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Conserved domains on  [gi|526118147|ref|NP_001267717|]
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surfeit locus protein 4 isoform 2 [Homo sapiens]

Protein Classification

surfeit locus protein 4( domain architecture ID 10489137)

surfeit locus protein 4 (SURF4) acts as an endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion

Gene Ontology:  GO:0016020|GO:0038024

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SURF4 pfam02077
SURF4 family;
2-254 2.86e-132

SURF4 family;


:

Pssm-ID: 111019  Cd Length: 267  Bit Score: 374.04  E-value: 2.86e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526118147    2 FLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFG 81
Cdd:pfam02077  14 FARKTKPYLPTLARLCLVATFFEDGIRMLFQWSDQVNYMDYSWGCGYFFATVFVIVNLVGQLIGSLLVMLRKKVTYACGV 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526118147   82 LFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRES-SPKQYMQLGGRVLLVLMFMTLLHF 160
Cdd:pfam02077  94 LFFIVILQTIAYGLLTDLKFLLRNISVIGGLLLLLAESRIEKKSLFAGLPTMGEEnKPKSYMLLAGRVLLVLMFISLLHF 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526118147  161 DASFFSIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVAL 240
Cdd:pfam02077 174 EMSWTRILLCIIGTALMILVAIGFKTKLAAIMLVLWLFAYNIYLNAFWTIPSDKPLRDFLKYDFFQTLSVIGGLLLVVNT 253
                         250
                  ....*....|....
gi 526118147  241 GPGGVSMDEKKKEW 254
Cdd:pfam02077 254 GPGGVSVDEKKKIW 267
 
Name Accession Description Interval E-value
SURF4 pfam02077
SURF4 family;
2-254 2.86e-132

SURF4 family;


Pssm-ID: 111019  Cd Length: 267  Bit Score: 374.04  E-value: 2.86e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526118147    2 FLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFG 81
Cdd:pfam02077  14 FARKTKPYLPTLARLCLVATFFEDGIRMLFQWSDQVNYMDYSWGCGYFFATVFVIVNLVGQLIGSLLVMLRKKVTYACGV 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526118147   82 LFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRES-SPKQYMQLGGRVLLVLMFMTLLHF 160
Cdd:pfam02077  94 LFFIVILQTIAYGLLTDLKFLLRNISVIGGLLLLLAESRIEKKSLFAGLPTMGEEnKPKSYMLLAGRVLLVLMFISLLHF 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526118147  161 DASFFSIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVAL 240
Cdd:pfam02077 174 EMSWTRILLCIIGTALMILVAIGFKTKLAAIMLVLWLFAYNIYLNAFWTIPSDKPLRDFLKYDFFQTLSVIGGLLLVVNT 253
                         250
                  ....*....|....
gi 526118147  241 GPGGVSMDEKKKEW 254
Cdd:pfam02077 254 GPGGVSVDEKKKIW 267
 
Name Accession Description Interval E-value
SURF4 pfam02077
SURF4 family;
2-254 2.86e-132

SURF4 family;


Pssm-ID: 111019  Cd Length: 267  Bit Score: 374.04  E-value: 2.86e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526118147    2 FLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFG 81
Cdd:pfam02077  14 FARKTKPYLPTLARLCLVATFFEDGIRMLFQWSDQVNYMDYSWGCGYFFATVFVIVNLVGQLIGSLLVMLRKKVTYACGV 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526118147   82 LFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRES-SPKQYMQLGGRVLLVLMFMTLLHF 160
Cdd:pfam02077  94 LFFIVILQTIAYGLLTDLKFLLRNISVIGGLLLLLAESRIEKKSLFAGLPTMGEEnKPKSYMLLAGRVLLVLMFISLLHF 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 526118147  161 DASFFSIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVAL 240
Cdd:pfam02077 174 EMSWTRILLCIIGTALMILVAIGFKTKLAAIMLVLWLFAYNIYLNAFWTIPSDKPLRDFLKYDFFQTLSVIGGLLLVVNT 253
                         250
                  ....*....|....
gi 526118147  241 GPGGVSMDEKKKEW 254
Cdd:pfam02077 254 GPGGVSVDEKKKIW 267
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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