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Conserved domains on  [gi|545746309|ref|NP_001271168|]
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store-operated calcium entry-associated regulatory factor isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SARAF super family cl26304
SOCE-associated regulatory factor of calcium homoeostasis; SARAF is as family of eukaryotic ...
 1-167 3.95e-25

SOCE-associated regulatory factor of calcium homoeostasis; SARAF is as family of eukaryotic proteins embedded in the ER. SARAF is SOCE-associated regulatory factor, where SOCE is store operated calcium entry. ie a mechanism governing calcium homoeostasis in the cell and the mitochondria. SOCE involves the enabling of Ca2+ release-activated Ca2+ (CRAC) channels. SARAF is a single pass ER membrane protein whose systolic-facing domain is responsible for activity and whose luminary-facing domain carries out a regulatory function in conjunction with another membrane protein STIM, an ER single pass membrane protein that detects changes in ER Ca2+ levels through its EF-hand, conserved Ca2+ binding domain. STIM is the major target for SARAF regulation, and thus SARAF negatively regulates the SOCE entry of calcium into cells protecting them from overfilling.


The actual alignment was detected with superfamily member pfam06682:

Pssm-ID: 461985  Cd Length: 322  Bit Score: 98.18  E-value: 3.95e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746309    1 MSGLITIVVLLGIAFVVYKLFLSDGQYSPPPYSEYPPF-----SHRYQRFTNSAGPPPPGFKSEFTGPQntghgatSGFG 75
Cdd:pfam06682 157 AGGLFWVAVLGVIAYIVYKAFLRSNRRYGPGGGRRGGGgggggGGGGGGDGNYNDPPPPYFKSGSSGSQ-------KPSS 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746309   76 SAFTGQQGYENSG-PGFWTGLGTGGILGYLFGSNRAATPFSDSWYYPSYPPSYPGTWNRAYSPLHGGSGSYSVCSNSDTK 154
Cdd:pfam06682 230 SSQSSQQGGENSWrPGFWTGAATGGAAGYLFGRRRNRNNNTNYRGYRGSGWGGGSYRSSSPSFGSAGSSSASSSTSSSSS 309

                         170
                  ....*....|...
gi 545746309  155 TRTASGYGGTRRR 167
Cdd:pfam06682 310 TRTSTGFGGTRRR 322
 
Name Accession Description Interval E-value
SARAF pfam06682
SOCE-associated regulatory factor of calcium homoeostasis; SARAF is as family of eukaryotic ...
 1-167 3.95e-25

SOCE-associated regulatory factor of calcium homoeostasis; SARAF is as family of eukaryotic proteins embedded in the ER. SARAF is SOCE-associated regulatory factor, where SOCE is store operated calcium entry. ie a mechanism governing calcium homoeostasis in the cell and the mitochondria. SOCE involves the enabling of Ca2+ release-activated Ca2+ (CRAC) channels. SARAF is a single pass ER membrane protein whose systolic-facing domain is responsible for activity and whose luminary-facing domain carries out a regulatory function in conjunction with another membrane protein STIM, an ER single pass membrane protein that detects changes in ER Ca2+ levels through its EF-hand, conserved Ca2+ binding domain. STIM is the major target for SARAF regulation, and thus SARAF negatively regulates the SOCE entry of calcium into cells protecting them from overfilling.


Pssm-ID: 461985  Cd Length: 322  Bit Score: 98.18  E-value: 3.95e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746309    1 MSGLITIVVLLGIAFVVYKLFLSDGQYSPPPYSEYPPF-----SHRYQRFTNSAGPPPPGFKSEFTGPQntghgatSGFG 75
Cdd:pfam06682 157 AGGLFWVAVLGVIAYIVYKAFLRSNRRYGPGGGRRGGGgggggGGGGGGDGNYNDPPPPYFKSGSSGSQ-------KPSS 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746309   76 SAFTGQQGYENSG-PGFWTGLGTGGILGYLFGSNRAATPFSDSWYYPSYPPSYPGTWNRAYSPLHGGSGSYSVCSNSDTK 154
Cdd:pfam06682 230 SSQSSQQGGENSWrPGFWTGAATGGAAGYLFGRRRNRNNNTNYRGYRGSGWGGGSYRSSSPSFGSAGSSSASSSTSSSSS 309

                         170
                  ....*....|...
gi 545746309  155 TRTASGYGGTRRR 167
Cdd:pfam06682 310 TRTSTGFGGTRRR 322
 
Name Accession Description Interval E-value
SARAF pfam06682
SOCE-associated regulatory factor of calcium homoeostasis; SARAF is as family of eukaryotic ...
 1-167 3.95e-25

SOCE-associated regulatory factor of calcium homoeostasis; SARAF is as family of eukaryotic proteins embedded in the ER. SARAF is SOCE-associated regulatory factor, where SOCE is store operated calcium entry. ie a mechanism governing calcium homoeostasis in the cell and the mitochondria. SOCE involves the enabling of Ca2+ release-activated Ca2+ (CRAC) channels. SARAF is a single pass ER membrane protein whose systolic-facing domain is responsible for activity and whose luminary-facing domain carries out a regulatory function in conjunction with another membrane protein STIM, an ER single pass membrane protein that detects changes in ER Ca2+ levels through its EF-hand, conserved Ca2+ binding domain. STIM is the major target for SARAF regulation, and thus SARAF negatively regulates the SOCE entry of calcium into cells protecting them from overfilling.


Pssm-ID: 461985  Cd Length: 322  Bit Score: 98.18  E-value: 3.95e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746309    1 MSGLITIVVLLGIAFVVYKLFLSDGQYSPPPYSEYPPF-----SHRYQRFTNSAGPPPPGFKSEFTGPQntghgatSGFG 75
Cdd:pfam06682 157 AGGLFWVAVLGVIAYIVYKAFLRSNRRYGPGGGRRGGGgggggGGGGGGDGNYNDPPPPYFKSGSSGSQ-------KPSS 229

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545746309   76 SAFTGQQGYENSG-PGFWTGLGTGGILGYLFGSNRAATPFSDSWYYPSYPPSYPGTWNRAYSPLHGGSGSYSVCSNSDTK 154
Cdd:pfam06682 230 SSQSSQQGGENSWrPGFWTGAATGGAAGYLFGRRRNRNNNTNYRGYRGSGWGGGSYRSSSPSFGSAGSSSASSSTSSSSS 309

                         170
                  ....*....|...
gi 545746309  155 TRTASGYGGTRRR 167
Cdd:pfam06682 310 TRTSTGFGGTRRR 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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