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Conserved domains on  [gi|507144070|ref|NP_001265228|]
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WD repeat domain phosphoinositide-interacting protein 2 isoform f [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-216 1.92e-12

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 1.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070   2 KVLHTIREtppNPAGLCALSINNDNCYLAYpGSATiGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGT 81
Cdd:COG2319  153 KLLRTLTG---HSGAVTSVAFSPDGKLLAS-GSDD-GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070  82 ViRVFSIPEGQKLFEFRRGVKrcvSICSLAFSMDGMFLSASSNTETVHIFKLETvkekpPEEPTTWTGYFGKVLmaSTSY 161
Cdd:COG2319  228 V-RLWDLATGKLLRTLTGHSG---SVRSVAFSPDGRLLASGSADGTVRLWDLAT-----GELLRTLTGHSGGVN--SVAF 296

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 507144070 162 LPSqvtemfnqGRAFA------TVRL----------PFCGHKN-ICSLATIQKIPRLLVGAADGYLYMYNLD 216
Cdd:COG2319  297 SPD--------GKLLAsgsddgTVRLwdlatgkllrTLTGHTGaVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-216 1.92e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 1.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070   2 KVLHTIREtppNPAGLCALSINNDNCYLAYpGSATiGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGT 81
Cdd:COG2319  153 KLLRTLTG---HSGAVTSVAFSPDGKLLAS-GSDD-GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070  82 ViRVFSIPEGQKLFEFRRGVKrcvSICSLAFSMDGMFLSASSNTETVHIFKLETvkekpPEEPTTWTGYFGKVLmaSTSY 161
Cdd:COG2319  228 V-RLWDLATGKLLRTLTGHSG---SVRSVAFSPDGRLLASGSADGTVRLWDLAT-----GELLRTLTGHSGGVN--SVAF 296

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 507144070 162 LPSqvtemfnqGRAFA------TVRL----------PFCGHKN-ICSLATIQKIPRLLVGAADGYLYMYNLD 216
Cdd:COG2319  297 SPD--------GKLLAsgsddgTVRLwdlatgkllrTLTGHTGaVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-219 1.67e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 1.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070  40 VQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTvIRVFSIPEGQKLFEFrRGVKRcvSICSLAFSMDGMFL 119
Cdd:cd00200   75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT-IKVWDVETGKCLTTL-RGHTD--WVNSVAFSPDGTFV 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070 120 SASSNTETVHIFKLETVKEKppeepTTWTGYFGKVLmaSTSYLPSqvtemfnqGRAFA------TVRL----------PF 183
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCV-----ATLTGHTGEVN--SVAFSPD--------GEKLLssssdgTIKLwdlstgkclgTL 215

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 507144070 184 CGHKN-ICSLATIQKiPRLLVGAA-DGYLYMYNLDPQE 219
Cdd:cd00200  216 RGHENgVNSVAFSPD-GYLLASGSeDGTIRVWDLRTGE 252
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
2-216 1.92e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 1.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070   2 KVLHTIREtppNPAGLCALSINNDNCYLAYpGSATiGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGT 81
Cdd:COG2319  153 KLLRTLTG---HSGAVTSVAFSPDGKLLAS-GSDD-GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGT 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070  82 ViRVFSIPEGQKLFEFRRGVKrcvSICSLAFSMDGMFLSASSNTETVHIFKLETvkekpPEEPTTWTGYFGKVLmaSTSY 161
Cdd:COG2319  228 V-RLWDLATGKLLRTLTGHSG---SVRSVAFSPDGRLLASGSADGTVRLWDLAT-----GELLRTLTGHSGGVN--SVAF 296

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 507144070 162 LPSqvtemfnqGRAFA------TVRL----------PFCGHKN-ICSLATIQKIPRLLVGAADGYLYMYNLD 216
Cdd:COG2319  297 SPD--------GKLLAsgsddgTVRLwdlatgkllrTLTGHTGaVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
19-154 1.76e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 1.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070  19 ALSINNDNCYLAYpGSATiGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTViRVFSIPEGQKLFEFR 98
Cdd:COG2319  251 SVAFSPDGRLLAS-GSAD-GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTV-RLWDLATGKLLRTLT 327

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 507144070  99 RGVKRcvsICSLAFSMDGMFLSASSNTETVHIFKLETvkekpPEEPTTWTGYFGKV 154
Cdd:COG2319  328 GHTGA---VRSVAFSPDGKTLASGSDDGTVRLWDLAT-----GELLRTLTGHTGAV 375
WD40 COG2319
WD40 repeat [General function prediction only];
7-135 5.84e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.54  E-value: 5.84e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070   7 IRETPPNPAGLCALSINNDNCYLAYpGSATiGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTViRVF 86
Cdd:COG2319  281 LRTLTGHSGGVNSVAFSPDGKLLAS-GSDD-GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV-RLW 357

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 507144070  87 SIPEGQKLFEFRRGVKRcvsICSLAFSMDGMFLSASSNTETVHIFKLET 135
Cdd:COG2319  358 DLATGELLRTLTGHTGA---VTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
38-154 7.81e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.15  E-value: 7.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070  38 GEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTViRVFSIPEGQKLFEFrRGVKRCVSicSLAFSMDGM 117
Cdd:COG2319  100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV-RLWDLATGKLLRTL-TGHSGAVT--SVAFSPDGK 175

