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Conserved domains on  [gi|542133159|ref|NP_001269461|]
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activity-dependent neuroprotector homeobox protein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ADNP_N pfam19627
Activity-dependent neuroprotector homeobox protein N-terminal; This entry represent the ...
1-754 0e+00

Activity-dependent neuroprotector homeobox protein N-terminal; This entry represent the N-terminal domain of Activity-dependent neuroprotector homeobox protein (ADNP, also known as Activity- dependent neuroprotective protein), which contains zinc finger motifs. It is involved in transcriptional regulation and it is vital for mammalian brain formation. In humans, de novo mutations result in a syndromic form of autism-like spectrum disorder (ASD), including cognitive and motor deficits, the ADNP syndrome. This protein is also related to autophagy and the pathophysiology of schizophrenia.


:

Pssm-ID: 466132 [Multi-domain]  Cd Length: 744  Bit Score: 1502.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159     1 MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACP 80
Cdd:pfam19627    1 MFQLPVNNLGSLRKARKNVKKILSDIGLEYCKEHIEDFKDFEPNDFYIKNTSWDDVCLWDPSLTKNQDYRTKPFCCSGCP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159    81 FSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTFNADKKTLETHIKIFHAPNASA--PSSSLSTFKDKNKNDGLKPKQAD 158
Cdd:pfam19627   81 FSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTYNGNKKTLETHIKLFHMPNNVVrqPSGGPVGFKDKSKQDSLKPKQGD 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   159 SVEQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKAGEKSLNGAVPlGSNAREESSIHCKRCLFMPKSYEALVQ 238
Cdd:pfam19627  161 SVEQAVYYCKKCTYRDPLYNVVRKHIYREHFQHVAAPYVAKPGEKSVNGAVA-SSNTRDDGSIHCKRCLFMPRTYEALVQ 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   239 HVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLIAPKPQDKKSMGLPPRiGSLASGNVRSLPSQQMvNRLSIPkpnlnstG 318
Cdd:pfam19627  240 HVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLIAPKPQDKKSLGVTQK-GGLVTGNVRSLSSQQM-NRLSIP-------K 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   319 VNMMSSVHLQQNNYGVKSVGQGYSVGQSMRLGLGGNAPVSIPQQSQSVKQLLPSGNGRSYGLGSEQRSQAPARYSLQSAN 398
Cdd:pfam19627  311 ANLLSNVHLKQGSYGLKSMPSFYVLGQQVRLSLPGNAQVSVPQQSQTVKQLLPGGNGRPSTVGSSQSGQQPARFSVQSGN 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   399 ASSLSSGQLKSPSLSQSQ-ASRVLGQSSSKPAAAATGPppgNTSSTQKWKICTICNELFPENVYSVHFEKEHKAEKVPAV 477
Cdd:pfam19627  391 SASSSSSQLKSPPLSSSVaATRALGQGPSKSSASAAGL---NTSYTQKWKICTICNELFPENVYSAHFEKEHKAEKVPAV 467
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   478 ANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLIHGLSCPYCRSTFNDVEKMAAHMRMVHIDEEMGPKTDSTLSFDLTLQQG 557
Cdd:pfam19627  468 ANYIMKIHNFTSKCLYCNRYLPSDTLLNHMLIHGLSCPYCRSTFNDVEKMVAHMRMVHPDEEVGPRTDSPLTFDLTLQQG 547
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   558 SHTNIHLLVTTYNLRDAPAESVAYHAQNNPPVPPKPQPKVQEKADIPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISD 637
Cdd:pfam19627  548 NPKNIQLLVTTYNMRDAPEESVAFHAQNNSPQPKKPKPKVQEKSDVPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISD 627
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   638 ALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDKTNAPSRLNQSPSLAPVKR 717
Cdd:pfam19627  628 ALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDKSAPSPRVTQSPGAAPLKR 707
                          730       740       750
                   ....*....|....*....|....*....|....*..
gi 542133159   718 TYEQMEFPLLKKRKLDDDSDSPSFFEEKPEEPVVLAL 754
Cdd:pfam19627  708 ELEHVDPALPKKRKLDDEEDYPSAFVEKPEEPVVLAL 744
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
768-811 1.05e-10

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


:

Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 58.03  E-value: 1.05e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 542133159    768 KSFLTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKKC 811
Cdd:smart00389   13 LEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
 
Name Accession Description Interval E-value
ADNP_N pfam19627
Activity-dependent neuroprotector homeobox protein N-terminal; This entry represent the ...
1-754 0e+00

Activity-dependent neuroprotector homeobox protein N-terminal; This entry represent the N-terminal domain of Activity-dependent neuroprotector homeobox protein (ADNP, also known as Activity- dependent neuroprotective protein), which contains zinc finger motifs. It is involved in transcriptional regulation and it is vital for mammalian brain formation. In humans, de novo mutations result in a syndromic form of autism-like spectrum disorder (ASD), including cognitive and motor deficits, the ADNP syndrome. This protein is also related to autophagy and the pathophysiology of schizophrenia.


