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Conserved domains on  [gi|531034776|ref|NP_001269075|]
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neuroligin-4, X-linked [Homo sapiens]

Protein Classification

carboxylesterase/lipase family protein( domain architecture ID 10444481)

carboxylesterase/lipase family protein similar to carboxylesterase, which catalyzes the hydrolysis of a carboxylic ester to form an alcohol and a carboxylate, and lipase, which hydrolyzes triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
44-590 0e+00

Carboxylesterase family;


:

Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 729.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776   44 QYPVVNTNYGKIRGLRTPLPNEilGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDM 123
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGG--KPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTSPGSSG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  124 LPiwftanldtlmtyvqdQNEDCLYLNIYVPTEDdiHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINY 203
Cdd:pfam00135  79 LE----------------GSEDCLYLNVYTPKEL--KENKNKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINY 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  204 RLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTA 283
Cdd:pfam00135 141 RLGPLGFLSTGDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSA 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  284 LSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELI----QQTITPATYHIAFGPVIDGDVIPDDPQILMEQ 359
Cdd:pfam00135 221 LSPWAIQSNARQRAKELAKLVGCPTSDSAELVECLRSKPAEELLdaqlKLLVYGSVPFVPFGPVVDGDFLPEHPEELLKS 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  360 GEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEG-KDTLRETIKFMYTDWADKENPETRRK 438
Cdd:pfam00135 301 GNFPKVPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLVDlPEEISAALREEYLDWGDRDDPETSRR 380
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  439 TLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTelfscNFSKNDVM 518
Cdd:pfam00135 381 ALVELLTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSLRYPKWVGVDHGDELPYVFGTPFVGAL-----LFTEEDEK 455
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 531034776  519 LSAVVMTYWTNFAKTGDPNQPvpqdtkfihtkpnrFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFW 590
Cdd:pfam00135 456 LSRKMMTYWTNFAKTGNPNGP--------------EGLPKWPPYTDENGQYLSIDLEPRVKQGLKAERCAFW 513
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
44-590 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 729.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776   44 QYPVVNTNYGKIRGLRTPLPNEilGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDM 123
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGG--KPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTSPGSSG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  124 LPiwftanldtlmtyvqdQNEDCLYLNIYVPTEDdiHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINY 203
Cdd:pfam00135  79 LE----------------GSEDCLYLNVYTPKEL--KENKNKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINY 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  204 RLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTA 283
Cdd:pfam00135 141 RLGPLGFLSTGDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSA 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  284 LSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELI----QQTITPATYHIAFGPVIDGDVIPDDPQILMEQ 359
Cdd:pfam00135 221 LSPWAIQSNARQRAKELAKLVGCPTSDSAELVECLRSKPAEELLdaqlKLLVYGSVPFVPFGPVVDGDFLPEHPEELLKS 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  360 GEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEG-KDTLRETIKFMYTDWADKENPETRRK 438
Cdd:pfam00135 301 GNFPKVPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLVDlPEEISAALREEYLDWGDRDDPETSRR 380
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  439 TLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTelfscNFSKNDVM 518
Cdd:pfam00135 381 ALVELLTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSLRYPKWVGVDHGDELPYVFGTPFVGAL-----LFTEEDEK 455
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 531034776  519 LSAVVMTYWTNFAKTGDPNQPvpqdtkfihtkpnrFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFW 590
Cdd:pfam00135 456 LSRKMMTYWTNFAKTGNPNGP--------------EGLPKWPPYTDENGQYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
47-576 1.65e-144