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 507144070 118 FLSASSNTETVHIFKLETvkekpPEEPTTWTGYFGKV 154
Cdd:COG2319  176 LLASGSDDGTVRLWDLAT-----GKLLRTLTGHTGAV 207
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 40-219 1.67e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 1.67e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070  40 VQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTvIRVFSIPEGQKLFEFrRGVKRcvSICSLAFSMDGMFL 119
Cdd:cd00200   75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT-IKVWDVETGKCLTTL-RGHTD--WVNSVAFSPDGTFV 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070 120 SASSNTETVHIFKLETVKEKppeepTTWTGYFGKVLmaSTSYLPSqvtemfnqGRAFA------TVRL----------PF 183
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCV-----ATLTGHTGEVN--SVAFSPD--------GEKLLssssdgTIKLwdlstgkclgTL 215

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 507144070 184 CGHKN-ICSLATIQKiPRLLVGAA-DGYLYMYNLDPQE 219
Cdd:cd00200  216 RGHENgVNSVAFSPD-GYLLASGSeDGTIRVWDLRTGE 252
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-139 1.08e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 1.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070  18 CALSINNDNCYLAypGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTvIRVFSIPEGQKLFEF 97
Cdd:cd00200  139 NSVAFSPDGTFVA--SSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTL 215

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 507144070  98 RRgvkRCVSICSLAFSMDGMFLSASSNTETVHIFKLETVKEK 139
Cdd:cd00200  216 RG---HENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECV 254
WD40 COG2319
WD40 repeat [General function prediction only];
34-154 1.10e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 1.10e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070  34 SATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTViRVFSIPEGQKLFEFRRGVKrcvSICSLAFS 113
Cdd:COG2319   54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV-RLWDLATGLLLRTLTGHTG---AVRSVAFS 129

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 507144070 114 MDGMFLSASSNTETVHIFKLETvkekpPEEPTTWTGYFGKV 154
Cdd:COG2319  130 PDGKTLASGSADGTVRLWDLAT-----GKLLRTLTGHSGAV 165
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-229 5.04e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 5.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070  54 IPAHDSPLAALAFDASGTKLATASEKGTvIRVFSIPEGQKLFEFR---RGVKRCVSICslafsmDGMFLSASSNTETVHI 130
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGT-IKVWDLETGELLRTLKghtGPVRDVAASA------DGTYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070 131 FKLETvkekpPEEPTTWTGYFGKVL---------MASTSYLPSQV----TEMFNQGRAFAtvrlpfcGHKN-ICSLATIQ 196
Cdd:cd00200   78 WDLET-----GECVRTLTGHTSYVSsvafspdgrILSSSSRDKTIkvwdVETGKCLTTLR-------GHTDwVNSVAFSP 145

                        170       180       190
                 ....*....|....*....|....*....|...
gi 507144070 197 KIPRLLVGAADGYLYMYNLDpqEGGECALMKQH 229
Cdd:cd00200  146 DGTFVASSSQDGTIKLWDLR--TGKCVATLTGH 176
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
38-131 3.30e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 41.22  E-value: 3.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070  38 GEVQVFDTINLRAANMIPAHDSPlAALAFDASGTKLATASEKGTVIRVFSIPEGQKLFEFRRGvkrcVSICSLAFSMDGM 117
Cdd:COG3391   90 GRVSVIDLATGKVVATIPVGGGP-RGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG----AGPHGIAVDPDGK 164

                         90
                 ....*....|....*
gi 507144070 118 FL-SASSNTETVHIF 131
Cdd:COG3391  165 RLyVANSGSNTVSVI 179
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-87 9.46e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 9.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070   2 KVLHTIREtppNPAGLCALSINNDNCYLAypGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGT 81
Cdd:cd00200  210 KCLGTLRG---HENGVNSVAFSPDGYLLA--SGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT 284


                 ....*.
gi 507144070  82 vIRVFS 87
Cdd:cd00200  285 -IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
6-89 1.26e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.28  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070   6 TIRETPPNPAGLCALSINNDNCYLAYpGSATiGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTvIRV 85
Cdd:COG2319  322 LLRTLTGHTGAVRSVAFSPDGKTLAS-GSDD-GTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGT-VRL 398


                 ....
gi 507144070  86 FSIP 89
Cdd:COG2319  399 WDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-138 2.37e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 38.86  E-value: 2.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070  18 CALSINNDNCYLAypGSATIGEVQVFDTINLRAANMIPAHDSPLAALAFDASGTKLATASEKGTvIRVFSIPEGQ--KLF 95
Cdd:cd00200   97 SSVAFSPDGRILS--SSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT-IKLWDLRTGKcvATL 173

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 507144070  96 EFRRGvkrcvSICSLAFSMDGMFLSASSNTETVHIFKLETVKE 138
Cdd:cd00200  174 TGHTG-----EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC 211
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
1-91 4.39e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 38.14  E-value: 4.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 507144070   1 MKVLHTIrETPPNPAGLcALSINNDNCYLAYPGSATIGE-VQVFDTINLRAANMIPAHDSPLaALAFDASGTKL------ 73
Cdd:COG3391  142 GKVVATI-PVGAGPHGI-AVDPDGKRLYVANSGSNTVSViVSVIDTATGKVVATIPVGGGPV-GVAVSPDGRRLyvanrg 218

                         90
                 ....*....|....*....
gi 507144070  74 -ATASEKGTVIRVFSIPEG 91
Cdd:COG3391  219 sNTSNGGSNTVSVIDLATL 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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