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Conserved domains on  [gi|485836844|ref|NP_001264899|]
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integrin alpha-6 isoform 2 precursor [Mus musculus]

Protein Classification

Int_alpha and Integrin_alpha2 domain-containing protein( domain architecture ID 12192626)

protein containing domains FG-GAP, Int_alpha, and Integrin_alpha2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 465-939 1.87e-168

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


:

Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 503.01  E-value: 1.87e-168
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485836844   465 RPVINILKTITVTPNRIDLRQKSmCGSPSG--ICLKVKACFEYTAKPsGYNPPISILGILEAEKERRKsGLSSRVQFrNQ 542
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKN-CTLTGTpvSCFTVRACFSYTGKP-IPNPSLVLNYELELDRQKKK-GLPPRVLF-LD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485836844   543 GSEPKYTQELTLNRQKQRACMEETLWLQENIRDKLRPIPITASVEIQEPssRRRVNSLPEVLPILNSNEAKTVQTDVHFL 622
Cdd:pfam08441   77 SQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRVD--PRAPSDLPGLKPILDQNQPSTVQEQANFL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485836844   623 KEgCGDDNVCNSNLKLEYKFGTREGNqdkfsylpiqkgiPELVLKDQKDIALEITVTNspsdprnprkDGDDAHEAKLIA 702
Cdd:pfam08441  155 KD-CGEDNVCVPDLQLSAKFDSRESD-------------EPLLLGDDNDLALEITVTN----------LGEDAYEAELYV 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485836844   703 TFPDTLTYSAYRelRAFPEKQLSCVANQNGS--QADCELGNPFKRNSSVTFYLILSTTEVTFDTTDLDINLKLETTSNQD 780
Cdd:pfam08441  211 TLPPGLDYSGVR--REGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQN 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485836844   781 -NLAPITAKAKVVIELLLSVSGVAKPSQVyFGGTVVGEQAMK--SEDEVGSLIEYEFRVINLGKPlkNLGTATLNIQWPK 857
Cdd:pfam08441  289 sNSNPVSLKVPVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPY 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485836844   858 EISNGKWLLYLMKVEskGLEQIVCEPHNEINYLKLKESHNSRKKRELPEKQIDDSRKFSLFPERKYQT----LNCSVNVR 933
Cdd:pfam08441  366 ELSNGKWLLYLLDVQ--GQGKGECSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTasvlLSCDSGAR 443


                   ....*.
gi 485836844   934 CVNIRC 939
Cdd:pfam08441  444 CVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 374-425 1.35e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 68.94  E-value: 1.35e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 485836844    374 DSMFGISVKNIGDINQDGYPDIAVGAPYDD----LGKVFIYHGSPTGIITKPTQVL 425
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANdageTGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 316-354 7.86e-10

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


:

Pssm-ID: 460357  Cd Length: 36  Bit Score: 54.82  E-value: 7.86e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 485836844   316 FGYDVAVVDLNADGWQDIVIGAPQYFDRDgevGGAVYVY 354
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 40-100 1.14e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 49.30  E-value: 1.14e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 485836844     40 PGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEAlplqrANRTGGLYSCDITSRG-PCTRIEFD 100
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRAND-----AGETGAVYVYFGSSGGgNSIPLQNL 57
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 254-292 6.94e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.90  E-value: 6.94e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 485836844    254 ANSYLGFSLDSGkGIVSKDDIT-FVSGAPRANHS---GAVVLL 292
Cdd:smart00191    1 PGSYFGYSVAGV-GDVNGDGYPdLLVGAPRANDAgetGAVYVY 42
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 431-454 1.54e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


:

Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.74  E-value: 1.54e-03
                            10        20
                    ....*....|....*....|....
gi 485836844    431 YFGYSIAGNMDLDRNSYPDLAVGS 454
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGA 27
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 465-939 1.87e-168

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 503.01  E-value: 1.87e-168
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485836844   465 RPVINILKTITVTPNRIDLRQKSmCGSPSG--ICLKVKACFEYTAKPsGYNPPISILGILEAEKERRKsGLSSRVQFrNQ 542
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKN-CTLTGTpvSCFTVRACFSYTGKP-IPNPSLVLNYELELDRQKKK-GLPPRVLF-LD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485836844   543 GSEPKYTQELTLNRQKQRACMEETLWLQENIRDKLRPIPITASVEIQEPssRRRVNSLPEVLPILNSNEAKTVQTDVHFL 622
Cdd:pfam08441   77 SQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRVD--PRAPSDLPGLKPILDQNQPSTVQEQANFL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485836844   623 KEgCGDDNVCNSNLKLEYKFGTREGNqdkfsylpiqkgiPELVLKDQKDIALEITVTNspsdprnprkDGDDAHEAKLIA 702
Cdd:pfam08441  155 KD-CGEDNVCVPDLQLSAKFDSRESD-------------EPLLLGDDNDLALEITVTN----------LGEDAYEAELYV 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485836844   703 TFPDTLTYSAYRelRAFPEKQLSCVANQNGS--QADCELGNPFKRNSSVTFYLILSTTEVTFDTTDLDINLKLETTSNQD 780
Cdd:pfam08441  211 TLPPGLDYSGVR--REGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQN 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485836844   781 -NLAPITAKAKVVIELLLSVSGVAKPSQVyFGGTVVGEQAMK--SEDEVGSLIEYEFRVINLGKPlkNLGTATLNIQWPK 857
Cdd:pfam08441  289 sNSNPVSLKVPVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPY 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485836844   858 EISNGKWLLYLMKVEskGLEQIVCEPHNEINYLKLKESHNSRKKRELPEKQIDDSRKFSLFPERKYQT----LNCSVNVR 933
Cdd:pfam08441  366 ELSNGKWLLYLLDVQ--GQGKGECSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTasvlLSCDSGAR 443