Pssm-ID: 466132 [Multi-domain]  Cd Length: 744  Bit Score: 1502.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159     1 MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACP 80
Cdd:pfam19627    1 MFQLPVNNLGSLRKARKNVKKILSDIGLEYCKEHIEDFKDFEPNDFYIKNTSWDDVCLWDPSLTKNQDYRTKPFCCSGCP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159    81 FSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTFNADKKTLETHIKIFHAPNASA--PSSSLSTFKDKNKNDGLKPKQAD 158
Cdd:pfam19627   81 FSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTYNGNKKTLETHIKLFHMPNNVVrqPSGGPVGFKDKSKQDSLKPKQGD 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   159 SVEQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKAGEKSLNGAVPlGSNAREESSIHCKRCLFMPKSYEALVQ 238
Cdd:pfam19627  161 SVEQAVYYCKKCTYRDPLYNVVRKHIYREHFQHVAAPYVAKPGEKSVNGAVA-SSNTRDDGSIHCKRCLFMPRTYEALVQ 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   239 HVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLIAPKPQDKKSMGLPPRiGSLASGNVRSLPSQQMvNRLSIPkpnlnstG 318
Cdd:pfam19627  240 HVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLIAPKPQDKKSLGVTQK-GGLVTGNVRSLSSQQM-NRLSIP-------K 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   319 VNMMSSVHLQQNNYGVKSVGQGYSVGQSMRLGLGGNAPVSIPQQSQSVKQLLPSGNGRSYGLGSEQRSQAPARYSLQSAN 398
Cdd:pfam19627  311 ANLLSNVHLKQGSYGLKSMPSFYVLGQQVRLSLPGNAQVSVPQQSQTVKQLLPGGNGRPSTVGSSQSGQQPARFSVQSGN 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   399 ASSLSSGQLKSPSLSQSQ-ASRVLGQSSSKPAAAATGPppgNTSSTQKWKICTICNELFPENVYSVHFEKEHKAEKVPAV 477
Cdd:pfam19627  391 SASSSSSQLKSPPLSSSVaATRALGQGPSKSSASAAGL---NTSYTQKWKICTICNELFPENVYSAHFEKEHKAEKVPAV 467
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   478 ANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLIHGLSCPYCRSTFNDVEKMAAHMRMVHIDEEMGPKTDSTLSFDLTLQQG 557
Cdd:pfam19627  468 ANYIMKIHNFTSKCLYCNRYLPSDTLLNHMLIHGLSCPYCRSTFNDVEKMVAHMRMVHPDEEVGPRTDSPLTFDLTLQQG 547
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   558 SHTNIHLLVTTYNLRDAPAESVAYHAQNNPPVPPKPQPKVQEKADIPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISD 637
Cdd:pfam19627  548 NPKNIQLLVTTYNMRDAPEESVAFHAQNNSPQPKKPKPKVQEKSDVPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISD 627
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   638 ALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDKTNAPSRLNQSPSLAPVKR 717
Cdd:pfam19627  628 ALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDKSAPSPRVTQSPGAAPLKR 707
                          730       740       750
                   ....*....|....*....|....*....|....*..
gi 542133159   718 TYEQMEFPLLKKRKLDDDSDSPSFFEEKPEEPVVLAL 754
Cdd:pfam19627  708 ELEHVDPALPKKRKLDDEEDYPSAFVEKPEEPVVLAL 744
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
768-811 1.05e-10

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 58.03  E-value: 1.05e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 542133159    768 KSFLTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKKC 811
Cdd:smart00389   13 LEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
768-813 7.37e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 55.71  E-value: 7.37e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 542133159  768 KSFLTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKKCVR 813
Cdd:cd00086    12 LEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
Homeodomain pfam00046
Homeodomain;
771-810 4.89e-05

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 42.10  E-value: 4.89e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 542133159   771 LTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKK 810
Cdd:pfam00046   15 LEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAK 54
 
Name Accession Description Interval E-value
ADNP_N pfam19627
Activity-dependent neuroprotector homeobox protein N-terminal; This entry represent the ...
1-754 0e+00

Activity-dependent neuroprotector homeobox protein N-terminal; This entry represent the N-terminal domain of Activity-dependent neuroprotector homeobox protein (ADNP, also known as Activity- dependent neuroprotective protein), which contains zinc finger motifs. It is involved in transcriptional regulation and it is vital for mammalian brain formation. In humans, de novo mutations result in a syndromic form of autism-like spectrum disorder (ASD), including cognitive and motor deficits, the ADNP syndrome. This protein is also related to autophagy and the pathophysiology of schizophrenia.


