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Conserved domains on  [gi|449784879|ref|NP_001263382|]
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importin subunit beta-1 isoform 2 [Homo sapiens]

Protein Classification

importin beta family protein( domain architecture ID 707677)

importin beta family protein may function in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KAP95 super family cl27231
Karyopherin (importin) beta [Intracellular trafficking and secretion];
2-726 4.12e-177

Karyopherin (importin) beta [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5215:

Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 528.35  E-value: 4.12e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879   2 KESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEAT 81
Cdd:COG5215  151 KCESLGICGYHCESEAPEDLIQMSNVILFAIVMGALKNETTSAVRLAALKALMDSLMFVQGNFCYEEERNYFMQVVCEAT 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879  82 QCPDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQgrp 161
Cdd:COG5215  231 QGNDEELQHAAFGCLNKIMMLYYKFMQSYMENALAALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEV--- 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 162 PEHTSKFyAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAA 241
Cdd:COG5215  308 PAQNHGF-ARAAVADVLPELLSLLEKQGEDYYGDDWNPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNIRSESWANREAA 386

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 242 VMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRV 321
Cdd:COG5215  387 VMAFGSVMHGPCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHLVLEVSASLIGLMDCPFR 466

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 322 ASNVCWAFSSLAEaayEAADVADDQEEPatycLSSSFELIVQKLLETTDRPDgHQNNLRSSAYESLMEIVKNSAKDCYPA 401
Cdd:COG5215  467 SINCSWRKENLVD---HIAKAVREVESF----LAKFYLAILNALVKGTELAL-NESNLRVSLFSALGTLILICPDAVSDI 538

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 402 VQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKvQHQDALQISDVVMASLLRMFQSTAgSGGVQE 481
Cdd:COG5215  539 LAGFYDYTSKKLDECISVLGQILATEDQLLVEELQSNYIGVLEAIIRT-RRRDIEDVEDQLMELFIRILESTK-PTTAFG 616

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 482 DALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLkNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVH 561
Cdd:COG5215  617 DVYTAISALSTSLEERFEQYASKFIPYLTRAL-NCTDRFVLNSAVGLVGDLANTLGTDFNIYADVLMSSLVQCLSSEATH 695

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 562 RSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGlkgdqenVHPD 641
Cdd:COG5215  696 RDLKPAILSVFGDIALAIGANFESYLDMIMMLFQQASELDPHSDEVYVDDYRKNAVQLVNCAYVGIGDS-------SKNR 768

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 642 VMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKA-KTLATWA 720
Cdd:COG5215  769 VRSVLPYVISIFHKIGMIAEDPNGSEAHTRAALGLIGDLAGMFPKGELKFGLDEDWVKDFLYGMMKKISSQQtKDSARWA 848


                 ....*.
gi 449784879 721 TKELRK 726
Cdd:COG5215  849 AEQVKR 854
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
2-726 4.12e-177

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 528.35  E-value: 4.12e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879   2 KESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEAT 81
Cdd:COG5215  151 KCESLGICGYHCESEAPEDLIQMSNVILFAIVMGALKNETTSAVRLAALKALMDSLMFVQGNFCYEEERNYFMQVVCEAT 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879  82 QCPDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQgrp 161
Cdd:COG5215  231 QGNDEELQHAAFGCLNKIMMLYYKFMQSYMENALAALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEV--- 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 162 PEHTSKFyAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAA 241
Cdd:COG5215  308 PAQNHGF-ARAAVADVLPELLSLLEKQGEDYYGDDWNPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNIRSESWANREAA 386

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 242 VMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRV 321
Cdd:COG5215  387 VMAFGSVMHGPCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHLVLEVSASLIGLMDCPFR 466

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 322 ASNVCWAFSSLAEaayEAADVADDQEEPatycLSSSFELIVQKLLETTDRPDgHQNNLRSSAYESLMEIVKNSAKDCYPA 401
Cdd:COG5215  467 SINCSWRKENLVD---HIAKAVREVESF----LAKFYLAILNALVKGTELAL-NESNLRVSLFSALGTLILICPDAVSDI 538

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 402 VQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKvQHQDALQISDVVMASLLRMFQSTAgSGGVQE 481
Cdd:COG5215  539 LAGFYDYTSKKLDECISVLGQILATEDQLLVEELQSNYIGVLEAIIRT-RRRDIEDVEDQLMELFIRILESTK-PTTAFG 616

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 482 DALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLkNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVH 561
Cdd:COG5215  617 DVYTAISALSTSLEERFEQYASKFIPYLTRAL-NCTDRFVLNSAVGLVGDLANTLGTDFNIYADVLMSSLVQCLSSEATH 695

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 562 RSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGlkgdqenVHPD 641
Cdd:COG5215  696 RDLKPAILSVFGDIALAIGANFESYLDMIMMLFQQASELDPHSDEVYVDDYRKNAVQLVNCAYVGIGDS-------SKNR 768

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 642 VMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKA-KTLATWA 720
Cdd:COG5215  769 VRSVLPYVISIFHKIGMIAEDPNGSEAHTRAALGLIGDLAGMFPKGELKFGLDEDWVKDFLYGMMKKISSQQtKDSARWA 848


                 ....*.
gi 449784879 721 TKELRK 726
Cdd:COG5215  849 AEQVKR 854
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 235-290 4.81e-12

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 61.23  E-value: 4.81e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 449784879  235 WRYRDAAVMAFGCILEGpEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRI 290
Cdd:pfam13513   1 WRVREAAALALGSLAEG-GPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
 
Name Accession Description Interval E-value
KAP95 COG5215
Karyopherin (importin) beta [Intracellular trafficking and secretion];
2-726 4.12e-177