                   ....*.
gi 485836844   934 CVNIRC 939
Cdd:pfam08441  444 CVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 374-425 1.35e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 68.94  E-value: 1.35e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 485836844    374 DSMFGISVKNIGDINQDGYPDIAVGAPYDD----LGKVFIYHGSPTGIITKPTQVL 425
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANdageTGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 316-354 7.86e-10

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 54.82  E-value: 7.86e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 485836844   316 FGYDVAVVDLNADGWQDIVIGAPQYFDRDgevGGAVYVY 354
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 314-359 1.37e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 54.69  E-value: 1.37e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 485836844    314 SSFGYDVA-VVDLNADGWQDIVIGAPQYFdrDGEVGGAVYVYINQQG 359
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRAN--DAGETGAVYVYFGSSG 47
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 40-100 1.14e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 49.30  E-value: 1.14e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 485836844     40 PGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEAlplqrANRTGGLYSCDITSRG-PCTRIEFD 100
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRAND-----AGETGAVYVYFGSSGGgNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 377-410 1.85e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 45.19  E-value: 1.85e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 485836844   377 FGISVkNIGDINQDGYPDIAVGAPYDDL---GKVFIY 410
Cdd:pfam01839    1 FGYSV-AVGDLNGDGYADLAVGAPGEGGagaGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 254-292 6.94e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.90  E-value: 6.94e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 485836844    254 ANSYLGFSLDSGkGIVSKDDIT-FVSGAPRANHS---GAVVLL 292
Cdd:smart00191    1 PGSYFGYSVAGV-GDVNGDGYPdLLVGAPRANDAgetGAVYVY 42
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 431-454 1.54e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.74  E-value: 1.54e-03
                            10        20
                    ....*....|....*....|....
gi 485836844    431 YFGYSIAGNMDLDRNSYPDLAVGS 454
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGA 27
 
Name Accession Description Interval E-value
Integrin_alpha2 pfam08441
Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C ...
 465-939 1.87e-168

Integrin alpha; This domain is found in integrin alpha and integrin alpha precursors to the C terminus of a number of pfam01839 repeats and to the N-terminus of the pfam00357 cytoplasmic region. This region is composed of three immunoglobulin-like domains.


Pssm-ID: 462478 [Multi-domain]  Cd Length: 449  Bit Score: 503.01  E-value: 1.87e-168
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485836844   465 RPVINILKTITVTPNRIDLRQKSmCGSPSG--ICLKVKACFEYTAKPsGYNPPISILGILEAEKERRKsGLSSRVQFrNQ 542
Cdd:pfam08441    1 RPVVSVSASLQVEPNSINPEKKN-CTLTGTpvSCFTVRACFSYTGKP-IPNPSLVLNYELELDRQKKK-GLPPRVLF-LD 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485836844   543 GSEPKYTQELTLNRQKQRACMEETLWLQENIRDKLRPIPITASVEIQEPssRRRVNSLPEVLPILNSNEAKTVQTDVHFL 622
Cdd:pfam08441   77 SQQPSLTGTLVLLSQGRKVCRTTKAYLRDEFRDKLSPIVISLNYSLRVD--PRAPSDLPGLKPILDQNQPSTVQEQANFL 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485836844   623 KEgCGDDNVCNSNLKLEYKFGTREGNqdkfsylpiqkgiPELVLKDQKDIALEITVTNspsdprnprkDGDDAHEAKLIA 702
Cdd:pfam08441  155 KD-CGEDNVCVPDLQLSAKFDSRESD-------------EPLLLGDDNDLALEITVTN----------LGEDAYEAELYV 210

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485836844   703 TFPDTLTYSAYRelRAFPEKQLSCVANQNGS--QADCELGNPFKRNSSVTFYLILSTTEVTFDTTDLDINLKLETTSNQD 780
Cdd:pfam08441  211 TLPPGLDYSGVR--REGSEKQLSCTAKKENStrQVVCDLGNPMKRGTQVTFGLRFSVSGLELSTEELSFDLQIRSTNEQN 288

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485836844   781 -NLAPITAKAKVVIELLLSVSGVAKPSQVyFGGTVVGEQAMK--SEDEVGSLIEYEFRVINLGKPlkNLGTATLNIQWPK 857
Cdd:pfam08441  289 sNSNPVSLKVPVVAEAQLSLSGVSKPDQV-VGGSVKGESAMKprSEEDIGPLVEHTYEVINNGPS--TVSGASLEISWPY 365

