NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|444909133|ref|NP_001263304|]
View 

WD repeat-containing protein 38 isoform 3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
22-288 4.07e-88

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 269.09  E-value: 4.07e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  22 GEMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVS 101
Cdd:COG2319  132 GKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 102 FSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDlrmVTPAVSHQALEGHS 181
Cdd:COG2319  212 FSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD---LATGELLRTLTGHS 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 182 ANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETL 260
Cdd:COG2319  289 GGVNSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL 368

                        250       260
                 ....*....|....*....|....*...
gi 444909133 261 kQGVLDVAHTCAFTPDGKILVSGAADQT 288
Cdd:COG2319  369 -TGHTGAVTSVAFSPDGRTLASGSADGT 395
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
22-288 4.07e-88

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 269.09  E-value: 4.07e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  22 GEMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVS 101
Cdd:COG2319  132 GKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 102 FSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDlrmVTPAVSHQALEGHS 181
Cdd:COG2319  212 FSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD---LATGELLRTLTGHS 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 182 ANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETL 260
Cdd:COG2319  289 GGVNSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL 368

                        250       260
                 ....*....|....*....|....*...
gi 444909133 261 kQGVLDVAHTCAFTPDGKILVSGAADQT 288
Cdd:COG2319  369 -TGHTGAVTSVAFSPDGRTLASGSADGT 395
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-290 3.52e-71

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 221.83  E-value: 3.52e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  11 VRRVKFFGQhgGEMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVL 90
Cdd:cd00200   12 VTCVAFSPD--GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  91 KGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTP 170
Cdd:cd00200   90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 171 AvshQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVW 249
Cdd:cd00200  170 V---ATLTGHTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 444909133 250 DCNTGKCLETLkQGVLDVAHTCAFTPDGKILVSGAADQTRR 290
Cdd:cd00200  247 DLRTGECVQTL-SGHTNSVTSLAWSPDGKRLASGSADGTIR 286
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 68-249 6.61e-14

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 72.04  E-value: 6.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  68 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSF-SPDSRQLASGGWDKRVMLWDVQSGQMLRlLVGHRDSIQSSDF-S 145
Cdd:PLN00181 549 ASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIG-TIKTKANICCVQFpS 627

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 146 PTVNCLATGSWDSTVHIWDLRmvTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTS------SLLIQLK 219
Cdd:PLN00181 628 ESGRSLAFGSADHKVYYYDLR--NPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSisgineTPLHSFM 705

                        170       180       190
                 ....*....|....*....|....*....|
gi 444909133 220 GHVTWVKSIAFSPDELWLASAGYSRMVKVW 249
Cdd:PLN00181 706 GHTNVKNFVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 41-80 5.06e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 5.06e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 444909133    41 SGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 80
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
85-122 2.92e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 2.92e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 444909133   85 KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 122
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
22-288 4.07e-88

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 269.09  E-value: 4.07e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  22 GEMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVS 101
Cdd:COG2319  132 GKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 102 FSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDlrmVTPAVSHQALEGHS 181
Cdd:COG2319  212 FSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD---LATGELLRTLTGHS 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 182 ANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETL 260
Cdd:COG2319  289 GGVNSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL 368

                        250       260
                 ....*....|....*....|....*...
gi 444909133 261 kQGVLDVAHTCAFTPDGKILVSGAADQT 288
Cdd:COG2319  369 -TGHTGAVTSVAFSPDGRTLASGSADGT 395
WD40 COG2319
WD40 repeat [General function prediction only];
21-290 5.05e-84

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 258.30  E-value: 5.05e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  21 GGEMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETV 100
Cdd:COG2319   89 DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSV 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 101 SFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRmvTPAVSHQaLEGH 180
Cdd:COG2319  169 AFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA--TGKLLRT-LTGH 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 181 SANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLET 259
Cdd:COG2319  246 SGSVRSVAFSPDGrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 325

                        250       260       270
                 ....*....|....*....|....*....|.
gi 444909133 260 LKQGVLDVaHTCAFTPDGKILVSGAADQTRR 290
Cdd:COG2319  326 LTGHTGAV-RSVAFSPDGKTLASGSDDGTVR 355
WD40 COG2319
WD40 repeat [General function prediction only];
20-288 9.89e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 237.12  E-value: 9.89e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  20 HGGEMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVET 99
Cdd:COG2319   46 PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRS 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 100 VSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRmvTPAVSHqALEG 179
Cdd:COG2319  126 VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--TGKLLR-TLTG 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 180 HSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLE 258
Cdd:COG2319  203 HTGAVRSVAFSPDGkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLR 282

                        250       260       270
                 ....*....|....*....|....*....|
gi 444909133 259 TLKqGVLDVAHTCAFTPDGKILVSGAADQT 288
Cdd:COG2319  283 TLT-GHSGGVNSVAFSPDGKLLASGSDDGT 311
WD40 COG2319
WD40 repeat [General function prediction only];
22-253 6.11e-75