Karyopherin (importin) beta [Intracellular trafficking and secretion];


Pssm-ID: 227540 [Multi-domain]  Cd Length: 858  Bit Score: 528.35  E-value: 4.12e-177
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879   2 KESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEAT 81
Cdd:COG5215  151 KCESLGICGYHCESEAPEDLIQMSNVILFAIVMGALKNETTSAVRLAALKALMDSLMFVQGNFCYEEERNYFMQVVCEAT 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879  82 QCPDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQgrp 161
Cdd:COG5215  231 QGNDEELQHAAFGCLNKIMMLYYKFMQSYMENALAALTGRFMKSQNDEVAIQAVEFWSTICEEEIDGEMEDKYLPEV--- 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 162 PEHTSKFyAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAA 241
Cdd:COG5215  308 PAQNHGF-ARAAVADVLPELLSLLEKQGEDYYGDDWNPSMAASSCLQLFAQLKGDKIMRPVLGFVEQNIRSESWANREAA 386

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 242 VMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRV 321
Cdd:COG5215  387 VMAFGSVMHGPCEDCLTKIVPQALPGIENEMSDSCLWVKSTTAWCFGAIADHVAMIISPCGHLVLEVSASLIGLMDCPFR 466

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 322 ASNVCWAFSSLAEaayEAADVADDQEEPatycLSSSFELIVQKLLETTDRPDgHQNNLRSSAYESLMEIVKNSAKDCYPA 401
Cdd:COG5215  467 SINCSWRKENLVD---HIAKAVREVESF----LAKFYLAILNALVKGTELAL-NESNLRVSLFSALGTLILICPDAVSDI 538

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 402 VQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKvQHQDALQISDVVMASLLRMFQSTAgSGGVQE 481
Cdd:COG5215  539 LAGFYDYTSKKLDECISVLGQILATEDQLLVEELQSNYIGVLEAIIRT-RRRDIEDVEDQLMELFIRILESTK-PTTAFG 616

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 482 DALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLkNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVH 561
Cdd:COG5215  617 DVYTAISALSTSLEERFEQYASKFIPYLTRAL-NCTDRFVLNSAVGLVGDLANTLGTDFNIYADVLMSSLVQCLSSEATH 695

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 562 RSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGlkgdqenVHPD 641
Cdd:COG5215  696 RDLKPAILSVFGDIALAIGANFESYLDMIMMLFQQASELDPHSDEVYVDDYRKNAVQLVNCAYVGIGDS-------SKNR 768

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 642 VMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKA-KTLATWA 720
Cdd:COG5215  769 VRSVLPYVISIFHKIGMIAEDPNGSEAHTRAALGLIGDLAGMFPKGELKFGLDEDWVKDFLYGMMKKISSQQtKDSARWA 848


                 ....*.
gi 449784879 721 TKELRK 726
Cdd:COG5215  849 AEQVKR 854
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 235-290 4.81e-12

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 61.23  E-value: 4.81e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 449784879  235 WRYRDAAVMAFGCILEGpEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRI 290
Cdd:pfam13513   1 WRVREAAALALGSLAEG-GPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 265-294 1.87e-04

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 39.05  E-value: 1.87e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 449784879  265 MPTLIELMKDPSVVVRDTAAWTVGRICELL 294
Cdd:pfam02985   2 LPLLLKLLNDPSPEVREAAAEALGELAEVL 31
HEAT COG1413
HEAT repeat [General function prediction only];
220-290 3.72e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.15  E-value: 3.72e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 449784879 220 PHVLPFIKEHIKNPDWRYRDAAVMAFGCIleGPEPsqlkplviqAMPTLIELMKDPSVVVRDTAAWTVGRI 290
Cdd:COG1413   77 PEAVPALIAALKDEDPEVRRAAAEALGRL--GDPA---------AVPALLEALKDPDWEVRRAAARALGRL 136
HEAT COG1413
HEAT repeat [General function prediction only];
220-333 5.73e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.77  E-value: 5.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 220 PHVLPFIKEHIKNPDWRYRDAAVMAFGCIleGPEpsqlkplviQAMPTLIELMKDPSVVVRDTAAWTVGRICEllpEAAI 299
Cdd:COG1413   46 PRAVPALLEALKDPDPEVRAAAAEALGRI--GDP---------EAVPALIAALKDEDPEVRRAAAEALGRLGD---PAAV 111

                         90       100       110
                 ....*....|....*....|....*....|....
gi 449784879 300 NdvYLAPLLQclieglSAEPRVASNVCWAFSSLA 333
Cdd:COG1413  112 P--ALLEALK------DPDWEVRRAAARALGRLG 137
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 279-332 2.05e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 36.96  E-value: 2.05e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 449784879  279 VRDTAAWTVGRICELLPEAAINdvYLAPLLQCLIEGL-SAEPRVASNVCWAFSSL 332
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAP--AVPELLPALLPLLnDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
238-390 4.97e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 38.07  E-value: 4.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 238 RDAAVMAFGcILEGPEpsqlkplviqAMPTLIELMKDPSVVVRDTAAWTVGRICEllPEAaindvyLAPLLQCLiegLSA 317
Cdd:COG1413    2 RRAAARALG-RLGDPA----------AVPALIAALADEDPDVRAAAARALGRLGD--PRA------VPALLEAL---KDP 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 449784879 318 EPRVASNVCWAFSSL-AEAAYEA-ADVADDQEEP----ATYCLSS-SFELIVQKLLETTDRPDGhqnNLRSSAYESLMEI 390
Cdd:COG1413   60 DPEVRAAAAEALGRIgDPEAVPAlIAALKDEDPEvrraAAEALGRlGDPAAVPALLEALKDPDW---EVRRAAARALGRL 136
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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