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Conserved domains on  [gi|559767186|ref|NP_001274012|]
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desmocollin 2-like protein [Danio rerio]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 11279609)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 279-377 5.56e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.44  E-value: 5.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186 279 FFTVEERCRAGTRVGQVNATDRDQPktPHSLIKYILL--NATDMFSIDQSTGIITAKSnTLDREAQDKVFVGVEIRDMGG 356
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVsgNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDGGG 79

                         90       100
                 ....*....|....*....|.
gi 559767186 357 APngLFNRGTAVISLTDVNDN 377
Cdd:cd11304   80 PP--LSSTATVTITVLDVNDN 98
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 66-140 2.52e-18

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


:

Pssm-ID: 214999  Cd Length: 87  Bit Score: 80.40  E-value: 2.52e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186    66 CDPR----PVLVQVPNTVPAGYFITQVTLNGCTAIP-VSFTSSDPDFTVNTDGSIVTLRSLVISTKR--FSVLVQDNSGL 138
Cdd:smart01055   1 CKPGfseeKYTFHVPSHLEAGQPLGRVNFEECLGSArLQFESSDPDFRVLEDGTVYATRPVSLSSEKksFTVLAWDSQGQ 80


                   ..
gi 559767186   139 DW 140
Cdd:smart01055  81 EK 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 498-596 2.34e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.43  E-value: 2.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186 498 IMYLKVKENLPNGTVIGTYKALDPETKNSNGIKYYKLT-DPGNWITVVESTGELKVANTIDRESslvhNDTYNITIKAVD 576
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|..
gi 559767186 577 --ESKKTGNGVVILQIEDVNDN 596
Cdd:cd11304   77 ggGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 192-272 5.87e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 5.87e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186   192 SDSSVNYTVHYVISGQGVTeepiGLFQLDQKTGMVRVTGPVDREKNPEFNFIARAFDQNNREVDQFLPITVMVEDVNDNA 271
Cdd:smart00112   5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 559767186   272 P 272
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 386-490 5.84e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.49  E-value: 5.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186 386 YKGTIKENLA-NVLVTRIPVEDKDLvnTPNWKAVYEVTKGNENGNFRMetDPKTneGLLYVVKGLDFEKTPVMNLEVTAR 464
Cdd:cd11304    2 YEVSVPENAPpGTVVLTVSATDPDS--GENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*.
gi 559767186 465 NEaplvGTDAKWQSVPLQLNVEDVDE 490
Cdd:cd11304   76 DG----GGPPLSSTATVTITVLDVND 97
CADH_Y-type_LIR super family cl03079
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 879-926 2.51e-05

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


The actual alignment was detected with superfamily member pfam01049:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 42.52  E-value: 2.51e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 559767186  879 DDLLkNYGNEGVGSSAGSVgcCSIL----GEQESMEFLNTLGPKFRPLADIC 926
Cdd:pfam01049  11 DSLQ-TYAYEGDGSSAGSL--SSLEsstsDSDQDYDYLSDWGPRFKKLAELY 59
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 279-377 5.56e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.44  E-value: 5.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186 279 FFTVEERCRAGTRVGQVNATDRDQPktPHSLIKYILL--NATDMFSIDQSTGIITAKSnTLDREAQDKVFVGVEIRDMGG 356
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVsgNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDGGG 79

                         90       100
                 ....*....|....*....|.
gi 559767186 357 APngLFNRGTAVISLTDVNDN 377
Cdd:cd11304   80 PP--LSSTATVTITVLDVNDN 98
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 66-140 2.52e-18

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 80.40  E-value: 2.52e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186    66 CDPR----PVLVQVPNTVPAGYFITQVTLNGCTAIP-VSFTSSDPDFTVNTDGSIVTLRSLVISTKR--FSVLVQDNSGL 138
Cdd:smart01055   1 CKPGfseeKYTFHVPSHLEAGQPLGRVNFEECLGSArLQFESSDPDFRVLEDGTVYATRPVSLSSEKksFTVLAWDSQGQ 80


