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Conserved domains on  [gi|553727226|ref|NP_001272961|]
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putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX32 isoform b [Mus musculus]

Protein Classification

DEAD-like_helicase_N and P-loop containing Nucleoside Triphosphate Hydrolases superfamily-containing protein( domain architecture ID 1015337)

DEAD-like_helicase_N and P-loop containing Nucleoside Triphosphate Hydrolases superfamily-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEAD-like_helicase_N super family cl28899
N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase ...
 1-104 6.16e-54

N-terminal helicase domain of the DEAD-box helicase superfamily; The DEAD-like helicase superfamily is a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. The N-terminal domain contains the ATP-binding region.


The actual alignment was detected with superfamily member cd17977:

Pssm-ID: 475120 [Multi-domain]  Cd Length: 176  Bit Score: 181.56  E-value: 6.16e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   1 MDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKL 80
Cdd:cd17977   73 MDVNIGHEVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKL 152

                         90       100
                 ....*....|....*....|....
gi 553727226  81 IVNCSPLLTSKLSSYYGDVPVIEV 104
Cdd:cd17977  153 VIITCPHLSSKLLSYYGNVPLIEV 176
HrpA super family cl34328
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
5-562 3.52e-51

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG1643:

Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 189.14  E-value: 3.52e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   5 IGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATD--------VLLGLlkdvllaRP 76
Cdd:COG1643   83 VGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADlllallldLQPAL-------RP 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226  77 ELKLIVncspllTS------KLSSYYGDVPVIEV--RNkHPVEVVYL--SGAQKDSFESVIRLIFEIHRSGEkGDVVVFL 146
Cdd:COG1643  156 DLKLLV------MSatldaeRFARLLGDAPVIESsgRT-YPVEVRYRplPADERDLEDAVADAVREALAEEP-GDILVFL 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 147 ACEQDIEKTYELvcqegsnLNPDVG-DLVVIPLY----PKEKCSLFRPVDETekrcqvyQRRVVLTTSCGESliwSHTV- 220
Cdd:COG1643  228 PGEREIRRTAEA-------LRGRLPpDTEILPLYgrlsAAEQDRAFAPAPHG-------RRRIVLATNIAET---SLTVp 290

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 221 --KFVIDVGLERRQVYNPRIRANSLVLQPISQSQAEIRKqllGS----SPsGKLFCLYTEE-FASkdMRPLKPAEMQEAN 293
Cdd:COG1643  291 giRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRA---GRagrlAP-GICYRLWSEEdFAR--RPAFTDPEILRAD 364

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 294 LTSMVLFMKR---VDIAGLgrcDFMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDC 370
Cdd:COG1643  365 LASLILELAAwglGDPEDL---PFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGC 441

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 371 VDEMLTIAAMVTAPscflHVPHGAeeaavtcwktflhPEGDHFTLINVYNAYQDTVLNsanehcvemwchdcFLSCSALR 450
Cdd:COG1643  442 LREAAILAALLSER----DPRRGA-------------AGSDLLARLNLWRRLREQQRE--------------FLSYLRLR 490

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 451 madviraELLEIIKRIELPYAEPAFGSKENGLNIKKALLSGYFMQIARDVDGSGNYLmLTHKQVAQLHPLSsySITKKmp 530
Cdd:COG1643  491 -------EWRDLARQLRRLLGEGANEEPADYEAIGLLLALAYPDRIARRRGEGGRYL-LARGRGAALFPGS--PLAKK-- 558

                        570       580       590
                 ....*....|....*....|....*....|....*...
gi 553727226 531 EWVLfhqfsISE------NNYIRVASAVSPELFMQLVP 562
Cdd:COG1643  559 EWLV-----AAElvggaaEARIRLAAPIDPEWLEELAA 591
 
Name Accession Description Interval E-value
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 1-104 6.16e-54

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 181.56  E-value: 6.16e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   1 MDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKL 80
Cdd:cd17977   73 MDVNIGHEVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKL 152