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 485836844   858 EISNGKWLLYLMKVEskGLEQIVCEPHNEINYLKLKESHNSRKKRELPEKQIDDSRKFSLFPERKYQT----LNCSVNVR 933
Cdd:pfam08441  366 ELSNGKWLLYLLDVQ--GQGKGECSPQNEINPLNLTQSLESSKPLRTSRVHHVVKRRDVLKSEKATQTasvlLSCDSGAR 443


                   ....*.
gi 485836844   934 CVNIRC 939
Cdd:pfam08441  444 CVVIRC 449
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 374-425 1.35e-14

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 68.94  E-value: 1.35e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 485836844    374 DSMFGISVKNIGDINQDGYPDIAVGAPYDD----LGKVFIYHGSPTGIITKPTQVL 425
Cdd:smart00191    2 GSYFGYSVAGVGDVNGDGYPDLLVGAPRANdageTGAVYVYFGSSGGGNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 316-354 7.86e-10

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 54.82  E-value: 7.86e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 485836844   316 FGYDVAVVDLNADGWQDIVIGAPQYFDRDgevGGAVYVY 354
Cdd:pfam01839    1 FGYSVAVGDLNGDGYADLAVGAPGEGGAG---AGAVYVL 36
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 314-359 1.37e-09

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 54.69  E-value: 1.37e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 485836844    314 SSFGYDVA-VVDLNADGWQDIVIGAPQYFdrDGEVGGAVYVYINQQG 359
Cdd:smart00191    3 SYFGYSVAgVGDVNGDGYPDLLVGAPRAN--DAGETGAVYVYFGSSG 47
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 324-397 1.41e-08

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 52.23  E-value: 1.41e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 485836844   324 DLNADGWQDIVIGAPqyfdrdgevgGAVYVYINQ-QGKWSNVKPIRLNGTKDSMfGISVkniGDINQDGYPDIAV 397
Cdd:pfam13517    1 DLDGDGKLDLVVAND----------GGLRLYLNNgDGTFTFITSVSLGGGGGGL-SVAV---GDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 40-100 1.14e-07

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 49.30  E-value: 1.14e-07
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 485836844     40 PGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEAlplqrANRTGGLYSCDITSRG-PCTRIEFD 100
Cdd:smart00191    1 PGSYFGYSVAGVGDVNGDGYPDLLVGAPRAND-----AGETGAVYVYFGSSGGgNSIPLQNL 57
FG-GAP pfam01839
FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven ...
 377-410 1.85e-06

FG-GAP repeat; This family contains the extracellular repeat that is found in up to seven copies in alpha integrins. This repeat has been predicted to fold into a beta propeller structure. The repeat is called the FG-GAP repeat after two conserved motifs in the repeat. The FG-GAP repeats are found in the N terminus of integrin alpha chains, a region that has been shown to be important for ligand binding. A putative Ca2+ binding motif is found in some of the repeats.


Pssm-ID: 460357  Cd Length: 36  Bit Score: 45.19  E-value: 1.85e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 485836844   377 FGISVkNIGDINQDGYPDIAVGAPYDDL---GKVFIY 410
Cdd:pfam01839    1 FGYSV-AVGDLNGDGYADLAVGAPGEGGagaGAVYVL 36
FG-GAP_3 pfam13517
FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...
 386-452 3.56e-05

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.


Pssm-ID: 433275 [Multi-domain]  Cd Length: 61  Bit Score: 42.60  E-value: 3.56e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 485836844   386 DINQDGYPDIAVGAPyddlGKVFIYHGSPTGIITKPTQVLeGTSPYFGYSIAGnMDLDRNSYPDLAV 452
Cdd:pfam13517    1 DLDGDGKLDLVVAND----GGLRLYLNNGDGTFTFITSVS-LGGGGGGLSVAV-GDLDGDGRLDLLV 61
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 254-292 6.94e-04

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 38.90  E-value: 6.94e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 485836844    254 ANSYLGFSLDSGkGIVSKDDIT-FVSGAPRANHS---GAVVLL 292
Cdd:smart00191    1 PGSYFGYSVAGV-GDVNGDGYPdLLVGAPRANDAgetGAVYVY 42
Int_alpha smart00191
Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate ...
 431-454 1.54e-03

Integrin alpha (beta-propellor repeats); Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Alpha integrins are proposed to contain a domain containing a 7-fold repeat that adopts a beta-propellor fold. Some of these domains contain an inserted von Willebrand factor type-A domain. Some repeats contain putative calcium-binding sites. The 7-fold repeat domain is homologous to a similar domain in phosphatidylinositol-glycan-specific phospholipase D.


Pssm-ID: 214549 [Multi-domain]  Cd Length: 57  Bit Score: 37.74  E-value: 1.54e-03
                            10        20
                    ....*....|....*....|....
gi 485836844    431 YFGYSIAGNMDLDRNSYPDLAVGS 454
Cdd:smart00191    4 YFGYSVAGVGDVNGDGYPDLLVGA 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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