                   ..
gi 559767186   139 DW 140
Cdd:smart01055  81 EK 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 498-596 2.34e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.43  E-value: 2.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186 498 IMYLKVKENLPNGTVIGTYKALDPETKNSNGIKYYKLT-DPGNWITVVESTGELKVANTIDRESslvhNDTYNITIKAVD 576
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|..
gi 559767186 577 --ESKKTGNGVVILQIEDVNDN 596
Cdd:cd11304   77 ggGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 192-272 5.87e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 5.87e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186   192 SDSSVNYTVHYVISGQGVTeepiGLFQLDQKTGMVRVTGPVDREKNPEFNFIARAFDQNNREVDQFLPITVMVEDVNDNA 271
Cdd:smart00112   5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 559767186   272 P 272
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 170-270 6.14e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 6.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186 170 PLPFSVVENASPPFP------KDvemiaSDSSVNYTVHYVISGQGvteePIGLFQLDQKTGMVRVTGPVDREKNPEFNFI 243
Cdd:cd11304    1 SYEVSVPENAPPGTVvltvsaTD-----PDSGENGEVTYSIVSGN----EDGLFSIDPSTGEITTAKPLDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....*..
gi 559767186 244 ARAFDQNNREVDQFLPITVMVEDVNDN 270
Cdd:cd11304   72 VTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 296-379 3.78e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 3.78e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186   296 NATDRDQPktPHSLIKYILL--NATDMFSIDQSTGIITAKSnTLDREAQDKVFVGVEIRDMGGAPngLFNRGTAVISLTD 373
Cdd:smart00112   1 SATDADSG--ENGKVTYSILsgNDDGLFSIDPETGEITTTK-PLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLD 75


                   ....*.
gi 559767186   374 VNDNPP 379
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
280-372 1.71e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 1.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186  280 FTVEERCRAGTRVGQVNATDRDQPktPHSLIKYILL--NATDMFSIDQSTGIITAKSNtLDREAQDKVFVGVEIRDMGGA 357
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILggGPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|....*
gi 559767186  358 PngLFNRGTAVISLT 372
Cdd:pfam00028  80 P--LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 386-490 5.84e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.49  E-value: 5.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186 386 YKGTIKENLA-NVLVTRIPVEDKDLvnTPNWKAVYEVTKGNENGNFRMetDPKTneGLLYVVKGLDFEKTPVMNLEVTAR 464
Cdd:cd11304    2 YEVSVPENAPpGTVVLTVSATDPDS--GENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*.
gi 559767186 465 NEaplvGTDAKWQSVPLQLNVEDVDE 490
Cdd:cd11304   76 DG----GGPPLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
503-591 1.23e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.33  E-value: 1.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186  503 VKENLPNGTVIGTYKALDPETKNSNGIKYYKL-TDPGNWITVVESTGELKVANTIDRESslvhNDTYNITIKAVDESK-- 579
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGGpp 80

                          90
                  ....*....|..
gi 559767186  580 KTGNGVVILQIE 591
Cdd:pfam00028  81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
386-486 8.00e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.32  E-value: 8.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186  386 YKGTIKENLA-NVLVTRIPVEDKDLvnTPNWKAVYEVTKGNENGNFRMETDPktneGLLYVVKGLDFEKTPVMNLEVTAR 464
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|..
gi 559767186  465 NEaplvGTDAKWQSVPLQLNVE 486
Cdd:pfam00028  75 DS----GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 517-598 3.59e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.97  E-value: 3.59e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186   517 KALDPETKNSNGIKYYKLT-DPGNWITVVESTGELKVANTIDRESslvhNDTYNITIKAVDESK--KTGNGVVILQIEDV 593
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREE----QPEYTLTVEATDGGGppLSSTATVTITVLDV 76


                   ....*
gi 559767186   594 NDNIP 598
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 404-492 2.82e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.66  E-value: 2.82e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186   404 VEDKDLvnTPNWKAVYEVTKGNENGNFRMetDPKTneGLLYVVKGLDFEKTPVMNLEVTARNEaplvGTDAKWQSVPLQL 483
Cdd:smart00112   2 ATDADS--GENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDG----GGPPLSSTATVTI 71


                   ....*....
gi 559767186   484 NVEDVDEGP 492
Cdd:smart00112  72 TVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
172-265 3.47e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.61  E-value: 3.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186  172 PFSVVENASP-PFPKDVEMIASDSSVNYTVHYVISGQGvteePIGLFQLDQKTGMVRVTGPVDREKNPEFNFIARAFDQN 250
Cdd:pfam00028   2 SASVPENAPVgTEVLTVTATDPDLGPNGRIFYSILGGG----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 559767186  251 NREVDQFLPITVMVE 265
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 75-146 1.72e-06

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 46.93  E-value: 1.72e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 559767186   75 VPNTVPAGYFITQVTLNGCTAIP-VSFTSSDPDFTVNTDGSIVTLRSLVISTKR--FSVLVQDNSGLD-WRVEIIL 146
Cdd:pfam08758  15 VPRRLEEGQPLLNVKFNDCTGRKkTLYESSDPRFKVNTDGTVTAKRPVTLHGRQtsFLVHAWDSHGEKmASVKVTV 90
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 879-926 2.51e-05