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 235.19  E-value: 6.11e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  22 GEMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVS 101
Cdd:COG2319  174 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVA 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 102 FSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAvshQALEGHS 181
Cdd:COG2319  254 FSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLL---RTLTGHT 330

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 444909133 182 ANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNT 253
Cdd:COG2319  331 GAVRSVAFSPDGkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-290 3.52e-71

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 221.83  E-value: 3.52e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  11 VRRVKFFGQhgGEMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVL 90
Cdd:cd00200   12 VTCVAFSPD--GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  91 KGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTP 170
Cdd:cd00200   90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 171 AvshQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVW 249
Cdd:cd00200  170 V---ATLTGHTGEVNSVAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 444909133 250 DCNTGKCLETLkQGVLDVAHTCAFTPDGKILVSGAADQTRR 290
Cdd:cd00200  247 DLRTGECVQTL-SGHTNSVTSLAWSPDGKRLASGSADGTIR 286
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-288 4.76e-68

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 213.74  E-value: 4.76e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  48 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 127
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 128 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRmvtPAVSHQALEGHSANISCLCYS-ASGLLASGSWDKTIHI 206
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE---TGKCLTTLRGHTDWVNSVAFSpDGTFVASSSQDGTIKL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 207 WKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLkQGVLDVAHTCAFTPDGKILVSGAAD 286
Cdd:cd00200  162 WDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL-RGHENGVNSVAFSPDGYLLASGSED 240


                 ..
gi 444909133 287 QT 288
Cdd:cd00200  241 GT 242
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-250 2.26e-64

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 204.11  E-value: 2.26e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133   8 TLAVRRVKFFGQhgGEMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCL 87
Cdd:cd00200   51 TGPVRDVAASAD--GTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCL 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  88 RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRM 167
Cdd:cd00200  129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLST 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 168 VTpavSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMV 246
Cdd:cd00200  209 GK---CLGTLRGHENGVNSVAFSPDGyLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTI 285


                 ....
gi 444909133 247 KVWD 250
Cdd:cd00200  286 RIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
25-288 6.28e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 203.99  E-value: 6.28e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  25 LLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSP 104
Cdd:COG2319    9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 105 DSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRmvTPAVSHQaLEGHSANI 184
Cdd:COG2319   89 DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRT-LTGHSGAV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 185 SCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKqG 263
Cdd:COG2319  166 TSVAFSPDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT-G 244

                        250       260
                 ....*....|....*....|....*
gi 444909133 264 VLDVAHTCAFTPDGKILVSGAADQT 288
Cdd:COG2319  245 HSGSVRSVAFSPDGRLLASGSADGT 269
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 86-288 2.98e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 165.20  E-value: 2.98e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  86 CLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 165
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 166 RmvTPAVSHQaLEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSR 244
Cdd:cd00200   81 E--TGECVRT-LTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG 157

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 444909133 245 MVKVWDCNTGKCLETLKQGVLDVaHTCAFTPDGKILVSGAADQT 288
Cdd:cd00200  158 TIKLWDLRTGKCVATLTGHTGEV-NSVAFSPDGEKLLSSSSDGT 200
WD40 COG2319
WD40 repeat [General function prediction only];
59-288 1.49e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 163.93  E-value: 1.49e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  59 RFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDS 138
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 139 IQSSDFSPTVNCLATGSWDSTVHIWDlrmVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQ 217
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWD---LATGLLLRTLTGHTGAVRSVAFSPDGkTLASGSADGTVRLWDLATGKLLRT 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 444909133 218 LKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKqGVLDVAHTCAFTPDGKILVSGAADQT 288
Cdd:COG2319  158 LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKLLASGSADGT 227
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 68-249 6.61e-14

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 72.04  E-value: 6.61e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  68 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSF-SPDSRQLASGGWDKRVMLWDVQSGQMLRlLVGHRDSIQSSDF-S 145
Cdd:PLN00181 549 ASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIG-TIKTKANICCVQFpS 627

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 146 PTVNCLATGSWDSTVHIWDLRmvTPAVSHQALEGHSANISCLCYSASGLLASGSWDKTIHIWKPTTS------SLLIQLK 219
Cdd:PLN00181 628 ESGRSLAFGSADHKVYYYDLR--NPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSMSisgineTPLHSFM 705

                        170       180       190
                 ....*....|....*....|....*....|
gi 444909133 220 GHVTWVKSIAFSPDELWLASAGYSRMVKVW 249
Cdd:PLN00181 706 GHTNVKNFVGLSVSDGYIATGSETNEVFVY 735
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 60-250 1.27e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 62.03  E-value: 1.27e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  60 FSPDGHLFASASCDCTVRLWDvarakCLRVLKG----HQRSVETVSFSPDS---------RQLASGGWDKRVMLWDVQSG 126
Cdd:PLN00181 491 FDRDGEFFATAGVNKKIKIFE-----CESIIKDgrdiHYPVVELASRSKLSgicwnsyikSQVASSNFEGVVQVWDVARS 565

