|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NLS1_MFSD2A |
cd17451 |
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ... |
1-340 |
0e+00 |
|
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341009 Cd Length: 419 Bit Score: 538.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 1 MVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQAdtpcfqdlnsstvasqsanhthgttshr 80
Cdd:cd17451 112 LQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTVLGTAIQGQIVGMA---------------------------- 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 81 etqkAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFV 160
Cdd:cd17451 164 ----AYMIAAGVICAIYVLCAIILFLGVREQREPCELKSQKPVSFFKGLKLVMSHGPYIKLITGFLFTSLAFMLLEGNFA 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 161 LFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMESNLIITYAVAVAAGISVA 240
Cdd:cd17451 240 LFCTYTLGFRNDFQNILLVIMLSATLTIPFWQWFLTRFGKKTAVYIGISSAVPFLILVVLVESNLIVTYVVSVAAGVSVA 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 241 AAFLLPWSMLPDVIDDFHLKQPHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNMLVTM 320
Cdd:cd17451 320 AAFLLPWSMLPDVVDDFKLKNPDSQGHEAIFYSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPEEVNLTLKMLVSA 399
|
330 340
....*....|....*....|
gi 568214318 321 APIVLILLGLLLFKMYPIDE 340
Cdd:cd17451 400 APVVLILLGLLLFKLYPIDE 419
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
2-340 |
3.93e-66 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 215.64 E-value: 3.93e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 2 VTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGqadtpcfqdlnsstvasqsanhthGTTSHRE 81
Cdd:pfam13347 111 YTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVL------------------------ILGGTGL 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 82 TQKAYLLAAGVIVCIYIICAVILILGVRE---QREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGN 158
Cdd:pfam13347 167 ERKGYRIFALIGAVLMLLGVIITAAGTKErvsMRSKEDTGQKEAGSLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGL 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 159 FVLFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALM-ESNLIITYAVAVAAGI 237
Cdd:pfam13347 247 LLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLgPNNTLLFLVLYIIIGF 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 238 SVAAAFLLPWSMLPDVIDDFHLKQPHFHGTEpiFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNML 317
Cdd:pfam13347 327 GYGSSFFLPWSMLADVVDYGELRTGKRREGT--FFAMWSFISKLATGVGLGVSGLLLSAFGYNAGDSVQSPQAVTAIRLL 404
|
330 340
....*....|....*....|...
gi 568214318 318 VTMAPIVLILLGLLLFKMYPIDE 340
Cdd:pfam13347 405 YAVLPAVLFLVALLLLYFYPLDR 427
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
3-356 |
3.36e-46 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 163.53 E-value: 3.36e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 3 TCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQADTpcfqdlnsstvasqsanhthgttshrET 82
Cdd:COG2211 125 TLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGG--------------------------DA 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 83 QKAYLLAAGVIVCIYIICAVILILGVREQREPyeaqQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFVLF 162
Cdd:COG2211 179 ALGYRLTALIFAVLGLLAFLLTFFGTKERPVP----EEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYY 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 163 CTYTLGF-RNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGIS-SAVPFLILVALMESNLIITYAVAVAAGISVA 240
Cdd:COG2211 255 FKYVLGLsAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLlAALGLLLLFFLGPGNLWLLLVLAALAGIGLG 334
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 241 AAFLLPWSMLPDVIDDFHLKqpHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTrGCSQPERVKFTLNMLVTM 320
Cdd:COG2211 335 AILVLPWAMLADVVDYDEWK--TGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVA-GAAQSPSALTGIRLLFFL 411
|
330 340 350
....*....|....*....|....*....|....*.
