|
Name |
Accession |
Description |
Interval |
E-value |
| PRK08315 |
PRK08315 |
AMP-binding domain protein; Validated |
57-602 |
0e+00 |
|
AMP-binding domain protein; Validated
Pssm-ID: 236236 [Multi-domain] Cd Length: 559 Bit Score: 750.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 57 GLSYVQGCTKKHLNSKTVGQCLETTAQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYA 136
Cdd:PRK08315 1 GLSYVRGPTDVPLLEQTIGQLLDRTAARYPDREALVYRDQGLRWTYREFNEEVDALAKGLLALGIEKGDRVGIWAPNVPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 137 WVLMQLATA-------------QAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEVENAQPGALKSQRLPDLTTV 203
Cdd:PRK08315 81 WVLTQFATAkigailvtinpayRLSELEYALNQSGCKALIAADGFKDSDYVAMLYELAPELATCEPGQLQSARLPELRRV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 204 ISVDA-PLPGTLLLDEVVAAGSTRqHLDQLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhe 282
Cdd:PRK08315 161 IFLGDeKHPGMLNFDELLALGRAV-DDAELAARQATLDPDDPINIQYTSGTTGFPKGATLTHRNILNNGYFIGEAMKL-- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 283 kTPEQlRMILPNPLYHCLGSVAGTMMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDIS 362
Cdd:PRK08315 238 -TEED-RLCIPVPLYHCFGMVLGNLACVTHGATMVYPGEGFDPLATLAAVEEERCTALYGVPTMFIAELDHPDFARFDLS 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 363 TMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAKL 442
Cdd:PRK08315 316 SLRTGIMAGSPCPIEVMKRVIDKMHMSEVTIAYGMTETSPVSTQTRTDDPLEKRVTTVGRALPHLEVKIVDPETGETVPR 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 443 NTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKV 522
Cdd:PRK08315 396 GEQGELCTRGYSVMKGYWNDPEKTAEAIDADGWMHTGDLAVMDEEGYVNIVGRIKDMIIRGGENIYPREIEEFLYTHPKI 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 523 QEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMERHLNL 602
Cdd:PRK08315 476 QDVQVVGVPDEKYGEEVCAWIILRPGATLTEEDVRDFCRGKIAHYKIPRYIRFVDEFPMTVTGKIQKFKMREMMIEELGL 555
|
|
| FACL_like_2 |
cd05917 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
241-593 |
0e+00 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341241 [Multi-domain] Cd Length: 349 Bit Score: 645.87 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 241 CHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhektPEQLRMILPNPLYHCLGSVAGTMMCLMYGATLILAS 320
Cdd:cd05917 1 PDDVINIQFTSGTTGSPKGATLTHHNIVNNGYFIGERLGL----TEQDRLCIPVPLFHCFGSVLGVLACLTHGATMVFPS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 321 PIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTEN 400
Cdd:cd05917 77 PSFDPLAVLEAIEKEKCTALHGVPTMFIAELEHPDFDKFDLSSLRTGIMAGAPCPPELMKRVIEVMNMKDVTIAYGMTET 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 401 SPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGD 480
Cdd:cd05917 157 SPVSTQTRTDDSIEKRVNTVGRIMPHTEAKIVDPEGGIVPPVGVPGELCIRGYSVMKGYWNDPEKTAEAIDGDGWLHTGD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 481 VATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFC 560
Cdd:cd05917 237 LAVMDEDGYCRIVGRIKDMIIRGGENIYPREIEEFLHTHPKVSDVQVVGVPDERYGEEVCAWIRLKEGAELTEEDIKAYC 316
|
330 340 350
....*....|....*....|....*....|...
gi 572879274 561 KGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 593
Cdd:cd05917 317 KGKIAHYKVPRYVFFVDEFPLTVSGKIQKFKLR 349
|
|
| PRK12583 |
PRK12583 |
acyl-CoA synthetase; Provisional |
57-596 |
0e+00 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 237145 [Multi-domain] Cd Length: 558 Bit Score: 632.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 57 GLSYVQGCTKKHLNSKTVGQCLETTAQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYA 136
Cdd:PRK12583 3 QPSYYQGGGDKPLLTQTIGDAFDATVARFPDREALVVRHQALRYTWRQLADAVDRLARGLLALGVQPGDRVGIWAPNCAE 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 137 WVLMQLATA-------------QAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEVENAQPGALKSQRLPDLTTV 203
Cdd:PRK12583 83 WLLTQFATArigailvninpayRASELEYALGQSGVRWVICADAFKTSDYHAMLQELLPGLAEGQPGALACERLPELRGV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 204 ISVD-APLPGTLLLDEVVAAGS--TRQHLDQLQynqQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKL 280
Cdd:PRK12583 163 VSLApAPPPGFLAWHELQARGEtvSREALAERQ---ASLDRDDPINIQYTSGTTGFPKGATLSHHNILNNGYFVAESLGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 281 HEKTpeqlRMILPNPLYHCLGSVAGTMMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYD 360
Cdd:PRK12583 240 TEHD----RLCVPVPLYHCFGMVLANLGCMTVGACLVYPNEAFDPLATLQAVEEERCTALYGVPTMFIAELDHPQRGNFD 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 361 ISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLA 440
Cdd:PRK12583 316 LSSLRTGIMAGAPCPIEVMRRVMDEMHMAEVQIAYGMTETSPVSLQTTAADDLERRVETVGRTQPHLEVKVVDPDGATVP 395
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 441 KLNTpGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHP 520
Cdd:PRK12583 396 RGEI-GELCTRGYSVMKGYWNNPEATAESIDEDGWMHTGDLATMDEQGYVRIVGRSKDMIIRGGENIYPREIEEFLFTHP 474
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 572879274 521 KVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQM 596
Cdd:PRK12583 475 AVADVQVFGVPDEKYGEEIVAWVRLHPGHAASEEELREFCKARIAHFKVPRYFRFVDEFPMTVTGKVQKFRMREIS 550
|
|
| MenE/FadK |
COG0318 |
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid ... |
74-599 |
1.30e-158 |
|
O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; O-succinylbenzoic acid-CoA ligase MenE or related acyl-CoA synthetase (AMP-forming) is part of the Pathway/BioSystem: Menaquinone biosynthesis
Pssm-ID: 440087 [Multi-domain] Cd Length: 452 Bit Score: 461.97 E-value: 1.30e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 74 VGQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQA------ 147
Cdd:COG0318 1 LADLLRRAAARHPDRPALV--FGGRRLTYAELDARARRLAAALRALGVGPGDRVALLLPNSPEFVVAFLAALRAgavvvp 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 148 -------MELEYVLKKVGCKALVFpkqfktqqyynvlkqicpevenaqpgalksqrlpdlttvisvdaplpgtllldevv 220
Cdd:COG0318 79 lnprltaEELAYILEDSGARALVT-------------------------------------------------------- 102
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 221 aagstrqhldqlqynqqflschdpINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCL 300
Cdd:COG0318 103 ------------------------ALILYTSGTTGRPKGVMLTHRNLLANAAAIAAALGLTPGD----VVLVALPLFHVF 154
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 301 GSVAGTMMCLMYGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIR 380
Cdd:COG0318 155 GLTVGLLAPLLAGATLVLL-PRFDPERVLELIERERVTVLFGVPTMLARLLRHPEFARYDLSSLRLVVSGGAPLPPELLE 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 381 AIINKINMKdLVVAYGTTENSPVTFAHfPEDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYW 460
Cdd:COG0318 234 RFEERFGVR-IVEGYGLTETSPVVTVN-PEDPGERRPGSVGRPLPGVEVRIVD-EDGRELPPGEVGEIVVRGPNVMKGYW 310
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 461 GEPQKTEEAVDqDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEIC 540
Cdd:COG0318 311 NDPEATAEAFR-DGWLRTGDLGRLDEDGYLYIVGRKKDMIISGGENVYPAEVEEVLAAHPGVAEAAVVGVPDEKWGERVV 389
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 572879274 541 ACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMERH 599
Cdd:COG0318 390 AFVVLRPGAELDAEELRAFLRERLARYKVPRRVEFVDELPRTASGKIDRRALRERYAAG 448
|
|
| PRK07656 |
PRK07656 |
long-chain-fatty-acid--CoA ligase; Validated |
73-595 |
1.65e-130 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236072 [Multi-domain] Cd Length: 513 Bit Score: 392.35 E-value: 1.65e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 73 TVGQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQA----- 147
Cdd:PRK07656 6 TLPELLARAARRFGDKEAYV--FGDQRLTYAELNARVRRAAAALAALGIGKGDRVAIWAPNSPHWVIAALGALKAgavvv 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 148 --------MELEYVLKKVGCKALVFPKQFktqqyynvlkqiCPEVENAqpgalkSQRLPDLTTVISV-----DAPLPGTL 214
Cdd:PRK07656 84 plntrytaDEAAYILARGDAKALFVLGLF------------LGVDYSA------TTRLPALEHVVICeteedDPHTEKMK 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 215 LLDEVVAAGSTRQHLDQLQYNqqflschDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPN 294
Cdd:PRK07656 146 TFTDFLAAGDPAERAPEVDPD-------DVADILFTSGTTGRPKGAMLTHRQLLSNAADWAEYLGLTEGD----RYLAAN 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 295 PLYHCLGSVAGTMMCLMYGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPA 374
Cdd:PRK07656 215 PFFHVFGYKAGVNAPLMRGATILPL-PVFDPDEVFRLIETERITVLPGPPTMYNSLLQHPDRSAEDLSSLRLAVTGAASM 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 375 PPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYC 454
Cdd:PRK07656 294 PVALLERFESELGVDIVLTGYGLSEASGVTTFNRLDDDRKTVAGTIGTAIAGVENKIVN-ELGEEVPVGEVGELLVRGPN 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 455 VMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDR 534
Cdd:PRK07656 373 VMKGYYDDPEATAAAIDADGWLHTGDLGRLDEEGYLYIVDRKKDMFIVGGFNVYPAEVEEVLYEHPAVAEAAVIGVPDER 452
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 572879274 535 MGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:PRK07656 453 LGEVGKAYVVLKPGAELTEEELIAYCREHLAKYKVPRSIEFLDELPKNATGKVLKRALREK 513
|
|
| PRK06187 |
PRK06187 |
long-chain-fatty-acid--CoA ligase; Validated |
73-595 |
2.59e-122 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235730 [Multi-domain] Cd Length: 521 Bit Score: 371.44 E-value: 2.59e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 73 TVGQCLETTAQRVPEREALVVlhEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAqAM---- 148
Cdd:PRK06187 7 TIGRILRHGARKHPDKEAVYF--DGRRTTYAELDERVNRLANALRALGVKKGDRVAVFDWNSHEYLEAYFAVP-KIgavl 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 149 ----------ELEYVLKKVGCKALVFPKQFKtqqyynvlkqicPEVENAQPgalksqRLPDLTTVISV-DAPLPGT---- 213
Cdd:PRK06187 84 hpinirlkpeEIAYILNDAEDRVVLVDSEFV------------PLLAAILP------QLPTVRTVIVEgDGPAAPLapev 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 214 LLLDEVVAAGSTR---QHLDQlqynqqflscHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRM 290
Cdd:PRK06187 146 GEYEELLAAASDTfdfPDIDE----------NDAAAMLYTSGTTGHPKGVVLSHRNLFLHSLAVCAWLKLSRDD----VY 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 291 ILPNPLYHCLGSVAGtMMCLMYGATLILASPiFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIA 370
Cdd:PRK06187 212 LVIVPMFHVHAWGLP-YLALMAGAKQVIPRR-FDPENLLDLIETERVTFFFAVPTIWQMLLKAPRAYFVDFSSLRLVIYG 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 371 GSPAPPELIRAIINKINMkDLVVAYGTTENSP-VTFAHFPEDTVEQ--KAESVGRIMPHTEARIMNMEAGTLAK-LNTPG 446
Cdd:PRK06187 290 GAALPPALLREFKEKFGI-DLVQGYGMTETSPvVSVLPPEDQLPGQwtKRRSAGRPLPGVEARIVDDDGDELPPdGGEVG 368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 447 ELCIRGYCVMLGYWGEPQKTEEAVDQDkWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQ 526
Cdd:PRK06187 369 EIIVRGPWLMQGYWNRPEATAETIDGG-WLHTGDVGYIDEDGYLYITDRIKDVIISGGENIYPRELEDALYGHPAVAEVA 447
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 572879274 527 VVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:PRK06187 448 VIGVPDEKWGERPVAVVVLKPGATLDAKELRAFLRGRLAKFKLPKRIAFVDELPRTSVGKILKRVLREQ 516
|
|
| FC-FACS_FadD_like |
cd05936 |
Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This ... |
78-593 |
7.17e-117 |
|
Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; This subfamily of the AMP-forming adenylation family contains Escherichia coli FadD and similar prokaryotic fatty acid CoA synthetases. FadD was characterized as a long-chain fatty acid CoA synthetase. The gene fadD is regulated by the fatty acid regulatory protein FadR. Fatty acid CoA synthetase catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341259 [Multi-domain] Cd Length: 468 Bit Score: 355.72 E-value: 7.17e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVVLheDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQA---------- 147
Cdd:cd05936 5 LEEAARRFPDKTALIFM--GRKLTYRELDALAEAFAAGLQNLGVQPGDRVALMLPNCPQFPIAYFGALKAgavvvplnpl 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 148 ---MELEYVLKKVGCKALVFPKQFKTqqyynvlkqicpevenaqpgALKSQRLPDLTTVISVDAplpgtllldevVAAgs 224
Cdd:cd05936 83 ytpRELEHILNDSGAKALIVAVSFTD--------------------LLAAGAPLGERVALTPED-----------VAV-- 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 225 trqhldqlqynqqflschdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKlhEKTPEQLRMILPNPLYHCLGSVA 304
Cdd:cd05936 130 ----------------------LQYTSGTTGVPKGAMLTHRNLVANALQIKAWLE--DLLEGDDVVLAALPLFHVFGLTV 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 305 GTMMCLMYGATLILaSPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDIST---MCGGviaGSPAPPELIRA 381
Cdd:cd05936 186 ALLLPLALGATIVL-IPRFRPIGVLKEIRKHRVTIFPGVPTMYIALLNAPEFKKRDFSSlrlCISG---GAPLPVEVAER 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 382 IiNKINMKDLVVAYGTTENSPVTFAHFPEDtvEQKAESVGRIMPHTEARIMNMEaGTLAKLNTPGELCIRGYCVMLGYWG 461
Cdd:cd05936 262 F-EELTGVPIVEGYGLTETSPVVAVNPLDG--PRKPGSIGIPLPGTEVKIVDDD-GEELPPGEVGELWVRGPQVMKGYWN 337
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 462 EPQKTEEAVDqDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICA 541
Cdd:cd05936 338 RPEETAEAFV-DGWLRTGDIGYMDEDGYFFIVDRKKDMIIVGGFNVYPREVEEVLYEHPAVAEAAVVGVPDPYSGEAVKA 416
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 572879274 542 CIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 593
Cdd:cd05936 417 FVVLKEGASLTEEEIIAFCREQLAGYKVPRQVEFRDELPKSAVGKILRRELR 468
|
|
| AFD_class_I |
cd04433 |
Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as ... |
243-588 |
3.38e-115 |
|
Adenylate forming domain, Class I, also known as the ANL superfamily; This family is known as the ANL (acyl-CoA synthetases, the NRPS adenylation domains, and the Luciferase enzymes) superfamily. It includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases.The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.
Pssm-ID: 341228 [Multi-domain] Cd Length: 336 Bit Score: 346.58 E-value: 3.38e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 243 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHcLGSVAGTMMCLMYGATLILAsPI 322
Cdd:cd04433 1 DPALILYTSGTTGKPKGVVLSHRNLLAAAAALAASGGLTEGD----VFLSTLPLFH-IGGLFGLLGALLAGGTVVLL-PK 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 323 FNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGTTENSP 402
Cdd:cd04433 75 FDPEAALELIEREKVTILLGVPTLLARLLKAPESAGYDLSSLRALVSGGAPLPPELLERFEEAPGIK-LVNGYGLTETGG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 403 VTFAHFPEDtVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEaVDQDKWYWTGDVA 482
Cdd:cd04433 154 TVATGPPDD-DARKPGSVGRPVPGVEVRIVD-PDGGELPPGEIGELVVRGPSVMKGYWNNPEATAA-VDEDGWYRTGDLG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 483 TMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKG 562
Cdd:cd04433 231 RLDEDGYLYIVGRLKDMIKSGGENVYPAEVEAVLLGHPGVAEAAVVGVPDPEWGERVVAVVVLRPGADLDAEELRAHVRE 310
|
330 340
....*....|....*....|....*.
gi 572879274 563 KISHFKIPKYIVFVTNYPLTISGKIQ 588
Cdd:cd04433 311 RLAPYKVPRRVVFVDALPRTASGKID 336
|
|
| FACL_FadD13-like |
cd17631 |
fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, ... |
78-589 |
8.86e-115 |
|
fatty acyl-CoA synthetase, including FadD13; This family contains fatty acyl-CoA synthetases, including Mycobacterium tuberculosis acid-induced operon MymA encoding the fatty acyl-CoA synthetase FadD13 which is essential for virulence and intracellular growth of the pathogen. The fatty acyl-CoA synthetase activates lipids before entering into the metabolic pathways and is also involved in transmembrane lipid transport. However, unlike soluble fatty acyl-CoA synthetases, but like the mammalian integral-membrane very-long-chain acyl-CoA synthetases, FadD13 accepts lipid substrates up to the maximum length of C26, and this is facilitated by an extensive hydrophobic tunnel from the active site to a positively charged patch. Also included is feruloyl-CoA synthetase (Fcs) in Rhodococcus strains where it is involved in biotechnological vanillin production from eugenol and ferulic acid via a non-beta-oxidative pathway.
Pssm-ID: 341286 [Multi-domain] Cd Length: 435 Bit Score: 349.22 E-value: 8.86e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAqameleyvlkKV 157
Cdd:cd17631 1 LRRRARRHPDRTALV--FGGRSLTYAELDERVNRLAHALRALGVAKGDRVAVLSKNSPEFLELLFAAA----------RL 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 158 GCkalvfpkqfktqqyynvlkqicpevenaqpgalksqrlpdlttvisVDAPLPGTLLLDEVvaagstrqhLDQLQYNQQ 237
Cdd:cd17631 69 GA----------------------------------------------VFVPLNFRLTPPEV---------AYILADSGA 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 238 FLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCLGSVAGTMMCLMYGATLI 317
Cdd:cd17631 94 KVLFDDLALLMYTSGTTGRPKGAMLTHRNLLWNAVNALAALDLGPDD----VLLVVAPLFHIGGLGVFTLPTLLRGGTVV 169
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 318 LAsPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKInmKDLVVAYGT 397
Cdd:cd17631 170 IL-RKFDPETVLDLIERHRVTSFFLVPTMIQALLQHPRFATTDLSSLRAVIYGGAPMPERLLRALQARG--VKFVQGYGM 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 398 TENSPVTFAHFPEDTVEqKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVdQDKWYW 477
Cdd:cd17631 247 TETSPGVTFLSPEDHRR-KLGSAGRPVFFVEVRIVD-PDGREVPPGEVGEIVVRGPHVMAGYWNRPEATAAAF-RDGWFH 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 478 TGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIK 557
Cdd:cd17631 324 TGDLGRLDEDGYLYIVDRKKDMIISGGENVYPAEVEDVLYEHPAVAEVAVIGVPDEKWGEAVVAVVVPRPGAELDEDELI 403
|
490 500 510
....*....|....*....|....*....|..
gi 572879274 558 AFCKGKISHFKIPKYIVFVTNYPLTISGKIQK 589
Cdd:cd17631 404 AHCRERLARYKIPKSVEFVDALPRNATGKILK 435
|
|
| AMP-binding |
pfam00501 |
AMP-binding enzyme; |
78-503 |
3.85e-104 |
|
AMP-binding enzyme;
Pssm-ID: 459834 [Multi-domain] Cd Length: 417 Bit Score: 321.18 E-value: 3.85e-104
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVVlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQA---------- 147
Cdd:pfam00501 1 LERQAARTPDKTALEV-GEGRRLTYRELDERANRLAAGLRALGVGKGDRVAILLPNSPEWVVAFLACLKAgavyvplnpr 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 148 ---MELEYVLKKVGCKALVFPKQFKtqqyynvLKQICPevenaqpgALKSQRLPDLTTVISVDAPLPGTLLLDEVVAAgs 224
Cdd:pfam00501 80 lpaEELAYILEDSGAKVLITDDALK-------LEELLE--------ALGKLEVVKLVLVLDRDPVLKEEPLPEEAKPA-- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 225 trqhlDQLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMILPNPLYHCLGSVA 304
Cdd:pfam00501 143 -----DVPPPPPPPPDPDDLAYIIYTSGTTGKPKGVMLTHRNLVANVLSIKRVRPRGFGLGPDDRVLSTLPLFHDFGLSL 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 305 GTMMCLMYGATLILASPI--FNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAI 382
Cdd:pfam00501 218 GLLGPLLAGATVVLPPGFpaLDPAALLELIERYKVTVLYGVPTLLNMLLEAGAPKRALLSSLRLVLSGGAPLPPELARRF 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 383 iNKINMKDLVVAYGTTENSPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGE 462
Cdd:pfam00501 298 -RELFGGALVNGYGLTETTGVVTTPLPLDEDLRSLGSVGRPLPGTEVKIVDDETGEPVPPGEPGELCVRGPGVMKGYLND 376
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 572879274 463 PQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRG 503
Cdd:pfam00501 377 PELTAEAFDEDGWYRTGDLGRRDEDGYLEIVGRKKDQIKLG 417
|
|
| PRK08316 |
PRK08316 |
acyl-CoA synthetase; Validated |
70-598 |
2.24e-100 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 181381 [Multi-domain] Cd Length: 523 Bit Score: 314.95 E-value: 2.24e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 70 NSKTVGQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQA-- 147
Cdd:PRK08316 9 RRQTIGDILRRSARRYPDKTALV--FGDRSWTYAELDAAVNRVAAALLDLGLKKGDRVAALGHNSDAYALLWLACARAga 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 148 -------M----ELEYVLKKVGCKALVFPKQFktqqyynvlkqicpeVENAQPGALKSQRLPDLTTVISVDAPLPGTLL- 215
Cdd:PRK08316 87 vhvpvnfMltgeELAYILDHSGARAFLVDPAL---------------APTAEAALALLPVDTLILSLVLGGREAPGGWLd 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 216 LDEVVAAGSTRQHLDqlqynqqFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNN--SNILGERLKLHEktpeqlRMILP 293
Cdd:PRK08316 152 FADWAEAGSVAEPDV-------ELADDDLAQILYTSGTESLPKGAMLTHRALIAEyvSCIVAGDMSADD------IPLHA 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 294 NPLYHCLGSVAGTMMCLMYGAT-LILASPifNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGS 372
Cdd:PRK08316 219 LPLYHCAQLDVFLGPYLYVGATnVILDAP--DPELILRTIEAERITSFFAPPTVWISLLRHPDFDTRDLSSLRKGYYGAS 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 373 PAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVEqKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRG 452
Cdd:PRK08316 297 IMPVEVLKELRERLPGLRFYNCYGQTEIAPLATVLGPEEHLR-RPGSAGRPVLNVETRVVD-DDGNDVAPGEVGEIVHRS 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 453 YCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKD 532
Cdd:PRK08316 375 PQLMLGYWDDPEKTAEAF-RGGWFHSGDLGVMDEEGYITVVDRKKDMIKTGGENVASREVEEALYTHPAVAEVAVIGLPD 453
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 572879274 533 DRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMER 598
Cdd:PRK08316 454 PKWIEAVTAVVVPKAGATVTEDELIAHCRARLAGFKVPKRVIFVDELPRNPSGKILKRELRERYAG 519
|
|
| Firefly_Luc_like |
cd05911 |
Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family ... |
95-588 |
7.70e-94 |
|
Firefly luciferase of light emitting insects and 4-Coumarate-CoA Ligase (4CL); This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.
Pssm-ID: 341237 [Multi-domain] Cd Length: 486 Bit Score: 296.82 E-value: 7.70e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 95 HEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATA-------------QAMELEYVLKKVGCKA 161
Cdd:cd05911 6 DTGKELTYAQLRTLSRRLAAGLRKLGLKKGDVVGIISPNSTYYPPVFLGCLfaggifsaanpiyTADELAHQLKISKPKV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 162 LvfpkqFKTQQYYNVLKQICpevenaqpgalksQRLPDLTTVISVDAPLPGTLLLDEVVAAGSTRQhlDQLQYNQQFLSC 241
Cdd:cd05911 86 I-----FTDPDGLEKVKEAA-------------KELGPKDKIIVLDDKPDGVLSIEDLLSPTLGEE--DEDLPPPLKDGK 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 242 HDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEqlRMILPNPLYHCLGsVAGTMMCLMYGATLILaSP 321
Cdd:cd05911 146 DDTAAILYSSGTTGLPKGVCLSHRNLIANLSQVQTFLYGNDGSND--VILGFLPLYHIYG-LFTTLASLLNGATVII-MP 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 322 IFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENS 401
Cdd:cd05911 222 KFDSELFLDLIEKYKITFLYLVPPIAAALAKSPLLDKYDLSSLRVILSGGAPLSKELQELLAKRFPNATIKQGYGMTETG 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 402 PVTFaHFPEDTVeqKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDV 481
Cdd:cd05911 302 GILT-VNPDGDD--KPGSVGRLLPNVEAKIVDDDGKDSLGPNEPGEICVRGPQVMKGYYNNPEATKETFDEDGWLHTGDI 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 482 ATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCK 561
Cdd:cd05911 379 GYFDEDGYLYIVDRKKELIKYKGFQVAPAELEAVLLEHPGVADAAVIGIPDEVSGELPRAYVVRKPGEKLTEKEVKDYVA 458
|
490 500
....*....|....*....|....*...
gi 572879274 562 GKISHFK-IPKYIVFVTNYPLTISGKIQ 588
Cdd:cd05911 459 KKVASYKqLRGGVVFVDEIPKSASGKIL 486
|
|
| PRK13295 |
PRK13295 |
cyclohexanecarboxylate-CoA ligase; Reviewed |
46-596 |
1.83e-89 |
|
cyclohexanecarboxylate-CoA ligase; Reviewed
Pssm-ID: 171961 [Multi-domain] Cd Length: 547 Bit Score: 287.33 E-value: 1.83e-89
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 46 EVDRMVSTPIGGLSYVQGctkkHLNSKTVGQCLETTAQRVPEREALVVLHED----VRLTFAQLKEEVDKAASGLLSIGL 121
Cdd:PRK13295 2 EFDAVLLPPRRAASIAAG----HWHDRTINDDLDACVASCPDKTAVTAVRLGtgapRRFTYRELAALVDRVAVGLARLGV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 122 CKGDRLGMWGPNSYAWVLMQLATAQ-------AM------ELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEvenaq 188
Cdd:PRK13295 78 GRGDVVSCQLPNWWEFTVLYLACSRigavlnpLMpifrerELSFMLKHAESKVLVVPKTFRGFDHAAMARRLRPE----- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 189 pgalksqrLPDLTTVISVDAPLPGTLlldEVVAAGSTRqhlDQLQYNQQFLSCHDP-----INIQFTSGTTGSPKGATLS 263
Cdd:PRK13295 153 --------LPALRHVVVVGGDGADSF---EALLITPAW---EQEPDAPAILARLRPgpddvTQLIYTSGTTGEPKGVMHT 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 264 HYNIVNNSNILGERLKLhekTPEQLrMILPNPLYHCLGSVAGTMMCLMYGATLILASpIFNGKKALEAISRERGTFLYGT 343
Cdd:PRK13295 219 ANTLMANIVPYAERLGL---GADDV-ILMASPMAHQTGFMYGLMMPVMLGATAVLQD-IWDPARAAELIRTEGVTFTMAS 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 344 PTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGTTENSPVTFAHfPEDTVEQKAESVGRI 423
Cdd:PRK13295 294 TPFLTDLTRAVKESGRPVSSLRTFLCAGAPIPGALVERARAALGAK-IVSAWGMTENGAVTLTK-LDDPDERASTTDGCP 371
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 424 MPHTEARIMNmeaGTLAKL--NTPGELCIRGYCVMLGYWGEPQKTeeAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMII 501
Cdd:PRK13295 372 LPGVEVRVVD---ADGAPLpaGQIGRLQVRGCSNFGGYLKRPQLN--GTDADGWFDTGDLARIDADGYIRISGRSKDVII 446
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 502 RGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKG-KISHFKIPKYIVFVTNYP 580
Cdd:PRK13295 447 RGGENIPVVEIEALLYRHPAIAQVAIVAYPDERLGERACAFVVPRPGQSLDFEEMVEFLKAqKVAKQYIPERLVVRDALP 526
|
570
....*....|....*.
gi 572879274 581 LTISGKIQKFKLREQM 596
Cdd:PRK13295 527 RTPSGKIQKFRLREML 542
|
|
| FadD3 |
cd17638 |
acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ... |
243-589 |
3.91e-88 |
|
acyl-CoA synthetase FadD3 and similar proteins; This family contains long chain fatty acid CoA ligases, including FadD3 which is an acyl-CoA synthetase that initiates catabolism of cholesterol rings C and D in actinobacteria. The cholesterol catabolic pathway occurs in most mycolic acid-containing actinobacteria, such as Rhodococcus jostii RHA1, and is critical for Mycobacterium tuberculosis (Mtb) during infection. FadD3 catalyzes the ATP-dependent CoA thioesterification of 3a-alpha-H-4alpha(3'-propanoate)-7a-beta-methylhexahydro-1,5-indanedione (HIP) to yield HIP-CoA. Hydroxylated analogs of HIP, 5alpha-OH HIP and 1beta-OH HIP, can also be used.
Pssm-ID: 341293 [Multi-domain] Cd Length: 330 Bit Score: 276.69 E-value: 3.91e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 243 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCLGSVAGTMMCLMYGATlILASPI 322
Cdd:cd17638 1 DVSDIMFTSGTTGRSKGVMCAHRQTLRAAAAWADCADLTEDD----RYLIINPFFHTFGYKAGIVACLLTGAT-VVPVAV 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 323 FNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSP 402
Cdd:cd17638 76 FDVDAILEAIERERITVLPGPPTLFQSLLDHPGRKKFDLSSLRAAVTGAATVPVELVRRMRSELGFETVLTAYGLTEAGV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 403 VTFAHfPEDTVEQKAESVGRIMPHTEARIMNmeagtlaklntPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVA 482
Cdd:cd17638 156 ATMCR-PGDDAETVATTCGRACPGFEVRIAD-----------DGEVLVRGYNVMQGYLDDPEATAEAIDADGWLHTGDVG 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 483 TMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKG 562
Cdd:cd17638 224 ELDERGYLRITDRLKDMYIVGGFNVYPAEVEGALAEHPGVAQVAVIGVPDERMGEVGKAFVVARPGVTLTEEDVIAWCRE 303
|
330 340
....*....|....*....|....*..
gi 572879274 563 KISHFKIPKYIVFVTNYPLTISGKIQK 589
Cdd:cd17638 304 RLANYKVPRFVRFLDELPRNASGKVMK 330
|
|
| Acs |
COG0365 |
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism]; |
77-597 |
5.65e-87 |
|
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase [Lipid transport and metabolism];
Pssm-ID: 440134 [Multi-domain] Cd Length: 565 Bit Score: 281.23 E-value: 5.65e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 77 CLETTAQRVPEREALVVLHED---VRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQ------- 146
Cdd:COG0365 14 CLDRHAEGRGDKVALIWEGEDgeeRTLTYAELRREVNRFANALRALGVKKGDRVAIYLPNIPEAVIAMLACARigavhsp 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 147 ------AMELEYVLKKVGCKALVFpkqfkTQQYYNVLKQIC--PEVENAQpgalksQRLPDLTTVISV-----DAPLPGT 213
Cdd:COG0365 94 vfpgfgAEALADRIEDAEAKVLIT-----ADGGLRGGKVIDlkEKVDEAL------EELPSLEHVIVVgrtgaDVPMEGD 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 214 LLLDEVVAAGStrqhlDQLQYNQqfLSCHDPINIQFTSGTTGSPKGATLSHynivnnSNILGERLKLHektpeqlRMIL- 292
Cdd:COG0365 163 LDWDELLAAAS-----AEFEPEP--TDADDPLFILYTSGTTGKPKGVVHTH------GGYLVHAATTA-------KYVLd 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 293 --PNPLYHCLGSVaGTMMCLMY--------GATLIL--ASPIF-NGKKALEAISRERGTFLYGTPTMFVDILNQPDF--S 357
Cdd:COG0365 223 lkPGDVFWCTADI-GWATGHSYivygpllnGATVVLyeGRPDFpDPGRLWELIEKYGVTVFFTAPTAIRALMKAGDEplK 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 358 SYDIST--MCGGviAGSPAPPELIRAIINKINmKDLVVAYGTTEnspvTFAHF--PEDTVEQKAESVGRIMPHTEARIMN 433
Cdd:COG0365 302 KYDLSSlrLLGS--AGEPLNPEVWEWWYEAVG-VPIVDGWGQTE----TGGIFisNLPGLPVKPGSMGKPVPGYDVAVVD 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 434 mEAGTLAKLNTPGELCIRGYC--VMLGYWGEPQKTEEAV--DQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYP 509
Cdd:COG0365 375 -EDGNPVPPGEEGELVIKGPWpgMFRGYWNDPERYRETYfgRFPGWYRTGDGARRDEDGYFWILGRSDDVINVSGHRIGT 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 510 AELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDG---EETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGK 586
Cdd:COG0365 454 AEIESALVSHPAVAEAAVVGVPDEIRGQVVKAFVVLKPGvepSDELAKELQAHVREELGPYAYPREIEFVDELPKTRSGK 533
|
570
....*....|.
gi 572879274 587 IQKFKLREQME 597
Cdd:COG0365 534 IMRRLLRKIAE 544
|
|
| PRK06087 |
PRK06087 |
medium-chain fatty-acid--CoA ligase; |
72-600 |
1.23e-84 |
|
medium-chain fatty-acid--CoA ligase;
Pssm-ID: 180393 [Multi-domain] Cd Length: 547 Bit Score: 274.70 E-value: 1.23e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 72 KTVGQCLETTAQRVPEREAlVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQA---- 147
Cdd:PRK06087 23 ASLADYWQQTARAMPDKIA-VVDNHGASYTYSALDHAASRLANWLLAKGIEPGDRVAFQLPGWCEFTIIYLACLKVgavs 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 148 ---------MELEYVLKKVGCKALVFPKQFKTQQYynvLKQICPEVEnaqpgalksqRLPDLTTVISVD--APLPGTLLL 216
Cdd:PRK06087 102 vpllpswreAELVWVLNKCQAKMFFAPTLFKQTRP---VDLILPLQN----------QLPQLQQIVGVDklAPATSSLSL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 217 DEVVAAGSTRQHLDQLQYNQqfLSChdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQLrMILPNPL 296
Cdd:PRK06087 169 SQIIADYEPLTTAITTHGDE--LAA-----VLFTSGTEGLPKGVMLTHNNILASERAYCARLNL---TWQDV-FMMPAPL 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 297 YHCLGSVAGTMMCLMYGATLILASpIFNGKKALEAISRERGTFLYG-TPTMFvDILNQPDFSSYDISTM----CGGviag 371
Cdd:PRK06087 238 GHATGFLHGVTAPFLIGARSVLLD-IFTPDACLALLEQQRCTCMLGaTPFIY-DLLNLLEKQPADLSALrfflCGG---- 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 372 SPAPPELIRAIINKiNMKdLVVAYGTTENSPVTFAHfPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAkLNTPGELCIR 451
Cdd:PRK06087 312 TTIPKKVARECQQR-GIK-LLSVYGSTESSPHAVVN-LDDPLSRFMHTDGYAAAGVEIKVVDEARKTLP-PGCEGEEASR 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 452 GYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVK 531
Cdd:PRK06087 388 GPNVFMGYLDEPELTARALDEEGWYYSGDLCRMDEAGYIKITGRKKDIIVRGGENISSREVEDILLQHPKIHDACVVAMP 467
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 572879274 532 DDRMGEEICACIRLKDGEET-TVEEIKAF-CKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMERHL 600
Cdd:PRK06087 468 DERLGERSCAYVVLKAPHHSlTLEEVVAFfSRKRVAKYKYPEHIVVIDKLPRTASGKIQKFLLRKDIMRRL 538
|
|
| CHC_CoA_lg |
cd05903 |
Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); ... |
99-594 |
2.61e-84 |
|
Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Cyclohexanecarboxylate-CoA ligase activates the aliphatic ring compound, cyclohexanecarboxylate, for degradation. It catalyzes the synthesis of cyclohexanecarboxylate-CoA thioesters in a two-step reaction involving the formation of cyclohexanecarboxylate-AMP anhydride, followed by the nucleophilic substitution of AMP by CoA.
