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Conserved domains on  [gi|537544585|ref|NP_001269288|]
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zinc finger protein 107 isoform b [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 8.20e-32

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 117.69  E-value: 8.20e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 537544585     4 LTFKDVAIEFSLEEWQCLDTAQRDLYRNVLLENYRNLVFLGIAVSKPYLITCLEQKKEPWN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
507-819 3.54e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 3.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 507 KPYKCEECDRAFSQSSNLTEHKKIHTGEKPYKC--EECGKAFNRFSTLTKHKRIHTGEKPYKCEECGKAFNQ--SYQLTR 582
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSkaSSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 583 HKIVHTKEKLNkceEFGKAFKQSSHRTIHKIIHTGEKPYKCEEHGKVFNQSSNLTTQKIIHTGENLYKFEEHGKAFNLFS 662
Cdd:COG5048  112 SSSSNSNDNNL---LSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 663 NITNHkiiyTGEKPHKCEECGKAYNRFSNLTIHKRIHTGEKPYQCAECGKAFNCSSTLNRHKIIHTGEKPYKCKECGKAF 742
Cdd:COG5048  189 SSNVS----TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 743 NLSSTLTAHKKIHTGE-------KPYKCEECGKAFNQSSNLTTHK--KIHTSE--KPYKCEE--CGKSFNQFSSLNIHKI 809
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330
                 ....*....|
gi 537544585 810 IHTGEKPYKC 819
Cdd:COG5048  345 LHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-577 2.06e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.03  E-value: 2.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 199 NSYKCEECGKAFNWFSTLTKHKRIHTGEKPYKC--EECGKAFNQSSQLTRHKIIHTEEKPNKCEECGKAFKQA------- 269
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 270 -----------------SHLTIHKIIHTGEKPYKYEECGKVFSQSSHLTTQKILHTGENLYKCKECGKAFNLFSNLTNHK 332
Cdd:COG5048  112 ssssnsndnnllsshslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 333 RIHAGEKPYKCKECGRA--FNISSNLNKQEKIHTGGKLNKC-EECDKAFNRSLKLTAHKKILMEEKPykceECGKVFNQF 409
Cdd:COG5048  192 VSTSIPSSSENSPLSSSysIPSSSSDQNLENSSSSLPLTTNsQLSPKSLLSQSPSSLSSSDSSSSAS----ESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 410 STLTRHKIIHTGE-------KPYKCKECGKAFNQSSNLTEHK--KIHTAE--KSYKCEE--CGKAFNQHSNLINHRKIYS 476
Cdd:COG5048  268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 477 GEKPYKC--EECGKAFNRSST-----LTRHKKIHTGEKPYKCE--ECDRAFSQSSNLTEHKKIHTGEKP--YKCEECGKA 545
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                        410       420       430
                 ....*....|....*....|....*....|..
gi 537544585 546 FNRFSTLTKHKRIHTGEKPYKCEECGKAFNQS 577
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 8.20e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 117.69  E-value: 8.20e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 537544585     4 LTFKDVAIEFSLEEWQCLDTAQRDLYRNVLLENYRNLVFLGIAVSKPYLITCLEQKKEPWN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.45e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.91  E-value: 1.45e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 537544585    3 PLTFKDVAIEFSLEEWQCLDTAQRDLYRNVLLENYRNLVFLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 2.09e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.83  E-value: 2.09e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 537544585   4 LTFKDVAIEFSLEEWQCLDTAQRDLYRNVLLENYRNLVFL 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
507-819 3.54e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 3.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 507 KPYKCEECDRAFSQSSNLTEHKKIHTGEKPYKC--EECGKAFNRFSTLTKHKRIHTGEKPYKCEECGKAFNQ--SYQLTR 582
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSkaSSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 583 HKIVHTKEKLNkceEFGKAFKQSSHRTIHKIIHTGEKPYKCEEHGKVFNQSSNLTTQKIIHTGENLYKFEEHGKAFNLFS 662
Cdd:COG5048  112 SSSSNSNDNNL---LSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 663 NITNHkiiyTGEKPHKCEECGKAYNRFSNLTIHKRIHTGEKPYQCAECGKAFNCSSTLNRHKIIHTGEKPYKCKECGKAF 742
Cdd:COG5048  189 SSNVS----TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 743 NLSSTLTAHKKIHTGE-------KPYKCEECGKAFNQSSNLTTHK--KIHTSE--KPYKCEE--CGKSFNQFSSLNIHKI 809
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330
                 ....*....|
gi 537544585 810 IHTGEKPYKC 819
Cdd:COG5048  345 LHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-577 2.06e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.03  E-value: 2.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 199 NSYKCEECGKAFNWFSTLTKHKRIHTGEKPYKC--EECGKAFNQSSQLTRHKIIHTEEKPNKCEECGKAFKQA------- 269
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 270 -----------------SHLTIHKIIHTGEKPYKYEECGKVFSQSSHLTTQKILHTGENLYKCKECGKAFNLFSNLTNHK 332
Cdd:COG5048  112 ssssnsndnnllsshslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 333 RIHAGEKPYKCKECGRA--FNISSNLNKQEKIHTGGKLNKC-EECDKAFNRSLKLTAHKKILMEEKPykceECGKVFNQF 409
Cdd:COG5048  192 VSTSIPSSSENSPLSSSysIPSSSSDQNLENSSSSLPLTTNsQLSPKSLLSQSPSSLSSSDSSSSAS----ESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 410 STLTRHKIIHTGE-------KPYKCKECGKAFNQSSNLTEHK--KIHTAE--KSYKCEE--CGKAFNQHSNLINHRKIYS 476
Cdd:COG5048  268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 477 GEKPYKC--EECGKAFNRSST-----LTRHKKIHTGEKPYKCE--ECDRAFSQSSNLTEHKKIHTGEKP--YKCEECGKA 545
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                        410       420       430
                 ....*....|....*....|....*....|..
gi 537544585 546 FNRFSTLTKHKRIHTGEKPYKCEECGKAFNQS 577
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
zf-H2C2_2 pfam13465
Zinc-finger double domain;
523-548 2.53e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.53e-04
                          10        20
                  ....*....|....*....|....*.
gi 537544585  523 NLTEHKKIHTGEKPYKCEECGKAFNR 548
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
216-240 3.71e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.71e-04
                          10        20
                  ....*....|....*....|....*
gi 537544585  216 LTKHKRIHTGEKPYKCEECGKAFNQ 240
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-64 8.20e-32