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 434.84  E-value: 1.65e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  47 VVNTNYGKIRGLRTplpneilGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLhdmlpi 126
Cdd:cd00312    1 LVVTPNGKVRGVDE-------GGVYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGGL------ 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 127 wFTANLDtlmtyvqdQNEDCLYLNIYVPTEDDihdQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYG-NVIVITINYRL 205
Cdd:cd00312   68 -WNAKLP--------GSEDCLYLNVYTPKNTK---PGNSLPVMVWIHGGGFMFGSGSLYPGDGLAREGdNVIVVSINYRL 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 206 GILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALS 285
Cdd:cd00312  136 GVLGFLSTGDIELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALS 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 286 SWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQQT----ITPATYHIAFGPVIDGDVIPDDPQILMEQGE 361
Cdd:cd00312  216 PWAIQENARGRAKRLARLLGCNDTSSAELLDCLRSKSAEELLDATrkllLFSYSPFLPFGPVVDGDFIPDDPEELIKEGK 295
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 362 FLNYDIMLGVNQGEGLKFV--DGIVDNEDGVTPNDFDFSVsnFVDNLYGYPEGkdtLRETIKFMYTDWADkeNPETRRKT 439
Cdd:cd00312  296 FAKVPLIIGVTKDEGGYFAamLLNFDAKLIIETNDRWLEL--LPYLLFYADDA---LADKVLEKYPGDVD--DSVESRKN 368
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 440 LVALFTDHQWVAPAVATADLHAQY-GSPTYFYAFYHHCQ--SEMKPSWADSAHGDEVPYVFGIPmigpteLFSCNFSKND 516
Cdd:cd00312  369 LSDMLTDLLFKCPARYFLAQHRKAgGSPVYAYVFDHRSSlsVGRWPPWLGTVHGDEIFFVFGNP------LLKEGLREEE 442
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 517 VMLSAVVMTYWTNFAKTGDPNQPvpqdtkfihtkpnrFEEVAWSKYNPKDQLYLHIGLKP 576
Cdd:cd00312  443 EKLSRTMMKYWANFAKTGNPNTE--------------GNLVVWPAYTSESEKYLDINIEG 488
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
35-594 2.22e-144

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 434.70  E-value: 2.22e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  35 KFTLIDSQAQYPVVNTNYGKIRGLRTplpneilGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHL 114
Cdd:COG2272    2 KRLLAAAAAAAPVVRTEAGRVRGVVE-------GGVRVFLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPP 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 115 DERSllhdmlpiwftanldtlMTYVQDQNEDCLYLNIYVPTEDDihdqNSKKPVMVYIHGGSYMEGTGN--MIDGSILAS 192
Cdd:COG2272   75 RPGD-----------------PGGPAPGSEDCLYLNVWTPALAA----GAKLPVMVWIHGGGFVSGSGSepLYDGAALAR 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 193 YGnVIVITINYRLGILGF-----LSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSH 267
Cdd:COG2272  134 RG-VVVVTINYRLGALGFlalpaLSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASP 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 268 YSEGLFQKAIIQSGTALSSWAVNyQPAKYTRILADKVGCnmldTTDMVECLRNKNYKELI---QQTITPATYHIAFGPVI 344
Cdd:COG2272  213 LAKGLFHRAIAQSGAGLSVLTLA-EAEAVGAAFAAALGV----APATLAALRALPAEELLaaqAALAAEGPGGLPFGPVV 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 345 DGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVdGIVDNEDGVTPNDFDFSVSNfvdnlyGYPEGKDTLRETikfmY 424
Cdd:COG2272  288 DGDVLPEDPLEAFAAGRAADVPLLIGTNRDEGRLFA-ALLGDLGPLTAADYRAALRR------RFGDDADEVLAA----Y 356
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 425 tdwadkeNPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHcQSEMKPSWADSAHGDEVPYVFGIPMIGP 504
Cdd:COG2272  357 -------PAASPAEALAALATDRVFRCPARRLAEAHAAAGAPVYLYRFDWR-SPPLRGFGLGAFHGAELPFVFGNLDAPA 428
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 505 TElfscNFSKNDVMLSAVVMTYWTNFAKTGDPNQPvpqdtkfihtkpnrfEEVAWSKYNPKDQLYLHIGLKPRV-RDHYR 583
Cdd:COG2272  429 LT----GLTPADRALSDQMQAYWVNFARTGDPNGP---------------GLPEWPAYDPEDRAVMVFDAEPRVvNDPDA 489
                        570
                 ....*....|.
gi 531034776 584 ATKVAFWLELV 594
Cdd:COG2272  490 EERLDLWDGVV 500
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
44-590 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 729.88  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776   44 QYPVVNTNYGKIRGLRTPLPNEilGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLHDM 123
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGG--KPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTSPGSSG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  124 LPiwftanldtlmtyvqdQNEDCLYLNIYVPTEDdiHDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVITINY 203
Cdd:pfam00135  79 LE----------------GSEDCLYLNVYTPKEL--KENKNKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINY 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  204 RLGILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTA 283
Cdd:pfam00135 141 RLGPLGFLSTGDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSA 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  284 LSSWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELI----QQTITPATYHIAFGPVIDGDVIPDDPQILMEQ 359
Cdd:pfam00135 221 LSPWAIQSNARQRAKELAKLVGCPTSDSAELVECLRSKPAEELLdaqlKLLVYGSVPFVPFGPVVDGDFLPEHPEELLKS 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  360 GEFLNYDIMLGVNQGEGLKFVDGIVDNEDGVTPNDFDFSVSNFVDNLYGYPEG-KDTLRETIKFMYTDWADKENPETRRK 438
Cdd:pfam00135 301 GNFPKVPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLYLLLVDlPEEISAALREEYLDWGDRDDPETSRR 380
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  439 TLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWADSAHGDEVPYVFGIPMIGPTelfscNFSKNDVM 518
Cdd:pfam00135 381 ALVELLTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSLRYPKWVGVDHGDELPYVFGTPFVGAL-----LFTEEDEK 455
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 531034776  519 LSAVVMTYWTNFAKTGDPNQPvpqdtkfihtkpnrFEEVAWSKYNPKDQLYLHIGLKPRVRDHYRATKVAFW 590
Cdd:pfam00135 456 LSRKMMTYWTNFAKTGNPNGP--------------EGLPKWPPYTDENGQYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
47-576 1.65e-144