                         90       100
                 ....*....|....*....|....
gi 553727226  81 IVNCSPLLTSKLSSYYGDVPVIEV 104
Cdd:cd17977  153 VIITCPHLSSKLLSYYGNVPLIEV 176
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
5-562 3.52e-51

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 189.14  E-value: 3.52e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   5 IGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATD--------VLLGLlkdvllaRP 76
Cdd:COG1643   83 VGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADlllallldLQPAL-------RP 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226  77 ELKLIVncspllTS------KLSSYYGDVPVIEV--RNkHPVEVVYL--SGAQKDSFESVIRLIFEIHRSGEkGDVVVFL 146
Cdd:COG1643  156 DLKLLV------MSatldaeRFARLLGDAPVIESsgRT-YPVEVRYRplPADERDLEDAVADAVREALAEEP-GDILVFL 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 147 ACEQDIEKTYELvcqegsnLNPDVG-DLVVIPLY----PKEKCSLFRPVDETekrcqvyQRRVVLTTSCGESliwSHTV- 220
Cdd:COG1643  228 PGEREIRRTAEA-------LRGRLPpDTEILPLYgrlsAAEQDRAFAPAPHG-------RRRIVLATNIAET---SLTVp 290

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 221 --KFVIDVGLERRQVYNPRIRANSLVLQPISQSQAEIRKqllGS----SPsGKLFCLYTEE-FASkdMRPLKPAEMQEAN 293
Cdd:COG1643  291 giRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRA---GRagrlAP-GICYRLWSEEdFAR--RPAFTDPEILRAD 364

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 294 LTSMVLFMKR---VDIAGLgrcDFMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDC 370
Cdd:COG1643  365 LASLILELAAwglGDPEDL---PFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGC 441

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 371 VDEMLTIAAMVTAPscflHVPHGAeeaavtcwktflhPEGDHFTLINVYNAYQDTVLNsanehcvemwchdcFLSCSALR 450
Cdd:COG1643  442 LREAAILAALLSER----DPRRGA-------------AGSDLLARLNLWRRLREQQRE--------------FLSYLRLR 490

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 451 madviraELLEIIKRIELPYAEPAFGSKENGLNIKKALLSGYFMQIARDVDGSGNYLmLTHKQVAQLHPLSsySITKKmp 530
Cdd:COG1643  491 -------EWRDLARQLRRLLGEGANEEPADYEAIGLLLALAYPDRIARRRGEGGRYL-LARGRGAALFPGS--PLAKK-- 558

                        570       580       590
                 ....*....|....*....|....*....|....*...
gi 553727226 531 EWVLfhqfsISE------NNYIRVASAVSPELFMQLVP 562
Cdd:COG1643  559 EWLV-----AAElvggaaEARIRLAAPIDPEWLEELAA 591
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 108-272 9.99e-49

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 167.33  E-value: 9.99e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 108 HPVEVVYL-----------SGAQKDSFESVIRLIFEIHRSGEKGDVVVFLACEQDIEKTYELVcqEGSNLNPDVGDLVVI 176
Cdd:cd18791    1 FPVEVYYLedilellgissEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELL--REELLSPDLGKLLVL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 177 PLYPKEKCSLFRPVDEtekRCQVYQRRVVLTTSCGESLIWSHTVKFVIDVGLERRQVYNPRIRANSLVLQPISQSQAEIR 256
Cdd:cd18791   79 PLHSSLPPEEQQRVFE---PPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQR 155

                        170
                 ....*....|....*.
gi 553727226 257 KQLLGSSPSGKLFCLY 272
Cdd:cd18791  156 AGRAGRTRPGKCYRLY 171
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 1-555 8.97e-37

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 147.13  E-value: 8.97e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226    1 MDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKL 80
Cdd:PRK11131  142 LETELGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKV 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   81 IVNCSPLLTSKLSSYYGDVPVIEVRNK-HPVEVVY--LSGAQKDSFESVIRLIF----EIHRSGeKGDVVVFLACEQDIE 153
Cdd:PRK11131  222 IITSATIDPERFSRHFNNAPIIEVSGRtYPVEVRYrpIVEEADDTERDQLQAIFdavdELGREG-PGDILIFMSGEREIR 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226  154 KTYELVCQEgsnlnpDVGDLVVIPLYPK----EKCSLFRPVDetekrcqvyQRRVVLTTSCGESliwSHTV---KFVIDV 226
Cdd:PRK11131  301 DTADALNKL------NLRHTEILPLYARlsnsEQNRVFQSHS---------GRRIVLATNVAET---SLTVpgiKYVIDP 362