gi 568214318 321 APIVLILLGLLLFKMYPIDEERRRQNKKALQALRDE 356
Cdd:COG2211 412 LPAVLLLLAALLLLFYPLTRERHAEIRAELAARRAA 447
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
1-342 |
4.36e-07 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 51.65 E-value: 4.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 1 MVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIV---GQADTpcfqdlnsstvasqsanhthgtt 77
Cdd:PRK09669 122 VYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGLIVSVIALPLVdilGKGDE----------------------- 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 78 shretQKAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSepiAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEG 157
Cdd:PRK09669 179 -----QKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVDNSS---SVWKDLKLLLGNSQWRIMFIFNVVLLTAVVTRGG 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 158 NFVLFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALME-SNLIITYAVAVAAG 236
Cdd:PRK09669 251 ATLYYVNYVLLRPDLATLFLVTGMIAGLFGALLSERLLGKFDRVRAFKWTIVAFVILSALIFFIPpSNVWLIFALNILFN 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 237 ISVAAAFLLPWSMLPDVIDdfHLKQPHFHGTEPIFFSFYVFFTKFasGVSLGISTL--SLDFAGYQTRGCSQPERVKFTL 314
Cdd:PRK09669 331 FIQNLTTPLQWSMFSDVVD--YEEKRSGRRLDGLVFSTNLFAIKL--GLAIGGAVVgwILAWVDYVGGAAVQSASVLTTI 406
|
330 340
....*....|....*....|....*...
gi 568214318 315 NMLVTMAPIVLILLGLLLFKMYPIDEER 342
Cdd:PRK09669 407 NLLFTVIPGVLFAGMAIILNFYKLNDAR 434
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_NLS1_MFSD2A |
cd17451 |
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of ... |
1-340 |
0e+00 |
|
Sodium-dependent lysophosphatidylcholine symporter 1 of the Major Facilitator Superfamily of transporters; Sodium-dependent lysophosphatidylcholine (LPC) symporter 1 (NLS1) is also called major facilitator superfamily domain-containing protein 2A (MFSD2A). NLS1/MFSD2A is an LPC symporter that plays an essential role for blood-brain barrier formation and function. It also transports the essential omega-3 fatty acid docosahexaenoic acid (DHA), which is essential for normal brain growth and cognitive function, in the form of LPC into the brain across the blood-brain barrier. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. NLS1/MFSD2A belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341009 Cd Length: 419 Bit Score: 538.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 1 MVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQAdtpcfqdlnsstvasqsanhthgttshr 80
Cdd:cd17451 112 LQTCFHVPYSALTMFISTEQKERDSATAYRMTVEVLGTVLGTAIQGQIVGMA---------------------------- 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 81 etqkAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFV 160
Cdd:cd17451 164 ----AYMIAAGVICAIYVLCAIILFLGVREQREPCELKSQKPVSFFKGLKLVMSHGPYIKLITGFLFTSLAFMLLEGNFA 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 161 LFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMESNLIITYAVAVAAGISVA 240
Cdd:cd17451 240 LFCTYTLGFRNDFQNILLVIMLSATLTIPFWQWFLTRFGKKTAVYIGISSAVPFLILVVLVESNLIVTYVVSVAAGVSVA 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 241 AAFLLPWSMLPDVIDDFHLKQPHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNMLVTM 320
Cdd:cd17451 320 AAFLLPWSMLPDVVDDFKLKNPDSQGHEAIFYSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPEEVNLTLKMLVSA 399
|
330 340
....*....|....*....|
gi 568214318 321 APIVLILLGLLLFKMYPIDE 340
Cdd:cd17451 400 APVVLILLGLLLFKLYPIDE 419
|
|
| MFS_MFSD2 |
cd17392 |
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator ... |
1-340 |
0e+00 |
|
Major facilitator superfamily domain-containing protein 2 subfamily; The major facilitator superfamily domain-containing protein 2 (MFSD2) subfamily is composed of two vertebrate members, MFSD2A amd MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. The MFSD2 subfamily belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340950 Cd Length: 446 Bit Score: 537.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 1 MVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQADTPCFQDLNSSTVASqsanhTHGTTSHR 80