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 434.84  E-value: 1.65e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  47 VVNTNYGKIRGLRTplpneilGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHLDERSLLhdmlpi 126
Cdd:cd00312    1 LVVTPNGKVRGVDE-------GGVYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQWDQLGGGL------ 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 127 wFTANLDtlmtyvqdQNEDCLYLNIYVPTEDDihdQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYG-NVIVITINYRL 205
Cdd:cd00312   68 -WNAKLP--------GSEDCLYLNVYTPKNTK---PGNSLPVMVWIHGGGFMFGSGSLYPGDGLAREGdNVIVVSINYRL 135
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 206 GILGFLSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALS 285
Cdd:cd00312  136 GVLGFLSTGDIELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALS 215
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 286 SWAVNYQPAKYTRILADKVGCNMLDTTDMVECLRNKNYKELIQQT----ITPATYHIAFGPVIDGDVIPDDPQILMEQGE 361
Cdd:cd00312  216 PWAIQENARGRAKRLARLLGCNDTSSAELLDCLRSKSAEELLDATrkllLFSYSPFLPFGPVVDGDFIPDDPEELIKEGK 295
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 362 FLNYDIMLGVNQGEGLKFV--DGIVDNEDGVTPNDFDFSVsnFVDNLYGYPEGkdtLRETIKFMYTDWADkeNPETRRKT 439
Cdd:cd00312  296 FAKVPLIIGVTKDEGGYFAamLLNFDAKLIIETNDRWLEL--LPYLLFYADDA---LADKVLEKYPGDVD--DSVESRKN 368
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 440 LVALFTDHQWVAPAVATADLHAQY-GSPTYFYAFYHHCQ--SEMKPSWADSAHGDEVPYVFGIPmigpteLFSCNFSKND 516
Cdd:cd00312  369 LSDMLTDLLFKCPARYFLAQHRKAgGSPVYAYVFDHRSSlsVGRWPPWLGTVHGDEIFFVFGNP------LLKEGLREEE 442
                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 517 VMLSAVVMTYWTNFAKTGDPNQPvpqdtkfihtkpnrFEEVAWSKYNPKDQLYLHIGLKP 576
Cdd:cd00312  443 EKLSRTMMKYWANFAKTGNPNTE--------------GNLVVWPAYTSESEKYLDINIEG 488
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
35-594 2.22e-144