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226  227 GLERRQVYNPRIRANSLVLQPISQSQAEIRKQLLGSSPSGKLFCLYTEE-FASkdmRP-LKPAEMQEANLTSMVLFMKRV 304
Cdd:PRK11131  363 GTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDdFLS---RPeFTDPEILRTNLASVILQMTAL 439

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226  305 DIAGLGRCDFMNRPAPESLMQALEDLDYLAALDNDGN-----LSEFGIIMSEFPLDPQLSKSILASCEFDCVDEMLTIAA 379
Cdd:PRK11131  440 GLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEQasaykLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITS 519

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226  380 MVTA--PScflHVPHGAEEAAVTCWKTFLHPEGDHFTLINVYNaY---QDTVLnSANEhcVEMWCHDCFLSCSALRMADV 454
Cdd:PRK11131  520 ALSIqdPR---ERPMDKQQASDEKHRRFADKESDFLAFVNLWN-YlqeQQKAL-SSNQ--FRRLCRTDYLNYLRVREWQD 592

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226  455 IRAELLEIIKRIELPY-AEPAfgskeNGLNIKKALLSGYFMQIA-RDVD-----GSGNylmlthkqvAQLHPLSSYSITK 527
Cdd:PRK11131  593 IYTQLRQVVKELGIPVnSEPA-----EYREIHTALLTGLLSHIGmKDAEkqeytGARN---------ARFSIFPGSGLFK 658

                         570       580
                  ....*....|....*....|....*...
gi 553727226  528 KMPEWVLFHQFSISENNYIRVASAVSPE 555
Cdd:PRK11131  659 KPPKWVMVAELVETSRLWGRIAARIEPE 686
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 326-415 1.34e-24

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 98.46  E-value: 1.34e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226  326 ALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEMLTIAAMVTAPSCFLHVPHG---AEEAAVTCW 402
Cdd:pfam04408   1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLdprSAAKAARRR 80

                          90       100
                  ....*....|....*....|....
gi 553727226  403 KTFLHPE-----------GDHFTL 415
Cdd:pfam04408  81 RRAADEKarakfarldleGDHLTL 104
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 332-416 1.58e-22

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 91.56  E-value: 1.58e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   332 YLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEMLTIAAMVTAPSCFlhvPHGAEEAAVTCWKTFLHPEGD 411
Cdd:smart00847   1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR---PKEKREDADAARRRFADPESD 77


                   ....*
gi 553727226   412 HFTLI 416
Cdd:smart00847  78 HLTLL 82
 
Name Accession Description Interval E-value
DEXHc_DHX32 cd17977
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ...
 1-104 6.16e-54

DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350735 [Multi-domain]  Cd Length: 176  Bit Score: 181.56  E-value: 6.16e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   1 MDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKL 80
Cdd:cd17977   73 MDVNIGHEVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKL 152

                         90       100
                 ....*....|....*....|....
gi 553727226  81 IVNCSPLLTSKLSSYYGDVPVIEV 104
Cdd:cd17977  153 VIITCPHLSSKLLSYYGNVPLIEV 176
HrpA COG1643
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
5-562 3.52e-51

HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441249 [Multi-domain]  Cd Length: 836  Bit Score: 189.14  E-value: 3.52e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   5 IGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATD--------VLLGLlkdvllaRP 76
Cdd:COG1643   83 VGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADlllallldLQPAL-------RP 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226  77 ELKLIVncspllTS------KLSSYYGDVPVIEV--RNkHPVEVVYL--SGAQKDSFESVIRLIFEIHRSGEkGDVVVFL 146
Cdd:COG1643  156 DLKLLV------MSatldaeRFARLLGDAPVIESsgRT-YPVEVRYRplPADERDLEDAVADAVREALAEEP-GDILVFL 227

