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Conserved domains on  [gi|558472797|ref|NP_001273764|]
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zinc-regulated GTPase metalloprotein activator 1E isoform b [Homo sapiens]

Protein Classification

GTP-binding protein( domain architecture ID 10542307)

GTP-binding protein such as GTPase YjiA, a GTP dependent regulatory protein, and CobW, which is involved in the synthesis of cobalamin

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CobW_C pfam07683
Cobalamin synthesis protein cobW C-terminal domain; This is a large and diverse family of ...
 55-154 1.99e-20

Cobalamin synthesis protein cobW C-terminal domain; This is a large and diverse family of putative metal chaperones that can be separated into up to 15 subgroups. In addition to known roles in cobalamin biosynthesis and the activation of the Fe-type nitrile hydratase, this family is also known to be involved in the response to zinc limitation. The CobW subgroup involved in cobalamin synthesis represents only a small sub-fraction of the family.


:

Pssm-ID: 462228 [Multi-domain]  Cd Length: 93  Bit Score: 80.75  E-value: 1.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472797   55 IVTITFEVPGNAKEEHLNMFIQNLLWEKNVrnkdnhcmevIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDtER 134
Cdd:pfam07683   1 ISSFVFRADRPFDPERLEAWLEDLLLPEGI----------LRAKGILWLAGRPRPLVFQGVGGRLSLEPAGRWWPDE-DR 69

                          90       100
                  ....*....|....*....|
gi 558472797  135 TNRLVLIGRNLDKDILKQLF 154
Cdd:pfam07683  70 RSRLVFIGRDLDREALRAAL 89
 
Name Accession Description Interval E-value
CobW_C pfam07683
Cobalamin synthesis protein cobW C-terminal domain; This is a large and diverse family of ...
 55-154 1.99e-20

Cobalamin synthesis protein cobW C-terminal domain; This is a large and diverse family of putative metal chaperones that can be separated into up to 15 subgroups. In addition to known roles in cobalamin biosynthesis and the activation of the Fe-type nitrile hydratase, this family is also known to be involved in the response to zinc limitation. The CobW subgroup involved in cobalamin synthesis represents only a small sub-fraction of the family.


Pssm-ID: 462228 [Multi-domain]  Cd Length: 93  Bit Score: 80.75  E-value: 1.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472797   55 IVTITFEVPGNAKEEHLNMFIQNLLWEKNVrnkdnhcmevIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDtER 134
Cdd:pfam07683   1 ISSFVFRADRPFDPERLEAWLEDLLLPEGI----------LRAKGILWLAGRPRPLVFQGVGGRLSLEPAGRWWPDE-DR 69

                          90       100
                  ....*....|....*....|
gi 558472797  135 TNRLVLIGRNLDKDILKQLF 154
Cdd:pfam07683  70 RSRLVFIGRDLDREALRAAL 89
YejR COG0523
Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction ...
 17-154 2.87e-15

Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction only];


Pssm-ID: 440289 [Multi-domain]  Cd Length: 318  Bit Score: 71.74  E-value: 2.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472797  17 RVDLSNVLDLHAFDSLSGISLQKKLQhvPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIqnllweknvrnkDNHCMEVIR 96
Cdd:COG0523  189 EVDPALLLDLGLFDLEAALARPGWLE--ELRDHEHDDGIRSFVFRSDRPFDPERLADFL------------EELGPGVLR 254

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 558472797  97 LKGLVSIKDKSQQVIVQGVHELYDLEETPvSWKDDtERTNRLVLIGRNLDKDILKQLF 154
Cdd:COG0523  255 AKGFLWLAGRPRRLVFQGVGGRLSLEPLG-PWPAD-DRRSRLVFIGRDLDEAALEAAL 310
CobW_C smart00833
Cobalamin synthesis protein cobW C-terminal domain; CobW proteins are generally found proximal ...
 94-154 1.72e-08

Cobalamin synthesis protein cobW C-terminal domain; CobW proteins are generally found proximal to the trimeric cobaltochelatase subunit CobN, which is essential for vitamin B12 (cobalamin) biosynthesis. They contain a P-loop nucleotide-binding loop in the N-terminal domain and a histidine-rich region in the C-terminal portion suggesting a role in metal binding, possibly as an intermediary between the cobalt transport and chelation systems. CobW might be involved in cobalt reduction leading to cobalt(I) corrinoids. This entry represents the C-terminal domain found in CobW, as well as in P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression.