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 434.70  E-value: 2.22e-144
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  35 KFTLIDSQAQYPVVNTNYGKIRGLRTplpneilGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQHL 114
Cdd:COG2272    2 KRLLAAAAAAAPVVRTEAGRVRGVVE-------GGVRVFLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPP 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 115 DERSllhdmlpiwftanldtlMTYVQDQNEDCLYLNIYVPTEDDihdqNSKKPVMVYIHGGSYMEGTGN--MIDGSILAS 192
Cdd:COG2272   75 RPGD-----------------PGGPAPGSEDCLYLNVWTPALAA----GAKLPVMVWIHGGGFVSGSGSepLYDGAALAR 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 193 YGnVIVITINYRLGILGF-----LSTGDQAAKGNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSH 267
Cdd:COG2272  134 RG-VVVVTINYRLGALGFlalpaLSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASP 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 268 YSEGLFQKAIIQSGTALSSWAVNyQPAKYTRILADKVGCnmldTTDMVECLRNKNYKELI---QQTITPATYHIAFGPVI 344
Cdd:COG2272  213 LAKGLFHRAIAQSGAGLSVLTLA-EAEAVGAAFAAALGV----APATLAALRALPAEELLaaqAALAAEGPGGLPFGPVV 287
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 345 DGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVdGIVDNEDGVTPNDFDFSVSNfvdnlyGYPEGKDTLRETikfmY 424
Cdd:COG2272  288 DGDVLPEDPLEAFAAGRAADVPLLIGTNRDEGRLFA-ALLGDLGPLTAADYRAALRR------RFGDDADEVLAA----Y 356
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 425 tdwadkeNPETRRKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHcQSEMKPSWADSAHGDEVPYVFGIPMIGP 504
Cdd:COG2272  357 -------PAASPAEALAALATDRVFRCPARRLAEAHAAAGAPVYLYRFDWR-SPPLRGFGLGAFHGAELPFVFGNLDAPA 428
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 505 TElfscNFSKNDVMLSAVVMTYWTNFAKTGDPNQPvpqdtkfihtkpnrfEEVAWSKYNPKDQLYLHIGLKPRV-RDHYR 583
Cdd:COG2272  429 LT----GLTPADRALSDQMQAYWVNFARTGDPNGP---------------GLPEWPAYDPEDRAVMVFDAEPRVvNDPDA 489
                        570
                 ....*....|.
gi 531034776 584 ATKVAFWLELV 594
Cdd:COG2272  490 EERLDLWDGVV 500
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
151-257 4.68e-14

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 71.83  E-value: 4.68e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 151 IYVPTEDDihdqnSKKPVMVYIHGGSYMEGTGNMIDG--SILASYGNVIVITINYRLgilgflstgdqAAKGNY--GLLD 226
Cdd:COG0657    3 VYRPAGAK-----GPLPVVVYFHGGGWVSGSKDTHDPlaRRLAARAGAAVVSVDYRL-----------APEHPFpaALED 66
                         90       100       110
                 ....*....|....*....|....*....|.
gi 531034776 227 QIQALRWIEENVGAFGGDPKRVTIFGSGAGA 257
Cdd:COG0657   67 AYAALRWLRANAAELGIDPDRIAVAGDSAGG 97
Abhydrolase_3 pfam07859
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
169-257 5.47e-10

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 400284 [Multi-domain]  Cd Length: 208  Bit Score: 59.92  E-value: 5.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  169 MVYIHGGSYMEGTGNMIDG--SILASYGNVIVITINYRLgilgflstgdqAAKGNY--GLLDQIQALRWIEENVGAFGGD 244
Cdd:pfam07859   1 LVYFHGGGFVLGSADTHDRlcRRLAAEAGAVVVSVDYRL-----------APEHPFpaAYDDAYAALRWLAEQAAELGAD 69
                          90
                  ....*....|...
gi 531034776  245 PKRVTIFGSGAGA 257
Cdd:pfam07859  70 PSRIAVAGDSAGG 82
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
149-266 1.42e-08

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 56.03  E-value: 1.42e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776  149 LNIYVPTEDDihdqnSKKPVMVYIHGGSYMEGT--------GNMIDGSILASYgnvIVITINYRLgilgflSTgdQAakg 220
Cdd:pfam20434   1 LDIYLPKNAK-----GPYPVVIWIHGGGWNSGDkeadmgfmTNTVKALLKAGY---AVASINYRL------ST--DA--- 61
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 531034776  221 nyGLLDQIQ----ALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLS 266
Cdd:pfam20434  62 --KFPAQIQdvkaAIRFLRANAAKYGIDTNKIALMGFSAGGHLALLAGLS 109
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
151-288 1.91e-07

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 52.71  E-value: 1.91e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 151 IYVPteddihDQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYGnVIVITINYRlgilGF-LSTGDQaakGNYGLLDQIQ 229
Cdd:COG1506   14 LYLP------ADGKKYPVVVYVHGGPGSRDDSFLPLAQALASRG-YAVLAPDYR----GYgESAGDW---GGDEVDDVLA 79
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 531034776 230 ALRWIEENVGAfggDPKRVTIFG-SGAGAscVSLLTLSHYSEgLFQKAIIQSGtaLSSWA 288
Cdd:COG1506   80 AIDYLAARPYV---DPDRIGIYGhSYGGY--MALLAAARHPD-RFKAAVALAG--VSDLR 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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