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 147 ACEQDIEKTYELvcqegsnLNPDVG-DLVVIPLY----PKEKCSLFRPVDETekrcqvyQRRVVLTTSCGESliwSHTV- 220
Cdd:COG1643  228 PGEREIRRTAEA-------LRGRLPpDTEILPLYgrlsAAEQDRAFAPAPHG-------RRRIVLATNIAET---SLTVp 290

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 221 --KFVIDVGLERRQVYNPRIRANSLVLQPISQSQAEIRKqllGS----SPsGKLFCLYTEE-FASkdMRPLKPAEMQEAN 293
Cdd:COG1643  291 giRYVIDSGLARIPRYDPRSGVTRLPTERISQASANQRA---GRagrlAP-GICYRLWSEEdFAR--RPAFTDPEILRAD 364

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 294 LTSMVLFMKR---VDIAGLgrcDFMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDC 370
Cdd:COG1643  365 LASLILELAAwglGDPEDL---PFLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGC 441

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 371 VDEMLTIAAMVTAPscflHVPHGAeeaavtcwktflhPEGDHFTLINVYNAYQDTVLNsanehcvemwchdcFLSCSALR 450
Cdd:COG1643  442 LREAAILAALLSER----DPRRGA-------------AGSDLLARLNLWRRLREQQRE--------------FLSYLRLR 490

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 451 madviraELLEIIKRIELPYAEPAFGSKENGLNIKKALLSGYFMQIARDVDGSGNYLmLTHKQVAQLHPLSsySITKKmp 530
Cdd:COG1643  491 -------EWRDLARQLRRLLGEGANEEPADYEAIGLLLALAYPDRIARRRGEGGRYL-LARGRGAALFPGS--PLAKK-- 558

                        570       580       590
                 ....*....|....*....|....*....|....*...
gi 553727226 531 EWVLfhqfsISE------NNYIRVASAVSPELFMQLVP 562
Cdd:COG1643  559 EWLV-----AAElvggaaEARIRLAAPIDPEWLEELAA 591
SF2_C_RHA cd18791
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ...
 108-272 9.99e-49

C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350178 [Multi-domain]  Cd Length: 171  Bit Score: 167.33  E-value: 9.99e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 108 HPVEVVYL-----------SGAQKDSFESVIRLIFEIHRSGEKGDVVVFLACEQDIEKTYELVcqEGSNLNPDVGDLVVI 176
Cdd:cd18791    1 FPVEVYYLedilellgissEKEDPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELL--REELLSPDLGKLLVL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 177 PLYPKEKCSLFRPVDEtekRCQVYQRRVVLTTSCGESLIWSHTVKFVIDVGLERRQVYNPRIRANSLVLQPISQSQAEIR 256
Cdd:cd18791   79 PLHSSLPPEEQQRVFE---PPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQR 155

                        170
                 ....*....|....*.
gi 553727226 257 KQLLGSSPSGKLFCLY 272
Cdd:cd18791  156 AGRAGRTRPGKCYRLY 171
PRK11131 PRK11131
ATP-dependent RNA helicase HrpA; Provisional
 1-555 8.97e-37

ATP-dependent RNA helicase HrpA; Provisional


Pssm-ID: 182986 [Multi-domain]  Cd Length: 1294  Bit Score: 147.13  E-value: 8.97e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226    1 MDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKL 80
Cdd:PRK11131  142 LETELGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKV 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   81 IVNCSPLLTSKLSSYYGDVPVIEVRNK-HPVEVVY--LSGAQKDSFESVIRLIF----EIHRSGeKGDVVVFLACEQDIE 153
Cdd:PRK11131  222 IITSATIDPERFSRHFNNAPIIEVSGRtYPVEVRYrpIVEEADDTERDQLQAIFdavdELGREG-PGDILIFMSGEREIR 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226  154 KTYELVCQEgsnlnpDVGDLVVIPLYPK----EKCSLFRPVDetekrcqvyQRRVVLTTSCGESliwSHTV---KFVIDV 226
Cdd:PRK11131  301 DTADALNKL------NLRHTEILPLYARlsnsEQNRVFQSHS---------GRRIVLATNVAET---SLTVpgiKYVIDP 362

