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Conserved domains on  [gi|442624017|ref|NP_001261047|]
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muscleblind, isoform S [Drosophila melanogaster]

Protein Classification

zinc finger CCCH domain-containing protein( domain architecture ID 10646956)

zinc finger CCCH domain-containing protein similar to Homo sapiens Muscleblind-like proteins

CATH:  4.10.1000.10
Gene Ontology:  GO:0046872|GO:0003676
PubMed:  12665246|27990022
SCOP:  3001741

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnF_C3H1 smart00356
zinc finger;
175-201 3.70e-04

zinc finger;


:

Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 38.38  E-value: 3.70e-04
                           10        20
                   ....*....|....*....|....*..
gi 442624017   175 SDRLEVCREFLRGACKRAESeCRFAHP 201
Cdd:smart00356   1 KYKTELCKFFKRGYCPRGDR-CKFAHP 26
MSCRAMM_ClfA super family cl41352
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 397-522 3.22e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


The actual alignment was detected with superfamily member NF033609:

Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 41.43  E-value: 3.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624017 397 NDSDNDSDRNQDHDKNHDSTADGEADNADRNDAIDQVSNQDNSDQVNLNQNQQNSSPAKDCNTTRTISPNPQDTAATAAT 476
Cdd:NF033609 772 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 851

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 442624017 477 ATETDTLDTESAAAAAAATSATHP--PGDTPPPCQRSPQGDSLLPLPN 522
Cdd:NF033609 852 SDSDSESDSNSDSESGSNNNVVPPnsPKNGTNASNKNEAKDSKEPLPD 899
 
Name Accession Description Interval E-value
ZnF_C3H1 smart00356
zinc finger;
175-201 3.70e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 38.38  E-value: 3.70e-04
                           10        20
                   ....*....|....*....|....*..
gi 442624017   175 SDRLEVCREFLRGACKRAESeCRFAHP 201
Cdd:smart00356   1 KYKTELCKFFKRGYCPRGDR-CKFAHP 26
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 397-522 3.22e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 41.43  E-value: 3.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624017 397 NDSDNDSDRNQDHDKNHDSTADGEADNADRNDAIDQVSNQDNSDQVNLNQNQQNSSPAKDCNTTRTISPNPQDTAATAAT 476
Cdd:NF033609 772 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 851

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 442624017 477 ATETDTLDTESAAAAAAATSATHP--PGDTPPPCQRSPQGDSLLPLPN 522
Cdd:NF033609 852 SDSDSESDSNSDSESGSNNNVVPPnsPKNGTNASNKNEAKDSKEPLPD 899
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
179-202 4.83e-03

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 35.25  E-value: 4.83e-03
                          10        20
                  ....*....|....*....|....*
gi 442624017  179 EVCREFLR-GACKRaESECRFAHPQ 202
Cdd:pfam00642   4 ELCRFFLRtGYCKY-GDRCKFAHGQ 27
 
Name Accession Description Interval E-value
ZnF_C3H1 smart00356
zinc finger;
175-201 3.70e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 38.38  E-value: 3.70e-04
                           10        20
                   ....*....|....*....|....*..
gi 442624017   175 SDRLEVCREFLRGACKRAESeCRFAHP 201
Cdd:smart00356   1 KYKTELCKFFKRGYCPRGDR-CKFAHP 26
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 397-522 3.22e-03

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 41.43  E-value: 3.22e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624017 397 NDSDNDSDRNQDHDKNHDSTADGEADNADRNDAIDQVSNQDNSDQVNLNQNQQNSSPAKDCNTTRTISPNPQDTAATAAT 476
Cdd:NF033609 772 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 851

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 442624017 477 ATETDTLDTESAAAAAAATSATHP--PGDTPPPCQRSPQGDSLLPLPN 522
Cdd:NF033609 852 SDSDSESDSNSDSESGSNNNVVPPnsPKNGTNASNKNEAKDSKEPLPD 899
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
179-202 4.83e-03

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 35.25  E-value: 4.83e-03
                          10        20
                  ....*....|....*....|....*
gi 442624017  179 EVCREFLR-GACKRaESECRFAHPQ 202
Cdd:pfam00642   4 ELCRFFLRtGYCKY-GDRCKFAHGQ 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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