Pssm-ID: 341229 [Multi-domain] Cd Length: 437 Bit Score: 270.41 E-value: 2.61e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 99 RLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQA-------------MELEYVLKKVGCKALVFP 165
Cdd:cd05903 1 RLTYSELDTRADRLAAGLAALGVGPGDVVAFQLPNWWEFAVLYLACLRIgavtnpilpffreHELAFILRRAKAKVFVVP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 166 KQFKTQQYynvlkqicpevenaqpgalksqrlpdlttvisvdAPLPGtllldevvaagstrqhldqlqynqqflschDPI 245
Cdd:cd05903 81 ERFRQFDP----------------------------------AAMPD------------------------------AVA 96
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 246 NIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhektPEQLRMILPNPLYHCLGSVAGTMMCLMYGATLILASpIFNG 325
Cdd:cd05903 97 LLLFTSGTTGEPKGVMHSHNTLSASIRQYAERLGL----GPGDVFLVASPMAHQTGFVYGFTLPLLLGAPVVLQD-IWDP 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 326 KKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGTTENsPVTF 405
Cdd:cd05903 172 DKALALMREHGVTFMMGATPFLTDLLNAVEEAGEPLSRLRTFVCGGATVPRSLARRAAELLGAK-VCSAYGSTEC-PGAV 249
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 406 AHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAKlNTPGELCIRGYCVMLGYWGEPQKTEEAvDQDKWYWTGDVATMN 485
Cdd:cd05903 250 TSITPAPEDRRLYTDGRPLPGVEIKVVDDTGATLAP-GVEGELLSRGPSVFLGYLDRPDLTADA-APEGWFRTGDLARLD 327
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 486 EQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGK-I 564
Cdd:cd05903 328 EDGYLRITGRSKDIIIRGGENIPVLEVEDLLLGHPGVIEAAVVALPDERLGERACAVVVTKSGALLTFDELVAYLDRQgV 407
|
490 500 510
....*....|....*....|....*....|
gi 572879274 565 SHFKIPKYIVFVTNYPLTISGKIQKFKLRE 594
Cdd:cd05903 408 AKQYWPERLVHVDDLPRTPSGKVQKFRLRE 437
|
|
| PRK06710 |
PRK06710 |
long-chain-fatty-acid--CoA ligase; Validated |
78-598 |
2.82e-79 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 180666 [Multi-domain] Cd Length: 563 Bit Score: 261.12 E-value: 2.82e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVVLHEDVrlTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQA---------- 147
Cdd:PRK06710 30 VEQMASRYPEKKALHFLGKDI--TFSVFHDKVKRFANYLQKLGVEKGDRVAIMLPNCPQAVIGYYGTLLAggivvqtnpl 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 148 ---MELEYVLKKVGCKALVfpkqfktqqyynVLKQICPEVENAQpGALKSQRLpdLTTVISVDAPLPGTLLLDEVVAAGS 224
Cdd:PRK06710 108 yteRELEYQLHDSGAKVIL------------CLDLVFPRVTNVQ-SATKIEHV--IVTRIADFLPFPKNLLYPFVQKKQS 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 225 ------TRQHLDQL------QYNQQFLSCHDPIN----IQFTSGTTGSPKGATLSHYNIVNNSnILGERLKLHEKTPEQL 288
Cdd:PRK06710 173 nlvvkvSESETIHLwnsvekEVNTGVEVPCDPENdlalLQYTGGTTGFPKGVMLTHKNLVSNT-LMGVQWLYNCKEGEEV 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 289 RM-ILPnpLYHCLGSVAGTMMCLMYGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGG 367
Cdd:PRK06710 252 VLgVLP--FFHVYGMTAVMNLSIMQGYKMVLI-PKFDMKMVFEAIKKHKVTLFPGAPTIYIALLNSPLLKEYDISSIRAC 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 368 VIAGSPAPPElIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDtvEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGE 447
Cdd:PRK06710 329 ISGSAPLPVE-VQEKFETVTGGKLVEGYGLTESSPVTHSNFLWE--KRVPGSIGVPWPDTEAMIMSLETGEALPPGEIGE 405
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 448 LCIRGYCVMLGYWGEPQKTEeAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQV 527
Cdd:PRK06710 406 IVVKGPQIMKGYWNKPEETA-AVLQDGWLHTGDVGYMDEDGFFYVKDRKKDMIVASGFNVYPREVEEVLYEHEKVQEVVT 484
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 572879274 528 VGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMER 598
Cdd:PRK06710 485 IGVPDPYRGETVKAFVVLKEGTECSEEELNQFARKYLAAYKVPKVYEFRDELPKTTVGKILRRVLIEEEKR 555
|
|
| PRK06839 |
PRK06839 |
o-succinylbenzoate--CoA ligase; |
78-595 |
4.13e-78 |
|
o-succinylbenzoate--CoA ligase;
Pssm-ID: 168698 [Multi-domain] Cd Length: 496 Bit Score: 255.94 E-value: 4.13e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVVLHEDvrLTFAQLKEEVDKAASGLL-SIGLCKGDRLGMWGPNSYAWVLMQLATAqameleyvlkK 156
Cdd:PRK06839 8 IEKRAYLHPDRIAIITEEEE--MTYKQLHEYVSKVAAYLIyELNVKKGERIAILSQNSLEYIVLLFAIA----------K 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 157 VGCKALVF-----PKQFKTQQYYNVLKQICPEVENAQPGALksqrlpdLTTVISVDAPLPGTLLldevvaAGSTRQHLDQ 231
Cdd:PRK06839 76 VECIAVPLnirltENELIFQLKDSGTTVLFVEKTFQNMALS-------MQKVSYVQRVISITSL------KEIEDRKIDN 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 232 LQYNQQflscHDPINIQFTSGTTGSPKGATLSHYNIVNNS--NILGERLKLHEktpeqlRMILPNPLYHCLGSVAGTMMC 309
Cdd:PRK06839 143 FVEKNE----SASFIICYTSGTTGKPKGAVLTQENMFWNAlnNTFAIDLTMHD------RSIVLLPLFHIGGIGLFAFPT 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 310 LMYGATLILASPiFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMk 389
Cdd:PRK06839 213 LFAGGVIIVPRK-FEPTKALSMIEKHKVTVVMGVPTIHQALINCSKFETTNLQSVRWFYNGGAPCPEELMREFIDRGFL- 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 390 dLVVAYGTTENSPVTFAhFPEDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEA 469
Cdd:PRK06839 291 -FGQGFGMTETSPTVFM-LSEEDARRKVGSIGKPVLFCDYELID-ENKNKVEVGEVGELLIRGPNVMKEYWNRPDATEET 367
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 470 VdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGE 549
Cdd:PRK06839 368 I-QDGWLCTGDLARVDEDGFVYIVGRKKEMIISGGENIYPLEVEQVINKLSDVYEVAVVGRQHVKWGEIPIAFIVKKSSS 446
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 572879274 550 ETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:PRK06839 447 VLIEKDVIEHCRLFLAKYKIPKEIVFLKELPKNATGKIQKAQLVNQ 492
|
|
| FACL_DitJ_like |
cd05934 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
99-593 |
1.47e-77 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Members of this family include DitJ from Pseudomonas and similar proteins.
Pssm-ID: 341257 [Multi-domain] Cd Length: 422 Bit Score: 252.21 E-value: 1.47e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 99 RLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLA-------------TAQAMELEYVLKKVGCKALVFp 165
Cdd:cd05934 3 RWTYAELLRESARIAAALAALGIRPGDRVALMLDNCPEFLFAWFAlaklgavlvpintALRGDELAYIIDHSGAQLVVV- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 166 kqfktqqyynvlkqicpevenaqpgalksqrlpdlttvisvdaplpgtllldevvaagstrqhldqlqynqqflschDPI 245
Cdd:cd05934 82 -----------------------------------------------------------------------------DPA 84
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 246 NIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCLGSVAGTMMCLMYGATLILAsPIFNG 325
Cdd:cd05934 85 SILYTSGTTGPPKGVVITHANLTFAGYYSARRFGLGEDD----VYLTVLPLFHINAQAVSVLAALSVGATLVLL-PRFSA 159
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 326 KKALEAISRERGTFLYGTPTMFVDILNQPDfsSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGTTENSPVTF 405
Cdd:cd05934 160 SRFWSDVRRYGATVTNYLGAMLSYLLAQPP--SPDDRAHRLRAAYGAPNPPELHEEFEERFGVR-LLEGYGMTETIVGVI 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 406 AHFPEDTveqKAESVGRIMPHTEARIMNMEAGTLAKlNTPGELCIR---GYCVMLGYWGEPQKTEEAVdQDKWYWTGDVA 482
Cdd:cd05934 237 GPRDEPR---RPGSIGRPAPGYEVRIVDDDGQELPA-GEPGELVIRglrGWGFFKGYYNMPEATAEAM-RNGWFHTGDLG 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 483 TMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKG 562
Cdd:cd05934 312 YRDADGFFYFVDRKKDMIRRRGENISSAEVERAILRHPAVREAAVVAVPDEVGEDEVKAVVVLRPGETLDPEELFAFCEG 391
|
490 500 510
....*....|....*....|....*....|.
gi 572879274 563 KISHFKIPKYIVFVTNYPLTISGKIQKFKLR 593
Cdd:cd05934 392 QLAYFKVPRYIRFVDDLPKTPTEKVAKAQLR 422
|
|
| ttLC_FACS_AlkK_like |
cd12119 |
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ... |
78-594 |
2.51e-76 |
|
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family catalyzes the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified from Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes uncharacterized FACS proteins.
Pssm-ID: 341284 [Multi-domain] Cd Length: 518 Bit Score: 251.78 E-value: 2.51e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVVLHED--VRLTFAQLKEEVDKAASGLLSIGLCKGDRLG--MWgpNS-------YAWVLM--QLAT 144
Cdd:cd12119 2 LEHAARLHGDREIVSRTHEGevHRYTYAEVAERARRLANALRRLGVKPGDRVAtlAW--NThrhlelyYAVPGMgaVLHT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 145 AQ----AMELEYVLKKVGCKALVFPKQFKtqqyynvlkqicPEVENAQPgalksqRLPDLTTVI----SVDAPLPGTLLL 216
Cdd:cd12119 80 INprlfPEQIAYIINHAEDRVVFVDRDFL------------PLLEAIAP------RLPTVEHVVvmtdDAAMPEPAGVGV 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 217 ---DEVVAAGSTRQHLDQLQYNqqflschDPINIQFTSGTTGSPKGATLSHYNIV------NNSNILGErlklhektpEQ 287
Cdd:cd12119 142 layEELLAAESPEYDWPDFDEN-------TAAAICYTSGTTGNPKGVVYSHRSLVlhamaaLLTDGLGL---------SE 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 288 LRMILP-NPLYHCLGsvAGT-MMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMC 365
Cdd:cd12119 206 SDVVLPvVPMFHVNA--WGLpYAAAMVGAKLVLPGPYLDPASLAELIEREGVTFAAGVPTVWQGLLDHLEANGRDLSSLR 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 366 GGVIAGSPAPPELIRAIINKInmKDLVVAYGTTENSPV-TFAHFP----EDTVEQKAE---SVGRIMPHTEARIMNMEAG 437
Cdd:cd12119 284 RVVIGGSAVPRSLIEAFEERG--VRVIHAWGMTETSPLgTVARPPsehsNLSEDEQLAlraKQGRPVPGVELRIVDDDGR 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 438 TLAKL-NTPGELCIRGYCVMLGYWGEPQKTEEaVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFF 516
Cdd:cd12119 362 ELPWDgKAVGELQVRGPWVTKSYYKNDEESEA-LTEDGWLRTGDVATIDEDGYLTITDRSKDVIKSGGEWISSVELENAI 440
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 572879274 517 HTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 594
Cdd:cd12119 441 MAHPAVAEAAVIGVPHPKWGERPLAVVVLKEGATVTAEELLEFLADKVAKWWLPDDVVFVDEIPKTSTGKIDKKALRE 518
|
|
| ttLC_FACS_AEE21_like |
cd12118 |
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This ... |
78-594 |
6.81e-76 |
|
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; This family includes fatty acyl-CoA synthetases that can activate medium to long-chain fatty acids. These enzymes catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid. Also included in this family are acyl activating enzymes from Arabidopsis, which contains a large number of proteins from this family with up to 63 different genes, many of which are uncharacterized.
Pssm-ID: 341283 [Multi-domain] Cd Length: 486 Bit Score: 249.52 E-value: 6.81e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQA---------- 147
Cdd:cd12118 10 LERAAAVYPDRTSIV--YGDRRYTWRQTYDRCRRLASALAALGISRGDTVAVLAPNTPAMYELHFGVPMAgavlnalntr 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 148 ---MELEYVLKKVGCKALVFPKQFktqQYYNVLKQICPEVENAQPgalksqrlpdlttvisvdaplpgtllLDEvvaags 224
Cdd:cd12118 88 ldaEEIAFILRHSEAKVLFVDREF---EYEDLLAEGDPDFEWIPP--------------------------ADE------ 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 225 trqhldqlqynqqflscHDPINIQFTSGTTGSPKGATLSHYNIVNN--SNILGERLKLHEktpeqlRMILPNPLYHCLG- 301
Cdd:cd12118 133 -----------------WDPIALNYTSGTTGRPKGVVYHHRGAYLNalANILEWEMKQHP------VYLWTLPMFHCNGw 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 302 -------SVAGTMMCLmygatlilasPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPA 374
Cdd:cd12118 190 cfpwtvaAVGGTNVCL----------RKVDAKAIYDLIEKHKVTHFCGAPTVLNMLANAPPSDARPLPHRVHVMTAGAPP 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 375 PPelirAIINKINMKDLVV--AYGTTENS-PVTFAHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAKLNTP------ 445
Cdd:cd12118 260 PA----AVLAKMEELGFDVthVYGLTETYgPATVCAWKPEWDELPTEERARLKARQGVRYVGLEEVDVLDPETMkpvprd 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 446 ----GELCIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPK 521
Cdd:cd12118 336 gktiGEIVFRGNIVMKGYLKNPEATAEAF-RGGWFHSGDLAVIHPDGYIEIKDRSKDIIISGGENISSVEVEGVLYKHPA 414
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 572879274 522 VQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVtNYPLTISGKIQKFKLRE 594
Cdd:cd12118 415 VLEAAVVARPDEKWGEVPCAFVELKEGAKVTEEEIIAFCREHLAGFMVPKTVVFG-ELPKTSTGKIQKFVLRD 486
|
|
| PRK06188 |
PRK06188 |
acyl-CoA synthetase; Validated |
73-595 |
1.18e-74 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235731 [Multi-domain] Cd Length: 524 Bit Score: 247.59 E-value: 1.18e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 73 TVGQCLETTAQRVPEREALVVlhEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSyAWVLMQLATAQAMELE- 151
Cdd:PRK06188 13 TYGHLLVSALKRYPDRPALVL--GDTRLTYGQLADRISRYIQAFEALGLGTGDAVALLSLNR-PEVLMAIGAAQLAGLRr 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 152 -------------YVLKKVGCKALVF-PKQFktqqyynvlkqicpeVENAqpGALKsQRLPDLTTVISVDAPLPGTLLLD 217
Cdd:PRK06188 90 talhplgslddhaYVLEDAGISTLIVdPAPF---------------VERA--LALL-ARVPSLKHVLTLGPVPDGVDLLA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 218 EVVAAGSTRQHLDQLQynqqflscHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhektPEQLRMILPNPLY 297
Cdd:PRK06188 152 AAAKFGPAPLVAAALP--------PDIAGLAYTGGTTGKPKGVMGTHRSIATMAQIQLAEWEW----PADPRFLMCTPLS 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 298 HclgsVAGTMM--CLMYGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAP 375
Cdd:PRK06188 220 H----AGGAFFlpTLLRGGTVIVL-AKFDPAEVLRAIEEQRITATFLVPTMIYALLDHPDLRTRDLSSLETVYYGASPMS 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 376 PELIRAIINKINmKDLVVAYGTTE-NSPVTF----AHFPEDtvEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCI 450
Cdd:PRK06188 295 PVRLAEAIERFG-PIFAQYYGQTEaPMVITYlrkrDHDPDD--PKRLTSCGRPTPGLRVALLD-EDGREVAQGEVGEICV 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 451 RGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGV 530
Cdd:PRK06188 371 RGPLVMDGYWNRPEETAEAF-RDGWLHTGDVAREDEDGFYYIVDRKKDMIVTGGFNVFPREVEDVLAEHPAVAQVAVIGV 449
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 572879274 531 KDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:PRK06188 450 PDEKWGEAVTAVVVLRPGAAVDAAELQAHVKERKGSVHAPKQVDFVDSLPLTALGKPDKKALRAR 514
|
|
| EntE |
COG1021 |
EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase ... |
72-598 |
1.03e-73 |
|
EntE, 2,3-dihydroxybenzoate-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440644 [Multi-domain] Cd Length: 533 Bit Score: 245.44 E-value: 1.03e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 72 KTVGQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDR----LgmwgPNSY------------ 135
Cdd:COG1021 25 ETLGDLLRRRAERHPDRIAVV--DGERRLSYAELDRRADRLAAGLLALGLRPGDRvvvqL----PNVAefvivffalfra 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 136 -AWVLMQLATAQAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICpevenaqpgalksQRLPDLTTVISVDAPLPGTL 214
Cdd:COG1021 99 gAIPVFALPAHRRAEISHFAEQSEAVAYIIPDRHRGFDYRALARELQ-------------AEVPSLRHVLVVGDAGEFTS 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 215 LlDEVVAAGStrqhlDQLQYNqqfLSCHDPINIQFTSGTTGSPKGATLSH----YNIVNNSNILGerlkLHEKTpeqlRM 290
Cdd:COG1021 166 L-DALLAAPA-----DLSEPR---PDPDDVAFFQLSGGTTGLPKLIPRTHddylYSVRASAEICG----LDADT----VY 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 291 --ILP---N-PLyhclgSVAGTMMCLMYGATLILA---SPifngKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDI 361
Cdd:COG1021 229 laALPaahNfPL-----SSPGVLGVLYAGGTVVLApdpSP----DTAFPLIERERVTVTALVPPLALLWLDAAERSRYDL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 362 STMcgGVI--AGSPAPPELIRAIINKINMKdLVVAYGTTEnSPVTFAHfPEDTVEQKAESVGR-IMPHTEARIMNmEAGT 438
Cdd:COG1021 300 SSL--RVLqvGGAKLSPELARRVRPALGCT-LQQVFGMAE-GLVNYTR-LDDPEEVILTTQGRpISPDDEVRIVD-EDGN 373
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 439 LAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHT 518
Cdd:COG1021 374 PVPPGEVGELLTRGPYTIRGYYRAPEHNARAFTPDGFYRTGDLVRRTPDGYLVVEGRAKDQINRGGEKIAAEEVENLLLA 453
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 519 HPKVQEVQVVGVKDDRMGEEICACIRLkDGEETTVEEIKAFCKGK-ISHFKIPKYIVFVTNYPLTISGKIQKFKLREQME 597
Cdd:COG1021 454 HPAVHDAAVVAMPDEYLGERSCAFVVP-RGEPLTLAELRRFLRERgLAAFKLPDRLEFVDALPLTAVGKIDKKALRAALA 532
|
.
gi 572879274 598 R 598
Cdd:COG1021 533 A 533
|
|
| 4CL |
cd05904 |
4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the ... |
82-595 |
6.15e-73 |
|
4-Coumarate-CoA Ligase (4CL); 4-Coumarate:coenzyme A ligase is a key enzyme in the phenylpropanoid metabolic pathway for monolignol and flavonoid biosynthesis. It catalyzes the synthesis of hydroxycinnamate-CoA thioesters in a two-step reaction, involving the formation of hydroxycinnamate-AMP anhydride and the nucleophilic substitution of AMP by CoA. The phenylpropanoid pathway is one of the most important secondary metabolism pathways in plants and hydroxycinnamate-CoA thioesters are the precursors of lignin and other important phenylpropanoids.
Pssm-ID: 341230 [Multi-domain] Cd Length: 505 Bit Score: 242.53 E-value: 6.15e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 82 AQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLAtaqAMELEYVLKKVgcka 161
Cdd:cd05904 15 ASAHPSRPALIDAATGRALTYAELERRVRRLAAGLAKRGGRKGDVVLLLSPNSIEFPVAFLA---VLSLGAVVTTA---- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 162 lvfpKQFKTQQyyNVLKQicpeVENAQPGALKSQ-----RLPDL-TTVISVDAPlpgtlllDEVVAAGSTRQHL-DQLQY 234
Cdd:cd05904 88 ----NPLSTPA--EIAKQ----VKDSGAKLAFTTaelaeKLASLaLPVVLLDSA-------EFDSLSFSDLLFEaDEAEP 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 235 NQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILgERLKLHEKTPEQlRMILPNPLYHCLGSVAGTMMCLMYGA 314
Cdd:cd05904 151 PVVVIKQDDVAALLYSSGTTGRSKGVMLTHRNLIAMVAQF-VAGEGSNSDSED-VFLCVLPMFHIYGLSSFALGLLRLGA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 315 TlILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVA 394
Cdd:cd05904 229 T-VVVMPRFDLEELLAAIERYKVTHLPVVPPIVLALVKSPIVDKYDLSSLRQIMSGAAPLGKELIEAFRAKFPNVDLGQG 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 395 YGTTENSPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDK 474
Cdd:cd05904 308 YGMTESTGVVAMCFAPEKDRAKYGSVGRLVPNVEAKIVDPETGESLPPNQTGELWIRGPSIMKGYLNNPEATAATIDKEG 387
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 475 WYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVE 554
Cdd:cd05904 388 WLHTGDLCYIDEDGYLFIVDRLKELIKYKGFQVAPAELEALLLSHPEILDAAVIPYPDEEAGEVPMAFVVRKPGSSLTED 467
|
490 500 510 520
....*....|....*....|....*....|....*....|.
gi 572879274 555 EIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIqkfkLREQ 595
Cdd:cd05904 468 EIMDFVAKQVAPYKKVRKVAFVDAIPKSPSGKI----LRKE 504
|
|
| FACL_fum10p_like |
cd05926 |
Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL ... |
86-594 |
8.12e-72 |
|
Subfamily of fatty acid CoA ligase (FACL) similar to Fum10p of Gibberella moniliformis; FACL catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, followed by the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Fum10p is a fatty acid CoA ligase involved in the synthesis of fumonisin, a polyketide mycotoxin, in Gibberella moniliformis.
Pssm-ID: 341249 [Multi-domain] Cd Length: 493 Bit Score: 239.14 E-value: 8.12e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 86 PEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATA-------------QAMELEY 152
Cdd:cd05926 1 PDAPALVVPGSTPALTYADLAELVDDLARQLAALGIKKGDRVAIALPNGLEFVVAFLAAAragavvaplnpayKKAEFEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 153 VLKKVGCKALVFPKQFKTqqyynvlkqicPEVENAQ--PGALKSQRLPDLTTVISVDAPLPGTLLLDEVVAAGSTRQHLD 230
Cdd:cd05926 81 YLADLGSKLVLTPKGELG-----------PASRAASklGLAILELALDVGVLIRAPSAESLSNLLADKKNAKSEGVPLPD 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 231 qlqynqqflschDPINIQFTSGTTGSPKGATLSHYNIVNNS-NILGErlklHEKTPEQlRMILPNPLYHCLGSVAGTMMC 309
Cdd:cd05926 150 ------------DLALILHTSGTTGRPKGVPLTHRNLAASAtNITNT----YKLTPDD-RTLVVMPLFHVHGLVASLLST 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 310 LMYGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYD-------ISTmcggviAGSPAPPELIRAI 382
Cdd:cd05926 213 LAAGGSVVLP-PRFSASTFWPDVRDYNATWYTAVPTIHQILLNRPEPNPESpppklrfIRS------CSASLPPAVLEAL 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 383 INKINMKdLVVAYGTTENSPVTFAHfPEDTVEQKAESVGRimPH-TEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWG 461
Cdd:cd05926 286 EATFGAP-VLEAYGMTEAAHQMTSN-PLPPGPRKPGSVGK--PVgVEVRILD-EDGEILPPGVVGEICLRGPNVTRGYLN 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 462 EPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICA 541
Cdd:cd05926 361 NPEANAEAAFKDGWFRTGDLGYLDADGYLFLTGRIKELINRGGEKISPLEVDGVLLSHPAVLEAVAFGVPDEKYGEEVAA 440
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 572879274 542 CIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 594
Cdd:cd05926 441 AVVLREGASVTEEELRAFCRKHLAAFKVPKKVYFVDELPKTATGKIQRRKVAE 493
|
|
| PRK05605 |
PRK05605 |
long-chain-fatty-acid--CoA ligase; Validated |
78-598 |
3.90e-71 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235531 [Multi-domain] Cd Length: 573 Bit Score: 239.52 E-value: 3.90e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVVLHEdvRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNS-------YAwVLMQLATA----- 145
Cdd:PRK05605 38 YDNAVARFGDRPALDFFGA--TTTYAELGKQVRRAAAGLRALGVRPGDRVAIVLPNCpqhivafYA-VLRLGAVVvehnp 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 146 --QAMELEYVLKKVGCK-ALVFPKqfktqqyynvlkqICPEVEnaqpgalksqRLPD---LTTVISVD------------ 207
Cdd:PRK05605 115 lyTAHELEHPFEDHGARvAIVWDK-------------VAPTVE----------RLRRttpLETIVSVNmiaampllqrla 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 208 ----------------APLPGTLLLDEVVAAGSTrqhLDQLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVnnS 271
Cdd:PRK05605 172 lrlpipalrkaraaltGPAPGTVPWETLVDAAIG---GDGSDVSHPRPTPDDVALILYTSGTTGKPKGAQLTHRNLF--A 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 272 NILGERLKLHEKTPEQLRMILPNPLYHCLGSVAGTMMCLMYGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDIL 351
Cdd:PRK05605 247 NAAQGKAWVPGLGDGPERVLAALPMFHAYGLTLCLTLAVSIGGELVLL-PAPDIDLILDAMKKHPPTWLPGVPPLYEKIA 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 352 NQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGTTENSPVTFAHFPEDTveQKAESVGRIMPHTEARI 431
Cdd:PRK05605 326 EAAEERGVDLSGVRNAFSGAMALPVSTVELWEKLTGGL-LVEGYGLTETSPIIVGNPMSDD--RRPGYVGVPFPDTEVRI 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 432 MNME--AGTLAKlNTPGELCIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYP 509
Cdd:PRK05605 403 VDPEdpDETMPD-GEEGELLVRGPQVFKGYWNRPEETAKSF-LDGWFRTGDVVVMEEDGFIRIVDRIKELIITGGFNVYP 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 510 AELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQK 589
Cdd:PRK05605 481 AEVEEVLREHPGVEDAAVVGLPREDGSEEVVAAVVLEPGAALDPEGLRAYCREHLTRYKVPRRFYHVDELPRDQLGKVRR 560
|
....*....
gi 572879274 590 FKLREQMER 598
Cdd:PRK05605 561 REVREELLE 569
|
|
| FAA1 |
COG1022 |
Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism]; |
72-534 |
3.59e-70 |
|
Long-chain acyl-CoA synthetase (AMP-forming) [Lipid transport and metabolism];
Pssm-ID: 440645 [Multi-domain] Cd Length: 603 Bit Score: 237.69 E-value: 3.59e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 72 KTVGQCLETTAQRVPEREALVVLHED--VRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLA------ 143
Cdd:COG1022 11 DTLPDLLRRRAARFPDRVALREKEDGiwQSLTWAEFAERVRALAAGLLALGVKPGDRVAILSDNRPEWVIADLAilaaga 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 144 -------TAQAMELEYVLKKVGCKALVFpkqfKTQQYYNVLKQICPEvenaqpgalksqrLPDLTTVISVDAP----LPG 212
Cdd:COG1022 91 vtvpiypTSSAEEVAYILNDSGAKVLFV----EDQEQLDKLLEVRDE-------------LPSLRHIVVLDPRglrdDPR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 213 TLLLDEVVAAGSTRQHLDQLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpEQLrMIL 292
Cdd:COG1022 154 LLSLDELLALGREVADPAELEARRAAVKPDDLATIIYTSGTTGRPKGVMLTHRNLLSNARALLERLPLGPGD-RTL-SFL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 293 PnpLYHCLGSVAGtMMCLMYGA--------------------TLILASP-----------------------IFN----- 324
Cdd:COG1022 232 P--LAHVFERTVS-YYALAAGAtvafaespdtlaedlrevkpTFMLAVPrvwekvyagiqakaeeagglkrkLFRwalav 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 325 GKKALEAISRERG-TFLYGTPTMFVDILNqpdFSSydISTMCGG-----VIAGSPAPPELIR---AI-INkinmkdLVVA 394
Cdd:COG1022 309 GRRYARARLAGKSpSLLLRLKHALADKLV---FSK--LREALGGrlrfaVSGGAALGPELARffrALgIP------VLEG 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 395 YGTTENSPVTFAHFPEDtveQKAESVGRIMPHTEARImnmeagtlaklNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDK 474
Cdd:COG1022 378 YGLTETSPVITVNRPGD---NRIGTVGPPLPGVEVKI-----------AEDGEILVRGPNVMKGYYKNPEATAEAFDADG 443
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 572879274 475 WYWTGDVATMNEQGFCKIVGRSKDMII-RGGENIYPAELEDFFHTHPKVQEVQVVGvkDDR 534
Cdd:COG1022 444 WLHTGDIGELDEDGFLRITGRKKDLIVtSGGKNVAPQPIENALKASPLIEQAVVVG--DGR 502
|
|
| PRK06145 |
PRK06145 |
acyl-CoA synthetase; Validated |
82-597 |
1.32e-68 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 102207 [Multi-domain] Cd Length: 497 Bit Score: 230.93 E-value: 1.32e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 82 AQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAM------------- 148
Cdd:PRK06145 12 ARRTPDRAALV--YRDQEISYAEFHQRILQAAGMLHARGIGQGDVVALLMKNSAAFLELAFAASYLGavflpinyrlaad 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 149 ELEYVLKKVGCKALVFPKQFktqqyynvlkqicpeveNAQPGALKSQrlpdlttvisvdaplpgtLLLDEVVAAGSTRQH 228
Cdd:PRK06145 90 EVAYILGDAGAKLLLVDEEF-----------------DAIVALETPK------------------IVIDAAAQADSRRLA 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 229 LDQLQYNQQFLSC-HDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCLGSVAGTM 307
Cdd:PRK06145 135 QGGLEIPPQAAVApTDLVRLMYTSGTTDRPKGVMHSYGNLHWKSIDHVIALGLTASE----RLLVVGPLYHVGAFDLPGI 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 308 MCLMYGATLILASPiFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKIN 387
Cdd:PRK06145 211 AVLWVGGTLRIHRE-FDPEAVLAAIERHRLTCAWMAPVMLSRVLTVPDRDRFDLDSLAWCIGGGEKTPESRIRDFTRVFT 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 388 MKDLVVAYGTTENspVTFAHFPEDTVE-QKAESVGRIMPHTEARIMNMEAGTLAKlNTPGELCIRGYCVMLGYWGEPQKT 466
Cdd:PRK06145 290 RARYIDAYGLTET--CSGDTLMEAGREiEKIGSTGRALAHVEIRIADGAGRWLPP-NMKGEICMRGPKVTKGYWKDPEKT 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 467 EEAVDQDkWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLK 546
Cdd:PRK06145 367 AEAFYGD-WFRSGDVGYLDEEGFLYLTDRKKDMIISGGENIASSEVERVIYELPEVAEAAVIGVHDDRWGERITAVVVLN 445
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 572879274 547 DGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQME 597
Cdd:PRK06145 446 PGATLTLEALDRHCRQRLASFKVPRQLKVRDELPRNPSGKVLKRVLRDELN 496
|
|
| PRK08314 |
PRK08314 |
long-chain-fatty-acid--CoA ligase; Validated |
78-595 |
2.13e-68 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236235 [Multi-domain] Cd Length: 546 Bit Score: 231.39 E-value: 2.13e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAAsGLLS--IGLCKGDRLGMWGPNSYAWVLMQLATAQA-------- 147
Cdd:PRK08314 16 LEVSARRYPDKTAIV--FYGRAISYRELLEEAERLA-GYLQqeCGVRKGDRVLLYMQNSPQFVIAYYAILRAnavvvpvn 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 148 -M----ELEYVLKKVGCKALVFpkqfkTQQYYNVLKQICPEVENAQ------PGALKSQ---RLPDLttvISVDAPLP-- 211
Cdd:PRK08314 93 pMnreeELAHYVTDSGARVAIV-----GSELAPKVAPAVGNLRLRHvivaqySDYLPAEpeiAVPAW---LRAEPPLQal 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 212 ---GTLLLDEVVAAGST----RQHLDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYNIvnNSNILGERLkLHEKT 284
Cdd:PRK08314 165 apgGVVAWKEALAAGLAppphTAGPDDLAV------------LPYTSGTTGVPKGCMHTHRTV--MANAVGSVL-WSNST 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 285 PEQLrMILPNPLYHCLGSVAGTMMCLMYGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTM 364
Cdd:PRK08314 230 PESV-VLAVLPLFHVTGMVHSMNAPIYAGATVVLM-PRWDREAAARLIERYRVTHWTNIPTMVVDFLASPGLAERDLSSL 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 365 CggVIAGSPAP-PElirAIINKinMKDL-----VVAYGTTENspVTFAHF-PEDtvEQKAESVGriMPH--TEARIMNME 435
Cdd:PRK08314 308 R--YIGGGGAAmPE---AVAER--LKELtgldyVEGYGLTET--MAQTHSnPPD--RPKLQCLG--IPTfgVDARVIDPE 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 436 agTLAKL--NTPGELCIRGYCVMLGYWGEPQKTEEA---VDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPA 510
Cdd:PRK08314 375 --TLEELppGEVGEIVVHGPQVFKGYWNRPEATAEAfieIDGKRFFRTGDLGRMDEEGYFFITDRLKRMINASGFKVWPA 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 511 ELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEE--TTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQ 588
Cdd:PRK08314 453 EVENLLYKHPAIQEACVIATPDPRRGETVKAVVVLRPEARgkTTEEEIIAWAREHMAAYKYPRIVEFVDSLPKSGSGKIL 532
|
....*..