Cdd:cd17392 112 FMTCFHVPYSALTMFLGGCQRERDSATAYRMTVEVFGTLMGATIQGQIVGVAHRPRRQDCTATPGTS-----DHPVTVLP 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 81 ETQKAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFV 160
Cdd:cd17392 187 NTRRAYLIAALVVVVLYFVCCSILFLGVKEQPDPLSPASGPGLSYLAGLKLVTGHPPYLKLVIGFLFSSLAFQMEQGNFV 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 161 LFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMESNLIITYAVAVAAGISVA 240
Cdd:cd17392 267 LFCTHAAGLGDHFQHLVLAILVSATLSIPLWQWVLQRRGKKTTSFIGISAMVPFLILLALVPSNLPVAYVVAVVSGVSLA 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 241 AAFLLPWSMLPDVIDDFHLKQPHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNMLVTM 320
Cdd:cd17392 347 ALFLLPWSMLPDVVDDFQLKNPHCPGLEPIFYSCYVFFTKLGGGLSLGISTLSLHFSGYKAGACKQPEEVVVTLKVLIAP 426
|
330 340
....*....|....*....|
gi 568214318 321 APIVLILLGLLLFKMYPIDE 340
Cdd:cd17392 427 VPICLILAGLVLFYVYPINE 446
|
|
| MFS_MFSD2B |
cd17452 |
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily ... |
1-340 |
4.06e-131 |
|
Major facilitator superfamily domain-containing protein 2B; Major facilitator superfamily domain-containing protein 2B (MFSD2B) is closely related to MFSD2A, and their conserved genomic structure suggests that they are derived from the duplication of an ancestral gene. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer identified MFSD2B as a potential risk or protect factor in the prognosis of lung adenocarcinoma. MFSD2B belongs to the Salmonella enterica Na+/melibiose symporter like (MelB-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341010 Cd Length: 416 Bit Score: 381.86 E-value: 4.06e-131
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 1 MVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQAdtpcfqdlnsstvasqsanhthgttshr 80
Cdd:cd17452 112 LATCFHVPYSALTMFLSTDQRERDSATAYRMTVEVLGTLVGAAVQGQIVASA---------------------------- 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 81 etqkaYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFV 160
Cdd:cd17452 164 -----YMIAAGVIGGLYLLCISVLFLGVKERDDPYAPKSGKAIPFFKGLSLTMRHGPYLKLTASFLFISAAVQLEQSNFV 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 161 LFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAvYVGISSAVPFLILVALMeSNLIITYAVAVAAGISVA 240
Cdd:cd17452 239 LFCTHAVDLHDHFQNLVLTILVSAVVSIPFWQWFLQRFGKKAA-ACGISWMIPFAIMLVTI-PNLIVAYVVAFVSGLSIA 316
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 241 AAFLLPWSMLPDVIDDFHLKQPHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNMLVTM 320
Cdd:cd17452 317 ASLLLPWSMLPDVVDDFRLQNPHGKGLETIFYSSYVFFTKLSAGIALGISTLSLEFAGYETGACKQPESVVLTLKLLIGA 396
|
330 340
....*....|....*....|
gi 568214318 321 APIVLILLGLLLFKMYPIDE 340
Cdd:cd17452 397 APTCMILIGLCILMFYPITE 416
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
3-340 |
4.78e-67 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 217.86 E-value: 4.78e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 3 TCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQADTPCfqdlnsstvasqsanhthgttshreT 82
Cdd:cd17332 114 TLVNIPYTALIPELTDDPEERTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGGN-------------------------A 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 83 QKAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPiAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFVLF 162
Cdd:cd17332 169 SRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKL-PLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLVYY 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 163 CTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALME-SNLIITYAVAVAAGISVAA 241
Cdd:cd17332 248 FKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPpGNLVLILVLAVLAGIGYGG 327
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 242 AFLLPWSMLPDVIDDFHLKqpHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNMLVTMA 321
Cdd:cd17332 328 ANLLPWAMLADVIDYGELK--TGKRREGIFYSVMTFFRKLGLALAGALVGLILSLAGYVANAAAQSASALNGIRLLIAVL 405
|
330
....*....|....*....
