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Conserved domains on  [gi|557129007|ref|NP_001273408|]
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rho GTPase-activating protein 11A isoform 3 [Homo sapiens]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 1569)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

CATH:  1.10.555.10
Gene Ontology:  GO:0007165|GO:0005096
PubMed:  17222083|12480336
SCOP:  4001255

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP super family cl02570
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 1-57 3.21e-27

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


The actual alignment was detected with superfamily member cd04394:

Pssm-ID: 470621 [Multi-domain]  Cd Length: 202  Bit Score: 109.87  E-value: 3.21e-27
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 557129007   1 MDSSNLAVIFAPNLLQTSEGHEKMSSNTEKKLRLQAAVVQTLIDYASDIGRVPDFIL 57
Cdd:cd04394  146 MDSSNLAVIFAPNLFQSEEGGEKMSSSTEKRLRLQAAVVQTLIDNASNIGIVPDFIL 202
 
Name Accession Description Interval E-value
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1-57 3.21e-27

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 109.87  E-value: 3.21e-27
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 557129007   1 MDSSNLAVIFAPNLLQTSEGHEKMSSNTEKKLRLQAAVVQTLIDYASDIGRVPDFIL 57
Cdd:cd04394  146 MDSSNLAVIFAPNLFQSEEGGEKMSSSTEKRLRLQAAVVQTLIDNASNIGIVPDFIL 202
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 1-46 2.77e-06

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 48.42  E-value: 2.77e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 557129007     1 MDSSNLAVIFAPNLLQTSEGHEKMSSNTekklRLQAAVVQTLIDYA 46
Cdd:smart00324 133 MTARNLAIVFGPTLLRPPDGEVASLKDI----RHQNTVIEFLIENA 174
 
Name Accession Description Interval E-value
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1-57 3.21e-27

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 109.87  E-value: 3.21e-27
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 557129007   1 MDSSNLAVIFAPNLLQTSEGHEKMSSNTEKKLRLQAAVVQTLIDYASDIGRVPDFIL 57
Cdd:cd04394  146 MDSSNLAVIFAPNLFQSEEGGEKMSSSTEKRLRLQAAVVQTLIDNASNIGIVPDFIL 202
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 1-46 2.77e-06

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 48.42  E-value: 2.77e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 557129007     1 MDSSNLAVIFAPNLLQTSEGHEKMSSNTekklRLQAAVVQTLIDYA 46
Cdd:smart00324 133 MTARNLAIVFGPTLLRPPDGEVASLKDI----RHQNTVIEFLIENA 174
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1-53 6.42e-05

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 44.74  E-value: 6.42e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 557129007   1 MDSSNLAVIFAPNLLQTSEGHEKMSSNTEKKL---RLQAAVVQTLIDYASDIGRVP 53
Cdd:cd04376  148 MTSLNLATIFGPNLLHKQKSGEREFVQASLRIeesTAIINVVQTMIDNYEELFMVS 203
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 1-45 1.91e-04

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 43.06  E-value: 1.91e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 557129007   1 MDSSNLAVIFAPNLLQTSEGHEKMSSNTEKklrlQAAVVQTLIDY 45
Cdd:cd00159  129 MTASNLAIVFAPTLLRPPDSDDELLEDIKK----LNEIVEFLIEN 169
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 1-49 2.83e-03

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 39.59  E-value: 2.83e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 557129007   1 MDSSNLAVIFAPNLLQTSEGHEKMSSNTEKKLRLqaavVQTLIDYASDI 49
Cdd:cd04402  143 MDAFNLAVCIAPSLLWPPASSELQNEDLKKVTSL----VQFLIENCQEI 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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