gi 572879274 589 KFKLREQ 595
Cdd:PRK08314 533 WRQLQEQ 539
|
|
| PRK08162 |
PRK08162 |
acyl-CoA synthetase; Validated |
78-596 |
2.22e-67 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236169 [Multi-domain] Cd Length: 545 Bit Score: 228.68 E-value: 2.22e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAW------------VLMQLAT- 144
Cdd:PRK08162 24 LERAAEVYPDRPAVI--HGDRRRTWAETYARCRRLASALARRGIGRGDTVAVLLPNIPAMveahfgvpmagaVLNTLNTr 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 145 AQAMELEYVLKKVGCKALVFPKQFKtqqyyNVLKQicpevenaqpgALKSQRLPDLTTVISVDAPLPGTllldevvaags 224
Cdd:PRK08162 102 LDAASIAFMLRHGEAKVLIVDTEFA-----EVARE-----------ALALLPGPKPLVIDVDDPEYPGG----------- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 225 trQHLDQLQYnQQFLSCHDP-------------INIQFTSGTTGSPKGATLSHYNIVNN--SNILGERLKLHektPEQLR 289
Cdd:PRK08162 155 --RFIGALDY-EAFLASGDPdfawtlpadewdaIALNYTSGTTGNPKGVVYHHRGAYLNalSNILAWGMPKH---PVYLW 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 290 MIlpnPLYHCLG--------SVAGTMMCLMYgatlilaspiFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDI 361
Cdd:PRK08162 229 TL---PMFHCNGwcfpwtvaARAGTNVCLRK----------VDPKLIFDLIREHGVTHYCGAPIVLSALINAPAEWRAGI 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 362 STMCGGVIAGSPAPPelirAIINKinMK----DLVVAYGTTEN-SPVTF----AHFPEDTVEQKAESVGR--IMPHTEAR 430
Cdd:PRK08162 296 DHPVHAMVAGAAPPA----AVIAK--MEeigfDLTHVYGLTETyGPATVcawqPEWDALPLDERAQLKARqgVRYPLQEG 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 431 IMNMEAGTLAKL----NTPGELCIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGEN 506
Cdd:PRK08162 370 VTVLDPDTMQPVpadgETIGEIMFRGNIVMKGYLKNPKATEEAF-AGGWFHTGDLAVLHPDGYIKIKDRSKDIIISGGEN 448
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 507 IYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFvTNYPLTISGK 586
Cdd:PRK08162 449 ISSIEVEDVLYRHPAVLVAAVVAKPDPKWGEVPCAFVELKDGASATEEEIIAHCREHLAGFKVPKAVVF-GELPKTSTGK 527
|
570
....*....|
gi 572879274 587 IQKFKLREQM 596
Cdd:PRK08162 528 IQKFVLREQA 537
|
|
| PRK08974 |
PRK08974 |
long-chain-fatty-acid--CoA ligase FadD; |
78-595 |
7.13e-67 |
|
long-chain-fatty-acid--CoA ligase FadD;
Pssm-ID: 236359 [Multi-domain] Cd Length: 560 Bit Score: 227.63 E-value: 7.13e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVVLHEdvRLTFAQLkEEVDKAASGLLS--IGLCKGDRLGMWGPNsyawvLMQLATA------QAM- 148
Cdd:PRK08974 29 FEQAVARYADQPAFINMGE--VMTFRKL-EERSRAFAAYLQngLGLKKGDRVALMMPN-----LLQYPIAlfgilrAGMi 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 149 -----------ELEYVLKKVGCKALVFPKQFKtqqyyNVLKQIcpeVENAQPGALKSQRLPDLTtvisvdaPLPGTLLLD 217
Cdd:PRK08974 101 vvnvnplytprELEHQLNDSGAKAIVIVSNFA-----HTLEKV---VFKTPVKHVILTRMGDQL-------STAKGTLVN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 218 EVV-------------AAGSTRQHLD---QLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNN--------SNI 273
Cdd:PRK08974 166 FVVkyikrlvpkyhlpDAISFRSALHkgrRMQYVKPELVPEDLAFLQYTGGTTGVAKGAMLTHRNMLANleqakaayGPL 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 274 LGERLKLhektpeqlrMILPNPLYHCLgsvAGTMMCLMY---GATLILaspIFNGKKA---LEAISRERGTFLYGTPTMF 347
Cdd:PRK08974 246 LHPGKEL---------VVTALPLYHIF---ALTVNCLLFielGGQNLL---ITNPRDIpgfVKELKKYPFTAITGVNTLF 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 348 VDILNQPDFSSYDISTMCGGVIAGSPAPpeliRAIINK---INMKDLVVAYGTTENSPVTFAHfPEDTVEQKAeSVGRIM 424
Cdd:PRK08974 311 NALLNNEEFQELDFSSLKLSVGGGMAVQ----QAVAERwvkLTGQYLLEGYGLTECSPLVSVN-PYDLDYYSG-SIGLPV 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 425 PHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEaVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGG 504
Cdd:PRK08974 385 PSTEIKLVD-DDGNEVPPGEPGELWVKGPQVMLGYWQRPEATDE-VIKDGWLATGDIAVMDEEGFLRIVDRKKDMILVSG 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 505 ENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDgEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTIS 584
Cdd:PRK08974 463 FNVYPNEIEDVVMLHPKVLEVAAVGVPSEVSGEAVKIFVVKKD-PSLTEEELITHCRRHLTGYKVPKLVEFRDELPKSNV 541
|
570
....*....|.
gi 572879274 585 GKIQKFKLREQ 595
Cdd:PRK08974 542 GKILRRELRDE 552
|
|
| MCS |
cd05941 |
Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step ... |
243-594 |
1.34e-66 |
|
Malonyl-CoA synthetase (MCS); MCS catalyzes the formation of malonyl-CoA in a two-step reaction consisting of the adenylation of malonate with ATP, followed by malonyl transfer from malonyl-AMP to CoA. Malonic acid and its derivatives are the building blocks of polyketides and malonyl-CoA serves as the substrate of polyketide synthases. Malonyl-CoA synthetase has broad substrate tolerance and can activate a variety of malonyl acid derivatives. MCS may play an important role in biosynthesis of polyketides, the important secondary metabolites with therapeutic and agrochemical utility.
Pssm-ID: 341264 [Multi-domain] Cd Length: 442 Bit Score: 223.71 E-value: 1.34e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 243 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILgerLKLHEKTPEQlRMILPNPLYHCLGSVAGTMMCLMYGATLILaSPI 322
Cdd:cd05941 90 DPALILYTSGTTGRPKGVVLTHANLAANVRAL---VDAWRWTEDD-VLLHVLPLHHVHGLVNALLCPLFAGASVEF-LPK 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 323 FNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGG-------VIAGSPAPPELIRAIINKINMKDLVVAY 395
Cdd:cd05941 165 FDPKEVAISRLMPSITVFMGVPTIYTRLLQYYEAHFTDPQFARAAaaerlrlMVSGSAALPVPTLEEWEAITGHTLLERY 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 396 GTTENSPVTFAhfPEDTvEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKW 475
Cdd:cd05941 245 GMTEIGMALSN--PLDG-ERRPGTVGMPLPGVQARIVDEETGEPLPRGEVGEIQVRGPSVFKEYWNKPEATKEEFTDDGW 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 476 YWTGDVATMNEQGFCKIVGRSKDMII-RGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEET-TV 553
Cdd:cd05941 322 FKTGDLGVVDEDGYYWILGRSSVDIIkSGGYKVSALEIERVLLAHPGVSECAVIGVPDPDWGERVVAVVVLRAGAAAlSL 401
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 572879274 554 EEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 594
Cdd:cd05941 402 EELKEWAKQRLAPYKRPRRLILVDELPRNAMGKVNKKELRK 442
|
|
| LC_FACS_like |
cd05935 |
Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain ... |
99-587 |
1.71e-65 |
|
Putative long-chain fatty acid CoA ligase; The members of this family are putative long-chain fatty acyl-CoA synthetases, which catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters.
Pssm-ID: 341258 [Multi-domain] Cd Length: 430 Bit Score: 220.43 E-value: 1.71e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 99 RLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWV-----LMQLATA--------QAMELEYVLKKVGCKALVfp 165
Cdd:cd05935 1 SLTYLELLEVVKKLASFLSNKGVRKGDRVGICLQNSPQYViayfaIWRANAVvvpinpmlKERELEYILNDSGAKVAV-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 166 kqfktqqyynvlkqicpevenaqpgalksqrlpdlttvisvdaplpgtllldevvaAGSTrqhLDQLQYnqqflschdpi 245
Cdd:cd05935 79 --------------------------------------------------------VGSE---LDDLAL----------- 88
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 246 nIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQLrMILPNPLYHCLGSVaGTMMCLMY-GATLILASpIFN 324
Cdd:cd05935 89 -IPYTSGTTGLPKGCMHTHFSAAANALQSAVWTGL---TPSDV-ILACLPLFHVTGFV-GSLNTAVYvGGTYVLMA-RWD 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 325 GKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMkDLVVAYGTTENSPVT 404
Cdd:cd05935 162 RETALELIEKYKVTFWTNIPTMLVDLLATPEFKTRDLSSLKVLTGGGAPMPPAVAEKLLKLTGL-RFVEGYGLTETMSQT 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 405 FAHFPEdtvEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEA---VDQDKWYWTGDV 481
Cdd:cd05935 241 HTNPPL---RPKLQCLGIP*FGVDARVIDIETGRELPPNEVGEIVVRGPQIFKGYWNRPEETEESfieIKGRRFFRTGDL 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 482 ATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGE--ETTVEEIKAF 559
Cdd:cd05935 318 GYMDEEGYFFFVDRVKRMINVSGFKVWPAEVEAKLYKHPAI*EVCVISVPDERVGEEVKAFIVLRPEYrgKVTEEDIIEW 397
|
490 500
....*....|....*....|....*...
gi 572879274 560 CKGKISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:cd05935 398 AREQMAAYKYPREVEFVDELPRSASGKI 425
|
|
| PRK07529 |
PRK07529 |
AMP-binding domain protein; Validated |
78-594 |
1.05e-64 |
|
AMP-binding domain protein; Validated
Pssm-ID: 236043 [Multi-domain] Cd Length: 632 Bit Score: 223.68 E-value: 1.05e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVVLH------EDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNS--YAWVLMQLATA---- 145
Cdd:PRK07529 31 LSRAAARHPDAPALSFLLdadpldRPETWTYAELLADVTRTANLLHSLGVGPGDVVAFLLPNLpeTHFALWGGEAAgian 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 146 ---QAMELEYV---LKKVGCKALV----FPKQfktqqyynvlkQICPEVENAQPgalksqRLPDLTTVISVDAPLPGTLL 215
Cdd:PRK07529 111 pinPLLEPEQIaelLRAAGAKVLVtlgpFPGT-----------DIWQKVAEVLA------ALPELRTVVEVDLARYLPGP 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 216 LDEVVAAGSTRQHLDQLQYNQQF-------LSCHDPINIQ-----F-TSGTTGSPKGATLSHYNIVNNSNILGERLKL-H 281
Cdd:PRK07529 174 KRLAVPLIRRKAHARILDFDAELarqpgdrLFSGRPIGPDdvaayFhTGGTTGMPKLAQHTHGNEVANAWLGALLLGLgP 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 282 EKTpeqlrMILPNPLYHCLGSVAGTMMCLMYGATLILASPI-FNGKKAL----EAISRERGTFLYGTPTMFVDILNQPdF 356
Cdd:PRK07529 254 GDT-----VFCGLPLFHVNALLVTGLAPLARGAHVVLATPQgYRGPGVIanfwKIVERYRINFLSGVPTVYAALLQVP-V 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 357 SSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGTTENSPVTFAHFPEDtvEQKAESVGRIMPHTEARIMNM-E 435
Cdd:PRK07529 328 DGHDISSLRYALCGAAPLPVEVFRRFEAATGVR-IVEGYGLTEATCVSSVNPPDG--ERRIGSVGLRLPYQRVRVVILdD 404
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 436 AGTL---AKLNTPGELCIRGYCVMLGYWgEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAEL 512
Cdd:PRK07529 405 AGRYlrdCAVDEVGVLCIAGPNVFSGYL-EAAHNKGLWLEDGWLNTGDLGRIDADGYFWLTGRAKDLIIRGGHNIDPAAI 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 513 EDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISH-FKIPKYIVFVTNYPLTISGKIQKFK 591
Cdd:PRK07529 484 EEALLRHPAVALAAAVGRPDAHAGELPVAYVQLKPGASATEAELLAFARDHIAErAAVPKHVRILDALPKTAVGKIFKPA 563
|
...
gi 572879274 592 LRE 594
Cdd:PRK07529 564 LRR 566
|
|
| PRK12492 |
PRK12492 |
long-chain-fatty-acid--CoA ligase; Provisional |
72-594 |
1.83e-64 |
|
long-chain-fatty-acid--CoA ligase; Provisional
Pssm-ID: 171539 [Multi-domain] Cd Length: 562 Bit Score: 221.62 E-value: 1.83e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 72 KTVGQCLETTAQRVPEREALVVLheDVRLTFAQLkEEVDKAASGLLS--IGLCKGDRLGMWGPNsyawvLMQLATA---- 145
Cdd:PRK12492 24 KSVVEVFERSCKKFADRPAFSNL--GVTLSYAEL-ERHSAAFAAYLQqhTDLVPGDRIAVQMPN-----VLQYPIAvfga 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 146 --------------QAMELEYVLKKVGCKALVFPKQFKtqqyyNVLKQICPEVE-----NAQPGALksqrLPDL------ 200
Cdd:PRK12492 96 lraglivvntnplyTAREMRHQFKDSGARALVYLNMFG-----KLVQEVLPDTGieyliEAKMGDL----LPAAkgwlvn 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 201 TTVISVDAPLPGTLLLDEVVAAGSTRQHLDQ-LQYNQQFLSchDPINIQFTSGTTGSPKGATLSHYNIVnnSNILGERLK 279
Cdd:PRK12492 167 TVVDKVKKMVPAYHLPQAVPFKQALRQGRGLsLKPVPVGLD--DIAVLQYTGGTTGLAKGAMLTHGNLV--ANMLQVRAC 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 280 LHEKTPE--------QLRMILPNPLYHCLGSVAGTMMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDIL 351
Cdd:PRK12492 243 LSQLGPDgqplmkegQEVMIAPLPLYHIYAFTANCMCMMVSGNHNVLITNPRDIPGFIKELGKWRFSALLGLNTLFVALM 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 352 NQPDFSSYDISTMCGGVIAGSPappeLIRAIINK---INMKDLVVAYGTTENSPVTFAHfPEDTvEQKAESVGRIMPHTE 428
Cdd:PRK12492 323 DHPGFKDLDFSALKLTNSGGTA----LVKATAERweqLTGCTIVEGYGLTETSPVASTN-PYGE-LARLGTVGIPVPGTA 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 429 ARIMNMEAGTLAkLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIY 508
Cdd:PRK12492 397 LKVIDDDGNELP-LGERGELCIKGPQVMKGYWQQPEATAEALDAEGWFKTGDIAVIDPDGFVRIVDRKKDLIIVSGFNVY 475
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 509 PAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGeETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQ 588
Cdd:PRK12492 476 PNEIEDVVMAHPKVANCAAIGVPDERSGEAVKLFVVARDP-GLSVEELKAYCKENFTGYKVPKHIVLRDSLPMTPVGKIL 554
|
....*.
gi 572879274 589 KFKLRE 594
Cdd:PRK12492 555 RRELRD 560
|
|
| PRK07059 |
PRK07059 |
Long-chain-fatty-acid--CoA ligase; Validated |
73-593 |
3.58e-64 |
|
Long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235923 [Multi-domain] Cd Length: 557 Bit Score: 220.66 E-value: 3.58e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 73 TVGQCLETTAQRVPEREALVVLheDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQA----- 147
Cdd:PRK07059 24 SLADLLEESFRQYADRPAFICM--GKAITYGELDELSRALAAWLQSRGLAKGARVAIMMPNVLQYPVAIAAVLRAgyvvv 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 148 --------MELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEVENAQPG---ALKS-------QRLPDLTTVISvdap 209
Cdd:PRK07059 102 nvnplytpRELEHQLKDSGAEAIVVLENFATTVQQVLAKTAVKHVVVASMGdllGFKGhivnfvvRRVKKMVPAWS---- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 210 LPGTLLLDEVVAAGSTrqhldqLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVnnSNILGERLKLH-----EKT 284
Cdd:PRK07059 178 LPGHVRFNDALAEGAR------QTFKPVKLGPDDVAFLQYTGGTTGVSKGATLLHRNIV--ANVLQMEAWLQpafekKPR 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 285 PEQLRMILPNPLYHCLGSVAGTMMCLMYGATLIL-ASP--IFNGKKALEaisRERGTFLYGTPTMFVDILNQPDFSSYDI 361
Cdd:PRK07059 250 PDQLNFVCALPLYHIFALTVCGLLGMRTGGRNILiPNPrdIPGFIKELK---KYQVHIFPAVNTLYNALLNNPDFDKLDF 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 362 STMcGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHfPEDTVEQKAeSVGRIMPHTEARIMNmEAGTLAK 441
Cdd:PRK07059 327 SKL-IVANGGGMAVQRPVAERWLEMTGCPITEGYGLSETSPVATCN-PVDATEFSG-TIGLPLPSTEVSIRD-DDGNDLP 402
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 442 LNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPK 521
Cdd:PRK07059 403 LGEPGEICIRGPQVMAGYWNRPDETAKVMTADGFFRTGDVGVMDERGYTKIVDRKKDMILVSGFNVYPNEIEEVVASHPG 482
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 572879274 522 VQEVQVVGVKDDRMGEEICACIRLKDgEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 593
Cdd:PRK07059 483 VLEVAAVGVPDEHSGEAVKLFVVKKD-PALTEEDVKAFCKERLTNYKRPKFVEFRTELPKTNVGKILRRELR 553
|
|
| PRK09088 |
PRK09088 |
acyl-CoA synthetase; Validated |
82-596 |
1.64e-63 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 181644 [Multi-domain] Cd Length: 488 Bit Score: 216.98 E-value: 1.64e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 82 AQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAqameleyvlkKVGckA 161
Cdd:PRK09088 5 ARLQPQRLAAVDLALGRRWTYAELDALVGRLAAVLRRRGCVDGERLAVLARNSVWLVALHFACA----------RVG--A 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 162 LVFPKQFKTQQyynvlKQICPEVENAQPgalksqRLpdlttvisvdaplpgtLLLDEVVAAGSTR-QHLDQLQYNqqfLS 240
Cdd:PRK09088 73 IYVPLNWRLSA-----SELDALLQDAEP------RL----------------LLGDDAVAAGRTDvEDLAAFIAS---AD 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 241 CHDPIN-----------IQFTSGTTGSPKGATLSHYNI---VNNSNILGerlklheKTPEQLRMILPNPLYHCLGSVAGT 306
Cdd:PRK09088 123 ALEPADtpsippervslILFTSGTSGQPKGVMLSERNLqqtAHNFGVLG-------RVDAHSSFLCDAPMFHIIGLITSV 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 307 MMCLMYGATlILASPIFNGKKALEAISRER--GTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIIN 384
Cdd:PRK09088 196 RPVLAVGGS-ILVSNGFEPKRTLGRLGDPAlgITHYFCVPQMAQAFRAQPGFDAAALRHLTALFTGGAPHAAEDILGWLD 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 385 K-INMKDlvvAYGTTENSPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEP 463
Cdd:PRK09088 275 DgIPMVD---GFGMSEAGTVFGMSVDCDVIRAKAGAAGIPTPTVQTRVVD-DQGNDCPAGVPGELLLRGPNLSPGYWRRP 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 464 QKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACI 543
Cdd:PRK09088 351 QATARAFTGDGWFRTGDIARRDADGFFWVVDRKKDMFISGGENVYPAEIEAVLADHPGIRECAVVGMADAQWGEVGYLAI 430
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 572879274 544 RLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQM 596
Cdd:PRK09088 431 VPADGAPLDLERIRSHLSTRLAKYKVPKHLRLVDALPRTASGKLQKARLRDAL 483
|
|
| PRK08276 |
PRK08276 |
long-chain-fatty-acid--CoA ligase; Validated |
90-595 |
3.55e-63 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236215 [Multi-domain] Cd Length: 502 Bit Score: 216.31 E-value: 3.55e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 90 ALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQ-------------AMELEYVLKK 156
Cdd:PRK08276 2 AVIMAPSGEVVTYGELEARSNRLAHGLRALGLREGDVVAILLENNPEFFEVYWAARRsglyytpinwhltAAEIAYIVDD 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 157 VGCKALVFpkqfkTQQYYNVLKQICPEVENaqpgalksqrlpDLTTVISVDAPLPGTLLLDEVVAAGSTRQHLDQLqynq 236
Cdd:PRK08276 82 SGAKVLIV-----SAALADTAAELAAELPA------------GVPLLLVVAGPVPGFRSYEEALAAQPDTPIADET---- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 237 qfLSCHdpinIQFTSGTTGSPKG--ATLSHYNIVNNSN----ILGERLKLHEKTpeqlRMILPNPLYHCLGSVAGtMMCL 310
Cdd:PRK08276 141 --AGAD----MLYSSGTTGRPKGikRPLPGLDPDEAPGmmlaLLGFGMYGGPDS----VYLSPAPLYHTAPLRFG-MSAL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 311 MYGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDF--SSYDISTMCGGVIAGSPAPPELIRAIIN---K 385
Cdd:PRK08276 210 ALGGTVVVM-EKFDAEEALALIERYRVTHSQLVPTMFVRMLKLPEEvrARYDVSSLRVAIHAAAPCPVEVKRAMIDwwgP 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 386 InmkdLVVAYGTTENSPVTFAHfPEDTVEQKAeSVGRIMpHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQK 465
Cdd:PRK08276 289 I----IHEYYASSEGGGVTVIT-SEDWLAHPG-SVGKAV-LGEVRILD-EDGNELPPGEIGTVYFEMDGYPFEYHNDPEK 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 466 TEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRL 545
Cdd:PRK08276 361 TAAARNPHGWVTVGDVGYLDEDGYLYLTDRKSDMIISGGVNIYPQEIENLLVTHPKVADVAVFGVPDEEMGERVKAVVQP 440
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 572879274 546 KDGEETTVE---EIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:PRK08276 441 ADGADAGDAlaaELIAWLRGRLAHYKCPRSIDFEDELPRTPTGKLYKRRLRDR 493
|
|
| OSB_CoA_lg |
cd05912 |
O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA ... |
100-594 |
9.99e-63 |
|
O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); O-succinylbenzoic acid-CoA synthase catalyzes the coenzyme A (CoA)- and ATP-dependent conversion of o-succinylbenzoic acid to o-succinylbenzoyl-CoA. The reaction is the fourth step of the biosynthesis pathway of menaquinone (vitamin K2). In certain bacteria, menaquinone is used during fumarate reduction in anaerobic respiration. In cyanobacteria, the product of the menaquinone pathway is phylloquinone (2-methyl-3-phytyl-1,4-naphthoquinone), a molecule used exclusively as an electron transfer cofactor in Photosystem 1. In green sulfur bacteria and heliobacteria, menaquinones are used as loosely bound secondary electron acceptors in the photosynthetic reaction center.
Pssm-ID: 341238 [Multi-domain] Cd Length: 411 Bit Score: 212.59 E-value: 9.99e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 100 LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLAtaqameleyvLKKVGCKALvfpkqfktqqyynvlkq 179
Cdd:cd05912 2 YTFAELFEEVSRLAEHLAALGVRKGDRVALLSKNSIEMILLIHA----------LWLLGAEAV----------------- 54
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 180 icpevenaqpgaLKSQRLpdlttvisvdaplpgtllldevvaagSTRQHLDQLQYNQqfLSCHDPINIQFTSGTTGSPKG 259
Cdd:cd05912 55 ------------LLNTRL--------------------------TPNELAFQLKDSD--VKLDDIATIMYTSGTTGKPKG 94
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 260 ATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCLG-SVagTMMCLMYGATLILAsPIFNGKKALEAISRERGT 338
Cdd:cd05912 95 VQQTFGNHWWSAIGSALNLGLTEDD----NWLCALPLFHISGlSI--LMRSVIYGMTVYLV-DKFDAEQVLHLINSGKVT 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 339 FLYGTPTMFVDILNQ-PDFSSYDISTMCGGviaGSPAPPELIRaiinKINMKDLVV--AYGTTENSP--VTFAhfPEDTV 413
Cdd:cd05912 168 IISVVPTMLQRLLEIlGEGYPNNLRCILLG---GGPAPKPLLE----QCKEKGIPVyqSYGMTETCSqiVTLS--PEDAL 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 414 EqKAESVGRIMPHTEARIMNmeagTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIV 493
Cdd:cd05912 239 N-KIGSAGKPLFPVELKIED----DGQPPYEVGEILLKGPNVTKGYLNRPDATEESF-ENGWFKTGDIGYLDEEGFLYVL 312
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 494 GRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKdgEETTVEEIKAFCKGKISHFKIPKYI 573
Cdd:cd05912 313 DRRSDLIISGGENIYPAEIEEVLLSHPAIKEAGVVGIPDDKWGQVPVAFVVSE--RPISEEELIAYCSEKLAKYKVPKKI 390
|
490 500
....*....|....*....|.
