASYLQIHAL 101

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452 100 EDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHPI--VILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKT 177
Cdd:cd18314    4 SEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLkeVTLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLML 83

                         90
                 ....*....|
gi 442627452 178 AHLLQIRGLA 187
Cdd:cd18314   84 ASKYQVPDLE 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452 102 FVDVTLACDERSFTAHKVVLSACSPYFRRLLKANP---CEHPIVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTA 178
Cdd:cd18293   15 FCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPppaGQKVVLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLAAA 94

                 ....*...
gi 442627452 179 HLLQIRGL 186
Cdd:cd18293   95 RRLQISEL 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  90 LSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKA--NPCEHPIVILRDVRCDDVENLLSFMYNGEVNVS 167
Cdd:cd18240    5 CNVFNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNgwNETEKKVYKIPGVSPEMMELIIEYAYTRTVPIT 84

                         90
                 ....*....|....*....
gi 442627452 168 HEQLPDFLKTAHLLQIRGL 186
Cdd:cd18240   85 AENVEELLPAADQFNIMGI 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  84 DFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPC--EHPIVILRDVRCDDVENLLSFMYN 161
Cdd:cd18326    7 DHSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGAVvdQQNVYEIDFVSAEALTALLDFAYT 86

                         90       100
                 ....*....|....*....|....*...
gi 442627452 162 GEVNVSHEQLPDFLKTAHLLQIRGLADV 189
Cdd:cd18326   87 ATLTVSTSNVGDILSAARLLEIPAVSHV 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  84 DFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANpcEHPIVILRDVRCDDV-ENLLSFMYNG 162
Cdd:cd18222    7 DFSNSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLN--EMSTVSISVIKNPTVfEQLLSFCYTG 84

                         90       100
                 ....*....|....*....|....*.
gi 442627452 163 EVNVSHEQLPDFLKTAHLLQIRGLAD 188
Cdd:cd18222   85 RICLQLADIISYLTAASFLQMQHIID 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  90 LSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHPI--VILRDVRCDDVENLLSFMYNGEVNVS 167
Cdd:cd18235    9 FDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRAnrVTLQDVDGKALLLLIDYVYTAEIQVT 88

                         90       100
                 ....*....|....*....|..
gi 442627452 168 HEQLPDFLKTAHLLQirgLADV 189
Cdd:cd18235   89 EENVQVLLPAANLLQ---LTDV 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  95 HLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCE--HPIVILRDVRCDDVENLLSFMYNGEV---NVSHE 169
Cdd:cd18297    5 HYVNNPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEaqTPVIEIPDIRYDIFQLMMQYLYTGGVeslDVAQD 84

                         90
                 ....*....|....*..
gi 442627452 170 QLPDFLKTAHLLQIRGL 186
Cdd:cd18297   85 DALELLRAASFFQLDGL 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  87 SSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFR---------RLLKANPCEHPIVILRDVRCDDVENLLS 157
Cdd:cd18228    4 QELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRsklvgqaspRLVLVSPAGKCVLDLHHVTVTGFAPLLE 83

                         90       100       110
                 ....*....|....*....|....*....|
gi 442627452 158 FMYNGEVNVSHEQLPDFLKTAHLLQIRGLA 187
Cdd:cd18228   84 YAYTSTLSINTENIIDVLAAASYMQMFNVA 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  88 SILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEH--PIVILRDVRCDDVENLLSFMYNGEVN 165
Cdd:cd18259   18 SILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESisARVEIKDVDPAVMESLIDFAYTGKLT 97

                         90       100
                 ....*....|....*....|....*...
gi 442627452 166 VSHEQLPDFLKTAHLLQIRGLADVNGGY 193
Cdd:cd18259   98 INQGNVEALIRTSNRLQFPTVRKVCSRY 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  89 ILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHP----IVILRDVRCDDVENLLSFMYNGEV 164
Cdd:cd18245    1 LLRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDgstyKIELEGISVEVMEEILDYIYTGQI 80