gi 568214318 322 PIVLILLGLLLFKMYPIDE 340
Cdd:cd17332 406 PAVLLLLALILMSFYPLDK 424
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
2-340 |
3.93e-66 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 215.64 E-value: 3.93e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 2 VTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGqadtpcfqdlnsstvasqsanhthGTTSHRE 81
Cdd:pfam13347 111 YTFFEIPYWSLGPELTRDYDERTSLTSYRSFFSVGGGLLAAALAFPLVL------------------------ILGGTGL 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 82 TQKAYLLAAGVIVCIYIICAVILILGVRE---QREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGN 158
Cdd:pfam13347 167 ERKGYRIFALIGAVLMLLGVIITAAGTKErvsMRSKEDTGQKEAGSLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGL 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 159 FVLFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALM-ESNLIITYAVAVAAGI 237
Cdd:pfam13347 247 LLYYFRYVLGNGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKNTYILGALITIAGFALALLLgPNNTLLFLVLYIIIGF 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 238 SVAAAFLLPWSMLPDVIDDFHLKQPHFHGTEpiFFSFYVFFTKFASGVSLGISTLSLDFAGYQTRGCSQPERVKFTLNML 317
Cdd:pfam13347 327 GYGSSFFLPWSMLADVVDYGELRTGKRREGT--FFAMWSFISKLATGVGLGVSGLLLSAFGYNAGDSVQSPQAVTAIRLL 404
|
330 340
....*....|....*....|...
gi 568214318 318 VTMAPIVLILLGLLLFKMYPIDE 340
Cdd:pfam13347 405 YAVLPAVLFLVALLLLYFYPLDR 427
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
3-356 |
3.36e-46 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 163.53 E-value: 3.36e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 3 TCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIVGQADTpcfqdlnsstvasqsanhthgttshrET 82
Cdd:COG2211 125 TLVNIPYSALGAELTPDYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGG--------------------------DA 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 83 QKAYLLAAGVIVCIYIICAVILILGVREQREPyeaqQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFVLF 162
Cdd:COG2211 179 ALGYRLTALIFAVLGLLAFLLTFFGTKERPVP----EEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYY 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 163 CTYTLGF-RNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGIS-SAVPFLILVALMESNLIITYAVAVAAGISVA 240
Cdd:COG2211 255 FKYVLGLsAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLlAALGLLLLFFLGPGNLWLLLVLAALAGIGLG 334
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 241 AAFLLPWSMLPDVIDDFHLKqpHFHGTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYQTrGCSQPERVKFTLNMLVTM 320
Cdd:COG2211 335 AILVLPWAMLADVVDYDEWK--TGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVA-GAAQSPSALTGIRLLFFL 411
|
330 340 350
....*....|....*....|....*....|....*.
gi 568214318 321 APIVLILLGLLLFKMYPIDEERRRQNKKALQALRDE 356
Cdd:COG2211 412 LPAVLLLLAALLLLFYPLTRERHAEIRAELAARRAA 447
|
|
| PRK09669 |
PRK09669 |
putative symporter YagG; Provisional |
1-342 |
4.36e-07 |
|
putative symporter YagG; Provisional
Pssm-ID: 236610 Cd Length: 444 Bit Score: 51.65 E-value: 4.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 1 MVTCFHVPYSALTMFISTEQTERDSATAYRMTVEVLGTVLGTAIQGQIV---GQADTpcfqdlnsstvasqsanhthgtt 77
Cdd:PRK09669 122 VYTAINVPYCAMPGAITNDPRERHSLQSWRFALSFIGGLIVSVIALPLVdilGKGDE----------------------- 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 78 shretQKAYLLAAGVIVCIYIICAVILILGVREQREPYEAQQSepiAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEG 157
Cdd:PRK09669 179 -----QKGYFYAMMVMGLLGVVLFFCCFFMTKERYTPEVDNSS---SVWKDLKLLLGNSQWRIMFIFNVVLLTAVVTRGG 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 158 NFVLFCTYTLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALME-SNLIITYAVAVAAG 236
Cdd:PRK09669 251 ATLYYVNYVLLRPDLATLFLVTGMIAGLFGALLSERLLGKFDRVRAFKWTIVAFVILSALIFFIPpSNVWLIFALNILFN 330
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 237 ISVAAAFLLPWSMLPDVIDdfHLKQPHFHGTEPIFFSFYVFFTKFasGVSLGISTL--SLDFAGYQTRGCSQPERVKFTL 314
Cdd:PRK09669 331 FIQNLTTPLQWSMFSDVVD--YEEKRSGRRLDGLVFSTNLFAIKL--GLAIGGAVVgwILAWVDYVGGAAVQSASVLTTI 406
|
330 340
....*....|....*....|....*...