gi 572879274 574 VFVTNYPLTISGKIQKFKLRE 594
Cdd:cd05912 391 YFVDELPRTASGKLLRHELKQ 411
|
|
| PRK12406 |
PRK12406 |
long-chain-fatty-acid--CoA ligase; Provisional |
97-595 |
1.47e-61 |
|
long-chain-fatty-acid--CoA ligase; Provisional
Pssm-ID: 183506 [Multi-domain] Cd Length: 509 Bit Score: 212.25 E-value: 1.47e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 97 DVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLAT-------------AQAMELEYVLKKVGCKALV 163
Cdd:PRK12406 9 DRRRSFDELAQRAARAAGGLAALGVRPGDCVALLMRNDFAFFEAAYAAmrlgayavpvnwhFKPEEIAYILEDSGARVLI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 164 FPKQFkTQQYYNVLKQICPEVENAQPGALKSQ-RLPDlttviSVDAPLPGTLLLDEVVAAGSTrqhLDQLQYNQqflsch 242
Cdd:PRK12406 89 AHADL-LHGLASALPAGVTVLSVPTPPEIAAAyRISP-----ALLTPPAGAIDWEGWLAQQEP---YDGPPVPQ------ 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 243 dPINIQFTSGTTGSPKGatlshyniVNNSNILGERLKLHEKT-------PEQLRMILPNPLYHCLGSVAGtMMCLMYGAT 315
Cdd:PRK12406 154 -PQSMIYTSGTTGHPKG--------VRRAAPTPEQAAAAEQMraliyglKPGIRALLTGPLYHSAPNAYG-LRAGRLGGV 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 316 LILaSPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDF--SSYDISTMCGGVIAGSPAPPELIRAIIN----KINMk 389
Cdd:PRK12406 224 LVL-QPRFDPEELLQLIERHRITHMHMVPTMFIRLLKLPEEvrAKYDVSSLRHVIHAAAPCPADVKRAMIEwwgpVIYE- 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 390 dlvvAYGTTENSPVTFAHfPEDTVeQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELcirgYCVMLG-----YWGEPQ 464
Cdd:PRK12406 302 ----YYGSTESGAVTFAT-SEDAL-SHPGTVGKAAPGAELRFVD-EDGRPLPQGEIGEI----YSRIAGnpdftYHNKPE 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 465 KTEEaVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIR 544
Cdd:PRK12406 371 KRAE-IDRGGFITSGDVGYLDADGYLFLCDRKRDMVISGGVNIYPAEIEAVLHAVPGVHDCAVFGIPDAEFGEALMAVVE 449
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 572879274 545 LKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:PRK12406 450 PQPGATLDEADIRAQLKARLAGYKVPKHIEIMAELPREDSGKIFKRRLRDP 500
|
|
| PRK08751 |
PRK08751 |
long-chain fatty acid--CoA ligase; |
72-594 |
2.64e-61 |
|
long-chain fatty acid--CoA ligase;
Pssm-ID: 181546 [Multi-domain] Cd Length: 560 Bit Score: 212.81 E-value: 2.64e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 72 KTVGQCLETTAQRVPEREALVVLHEdvRLTFAQLKEEVDKAASGLLS-IGLCKGDRLGMWGPNSYAWVLMQLATAQA--- 147
Cdd:PRK08751 25 RTVAEVFATSVAKFADRPAYHSFGK--TITYREADQLVEQFAAYLLGeLQLKKGDRVALMMPNCLQYPIATFGVLRAglt 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 148 ----------MELEYVLKKVGCKALVFPKQFKT--QQYY--NVLKQICP----EVENAQPGALKSQRLPDLTTVISvDAP 209
Cdd:PRK08751 103 vvnvnplytpRELKHQLIDSGASVLVVIDNFGTtvQQVIadTPVKQVITtglgDMLGFPKAALVNFVVKYVKKLVP-EYR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 210 LPGTLLLDEVVAAGStRQHLDQLQYNqqflscHDPIN-IQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQL 288
Cdd:PRK08751 182 INGAIRFREALALGR-KHSMPTLQIE------PDDIAfLQYTGGTTGVAKGAMLTHRNLVANMQQAHQWLAGTGKLEEGC 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 289 RMILPN-PLYHCLGSVAGTMMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTM--- 364
Cdd:PRK08751 255 EVVITAlPLYHIFALTANGLVFMKIGGCNHLISNPRDMPGFVKELKKTRFTAFTGVNTLFNGLLNTPGFDQIDFSSLkmt 334
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 365 CGGVIAGSPAPPELIRaiinKINMKDLVVAYGTTENSPVTFAHfPEDTVEQKAeSVGRIMPHTEARIMNmEAGTLAKLNT 444
Cdd:PRK08751 335 LGGGMAVQRSVAERWK----QVTGLTLVEAYGLTETSPAACIN-PLTLKEYNG-SIGLPIPSTDACIKD-DAGTVLAIGE 407
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 445 PGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQE 524
Cdd:PRK08751 408 IGELCIKGPQVMKGYWKRPEETAKVMDADGWLHTGDIARMDEQGFVYIVDRKKDMILVSGFNVYPNEIEDVIAMMPGVLE 487
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 525 VQVVGVKDDRMGEEICACIRLKDgEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 594
Cdd:PRK08751 488 VAAVGVPDEKSGEIVKVVIVKKD-PALTAEDVKAHARANLTGYKQPRIIEFRKELPKTNVGKILRRELRD 556
|
|
| PRK03640 |
PRK03640 |
o-succinylbenzoate--CoA ligase; |
82-598 |
4.92e-61 |
|
o-succinylbenzoate--CoA ligase;
Pssm-ID: 235146 [Multi-domain] Cd Length: 483 Bit Score: 210.20 E-value: 4.92e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 82 AQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQ-------------AM 148
Cdd:PRK03640 12 AFLTPDRTAIE--FEEKKVTFMELHEAVVSVAGKLAALGVKKGDRVALLMKNGMEMILVIHALQQlgavavllntrlsRE 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 149 ELEYVLKKVGCKALVFPKQFKTQQYynvlkqicpevenaqpgALKSQRLPDLTTVISVDAPLPGTLLLDEVVAagstrqh 228
Cdd:PRK03640 90 ELLWQLDDAEVKCLITDDDFEAKLI-----------------PGISVKFAELMNGPKEEAEIQEEFDLDEVAT------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 229 ldqlqynqqflschdpinIQFTSGTTGSPKGATLSHYN----IVNNSNILGerlkLHEKTpeqlRMILPNPLYHCLG-SV 303
Cdd:PRK03640 146 ------------------IMYTSGTTGKPKGVIQTYGNhwwsAVGSALNLG----LTEDD----CWLAAVPIFHISGlSI 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 304 AgtMMCLMYGATLILASPiFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSY--DISTMCGGviaGSPAPPELIRa 381
Cdd:PRK03640 200 L--MRSVIYGMRVVLVEK-FDAEKINKLLQTGGVTIISVVSTMLQRLLERLGEGTYpsSFRCMLLG---GGPAPKPLLE- 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 382 iinKINMKDLVV--AYGTTENSP--VTFAhfPEDTVEqKAESVGRIMPHTEARIMnmEAGTLAKLNTPGELCIRGYCVML 457
Cdd:PRK03640 273 ---QCKEKGIPVyqSYGMTETASqiVTLS--PEDALT-KLGSAGKPLFPCELKIE--KDGVVVPPFEEGEIVVKGPNVTK 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 458 GYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGE 537
Cdd:PRK03640 345 GYLNREDATRETF-QDGWFKTGDIGYLDEEGFLYVLDRRSDLIISGGENIYPAEIEEVLLSHPGVAEAGVVGVPDDKWGQ 423
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 572879274 538 EICACIRLkdGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMER 598
Cdd:PRK03640 424 VPVAFVVK--SGEVTEEELRHFCEEKLAKYKVPKRFYFVEELPRNASGKLLRHELKQLVEE 482
|
|
| PRK07470 |
PRK07470 |
acyl-CoA synthetase; Validated |
75-598 |
6.59e-61 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 180988 [Multi-domain] Cd Length: 528 Bit Score: 211.05 E-value: 6.59e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 75 GQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSyawvlmqlatAQAMELEYVL 154
Cdd:PRK07470 10 AHFLRQAARRFPDRIALV--WGDRSWTWREIDARVDALAAALAARGVRKGDRILVHSRNC----------NQMFESMFAA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 155 KKVGckALVFPKQFK-TQQYYNVLKQ-------ICpEVENAQPGALKSQRLPDLTTVISVDAPlPGTLLLDEVVAAGSTR 226
Cdd:PRK07470 78 FRLG--AVWVPTNFRqTPDEVAYLAEasgaramIC-HADFPEHAAAVRAASPDLTHVVAIGGA-RAGLDYEALVARHLGA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 227 QHLD-QLQYNqqflschDPINIQFTSGTTGSPKGATLSHYN---IVNNSniLGErlkLHEKTPEQLRMILPNPLYHclGs 302
Cdd:PRK07470 154 RVANaAVDHD-------DPCWFFFTSGTTGRPKAAVLTHGQmafVITNH--LAD---LMPGTTEQDASLVVAPLSH--G- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 303 vAGT--MMCLMYGA-TLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSP---APP 376
Cdd:PRK07470 219 -AGIhqLCQVARGAaTVLLPSERFDPAEVWALVERHRVTNLFTVPTILKMLVEHPAVDRYDHSSLRYVIYAGAPmyrADQ 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 377 ELIRAIINKInmkdLVVAYGTTEnspVT--------FAHFPEDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGEL 448
Cdd:PRK07470 298 KRALAKLGKV----LVQYFGLGE---VTgnitvlppALHDAEDGPDARIGTCGFERTGMEVQIQD-DEGRELPPGETGEI 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 449 CIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVV 528
Cdd:PRK07470 370 CVIGPAVFAGYYNNPEANAKAF-RDGWFRTGDLGHLDARGFLYITGRASDMYISGGSNVYPREIEEKLLTHPAVSEVAVL 448
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 529 GVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMER 598
Cdd:PRK07470 449 GVPDPVWGEVGVAVCVARDGAPVDEAELLAWLDGKVARYKLPKRFFFWDALPKSGYGKITKKMVREELEE 518
|
|
| PRK07786 |
PRK07786 |
long-chain-fatty-acid--CoA ligase; Validated |
78-595 |
8.83e-61 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 169098 [Multi-domain] Cd Length: 542 Bit Score: 211.17 E-value: 8.83e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVVLHEDvrLTFAQLKEEVDKAASGLLSIGLCKGDRLgmwgpnsyawVLMQLATAQAMELEYVLKKV 157
Cdd:PRK07786 23 LARHALMQPDAPALRFLGNT--TTWRELDDRVAALAGALSRRGVGFGDRV----------LILMLNRTEFVESVLAANML 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 158 GckALVFPKQFKTQQyynvlKQICPEVENAQPGALKSQR-LPDLTTVISVDAPLPGTLlldeVVAAGSTRQhlDQLQYNQ 236
Cdd:PRK07786 91 G--AIAVPVNFRLTP-----PEIAFLVSDCGAHVVVTEAaLAPVATAVRDIVPLLSTV----VVAGGSSDD--SVLGYED 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 237 QFLS---CHDPIN--------IQFTSGTTGSPKGATLSHYNIVNNS--NILGERLKLHEKTPeqlrmILPNPLYHC--LG 301
Cdd:PRK07786 158 LLAEagpAHAPVDipndspalIMYTSGTTGRPKGAVLTHANLTGQAmtCLRTNGADINSDVG-----FVGVPLFHIagIG 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 302 SVAGTmmcLMYGATLILaSPI--FNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMcggVIA--GSPAPPE 377
Cdd:PRK07786 233 SMLPG---LLLGAPTVI-YPLgaFDPGQLLDVLEAEKVTGIFLVPAQWQAVCAEQQARPRDLALR---VLSwgAAPASDT 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 378 LIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVeQKAESVGRIMPHTEARIMNMEAGTLAkLNTPGELCIRGYCVML 457
Cdd:PRK07786 306 LLRQMAATFPEAQILAAFGQTEMSPVTCMLLGEDAI-RKLGSVGKVIPTVAARVVDENMNDVP-VGEVGEIVYRAPTLMS 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 458 GYWGEPQKTEEAVDqDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGE 537
Cdd:PRK07786 384 GYWNNPEATAEAFA-GGWFHSGDLVRQDEEGYVWVVDRKKDMIISGGENIYCAEVENVLASHPDIVEVAVIGRADEKWGE 462
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 572879274 538 EICACIRLKDG-EETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:PRK07786 463 VPVAVAAVRNDdAALTLEDLAEFLTDRLARYKHPKALEIVDALPRNPAGKVLKTELRER 521
|
|
| caiC |
PRK08008 |
putative crotonobetaine/carnitine-CoA ligase; Validated |
71-593 |
3.88e-60 |
|
putative crotonobetaine/carnitine-CoA ligase; Validated
Pssm-ID: 181195 [Multi-domain] Cd Length: 517 Bit Score: 208.77 E-value: 3.88e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 71 SKTVGQCLETTAQRVPEREALVV--LHEDVR-LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNS----YAW------ 137
Cdd:PRK08008 6 GQHLRQMWDDLADVYGHKTALIFesSGGVVRrYSYLELNEEINRTANLFYSLGIRKGDKVALHLDNCpefiFCWfglaki 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 138 -VLMQLATAQAM--ELEYVLKKVGCKALVFPKQFktqqyYNVLKQICPEVenaqpgalksqrlpdlttvisvDAPLPGTL 214
Cdd:PRK08008 86 gAIMVPINARLLreESAWILQNSQASLLVTSAQF-----YPMYRQIQQED----------------------ATPLRHIC 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 215 LLDEVVAAGSTRQHLDQLQyNQQF--------LSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpe 286
Cdd:PRK08008 139 LTRVALPADDGVSSFTQLK-AQQPatlcyappLSTDDTAEILFTSGTTSRPKGVVITHYNLRFAGYYSAWQCALRDDD-- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 287 qlRMILPNPLYHCLGSVAGTMMCLMYGATLILASPiFNGKKALEAISRERGTFLYGTPTMFVDILNQPdfssydistmcg 366
Cdd:PRK08008 216 --VYLTVMPAFHIDCQCTAAMAAFSAGATFVLLEK-YSARAFWGQVCKYRATITECIPMMIRTLMVQP------------ 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 367 gviagsPAPPE---LIRAIINKINMKD-------------LVVAYGTTENSPVTFAHFPEDtvEQKAESVGRIMPHTEAR 430
Cdd:PRK08008 281 ------PSANDrqhCLREVMFYLNLSDqekdafeerfgvrLLTSYGMTETIVGIIGDRPGD--KRRWPSIGRPGFCYEAE 352
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 431 IMNmEAGTLAKLNTPGELCIRGY---CVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENI 507
Cdd:PRK08008 353 IRD-DHNRPLPAGEIGEICIKGVpgkTIFKEYYLDPKATAKVLEADGWLHTGDTGYVDEEGFFYFVDRRCNMIKRGGENV 431
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 508 YPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:PRK08008 432 SCVELENIIATHPKIQDIVVVGIKDSIRDEAIKAFVVLNEGETLSEEEFFAFCEQNMAKFKVPSYLEIRKDLPRNCSGKI 511
|
....*.
gi 572879274 588 QKFKLR 593
Cdd:PRK08008 512 IKKNLK 517
|
|
| VL_LC_FACS_like |
cd05907 |
Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA ... |
100-534 |
6.73e-60 |
|
Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; This family includes long-chain fatty acid (C12-C20) CoA synthetases and Bubblegum-like very long-chain (>C20) fatty acid CoA synthetases. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Drosophila melanogaster mutant bubblegum (BGM) have elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene later named bubblegum. The human homolog (hsBG) of bubblegum has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341233 [Multi-domain] Cd Length: 452 Bit Score: 206.29 E-value: 6.73e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 100 LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLA-------------TAQAMELEYVLKKVGCKALVfpk 166
Cdd:cd05907 6 ITWAEFAEEVRALAKGLIALGVEPGDRVAILSRNRPEWTIADLAilaigavpvpiypTSSAEQIAYILNDSEAKALF--- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 167 qfktqqyynvlkqicpeVENAQpgalksqrlpDLTTVIsvdaplpgtllldevvaagstrqhldqlqynqqflschdpin 246
Cdd:cd05907 83 -----------------VEDPD----------DLATII------------------------------------------ 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 247 iqFTSGTTGSPKGATLSHYNIVNNSNILGERLklhEKTPEQlRMILPNPLYHCLGSVAGTMMCLMYGATLILASPIfngK 326
Cdd:cd05907 94 --YTSGTTGRPKGVMLSHRNILSNALALAERL---PATEGD-RHLSFLPLAHVFERRAGLYVPLLAGARIYFASSA---E 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 327 KALEAISRERGTFLYGTPTMFvdilnQPDFSSYDISTMCGG----------------VIAGSPAPPELIRaIINKINMkD 390
Cdd:cd05907 165 TLLDDLSEVRPTVFLAVPRVW-----EKVYAAIKVKAVPGLkrklfdlavggrlrfaASGGAPLPAELLH-FFRALGI-P 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 391 LVVAYGTTENSPVTFAHFPEDtveQKAESVGRIMPHTEARIMNmeagtlaklntPGELCIRGYCVMLGYWGEPQKTEEAV 470
Cdd:cd05907 238 VYEGYGLTETSAVVTLNPPGD---NRIGTVGKPLPGVEVRIAD-----------DGEILVRGPNVMLGYYKNPEATAEAL 303
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 572879274 471 DQDKWYWTGDVATMNEQGFCKIVGRSKDMII-RGGENIYPAELEDFFHTHPKVQEVQVVGvkDDR 534
Cdd:cd05907 304 DADGWLHTGDLGEIDEDGFLHITGRKKDLIItSGGKNISPEPIENALKASPLISQAVVIG--DGR 366
|
|
| menE |
TIGR01923 |
O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, ... |
101-592 |
8.43e-60 |
|
O-succinylbenzoate-CoA ligase; This model represents an enzyme, O-succinylbenzoate-CoA ligase, which is involved in the fourth step of the menaquinone biosynthesis pathway. O-succinylbenzoate-CoA ligase, together with menB - naphtoate synthase, take 2-succinylbenzoate and convert it into 1,4-di-hydroxy-2- naphtoate. [Biosynthesis of cofactors, prosthetic groups, and carriers, Menaquinone and ubiquinone]
Pssm-ID: 162605 [Multi-domain] Cd Length: 436 Bit Score: 205.76 E-value: 8.43e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 101 TFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLAtaqameleyvLKKVGCKALVFPKQFKTQQYYNVLKQI 180
Cdd:TIGR01923 1 TWQDLDCEAAHLAKALKAQGIRSGSRVALVGQNSIEMVLLLHA----------CLLLGAEIAMLNTRLTENERTNQLEDL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 181 cpevenaQPGALKSQRLPDLTTVISVDaplpgtllLDEVVAAGstrqhLDQLQYNQQFlSCHDPINIQFTSGTTGSPKGA 260
Cdd:TIGR01923 71 -------DVQLLLTDSLLEEKDFQADS--------LDRIEAAG-----RYETSLSASF-NMDQIATLMFTSGTTGKPKAV 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 261 TLSHYNIVNNSniLGERLKLHekTPEQLRMILPNPLYHcLGSVAGTMMCLMYGATLILASPiFNgkKALEAISRERGTFL 340
Cdd:TIGR01923 130 PHTFRNHYASA--VGSKENLG--FTEDDNWLLSLPLYH-ISGLSILFRWLIEGATLRIVDK-FN--QLLEMIANERVTHI 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 341 YGTPTMFVDILNQpDFSSYDISTMCGGviaGSPAPPELIR-AIINKInmkDLVVAYGTTENSPVTFAHFPEDTVEQKaeS 419
Cdd:TIGR01923 202 SLVPTQLNRLLDE-GGHNENLRKILLG---GSAIPAPLIEeAQQYGL---PIYLSYGMTETCSQVTTATPEMLHARP--D 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 420 VGRIMPHTEARIMNmeagtlAKLNTPGELCIRGYCVMLGYWGEPQKTEeAVDQDKWYWTGDVATMNEQGFCKIVGRSKDM 499
Cdd:TIGR01923 273 VGRPLAGREIKIKV------DNKEGHGEIMVKGANLMKGYLYQGELTP-AFEQQGWFNTGDIGELDGEGFLYVLGRRDDL 345
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 500 IIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKdgEETTVEEIKAFCKGKISHFKIPKYIVFVTNY 579
Cdd:TIGR01923 346 IISGGENIYPEEIETVLYQHPGIQEAVVVPKPDAEWGQVPVAYIVSE--SDISQAKLIAYLTEKLAKYKVPIAFEKLDEL 423
|
490
....*....|...
gi 572879274 580 PLTISGKIQKFKL 592
Cdd:TIGR01923 424 PYNASGKILRNQL 436
|
|
| PLN02860 |
PLN02860 |
o-succinylbenzoate-CoA ligase |
74-600 |
1.75e-58 |
|
o-succinylbenzoate-CoA ligase
Pssm-ID: 215464 [Multi-domain] Cd Length: 563 Bit Score: 205.42 E-value: 1.75e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 74 VGQCLETTAQRvpEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATA-------- 145
Cdd:PLN02860 9 ICQCLTRLATL--RGNAVVTISGNRRRTGHEFVDGVLSLAAGLLRLGLRNGDVVAIAALNSDLYLEWLLAVAcaggivap 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 146 -----------QAMELeyvlkkVGCKALVFPKQfktqqyynvLKQICPEVENAQPGALKSQRLPDLTTVISVDApLPGTL 214
Cdd:PLN02860 87 lnyrwsfeeakSAMLL------VRPVMLVTDET---------CSSWYEELQNDRLPSLMWQVFLESPSSSVFIF-LNSFL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 215 LLDEVVAAGSTRQHLDQlqynqqflsCHDPIN---IQFTSGTTGSPKGATLSHYNIVNNS----NILG---ERLKLHEKt 284
Cdd:PLN02860 151 TTEMLKQRALGTTELDY---------AWAPDDavlICFTSGTTGRPKGVTISHSALIVQSlakiAIVGygeDDVYLHTA- 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 285 peqlrmilpnPLYHcLGSVAGTMMCLMYGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDIL-------NQPDFS 357
Cdd:PLN02860 221 ----------PLCH-IGGLSSALAMLMVGACHVLL-PKFDAKAALQAIKQHNVTSMITVPAMMADLIsltrksmTWKVFP 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 358 SydISTMCGGviaGSPAPPELIRAIINKINMKDLVVAYGTTEN-SPVTFAHFPEDTVEQKAES----------------- 419
Cdd:PLN02860 289 S--VRKILNG---GGSLSSRLLPDAKKLFPNAKLFSAYGMTEAcSSLTFMTLHDPTLESPKQTlqtvnqtksssvhqpqg 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 420 --VGRIMPHTEARIMNMEAGTLAKLNTpgelciRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSK 497
Cdd:PLN02860 364 vcVGKPAPHVELKIGLDESSRVGRILT------RGPHVMLGYWGQNSETASVLSNDGWLDTGDIGWIDKAGNLWLIGRSN 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 498 DMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDG------------EETTV--EEIKAFCKGK 563
Cdd:PLN02860 438 DRIKTGGENVYPEEVEAVLSQHPGVASVVVVGVPDSRLTEMVVACVRLRDGwiwsdnekenakKNLTLssETLRHHCREK 517
|
570 580 590
....*....|....*....|....*....|....*....
gi 572879274 564 -ISHFKIPK-YIVFVTNYPLTISGKIQKFKLREQMERHL 600
Cdd:PLN02860 518 nLSRFKIPKlFVQWRKPFPLTTTGKIRRDEVRREVLSHL 556
|
|
| PRK13391 |
PRK13391 |
acyl-CoA synthetase; Provisional |
82-595 |
2.54e-57 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 184022 [Multi-domain] Cd Length: 511 Bit Score: 201.07 E-value: 2.54e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 82 AQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLG------------MWGPNS----YAWVLMQLATA 145
Cdd:PRK13391 7 AQTTPDKPAVIMASTGEVVTYRELDERSNRLAHLFRSLGLKRGDHVAifmennlrylevCWAAERsglyYTCVNSHLTPA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 146 qamELEYVLKKVGCKALVfpkqfKTQQYYNVlkqiCPEVenaqpgalkSQRLPDLTTVISVDAP--LPGTLLLDEVVAAG 223
Cdd:PRK13391 87 ---EAAYIVDDSGARALI-----TSAAKLDV----ARAL---------LKQCPGVRHRLVLDGDgeLEGFVGYAEAVAGL 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 224 STRQHLDQlqynqqflSCHDPIniQFTSGTTGSPKG--ATLSHYNIVNNSNILGERLKLHEKTPEqLRMILPNPLYHClG 301
Cdd:PRK13391 146 PATPIADE--------SLGTDM--LYSSGTTGRPKGikRPLPEQPPDTPLPLTAFLQRLWGFRSD-MVYLSPAPLYHS-A 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 302 SVAGTMMCLMYGATLILASPiFNGKKALEAISRERGTFLYGTPTMFVDILNQPD--FSSYDISTMCGGVIAGSPAPPELI 379
Cdd:PRK13391 214 PQRAVMLVIRLGGTVIVMEH-FDAEQYLALIEEYGVTHTQLVPTMFSRMLKLPEevRDKYDLSSLEVAIHAAAPCPPQVK 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 380 RAIINKINMkdlVVA--YGTTENSPVTFAHfPEDTVEQKAeSVGRIM---PHtearIMNmEAGTLAKLNTPGELCIRGyC 454
Cdd:PRK13391 293 EQMIDWWGP---IIHeyYAATEGLGFTACD-SEEWLAHPG-TVGRAMfgdLH----ILD-DDGAELPPGEPGTIWFEG-G 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 455 VMLGYWGEPQKTEEAVDQDK-WYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDD 533
Cdd:PRK13391 362 RPFEYLNDPAKTAEARHPDGtWSTVGDIGYVDEDGYLYLTDRAAFMIISGGVNIYPQEAENLLITHPKVADAAVFGVPNE 441
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 572879274 534 RMGEEICACIRLKDGEETTV---EEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:PRK13391 442 DLGEEVKAVVQPVDGVDPGPalaAELIAFCRQRLSRQKCPRSIDFEDELPRLPTGKLYKRLLRDR 506
|
|
| BCL_4HBCL |
cd05959 |
Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate ... |
99-593 |
3.35e-57 |
|
Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Benzoate CoA ligase and 4-hydroxybenzoate-coenzyme A ligase catalyze the first activating step for benzoate and 4-hydroxybenzoate catabolic pathways, respectively. Although these two enzymes share very high sequence homology, they have their own substrate preference. The reaction proceeds via a two-step process; the first ATP-dependent step forms the substrate-AMP intermediate, while the second step forms the acyl-CoA ester, releasing the AMP. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Some bacteria can use benzoic acid or benzenoid compounds as the sole source of carbon and energy through degradation. Benzoate CoA ligase and 4-hydroxybenzoate-Coenzyme A ligase are key enzymes of this process.
Pssm-ID: 341269 [Multi-domain] Cd Length: 508 Bit Score: 200.67 E-value: 3.35e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 99 RLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAW---------------VLMQLATAQamELEYVLKKVGCKALV 163
Cdd:cd05959 29 SLTYAELEAEARRVAGALRALGVKREERVLLIMLDTVDFptaflgairagivpvPVNTLLTPD--DYAYYLEDSRARVVV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 164 fpkqfktqqyynVLKQICPEVENAQPGALksqrlPDLTTVISVDA--PLPGTLLLDEVVAAGSTrqhldqlQYNQQFLSC 241
Cdd:cd05959 107 ------------VSGELAPVLAAALTKSE-----HTLVVLIVSGGagPEAGALLLAELVAAEAE-------QLKPAATHA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 242 HDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGER-LKLHEKTpeqlRMILPNPLYHCLGSVAGTMMCLMYGATLILAS 320
Cdd:cd05959 163 DDPAFWLYSSGSTGRPKGVVHLHADIYWTAELYARNvLGIREDD----VCFSAAKLFFAYGLGNSLTFPLSVGATTVLMP 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 321 PIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMkDLVVAYGTTEN 400
Cdd:cd05959 239 ERPTPAAVFKRIRRYRPTVFFGVPTLYAAMLAAPNLPSRDLSSLRLCVSAGEALPAEVGERWKARFGL-DILDGIGSTEM 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 401 SPVTFAHFPEDTveqKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEeAVDQDKWYWTGD 480
Cdd:cd05959 318 LHIFLSNRPGRV---RYGTTGKPVPGYEVELRD-EDGGDVADGEPGELYVRGPSSATMYWNNRDKTR-DTFQGEWTRTGD 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 481 VATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETT---VEEIK 557
Cdd:cd05959 393 KYVRDDDGFYTYAGRADDMLKVSGIWVSPFEVESALVQHPAVLEAAVVGVEDEDGLTKPKAFVVLRPGYEDSealEEELK 472
|
490 500 510
....*....|....*....|....*....|....*.
gi 572879274 558 AFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 593
Cdd:cd05959 473 EFVKDRLAPYKYPRWIVFVDELPKTATGKIQRFKLR 508
|
|
| MACS_like |
cd05972 |
Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of ... |
100-593 |
1.36e-56 |
|
Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes.
Pssm-ID: 341276 [Multi-domain] Cd Length: 428 Bit Score: 196.79 E-value: 1.36e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 100 LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLAtaqAMELEYVlkkvgckalvfpkqfktqqyynvlkq 179
Cdd:cd05972 1 WSFRELKRESAKAANVLAKLGLRKGDRVAVLLPRVPELWAVILA---VIKLGAV-------------------------- 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 180 ICPEVENAQPGALKsQRLPDLTtvisvdaplPGTLLLDEVvaagstrqhldqlqynqqflschDPINIQFTSGTTGSPKG 259
Cdd:cd05972 52 YVPLTTLLGPKDIE-YRLEAAG---------AKAIVTDAE-----------------------DPALIYFTSGTTGLPKG 98
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 260 ATLSHY----NIVNNSNILGERLK-LHEKTPEqlrmilPNPLYHCLGSVAGTMmcLMYGATLILASPIFNGKKALEAISR 334
Cdd:cd05972 99 VLHTHSyplgHIPTAAYWLGLRPDdIHWNIAD------PGWAKGAWSSFFGPW--LLGATVFVYEGPRFDAERILELLER 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 335 ERGTFLYGTPTMFvDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGTTEnSPVTFAHFPedTVE 414
Cdd:cd05972 171 YGVTSFCGPPTAY-RMLIKQDLSSYKFSHLRLVVSAGEPLNPEVIEWWRAATGLP-IRDGYGQTE-TGLTVGNFP--DMP 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 415 QKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCV--MLGYWGEPQKTEEAVDQDkWYWTGDVATMNEQGFCKI 492
Cdd:cd05972 246 VKPGSMGRPTPGYDVAIID-DDGRELPPGEEGDIAIKLPPPglFLGYVGDPEKTEASIRGD-YYLTGDRAYRDEDGYFWF 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 493 VGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETT---VEEIKAFCKGKISHFKI 569
Cdd:cd05972 324 VGRADDIIKSSGYRIGPFEVESALLEHPAVAEAAVVGSPDPVRGEVVKAFVVLTSGYEPSeelAEELQGHVKKVLAPYKY 403
|
490 500
....*....|....*....|....
gi 572879274 570 PKYIVFVTNYPLTISGKIQKFKLR 593
Cdd:cd05972 404 PREIEFVEELPKTISGKIRRVELR 427
|
|
| PRK06178 |
PRK06178 |
acyl-CoA synthetase; Validated |
72-598 |
2.54e-56 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235724 [Multi-domain] Cd Length: 567 Bit Score: 199.50 E-value: 2.54e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 72 KTVGQCLETTAQRVPEREALVVLHEdvRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLAT------- 144
Cdd:PRK06178 33 RPLTEYLRAWARERPQRPAIIFYGH--VITYAELDELSDRFAALLRQRGVGAGDRVAVFLPNCPQFHIVFFGIlklgavh 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 145 ------AQAMELEYVLKKVGCKALVFPKQFktqqyYNVLKQICPE--VENAQPGALkSQRLPDLTTVisvdaPLPGTLLL 216
Cdd:PRK06178 111 vpvsplFREHELSYELNDAGAEVLLALDQL-----APVVEQVRAEtsLRHVIVTSL-ADVLPAEPTL-----PLPDSLRA 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 217 DEVVAAGSTR--QHLDQL--QYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNN--SNILgerLKLHEKTPEQLRM 290
Cdd:PRK06178 180 PRLAAAGAIDllPALRACtaPVPLPPPALDALAALNYTGGTTGMPKGCEHTQRDMVYTaaAAYA---VAVVGGEDSVFLS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 291 ILPnpLYHCLGSVAGTMMCLMYGATLILASPiFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMcggvia 370
Cdd:PRK06178 257 FLP--EFWIAGENFGLLFPLFSGATLVLLAR-WDAVAFMAAVERYRVTRTVMLVDNAVELMDHPRFAEYDLSSL------ 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 371 gspappELIRAI--INKINM------KDLV------VAYGTTE-NSPVTF-AHFPEDTVEQKAES--VGRIMPHTEARIM 432
Cdd:PRK06178 328 ------RQVRVVsfVKKLNPdyrqrwRALTgsvlaeAAWGMTEtHTCDTFtAGFQDDDFDLLSQPvfVGLPVPGTEFKIC 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 433 NMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAEL 512
Cdd:PRK06178 402 DFETGELLPLGAEGEIVVRTPSLLKGYWNKPEATAEAL-RDGWLHTGDIGKIDEQGFLHYLGRRKEMLKVNGMSVFPSEV 480
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 513 EDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKyIVFVTNYPLTISGKIQKFKL 592
Cdd:PRK06178 481 EALLGQHPAVLGSAVVGRPDPDKGQVPVAFVQLKPGADLTAAALQAWCRENMAVYKVPE-IRIVDALPMTATGKVRKQDL 559
|
....*.
gi 572879274 593 REQMER 598
Cdd:PRK06178 560 QALAEE 565
|
|
| PRK05677 |
PRK05677 |
long-chain-fatty-acid--CoA ligase; Validated |
247-595 |
5.58e-56 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 168170 [Multi-domain] Cd Length: 562 Bit Score: 198.45 E-value: 5.58e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 247 IQFTSGTTGSPKGATLSHYNIVnnSNILGERLKLHEKTPEQLR-MILPNPLYHCLGSVAGTMMCLMYGATLILASPIFNG 325
Cdd:PRK05677 212 LQYTGGTTGVAKGAMLTHRNLV--ANMLQCRALMGSNLNEGCEiLIAPLPLYHIYAFTFHCMAMMLIGNHNILISNPRDL 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 326 KKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDIS----TMCGGvIAGSPAPPELIRAIINKinmkDLVVAYGTTENS 401
Cdd:PRK05677 290 PAMVKELGKWKFSGFVGLNTLFVALCNNEAFRKLDFSalklTLSGG-MALQLATAERWKEVTGC----AICEGYGMTETS 364
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 402 PVTFAHFPEDTveqKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDV 481
Cdd:PRK05677 365 PVVSVNPSQAI---QVGTIGIPVPSTLCKVID-DDGNELPLGEVGELCVKGPQVMKGYWQRPEATDEILDSDGWLKTGDI 440
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 482 ATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCK 561
Cdd:PRK05677 441 ALIQEDGYMRIVDRKKDMILVSGFNVYPNELEDVLAALPGVLQCAAIGVPDEKSGEAIKVFVVVKPGETLTKEQVMEHMR 520
|
330 340 350
....*....|....*....|....*....|....
gi 572879274 562 GKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:PRK05677 521 ANLTGYKVPKAVEFRDELPTTNVGKILRRELRDE 554
|
|
| PRK07788 |
PRK07788 |
acyl-CoA synthetase; Validated |
82-594 |
1.03e-55 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236097 [Multi-domain] Cd Length: 549 Bit Score: 197.46 E-value: 1.03e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 82 AQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQA-------------M 148
Cdd:PRK07788 59 ARRAPDRAALI--DERGTLTYAELDEQSNALARGLLALGVRAGDGVAVLARNHRGFVLALYAAGKVgariillntgfsgP 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 149 ELEYVLKKVGCKALVFPKQFKTqqyynVLKQICPEVenaqPGALKSQRLPDlttviSVDAPLPGTLLLDEVVAAGSTRqh 228
Cdd:PRK07788 137 QLAEVAAREGVKALVYDDEFTD-----LLSALPPDL----GRLRAWGGNPD-----DDEPSGSTDETLDDLIAGSSTA-- 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 229 ldqlqyNQQFLSCHDPINIQfTSGTTGSPKGATLSHYNIVNNSNILGERLKLhektPEQLRMILPNPLYHCLGSVAGTmM 308
Cdd:PRK07788 201 ------PLPKPPKPGGIVIL-TSGTTGTPKGAPRPEPSPLAPLAGLLSRVPF----RAGETTLLPAPMFHATGWAHLT-L 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 309 CLMYGATLILaSPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPD--FSSYDISTMCGGVIAGSPAPPELIRAIINKI 386
Cdd:PRK07788 269 AMALGSTVVL-RRRFDPEATLEDIAKHKATALVVVPVMLSRILDLGPevLAKYDTSSLKIIFVSGSALSPELATRALEAF 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 387 -----NMkdlvvaYGTTENSPVTFAHfPEDTVEQKAeSVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWG 461
Cdd:PRK07788 348 gpvlyNL------YGSTEVAFATIAT-PEDLAEAPG-TVGRPPKGVTVKILD-ENGNEVPRGVVGRIFVGNGFPFEGYTD 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 462 EPQKTEEavdqDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICA 541
Cdd:PRK07788 419 GRDKQII----DGLLSSGDVGYFDEDGLLFVDGRDDDMIVSGGENVFPAEVEDLLAGHPDVVEAAVIGVDDEEFGQRLRA 494
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 572879274 542 CIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 594
Cdd:PRK07788 495 FVVKAPGAALDEDAIKDYVRDNLARYKVPRDVVFLDELPRNPTGKVLKRELRE 547
|
|
| PLN02330 |
PLN02330 |
4-coumarate--CoA ligase-like 1 |
101-596 |
4.24e-55 |
|
4-coumarate--CoA ligase-like 1
Pssm-ID: 215189 [Multi-domain] Cd Length: 546 Bit Score: 195.58 E-value: 4.24e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 101 TFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPN--SYAWVLMQLATAQAmeleyVLKKVGCKALVfpKQFKTQQYYNVLK 178
Cdd:PLN02330 57 TYGEVVRDTRRFAKALRSLGLRKGQVVVVVLPNvaEYGIVALGIMAAGG-----VFSGANPTALE--SEIKKQAEAAGAK 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 179 QICpeVENAQPGALKSQRLPDLTT-VISVDAPLPGTLLLDEVVAAGSTRQHLDQLQynqqflscHDPINIQFTSGTTGSP 257
Cdd:PLN02330 130 LIV--TNDTNYGKVKGLGLPVIVLgEEKIEGAVNWKELLEAADRAGDTSDNEEILQ--------TDLCALPFSSGTTGIS 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 258 KGATLSHYNIVNN--SNILGERlklhektPEQLRMILP---NPLYHCLGsVAGTMMCLMYGATLILASPIFNGKKALEAI 332
Cdd:PLN02330 200 KGVMLTHRNLVANlcSSLFSVG-------PEMIGQVVTlglIPFFHIYG-ITGICCATLRNKGKVVVMSRFELRTFLNAL 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 333 SRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVI--AGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPE 410
Cdd:PLN02330 272 ITQEVSFAPIVPPIILNLVKNPIVEEFDLSKLKLQAImtAAAPLAPELLTAFEAKFPGVQVQEAYGLTEHSCITLTHGDP 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 411 DTVE--QKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQG 488
Cdd:PLN02330 352 EKGHgiAKKNSVGFILPNLEVKFIDPDTGRSLPKNTPGELCVRSQCVMQGYYNNKEETDRTIDEDGWLHTGDIGYIDDDG 431
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 489 FCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFK 568
Cdd:PLN02330 432 DIFIVDRIKELIKYKGFQVAPAELEAILLTHPSVEDAAVVPLPDEEAGEIPAACVVINPKAKESEEDILNFVAANVAHYK 511
|
490 500
....*....|....*....|....*...
gi 572879274 569 IPKYIVFVTNYPLTISGKIQKFKLREQM 596
Cdd:PLN02330 512 KVRVVQFVDSIPKSLSGKIMRRLLKEKM 539
|
|
| ACLS-CaiC |
cd17637 |
acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ... |
243-587 |
1.52e-54 |
|
acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized, but may be similar to Carnitine-CoA ligase (CaiC) which catalyzes the transfer of CoA to carnitine. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341292 [Multi-domain] Cd Length: 333 Bit Score: 188.25 E-value: 1.52e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 243 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCLG-SVAGTMMClMYGATLILASp 321
Cdd:cd17637 1 DPFVIIHTAAVAGRPRGAVLSHGNLIAANLQLIHAMGLTEAD----VYLNMLPLFHIAGlNLALATFH-AGGANVVMEK- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 322 iFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMcgGVIAGSPAPpELIRAIINKINMKdLVVAYGTTENS 401
Cdd:cd17637 75 -FDPAEALELIEEEKVTLMGSFPPILSNLLDAAEKSGVDLSSL--RHVLGLDAP-ETIQRFEETTGAT-FWSLYGQTETS 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 402 -PVTFAHFPEdtveqKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDqDKWYWTGD 480
Cdd:cd17637 150 gLVTLSPYRE-----RPGSAGRPGPLVRVRIVD-DNDRPVPAGETGEIVVRGPLVFQGYWNLPELTAYTFR-NGWHHTGD 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 481 VATMNEQGFCKIVGRS--KDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKA 558
Cdd:cd17637 223 LGRFDEDGYLWYAGRKpeKELIKPGGENVYPAEVEKVILEHPAIAEVCVIGVPDPKWGEGIKAVCVLKPGATLTADELIE 302
|
330 340
....*....|....*....|....*....
gi 572879274 559 FCKGKISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:cd17637 303 FVGSRIARYKKPRYVVFVEALPKTADGSI 331
|
|
| FACL_like_4 |
cd05944 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
250-593 |
3.72e-54 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341266 [Multi-domain] Cd Length: 359 Bit Score: 188.07 E-value: 3.72e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 250 TSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCLGSVAGTMMCLMYGATLILASPI-FNGKKA 328
Cdd:cd05944 10 TGGTTGTPKLAQHTHSNEVYNAWMLALNSLFDPDD----VLLCGLPLFHVNGSVVTLLTPLASGAHVVLAGPAgYRNPGL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 329 LEA----ISRERGTFLYGTPTMFVDILNQPDfsSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGTTENSPVT 404
Cdd:cd05944 86 FDNfwklVERYRITSLSTVPTVYAALLQVPV--NADISSLRFAMSGAAPLPVELRARFEDATGLP-VVEGYGLTEATCLV 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 405 FAHFPEDtvEQKAESVGRIMPHTEARIMNMEAGTLAKL----NTPGELCIRGYCVMLGY-WGEPQKteEAVDQDKWYWTG 479
Cdd:cd05944 163 AVNPPDG--PKRPGSVGLRLPYARVRIKVLDGVGRLLRdcapDEVGEICVAGPGVFGGYlYTEGNK--NAFVADGWLNTG 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 480 DVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAF 559
Cdd:cd05944 239 DLGRLDADGYLFITGRAKDLIIRGGHNIDPALIEEALLRHPAVAFAGAVGQPDAHAGELPVAYVQLKPGAVVEEEELLAW 318
|
330 340 350
....*....|....*....|....*....|....*
gi 572879274 560 CKGKI-SHFKIPKYIVFVTNYPLTISGKIQKFKLR 593
Cdd:cd05944 319 ARDHVpERAAVPKHIEVLEELPVTAVGKVFKPALR 353
|
|
| CBAL |
cd05923 |
4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) ... |
72-596 |
8.88e-54 |
|
4-Chlorobenzoate-CoA ligase (CBAL); CBAL catalyzes the conversion of 4-chlorobenzoate (4-CB) to 4-chlorobenzoyl-coenzyme A (4-CB-CoA) by the two-step adenylation and thioester-forming reactions. 4-Chlorobenzoate (4-CBA) is an environmental pollutant derived from microbial breakdown of aromatic pollutants, such as polychlorinated biphenyls (PCBs), DDT, and certain herbicides. The 4-CBA degrading pathway converts 4-CBA to the metabolite 4-hydroxybezoate (4-HBA), allowing some soil-dwelling microbes to utilize 4-CBA as an alternate carbon source. This pathway consists of three chemical steps catalyzed by 4-CBA-CoA ligase, 4-CBA-CoA dehalogenase, and 4HBA-CoA thioesterase in sequential reactions.
