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Conserved domains on  [gi|508083035|ref|NP_001265233|]
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diablo IAP-binding mitochondrial protein isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Smac_DIABLO super family cl09466
Second Mitochondria-derived Activator of Caspases; Second Mitochondria-derived Activator of ...
8-186 2.10e-97

Second Mitochondria-derived Activator of Caspases; Second Mitochondria-derived Activator of Caspases promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway, and by opposing the inhibitory activity of inhibitor of apoptosis proteins (XIAP-BIR3). The protein assumes an elongated three-helix bundle structure, and forms a dimer in solution.


The actual alignment was detected with superfamily member pfam09057:

Pssm-ID: 462664  Cd Length: 231  Bit Score: 281.73  E-value: 2.10e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083035    8 QKSEPhSLSSEALMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLTSLYRQYTSLLGKMNSEEEDEVWQVIIGAR 87
Cdd:pfam09057  45 QKSEP-SLSHEALIRRAVSLVTDSANTFLSQTTLALIDALTEYTKAVYTLISLQKQYANLLGKMNPEEEDAIWQVIIGAR 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083035   88 AEMTSKHQEYLKLETTWMTAVGLSEMAAEAAYQTGADQASITARNHIQLVKLQVEEVHQLSRKAETKLAEAQIEELRQKT 167
Cdd:pfam09057 124 VEMTDKQQEYLRFESNWMTAVNLSEMAAEAAYQSGADQASVTARTHIQVAQSQVEEVRQLSQEAETKLAEVQTEEIRRTQ 203
                         170       180
                  ....*....|....*....|....*...
gi 508083035  168 ---------QEEGEERAESEQEAYLRED 186
Cdd:pfam09057 204 ergesasepQGVELSEEEDIPEAYLRED 231
 
Name Accession Description Interval E-value
Smac_DIABLO pfam09057
Second Mitochondria-derived Activator of Caspases; Second Mitochondria-derived Activator of ...
8-186 2.10e-97

Second Mitochondria-derived Activator of Caspases; Second Mitochondria-derived Activator of Caspases promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway, and by opposing the inhibitory activity of inhibitor of apoptosis proteins (XIAP-BIR3). The protein assumes an elongated three-helix bundle structure, and forms a dimer in solution.


Pssm-ID: 462664  Cd Length: 231  Bit Score: 281.73  E-value: 2.10e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083035    8 QKSEPhSLSSEALMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLTSLYRQYTSLLGKMNSEEEDEVWQVIIGAR 87
Cdd:pfam09057  45 QKSEP-SLSHEALIRRAVSLVTDSANTFLSQTTLALIDALTEYTKAVYTLISLQKQYANLLGKMNPEEEDAIWQVIIGAR 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083035   88 AEMTSKHQEYLKLETTWMTAVGLSEMAAEAAYQTGADQASITARNHIQLVKLQVEEVHQLSRKAETKLAEAQIEELRQKT 167
Cdd:pfam09057 124 VEMTDKQQEYLRFESNWMTAVNLSEMAAEAAYQSGADQASVTARTHIQVAQSQVEEVRQLSQEAETKLAEVQTEEIRRTQ 203
                         170       180
                  ....*....|....*....|....*...
gi 508083035  168 ---------QEEGEERAESEQEAYLRED 186
Cdd:pfam09057 204 ergesasepQGVELSEEEDIPEAYLRED 231
 
Name Accession Description Interval E-value
Smac_DIABLO pfam09057
Second Mitochondria-derived Activator of Caspases; Second Mitochondria-derived Activator of ...
8-186 2.10e-97

Second Mitochondria-derived Activator of Caspases; Second Mitochondria-derived Activator of Caspases promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway, and by opposing the inhibitory activity of inhibitor of apoptosis proteins (XIAP-BIR3). The protein assumes an elongated three-helix bundle structure, and forms a dimer in solution.


Pssm-ID: 462664  Cd Length: 231  Bit Score: 281.73  E-value: 2.10e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083035    8 QKSEPhSLSSEALMRRAVSLVTDSTSTFLSQTTYALIEAITEYTKAVYTLTSLYRQYTSLLGKMNSEEEDEVWQVIIGAR 87
Cdd:pfam09057  45 QKSEP-SLSHEALIRRAVSLVTDSANTFLSQTTLALIDALTEYTKAVYTLISLQKQYANLLGKMNPEEEDAIWQVIIGAR 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 508083035   88 AEMTSKHQEYLKLETTWMTAVGLSEMAAEAAYQTGADQASITARNHIQLVKLQVEEVHQLSRKAETKLAEAQIEELRQKT 167
Cdd:pfam09057 124 VEMTDKQQEYLRFESNWMTAVNLSEMAAEAAYQSGADQASVTARTHIQVAQSQVEEVRQLSQEAETKLAEVQTEEIRRTQ 203
                         170       180
                  ....*....|....*....|....*...
gi 508083035  168 ---------QEEGEERAESEQEAYLRED 186
Cdd:pfam09057 204 ergesasepQGVELSEEEDIPEAYLRED 231
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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