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226  227 GLERRQVYNPRIRANSLVLQPISQSQAEIRKQLLGSSPSGKLFCLYTEE-FASkdmRP-LKPAEMQEANLTSMVLFMKRV 304
Cdd:PRK11131  363 GTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDdFLS---RPeFTDPEILRTNLASVILQMTAL 439

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226  305 DIAGLGRCDFMNRPAPESLMQALEDLDYLAALDNDGN-----LSEFGIIMSEFPLDPQLSKSILASCEFDCVDEMLTIAA 379
Cdd:PRK11131  440 GLGDIAAFPFVEAPDKRNIQDGVRLLEELGAITTDEQasaykLTPLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITS 519

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226  380 MVTA--PScflHVPHGAEEAAVTCWKTFLHPEGDHFTLINVYNaY---QDTVLnSANEhcVEMWCHDCFLSCSALRMADV 454
Cdd:PRK11131  520 ALSIqdPR---ERPMDKQQASDEKHRRFADKESDFLAFVNLWN-YlqeQQKAL-SSNQ--FRRLCRTDYLNYLRVREWQD 592

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226  455 IRAELLEIIKRIELPY-AEPAfgskeNGLNIKKALLSGYFMQIA-RDVD-----GSGNylmlthkqvAQLHPLSSYSITK 527
Cdd:PRK11131  593 IYTQLRQVVKELGIPVnSEPA-----EYREIHTALLTGLLSHIGmKDAEkqeytGARN---------ARFSIFPGSGLFK 658

                         570       580
                  ....*....|....*....|....*...
gi 553727226  528 KMPEWVLFHQFSISENNYIRVASAVSPE 555
Cdd:PRK11131  659 KPPKWVMVAELVETSRLWGRIAARIEPE 686
DEXHc_RHA-like cd17917
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ...
 1-104 2.12e-34

DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438707 [Multi-domain]  Cd Length: 159  Bit Score: 127.96  E-value: 2.12e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   1 MDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKL 80
Cdd:cd17917   56 RGEKLGEEVGYQIRFESKTSSKTRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKV 135

                         90       100
                 ....*....|....*....|....
gi 553727226  81 IVNCSPLLTSKLSSYYGDVPVIEV 104
Cdd:cd17917  136 ILMSATLDAEKFSSYFGGAPVIHI 159
DEXQc_DQX1 cd17986
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ...
 1-104 3.58e-34

DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350744 [Multi-domain]  Cd Length: 177  Bit Score: 128.09  E-value: 3.58e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   1 MDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKL 80
Cdd:cd17986   74 MDLNLGHEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRV 153

                         90       100
                 ....*....|....*....|....
gi 553727226  81 IVNCSPLLTSKLSSYYGDVPVIEV 104
Cdd:cd17986  154 VVVTSPALEPKLRAFWGNPPVVHV 177
DEXHc_DHX15 cd17973
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ...
 1-104 2.39e-30

DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438709 [Multi-domain]  Cd Length: 187  Bit Score: 117.52  E-value: 2.39e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   1 MDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKL 80
Cdd:cd17973   84 MDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPDLKL 163

                         90       100
                 ....*....|....*....|....
gi 553727226  81 IVNCSPLLTSKLSSYYGDVPVIEV 104
Cdd:cd17973  164 IVMSATLDAGKFQKYFDNAPLLKV 187
DEXHc_DHX16 cd17974
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ...
 1-104 1.15e-28

DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350732 [Multi-domain]  Cd Length: 174  Bit Score: 112.21  E-value: 1.15e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   1 MDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKL 80
Cdd:cd17974   71 MGVKLGNEVGYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKL 150

                         90       100
                 ....*....|....*....|....
gi 553727226  81 IVNCSPLLTSKLSSYYGDVPVIEV 104
Cdd:cd17974  151 LISSATMDAEKFSAFFDDAPIFRI 174
DEXHc_DHX8 cd17971
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ...
 5-104 2.47e-26

DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350729 [Multi-domain]  Cd Length: 179  Bit Score: 106.03  E-value: 2.47e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   5 IGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKLIVNC 84
Cdd:cd17971   79 LGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTS 158

                         90       100
                 ....*....|....*....|
gi 553727226  85 SPLLTSKLSSYYGDVPVIEV 104
Cdd:cd17971  159 ATLDAVKFSQYFYEAPIFTI 178
HA2 pfam04408
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ...
 326-415 1.34e-24

Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 461295 [Multi-domain]  Cd Length: 104  Bit Score: 98.46  E-value: 1.34e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226  326 ALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEMLTIAAMVTAPSCFLHVPHG---AEEAAVTCW 402
Cdd:pfam04408   1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFLdprSAAKAARRR 80

                          90       100
                  ....*....|....*....|....
gi 553727226  403 KTFLHPE-----------GDHFTL 415
Cdd:pfam04408  81 RRAADEKarakfarldleGDHLTL 104
DEXHc_DHX38 cd17983
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ...
 1-104 3.18e-24

DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350741 [Multi-domain]  Cd Length: 173  Bit Score: 99.84  E-value: 3.18e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   1 MDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKL 80
Cdd:cd17983   70 MGVELGEEVGYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKL 149

                         90       100
                 ....*....|....*....|....
gi 553727226  81 IVNCSPLLTSKLSSYYGDVPVIEV 104
Cdd:cd17983  150 IVTSATMDADKFADFFGNVPIFTI 173
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
 4-383 3.22e-24

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 107.70  E-value: 3.22e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   4 NIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLA-RPELKLIV 82
Cdd:PRK11664  75 KPGETVGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQGlRDDLKLLI 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226  83 NCSPLLTSKLSSYYGDVPVIEVRNK-HPVEVVYLSGAQKDSF-ESVIRLIFEIHRSgEKGDVVVFLACEQDIEKTYELvc 160
Cdd:PRK11664 155 MSATLDNDRLQQLLPDAPVIVSEGRsFPVERRYQPLPAHQRFdEAVARATAELLRQ-ESGSLLLFLPGVGEIQRVQEQ-- 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 161 qegsnLNPDVGDLVVI-PLY----PKEKCSLFRPVDetekrcqVYQRRVVLTTSCGESliwSHT---VKFVIDVGLERRQ 232
Cdd:PRK11664 232 -----LASRVASDVLLcPLYgalsLAEQQKAILPAP-------AGRRKVVLATNIAET---SLTiegIRLVVDSGLERVA 296

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226 233 VYNPRIRANSLVLQPISQSQAEIRKQLLGSSPSGKLFCLYTEEFASKdmRPLKP-AEMQEANLTSMVLfmkrvDIAGLGR 311
Cdd:PRK11664 297 RFDPKTGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAER--AAAQSePEILHSDLSGLLL-----ELLQWGC 369

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 553727226 312 CD-----FMNRPAPESLMQALEDLDYLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDcvDEMLTIAAMVTA 383
Cdd:PRK11664 370 HDpaqlsWLDQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLAAMLVAAKEDD--EAALATAAKLAA 444
HA2 smart00847
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ...
 332-416 1.58e-22

Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.


Pssm-ID: 214852 [Multi-domain]  Cd Length: 82  Bit Score: 91.56  E-value: 1.58e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   332 YLAALDNDGNLSEFGIIMSEFPLDPQLSKSILASCEFDCVDEMLTIAAMVTAPSCFlhvPHGAEEAAVTCWKTFLHPEGD 411
Cdd:smart00847   1 ELGALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR---PKEKREDADAARRRFADPESD 77


                   ....*
gi 553727226   412 HFTLI 416
Cdd:smart00847  78 HLTLL 82
DEXHc_DHX33 cd17978
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ...
 1-102 3.32e-22

DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438710 [Multi-domain]  Cd Length: 178  Bit Score: 93.96  E-value: 3.32e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   1 MDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLAR----- 75
Cdd:cd17978   70 MGVELGQLVGYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRkeqkl 149