Pssm-ID: 341247 [Multi-domain] Cd Length: 493 Bit Score: 190.80 E-value: 8.88e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 72 KTVGQCLETTAQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLAtaqamele 151
Cdd:cd05923 1 QTVFEMLRRAASRAPDACAIADPARGLRLTYSELRARIEAVAARLHARGLRPGQRVAVVLPNSVEAVIALLA-------- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 152 yvLKKVGC-KALVFPKqfktqqyynvlkqicpevenaqpgaLKSQRLPDL-------TTVISVDA-PLPGT-------LL 215
Cdd:cd05923 73 --LHRLGAvPALINPR-------------------------LKAAELAELiergemtAAVIAVDAqVMDAIfqsgvrvLA 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 216 LDEVVAAGSTRQHLDQLQYNQQflSCHDPINIQFTSGTTGSPKGATLSHYNIVNN----SNILGERLKLHEktpeqlRMI 291
Cdd:cd05923 126 LSDLVGLGEPESAGPLIEDPPR--EPEQPAFVFYTSGTTGLPKGAVIPQRAAESRvlfmSTQAGLRHGRHN------VVL 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 292 LPNPLYHCLGSVAGTMMCLMYGATLILASPiFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAG 371
Cdd:cd05923 198 GLMPLYHVIGFFAVLVAALALDGTYVVVEE-FDPADALKLIEQERVTSLFATPTHLDALAAAAEFAGLKLSSLRHVTFAG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 372 SPAPPELIRAIINKI-NMKdlVVAYGTTENSPVTFAHFPedtveqKAESVGRIMPHTEARIMNMEAGT--LAKLNTPGEL 448
Cdd:cd05923 277 ATMPDAVLERVNQHLpGEK--VNIYGTTEAMNSLYMRDA------RTGTEMRPGFFSEVRIVRIGGSPdeALANGEEGEL 348
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 449 CIR--GYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQ 526
Cdd:cd05923 349 IVAaaADAAFTGYLNQPEATAKKL-QDGWYRTGDVGYVDPSGDVRILGRVDDMIISGGENIHPSEIERVLSRHPGVTEVV 427
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 572879274 527 VVGVKDDRMGEEICACIRLKDGeETTVEEIKAFCK-GKISHFKIPKYIVFVTNYPLTISGKIqkfkLREQM 596
Cdd:cd05923 428 VIGVADERWGQSVTACVVPREG-TLSADELDQFCRaSELADFKRPRRYFFLDELPKNAMNKV----LRRQL 493
|
|
| PRK06164 |
PRK06164 |
acyl-CoA synthetase; Validated |
78-600 |
1.82e-53 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235722 [Multi-domain] Cd Length: 540 Bit Score: 191.11 E-value: 1.82e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALvvLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATA------------ 145
Cdd:PRK06164 16 LDAHARARPDAVAL--IDEDRPLSRAELRALVDRLAAWLAAQGVRRGDRVAVWLPNCIEWVVLFLACArlgatviavntr 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 146 -QAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEVenaqpgalksqrLPDLTTVISVD---APLPGTLLLDEVVA 221
Cdd:PRK06164 94 yRSHEVAHILGRGRARWLVVWPGFKGIDFAAILAAVPPDA------------LPPLRAIAVVDdaaDATPAPAPGARVQL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 222 AGSTRQHLDQLQYNQQflSCHDPINIQFT-SGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCL 300
Cdd:PRK06164 162 FALPDPAPPAAAGERA--ADPDAGALLFTtSGTTSGPKLVLHRQATLLRHARAIARAYGYDPGA----VLLAALPFCGVF 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 301 GsVAGTMMCLMYGATLILaSPIFNGKKALEAISRERGTFLYGTPTMFVDILNQ----PDFSSYDIStmcgGVIAGSPAPP 376
Cdd:PRK06164 236 G-FSTLLGALAGGAPLVC-EPVFDAARTARALRRHRVTHTFGNDEMLRRILDTagerADFPSARLF----GFASFAPALG 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 377 ELIRaiinKINMKDLVVA--YGTTENSPVTFAHFPEDTVEQKAESVGRIM-PHTEARIMNMEAGTLAKLNTPGELCIRGY 453
Cdd:PRK06164 310 ELAA----LARARGVPLTglYGSSEVQALVALQPATDPVSVRIEGGGRPAsPEARVRARDPQDGALLPDGESGEIEIRAP 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 454 CVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVkdD 533
Cdd:PRK06164 386 SLMRGYLDNPDATARALTDDGYFRTGDLGYTRGDGQFVYQTRMGDSLRLGGFLVNPAEIEHALEALPGVAAAQVVGA--T 463
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 572879274 534 RMGEEIC-ACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISG---KIQKFKLREQMERHL 600
Cdd:PRK06164 464 RDGKTVPvAFVIPTDGASPDEAGLMAACREALAGFKVPARVQVVEAFPVTESAngaKIQKHRLREMAQARL 534
|
|
| BACL_like |
cd05929 |
Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes ... |
247-594 |
1.24e-52 |
|
Bacterial Bile acid CoA ligases and similar proteins; Bile acid-Coenzyme A ligase catalyzes the formation of bile acid-CoA conjugates in a two-step reaction: the formation of a bile acid-AMP molecule as an intermediate, followed by the formation of a bile acid-CoA. This ligase requires a bile acid with a free carboxyl group, ATP, Mg2+, and CoA for synthesis of the final bile acid-CoA conjugate. The bile acid-CoA ligation is believed to be the initial step in the bile acid 7alpha-dehydroxylation pathway in the intestinal bacterium Eubacterium sp.
Pssm-ID: 341252 [Multi-domain] Cd Length: 473 Bit Score: 187.20 E-value: 1.24e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 247 IQFTSGTTGSPKG--ATLSHyNIVNNSNILGERLKLhEKTPEQlRMILPNPLYHCLGSVAgTMMCLMYGATLILAsPIFN 324
Cdd:cd05929 130 MLYSGGTTGRPKGikRGLPG-GPPDNDTLMAAALGF-GPGADS-VYLSPAPLYHAAPFRW-SMTALFMGGTLVLM-EKFD 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 325 GKKALEAISRERGTFLYGTPTMFVDILNQPD--FSSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGTTENSP 402
Cdd:cd05929 205 PEEFLRLIERYRVTFAQFVPTMFVRLLKLPEavRNAYDLSSLKRVIHAAAPCPPWVKEQWIDWGGPI-IWEYYGGTEGQG 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 403 VTFAHfPEDTVEQKAeSVGRIMpHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLgYWGEPQKTEEAVDQDKWYWTGDVA 482
Cdd:cd05929 284 LTIIN-GEEWLTHPG-SVGRAV-LGKVHILD-EDGNEVPPGEIGEVYFANGPGFE-YTNDPEKTAAARNEGGWSTLGDVG 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 483 TMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTV---EEIKAF 559
Cdd:cd05929 359 YLDEDGYLYLTDRRSDMIISGGVNIYPQEIENALIAHPKVLDAAVVGVPDEELGQRVHAVVQPAPGADAGTalaEELIAF 438
|
330 340 350
....*....|....*....|....*....|....*
gi 572879274 560 CKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 594
Cdd:cd05929 439 LRDRLSRYKCPRSIEFVAELPRDDTGKLYRRLLRD 473
|
|
| FACL_like_6 |
cd05922 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
191-593 |
1.41e-52 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341246 [Multi-domain] Cd Length: 457 Bit Score: 186.49 E-value: 1.41e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 191 ALKSQRLPDLTTVISVDAPLPGT-LLLDEVVAAGSTRQhldqlqynqQFLSCH-DPINIQFTSGTTGSPKGATLSHYNIV 268
Cdd:cd05922 73 VLADAGAADRLRDALPASPDPGTvLDADGIRAARASAP---------AHEVSHeDLALLLYTSGSTGSPKLVRLSHQNLL 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 269 NNSNILGERLKLHEKTPEQLRMilpnPLYHCLG-SVAGTMmcLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMF 347
Cdd:cd05922 144 ANARSIAEYLGITADDRALTVL----PLSYDYGlSVLNTH--LLRGATLVLTNDGVLDDAFWEDLREHGATGLAGVPSTY 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 348 vDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPvTFAHFPEDTVEQKAESVGRIMPHT 427
Cdd:cd05922 218 -AMLTRLGFDPAKLPSLRYLTQAGGRLPQETIARLRELLPGAQVYVMYGQTEATR-RMTYLPPERILEKPGSIGLAIPGG 295
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 428 EARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENI 507
Cdd:cd05922 296 EFEILD-DDGTPTPPGEPGEIVHRGPNVMKGYWNDPPYRRKEGRGGGVLHTGDLARRDEDGFLFIVGRRDRMIKLFGNRI 374
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 508 YPAELEDFFHTHPKVQEVQVVGVkDDRMGEEICACIRLKDGEEttVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:cd05922 375 SPTEIEAAARSIGLIIEAAAVGL-PDPLGEKLALFVTAPDKID--PKDVLRSLAERLPPYKVPATVRVVDELPLTASGKV 451
|
....*.
gi 572879274 588 QKFKLR 593
Cdd:cd05922 452 DYAALR 457
|
|
| BCL_like |
cd05919 |
Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate ... |
93-593 |
3.33e-52 |
|
Benzoate CoA ligase (BCL) and similar adenylate forming enzymes; This family contains benzoate CoA ligase (BCL) and related ligases that catalyze the acylation of benzoate derivatives, 2-aminobenzoate and 4-hydroxybenzoate. Aromatic compounds represent the second most abundant class of organic carbon compounds after carbohydrates. Xenobiotic aromatic compounds are also a major class of man-made pollutants. Some bacteria use benzoate as the sole source of carbon and energy through benzoate degradation. Benzoate degradation starts with its activation to benzoyl-CoA by benzoate CoA ligase. The reaction catalyzed by benzoate CoA ligase proceeds via a two-step process; the first ATP-dependent step forms an acyl-AMP intermediate, and the second step forms the acyl-CoA ester with release of the AMP.
Pssm-ID: 341243 [Multi-domain] Cd Length: 436 Bit Score: 184.97 E-value: 3.33e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 93 VLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAqameleyvlkKVGCKALVFPKQFKTQQ 172
Cdd:cd05919 4 FYAADRSVTYGQLHDGANRLGSALRNLGVSSGDRVLLLMLDSPELVQLFLGCL----------ARGAIAVVINPLLHPDD 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 173 YYNVLKqicpeveNAQPGALksqrlpdlttVISVDAplpgtllldevvaagstrqhLDQLQYnqqflschdpiniqfTSG 252
Cdd:cd05919 74 YAYIAR-------DCEARLV----------VTSADD--------------------IAYLLY---------------SSG 101
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 253 TTGSPKGATLSHYNIVNNSNILG-ERLKLhekTPEQLRMILPNpLYHCLGSVAGTMMCLMYGATLILASPIFNGKKALEA 331
Cdd:cd05919 102 TTGPPKGVMHAHRDPLLFADAMArEALGL---TPGDRVFSSAK-MFFGYGLGNSLWFPLAVGASAVLNPGWPTAERVLAT 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 332 ISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRA--------IINKInmkdlvvayGTTENSPV 403
Cdd:cd05919 178 LARFRPTVLYGVPTFYANLLDSCAGSPDALRSLRLCVSAGEALPRGLGERwmehfggpILDGI---------GATEVGHI 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 404 TFAHFPEDTveqKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVAT 483
Cdd:cd05919 249 FLSNRPGAW---RLGSTGRPVPGYEIRLVD-EEGHTIPPGEEGDLLVRGPSAAVGYWNNPEKSRATF-NGGWYRTGDKFC 323
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 484 MNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDG---EETTVEEIKAFC 560
Cdd:cd05919 324 RDADGWYTHAGRADDMLKVGGQWVSPVEVESLIIQHPAVAEAAVVAVPESTGLSRLTAFVVLKSPaapQESLARDIHRHL 403
|
490 500 510
....*....|....*....|....*....|...
gi 572879274 561 KGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 593
Cdd:cd05919 404 LERLSAHKVPRRIAFVDELPRTATGKLQRFKLR 436
|
|
| PRK07798 |
PRK07798 |
acyl-CoA synthetase; Validated |
73-586 |
4.91e-52 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236100 [Multi-domain] Cd Length: 533 Bit Score: 187.01 E-value: 4.91e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 73 TVGQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAM---- 148
Cdd:PRK07798 4 NIADLFEAVADAVPDRVALV--CGDRRLTYAELEERANRLAHYLIAQGLGPGDHVGIYARNRIEYVEAMLGAFKARavpv 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 149 ---------ELEYVLKKVGCKALVFPKQFktqqyynvlkqiCPEVENAQPgalksqRLPDLTTVISVD-----APLPGTL 214
Cdd:PRK07798 82 nvnyryvedELRYLLDDSDAVALVYEREF------------APRVAEVLP------RLPKLRTLVVVEdgsgnDLLPGAV 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 215 LLDEVVAAGSTRQHLDQlqynqqflSCHDPINIQFTSGTTGSPKGATLSHYNI---------------VNNSNILGERLK 279
Cdd:PRK07798 144 DYEDALAAGSPERDFGE--------RSPDDLYLLYTGGTTGMPKGVMWRQEDIfrvllggrdfatgepIEDEEELAKRAA 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 280 lheKTPEQLRMILPnPLYHCLGSVAgTMMCLMYGATLILAS-PIFNGKKALEAISRERGTFL------YGTPtmFVDILN 352
Cdd:PRK07798 216 ---AGPGMRRFPAP-PLMHGAGQWA-AFAALFSGQTVVLLPdVRFDADEVWRTIEREKVNVItivgdaMARP--LLDALE 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 353 QPDfsSYDISTMcgGVIAGSPAP--PE----LIRAIINKInmkdLVVAYGTTE---NSPVTFAHFPEDTVEQK------- 416
Cdd:PRK07798 289 ARG--PYDLSSL--FAIASGGALfsPSvkeaLLELLPNVV----LTDSIGSSEtgfGGSGTVAKGAVHTGGPRftigprt 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 417 ---AESVGRIMPHTEARimnmeaGTLAKlntpgelciRGYcVMLGYWGEPQKTEEA---VDQDKWYWTGDVATMNEQGFC 490
Cdd:PRK07798 361 vvlDEDGNPVEPGSGEI------GWIAR---------RGH-IPLGYYKDPEKTAETfptIDGVRYAIPGDRARVEADGTI 424
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 491 KIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIP 570
Cdd:PRK07798 425 TLLGRGSVCINTGGEKVFPEEVEEALKAHPDVADALVVGVPDERWGQEVVAVVQLREGARPDLAELRAHCRSSLAGYKVP 504
|
570
....*....|....*.
gi 572879274 571 KYIVFVTNYPLTISGK 586
Cdd:PRK07798 505 RAIWFVDEVQRSPAGK 520
|
|
| OSB_MenE-like |
cd17630 |
O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) ... |
243-594 |
1.23e-51 |
|
O-succinylbenzoic acid-CoA ligase; This family contains O-succinylbenzoyl-CoA (OSB-CoA) synthetase (also known as O-succinylbenzoic acid CoA ligase) that belongs to the ANL superfamily and catalyzes the ligation of CoA to o-succinylbenzoate (OSB). It includes MenE in the bacterial menaquinone biosynthesis pathway which is a promising target for the development of novel antibacterial agents. MenE catalyzes CoA ligation via an acyl-adenylate intermediate; tight-binding inhibitors of MenE based on stable acyl-sulfonyladenosine analogs of this intermediate provide a pathway toward the development of optimized MenE inhibitors.
Pssm-ID: 341285 [Multi-domain] Cd Length: 325 Bit Score: 180.22 E-value: 1.23e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 243 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHclgsVAGTMM---CLMYGATLILA 319
Cdd:cd17630 1 RLATVILTSGSTGTPKAVVHTAANLLASAAGLHSRLGFGGGD----SWLLSLPLYH----VGGLAIlvrSLLAGAELVLL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 320 SPifngkKALEAISRERG--TFLYGTPTMFVDILnQPDFSSYDISTMCGGVIAGSPAPPEL-IRAIINKINmkdLVVAYG 396
Cdd:cd17630 73 ER-----NQALAEDLAPPgvTHVSLVPTQLQRLL-DSGQGPAALKSLRAVLLGGAPIPPELlERAADRGIP---LYTTYG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 397 TTENSPVTFAHFPEDTveqKAESVGRIMPHTEARIMNmeagtlaklntPGELCIRGYCVMLGYWGEPqkTEEAVDQDKWY 476
Cdd:cd17630 144 MTETASQVATKRPDGF---GRGGVGVLLPGRELRIVE-----------DGEIWVGGASLAMGYLRGQ--LVPEFNEDGWF 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 477 WTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDgeETTVEEI 556
Cdd:cd17630 208 TTKDLGELHADGRLTVLGRADNMIISGGENIQPEEIEAALAAHPAVRDAFVVGVPDEELGQRPVAVIVGRG--PADPAEL 285
|
330 340 350
....*....|....*....|....*....|....*...
gi 572879274 557 KAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 594
Cdd:cd17630 286 RAWLKDKLARFKLPKRIYPVPELPRTGGGKVDRRALRA 323
|
|
| PRK06155 |
PRK06155 |
crotonobetaine/carnitine-CoA ligase; Provisional |
45-595 |
1.25e-51 |
|
crotonobetaine/carnitine-CoA ligase; Provisional
Pssm-ID: 235719 [Multi-domain] Cd Length: 542 Bit Score: 186.12 E-value: 1.25e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 45 REVDRMVSTPIGGLSyvqgctkkhLNSKTVGQCLETTAQRVPEREALVVlhEDVRLTFAQLKEEVDKAASGLLSIGLCKG 124
Cdd:PRK06155 3 PLGAGLAARAVDPLP---------PSERTLPAMLARQAERYPDRPLLVF--GGTRWTYAEAARAAAAAAHALAAAGVKRG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 125 DRLGMWGPN---------SYAW---VLMQLATA-QAMELEYVLKKVGCKALVfpkqfktqqyynVLKQICPEVENAQPGA 191
Cdd:PRK06155 72 DRVALMCGNriefldvflGCAWlgaIAVPINTAlRGPQLEHILRNSGARLLV------------VEAALLAALEAADPGD 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 192 LKSQR--LPDLTTVISVDA-----PLPGtllLDEVVAAGSTRQHldqlqynqqflschDPINIQFTSGTTGSPKGATLSH 264
Cdd:PRK06155 140 LPLPAvwLLDAPASVSVPAgwstaPLPP---LDAPAPAAAVQPG--------------DTAAILYTSGTTGPSKGVCCPH 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 265 YNIVNNSNILGERLKLHEKtpEQLRMILpnPLYHcLGSVAGTMMCLMYGATLILaSPIFNGKKALEAISRERGTFLYGTP 344
Cdd:PRK06155 203 AQFYWWGRNSAEDLEIGAD--DVLYTTL--PLFH-TNALNAFFQALLAGATYVL-EPRFSASGFWPAVRRHGATVTYLLG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 345 TMFVDILNQPDFSSYDISTMcggVIAGSPA-PPELIRAIINKINMkDLVVAYGTTE-NSPVTFAHfpedtVEQKAESVGR 422
Cdd:PRK06155 277 AMVSILLSQPARESDRAHRV---RVALGPGvPAALHAAFRERFGV-DLLDGYGSTEtNFVIAVTH-----GSQRPGSMGR 347
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 423 IMPHTEARIMNmEAGTLAKLNTPGELCIRG---YCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDM 499
Cdd:PRK06155 348 LAPGFEARVVD-EHDQELPDGEPGELLLRAdepFAFATGYFGMPEKTVEAW-RNLWFHTGDRVVRDADGWFRFVDRIKDA 425
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 500 IIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNY 579
Cdd:PRK06155 426 IRRRGENISSFEVEQVLLSHPAVAAAAVFPVPSELGEDEVMAAVVLRDGTALEPVALVRHCEPRLAYFAVPRYVEFVAAL 505
|
570
....*....|....*.
gi 572879274 580 PLTISGKIQKFKLREQ 595
Cdd:PRK06155 506 PKTENGKVQKFVLREQ 521
|
|
| AFD_YhfT-like |
cd17633 |
fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, ... |
243-587 |
2.10e-51 |
|
fatty acid-CoA ligase VraA; This family of acyl-CoA ligases includes Bacillus subtilis YhfT, as well as long-chain fatty acid-CoA ligase VraA, all of which are as yet to be characterized. These proteins belong to the adenylate-forming enzymes which catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain
Pssm-ID: 341288 [Multi-domain] Cd Length: 320 Bit Score: 179.52 E-value: 2.10e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 243 DPINIQFTSGTTGSPKGATLSHYNIVNnSNILGERLkLHEKTPEqlRMILPNPLYHCLgSVAGTMMCLMYGATLILASpI 322
Cdd:cd17633 1 NPFYIGFTSGTTGLPKAYYRSERSWIE-SFVCNEDL-FNISGED--AILAPGPLSHSL-FLYGAISALYLGGTFIGQR-K 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 323 FNGKKALEAISRERGTFLYGTPTMfVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINmkdLVVAYGTTENSP 402
Cdd:cd17633 75 FNPKSWIRKINQYNATVIYLVPTM-LQALARTLEPESKIKSIFSSGQKLFESTKKKLKNIFPKAN---LIEFYGTSELSF 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 403 VTFaHFPEDtvEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVmlgywgepqktEEAVDQDKWYWTGDVA 482
Cdd:cd17633 151 ITY-NFNQE--SRPPNSVGRPFPNVEIEIRNADGGEIGKIFVKSEMVFSGYVR-----------GGFSNPDGWMSVGDIG 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 483 TMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRlkdGEETTVEEIKAFCKG 562
Cdd:cd17633 217 YVDEEGYLYLVGRESDMIIIGGINIFPTEIESVLKAIPGIEEAIVVGIPDARFGEIAVALYS---GDKLTYKQLKRFLKQ 293
|
330 340
....*....|....*....|....*
gi 572879274 563 KISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:cd17633 294 KLSRYEIPKKIIFVDSLPYTSSGKI 318
|
|
| PLN02246 |
PLN02246 |
4-coumarate--CoA ligase |
77-597 |
3.43e-51 |
|
4-coumarate--CoA ligase
Pssm-ID: 215137 [Multi-domain] Cd Length: 537 Bit Score: 184.80 E-value: 3.43e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 77 CLETTAQrVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLA---------TAQA 147
Cdd:PLN02246 29 CFERLSE-FSDRPCLIDGATGRVYTYADVELLSRRVAAGLHKLGIRQGDVVMLLLPNCPEFVLAFLGasrrgavttTANP 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 148 M----ELEYVLKKVGCKALVfpkqfkTQ-QYYNVLKQICPEvenaqpgalksqrlpDLTTVISVDAPLPGTLLLDEVVAA 222
Cdd:PLN02246 108 FytpaEIAKQAKASGAKLII------TQsCYVDKLKGLAED---------------DGVTVVTIDDPPEGCLHFSELTQA 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 223 GSTRqhLDQLQYNQQflschDPINIQFTSGTTGSPKGATLSHYNIVNN--SNILGERLKLHEKTPEQLRMILPnpLYH-- 298
Cdd:PLN02246 167 DENE--LPEVEISPD-----DVVALPYSSGTTGLPKGVMLTHKGLVTSvaQQVDGENPNLYFHSDDVILCVLP--MFHiy 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 299 CLGSVagtMMC-LMYGATlILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMcGGVIAG-SPAPP 376
Cdd:PLN02246 238 SLNSV---LLCgLRVGAA-ILIMPKFEIGALLELIQRHKVTIAPFVPPIVLAIAKSPVVEKYDLSSI-RMVLSGaAPLGK 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 377 ELIRAIINKINMKDLVVAYGTTENSPV-----TFAHFPEDTveqKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIR 451
Cdd:PLN02246 313 ELEDAFRAKLPNAVLGQGYGMTEAGPVlamclAFAKEPFPV---KSGSCGTVVRNAELKIVDPETGASLPRNQPGEICIR 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 452 GYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVK 531
Cdd:PLN02246 390 GPQIMKGYLNDPEATANTIDKDGWLHTGDIGYIDDDDELFIVDRLKELIKYKGFQVAPAELEALLISHPSIADAAVVPMK 469
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 572879274 532 DDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQME 597
Cdd:PLN02246 470 DEVAGEVPVAFVVRSNGSEITEDEIKQFVAKQVVFYKRIHKVFFVDSIPKAPSGKILRKDLRAKLA 535
|
|
| A_NRPS |
cd05930 |
The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain ... |
86-587 |
7.05e-50 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341253 [Multi-domain] Cd Length: 444 Bit Score: 178.88 E-value: 7.05e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 86 PEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLAtaqameleyVLKkVGCkALV-- 163
Cdd:cd05930 1 PDAVAVV--DGDQSLTYAELDARANRLARYLRERGVGPGDLVAVLLERSLEMVVAILA---------VLK-AGA-AYVpl 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 164 ---FPKQfktqqyynVLKQIcpeVENAQPgalksqrlpdlttvisvdaplpgTLLLDevvaagstrqHLDQLQYnqqfls 240
Cdd:cd05930 68 dpsYPAE--------RLAYI---LEDSGA-----------------------KLVLT----------DPDDLAY------ 97
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 241 chdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEktpeQLRMILPNPLYHCLgSVAGTMMCLMYGATLILAS 320
Cdd:cd05930 98 ------VIYTSGSTGKPKGVMVEHRGLVNLLLWMQEAYPLTP----GDRVLQFTSFSFDV-SVWEIFGALLAGATLVVLP 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 321 P--IFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSsydistMCGG----VIAGSPAPPELIRAIINKINMKDLVVA 394
Cdd:cd05930 167 EevRKDPEALADLLAEEGITVLHLTPSLLRLLLQELELA------ALPSlrlvLVGGEALPPDLVRRWRELLPGARLVNL 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 395 YGTTENS-PVTFAHFPEDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQD 473
Cdd:cd05930 241 YGPTEATvDATYYRVPPDDEEDGRVPIGRPIPNTRVYVLD-ENLRPVPPGVPGELYIGGAGLARGYLNRPELTAERFVPN 319
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 474 KW------YWTGDVATMNEQGFCKIVGRSKDMI-IRGgeniY---PAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACI 543
Cdd:cd05930 320 PFgpgermYRTGDLVRWLPDGNLEFLGRIDDQVkIRG----YrieLGEIEAALLAHPGVREAAVVAREDGDGEKRLVAYV 395
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 572879274 544 RLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:cd05930 396 VPDEGGELDEEELRAHLAERLPDYMVPSAFVVLDALPLTPNGKV 439
|
|
| AAS_C |
cd05909 |
C-terminal domain of the acyl-acyl carrier protein synthetase (also called ... |
234-587 |
7.48e-50 |
|
C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Acyl-acyl carrier protein synthase (Aas) is a membrane protein responsible for a minor pathway of incorporating exogenous fatty acids into membrane phospholipids. Its in vitro activity is characterized by the ligation of free fatty acids between 8 and 18 carbons in length to the acyl carrier protein sulfydryl group (ACP-SH) in the presence of ATP and Mg2+. However, its in vivo function is as a 2-acylglycerophosphoethanolamine (2-acyl-GPE) acyltransferase. The reaction occurs in two steps: the acyl chain is first esterified to acyl carrier protein (ACP) via a thioester bond, followed by a second step where the acyl chain is transferred to a 2-acyllysophospholipid, thus completing the transacylation reaction. This model represents the C-terminal domain of the enzyme, which belongs to the class I adenylate-forming enzyme family, including acyl-CoA synthetases.
Pssm-ID: 341235 [Multi-domain] Cd Length: 490 Bit Score: 179.83 E-value: 7.48e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 234 YNQQFLSC---HDPINIQFTSGTTGSPKGATLSHYNIVNNSnilgERLKLHEKTPEQLRMILPNPLYHCLGSVAGTMMCL 310
Cdd:cd05909 136 LRIFGVAPvqpDDPAVILFTSGSEGLPKGVVLSHKNLLANV----EQITAIFDPNPEDVVFGALPFFHSFGLTGCLWLPL 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 311 MYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPdfSSYDISTMcGGVIAGSPAPPELIRAIINKINMKD 390
Cdd:cd05909 212 LSGIKVVFHPNPLDYKKIPELIYDKKATILLGTPTFLRGYARAA--HPEDFSSL-RLVVAGAEKLKDTLRQEFQEKFGIR 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 391 LVVAYGTTENSPVTFAHFPEdtVEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAV 470
Cdd:cd05909 289 ILEGYGTTECSPVISVNTPQ--SPNKEGTVGRPLPGMEVKIVSVETHEEVPIGEGGLLLVRGPNVMLGYLNEPELTSFAF 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 471 dQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTH-PKVQEVQVVGVKDDRMGEEICACIrlkDGE 549
Cdd:cd05909 367 -GDGWYDTGDIGKIDGEGFLTITGRLSRFAKIAGEMVSLEAIEDILSEIlPEDNEVAVVSVPDGRKGEKIVLLT---TTT 442
|
330 340 350
....*....|....*....|....*....|....*....
gi 572879274 550 ETTVEEIKAFCK-GKISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:cd05909 443 DTDPSSLNDILKnAGISNLAKPSYIHQVEEIPLLGTGKP 481
|
|
| 23DHB-AMP_lg |
cd05920 |
2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2, ... |
72-589 |
3.07e-49 |
|
2,3-dihydroxybenzoate-AMP ligase; 2,3-dihydroxybenzoate-AMP ligase activates 2,3-dihydroxybenzoate (DHB) by ligation of AMP from ATP with the release of pyrophosphate. However, it can also catalyze the ATP-PPi exchange for 2,3-DHB analogs, such as salicyclic acid (o-hydrobenzoate), as well as 2,4-DHB and 2,5-DHB, but with less efficiency. Proteins in this family are the stand-alone adenylation components of non-ribosomal peptide synthases (NRPSs) involved in the biosynthesis of siderophores, which are low molecular weight iron-chelating compounds synthesized by many bacteria to aid in the acquisition of this vital trace elements. In Escherichia coli, the 2,3-dihydroxybenzoate-AMP ligase is called EntE, the adenylation component of the enterobactin NRPS system.