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 117.69  E-value: 8.20e-32
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 537544585     4 LTFKDVAIEFSLEEWQCLDTAQRDLYRNVLLENYRNLVFLGIAVSKPYLITCLEQKKEPWN 64
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.45e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.91  E-value: 1.45e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 537544585    3 PLTFKDVAIEFSLEEWQCLDTAQRDLYRNVLLENYRNLVFLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 2.09e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 81.83  E-value: 2.09e-19
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 537544585   4 LTFKDVAIEFSLEEWQCLDTAQRDLYRNVLLENYRNLVFL 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
507-819 3.54e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 3.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 507 KPYKCEECDRAFSQSSNLTEHKKIHTGEKPYKC--EECGKAFNRFSTLTKHKRIHTGEKPYKCEECGKAFNQ--SYQLTR 582
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSkaSSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 583 HKIVHTKEKLNkceEFGKAFKQSSHRTIHKIIHTGEKPYKCEEHGKVFNQSSNLTTQKIIHTGENLYKFEEHGKAFNLFS 662
Cdd:COG5048  112 SSSSNSNDNNL---LSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 663 NITNHkiiyTGEKPHKCEECGKAYNRFSNLTIHKRIHTGEKPYQCAECGKAFNCSSTLNRHKIIHTGEKPYKCKECGKAF 742
Cdd:COG5048  189 SSNVS----TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 743 NLSSTLTAHKKIHTGE-------KPYKCEECGKAFNQSSNLTTHK--KIHTSE--KPYKCEE--CGKSFNQFSSLNIHKI 809
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330
                 ....*....|
gi 537544585 810 IHTGEKPYKC 819
Cdd:COG5048  345 LHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
255-724 1.18e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.27  E-value: 1.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 255 KPNKCEECGKAFKQASHLTIHKIIHTGEKPY--KYEECGKVFSQSSHLTTQKILHTGENLYKC-KECGKAFNLFSNLTNH 331
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSqcSYSGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 332 KRIHAGEKPYKCKECGrafnISSNLNKQEKIHTGGKLNKCEECDKAFNRSLKltAHKKILMEEKPYKCEECGKVFNQFST 411
Cdd:COG5048  112 SSSSNSNDNNLLSSHS----LPPSSRDPQLPDLLSISNLRNNPLPGNNSSSV--NTPQSNSLHPPLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 412 LTRHKIIHTGEKPYKCKECGKAFNQSSNLTEHKKIHTAEKSYKCEECGKAFNQHSNLINHRKIYSGEKPYKCEECGKAFN 491
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 492 RSSTLTRHKKIHTGE-------KPYKCEECDRAFSQSSNLTEHK--KIHTGE--KPYKCEE--CGKAFNRFSTLTKHKRI 558
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 559 HTGEKPYKCeecgkafnqsyqltrhKIVHTKEKLNKCEEfGKAFKQSSHRTIHKIIHTGEKPYKCEEhgKVFNQSSNLTT 638
Cdd:COG5048  346 HTSISPAKE----------------KLLNSSSKFSPLLN-NEPPQSLQQYKDLKNDKKSETLSNSCI--RNFKRDSNLSL 406