Pssm-ID: 214844 [Multi-domain]  Cd Length: 92  Bit Score: 49.52  E-value: 1.72e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 558472797    94 VIRLKGLVSIKDKSQQVIV-QGVHELYDLEETPVsWKDDTERTNRLVLIGRNLDKDILKQLF 154
Cdd:smart00833  28 VLRAKGFFWLASRPDLPGVlSQAGGRLRIEPAGA-WPAAGDRRTRLVFIGRDLDEEAIRAAL 88
 
Name Accession Description Interval E-value
CobW_C pfam07683
Cobalamin synthesis protein cobW C-terminal domain; This is a large and diverse family of ...
 55-154 1.99e-20

Cobalamin synthesis protein cobW C-terminal domain; This is a large and diverse family of putative metal chaperones that can be separated into up to 15 subgroups. In addition to known roles in cobalamin biosynthesis and the activation of the Fe-type nitrile hydratase, this family is also known to be involved in the response to zinc limitation. The CobW subgroup involved in cobalamin synthesis represents only a small sub-fraction of the family.


Pssm-ID: 462228 [Multi-domain]  Cd Length: 93  Bit Score: 80.75  E-value: 1.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472797   55 IVTITFEVPGNAKEEHLNMFIQNLLWEKNVrnkdnhcmevIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDtER 134
Cdd:pfam07683   1 ISSFVFRADRPFDPERLEAWLEDLLLPEGI----------LRAKGILWLAGRPRPLVFQGVGGRLSLEPAGRWWPDE-DR 69

                          90       100
                  ....*....|....*....|
gi 558472797  135 TNRLVLIGRNLDKDILKQLF 154
Cdd:pfam07683  70 RSRLVFIGRDLDREALRAAL 89
YejR COG0523
Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction ...
 17-154 2.87e-15

Zinc metallochaperone YeiR/ZagA and related GTPases, G3E family [General function prediction only];


Pssm-ID: 440289 [Multi-domain]  Cd Length: 318  Bit Score: 71.74  E-value: 2.87e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472797  17 RVDLSNVLDLHAFDSLSGISLQKKLQhvPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIqnllweknvrnkDNHCMEVIR 96
Cdd:COG0523  189 EVDPALLLDLGLFDLEAALARPGWLE--ELRDHEHDDGIRSFVFRSDRPFDPERLADFL------------EELGPGVLR 254

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 558472797  97 LKGLVSIKDKSQQVIVQGVHELYDLEETPvSWKDDtERTNRLVLIGRNLDKDILKQLF 154
Cdd:COG0523  255 AKGFLWLAGRPRRLVFQGVGGRLSLEPLG-PWPAD-DRRSRLVFIGRDLDEAALEAAL 310
CobW_C smart00833
Cobalamin synthesis protein cobW C-terminal domain; CobW proteins are generally found proximal ...
 94-154 1.72e-08

Cobalamin synthesis protein cobW C-terminal domain; CobW proteins are generally found proximal to the trimeric cobaltochelatase subunit CobN, which is essential for vitamin B12 (cobalamin) biosynthesis. They contain a P-loop nucleotide-binding loop in the N-terminal domain and a histidine-rich region in the C-terminal portion suggesting a role in metal binding, possibly as an intermediary between the cobalt transport and chelation systems. CobW might be involved in cobalt reduction leading to cobalt(I) corrinoids. This entry represents the C-terminal domain found in CobW, as well as in P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression.


Pssm-ID: 214844 [Multi-domain]  Cd Length: 92  Bit Score: 49.52  E-value: 1.72e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 558472797    94 VIRLKGLVSIKDKSQQVIV-QGVHELYDLEETPVsWKDDTERTNRLVLIGRNLDKDILKQLF 154
Cdd:smart00833  28 VLRAKGFFWLASRPDLPGVlSQAGGRLRIEPAGA-WPAAGDRRTRLVFIGRDLDEEAIRAAL 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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