Pssm-ID: 341244 [Multi-domain] Cd Length: 482 Bit Score: 178.29 E-value: 3.07e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 72 KTVGQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRlgmwgpnsyawVLMQLA-TAQAMEL 150
Cdd:cd05920 15 EPLGDLLARSAARHPDRIAVV--DGDRRLTYRELDRRADRLAAGLRGLGIRPGDR-----------VVVQLPnVAEFVVL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 151 EYVLKKVGckalVFPkqfktqqyynVLkqicpevenaqpgALKSQRLPDLTTVISVDAPLpgtllldEVVAAGSTRQHLD 230
Cdd:cd05920 82 FFALLRLG----AVP----------VL-------------ALPSHRRSELSAFCAHAEAV-------AYIVPDRHAGFDH 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 231 QLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSH----YNIVNNSNILGerlkLHEKTpeqlRMILPNPLYH-----CLG 301
Cdd:cd05920 128 RALARELAESIPEVALFLLSGGTTGTPKLIPRTHndyaYNVRASAEVCG----LDQDT----VYLAVLPAAHnfplaCPG 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 302 sVAGTMMClmyGATLILASPIfNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRA 381
Cdd:cd05920 200 -VLGTLLA---GGRVVLAPDP-SPDAAFPLIEREGVTVTALVPALVSLWLDAAASRRADLSSLRLLQVGGARLSPALARR 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 382 IINKINMKdLVVAYGTTENSpVTFAHFpEDTVEQKAESVGRIM-PHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYW 460
Cdd:cd05920 275 VPPVLGCT-LQQVFGMAEGL-LNYTRL-DDPDEVIIHTQGRPMsPDDEIRVVD-EEGNPVPPGEEGELLTRGPYTIRGYY 350
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 461 GEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEIC 540
Cdd:cd05920 351 RAPEHNARAFTPDGFYRTGDLVRRTPDGYLVVEGRIKDQINRGGEKIAAEEVENLLLRHPAVHDAAVVAMPDELLGERSC 430
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|
gi 572879274 541 ACIRLKDgEETTVEEIKAFCKGK-ISHFKIPKYIVFVTNYPLTISGKIQK 589
Cdd:cd05920 431 AFVVLRD-PPPSAAQLRRFLRERgLAAYKLPDRIEFVDSLPLTAVGKIDK 479
|
|
| PRK07638 |
PRK07638 |
acyl-CoA synthetase; Validated |
242-597 |
1.05e-48 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236071 [Multi-domain] Cd Length: 487 Bit Score: 176.89 E-value: 1.05e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 242 HDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQlRMILPNPLYHCLgSVAGTMMCLMYGATLILAsP 321
Cdd:PRK07638 143 NAPFYMGFTSGSTGKPKAFLRAQQSWLHSFDCNVHDFHM---KRED-SVLIAGTLVHSL-FLYGAISTLYVGQTVHLM-R 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 322 IFNGKKALEAISRERGTFLYGTPTM---FVDILNQPDFSSYDISTmcggviaGSPAPPELIRAIINKINMKDLVVAYGTT 398
Cdd:PRK07638 217 KFIPNQVLDKLETENISVMYTVPTMlesLYKENRVIENKMKIISS-------GAKWEAEAKEKIKNIFPYAKLYEFYGAS 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 399 ENSPVTFAHfPEDTvEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEaVDQDKWYWT 478
Cdd:PRK07638 290 ELSFVTALV-DEES-ERRPNSVGRPFHNVQVRICN-EAGEEVQKGEIGTVYVKSPQFFMGYIIGGVLARE-LNADGWMTV 365
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 479 GDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIrlkDGEEtTVEEIKA 558
Cdd:PRK07638 366 RDVGYEDEEGFIYIVGREKNMILFGGINIFPEEIESVLHEHPAVDEIVVIGVPDSYWGEKPVAII---KGSA-TKQQLKS 441
|
330 340 350
....*....|....*....|....*....|....*....
gi 572879274 559 FCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQME 597
Cdd:PRK07638 442 FCLQRLSSFKIPKEWHFVDEIPYTNSGKIARMEAKSWIE 480
|
|
| PRK07514 |
PRK07514 |
malonyl-CoA synthase; Validated |
247-595 |
3.15e-48 |
|
malonyl-CoA synthase; Validated
Pssm-ID: 181011 [Multi-domain] Cd Length: 504 Bit Score: 175.83 E-value: 3.15e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 247 IQFTSGTTGSPKGATLSHYNIVNNSnilgerLKLHEK---TPEQlRMILPNPLYHCLGSVAGTMMCLMYGATLILAsPIF 323
Cdd:PRK07514 161 ILYTSGTTGRSKGAMLSHGNLLSNA------LTLVDYwrfTPDD-VLIHALPIFHTHGLFVATNVALLAGASMIFL-PKF 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 324 NGKKALEAIsrERGTFLYGTPTMFVDILNQPDFSSydisTMCGGV---IAGSpAP--PELIR--------AIINKinmkd 390
Cdd:PRK07514 233 DPDAVLALM--PRATVMMGVPTFYTRLLQEPRLTR----EAAAHMrlfISGS-APllAETHRefqertghAILER----- 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 391 lvvaYGTTENSPVTfaHFPEDTvEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAV 470
Cdd:PRK07514 301 ----YGMTETNMNT--SNPYDG-ERRAGTVGFPLPGVSLRVTDPETGAELPPGEIGMIEVKGPNVFKGYWRMPEKTAEEF 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 471 DQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEE 550
Cdd:PRK07514 374 RADGFFITGDLGKIDERGYVHIVGRGKDLIISGGYNVYPKEVEGEIDELPGVVESAVIGVPHPDFGEGVTAVVVPKPGAA 453
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 572879274 551 TTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:PRK07514 454 LDEAAILAALKGRLARFKQPKRVFFVDELPRNTMGKVQKNLLREQ 498
|
|
| PRK07008 |
PRK07008 |
long-chain-fatty-acid--CoA ligase; Validated |
249-599 |
4.06e-47 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 235908 [Multi-domain] Cd Length: 539 Bit Score: 173.35 E-value: 4.06e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 249 FTSGTTGSPKGATLSHYNIVnnsnilgerlkLH---EKTPEQLRM-----ILP-NPLYHCLG-----SVAgtmmclMYGA 314
Cdd:PRK07008 183 YTSGTTGNPKGALYSHRSTV-----------LHaygAALPDAMGLsardaVLPvVPMFHVNAwglpySAP------LTGA 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 315 TLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVA 394
Cdd:PRK07008 246 KLVLPGPDLDGKSLYELIEAERVTFSAGVPTVWLGLLNHMREAGLRFSTLRRTVIGGSACPPAMIRTFEDEYGVE-VIHA 324
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 395 YGTTENSPV------TFAH--FPEDTVEQKAESVGRIMPHTEARIMNMEAGTL---AKlnTPGELCIRGYCVMLGYWgep 463
Cdd:PRK07008 325 WGMTEMSPLgtlcklKWKHsqLPLDEQRKLLEKQGRVIYGVDMKIVGDDGRELpwdGK--AFGDLQVRGPWVIDRYF--- 399
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 464 qKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACI 543
Cdd:PRK07008 400 -RGDASPLVDGWFPTGDVATIDADGFMQITDRSKDVIKSGGEWISSIDIENVAVAHPAVAEAACIACAHPKWDERPLLVV 478
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 572879274 544 RLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMERH 599
Cdd:PRK07008 479 VKRPGAEVTREELLAFYEGKVAKWWIPDDVVFVDAIPHTATGKLQKLKLREQFRDY 534
|
|
| ABCL |
cd05958 |
2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate ... |
247-593 |
1.24e-46 |
|
2-aminobenzoate-CoA ligase (ABCL); ABCL catalyzes the initial step in the 2-aminobenzoate aerobic degradation pathway by activating 2-aminobenzoate to 2-aminobenzoyl-CoA. The reaction is carried out via a two-step process; the first step is ATP-dependent and forms a 2-aminobenzoyl-AMP intermediate, and the second step forms the 2-aminobenzoyl-CoA ester and releases the AMP. 2-Aminobenzoyl-CoA is further converted to 2-amino-5-oxo-cyclohex-1-ene-1-carbonyl-CoA catalyzed by 2-aminobenzoyl-CoA monooxygenase/reductase. ABCL has been purified from cells aerobically grown with 2-aminobenzoate as sole carbon, energy, and nitrogen source, and has been characterized as a monomer.
Pssm-ID: 341268 [Multi-domain] Cd Length: 439 Bit Score: 169.97 E-value: 1.24e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 247 IQFTSGTTGSPKGATLSHYNIVNNS-----NILGERlklhektpEQLRMILPNPLYHCLGsVAGTMMCLMY-GATLIL-- 318
Cdd:cd05958 102 LAFTSGTTGAPKATMHFHRDPLASAdryavNVLRLR--------EDDRFVGSPPLAFTFG-LGGVLLFPFGvGASGVLle 172
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 319 -ASPifngKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMkDLVVAYGT 397
Cdd:cd05958 173 eATP----DLLLSAIARYKPTVLFTAPTAYRAMLAHPDAAGPDLSSLRKCVSAGEALPAALHRAWKEATGI-PIIDGIGS 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 398 TENSPVTFAHFPEDTveqKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCvmlGYWGEPQKTEEAVDQDKWYW 477
Cdd:cd05958 248 TEMFHIFISARPGDA---RPGATGKPVPGYEAKVVD-DEGNPVPDGTIGRLAVRGPT---GCRYLADKRQRTYVQGGWNI 320
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 478 TGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGE---ETTVE 554
Cdd:cd05958 321 TGDTYSRDPDGYFRHQGRSDDMIVSGGYNIAPPEVEDVLLQHPAVAECAVVGHPDESRGVVVKAFVVLRPGVipgPVLAR 400
|
330 340 350
....*....|....*....|....*....|....*....
gi 572879274 555 EIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 593
Cdd:cd05958 401 ELQDHAKAHIAPYKYPRAIEFVTELPRTATGKLQRFALR 439
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
243-587 |
3.61e-46 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 175.50 E-value: 3.61e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 243 DPINIQFTSGTTGSPKGATLSHYNIVnnSNIlgerlklhektpEQLRMILPN----------PLYHCLGSVAGTMMCLMY 312
Cdd:PRK08633 783 DTATIIFSSGSEGEPKGVMLSHHNIL--SNI------------EQISDVFNLrnddvilsslPFFHSFGLTVTLWLPLLE 848
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 313 GATLIL-ASPIfNGKKALEAISRERGTFLYGTPTMF-----VDILNQPDFSSYDIstmcggVIAGSPA-PPELIRAIINK 385
Cdd:PRK08633 849 GIKVVYhPDPT-DALGIAKLVAKHRATILLGTPTFLrlylrNKKLHPLMFASLRL------VVAGAEKlKPEVADAFEEK 921
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 386 INmKDLVVAYGTTENSPVTFAHFP----EDTVEQ---KAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLG 458
Cdd:PRK08633 922 FG-IRILEGYGATETSPVASVNLPdvlaADFKRQtgsKEGSVGMPLPGVAVRIVDPETFEELPPGEDGLILIGGPQVMKG 1000
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 459 YWGEPQKTEEAV---DQDKWYWTGDVATMNEQGFCKIVGR----SKdmIirGGENIYPAELEDFFHTHPKVQEVQ--VVG 529
Cdd:PRK08633 1001 YLGDPEKTAEVIkdiDGIGWYVTGDKGHLDEDGFLTITDRysrfAK--I--GGEMVPLGAVEEELAKALGGEEVVfaVTA 1076
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 572879274 530 VKDDRMGEEICACIRLKDGEETTVEEIKAfcKGKISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:PRK08633 1077 VPDEKKGEKLVVLHTCGAEDVEELKRAIK--ESGLPNLWKPSRYFKVEALPLLGSGKL 1132
|
|
| PRK13382 |
PRK13382 |
bile acid CoA ligase; |
73-594 |
4.88e-46 |
|
bile acid CoA ligase;
Pssm-ID: 172019 [Multi-domain] Cd Length: 537 Bit Score: 170.32 E-value: 4.88e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 73 TVGqcLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLA--------- 143
Cdd:PRK13382 46 TSG--FAIAAQRCPDRPGLI--DELGTLTWRELDERSDALAAALQALPIGEPRVVGIMCRNHRGFVEALLAanrigadil 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 144 ----TAQAMELEYVLKKVGCKALVFPKQFktqqyynvlkqiCPEVENA---QPGALKSQRLPDLTTVISVDApLPGTLLL 216
Cdd:PRK13382 122 llntSFAGPALAEVVTREGVDTVIYDEEF------------SATVDRAladCPQATRIVAWTDEDHDLTVEV-LIAAHAG 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 217 DEVVAAGSTRQhldqlqynqqflschdpiNIQFTSGTTGSPKGATLSHY-NIVNNSNILgERLKLHEKTPeqlrMILPNP 295
Cdd:PRK13382 189 QRPEPTGRKGR------------------VILLTSGTTGTPKGARRSGPgGIGTLKAIL-DRTPWRAEEP----TVIVAP 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 296 LYHCLG----SVAGTMMCLMygatliLASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPD--FSSYDISTMCGGVI 369
Cdd:PRK13382 246 MFHAWGfsqlVLAASLACTI------VTRRRFDPEATLDLIDRHRATGLAVVPVMFDRIMDLPAevRNRYSGRSLRFAAA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 370 AGSPAPPELIRAIINKINmkDLVVA-YGTTENSPVTFAHfPEDtVEQKAESVGRIMPHTEARIMNMEAGTLAKLNTpGEL 448
Cdd:PRK13382 320 SGSRMRPDVVIAFMDQFG--DVIYNnYNATEAGMIATAT-PAD-LRAAPDTAGRPAEGTEIRILDQDFREVPTGEV-GTI 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 449 CIRGYCVMLGYwgEPQKTEEAvdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVV 528
Cdd:PRK13382 395 FVRNDTQFDGY--TSGSTKDF--HDGFMASGDVGYLDENGRLFVVGRDDEMIVSGGENVYPIEVEKTLATHPDVAEAAVI 470
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 572879274 529 GVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 594
Cdd:PRK13382 471 GVDDEQYGQRLAAFVVLKPGASATPETLKQHVRDNLANYKVPRDIVVLDELPRGATGKILRRELQA 536
|
|
| MACS_like_4 |
cd05969 |
Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most ... |
100-593 |
5.74e-46 |
|
Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); This family is most similar to acetyl-CoA synthetase. Acetyl-CoA synthetase (ACS) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is only present in bacteria.
Pssm-ID: 341273 [Multi-domain] Cd Length: 442 Bit Score: 168.06 E-value: 5.74e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 100 LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAqameleyvlkKVGCkalvfpkqfktqqyynvlkQ 179
Cdd:cd05969 1 YTFAQLKVLSARFANVLKSLGVGKGDRVFVLSPRSPELYFSMLGIG----------KIGA-------------------V 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 180 ICPEVENAQPGALKSQrlpdlttvisvdaplpgtLLLDEVVAAGSTRQHLDQLQYNqqflschDPINIQFTSGTTGSPKG 259
Cdd:cd05969 52 ICPLFSAFGPEAIRDR------------------LENSEAKVLITTEELYERTDPE-------DPTLLHYTSGTTGTPKG 106
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 260 ATLSHYNIVNNSNILGERLKLHektpeqlrmilPNPLYHCL-------GSVAGTMMCLMYGATLILASPIFNGKKALEAI 332
Cdd:cd05969 107 VLHVHDAMIFYYFTGKYVLDLH-----------PDDIYWCTadpgwvtGTVYGIWAPWLNGVTNVVYEGRFDAESWYGII 175
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 333 SRERGTFLYGTPTMFVDILNQPDF--SSYDISTMCGGVIAGSPAPPELIRAIINKINMKdLVVAYGTTENSPVTFAHFPE 410
Cdd:cd05969 176 ERVKVTVWYTAPTAIRMLMKEGDElaRKYDLSSLRFIHSVGEPLNPEAIRWGMEVFGVP-IHDTWWQTETGSIMIANYPC 254
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 411 DTVeqKAESVGRIMPHTEARIMNMEAGTLAKlNTPGELCIR-GYCVML-GYWGEPQKTEEAVdQDKWYWTGDVATMNEQG 488
Cdd:cd05969 255 MPI--KPGSMGKPLPGVKAAVVDENGNELPP-GTKGILALKpGWPSMFrGIWNDEERYKNSF-IDGWYLTGDLAYRDEDG 330
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 489 FCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVE---EIKAFCKGKIS 565
Cdd:cd05969 331 YFWFVGRADDIIKTSGHRVGPFEVESALMEHPAVAEAGVIGKPDPLRGEIIKAFISLKEGFEPSDElkeEIINFVRQKLG 410
|
490 500
....*....|....*....|....*...
gi 572879274 566 HFKIPKYIVFVTNYPLTISGKIQKFKLR 593
Cdd:cd05969 411 AHVAPREIEFVDNLPKTRSGKIMRRVLK 438
|
|
| PRK06018 |
PRK06018 |
putative acyl-CoA synthetase; Provisional |
98-595 |
7.22e-46 |
|
putative acyl-CoA synthetase; Provisional
Pssm-ID: 235673 [Multi-domain] Cd Length: 542 Bit Score: 169.93 E-value: 7.22e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 98 VRLTFAQLKEEVDKAASGLLSIGLCKGDRLGmwgpnSYAWvlmqlATAQAMELEYVLKKVG--CKAL---VFPKQ----- 167
Cdd:PRK06018 38 VRTTYAQIHDRALKVSQALDRDGIKLGDRVA-----TIAW-----NTWRHLEAWYGIMGIGaiCHTVnprLFPEQiawii 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 168 --------FKTQQYYNVLKQICPevenaqpgalksqRLPDLTT-VISVDAP------LPGTLLLDEVVAAGSTRQHLDQL 232
Cdd:PRK06018 108 nhaedrvvITDLTFVPILEKIAD-------------KLPSVERyVVLTDAAhmpqttLKNAVAYEEWIAEADGDFAWKTF 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 233 QYNQQFLSChdpiniqFTSGTTGSPKGATLSHYN------IVNNSNILGERLKlhektpeqlRMILPN-PLYHClGSVAG 305
Cdd:PRK06018 175 DENTAAGMC-------YTSGTTGDPKGVLYSHRSnvlhalMANNGDALGTSAA---------DTMLPVvPLFHA-NSWGI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 306 TMMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINk 385
Cdd:PRK06018 238 AFSAPSMGTKLVMPGAKLDGASVYELLDTEKVTFTAGVPTVWLMLLQYMEKEGLKLPHLKMVVCGGSAMPRSMIKAFED- 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 386 inMKDLVV-AYGTTENSPV--------TFAHFPED---TVEQKAesvGRIMPHTEARIMNMEAGTLAKL-NTPGELCIRG 452
Cdd:PRK06018 317 --MGVEVRhAWGMTEMSPLgtlaalkpPFSKLPGDarlDVLQKQ---GYPPFGVEMKITDDAGKELPWDgKTFGRLKVRG 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 453 YCVMLGYWGEPQkteEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKD 532
Cdd:PRK06018 392 PAVAAAYYRVDG---EILDDDGFFDTGDVATIDAYGYMRITDRSKDVIKSGGEWISSIDLENLAVGHPKVAEAAVIGVYH 468
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 572879274 533 DRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:PRK06018 469 PKWDERPLLIVQLKPGETATREEILKYMDGKIAKWWMPDDVAFVDAIPHTATGKILKTALREQ 531
|
|
| MACS_AAE_MA_like |
cd05970 |
Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation ... |
82-595 |
9.96e-46 |
|
Medium-chain acyl-CoA synthetase (MACS) of AAE_MA like; MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This family of MACS enzymes is found in archaea and bacteria. It is represented by the acyl-adenylating enzyme from Methanosarcina acetivorans (AAE_MA). AAE_MA is most active with propionate, butyrate, and the branched analogs: 2-methyl-propionate, butyrate, and pentanoate. The specific activity is weaker for smaller or larger acids.
Pssm-ID: 341274 [Multi-domain] Cd Length: 537 Bit Score: 169.60 E-value: 9.96e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 82 AQRVPEREALVVLH---EDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYA-WVLMQL----------ATAQ- 146
Cdd:cd05970 27 AKEYPDKLALVWCDdagEERIFTFAELADYSDKTANFFKAMGIGKGDTVMLTLKRRYEfWYSLLAlhklgaiaipATHQl 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 147 -AMELEYVLKKVGCKALVFPKQFKTQQyynvlkqicpEVENAQPgalksqRLPDLTTVISVDAPLP-GTLLLDEVVAAGS 224
Cdd:cd05970 107 tAKDIVYRIESADIKMIVAIAEDNIPE----------EIEKAAP------ECPSKPKLVWVGDPVPeGWIDFRKLIKNAS 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 225 ---TRQHLDQLQYNQqflschDPINIQFTSGTTGSPKgaTLSHynivNNSNILGerlklHEKTPEQLRMILPNPLYHclg 301
Cdd:cd05970 171 pdfERPTANSYPCGE------DILLVYFSSGTTGMPK--MVEH----DFTYPLG-----HIVTAKYWQNVREGGLHL--- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 302 SVAGT-----MMCLMYG------ATLILASPIFNGKKALEAISRERGTFLYGTPTMFvDILNQPDFSSYDISTMCGGVIA 370
Cdd:cd05970 231 TVADTgwgkaVWGKIYGqwiagaAVFVYDYDKFDPKALLEKLSKYGVTTFCAPPTIY-RFLIREDLSRYDLSSLRYCTTA 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 371 GSPAPPELIRAIINKINMKdLVVAYGTTENSpVTFAHFPedTVEQKAESVGRIMPHTEARIMNMEaGTLAKLNTPGELCI 450
Cdd:cd05970 310 GEALNPEVFNTFKEKTGIK-LMEGFGQTETT-LTIATFP--WMEPKPGSMGKPAPGYEIDLIDRE-GRSCEAGEEGEIVI 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 451 R---GYCVML--GYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEV 525
Cdd:cd05970 385 RtskGKPVGLfgGYYKDAEKTAEVW-HDGYYHTGDAAWMDEDGYLWFVGRTDDLIKSSGYRIGPFEVESALIQHPAVLEC 463
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 572879274 526 QVVGVKDDRMGEEICACIRLKDG---EETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:cd05970 464 AVTGVPDPIRGQVVKATIVLAKGyepSEELKKELQDHVKKVTAPYKYPRIVEFVDELPKTISGKIRRVEIRER 536
|
|
| PLN02479 |
PLN02479 |
acetate-CoA ligase |
78-593 |
3.29e-44 |
|
acetate-CoA ligase
Pssm-ID: 178097 [Multi-domain] Cd Length: 567 Bit Score: 165.79 E-value: 3.29e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAW------VLMQLATAQAMELE 151
Cdd:PLN02479 26 LERAAVVHPTRKSVV--HGSVRYTWAQTYQRCRRLASALAKRSIGPGSTVAVIAPNIPAMyeahfgVPMAGAVVNCVNIR 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 152 -------YVLKKVGCKALVFpkqfkTQQYYNVLKQICPEVENAQPGALKsqrlPDLTTVISVDAPLPGTLllDEVVAAGS 224
Cdd:PLN02479 104 lnaptiaFLLEHSKSEVVMV-----DQEFFTLAEEALKILAEKKKSSFK----PPLLIVIGDPTCDPKSL--QYALGKGA 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 225 trqhldqLQYnQQFLSCHDP-------------INIQFTSGTTGSPKGATLSHYNI----VNNSNILGerlklhekTPEQ 287
Cdd:PLN02479 173 -------IEY-EKFLETGDPefawkppadewqsIALGYTSGTTASPKGVVLHHRGAylmaLSNALIWG--------MNEG 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 288 LRMILPNPLYHC--------LGSVAGTMMCLMYgatlILASPIFNgkkaleAISRERGTFLYGTPTMFVDILNQPDFSSY 359
Cdd:PLN02479 237 AVYLWTLPMFHCngwcftwtLAALCGTNICLRQ----VTAKAIYS------AIANYGVTHFCAAPVVLNTIVNAPKSETI 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 360 -DISTMCGGVIAGSPAPPELIRAIinkiNMKDLVVA--YGTTEN-SPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNME 435
Cdd:PLN02479 307 lPLPRVVHVMTAGAAPPPSVLFAM----SEKGFRVThtYGLSETyGPSTVCAWKPEWDSLPPEEQARLNARQGVRYIGLE 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 436 ----------AGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGE 505
Cdd:PLN02479 383 gldvvdtktmKPVPADGKTMGEIVMRGNMVMKGYLKNPKANEEAF-ANGWFHSGDLGVKHPDGYIEIKDRSKDIIISGGE 461
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 506 NIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDG-----EETTVEEIKAFCKGKISHFKIPKYIVFvTNYP 580
Cdd:PLN02479 462 NISSLEVENVVYTHPAVLEASVVARPDERWGESPCAFVTLKPGvdksdEAALAEDIMKFCRERLPAYWVPKSVVF-GPLP 540
|
570
....*....|...
gi 572879274 581 LTISGKIQKFKLR 593
Cdd:PLN02479 541 KTATGKIQKHVLR 553
|
|
| PLN03102 |
PLN03102 |
acyl-activating enzyme; Provisional |
78-594 |
8.97e-44 |
|
acyl-activating enzyme; Provisional
Pssm-ID: 215576 [Multi-domain] Cd Length: 579 Bit Score: 164.81 E-value: 8.97e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATA------------ 145
Cdd:PLN03102 20 LKRASECYPNRTSII--YGKTRFTWPQTYDRCCRLAASLISLNITKNDVVSVLAPNTPAMYEMHFAVPmagavlnpintr 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 146 -QAMELEYVLKKVGCKALVFPKQFKTQqYYNVLKQICPEVENAQPGALKSQRLPDLTTVISVDAPLPGTLLLDEVVAAGS 224
Cdd:PLN03102 98 lDATSIAAILRHAKPKILFVDRSFEPL-AREVLHLLSSEDSNLNLPVIFIHEIDFPKRPSSEELDYECLIQRGEPTPSLV 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 225 TRQHLDQLQynqqflscHDPINIQFTSGTTGSPKGATLSHYN--IVNNSNILGERLKLhekTPEQLRMIlpnPLYHCLG- 301
Cdd:PLN03102 177 ARMFRIQDE--------HDPISLNYTSGTTADPKGVVISHRGayLSTLSAIIGWEMGT---CPVYLWTL---PMFHCNGw 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 302 ----SVA---GTMMCLMYgatlILASPIFNGkkaleaISRERGTFLYGTPTMFVDILNQpdfSSYDISTMCGGV---IAG 371
Cdd:PLN03102 243 tftwGTAargGTSVCMRH----VTAPEIYKN------IEMHNVTHMCCVPTVFNILLKG---NSLDLSPRSGPVhvlTGG 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 372 SPAPPELIRAIiNKINMKdLVVAYGTTENS-PVTFAHF-------PEDT-VEQKAESVGRIMPHTEARIMNMEagTLAKL 442
Cdd:PLN03102 310 SPPPAALVKKV-QRLGFQ-VMHAYGLTEATgPVLFCEWqdewnrlPENQqMELKARQGVSILGLADVDVKNKE--TQESV 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 443 ----NTPGELCIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHT 518
Cdd:PLN03102 386 prdgKTMGEIVIKGSSIMKGYLKNPKATSEAF-KHGWLNTGDVGVIHPDGHVEIKDRSKDIIISGGENISSVEVENVLYK 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 519 HPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAF----------CKGKISHFKIPKYIVFVTNYPLTISGKIQ 588
Cdd:PLN03102 465 YPKVLETAVVAMPHPTWGETPCAFVVLEKGETTKEDRVDKLvtrerdlieyCRENLPHFMCPRKVVFLQELPKNGNGKIL 544
|
....*.
gi 572879274 589 KFKLRE 594
Cdd:PLN03102 545 KPKLRD 550
|
|
| DltA |
cd05945 |
D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes ... |
82-592 |
1.10e-43 |
|
D-alanine:D-alanyl carrier protein ligase (DltA) and similar proteins; This family includes D-alanyl carrier protein ligase DltA and aliphatic beta-amino acid adenylation enzymes IdnL1 and CmiS6. DltA incorporates D-ala in techoic acids in gram-positive bacteria via a two-step process, starting with adenylation of D-alanine that transfers D-alanine to the D-alanyl carrier protein. IdnL1, a short-chain aliphatic beta-amino acid adenylation enzyme, recognizes 3-aminobutanoic acid, and is involved in the synthesis of the macrolactam antibiotic incednine. CmiS6 is a medium-chain beta-amino acid adenylation enzyme that recognizes 3-aminononanoic acid, and is involved in the synthesis of cremimycin, also a macrolactam antibiotic. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341267 [Multi-domain] Cd Length: 449 Bit Score: 162.03 E-value: 1.10e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 82 AQRVPEReaLVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPnsyawvlmqlataqaMELEYVLKKVGCka 161
Cdd:cd05945 1 AAANPDR--PAVVEGGRTLTYRELKERADALAAALASLGLDAGDPVVVYGH---------------KSPDAIAAFLAA-- 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 162 lvfpkqfktqqyynvLKQICPEV--ENAQPgalkSQRLpdlTTVISVDAPlpgtlllDEVVAAGstrqhldqlqynqqfl 239
Cdd:cd05945 62 ---------------LKAGHAYVplDASSP----AERI---REILDAAKP-------ALLIADG---------------- 96
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 240 scHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhektPEQLRmILPNPLYHCLGSVAGTMMCLMYGATLILA 319
Cdd:cd05945 97 --DDNAYIIFTSGSTGRPKGVQISHDNLVSFTNWMLSDFPL----GPGDV-FLNQAPFSFDLSVMDLYPALASGATLVPV 169
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 320 SP--IFNGKKALEAISRERGTFLYGTPTmFVDILNQ-PDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYG 396
Cdd:cd05945 170 PRdaTADPKQLFRFLAEHGITVWVSTPS-FAAMCLLsPTFTPESLPSLRHFLFCGEVLPHKTARALQQRFPDARIYNTYG 248
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 397 TTE-NSPVTFAHFPEDTVEQkAESV--GRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQD 473
Cdd:cd05945 249 PTEaTVAVTYIEVTPEVLDG-YDRLpiGYAKPGAKLVILD-EDGRPVPPGEKGELVISGPSVSKGYLNNPEKTAAAFFPD 326
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 474 K---WYWTGDVATMNEQGFCKIVGRSKDMI-IRGgeniYPAELED---FFHTHPKVQEVQVVGVKDDRMGEEICACIRLK 546
Cdd:cd05945 327 EgqrAYRTGDLVRLEADGLLFYRGRLDFQVkLNG----YRIELEEieaALRQVPGVKEAVVVPKYKGEKVTELIAFVVPK 402
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 572879274 547 DGEE---TTveEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKL 592
Cdd:cd05945 403 PGAEaglTK--AIKAELAERLPPYMIPRRFVYLDELPLNANGKIDRKAL 449
|
|
| Firefly_Luc |
cd17642 |
insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect ... |
85-594 |
1.36e-43 |
|
insect luciferase, similar to plant 4-coumarate: CoA ligases; This family contains insect firefly luciferases that share significant sequence similarity to plant 4-coumarate:coenzyme A ligases, despite their functional diversity. Luciferase catalyzes the production of light in the presence of MgATP, molecular oxygen, and luciferin. In the first step, luciferin is activated by acylation of its carboxylate group with ATP, resulting in an enzyme-bound luciferyl adenylate. In the second step, luciferyl adenylate reacts with molecular oxygen, producing an enzyme-bound excited state product (Luc=O*) and releasing AMP. This excited-state product then decays to the ground state (Luc=O), emitting a quantum of visible light.
Pssm-ID: 341297 [Multi-domain] Cd Length: 532 Bit Score: 163.47 E-value: 1.36e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 85 VPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSyawvlMQLATAqameleyVLKKVGCKALVF 164
Cdd:cd17642 30 VPGTIAFTDAHTGVNYSYAEYLEMSVRLAEALKKYGLKQNDRIAVCSENS-----LQFFLP-------VIAGLFIGVGVA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 165 PkqfkTQQYYNvLKQICPEVENAQPGALKSQRLpDLTTVISVDAPLPgtllLDEVVAAGSTRQHLDQLQYNQQFLSCHDP 244
Cdd:cd17642 98 P----TNDIYN-ERELDHSLNISKPTIVFCSKK-GLQKVLNVQKKLK----IIKTIIILDSKEDYKGYQCLYTFITQNLP 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 245 IN-------------------IQFTSGTTGSPKGATLSHYNIVnnsnilgERLKlHEKTPEQLRMILPN-------PLYH 298
Cdd:cd17642 168 PGfneydfkppsfdrdeqvalIMNSSGSTGLPKGVQLTHKNIV-------ARFS-HARDPIFGNQIIPDtailtviPFHH 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 299 CLG--SVAGTMMClmyGATLILAsPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPP 376
Cdd:cd17642 240 GFGmfTTLGYLIC---GFRVVLM-YKFEEELFLRSLQDYKVQSALLVPTLFAFFAKSTLVDKYDLSNLHEIASGGAPLSK 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 377 ELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTveqKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVM 456
Cdd:cd17642 316 EVGEAVAKRFKLPGIRQGYGLTETTSAILITPEGDD---KPGAVGKVVPFFYAKVVDLDTGKTLGPNERGELCVKGPMIM 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 457 LGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMG 536
Cdd:cd17642 393 KGYVNNPEATKALIDKDGWLHSGDIAYYDEDGHFFIVDRLKSLIKYKGYQVPPAELESILLQHPKIFDAGVAGIPDEDAG 472
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 572879274 537 EEICACIRLKDGEETTVEEIKAFCKGKISHFK-IPKYIVFVTNYPLTISGKIQKFKLRE 594
Cdd:cd17642 473 ELPAAVVVLEAGKTMTEKEVMDYVASQVSTAKrLRGGVKFVDEVPKGLTGKIDRRKIRE 531
|
|
| A_NRPS_Srf_like |
cd12117 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis ... |
79-592 |
1.93e-43 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the adenylation domain of the Bacillus subtilis termination module (Surfactin domain, SrfA-C) which recognizes a specific amino acid building block, which is then activated and transferred to the terminal thiol of the 4'-phosphopantetheine (Ppan) arm of the downstream peptidyl carrier protein (PCP) domain.