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 639 QKIIHTGENLYKFeehgkafnlfsnitnhkiiytgekphKCEECGKAYNRFSNLTIHKRIHTGEKPYQCAECGKAFNCSS 718
Cdd:COG5048  407 HIITHLSFRPYNC--------------------------KNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460


                 ....*.
gi 537544585 719 TLNRHK 724
Cdd:COG5048  461 LSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
380-830 2.39e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 2.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 380 RSLKLTAHKKILMEEKPYKCEECGKVFNQFSTLTRHKIIHTGEKPYKC--KECGKAFNQSSNLTEHKKIHTAEKSYKCE- 456
Cdd:COG5048   17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSk 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 457 ECGKAFNQHSNLINHRKIYSGEKPYKCEECGKAFNRSSTLTRHKKIHTGEKPYKCEECDRAFSQSSNLTEHKKIHTGEkp 536
Cdd:COG5048   97 SLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-- 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 537 ykcEECGKAFNRFSTLTKHKRIHTGEKPYKCEECgkafNQSYQLTRHKIVHTKEklnkceefgkafKQSSHRTIHKIIHT 616
Cdd:COG5048  175 ---SLSKDPSSNLSLLISSNVSTSIPSSSENSPL----SSSYSIPSSSSDQNLE------------NSSSSLPLTTNSQL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 617 GEKPYKCEEHGKVFNQSSNLTTQKiihTGENLYKFEEHGKAFNLFSNITNHKIIYTgekPHKCEECGKAYNRFSNLTIHK 696
Cdd:COG5048  236 SPKSLLSQSPSSLSSSDSSSSASE---SPRSSLPTASSQSSSPNESDSSSEKGFSL---PIKSKQCNISFSRSSPLTRHL 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 697 R--IHTGE--KPYQCAE--CGKAFNCSSTLNRHKIIHTGEKPYKCKEC-------GKAFNLSSTLTAHKKIHTGEKPYKC 763
Cdd:COG5048  310 RsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSET 389

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 537544585 764 E--ECGKAFNQSSNLTTHKKIHTSEKP--YKCEECGKSFNQFSSLNIHKIIHTGEKPYKCGDYGRAFNLSS 830
Cdd:COG5048  390 LsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
199-577 2.06e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.03  E-value: 2.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 199 NSYKCEECGKAFNWFSTLTKHKRIHTGEKPYKC--EECGKAFNQSSQLTRHKIIHTEEKPNKCEECGKAFKQA------- 269
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKassssls 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 270 -----------------SHLTIHKIIHTGEKPYKYEECGKVFSQSSHLTTQKILHTGENLYKCKECGKAFNLFSNLTNHK 332
Cdd:COG5048  112 ssssnsndnnllsshslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 333 RIHAGEKPYKCKECGRA--FNISSNLNKQEKIHTGGKLNKC-EECDKAFNRSLKLTAHKKILMEEKPykceECGKVFNQF 409
Cdd:COG5048  192 VSTSIPSSSENSPLSSSysIPSSSSDQNLENSSSSLPLTTNsQLSPKSLLSQSPSSLSSSDSSSSAS----ESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 410 STLTRHKIIHTGE-------KPYKCKECGKAFNQSSNLTEHK--KIHTAE--KSYKCEE--CGKAFNQHSNLINHRKIYS 476
Cdd:COG5048  268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 477 GEKPYKC--EECGKAFNRSST-----LTRHKKIHTGEKPYKCE--ECDRAFSQSSNLTEHKKIHTGEKP--YKCEECGKA 545
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                        410       420       430
                 ....*....|....*....|....*....|..
gi 537544585 546 FNRFSTLTKHKRIHTGEKPYKCEECGKAFNQS 577
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAPLLCSILKSFRRDL 459
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
479-848 1.49e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 1.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 479 KPYKCEECGKAFNRSSTLTRHKKIHTGEKPYKC--EECDRAFSQSSNLTEHKKIHTGEKPYkcEECGKAFNRFSTLTKHK 556
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 557 RIHTGEKPYKCE-ECGKAFNQSYQLTRHKIVHTKEKLNKCEEFGKAFKQSSHRTIHKIIHTGEKPYKCEEHgkvFNQSSN 635
Cdd:COG5048  110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDP---SSNLSL 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 636 LTTQKIIHTGENLYKFEEHGKaFNLFSNITNHKIIYTGEKPHKCEECGKAYNRFSNLTIHKRIHTGEKPYQCAECGKAFN 715
Cdd:COG5048  187 LISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 716 CSSTLNRHKIIHTGE-------KPYKCKECGKAFNLSSTLTAHK--KIHTGE--KPYKCEE--CGKAFNQSSNLTTHKKI 782
Cdd:COG5048  266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 783 HTSEKPYKC--EECGKSFNQFS------SLNIHKIIHT-------------------------------GEKPYKCGDYG 823
Cdd:COG5048  346 HTSISPAKEklLNSSSKFSPLLnneppqSLQQYKDLKNdkksetlsnscirnfkrdsnlslhiithlsfRPYNCKNPPCS 425