Pssm-ID: 466132 [Multi-domain]  Cd Length: 744  Bit Score: 1502.44  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159     1 MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEPNDFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSACP 80
Cdd:pfam19627    1 MFQLPVNNLGSLRKARKNVKKILSDIGLEYCKEHIEDFKDFEPNDFYIKNTSWDDVCLWDPSLTKNQDYRTKPFCCSGCP 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159    81 FSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTFNADKKTLETHIKIFHAPNASA--PSSSLSTFKDKNKNDGLKPKQAD 158
Cdd:pfam19627   81 FSSKFFSAYKSHFRNVHSEDFENRILLNCPYCTYNGNKKTLETHIKLFHMPNNVVrqPSGGPVGFKDKSKQDSLKPKQGD 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   159 SVEQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKAGEKSLNGAVPlGSNAREESSIHCKRCLFMPKSYEALVQ 238
Cdd:pfam19627  161 SVEQAVYYCKKCTYRDPLYNVVRKHIYREHFQHVAAPYVAKPGEKSVNGAVA-SSNTRDDGSIHCKRCLFMPRTYEALVQ 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   239 HVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLIAPKPQDKKSMGLPPRiGSLASGNVRSLPSQQMvNRLSIPkpnlnstG 318
Cdd:pfam19627  240 HVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLIAPKPQDKKSLGVTQK-GGLVTGNVRSLSSQQM-NRLSIP-------K 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   319 VNMMSSVHLQQNNYGVKSVGQGYSVGQSMRLGLGGNAPVSIPQQSQSVKQLLPSGNGRSYGLGSEQRSQAPARYSLQSAN 398
Cdd:pfam19627  311 ANLLSNVHLKQGSYGLKSMPSFYVLGQQVRLSLPGNAQVSVPQQSQTVKQLLPGGNGRPSTVGSSQSGQQPARFSVQSGN 390
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   399 ASSLSSGQLKSPSLSQSQ-ASRVLGQSSSKPAAAATGPppgNTSSTQKWKICTICNELFPENVYSVHFEKEHKAEKVPAV 477
Cdd:pfam19627  391 SASSSSSQLKSPPLSSSVaATRALGQGPSKSSASAAGL---NTSYTQKWKICTICNELFPENVYSAHFEKEHKAEKVPAV 467
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   478 ANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLIHGLSCPYCRSTFNDVEKMAAHMRMVHIDEEMGPKTDSTLSFDLTLQQG 557
Cdd:pfam19627  468 ANYIMKIHNFTSKCLYCNRYLPSDTLLNHMLIHGLSCPYCRSTFNDVEKMVAHMRMVHPDEEVGPRTDSPLTFDLTLQQG 547
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   558 SHTNIHLLVTTYNLRDAPAESVAYHAQNNPPVPPKPQPKVQEKADIPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISD 637
Cdd:pfam19627  548 NPKNIQLLVTTYNMRDAPEESVAFHAQNNSPQPKKPKPKVQEKSDVPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISD 627
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 542133159   638 ALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDKTNAPSRLNQSPSLAPVKR 717
Cdd:pfam19627  628 ALAHHLRERHQVIQTVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDKSAPSPRVTQSPGAAPLKR 707
                          730       740       750
                   ....*....|....*....|....*....|....*..
gi 542133159   718 TYEQMEFPLLKKRKLDDDSDSPSFFEEKPEEPVVLAL 754
Cdd:pfam19627  708 ELEHVDPALPKKRKLDDEEDYPSAFVEKPEEPVVLAL 744
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
768-811 1.05e-10

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 58.03  E-value: 1.05e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 542133159    768 KSFLTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKKC 811
Cdd:smart00389   13 LEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKW 56
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
768-813 7.37e-10

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 55.71  E-value: 7.37e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 542133159  768 KSFLTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKKCVR 813
Cdd:cd00086    12 LEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKR 57
Homeodomain pfam00046
Homeodomain;
771-810 4.89e-05

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 42.10  E-value: 4.89e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 542133159   771 LTKYFNKQPYPTRREIEKLAASLWLWKSDIASHFSNKRKK 810
Cdd:pfam00046   15 LEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAK 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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