gi 568214318 315 NMLVTMAPIVLILLGLLLFKMYPIDEER 342
Cdd:PRK09669 407 NLLFTVIPGVLFAGMAIILNFYKLNDAR 434
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
86-243 |
5.02e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.96 E-value: 5.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 86 YLLAAGVIVCIYIICAVILILG-------VREQREPYEAQQSEPIAYFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGN 158
Cdd:cd17325 142 LLADALGYRAPFLVCAALALLAlvlalllLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPF 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 159 FVLFCTYTLGFrNEFQN--LLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMeSNLIITYAVAVAAG 236
Cdd:cd17325 222 LPLYAAELGGL-SPAQIglLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA-TSFWLLLLLLALLG 299
|
....*..
gi 568214318 237 ISVAAAF 243
Cdd:cd17325 300 LGLGLVF 306
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
89-253 |
2.98e-05 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 45.64 E-value: 2.98e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 89 AAGVIVCIYIICAVILILGVREqrEPYEAQQSEPIAyFRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFVLFCTYTLG 168
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRD--PPAGAAAAAKAS-LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFG 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 169 FRNEFQNLLLAIM-LSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMESNLIITYAVAVAAGISVAAAFLLPW 247
Cdd:COG2223 238 LSAATAGLLAALFaLLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVF 317
|
....*.
gi 568214318 248 SMLPDV 253
Cdd:COG2223 318 ALVPDI 323
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
92-253 |
2.17e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 42.65 E-value: 2.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 92 VIVCIYIICAVILILGVREQREPYEAQQSepiayfRGLRLVMSHGPYIKLITGFLFTSLAFMLVEGNFVLFCTYTLGF-R 170
Cdd:COG2814 169 VNAVLALLALLLLLRLLPESRPAARARLR------GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLsA 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 171 NEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALMeSNLIITYAVAVAAGISVAAAFLLPWSML 250
Cdd:COG2814 243 SAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALA-GSLWLLLLALFLLGFGFGLLFPLLQALV 321
|
...
gi 568214318 251 PDV 253
Cdd:COG2814 322 AEL 324
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
87-243 |
2.28e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.93 E-value: 2.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 87 LLAAGVIVCIYIICAVILILGVREQREPYEAQQSEPIAYFRGLRLVMSHgpyIKLITGFLFTSLAFMLVEGNFV-LFCTY 165
Cdd:cd17478 148 GLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSSARSTLKGVWRA---LLLLLIIVFLRSWVLSSLTTFLpFYLVQ 224
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568214318 166 TLGFRNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTAVYVGISSAVPFLILVALmeSNLIITYAVAVAAGISVAAAF 243
Cdd:cd17478 225 RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLL--TPGIWSYILLVLAGFLLFASF 300
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
89-283 |