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 127 QMLRLLVGHRDSIQSSDFS---PTVncLATGSWDSTVHIWDlrmVTPAVSHQALEGhSANISCLCY-SASGL-LASGSWD 201
Cdd:PLN00181 566 QLVTEMKEHEKRVWSIDYSsadPTL--LASGSDDGSVKLWS---INQGVSIGTIKT-KANICCVQFpSESGRsLAFGSAD 639

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 444909133 202 KTIHIWKPTTSSL-LIQLKGHVTWVKSIAFSpDELWLASAGYSRMVKVWD 250
Cdd:PLN00181 640 HKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWD 688
PTZ00420 PTZ00420
coronin; Provisional
 76-260 1.42e-09

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 58.81  E-value: 1.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  76 VRLWDVARAKCLRVLKGHQRSVETVSFSP-DSRQLASGGWDKRVMLWDV----QSGQMLR----LLVGHRDSIQSSDFSP 146
Cdd:PTZ00420  56 IRLENQMRKPPVIKLKGHTSSILDLQFNPcFSEILASGSEDLTIRVWEIphndESVKEIKdpqcILKGHKKKISIIDWNP 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 147 -TVNCLATGSWDSTVHIWDLRMvtpavSHQALE-GHSANISCLCYSASGLLASGSW-DKTIHIWKP----TTSSLLIQLK 219
Cdd:PTZ00420 136 mNYYIMCSSGFDSFVNIWDIEN-----EKRAFQiNMPKKLSSLKWNIKGNLLSGTCvGKHMHIIDPrkqeIASSFHIHDG 210

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 444909133 220 GHVT---WVKsiAFSPDELWLASAGYS----RMVKVWDC-NTGKCLETL 260
Cdd:PTZ00420 211 GKNTkniWID--GLGGDDNYILSTGFSknnmREMKLWDLkNTTSALVTM 257
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 41-80 5.06e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 5.06e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 444909133    41 SGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 80
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 85-122 1.02e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 1.02e-08
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 444909133    85 KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 122
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 50-176 1.03e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 56.05  E-value: 1.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  50 GHTGPVKFCRFSP--DGHLFaSASCDCTVRLWDVAR-------AKCLRVLKGHQRSVETVSFSPDSRQ-LASGGWDKRVM 119
Cdd:PTZ00421  73 GQEGPIIDVAFNPfdPQKLF-TASEDGTIMGWGIPEegltqniSDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVN 151

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 120 LWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLR---MVTPAVSHQA 176
Cdd:PTZ00421 152 VWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRdgtIVSSVEAHAS 211
WD40 pfam00400
WD domain, G-beta repeat;
85-122 2.92e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 2.92e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 444909133   85 KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 122
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
42-80 3.89e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 3.89e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 444909133   42 GQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWD 80
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 25-184 7.92e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 53.36  E-value: 7.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  25 LLTGSEDGCVYGWETRSGQL-------LWRLGGHTGPVKFCRFSPDG-HLFASASCDCTVRLWDVARAKCLRVLKGHQRS 96
Cdd:PTZ00421  91 LFTASEDGTIMGWGIPEEGLtqnisdpIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEVIKCHSDQ 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  97 VETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDS-------IQSSDFSPTVNClaTGSWDSTVHIWDLRMVT 169
Cdd:PTZ00421 171 ITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAksqrclwAKRKDLIITLGC--SKSQQRQIMLWDTRKMA 248

                        170
                 ....*....|....*
gi 444909133 170 PAVSHQALEGHSANI 184
Cdd:PTZ00421 249 SPYSTVDLDQSSALF 263
PTZ00421 PTZ00421
coronin; Provisional
 195-301 8.90e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.97  E-value: 8.90e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 195 LASGSWDKTIHIW-------KPTTSSLLIQLKGHVTWVKSIAFSPDEL-WLASAGYSRMVKVWDCNTGKCLETLKQgVLD 266
Cdd:PTZ00421  91 LFTASEDGTIMGWgipeeglTQNISDPIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKC-HSD 169

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 444909133 267 VAHTCAFTPDGKILVSGAADQTRRQIsrtskSPRD 301
Cdd:PTZ00421 170 QITSLEWNLDGSLLCTTSKDKKLNII-----DPRD 199
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 125-164 9.21e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 9.21e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 444909133   125 SGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 164
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 211-250 1.68e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 1.68e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 444909133   211 TSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 250
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 24-199 3.82e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 3.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133  24 MLLTGSEDGCVYGWETRSGQllwRLGGHTGPVKFC--RFSPD-GHLFASASCDCTVRLWDVARAKC-LRVLKGHQRSVET 99
Cdd:PLN00181 590 LLASGSDDGSVKLWSINQGV---SIGTIKTKANICcvQFPSEsGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSY 666