                        410       420
                 ....*....|....*....|....*
gi 537544585 824 RAFNLSSNLTTHKKIHTGEKPYKCE 848
Cdd:COG5048  426 KSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
523-548 2.53e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.53e-04
                          10        20
                  ....*....|....*....|....*.
gi 537544585  523 NLTEHKKIHTGEKPYKCEECGKAFNR 548
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
552-576 3.71e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.71e-04
                          10        20
                  ....*....|....*....|....*
gi 537544585  552 LTKHKRIHTGEKPYKCEECGKAFNQ 576
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
216-240 3.71e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.71e-04
                          10        20
                  ....*....|....*....|....*
gi 537544585  216 LTKHKRIHTGEKPYKCEECGKAFNQ 240
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
412-436 4.98e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.98e-04
                          10        20
                  ....*....|....*....|....*
gi 537544585  412 LTRHKIIHTGEKPYKCKECGKAFNQ 436
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
720-743 5.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.77e-04
                          10        20
                  ....*....|....*....|....
gi 537544585  720 LNRHKIIHTGEKPYKCKECGKAFN 743
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
496-520 6.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 6.00e-04
                          10        20
                  ....*....|....*....|....*
gi 537544585  496 LTRHKKIHTGEKPYKCEECDRAFSQ 520
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
775-800 8.38e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.38e-04
                          10        20
                  ....*....|....*....|....*.
gi 537544585  775 NLTTHKKIHTSEKPYKCEECGKSFNQ 800
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
691-716 8.89e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.89e-04
                          10        20
                  ....*....|....*....|....*.
gi 537544585  691 NLTIHKRIHTGEKPYQCAECGKAFNC 716
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 421-501 1.52e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 421 GEKPYKCK--ECGKAFNQSSNLTEHKKiHTaeksykceECGKAFNQHSNLINHRKIYSGEKPYKCEECGKAFNRSSTLTR 498
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 537544585 499 HKK 501
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
748-772 1.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.77e-03
                          10        20
                  ....*....|....*....|....*
gi 537544585  748 LTAHKKIHTGEKPYKCEECGKAFNQ 772
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
773-851 1.92e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 773 SSNLTTHKKIHTSEKPYKCEECGKSFNQFSSLNIHKIIHTGEKPYKCGDYGRAFNLS--SNLTTHKKIHTGEKPYKCEYG 850
Cdd:COG5048   18 STPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDLNSKS 97


                 .
gi 537544585 851 K 851
Cdd:COG5048   98 L 98
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
171-335 2.16e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 2.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 171 KHFKCKECSKSFCVLSQLTQHRR--IHTRVNSYKCEE----CGKAFNWFSTLTKHKRIHTGEKPYKCEecgkafnqssqL 244
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLHTSISPAKEK-----------L 356

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 245 TRHKIIHTEEKPNkceecgkafKQASHLTIHKIIHTGEKPYK-YEECGKVFSQSSHLTTQKILHTGEN--LYKCKECGKA 321
Cdd:COG5048  357 LNSSSKFSPLLNN---------EPPQSLQQYKDLKNDKKSETlSNSCIRNFKRDSNLSLHIITHLSFRpyNCKNPPCSKS 427

                        170
                 ....*....|....
gi 537544585 322 FNLFSNLTNHKRIH 335
Cdd:COG5048  428 FNRHYNLIPHKKIH 441
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 505-584 2.23e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 505 GEKPYKCE--ECDRAFSQSSNLTEHKKiHTGEKPYKCEECGKafnrfstlTKHKRIHTGEKPYKCEECGKAFNQSYQLTR 582
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 537544585 583 HK 584
Cdd:COG5189  417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 757-808 2.32e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 2.32e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 537544585 757 GEKPYKCE--ECGKAFNQSSNLTTHKK-------------------IHTSEKPYKCEECGKSFNQFSSLNIHK 808
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 477-556 2.36e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 2.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 537544585 477 GEKPYKCE--ECGKAFNRSSTLTRHKKiHTGEKPYKCEECDRafsqssnlTEHKKIHTGEKPYKCEECGKAFNRFSTLTK 554
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 537544585 555 HK 556
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
439-464 4.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.49e-03
                          10        20
                  ....*....|....*....|....*.
gi 537544585  439 NLTEHKKIHTAEKSYKCEECGKAFNQ 464
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
327-351 6.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.72e-03
                          10        20
                  ....*....|....*....|....*
gi 537544585  327 NLTNHKRIHAGEKPYKCKECGRAFN 351
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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