                         90       100
                 ....*....|....*....|....*..
gi 553727226  76 PELKLIVNCSPLLTSKLSSYYGDVPVI 102
Cdd:cd17978  150 SPLKVIIMSATLDADLFSEYFNGAPVL 176
DEXHc_DHX35 cd17980
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ...
 1-96 6.39e-22

DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350738 [Multi-domain]  Cd Length: 185  Bit Score: 93.30  E-value: 6.39e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   1 MDVNIGHEVGYVIPFENCCTT-ETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELK 79
Cdd:cd17980   71 MGAVLGHEVGYCIRFDDCTDPqATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLR 150

                         90
                 ....*....|....*..
gi 553727226  80 LIVNCSPLLTSKLSSYY 96
Cdd:cd17980  151 LIVASATLDAEKFRDFF 167
OB_NTP_bind pfam07717
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ...
 484-564 2.18e-21

Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.


Pssm-ID: 400182 [Multi-domain]  Cd Length: 82  Bit Score: 88.46  E-value: 2.18e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226  484 IKKALLSGYFMQIARDVDGSGNYLMLTHKQVAQLHPLSSY-SITKKMPEWVLFHQFSISENNYIRVASAVSPELFMQLVP 562
Cdd:pfam07717   1 LRAALAAGLYPNVARRDPKGKGYTTLSDNQRVFIHPSSVLfNEKTFPPEWVVYQELVETTKVYIRTVTAISPEWLLLFAP 80


                  ..
gi 553727226  563 QY 564
Cdd:pfam07717  81 HI 82
DEXHc_DHX40 cd17984
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ...
 1-104 4.78e-20

DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350742 [Multi-domain]  Cd Length: 178  Bit Score: 87.99  E-value: 4.78e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   1 MDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDV-----LLGLLKDVLLAR 75
Cdd:cd17984   70 MKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDIlfgllKKLFQEKSPNRK 149

                         90       100
                 ....*....|....*....|....*....
gi 553727226  76 PELKLIVNCSPLLTSKLSSYYGDVPVIEV 104
Cdd:cd17984  150 EHLKVVVMSATLELAKLSAFFGNCPVFDI 178
DEXHc_DHX34 cd17979
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ...
 6-104 1.01e-15

DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350737 [Multi-domain]  Cd Length: 170  Bit Score: 75.17  E-value: 1.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   6 GHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKLIVNCS 85
Cdd:cd17979   72 GSKVAYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSA 151

                         90
                 ....*....|....*....
gi 553727226  86 PLLTSKLSSYYGDVPVIEV 104
Cdd:cd17979  152 TINIELFSGYFEGAPVVQV 170
DEXHc_HrpB cd17990
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ...
 5-104 3.05e-14

DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 438711 [Multi-domain]  Cd Length: 174  Bit Score: 71.21  E-value: 3.05e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   5 IGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLA-RPELKLIVN 83
Cdd:cd17990   74 PGETVGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLlRDDLRLLAM 153

                         90       100
                 ....*....|....*....|.
gi 553727226  84 CSPLLTSKLSSYYGDVPVIEV 104
Cdd:cd17990  154 SATLDGDGLAALLPEAPVVES 174
DEXHc_HrpA cd17989
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ...
 1-104 3.95e-14

DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350747 [Multi-domain]  Cd Length: 173  Bit Score: 70.56  E-value: 3.95e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   1 MDVNIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKL 80
Cdd:cd17989   70 LKTELGGAVGYKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKV 149

                         90       100
                 ....*....|....*....|....
gi 553727226  81 IVNCSPLLTSKLSSYYGDVPVIEV 104
Cdd:cd17989  150 IITSATIDAERFSRHFNNAPIIEV 173
DEXHc_DHX57 cd17985
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ...
 5-104 4.27e-13

DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350743 [Multi-domain]  Cd Length: 177  Bit Score: 67.94  E-value: 4.27e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   5 IGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKLIVNC 84
Cdd:cd17985   78 VGQSVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMS 157

                         90       100
                 ....*....|....*....|
gi 553727226  85 SPLLTSKLSSYYGDVPVIEV 104
Cdd:cd17985  158 ATLNAELFSDYFNSCPVIHI 177
DEXHc_DHX36 cd17981
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ...
 6-104 3.91e-12

DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350739 [Multi-domain]  Cd Length: 180  Bit Score: 65.25  E-value: 3.91e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   6 GHEVGYVIPFENCCTTE--TILrYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKLIVN 83
Cdd:cd17981   81 GNSTGYQIRLESRKPRKqgSIL-YCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILM 159

                         90       100
                 ....*....|....*....|.
gi 553727226  84 CSPLLTSKLSSYYGDVPVIEV 104
Cdd:cd17981  160 SATLNAEKFSDYFNNCPMIHI 180
DEXHc_YTHDC2 cd17987
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ...
 4-104 3.44e-11

DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350745 [Multi-domain]  Cd Length: 176  Bit Score: 62.15  E-value: 3.44e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   4 NIGHEVGYVIPFENCCTTETILRYCTDDMLQREMMS-NPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKLIV 82
Cdd:cd17987   75 KIGQTVGYQIRLESRVSPKTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLIL 154

                         90       100
                 ....*....|....*....|..
gi 553727226  83 NCSPLLTSKLSSYYGDVPVIEV 104
Cdd:cd17987  155 SSAALDVNLFIRYFGSCPVIYI 176
DEXHc_DHX37 cd17982
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ...
 6-63 3.55e-11

DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350740 [Multi-domain]  Cd Length: 191  Bit Score: 62.76  E-value: 3.55e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 553727226   6 GHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDV 63
Cdd:cd17982   79 GKEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDI 136
DEXHc_DHX30 cd17976
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ...
 4-104 6.80e-10

DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350734 [Multi-domain]  Cd Length: 178  Bit Score: 58.65  E-value: 6.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   4 NIGHEVGYVIPFENCCTTET-ILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKLIV 82
Cdd:cd17976   77 NLRRNVGYQVRLESRPPPRGgALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVL 156

                         90       100
                 ....*....|....*....|..
gi 553727226  83 NCSPLLTSKLSSYYGDVPVIEV 104
Cdd:cd17976  157 MSATGDNQRLSRYFGGCPVVRV 178
DEXHc_DHX29 cd17975
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ...
 10-104 1.05e-09

DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350733 [Multi-domain]  Cd Length: 183  Bit Score: 58.00  E-value: 1.05e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226  10 GYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATDVLLGLLKDVLLARPELKLIVNCSPLLT 89
Cdd:cd17975   89 GYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHLILMSATVDC 168

                         90
                 ....*....|....*
gi 553727226  90 SKLSSYYGDVPVIEV 104
Cdd:cd17975  169 EKFSSYFTHCPILRI 183
DEXHc_DHX9 cd17972
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ...
 5-104 7.26e-07

DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350730 [Multi-domain]  Cd Length: 234  Bit Score: 50.60  E-value: 7.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 553727226   5 IGHEVGYVIPFENCCTTE--TILrYCTDDMLQREMMSnpflGSYGV--IILDDVHERSLATDVLLGLLKDVLLARPELKL 80
Cdd:cd17972  136 VGKSCGYSVRFESVLPRPhaSIL-FCTVGVLLRKLEA----GIRGIshVIVDEIHERDINTDFLLVVLRDVVQAYPDLRV 210

                         90       100
                 ....*....|....*....|....
gi 553727226  81 IVNCSPLLTSKLSSYYGDVPVIEV 104
Cdd:cd17972  211 ILMSATIDTSMFCEYFFNCPVIEV 234
DEXHc_TDRD9 cd17988
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ...
 5-62 1.11e-04

DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350746 [Multi-domain]  Cd Length: 180  Bit Score: 43.26  E-value: 1.11e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 553727226   5 IGHEVGYVIPFENCCTTETILRYCTDDMLQREMMSNPFLGSYGVIILDDVHERSLATD 62
Cdd:cd17988   76 LGSLVGYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELD 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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