                         90       100
                 ....*....|....*....|....
gi 442627452 165 NVSHEQLPDFLKTAHLLQIRGLAD 188
Cdd:cd18245   81 KLSEDNIQDIVQAADLLLMTDLKD 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452 102 FVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPCEHPIVILRDVRCD-----DVENLLSFMYNGEVNVSHEQLPDFLK 176
Cdd:cd18307    1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATDELSITIDCDylspeTVEQLLDYFYTGKIVISEKNVEDLLK 80

                         90
                 ....*....|..
gi 442627452 177 TAHLLQIRGLAD 188
Cdd:cd18307   81 GAKYFNIPRLKD 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  81 KWNDFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKanpcehpiVILRDVRCDDVE------- 153
Cdd:cd18266    4 RWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFT--------IGMREAHQKEVElvgasyi 75

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 442627452 154 ---NLLSFMYNGEVNVSHEQLPDFLKTAHLLQIRGLAD 188
Cdd:cd18266   76 glkAVIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVD 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  89 ILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKAN--PCEHPIVILRDVRCDDVENLLSFMYNGEVNV 166
Cdd:cd18265   10 ILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHlkESRQAVVEIQKVSAAAMEVLLDYMYGGGLRI 89

                         90       100
                 ....*....|....*....|..
gi 442627452 167 SHEQLPDFLKTAHLLQIRGLAD 188
Cdd:cd18265   90 QEDNVESVLEASDLLQVSKLRE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  86 QSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKANPC-EHPIVILRDVRCddVENLLSFMYNGEV 164
Cdd:cd18203    9 EAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSsELQVSLMHSSRV--VADLLLSCYTGAL 86

                         90
                 ....*....|....*....
gi 442627452 165 NVSHEQLPDFLKTAHLLQI 183
Cdd:cd18203   87 EFSVRDIVNYLTAASYLQM 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  89 ILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKaNPCEHPIVILRDVRCDDVENLLSFMYNGEVNV-S 167
Cdd:cd18221    5 MLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQ-DFTQEPLVEIEGVSNMAFRHLIEFTYTAKLMVqG 83

                         90
                 ....*....|....*.
gi 442627452 168 HEQLPDFLKTAHLLQI 183
Cdd:cd18221   84 EEEANDVWKAAEYLQM 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  85 FQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLLKAnpcEHPIVILRDVRCDDVENLLSFMYNGE- 163
Cdd:cd18219    4 YSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSV---AGQVVELNFIRADIFAEILNYIYSSKi 80

                         90       100
                 ....*....|....*....|....*.
gi 442627452 164 VNVSHEQLPDFLKTAHLLQIRGLADV 189
Cdd:cd18219   81 VRVRSDLLEELIKSGQLLGVKFIAEL 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452 104 DVTLACDERSFTAHKVVLSACSPYFRRLLKANPCE--HPIVILRDVRCDDVENLLSFMYNGEVNVSHEQLPDFLKTAHLL 181
Cdd:cd18234    3 DVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREatEEEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACLL 82

                 ..
gi 442627452 182 QI 183
Cdd:cd18234   83 QL 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  85 FQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYF--RRLLKANPCEHPIVILRDVrcddVENLLSFMYNG 162
Cdd:cd18229    1 FSKSLLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFhdKLLLGHSEIEVPPVVPAQT----VRQLVEFMYSG 76

                         90       100
                 ....*....|....*....|....*.
gi 442627452 163 EVNVSHEQLPDFLKTAHLLQIRGLAD 188
Cdd:cd18229   77 SLVVAQSEALQILTAASILQIKTVID 102

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627452  84 DFQSSILSSFRHLRDEEDFVDVTLACDERSFTAHKVVLSACSPYFRRLL-------KANPCEhpiviLRDVRCDDVENLL 156
Cdd:cd18198    7 DHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFtsgavvdQQNVYE-----IDFVSPEALTALL 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 442627452 157 SFMYNGEVNVSHEQLPDFLKTAHLLQIRGLADV 189
Cdd:cd18198   82 EFAYTATLTVSTANVGDILSAARLLEIPCVSHV 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.