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protein phosphatase 1 regulatory subunit 7 isoform 5 [Homo sapiens]
leucine-rich repeat domain-containing protein( domain architecture ID 1903219)
leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||
PPP1R42 super family | cl42388 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
147-338 | 2.93e-39 | ||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. The actual alignment was detected with superfamily member cd21340: Pssm-ID: 455733 [Multi-domain] Cd Length: 220 Bit Score: 138.38 E-value: 2.93e-39
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PPP1R42 super family | cl42388 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
67-182 | 9.40e-13 | ||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. The actual alignment was detected with superfamily member cd21340: Pssm-ID: 455733 [Multi-domain] Cd Length: 220 Bit Score: 66.73 E-value: 9.40e-13
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Name | Accession | Description | Interval | E-value | |||||
PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
147-338 | 2.93e-39 | |||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 138.38 E-value: 2.93e-39
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
79-296 | 3.26e-28 | |||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 113.49 E-value: 3.26e-28
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
67-182 | 9.40e-13 | |||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 66.73 E-value: 9.40e-13
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LRR_9 | pfam14580 | Leucine-rich repeat; |
107-228 | 1.11e-08 | |||||
Leucine-rich repeat; Pssm-ID: 405295 [Multi-domain] Cd Length: 175 Bit Score: 54.00 E-value: 1.11e-08
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
86-320 | 5.65e-05 | |||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 44.84 E-value: 5.65e-05
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LRR_4 | pfam12799 | Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
104-146 | 4.85e-04 | |||||
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 37.22 E-value: 4.85e-04
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LRRcap | smart00446 | occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ... |
320-338 | 4.54e-03 | |||||
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins. Pssm-ID: 197729 Cd Length: 19 Bit Score: 34.20 E-value: 4.54e-03
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Name | Accession | Description | Interval | E-value | |||||
PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
147-338 | 2.93e-39 | |||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 138.38 E-value: 2.93e-39
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
79-296 | 3.26e-28 | |||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 113.49 E-value: 3.26e-28
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
89-315 | 1.85e-25 | |||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 105.79 E-value: 1.85e-25
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
84-321 | 3.12e-20 | |||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 90.76 E-value: 3.12e-20
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
66-323 | 5.13e-18 | |||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 84.21 E-value: 5.13e-18
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
85-317 | 4.17e-16 | |||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 78.82 E-value: 4.17e-16
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
63-310 | 3.73e-14 | |||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 73.04 E-value: 3.73e-14
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
71-229 | 4.54e-14 | |||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 70.20 E-value: 4.54e-14
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
67-182 | 9.40e-13 | |||||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 66.73 E-value: 9.40e-13
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LRR_9 | pfam14580 | Leucine-rich repeat; |
107-228 | 1.11e-08 | |||||
Leucine-rich repeat; Pssm-ID: 405295 [Multi-domain] Cd Length: 175 Bit Score: 54.00 E-value: 1.11e-08
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RNA1 | COG5238 | Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ... |
53-324 | 1.14e-08 | |||||
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis]; Pssm-ID: 444072 [Multi-domain] Cd Length: 434 Bit Score: 56.34 E-value: 1.14e-08
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LRR_9 | pfam14580 | Leucine-rich repeat; |
175-338 | 1.68e-08 | |||||
Leucine-rich repeat; Pssm-ID: 405295 [Multi-domain] Cd Length: 175 Bit Score: 53.61 E-value: 1.68e-08
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
128-318 | 8.41e-08 | |||||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 53.40 E-value: 8.41e-08
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LRR_8 | pfam13855 | Leucine rich repeat; |
214-270 | 2.66e-05 | |||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 41.36 E-value: 2.66e-05
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PLN00113 | PLN00113 | leucine-rich repeat receptor-like protein kinase; Provisional |
86-320 | 5.65e-05 | |||||
leucine-rich repeat receptor-like protein kinase; Provisional Pssm-ID: 215061 [Multi-domain] Cd Length: 968 Bit Score: 44.84 E-value: 5.65e-05
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LRR_8 | pfam13855 | Leucine rich repeat; |
192-248 | 6.07e-05 | |||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 40.20 E-value: 6.07e-05
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LRR_4 | pfam12799 | Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
214-246 | 2.93e-04 | |||||
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 38.00 E-value: 2.93e-04
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LRR_8 | pfam13855 | Leucine rich repeat; |
126-182 | 3.29e-04 | |||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 38.27 E-value: 3.29e-04
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LRR_4 | pfam12799 | Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
104-146 | 4.85e-04 | |||||
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 37.22 E-value: 4.85e-04
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LRR_4 | pfam12799 | Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
192-234 | 4.94e-04 | |||||
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 37.22 E-value: 4.94e-04
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LRR_8 | pfam13855 | Leucine rich repeat; |
148-204 | 1.02e-03 | |||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 36.73 E-value: 1.02e-03
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LRR_9 | pfam14580 | Leucine-rich repeat; |
65-140 | 1.36e-03 | |||||
Leucine-rich repeat; Pssm-ID: 405295 [Multi-domain] Cd Length: 175 Bit Score: 38.98 E-value: 1.36e-03
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LRR_4 | pfam12799 | Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
148-193 | 1.53e-03 | |||||
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 36.07 E-value: 1.53e-03
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LRR_8 | pfam13855 | Leucine rich repeat; |
237-292 | 1.79e-03 | |||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 36.35 E-value: 1.79e-03
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LRR_4 | pfam12799 | Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
237-278 | 2.17e-03 | |||||
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 35.68 E-value: 2.17e-03
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LRR_4 | pfam12799 | Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
126-168 | 3.03e-03 | |||||
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 34.91 E-value: 3.03e-03
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LRRcap | smart00446 | occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ... |
320-338 | 4.54e-03 | |||||
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins. Pssm-ID: 197729 Cd Length: 19 Bit Score: 34.20 E-value: 4.54e-03
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LRR_8 | pfam13855 | Leucine rich repeat; |
104-160 | 6.07e-03 | |||||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 34.81 E-value: 6.07e-03
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LRR_4 | pfam12799 | Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
82-123 | 7.50e-03 | |||||
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 34.14 E-value: 7.50e-03
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Blast search parameters | ||||
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