Pssm-ID: 341282 [Multi-domain] Cd Length: 483 Bit Score: 161.98 E-value: 1.93e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 79 ETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQA----------- 147
Cdd:cd12117 4 EEQAARTPDAVAVV--YGDRSLTYAELNERANRLARRLRAAGVGPGDVVGVLAERSPELVVALLAVLKAgaayvpldpel 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 148 --MELEYVLKKVGCKALVfpkqfkTQqyynvlkqicpevenaqpGALKSQRLPDLTTVISVDAPLPGTLLLDEVVAAGst 225
Cdd:cd12117 82 paERLAFMLADAGAKVLL------TD------------------RSLAGRAGGLEVAVVIDEALDAGPAGNPAVPVSP-- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 226 rqhlDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYNI---VNNSNILGERlklhektpEQLRMILPNPlyhcLGS 302
Cdd:cd12117 136 ----DDLAY------------VMYTSGSTGRPKGVAVTHRGVvrlVKNTNYVTLG--------PDDRVLQTSP----LAF 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 303 VAGTM---MCLMYGATLILASP--IFNGKKALEAISRERGTFLYGTPTMF---VDIlnQPDfssydistMCGGV----IA 370
Cdd:cd12117 188 DASTFeiwGALLNGARLVLAPKgtLLDPDALGALIAEEGVTVLWLTAALFnqlADE--DPE--------CFAGLrellTG 257
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 371 GSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVEQkAESV--GRIMPHTEARIMNmEAGTLAKLNTPGEL 448
Cdd:cd12117 258 GEVVSPPHVRRVLAACPGLRLVNGYGPTENTTFTTSHVVTELDEV-AGSIpiGRPIANTRVYVLD-EDGRPVPPGVPGEL 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 449 CIRGYCVMLGYWGEPQKTEEAVDQD------KWYWTGDVATMNEQGFCKIVGRSKDMI-IRgGENIYPAELEDFFHTHPK 521
Cdd:cd12117 336 YVGGDGLALGYLNRPALTAERFVADpfgpgeRLYRTGDLARWLPDGRLEFLGRIDDQVkIR-GFRIELGEIEAALRAHPG 414
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 572879274 522 VQEVqVVGVKDDRMGE-EICACIRLKdgEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKL 592
Cdd:cd12117 415 VREA-VVVVREDAGGDkRLVAYVVAE--GALDAAELRAFLRERLPAYMVPAAFVVLDELPLTANGKVDRRAL 483
|
|
| ttLC_FACS_like |
cd05915 |
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes ... |
87-594 |
1.70e-41 |
|
Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; This family includes fatty acyl-CoA synthetases that can activate medium-chain to long-chain fatty acids. They catalyze the ATP-dependent acylation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. Fatty acyl-CoA synthetases are responsible for fatty acid degradation as well as physiological regulation of cellular functions via the production of fatty acyl-CoA esters. The fatty acyl-CoA synthetase from Thermus thermophiles in this family has been shown to catalyze the long-chain fatty acid, myristoyl acid, while another member in this family, the AlkK protein identified in Pseudomonas oleovorans, targets medium chain fatty acids. This family also includes an uncharacterized subgroup of FACS.
Pssm-ID: 213283 [Multi-domain] Cd Length: 509 Bit Score: 157.21 E-value: 1.70e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 87 EREALVV---LHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVlmqlataqamELEYVLKKVGCKALV 163
Cdd:cd05915 9 GRKEVVSrlhTGEVHRTTYAEVYQRARRLMGGLRALGVGVGDRVATLGFNHFRHL----------EAYFAVPGMGAVLHT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 164 FPKQFKTQQYYNVLKQICPEV--ENAQPGALKSQRLPDLTTVisvdaplpgtllldevvaagsTRQHLDQLQYNQ--QFL 239
Cdd:cd05915 79 ANPRLSPKEIAYILNHAEDKVllFDPNLLPLVEAIRGELKTV---------------------QHFVVMDEKAPEgyLAY 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 240 SCH-------------DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEK-TPEQLRMIlpnPLYHCLGSVAg 305
Cdd:cd05915 138 EEAlgeeadpvrvperAACGMAYTTGTTGLPKGVVYSHRALVLHSLAASLVDGTALSeKDVVLPVV---PMFHVNAWCL- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 306 TMMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDF--SSYDISTMcggVIAGSPAPPELIRAiI 383
Cdd:cd05915 214 PYAATLVGAKQVLPGPRLDPASLVELFDGEGVTFTAGVPTVWLALADYLEStgHRLKTLRR---LVVGGSAAPRSLIA-R 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 384 NKINMKDLVVAYGTTENSPVTFA--------HFPE---------DTVEQKAESVGRIMPHTearimnMEAGTLAKlnTPG 446
Cdd:cd05915 290 FERMGVEVRQGYGLTETSPVVVQnfvkshleSLSEeekltlkakTGLPIPLVRLRVADEEG------RPVPKDGK--ALG 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 447 ELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQ 526
Cdd:cd05915 362 EVQLKGPWITGGYYGNEEATRSALTPDGFFRTGDIAVWDEEGYVEIKDRLKDLIKSGGEWISSVDLENALMGHPKVKEAA 441
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 572879274 527 VVGVKDDRMGEEICACIRLKDGEETTvEEIKAFCKGKISHFK-IPKYIVFVTNYPLTISGKIQKFKLRE 594
Cdd:cd05915 442 VVAIPHPKWQERPLAVVVPRGEKPTP-EELNEHLLKAGFAKWqLPDAYVFAEEIPRTSAGKFLKRALRE 509
|
|
| PRK05852 |
PRK05852 |
fatty acid--CoA ligase family protein; |
78-595 |
1.46e-40 |
|
fatty acid--CoA ligase family protein;
Pssm-ID: 235625 [Multi-domain] Cd Length: 534 Bit Score: 155.04 E-value: 1.46e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAMELEYVLKKv 157
Cdd:PRK05852 22 VEVAATRLPEAPALVVTADRIAISYRDLARLVDDLAGQLTRSGLLPGDRVALRMGSNAEFVVALLAASRADLVVVPLDP- 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 158 gckALVFPKQFKTQQYYN---VLKQICPEVENAQPGAlksQRLPDLTTVISVDAPLPGTLLLDEVVAAGST-RQHLDQ-L 232
Cdd:PRK05852 101 ---ALPIAEQRVRSQAAGarvVLIDADGPHDRAEPTT---RWWPLTVNVGGDSGPSGGTLSVHLDAATEPTpATSTPEgL 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 233 QynqqflscHDPINIQFTSGTTGSPKGATLSHYNIVNN--SNILGERLKLHEKTpeqlrmILPNPLYHCLGSVAGTMMCL 310
Cdd:PRK05852 175 R--------PDDAMIMFTGGTTGLPKMVPWTHANIASSvrAIITGYRLSPRDAT------VAVMPLYHGHGLIAALLATL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 311 MYGATLIL-ASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAP--PELIRAIINKIN 387
Cdd:PRK05852 241 ASGGAVLLpARGRFSAHTFWDDIKAVGATWYTAVPTIHQILLERAATEPSGRKPAALRFIRSCSAPltAETAQALQTEFA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 388 MKdLVVAYGTTE--NSPVTFAHFPEDTVEQKAESVGRIMPHTEA--RIMNMEAGTLAKlNTPGELCIRGYCVMLGYWGEP 463
Cdd:PRK05852 321 AP-VVCAFGMTEatHQVTTTQIEGIGQTENPVVSTGLVGRSTGAqiRIVGSDGLPLPA-GAVGEVWLRGTTVVRGYLGDP 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 464 QKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACI 543
Cdd:PRK05852 399 TITAANF-TDGWLRTGDLGSLSAAGDLSIRGRIKELINRGGEKISPERVEGVLASHPNVMEAAVFGVPDQLYGEAVAAVI 477
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 572879274 544 RLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:PRK05852 478 VPRESAPPTAEELVQFCRERLAAFEIPASFQEASGLPHTAKGSLDRRAVAEQ 529
|
|
| LC_FACL_like |
cd05914 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are ... |
95-590 |
1.70e-40 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341240 [Multi-domain] Cd Length: 463 Bit Score: 153.37 E-value: 1.70e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 95 HEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATaqameleyvlkkVGCKALVFP--KQFKTQQ 172
Cdd:cd05914 3 YGGEPLTYKDLADNIAKFALLLKINGVGTGDRVALMGENRPEWGIAFFAI------------WTYGAIAVPilAEFTADE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 173 YYNVLkqicpevENAQPGALksqrlpdlttvisvdaplpgtllldevvaagstrqhldqlqynqqFLSCHDPIN-IQFTS 251
Cdd:cd05914 71 VHHIL-------NHSEAKAI---------------------------------------------FVSDEDDVAlINYTS 98
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 252 GTTGSPKGATLSHYNIVNNSNiLGERLKLHEKTPEQLRMIlpnPLYHCLGSVAGTMMCLMYGATLILASPIFNGKkaLEA 331
Cdd:cd05914 99 GTTGNSKGVMLTYRNIVSNVD-GVKEVVLLGKGDKILSIL---PLHHIYPLTFTLLLPLLNGAHVVFLDKIPSAK--IIA 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 332 ISRERGTFLYGTPTMFV-------DILNQPDFS-----------SYDISTMC--------GG-----VIAGSPAPPElIR 380
Cdd:cd05914 173 LAFAQVTPTLGVPVPLViekifkmDIIPKLTLKkfkfklakkinNRKIRKLAfkkvheafGGnikefVIGGAKINPD-VE 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 381 AIINKINMKdLVVAYGTTENSPVTFAHFPEDTveqKAESVGRIMPHTEARIMNMEAGTLAklntpGELCIRGYCVMLGYW 460
Cdd:cd05914 252 EFLRTIGFP-YTIGYGMTETAPIISYSPPNRI---RLGSAGKVIDGVEVRIDSPDPATGE-----GEIIVRGPNVMKGYY 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 461 GEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRG-GENIYPAELEDFFHTHPKVQEVQVVgVKDDRM---- 535
Cdd:cd05914 323 KNPEATAEAFDKDGWFHTGDLGKIDAEGYLYIRGRKKEMIVLSsGKNIYPEEIEAKINNMPFVLESLVV-VQEKKLvala 401
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 572879274 536 -----GEEICAcIRLKDGEETTVEEIKAFCKGKISHF-KIPKYIVFVTNYPLTISGKIQKF 590
Cdd:cd05914 402 yidpdFLDVKA-LKQRNIIDAIKWEVRDKVNQKVPNYkKISKVKIVKEEFEKTPKGKIKRF 461
|
|
| PRK04319 |
PRK04319 |
acetyl-CoA synthetase; Provisional |
95-602 |
3.71e-40 |
|
acetyl-CoA synthetase; Provisional
Pssm-ID: 235279 [Multi-domain] Cd Length: 570 Bit Score: 154.28 E-value: 3.71e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 95 HEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNS---YAWVLMQLataqameleyvlkKVGckALVFPkqfktq 171
Cdd:PRK04319 69 SRKEKYTYKELKELSNKFANVLKELGVEKGDRVFIFMPRIpelYFALLGAL-------------KNG--AIVGP------ 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 172 qyynVLKQICPE-----VENAQPGAL----------KSQRLPDLTTVISVDAP---LPGTLLLDEVVAAGSTrqhldqlQ 233
Cdd:PRK04319 128 ----LFEAFMEEavrdrLEDSEAKVLittpallerkPADDLPSLKHVLLVGEDveeGPGTLDFNALMEQASD-------E 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 234 YNQQFLSCHDPINIQFTSGTTGSPKG------ATLSHYnivnnsnILGER-LKLHektpeqlrmilPNPLYHCL---GSV 303
Cdd:PRK04319 197 FDIEWTDREDGAILHYTSGSTGKPKGvlhvhnAMLQHY-------QTGKYvLDLH-----------EDDVYWCTadpGWV 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 304 AGT----MMCLMYGATLILASPIFNGKKALEAISRERGTFLYGTPTMF-------VDILNQPDFSS--YDISTmcggvia 370
Cdd:PRK04319 259 TGTsygiFAPWLNGATNVIDGGRFSPERWYRILEDYKVTVWYTAPTAIrmlmgagDDLVKKYDLSSlrHILSV------- 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 371 GSPAPPELIRAiinkiNMKdlvvAYG--------TTENSPVTFAHFPedTVEQKAESVGRIMPHTEARIMNMEAGTLAKl 442
Cdd:PRK04319 332 GEPLNPEVVRW-----GMK----VFGlpihdnwwMTETGGIMIANYP--AMDIKPGSMGKPLPGIEAAIVDDQGNELPP- 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 443 NTPGELCIR-GYCVML-GYWGEPQKTEEAVDQDkWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHP 520
Cdd:PRK04319 400 NRMGNLAIKkGWPSMMrGIWNNPEKYESYFAGD-WYVSGDSAYMDEDGYFWFQGRVDDVIKTSGERVGPFEVESKLMEHP 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 521 KVQEVQVVGVKDDRMGEEICACIRLKDGEETTVE---EIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQK--FKLREq 595
Cdd:PRK04319 479 AVAEAGVIGKPDPVRGEIIKAFVALRPGYEPSEElkeEIRGFVKKGLGAHAAPREIEFKDKLPKTRSGKIMRrvLKAWE- 557
|
....*..
gi 572879274 596 merhLNL 602
Cdd:PRK04319 558 ----LGL 560
|
|
| LC_FACS_like |
cd17640 |
Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA ... |
98-536 |
4.62e-40 |
|
Long-chain fatty acid CoA synthetase; This family includes long-chain fatty acid (C12-C20) CoA synthetases, including an Arabidopsis gene At4g14070 that plays a role in activation and elongation of exogenous fatty acids. FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Eukaryotes generally have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341295 [Multi-domain] Cd Length: 468 Bit Score: 152.51 E-value: 4.62e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 98 VRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLAT-------------AQAMELEYVLKKVGCKALVf 164
Cdd:cd17640 4 KRITYKDLYQEILDFAAGLRSLGVKAGEKVALFADNSPRWLIADQGImalgavdvvrgsdSSVEELLYILNHSESVALV- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 165 pkqfktqqyynvlkqicpeVENAQPgalksqrlpDLTTVIsvdaplpgtllldevvaagstrqhldqlqynqqflschdp 244
Cdd:cd17640 83 -------------------VENDSD---------DLATII---------------------------------------- 94
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 245 iniqFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHC--------LGSVAGTMMC------- 309
Cdd:cd17640 95 ----YTSGTTGNPKGVMLTHANLLHQIRSLSDIVPPQPGD----RFLSILPIWHSyersaeyfIFACGCSQAYtsirtlk 166
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 310 ---LMYGATLILASP-----IFNG-KKALEAISRER----GTFLYGTPTMFVdilnqpdfssydistmcggvIAGSPAPP 376
Cdd:cd17640 167 ddlKRVKPHYIVSVPrlwesLYSGiQKQVSKSSPIKqflfLFFLSGGIFKFG--------------------ISGGGALP 226
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 377 ELIRAIINKINMKdLVVAYGTTENSPVTFAHFPEDTVeqkAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVM 456
Cdd:cd17640 227 PHVDTFFEAIGIE-VLNGYGLTETSPVVSARRLKCNV---RGSVGRPLPGTEIKIVDPEGNVVLPPGEKGIVWVRGPQVM 302
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 457 LGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMII-RGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRM 535
Cdd:cd17640 303 KGYYKNPEATSKVLDSDGWFNTGDLGWLTCGGELVLTGRAKDTIVlSNGENVEPQPIEEALMRSPFIEQIMVVGQDQKRL 382
|
.
gi 572879274 536 G 536
Cdd:cd17640 383 G 383
|
|
| PtmA |
cd17636 |
long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, ... |
243-585 |
8.79e-40 |
|
long-chain fatty acid CoA ligase (FadD); This family contains fatty acid CoA ligases, including acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II, most of which are yet to be characterized. Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341291 [Multi-domain] Cd Length: 331 Bit Score: 148.22 E-value: 8.79e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 243 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHclgsvAGTMMCLMygATLILAS-- 320
Cdd:cd17636 1 DPVLAIYTAAFSGRPNGALLSHQALLAQALVLAVLQAIDEGT----VFLNSGPLFH-----IGTLMFTL--ATFHAGGtn 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 321 ---PIFNGKKALEAISRER--GTFLYGtPTMF----VDILNQPDFSS-YDISTMCGGVIAGSPAPPELIRAiinkinmkd 390
Cdd:cd17636 70 vfvRRVDAEEVLELIEAERctHAFLLP-PTIDqiveLNADGLYDLSSlRSSPAAPEWNDMATVDTSPWGRK--------- 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 391 lVVAYGTTENS-PVTFAHFPEDTVEqkaeSVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEA 469
Cdd:cd17636 140 -PGGYGQTEVMgLATFAALGGGAIG----GAGRPSPLVQVRILD-EDGREVPDGEVGEIVARGPTVMAGYWNRPEVNARR 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 470 VdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGE 549
Cdd:cd17636 214 T-RGGWHHTNDLGRREPDGSLSFVGPKTRMIKSGAENIYPAEVERCLRQHPAVADAAVIGVPDPRWAQSVKAIVVLKPGA 292
|
330 340 350
....*....|....*....|....*....|....*.
gi 572879274 550 ETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISG 585
Cdd:cd17636 293 SVTEAELIEHCRARIASYKKPKSVEFADALPRTAGG 328
|
|
| FACL_like_5 |
cd05924 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
241-586 |
7.13e-38 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341248 [Multi-domain] Cd Length: 364 Bit Score: 143.68 E-value: 7.13e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 241 CHDPINIQFTSGTTGSPKGATLSHYNIVNNS---------NILGERLKLHEKTP-EQLRMILPNPLYHCLGSVAGtMMCL 310
Cdd:cd05924 2 SADDLYILYTGGTTGMPKGVMWRQEDIFRMLmggadfgtgEFTPSEDAHKAAAAaAGTVMFPAPPLMHGTGSWTA-FGGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 311 MYGATLILASPIFNGKKALEAISRERGTFLygtpTMFVDILNQP------DFSSYDISTMCGGVIAGSPAPPELIRAIIN 384
Cdd:cd05924 81 LGGQTVVLPDDRFDPEEVWRTIEKHKVTSM----TIVGDAMARPlidalrDAGPYDLSSLFAISSGGALLSPEVKQGLLE 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 385 KINMKDLVVAYGTTENSPVTFAHfpedTVEQKAESVGRIMPHTEARIMNMEAGTLAK-LNTPGELCIRGYcVMLGYWGEP 463
Cdd:cd05924 157 LVPNITLVDAFGSSETGFTGSGH----SAGSGPETGPFTRANPDTVVLDDDGRVVPPgSGGVGWIARRGH-IPLGYYGDE 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 464 QKTEEA---VDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEIC 540
Cdd:cd05924 232 AKTAETfpeVDGVRYAVPGDRATVEADGTVTLLGRGSVCINTGGEKVFPEEVEEALKSHPAVYDVLVVGRPDERWGQEVV 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 572879274 541 ACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGK 586
Cdd:cd05924 312 AVVQLREGAGVDLEELREHCRTRIARYKLPKQVVFVDEIERSPAGK 357
|
|
| PRK13390 |
PRK13390 |
acyl-CoA synthetase; Provisional |
80-593 |
1.20e-37 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 139538 [Multi-domain] Cd Length: 501 Bit Score: 146.31 E-value: 1.20e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 80 TTAQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNS-YAWVLMQLA-------TA-----Q 146
Cdd:PRK13390 5 THAQIAPDRPAVIVAETGEQVSYRQLDDDSAALARVLYDAGLRTGDVVALLSDNSpEALVVLWAAlrsglyiTAinhhlT 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 147 AMELEYVLKKVGCKALVfpkqfktqqyynvlkqicpevENAQPGALKSQRLPDLTTVISVDAPLPGTLLLDEVVAAGSTR 226
Cdd:PRK13390 85 APEADYIVGDSGARVLV---------------------ASAALDGLAAKVGADLPLRLSFGGEIDGFGSFEAALAGAGPR 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 227 qhLDQLQYNQQFLschdpiniqFTSGTTGSPKG--ATLSHYNIVNNSN-ILGERLKLHEKTPEQLrMILPNPLYHclgsV 303
Cdd:PRK13390 144 --LTEQPCGAVML---------YSSGTTGFPKGiqPDLPGRDVDAPGDpIVAIARAFYDISESDI-YYSSAPIYH----A 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 304 AGTMMCLM---YGATLILASPiFNGKKALEAISRERGTFLYGTPTMFVDILNQPD--FSSYDISTMCGGVIAGSPAPPEL 378
Cdd:PRK13390 208 APLRWCSMvhaLGGTVVLAKR-FDAQATLGHVERYRITVTQMVPTMFVRLLKLDAdvRTRYDVSSLRAVIHAAAPCPVDV 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 379 IRAIINKINmKDLVVAYGTTENSPVTFAHFPEDTVEQKaeSVGRIMPHT----EARIMNMEAGTLaklntpGELCIRGYC 454
Cdd:PRK13390 287 KHAMIDWLG-PIVYEYYSSTEAHGMTFIDSPDWLAHPG--SVGRSVLGDlhicDDDGNELPAGRI------GTVYFERDR 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 455 VMLGYWGEPQKTEEAVDQDKWYWT--GDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKD 532
Cdd:PRK13390 358 LPFRYLNDPEKTAAAQHPAHPFWTtvGDLGSVDEDGYLYLADRKSFMIISGGVNIYPQETENALTMHPAVHDVAVIGVPD 437
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 572879274 533 DRMGEEICACIRLK---DGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 593
Cdd:PRK13390 438 PEMGEQVKAVIQLVegiRGSDELARELIDYTRSRIAHYKAPRSVEFVDELPRTPTGKLVKGLLR 501
|
|
| PRK07787 |
PRK07787 |
acyl-CoA synthetase; Validated |
247-593 |
8.54e-37 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236096 [Multi-domain] Cd Length: 471 Bit Score: 143.21 E-value: 8.54e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 247 IQFTSGTTGSPKGATLSHYNIVNNSNILGERLklhEKTPEQLrMILPNPLYHCLGSVAGTMMCLMYGATLIlaspiFNGK 326
Cdd:PRK07787 133 IVYTSGTTGPPKGVVLSRRAIAADLDALAEAW---QWTADDV-LVHGLPLFHVHGLVLGVLGPLRIGNRFV-----HTGR 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 327 KALEAISRE---RGTFLYGTPTMFVDILNQPD----FSSYDIstmcggVIAGSPAPPELIRAIINKINMKDLVVAYGTTE 399
Cdd:PRK07787 204 PTPEAYAQAlseGGTLYFGVPTVWSRIAADPEaaraLRGARL------LVSGSAALPVPVFDRLAALTGHRPVERYGMTE 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 400 NSPVTFAHFpeDTvEQKAESVGRIMPHTEARIMNmEAGTLAKLN--TPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYW 477
Cdd:PRK07787 278 TLITLSTRA--DG-ERRPGWVGLPLAGVETRLVD-EDGGPVPHDgeTVGELQVRGPTLFDGYLNRPDATAAAFTADGWFR 353
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 478 TGDVATMNEQGFCKIVGR-SKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIrlKDGEETTVEEI 556
Cdd:PRK07787 354 TGDVAVVDPDGMHRIVGReSTDLIKSGGYRIGAGEIETALLGHPGVREAAVVGVPDDDLGQRIVAYV--VGADDVAADEL 431
|
330 340 350
....*....|....*....|....*....|....*..
gi 572879274 557 KAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 593
Cdd:PRK07787 432 IDFVAQQLSVHKRPREVRFVDALPRNAMGKVLKKQLL 468
|
|
| FADD10 |
cd17635 |
adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain ... |
243-589 |
1.71e-36 |
|
adenylate forming domain, fatty acid CoA ligase (FadD10); This family contains long chain fatty acid CoA ligases, including FadD10 which is involved in the synthesis of a virulence-related lipopeptide. FadD10 is a fatty acyl-AMP ligase (FAAL) that transfers fatty acids to an acyl carrier protein. Structures of FadD10 in apo- and complexed form with dodecanoyl-AMP, show a novel open conformation, facilitated by its unique inter-domain and intermolecular interactions, which is critical for the enzyme to carry out the acyl transfer onto the acyl carrier protein (Rv0100) rather than coenzyme A.
Pssm-ID: 341290 [Multi-domain] Cd Length: 340 Bit Score: 139.32 E-value: 1.71e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 243 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKlhEKTPEQLrMILPNPLYHCLGSvAGTMMCLMYGATLILASPI 322
Cdd:cd17635 2 DPLAVIFTSGTTGEPKAVLLANKTFFAVPDILQKEGL--NWVVGDV-TYLPLPATHIGGL-WWILTCLIHGGLCVTGGEN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 323 FNGKKALEAISRERGTFLYGTPTMFVDILNQ-PDFSSYDISTMCggVIAGSPAPPELIRAIINKINMKDLVVAYGTTENS 401
Cdd:cd17635 78 TTYKSLFKILTTNAVTTTCLVPTLLSKLVSElKSANATVPSLRL--IGYGGSRAIAADVRFIEATGLTNTAQVYGLSETG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 402 PVTFAHFPEDTVEqkAESVGRIMPHTEARIMNMEaGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEaVDQDKWYWTGDV 481
Cdd:cd17635 156 TALCLPTDDDSIE--INAVGRPYPGVDVYLAATD-GIAGPSASFGTIWIKSPANMLGYWNNPERTAE-VLIDGWVNTGDL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 482 ATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIrLKDGE--ETTVEEIKAF 559
Cdd:cd17635 232 GERREDGFLFITGRSSESINCGGVKIAPDEVERIAEGVSGVQECACYEISDEEFGELVGLAV-VASAEldENAIRALKHT 310
|
330 340 350
....*....|....*....|....*....|
gi 572879274 560 CKGKISHFKIPKYIVFVTNYPLTISGKIQK 589
Cdd:cd17635 311 IRRELEPYARPSTIVIVTDIPRTQSGKVKR 340
|
|
| MACS_euk |
cd05928 |
Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step ... |
96-595 |
1.76e-36 |
|
Eukaryotic Medium-chain acyl-CoA synthetase (MACS or ACSM); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. The acyl-CoA is a key intermediate in many important biosynthetic and catabolic processes. MACS enzymes are localized to mitochondria. Two murine MACS family proteins are found in liver and kidney. In rodents, a MACS member is detected particularly in the olfactory epithelium and is called O-MACS. O-MACS demonstrates substrate preference for the fatty acid lengths of C6-C12.
Pssm-ID: 341251 [Multi-domain] Cd Length: 530 Bit Score: 143.38 E-value: 1.76e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 96 EDVRLTFAQLKEEVDKAASGLL-SIGLCKGDRLGMWGPNSYAWVLMQLA-----------TAQ--AMELEYVLKKVGCKA 161
Cdd:cd05928 38 DEVKWSFRELGSLSRKAANVLSgACGLQRGDRVAVILPRVPEWWLVNVAcirtglvfipgTIQltAKDILYRLQASKAKC 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 162 LVfpkqfktqqyynVLKQICPEVEnaqpgALKSQrLPDLTTVISV-DAPLPGTLLLDEVVAAGSTRQHLDQLQYNqqfls 240
Cdd:cd05928 118 IV------------TSDELAPEVD-----SVASE-CPSLKTKLLVsEKSRDGWLNFKELLNEASTEHHCVETGSQ----- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 241 chDPINIQFTSGTTGSPKGATLSHynivnnsNILGERLKLHEKtpeQLRMILPNPLYHCLG------SVAGTMMC-LMYG 313
Cdd:cd05928 175 --EPMAIYFTSGTTGSPKMAEHSH-------SSLGLGLKVNGR---YWLDLTASDIMWNTSdtgwikSAWSSLFEpWIQG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 314 ATLILAS-PIFNGKKALEAISRERGTFLYGTPTMFvDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMkDLV 392
Cdd:cd05928 243 ACVFVHHlPRFDPLVILKTLSSYPITTFCGAPTVY-RMLVQQDLSSYKFPSLQHCVTGGEPLNPEVLEKWKAQTGL-DIY 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 393 VAYGTTEnSPVTFAHFpeDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIR-----GYCVMLGYWGEPQKTE 467
Cdd:cd05928 321 EGYGQTE-TGLICANF--KGMKIKPGSMGKASPPYDVQIID-DNGNVLPPGTEGDIGIRvkpirPFGLFSGYVDNPEKTA 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 468 eAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRL-- 545
Cdd:cd05928 397 -ATIRGDFYLTGDRGIMDEDGYFWFMGRADDVINSSGYRIGPFEVESALIEHPAVVESAVVSSPDPIRGEVVKAFVVLap 475
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 572879274 546 ----KDGEETTvEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:cd05928 476 qflsHDPEQLT-KELQQHVKSVTAPYKYPRKVEFVQELPKTVTGKIQRNELRDK 528
|
|
| AA-adenyl-dom |
TIGR01733 |
amino acid adenylation domain; This model represents a domain responsible for the specific ... |
101-527 |
2.03e-36 |
|
amino acid adenylation domain; This model represents a domain responsible for the specific recognition of amino acids and activation as adenylyl amino acids. The reaction catalyzed is aa + ATP -> aa-AMP + PPi. These domains are usually found as components of multi-domain non-ribosomal peptide synthetases and are usually called "A-domains" in that context. A-domains are almost invariably followed by "T-domains" (thiolation domains, pfam00550) to which the amino acid adenylate is transferred as a thiol-ester to a bound pantetheine cofactor with the release of AMP (these are also called peptide carrier proteins, or PCPs. When the A-domain does not represent the first module (corresponding to the first amino acid in the product molecule) it is usually preceded by a "C-domain" (condensation domain, pfam00668) which catalyzes the ligation of two amino acid thiol-esters from neighboring modules. This domain is a subset of the AMP-binding domain found in Pfam (pfam00501) which also hits substrate--CoA ligases and luciferases. Sequences scoring in between trusted and noise for this model may be ambiguous as to whether they activate amino acids or other molecules lacking an alpha amino group.
Pssm-ID: 273779 [Multi-domain] Cd Length: 409 Bit Score: 140.86 E-value: 2.03e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 101 TFAQLKEEVDKAASGLLSI-GLCKGDRLGMWGPNSYAWVLMQLATAQA------ME-------LEYVLKKVGCKALVfpk 166
Cdd:TIGR01733 1 TYRELDERANRLARHLRAAgGVGPGDRVAVLLERSAELVVAILAVLKAgaayvpLDpaypaerLAFILEDAGARLLL--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 167 qfkTQQYYnvlkqicpevenaqpgalkSQRLPDLTTVISVDAPLPGTLLLDEVVAAGST-RQHLDQLQYnqqflschdpi 245
Cdd:TIGR01733 78 ---TDSAL-------------------ASRLAGLVLPVILLDPLELAALDDAPAPPPPDaPSGPDDLAY----------- 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 246 nIQFTSGTTGSPKGATLSHYNIVNNSNILGERLklhEKTPEQlRMILPNPlYHCLGSVAGTMMCLMYGATLILASP--IF 323
Cdd:TIGR01733 125 -VIYTSGSTGRPKGVVVTHRSLVNLLAWLARRY---GLDPDD-RVLQFAS-LSFDASVEEIFGALLAGATLVVPPEdeER 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 324 NGKKALEAISRERG-TFLYGTPTMFVDILNQPDFSSYDISTMCggvIAGSPAPPELIRAIINKINMKDLVVAYGTTENSP 402
Cdd:TIGR01733 199 DDAALLAALIAEHPvTVLNLTPSLLALLAAALPPALASLRLVI---LGGEALTPALVDRWRARGPGARLINLYGPTETTV 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 403 VTFAHFPEDTVEQKAESV--GRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEE--------AVDQ 472
Cdd:TIGR01733 276 WSTATLVDPDDAPRESPVpiGRPLANTRLYVLD-DDLRPVPVGVVGELYIGGPGVARGYLNRPELTAErfvpdpfaGGDG 354
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*.
gi 572879274 473 DKWYWTGDVATMNEQGFCKIVGRSKDMI-IRgGENIYPAELEDFFHTHPKVQEVQV 527
Cdd:TIGR01733 355 ARLYRTGDLVRYLPDGNLEFLGRIDDQVkIR-GYRIELGEIEAALLRHPGVREAVV 409
|
|
| FAAL |
cd05931 |
Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and ... |
82-598 |
8.50e-36 |
|
Fatty acyl-AMP ligase (FAAL); FAAL belongs to the class I adenylate forming enzyme family and is homologous to fatty acyl-coenzyme A (CoA) ligases (FACLs). However, FAALs produce only the acyl adenylate and are unable to perform the thioester-forming reaction, while FACLs perform a two-step catalytic reaction; AMP ligation followed by CoA ligation using ATP and CoA as cofactors. FAALs have insertion motifs between the N-terminal and C-terminal subdomains that distinguish them from the FACLs. This insertion motif precludes the binding of CoA, thus preventing CoA ligation. It has been suggested that the acyl adenylates serve as substrates for multifunctional polyketide synthases to permit synthesis of complex lipids such as phthiocerol dimycocerosate, sulfolipids, mycolic acids, and mycobactin.