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 42.52  E-value: 2.51e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 559767186  879 DDLLkNYGNEGVGSSAGSVgcCSIL----GEQESMEFLNTLGPKFRPLADIC 926
Cdd:pfam01049  11 DSLQ-TYAYEGDGSSAGSL--SSLEsstsDSDQDYDYLSDWGPRFKKLAELY 59
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 279-377 5.56e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 85.44  E-value: 5.56e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186 279 FFTVEERCRAGTRVGQVNATDRDQPktPHSLIKYILL--NATDMFSIDQSTGIITAKSnTLDREAQDKVFVGVEIRDMGG 356
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDPDSG--ENGEVTYSIVsgNEDGLFSIDPSTGEITTAK-PLDREEQSSYTLTVTATDGGG 79

                         90       100
                 ....*....|....*....|.
gi 559767186 357 APngLFNRGTAVISLTDVNDN 377
Cdd:cd11304   80 PP--LSSTATVTITVLDVNDN 98
Cadherin_pro smart01055
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 66-140 2.52e-18

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 214999  Cd Length: 87  Bit Score: 80.40  E-value: 2.52e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186    66 CDPR----PVLVQVPNTVPAGYFITQVTLNGCTAIP-VSFTSSDPDFTVNTDGSIVTLRSLVISTKR--FSVLVQDNSGL 138
Cdd:smart01055   1 CKPGfseeKYTFHVPSHLEAGQPLGRVNFEECLGSArLQFESSDPDFRVLEDGTVYATRPVSLSSEKksFTVLAWDSQGQ 80


                   ..
gi 559767186   139 DW 140
Cdd:smart01055  81 EK 82
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 498-596 2.34e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 75.43  E-value: 2.34e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186 498 IMYLKVKENLPNGTVIGTYKALDPETKNSNGIKYYKLT-DPGNWITVVESTGELKVANTIDRESslvhNDTYNITIKAVD 576
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSgNEDGLFSIDPSTGEITTAKPLDREE----QSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|..
gi 559767186 577 --ESKKTGNGVVILQIEDVNDN 596
Cdd:cd11304   77 ggGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 192-272 5.87e-16

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 73.54  E-value: 5.87e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186   192 SDSSVNYTVHYVISGQGVTeepiGLFQLDQKTGMVRVTGPVDREKNPEFNFIARAFDQNNREVDQFLPITVMVEDVNDNA 271
Cdd:smart00112   5 ADSGENGKVTYSILSGNDD----GLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 559767186   272 P 272
Cdd:smart00112  81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 170-270 6.14e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 6.14e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186 170 PLPFSVVENASPPFP------KDvemiaSDSSVNYTVHYVISGQGvteePIGLFQLDQKTGMVRVTGPVDREKNPEFNFI 243
Cdd:cd11304    1 SYEVSVPENAPPGTVvltvsaTD-----PDSGENGEVTYSIVSGN----EDGLFSIDPSTGEITTAKPLDREEQSSYTLT 71

                         90       100
                 ....*....|....*....|....*..
gi 559767186 244 ARAFDQNNREVDQFLPITVMVEDVNDN 270
Cdd:cd11304   72 VTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 296-379 3.78e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 71.23  E-value: 3.78e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186   296 NATDRDQPktPHSLIKYILL--NATDMFSIDQSTGIITAKSnTLDREAQDKVFVGVEIRDMGGAPngLFNRGTAVISLTD 373
Cdd:smart00112   1 SATDADSG--ENGKVTYSILsgNDDGLFSIDPETGEITTTK-PLDREEQPEYTLTVEATDGGGPP--LSSTATVTITVLD 75


                   ....*.
gi 559767186   374 VNDNPP 379
Cdd:smart00112  76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
280-372 1.71e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.64  E-value: 1.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186  280 FTVEERCRAGTRVGQVNATDRDQPktPHSLIKYILL--NATDMFSIDQSTGIITAKSNtLDREAQDKVFVGVEIRDMGGA 357
Cdd:pfam00028   3 ASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILggGPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|....*
gi 559767186  358 PngLFNRGTAVISLT 372
Cdd:pfam00028  80 P--LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 386-490 5.84e-14

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 68.49  E-value: 5.84e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186 386 YKGTIKENLA-NVLVTRIPVEDKDLvnTPNWKAVYEVTKGNENGNFRMetDPKTneGLLYVVKGLDFEKTPVMNLEVTAR 464
Cdd:cd11304    2 YEVSVPENAPpGTVVLTVSATDPDS--GENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTAT 75