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 100 VSFSpDSRQLASGGWDKRVMLWDVQ---SG---QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVS 173
Cdd:PLN00181 667 VRFV-DSSTLVSSSTDNTLKLWDLSmsiSGineTPLHSFMGHTNVKNFVGLSVSDGYIATGSETNEVFVYHKAFPMPVLS 745

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 444909133 174 HQ--------ALEGHSAN--ISCLCY--SASGLLASGS 199
Cdd:PLN00181 746 YKfktidpvsGLEVDDASqfISSVCWrgQSSTLVAANS 783
WD40 pfam00400
WD domain, G-beta repeat;
126-164 6.96e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 6.96e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 444909133  126 GQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWD 164
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
212-250 7.03e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 7.03e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 444909133  212 SSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWD 250
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 177-208 2.06e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 2.06e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 444909133   177 LEGHSANISCLCYSASG-LLASGSWDKTIHIWK 208
Cdd:smart00320   8 LKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
177-207 3.01e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.01e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 444909133  177 LEGHSANISCLCYSASG-LLASGSWDKTIHIW 207
Cdd:pfam00400   7 LEGHTGSVTSLAFSPDGkLLASGSDDGTVKVW 38
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 59-147 3.59e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 45.41  E-value: 3.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133   59 RFSPDGHLFASASCDCTVRLWDVARAKCLRVLKG-HQRSVETVSFSPDSRQLA----SGGWDKRVMLWDVQSGQMLRLLV 133
Cdd:COG4946   395 VWSPDGKKIAFTDNRGRLWVVDLASGKVRKVDTDgYGDGISDLAWSPDSKWLAyskpGPNQLSQIFLYDVETGKTVQLTD 474

                          90
                  ....*....|....
gi 444909133  134 GhrdsiQSSDFSPT 147
Cdd:COG4946   475 G-----RYDDGSPA 483
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 182-287 7.19e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 7.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 182 ANISCLCYSA--SGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSP-DELWLASAGYSRMVKVWDCNTGKCLE 258
Cdd:PLN00181 533 SKLSGICWNSyiKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIG 612

                         90       100       110
                 ....*....|....*....|....*....|..
gi 444909133 259 TLKQGvldvAHTCA--FTPD-GKILVSGAADQ 287
Cdd:PLN00181 613 TIKTK----ANICCvqFPSEsGRSLAFGSADH 640
RAB3GAP2_N pfam14655
Rab3 GTPase-activating protein regulatory subunit N-terminus; This family includes the ...
 82-137 8.10e-05

Rab3 GTPase-activating protein regulatory subunit N-terminus; This family includes the N-terminus of the Rab3 GTPase-activating protein non-catalytic subunit. Rab3 GTPase-activating protein is a GTPase activating protein with specificity for Rab3 subfamily.


Pssm-ID: 464240  Cd Length: 416  Bit Score: 43.84  E-value: 8.10e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 444909133   82 ARAKCLRVLKGHQRSVETVSFSPDSRQLA---SGGwdkRVMLWDVQSGQMLRLLVGHRD 137
Cdd:pfam14655 297 APLSCRFGLKDSKREGESITLSPSGRLAAvtdSLG---RVLLLDVQAGVAVRLWKGYRD 352
WD40 COG2319
WD40 repeat [General function prediction only];
190-290 1.05e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 190 SASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLkQGVLDVAH 269
Cdd:COG2319    4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATL-LGHTAAVL 82

                         90       100
                 ....*....|....*....|.
gi 444909133 270 TCAFTPDGKILVSGAADQTRR 290
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVR 103
PTZ00420 PTZ00420
coronin; Provisional
 121-207 4.39e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 4.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 444909133 121 WDVQSGQML---RL-----------LVGHRDSIQSSDFSPTVN-CLATGSWDSTVHIWDLRMVTPAVSHQA-----LEGH 180
Cdd:PTZ00420  45 WEVEGGGLIgaiRLenqmrkppvikLKGHTSSILDLQFNPCFSeILASGSEDLTIRVWEIPHNDESVKEIKdpqciLKGH 124

                         90       100
                 ....*....|....*....|....*....
gi 444909133 181 SANISCLCYSASG--LLASGSWDKTIHIW 207
Cdd:PTZ00420 125 KKKISIIDWNPMNyyIMCSSGFDSFVNIW 153
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 28-103 1.94e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 1.94e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 444909133   28 GSEDGCVygWETR-SGQLLW--RLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFS 103
Cdd:pfam12894  13 ATEDGEL--LLHRlNWQRVWtlSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH