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Conserved domains on  [gi|554790388|ref|NP_001273062|]
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ribonuclease P protein subunit p40 isoform c [Homo sapiens]

Protein Classification

ribonuclease P protein subunit p40( domain architecture ID 10554211)

ribonuclease P protein subunit p40 is a component of both ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends, and the MRP ribonuclease complex, which cleaves pre-rRNA sequences

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ribonuc_P_40 pfam08584
Ribonuclease P 40kDa (Rpp40) subunit; The tRNA processing enzyme ribonuclease P (RNase P) ...
75-301 1.69e-107

Ribonuclease P 40kDa (Rpp40) subunit; The tRNA processing enzyme ribonuclease P (RNase P) consists of an RNA molecule and at least eight protein subunits. Subunits hpop1, Rpp21, Rpp29, Rpp30, Rpp38, and Rpp40 (this entry) are involved in extensive, but weak, protein-protein interactions in the holoenzyme complex.


:

Pssm-ID: 462526  Cd Length: 277  Bit Score: 314.64  E-value: 1.69e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554790388   75 HELITPEFISTFIKKGSCYALTYNTHIDEDNTVALLPNGKLILSLDKDTYEETGLQGHPSQFSGRKIMKF---------- 144
Cdd:pfam08584   1 SELLEHEFLETYIKKGSVYALSYNTRIDSDNVVALLPNGTLILSLDKDTYERLGLEGKPSRFGGRKKQRYvveldlrdps 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554790388  145 ------------------------------------SSEESTMMSYFSKYQIQEHQPKVALSTLRDLQCPVL-QSSELEG 187
Cdd:pfam08584  81 flpgkkgyervrwalknrltlsfdflfswdptpssgGALSSILASLLKNYQIIECQPSISTTTLRDVLCPSLeLESEYSQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554790388  188 TPEVSCRALELFDWLGAVFSNVDLNNE---PNNFISTYCCPEPSTVVAKAYLCTITGFILPEKICLLLEHLCHYFDEPKL 264
Cdd:pfam08584 161 ENELSCSALELLEWLGLVSLGSPRVNAddaIDPYLSTYSCPEPSEKTGEVTSLTWTGFIPPEWILGLLEKLRRYVAEPKL 240
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 554790388  265 APWVTLSVQGFADSPVSWEKNEHGFRKGGEHLYNFVI 301
Cdd:pfam08584 241 APWFALTVHGFADSPVSWGEREHGFLKGGENDYTILI 277
 
Name Accession Description Interval E-value
Ribonuc_P_40 pfam08584
Ribonuclease P 40kDa (Rpp40) subunit; The tRNA processing enzyme ribonuclease P (RNase P) ...
75-301 1.69e-107

Ribonuclease P 40kDa (Rpp40) subunit; The tRNA processing enzyme ribonuclease P (RNase P) consists of an RNA molecule and at least eight protein subunits. Subunits hpop1, Rpp21, Rpp29, Rpp30, Rpp38, and Rpp40 (this entry) are involved in extensive, but weak, protein-protein interactions in the holoenzyme complex.


Pssm-ID: 462526  Cd Length: 277  Bit Score: 314.64  E-value: 1.69e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554790388   75 HELITPEFISTFIKKGSCYALTYNTHIDEDNTVALLPNGKLILSLDKDTYEETGLQGHPSQFSGRKIMKF---------- 144
Cdd:pfam08584   1 SELLEHEFLETYIKKGSVYALSYNTRIDSDNVVALLPNGTLILSLDKDTYERLGLEGKPSRFGGRKKQRYvveldlrdps 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554790388  145 ------------------------------------SSEESTMMSYFSKYQIQEHQPKVALSTLRDLQCPVL-QSSELEG 187
Cdd:pfam08584  81 flpgkkgyervrwalknrltlsfdflfswdptpssgGALSSILASLLKNYQIIECQPSISTTTLRDVLCPSLeLESEYSQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554790388  188 TPEVSCRALELFDWLGAVFSNVDLNNE---PNNFISTYCCPEPSTVVAKAYLCTITGFILPEKICLLLEHLCHYFDEPKL 264
Cdd:pfam08584 161 ENELSCSALELLEWLGLVSLGSPRVNAddaIDPYLSTYSCPEPSEKTGEVTSLTWTGFIPPEWILGLLEKLRRYVAEPKL 240
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 554790388  265 APWVTLSVQGFADSPVSWEKNEHGFRKGGEHLYNFVI 301
Cdd:pfam08584 241 APWFALTVHGFADSPVSWGEREHGFLKGGENDYTILI 277
 
Name Accession Description Interval E-value
Ribonuc_P_40 pfam08584
Ribonuclease P 40kDa (Rpp40) subunit; The tRNA processing enzyme ribonuclease P (RNase P) ...
75-301 1.69e-107

Ribonuclease P 40kDa (Rpp40) subunit; The tRNA processing enzyme ribonuclease P (RNase P) consists of an RNA molecule and at least eight protein subunits. Subunits hpop1, Rpp21, Rpp29, Rpp30, Rpp38, and Rpp40 (this entry) are involved in extensive, but weak, protein-protein interactions in the holoenzyme complex.


Pssm-ID: 462526  Cd Length: 277  Bit Score: 314.64  E-value: 1.69e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554790388   75 HELITPEFISTFIKKGSCYALTYNTHIDEDNTVALLPNGKLILSLDKDTYEETGLQGHPSQFSGRKIMKF---------- 144
Cdd:pfam08584   1 SELLEHEFLETYIKKGSVYALSYNTRIDSDNVVALLPNGTLILSLDKDTYERLGLEGKPSRFGGRKKQRYvveldlrdps 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554790388  145 ------------------------------------SSEESTMMSYFSKYQIQEHQPKVALSTLRDLQCPVL-QSSELEG 187
Cdd:pfam08584  81 flpgkkgyervrwalknrltlsfdflfswdptpssgGALSSILASLLKNYQIIECQPSISTTTLRDVLCPSLeLESEYSQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 554790388  188 TPEVSCRALELFDWLGAVFSNVDLNNE---PNNFISTYCCPEPSTVVAKAYLCTITGFILPEKICLLLEHLCHYFDEPKL 264
Cdd:pfam08584 161 ENELSCSALELLEWLGLVSLGSPRVNAddaIDPYLSTYSCPEPSEKTGEVTSLTWTGFIPPEWILGLLEKLRRYVAEPKL 240
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 554790388  265 APWVTLSVQGFADSPVSWEKNEHGFRKGGEHLYNFVI 301
Cdd:pfam08584 241 APWFALTVHGFADSPVSWGEREHGFLKGGENDYTILI 277
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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