                         90       100
                 ....*....|....*....|....*.
gi 559767186 465 NEaplvGTDAKWQSVPLQLNVEDVDE 490
Cdd:cd11304   76 DG----GGPPLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
503-591 1.23e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 67.33  E-value: 1.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186  503 VKENLPNGTVIGTYKALDPETKNSNGIKYYKL-TDPGNWITVVESTGELKVANTIDRESslvhNDTYNITIKAVDESK-- 579
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILgGGPGGNFRIDPDTGDISTTKPLDRES----IGEYELTVEATDSGGpp 80

                          90
                  ....*....|..
gi 559767186  580 KTGNGVVILQIE 591
Cdd:pfam00028  81 LSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
386-486 8.00e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 62.32  E-value: 8.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186  386 YKGTIKENLA-NVLVTRIPVEDKDLvnTPNWKAVYEVTKGNENGNFRMETDPktneGLLYVVKGLDFEKTPVMNLEVTAR 464
Cdd:pfam00028   1 YSASVPENAPvGTEVLTVTATDPDL--GPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEAT 74

                          90       100
                  ....*....|....*....|..
gi 559767186  465 NEaplvGTDAKWQSVPLQLNVE 486
Cdd:pfam00028  75 DS----GGPPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 172-270 1.05e-10

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 59.28  E-value: 1.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186 172 PFSVVENASPPfpKDVEMIASDSSVNYTVHYVISGQGvTEEPIGLFQLDQKTGMVRVTGPVDREKNPEFNFIARAFDQNN 251
Cdd:cd00031    3 DGSAVEGRSRG--SFRVSIPTDLIASSGEIIKISAAG-KEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGA 79

                         90
                 ....*....|....*....
gi 559767186 252 REVDQFLPITVMVEDVNDN 270
Cdd:cd00031   80 NVPQTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 517-598 3.59e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.97  E-value: 3.59e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186   517 KALDPETKNSNGIKYYKLT-DPGNWITVVESTGELKVANTIDRESslvhNDTYNITIKAVDESK--KTGNGVVILQIEDV 593
Cdd:smart00112   1 SATDADSGENGKVTYSILSgNDDGLFSIDPETGEITTTKPLDREE----QPEYTLTVEATDGGGppLSSTATVTITVLDV 76


                   ....*
gi 559767186   594 NDNIP 598
Cdd:smart00112  77 NDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 404-492 2.82e-09

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 54.66  E-value: 2.82e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186   404 VEDKDLvnTPNWKAVYEVTKGNENGNFRMetDPKTneGLLYVVKGLDFEKTPVMNLEVTARNEaplvGTDAKWQSVPLQL 483
Cdd:smart00112   2 ATDADS--GENGKVTYSILSGNDDGLFSI--DPET--GEITTTKPLDREEQPEYTLTVEATDG----GGPPLSSTATVTI 71


                   ....*....
gi 559767186   484 NVEDVDEGP 492
Cdd:smart00112  72 TVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
172-265 3.47e-09

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 54.61  E-value: 3.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 559767186  172 PFSVVENASP-PFPKDVEMIASDSSVNYTVHYVISGQGvteePIGLFQLDQKTGMVRVTGPVDREKNPEFNFIARAFDQN 250
Cdd:pfam00028   2 SASVPENAPVgTEVLTVTATDPDLGPNGRIFYSILGGG----PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 559767186  251 NREVDQFLPITVMVE 265
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
Cadherin_pro pfam08758
Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent ...
 75-146 1.72e-06

Cadherin prodomain like; Cadherins are a family of proteins that mediate calcium dependent cell-cell adhesion. They are activated through cleavage of a prosequence in the late Golgi. This domain corresponds to the folded region of the prosequence, and is termed the prodomain. The prodomain shows structural resemblance to the cadherin domain, but lacks all the features known to be important for cadherin-cadherin interactions.


Pssm-ID: 462590  Cd Length: 90  Bit Score: 46.93  E-value: 1.72e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 559767186   75 VPNTVPAGYFITQVTLNGCTAIP-VSFTSSDPDFTVNTDGSIVTLRSLVISTKR--FSVLVQDNSGLD-WRVEIIL 146
Cdd:pfam08758  15 VPRRLEEGQPLLNVKFNDCTGRKkTLYESSDPRFKVNTDGTVTAKRPVTLHGRQtsFLVHAWDSHGEKmASVKVTV 90
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 879-926 2.51e-05

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 42.52  E-value: 2.51e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 559767186  879 DDLLkNYGNEGVGSSAGSVgcCSIL----GEQESMEFLNTLGPKFRPLADIC 926
Cdd:pfam01049  11 DSLQ-TYAYEGDGSSAGSL--SSLEsstsDSDQDYDYLSDWGPRFKKLAELY 59
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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