3.51e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 38.98 E-value: 3.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 89 AAGVIVCI-YIICAVILILGVREQREPYEAQQSEPIAY-FRGLRLVMSHGPYIKLITGFLftsLAFML----VEGNFVLF 162
Cdd:COG2270 185 ISFLLTALwWLLFALPLFLFLPERPRPGPAPPRGAVRAgFRELRRTLRELRRYRDLLRFL---LAYFFyrdgVQTVIAFA 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 163 CTY---TLGFrnEFQNLLLAIMLSATLTIP---IWQWFLTRFGKKTAVYVGISSAVPFLILVALMESNLIItYAVAVAAG 236
Cdd:COG2270 262 GIYaagVLGF--STTELIVFGLLVQIVAALgalLFGRLDDRIGPKRVILVSLVIWIVVCLAAYFLTTALAF-WILGLLIG 338
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 568214318 237 ISVAAAFLLPWSMLPDVIddfhlkqPHFHGTEpiFFSFYVFFTKFAS 283
Cdd:COG2270 339 LVMGGIQALSRSLLARLI-------PPGREAE--FFGLYALSGKAAS 376
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
129-243 |
4.72e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 38.66 E-value: 4.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 129 LRLVMSHGPYIKLITGflftslAFMLVEGNFVLFCTYTLGF--------RNEFQNLLLAIMLSATLTIPIWQWFLTRFGK 200
Cdd:cd17369 220 VEVLRRHWRALLLAIG------LRLAENVLFYLFTTFALSYatqtlgvdRSTVLLAVLIASVVAAITIPLFGWLSDRVGR 293
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 568214318 201 KTAVYVG----ISSAVPFLILVALmESNLIITYAVAVAAGISVAAAF 243
Cdd:cd17369 294 RPVYLAGallaALFAFPFFWLLDT-GSTWLIVLAAVVVLGVLHGMMY 339
|
|
| PRK10429 |
PRK10429 |
melibiose:sodium transporter MelB; |
92-372 |
4.83e-03 |
|
melibiose:sodium transporter MelB;
Pssm-ID: 182453 Cd Length: 473 Bit Score: 38.92 E-value: 4.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 92 VIVCIYIICAVILILGVREQREPYEAQQSEPIAY-FRG-LRLVMSHGPYIKLITGFLFTSLAFMLVEGNFVLFCTYTLGF 169
Cdd:PRK10429 185 VLIAFFIVSTIITLRNVHEVYSSDNQVSAEGSHLtLKDiVALIYKNDQLSCLLGMALAYNIASNIINGFAIYYFTYVIGD 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 170 RNEFQNLLLAIMLSATLTIPIWQWFLTRFGKKTaVYVGISSaVPFLILVALMesnLIITYAVAVAAGISVAAAFL----- 244
Cdd:PRK10429 265 ADLFPYYLSYAGAANLVTLILFPRLVKSLSRRI-LWAGASI-FPVLSCGVLL---LMGLAAPHNALLIVIAGILLnigta 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 245 LPWS----MLPDVID--DFHLKQPhfhgTEPIFFSFYVFFTKFASGVSLGISTLSLDFAGYqTRGCSQPERVKFTLNMLV 318
Cdd:PRK10429 340 LFWVlqviMVADTVDygEYKLGIR----CESIAYSVQTMVVKGGSAFAAFFIGVVLGLIGY-VPNVEQSAQTLLGMQFIM 414
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 568214318 319 TMAPIVLILLGLLL-FKMYPIDEERRRQNKKALQALRDEASSSGCSETDSTELAS 372
Cdd:PRK10429 415 IGLPTLFFMITLVLyFRYYRLNGDFLRRIQIHLLDKYRKVPPEPVHAEIPVGAVS 469
|
|
| PRK09952 |
PRK09952 |
shikimate transporter; Provisional |
78-234 |
8.30e-03 |
|
shikimate transporter; Provisional
Pssm-ID: 182163 [Multi-domain] Cd Length: 438 Bit Score: 38.17 E-value: 8.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 78 SHRETQKAYLLAAGVIVCIYIICAVILILGVR---EQREPYEAQQSEPIAYFRGLRLV---MSHGPYIKLITGFLFTSLA 151
Cdd:PRK09952 185 SMMTTDEQFLSWGWRIPFLFSIVLVLIALWVRngmEESAEFEQQQHEQAAAKKRIPVIealLRHPGAFLKIIALRLCELL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568214318 152 FMLVEGNFVL-FCTYTLGF-RNEFQNLLLAIMLSATLTIPIWQWFLTRFGKK----TAVYVGISSAVPFLILVALMESNL 225
Cdd:PRK09952 265 TMYIVTAFALnYSTQNLGLpRELFLNIGLLVGGLSCLTIPCFAWLADRFGRRrvyiTGALIGTLSAFPFFMALEAQSIFW 344
|
....*....
gi 568214318 226 IITYAVAVA 234
Cdd:PRK09952 345 IVFFSIMLA 353
|
|
|