Pssm-ID: 341254 [Multi-domain] Cd Length: 547 Bit Score: 141.61 E-value: 8.50e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 82 AQRVPEREALVVLH----EDVRLTFAQLKEEVDKAASGLLSIGLCkGDRLGMWGPNSyawvlmqlataqameLEYVLKKV 157
Cdd:cd05931 3 AAARPDRPAYTFLDdeggREETLTYAELDRRARAIAARLQAVGKP-GDRVLLLAPPG---------------LDFVAAFL 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 158 GCkalvfpkqfktqQYYNVLKQICPE-------------VENAQPGAL----KSQRLPDLTTVISVDAPLPGTLLLDEVV 220
Cdd:cd05931 67 GC------------LYAGAIAVPLPPptpgrhaerlaaiLADAGPRVVlttaAALAAVRAFAASRPAAGTPRLLVVDLLP 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 221 AAGSTRQHLDQLQYNqqflschDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCL 300
Cdd:cd05931 135 DTSAADWPPPSPDPD-------DIAYLQYTSGSTGTPKGVVVTHRNLLANVRQIRRAYGLDPGD----VVVSWLPLYHDM 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 301 GSVAGTMMCLMYGATLILASPI-FNGKKA--LEAISRERGTFLYGtPTmF-----VDILNQPDFSSYDISTMCGGVIAGS 372
Cdd:cd05931 204 GLIGGLLTPLYSGGPSVLMSPAaFLRRPLrwLRLISRYRATISAA-PN-FaydlcVRRVRDEDLEGLDLSSWRVALNGAE 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 373 PAPPELIRAIINKI---NMKDLVV--AYG----------TTENSPVTFAHFPEDTVEQKAE-------------SVGRIM 424
Cdd:cd05931 282 PVRPATLRRFAEAFapfGFRPEAFrpSYGlaeatlfvsgGPPGTGPVVLRVDRDALAGRAVavaaddpaarelvSCGRPL 361
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 425 PHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEE------AVDQDKWYWTGDVATMNEqGFCKIVGRSKD 498
Cdd:cd05931 362 PDQEVRIVDPETGRELPDGEVGEIWVRGPSVASGYWGRPEATAEtfgalaATDEGGWLRTGDLGFLHD-GELYITGRLKD 440
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 499 MIIRGGENIYPAELEDF-FHTHPKVQE--VQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKIS-HFKI-PKYI 573
Cdd:cd05931 441 LIIVRGRNHYPQDIEATaEEAHPALRPgcVAAFSVPDDGEERLVVVAEVERGADPADLAAIAAAIRAAVArEHGVaPADV 520
|
570 580
....*....|....*....|....*..
gi 572879274 574 VFVTN--YPLTISGKIQKFKLREQMER 598
Cdd:cd05931 521 VLVRPgsIPRTSSGKIQRRACRAAYLD 547
|
|
| A_NRPS_Ta1_like |
cd12116 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A ... |
86-587 |
1.33e-35 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the myxovirescin (TA) antibiotic biosynthetic gene in Myxococcus xanthus; TA production plays a role in predation. It also includes the salinosporamide A polyketide synthase which is involved in the biosynthesis of salinosporamide A, a marine microbial metabolite whose chlorine atom is crucial for potent proteasome inhibition and anticancer activity.
Pssm-ID: 341281 [Multi-domain] Cd Length: 470 Bit Score: 139.73 E-value: 1.33e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 86 PEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLAtaqameleyVLKkVGCKALVFP 165
Cdd:cd12116 1 PDATAVR--DDDRSLSYAELDERANRLAARLRARGVGPGDRVAVYLPRSARLVAAMLA---------VLK-AGAAYVPLD 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 166 KQFKTQQYYNVLkqicpevENAQPGALksqrLPDLTTVISVDAPLPGTLLLDEVVAAGSTRQHLDQlqynqqflSCHDPI 245
Cdd:cd12116 69 PDYPADRLRYIL-------EDAEPALV----LTDDALPDRLPAGLPVLLLALAAAAAAPAAPRTPV--------SPDDLA 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 246 NIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQ--------------LRMILPnplyhclgsvagtmmcLM 311
Cdd:cd12116 130 YVIYTSGSTGRPKGVVVSHRNLVNFLHSMRERLGL---GPGDrllavttyafdislLELLLP----------------LL 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 312 YGATLILASP--IFNGKKALEAISRERGTFLYGTPT---MFVDILNQPDFSsydISTMCGgviaGSPAPPELIRAIINKI 386
Cdd:cd12116 191 AGARVVIAPRetQRDPEALARLIEAHSITVMQATPAtwrMLLDAGWQGRAG---LTALCG----GEALPPDLAARLLSRV 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 387 ----NMkdlvvaYGTTENSPVTFAHFPEDtvEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGE 462
Cdd:cd12116 264 gslwNL------YGPTETTIWSTAARVTA--AAGPIPIGRPLANTQVYVLD-AALRPVPPGVPGELYIGGDGVAQGYLGR 334
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 463 PQKTEEAVDQD-------KWYWTGDVATMNEQGFCKIVGRSKDMI-IRgGENIYPAELEDFFHTHPKVQEVQVVgVKDDR 534
Cdd:cd12116 335 PALTAERFVPDpfagpgsRLYRTGDLVRRRADGRLEYLGRADGQVkIR-GHRIELGEIEAALAAHPGVAQAAVV-VREDG 412
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 572879274 535 MGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:cd12116 413 GDRRLVAYVVLKAGAAPDAAALRAHLRATLPAYMVPSAFVRLDALPLTANGKL 465
|
|
| EntF |
COG1020 |
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites ... |
72-559 |
1.88e-33 |
|
EntF, seryl-AMP synthase component of non-ribosomal peptide synthetase [Secondary metabolites biosynthesis, transport and catabolism];
Pssm-ID: 440643 [Multi-domain] Cd Length: 1329 Bit Score: 136.91 E-value: 1.88e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 72 KTVGQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQA---- 147
Cdd:COG1020 476 ATLHELFEAQAARTPDAVAVV--FGDQSLTYAELNARANRLAHHLRALGVGPGDLVGVCLERSLEMVVALLAVLKAgaay 553
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 148 --------ME-LEYVLKKVGCKALVfpkqfkTQQyynvlkqicpevenaqpgALKsQRLPDLT-TVISVDAPLpgtlLLD 217
Cdd:COG1020 554 vpldpaypAErLAYMLEDAGARLVL------TQS------------------ALA-ARLPELGvPVLALDALA----LAA 604
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 218 EVVAAGSTRQHLDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEktpeQLRMilpnPLY 297
Cdd:COG1020 605 EPATNPPVPVTPDDLAY------------VIYTSGSTGRPKGVMVEHRALVNLLAWMQRRYGLGP----GDRV----LQF 664
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 298 HCLG---SVAGTMMCLMYGATLILASP--IFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMcggVIAGS 372
Cdd:COG1020 665 ASLSfdaSVWEIFGALLSGATLVLAPPeaRRDPAALAELLARHRVTVLNLTPSLLRALLDAAPEALPSLRLV---LVGGE 741
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 373 PAPPELIRAIINKINMKDLVVAYGTTENSpVTFAHFPEDTVEQKAESV--GRIMPHTEARIMNmEAGTLAKLNTPGELCI 450
Cdd:COG1020 742 ALPPELVRRWRARLPGARLVNLYGPTETT-VDSTYYEVTPPDADGGSVpiGRPIANTRVYVLD-AHLQPVPVGVPGELYI 819
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 451 RGYCVMLGYWGEPQKTEEA-------VDQDKWYWTGDVATMNEQG---FckiVGRSKDMI-IRGgeniY---PAELEDFF 516
Cdd:COG1020 820 GGAGLARGYLNRPELTAERfvadpfgFPGARLYRTGDLARWLPDGnleF---LGRADDQVkIRG----FrieLGEIEAAL 892
|
490 500 510 520
....*....|....*....|....*....|....*....|....
gi 572879274 517 HTHPKVQEVqVVGVKDDRMGEE-ICACIRLKDGEETTVEEIKAF 559
Cdd:COG1020 893 LQHPGVREA-VVVAREDAPGDKrLVAYVVPEAGAAAAAALLRLA 935
|
|
| A_NRPS_Sfm_like |
cd12115 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene ... |
78-592 |
2.98e-33 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the saframycin A gene cluster from Streptomyces lavendulae which implicates the NRPS system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. It also includes saframycin Mx1 produced by Myxococcus xanthus NRPS.
Pssm-ID: 341280 [Multi-domain] Cd Length: 447 Bit Score: 132.44 E-value: 2.98e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVVlhEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGmwgpnsyawVLMQLATAQAMELEYVLKKV 157
Cdd:cd12115 5 VEAQAARTPDAIALVC--GDESLTYAELNRRANRLAARLRAAGVGPESRVG---------VCLERTPDLVVALLAVLKAG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 158 GCKALVFPkqfktqqyynvlkqicpevenAQPgalksqrlPDLTTVISVDAPLPgtLLLDEvvaagstrqhLDQLQYnqq 237
Cdd:cd12115 74 AAYVPLDP---------------------AYP--------PERLRFILEDAQAR--LVLTD----------PDDLAY--- 109
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 238 flschdpinIQFTSGTTGSPKGATLSHYNIVNnsnILgeRLKLHEKTPEQLRMILpnplyhclgsvAGTMMC-------- 309
Cdd:cd12115 110 ---------VIYTSGSTGRPKGVAIEHRNAAA---FL--QWAAAAFSAEELAGVL-----------ASTSICfdlsvfel 164
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 310 ---LMYGATLILASPIFngkkALEAISRERGTFLYGT-PTMFVDILNQPDFSSyDISTMCggvIAGSPAPPELIRAIINK 385
Cdd:cd12115 165 fgpLATGGKVVLADNVL----ALPDLPAAAEVTLINTvPSAAAELLRHDALPA-SVRVVN---LAGEPLPRDLVQRLYAR 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 386 INMKDLVVAYGTTENSPVTFAHfPEDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQK 465
Cdd:cd12115 237 LQVERVVNLYGPSEDTTYSTVA-PVPPGASGEVSIGRPLANTQAYVLD-RALQPVPLGVPGELYIGGAGVARGYLGRPGL 314
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 466 TEEAVDQD------KWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEI 539
Cdd:cd12115 315 TAERFLPDpfgpgaRLYRTGDLVRWRPDGLLEFLGRADNQVKVRGFRIELGEIEAALRSIPGVREAVVVAIGDAAGERRL 394
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 572879274 540 CACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKL 592
Cdd:cd12115 395 VAYIVAEPGAAGLVEDLRRHLGTRLPAYMVPSRFVRLDALPLTPNGKIDRSAL 447
|
|
| A_NRPS_Bac |
cd17655 |
bacitracin synthetase and related proteins; This family of the adenylation (A) domain of ... |
247-594 |
3.27e-33 |
|
bacitracin synthetase and related proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetases 1, 2, and 3 (BA1, also known as ATP-dependent cysteine adenylase or cysteine activase, BA2, also known as ATP-dependent lysine adenylase or lysine activase, and BA3, also known as ATP-dependent isoleucine adenylase or isoleucine activase) in Bacilli. Bacitracin is a mixture of related cyclic peptides used as a polypeptide antibiotic. This family also includes gramicidin synthetase 1 involved in synthesis of the cyclic peptide antibiotic gramicidin S via activation of phenylalanine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341310 [Multi-domain] Cd Length: 490 Bit Score: 133.22 E-value: 3.27e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 247 IQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKtpeqLRMILPNPLYHCLgSVAGTMMCLMYGATLILA--SPIFN 324
Cdd:cd17655 142 VIYTSGSTGKPKGVMIEHRGVVNLVEWANKVIYQGEH----LRVALFASISFDA-SVTEIFASLLSGNTLYIVrkETVLD 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 325 GKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMcggVIAGSPAPPELIRAIINKINMK-DLVVAYGTTENSpV 403
Cdd:cd17655 217 GQALTQYIRQNRITIIDLTPAHLKLLDAADDSEGLSLKHL---IVGGEALSTELAKKIIELFGTNpTITNAYGPTETT-V 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 404 TFAHFPEDTVEQKAESV--GRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEA------VDQDKW 475
Cdd:cd17655 293 DASIYQYEPETDQQVSVpiGKPLGNTRIYILD-QYGRPQPVGVAGELYIGGEGVARGYLNRPELTAEKfvddpfVPGERM 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 476 YWTGDVATMNEQGFCKIVGRSKDMI-IRGgeniYPAELEDFFH---THPKVQEVQVVGVKDDRMGEEICACIRLKdgEET 551
Cdd:cd17655 372 YRTGDLARWLPDGNIEFLGRIDHQVkIRG----YRIELGEIEArllQHPDIKEAVVIARKDEQGQNYLCAYIVSE--KEL 445
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 572879274 552 TVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 594
Cdd:cd17655 446 PVAQLREFLARELPDYMIPSYFIKLDEIPLTPNGKVDRKALPE 488
|
|
| MACS_like_3 |
cd05971 |
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ... |
243-593 |
3.87e-33 |
|
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.
Pssm-ID: 341275 [Multi-domain] Cd Length: 439 Bit Score: 132.17 E-value: 3.87e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 243 DPINIQFTSGTTGSPKGATLSHYNIVNNsniLGERLKLHEKTPEQLRMILPNPLYHCLGSVAGTMMCLMYGATLILA--S 320
Cdd:cd05971 89 DPALIIYTSGTTGPPKGALHAHRVLLGH---LPGVQFPFNLFPRDGDLYWTPADWAWIGGLLDVLLPSLYFGVPVLAhrM 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 321 PIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELI----RAIINKINMkdlvvAYG 396
Cdd:cd05971 166 TKFDPKAALDLMSRYGVTTAFLPPTALKMMRQQGEQLKHAQVKLRAIATGGESLGEELLgwarEQFGVEVNE-----FYG 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 397 TTE------NSPVTFahfpedtvEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYC--VMLGYWGEPQKTEE 468
Cdd:cd05971 241 QTEcnlvigNCSALF--------PIKPGSMGKPIPGHRVAIVD-DNGTPLPPGEVGEIAVELPDpvAFLGYWNNPSATEK 311
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 469 AVDQDkWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDG 548
Cdd:cd05971 312 KMAGD-WLLTGDLGRKDSDGYFWYVGRDDDVITSSGYRIGPAEIEECLLKHPAVLMAAVVGIPDPIRGEIVKAFVVLNPG 390
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 572879274 549 EETT---VEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 593
Cdd:cd05971 391 ETPSdalAREIQELVKTRLAAHEYPREIEFVNELPRTATGKIRRRELR 438
|
|
| PLN02574 |
PLN02574 |
4-coumarate--CoA ligase-like |
242-600 |
4.45e-33 |
|
4-coumarate--CoA ligase-like
Pssm-ID: 215312 [Multi-domain] Cd Length: 560 Bit Score: 133.81 E-value: 4.45e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 242 HDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGE-RLKLHEKTPEQLRMILPNPLYHCLGSVAGTMMCLMYGATLILAS 320
Cdd:PLN02574 198 DDVAAIMYSSGTTGASKGVVLTHRNLIAMVELFVRfEASQYEYPGSDNVYLAALPMFHIYGLSLFVVGLLSLGSTIVVMR 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 321 PiFNGKKALEAISRERGTFLYGTPTMFVDILNQPdfssydiSTMCGGVI--------AGSPAPPELIRAIINKINMKDLV 392
Cdd:PLN02574 278 R-FDASDMVKVIDRFKVTHFPVVPPILMALTKKA-------KGVCGEVLkslkqvscGAAPLSGKFIQDFVQTLPHVDFI 349
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 393 VAYGTTENSPVTFAHFPEDTVeQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQ 472
Cdd:PLN02574 350 QGYGMTESTAVGTRGFNTEKL-SKYSSVGLLAPNMQAKVVDWSTGCLLPPGNCGELWIQGPGVMKGYLNNPKATQSTIDK 428
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 473 DKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETT 552
Cdd:PLN02574 429 DGWLRTGDIAYFDEDGYLYIVDRLKEIIKYKGFQIAPADLEAVLISHPEIIDAAVTAVPDKECGEIPVAFVVRRQGSTLS 508
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 572879274 553 VEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIqkfkLREQMERHL 600
Cdd:PLN02574 509 QEAVINYVAKQVAPYKKVRKVVFVQSIPKSPAGKI----LRRELKRSL 552
|
|
| PRK05620 |
PRK05620 |
long-chain fatty-acid--CoA ligase; |
100-598 |
6.79e-33 |
|
long-chain fatty-acid--CoA ligase;
Pssm-ID: 180167 [Multi-domain] Cd Length: 576 Bit Score: 133.37 E-value: 6.79e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 100 LTFAQLKEEVDKAASGLL-SIGLCKGDRLGMWGPNSyawvlmqlatAQAMEleyVLKKVGCKALVF-P--KQFKTQQYYN 175
Cdd:PRK05620 39 TTFAAIGARAAALAHALHdELGITGDQRVGSMMYNC----------AEHLE---VLFAVACMGAVFnPlnKQLMNDQIVH 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 176 VLKQICPEVENAQPgALKSQRLPDLTTVISVDAPL-PGTLLLDEvvAAGSTRQHLDQLQYNQQF-----------LSCHD 243
Cdd:PRK05620 106 IINHAEDEVIVADP-RLAEQLGEILKECPCVRAVVfIGPSDADS--AAAHMPEGIKVYSYEALLdgrstvydwpeLDETT 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 244 PINIQFTSGTTGSPKGATLSHYNIVNNSNIL--GERLKLHEKTPeqlrMILPNPLYHCLgSVAGTMMCLMYGATLILASP 321
Cdd:PRK05620 183 AAAICYSTGTTGAPKGVVYSHRSLYLQSLSLrtTDSLAVTHGES----FLCCVPIYHVL-SWGVPLAAFMSGTPLVFPGP 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 322 IFNGKKALEAISRERGTFLYGTPTMFVDIL-----NQPDFSSydISTMCGGviaGSPAPPELIRAIINKINMkDLVVAYG 396
Cdd:PRK05620 258 DLSAPTLAKIIATAMPRVAHGVPTLWIQLMvhylkNPPERMS--LQEIYVG---GSAVPPILIKAWEERYGV-DVVHVWG 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 397 TTENSPV-TFAHFPE----DTVEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTE---- 467
Cdd:PRK05620 332 MTETSPVgTVARPPSgvsgEARWAYRVSQGRFPASLEYRIVNDGQVMESTDRNEGEIQVRGNWVTASYYHSPTEEGggaa 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 468 -----EAVD-------QDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRM 535
Cdd:PRK05620 412 stfrgEDVEdandrftADGWLRTGDVGSVTRDGFLTIHDRARDVIRSGGEWIYSAQLENYIMAAPEVVECAVIGYPDDKW 491
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 572879274 536 GEEICACIRLKDGEE---TTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMER 598
Cdd:PRK05620 492 GERPLAVTVLAPGIEptrETAERLRDQLRDRLPNWMLPEYWTFVDEIDKTSVGKFDKKDLRQHLAD 557
|
|
| PRK13383 |
PRK13383 |
acyl-CoA synthetase; Provisional |
52-596 |
3.17e-32 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 139531 [Multi-domain] Cd Length: 516 Bit Score: 130.50 E-value: 3.17e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 52 STPIGGLSYVQGCTKKHLNSKTVgqcLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWG 131
Cdd:PRK13383 18 PSPRAVLRLLREASRGGTNPYTL---LAVTAARWPGRTAII--DDDGALSYRELQRATESLARRLTRDGVAPGRAVGVMC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 132 PNSYAWVlmqlATAQAMELeyvlkkVGCKALVFPKQFKTqqyynvlkqicpeveNAQPGALKSQRLpdlTTVISVDAplp 211
Cdd:PRK13383 93 RNGRGFV----TAVFAVGL------LGADVVPISTEFRS---------------DALAAALRAHHI---STVVADNE--- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 212 gtlLLDEVVAAGSTRQHLDQLQYNQQFLSCHDPIN-----IQFTSGTTGSPKGATLSHY--NIVNNSNILGERLKLHEKT 284
Cdd:PRK13383 142 ---FAERIAGADDAVAVIDPATAGAEESGGRPAVAapgriVLLTSGTTGKPKGVPRAPQlrSAVGVWVTILDRTRLRTGS 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 285 peqlRMILPNPLYHCLGsVAGTMMCLMYGATlILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTM 364
Cdd:PRK13383 219 ----RISVAMPMFHGLG-LGMLMLTIALGGT-VLTHRHFDAEAALAQASLHRADAFTAVPVVLARILELPPRVRARNPLP 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 365 CGGVI--AGSPAPPELIRAIINKINmKDLVVAYGTTENSPVTFAHfPEDtVEQKAESVGRIMPHTEARIMNMEAGTLAKL 442
Cdd:PRK13383 293 QLRVVmsSGDRLDPTLGQRFMDTYG-DILYNGYGSTEVGIGALAT-PAD-LRDAPETVGKPVAGCPVRILDRNNRPVGPR 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 443 NTpGELCIRGYCVMLGYWGEPQKteeAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKV 522
Cdd:PRK13383 370 VT-GRIFVGGELAGTRYTDGGGK---AV-VDGMTSTGDMGYLDNAGRLFIVGREDDMIISGGENVYPRAVENALAAHPAV 444
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 572879274 523 QEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIqkfkLREQM 596
Cdd:PRK13383 445 ADNAVIGVPDERFGHRLAAFVVLHPGSGVDAAQLRDYLKDRVSRFEQPRDINIVSSIPRNPTGKV----LRKEL 514
|
|
| A_NRPS_VisG_like |
cd17651 |
similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) ... |
82-587 |
4.08e-31 |
|
similar to adenylation domain of virginiamycin S synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes virginiamycin S synthetase (VisG) in Streptomyces virginiae; VisG is involved in virginiamycin S (VS) biosynthesis as the provider of an L-pheGly molecule, a highly specific substrate for the last condensation step by VisF. This family also includes linear gramicidin synthetase B (LgrB) in Brevibacillus brevis. Substrate specificity analysis using residues of the substrate-binding pockets of all 16 adenylation domains has shown good agreement of the substrate amino acids predicted with the sequence of linear gramicidin. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341306 [Multi-domain] Cd Length: 491 Bit Score: 127.07 E-value: 4.08e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 82 AQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAmELEYVLKKVGcka 161
Cdd:cd17651 5 AARTPDAPALV--AEGRRLTYAELDRRANRLAHRLRARGVGPGDLVALCARRSAELVVALLAILKA-GAAYVPLDPA--- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 162 lvFPKQFKTQqyynVLKQICPEVENAQPGALksqrlPDLTTVISVDAPLPGTLLLDEVVAAGSTRQHLDQLQYnqqflsc 241
Cdd:cd17651 79 --YPAERLAF----MLADAGPVLVLTHPALA-----GELAVELVAVTLLDQPGAAAGADAEPDPALDADDLAY------- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 242 hdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLrmilpnplYHCLG---SVAGTMMCLMYGATLIL 318
Cdd:cd17651 141 -----VIYTSGSTGRPKGVVMPHRSLANLVAWQARASSLGPGARTLQ--------FAGLGfdvSVQEIFSTLCAGATLVL 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 319 ASP-IFNGKKALEAISRERG---TFLygtPTMFVD-ILNQPDFSSYDISTMCGGVIAGSPAPP-ELIRAIINKINMKDLV 392
Cdd:cd17651 208 PPEeVRTDPPALAAWLDEQRisrVFL---PTVALRaLAEHGRPLGVRLAALRYLLTGGEQLVLtEDLREFCAGLPGLRLH 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 393 VAYGTTENSPVTFAHFPEDTVEQKAE-SVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVD 471
Cdd:cd17651 285 NHYGPTETHVVTALSLPGDPAAWPAPpPIGRPIDNTRVYVLD-AALRPVPPGVPGELYIGGAGLARGYLNRPELTAERFV 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 472 QDKW------YWTGDVATMNEQGFCKIVGRSKDMI-IRGgENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIR 544
Cdd:cd17651 364 PDPFvpgarmYRTGDLARWLPDGELEFLGRADDQVkIRG-FRIELGEIEAALARHPGVREAVVLAREDRPGEKRLVAYVV 442
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 572879274 545 LKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:cd17651 443 GDPEAPVDAAELRAALATHLPEYMVPSAFVLLDALPLTPNGKL 485
|
|
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
240-587 |
7.03e-31 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 128.93 E-value: 7.03e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 240 SCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHektPEQlrmILPN--PLYHCLGSVAGTMMCLMYGATLI 317
Cdd:PRK06814 791 DPDDPAVILFTSGSEGTPKGVVLSHRNLLANRAQVAARIDFS---PED---KVFNalPVFHSFGLTGGLVLPLLSGVKVF 864
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 318 L-ASPIfNGKKALEAISRERGTFLYGTPTMfvdiLN------QP-DFSS--YdistmcggVIAGSpappELIRAIINKIN 387
Cdd:PRK06814 865 LyPSPL-HYRIIPELIYDTNATILFGTDTF----LNgyaryaHPyDFRSlrY--------VFAGA----EKVKEETRQTW 927
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 388 MKDLVV----AYGTTENSPV----TFAHFpedtveqKAESVGRIMPHTEARIMNMEAgtlakLNTPGELCIRGYCVMLGY 459
Cdd:PRK06814 928 MEKFGIrileGYGVTETAPVialnTPMHN-------KAGTVGRLLPGIEYRLEPVPG-----IDEGGRLFVRGPNVMLGY 995
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 460 WGE--PQKTEEAVDqdKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHT-HPKVQEVqVVGVKDDRMG 536
Cdd:PRK06814 996 LRAenPGVLEPPAD--GWYDTGDIVTIDEEGFITIKGRAKRFAKIAGEMISLAAVEELAAElWPDALHA-AVSIPDARKG 1072
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 572879274 537 EEIcacIRLKDGEETTVEEIKAFCKGK-ISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:PRK06814 1073 ERI---ILLTTASDATRAAFLAHAKAAgASELMVPAEIITIDEIPLLGTGKI 1121
|
|
| ACSBG_like |
cd05933 |
Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very ... |
100-595 |
7.91e-31 |
|
Bubblegum-like very long-chain fatty acid CoA synthetase (VL-FACS); This family of very long-chain fatty acid CoA synthetase is named bubblegum because Drosophila melanogaster mutant bubblegum (BGM) has elevated levels of very-long-chain fatty acids (VLCFA) caused by a defective gene of this family. The human homolog (hsBG) has been characterized as a very long chain fatty acid CoA synthetase that functions specifically in the brain; hsBG may play a central role in brain VLCFA metabolism and myelinogenesis. VL-FACS is involved in the first reaction step of very long chain fatty acid degradation. It catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341256 [Multi-domain] Cd Length: 596 Bit Score: 127.47 E-value: 7.91e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 100 LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAMELeyvlkKVGCKALVFPKQFktqQY--YNVL 177
Cdd:cd05933 9 LTYKEYYEACRQAAKAFLKLGLERFHGVGILGFNSPEWFIAAVGAIFAGGI-----AVGIYTTNSPEAC---QYvaETSE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 178 KQICPeVENAQPGALKSQ---RLPDLTTVISVDAPL----PGTLLLDEVVAAG--STRQHLDQLQYNQQFLSCHDPIniq 248
Cdd:cd05933 81 ANILV-VENQKQLQKILQiqdKLPHLKAIIQYKEPLkekePNLYSWDEFMELGrsIPDEQLDAIISSQKPNQCCTLI--- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 249 FTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMILPNPLYHclgsVAGTMM----CLMYGATLILASPIfN 324
Cdd:cd05933 157 YTSGTTGMPKGVMLSHDNITWTAKAASQHMDLRPATVGQESVVSYLPLSH----IAAQILdiwlPIKVGGQVYFAQPD-A 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 325 GKKALEAISRE-RGTFLYGTPTMFVDIL----------------------------NQPDFSSYDISTMCGGVI------ 369
Cdd:cd05933 232 LKGTLVKTLREvRPTAFMGVPRVWEKIQekmkavgaksgtlkrkiaswakgvgletNLKLMGGESPSPLFYRLAkklvfk 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 370 ----------------AGSPAPPELIRAIINkINMKdLVVAYGTTENSPvtfAHFPEDTVEQKAESVGRIMPHTEARIMN 433
Cdd:cd05933 312 kvrkalgldrcqkfftGAAPISRETLEFFLS-LNIP-IMELYGMSETSG---PHTISNPQAYRLLSCGKALPGCKTKIHN 386
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 434 MEAgtlaklNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIR-GGENIYPAEL 512
Cdd:cd05933 387 PDA------DGIGEICFWGRHVFMGYLNMEDKTEEAIDEDGWLHSGDLGKLDEDGFLYITGRIKELIITaGGENVPPVPI 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 513 EDFFHTH-PKVQEVQVVGVK---------------------DDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFkIP 570
Cdd:cd05933 461 EDAVKKElPIISNAMLIGDKrkflsmlltlkcevnpetgepLDELTEEAIEFCRKLGSQATRVSEIAGGKDPKVYEA-IE 539
|
570 580
....*....|....*....|....*
gi 572879274 571 KYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:cd05933 540 EGIKRVNKKAISNAQKIQKWVILEK 564
|
|
| MACS_like_2 |
cd05973 |
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ... |
243-593 |
8.44e-31 |
|
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.
Pssm-ID: 341277 [Multi-domain] Cd Length: 437 Bit Score: 125.32 E-value: 8.44e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 243 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQLRMILPNP-----LYHclgSVAGTMmcLMYGATLI 317
Cdd:cd05973 89 DPFVMMFTSGTTGLPKGVPVPLRALAAFGAYLRDAVDL---RPEDSFWNAADPgwaygLYY---AITGPL--ALGHPTIL 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 318 LASPiFNGKKALEAISRERGTFLYGTPTMFVDILNqpdfSSYDISTMCGGVI-----AGSPAPPELIRAIINKIN--MKD 390
Cdd:cd05973 161 LEGG-FSVESTWRVIERLGVTNLAGSPTAYRLLMA----AGAEVPARPKGRLrrvssAGEPLTPEVIRWFDAALGvpIHD 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 391 lvvAYGTTE-NSPVTFAHFPEDTVeqKAESVGRIMPHTEARIMNMEAGTLAKlNTPGELCIRGYCVML----GYWGEPQK 465
Cdd:cd05973 236 ---HYGQTElGMVLANHHALEHPV--HAGSAGRAMPGWRVAVLDDDGDELGP-GEPGRLAIDIANSPLmwfrGYQLPDTP 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 466 TEEAvdqdKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRL 545
Cdd:cd05973 310 AIDG----GYYLTGDTVEFDPDGSFSFIGRADDVITMSGYRIGPFDVESALIEHPAVAEAAVIGVPDPERTEVVKAFVVL 385
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 572879274 546 KDGEETTVE---EIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 593
Cdd:cd05973 386 RGGHEGTPAladELQLHVKKRLSAHAYPRTIHFVDELPKTPSGKIQRFLLR 436
|
|
| A_NRPS_AB3403-like |
cd17646 |
Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or ... |
78-587 |
1.09e-29 |
|
Peptide Synthetase; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341301 [Multi-domain] Cd Length: 488 Bit Score: 122.77 E-value: 1.09e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQA---------- 147
Cdd:cd17646 4 VAEQAARTPDAPAVV--DEGRTLTYRELDERANRLAHLLRARGVGPEDRVAVLLPRSADLVVALLAVLKAgaaylpldpg 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 148 ---MELEYVLKKVGCKALVfpkqfktqqyynvlkqicpeVENAQPGALKsqRLPDLTTVISVDAPLPGTLLLDEVVaags 224
Cdd:cd17646 82 ypaDRLAYMLADAGPAVVL--------------------TTADLAARLP--AGGDVALLGDEALAAPPATPPLVPP---- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 225 trqHLDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYNIVNNsnIL----------GERLkLHeKTPeqlrmilpn 294
Cdd:cd17646 136 ---RPDNLAY------------VIYTSGSTGRPKGVMVTHAGIVNR--LLwmqdeyplgpGDRV-LQ-KTP--------- 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 295 plyhcLG---SVAGTMMCLMYGATLILASPIFNGKKA--LEAISRERGTFLYGTPTMFVDILNQPDFSSydistmCGG-- 367
Cdd:cd17646 188 -----LSfdvSVWELFWPLVAGARLVVARPGGHRDPAylAALIREHGVTTCHFVPSMLRVFLAEPAAGS------CASlr 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 368 --VIAGSPAPPELIRAIINKINMKdLVVAYGTTENSpVTFAHFP-EDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNT 444
Cdd:cd17646 257 rvFCSGEALPPELAARFLALPGAE-LHNLYGPTEAA-IDVTHWPvRGPAETPSVPIGRPVPNTRLYVLD-DALRPVPVGV 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 445 PGELCIRGYCVMLGYWGEPQKTEEAVDQD------KWYWTGDVATMNEQGFCKIVGRSKDMI-IRgGENIYPAELEDFFH 517
Cdd:cd17646 334 PGELYLGGVQLARGYLGRPALTAERFVPDpfgpgsRMYRTGDLARWRPDGALEFLGRSDDQVkIR-GFRVEPGEIEAALA 412
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 572879274 518 THPKVQEVQVVGVKDDRMGEEICA-CIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:cd17646 413 AHPAVTHAVVVARAAPAGAARLVGyVVPAAGAAGPDTAALRAHLAERLPEYMVPAAFVVLDALPLTANGKL 483
|
|
| PRK07445 |
PRK07445 |
O-succinylbenzoic acid--CoA ligase; Reviewed |
369-602 |
1.19e-29 |
|
O-succinylbenzoic acid--CoA ligase; Reviewed
Pssm-ID: 236019 [Multi-domain] Cd Length: 452 Bit Score: 122.03 E-value: 1.19e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 369 IAGSPAPPEL-IRAIINKINmkdLVVAYGTTENSPVTFAHFPEDTVeQKAESVGRIMPHTEARIMNmeagtlaklNTPGE 447
Cdd:PRK07445 237 LGGAPAWPSLlEQARQLQLR---LAPTYGMTETASQIATLKPDDFL-AGNNSSGQVLPHAQITIPA---------NQTGN 303
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 448 LCIRGYCVMLGYWgePQKteeaVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQV 527
Cdd:PRK07445 304 ITIQAQSLALGYY--PQI----LDSQGIFETDDLGYLDAQGYLHILGRNSQKIITGGENVYPAEVEAAILATGLVQDVCV 377
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 572879274 528 VGVKDDRMGEEICACIRLKDGeETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMERHLNL 602
Cdd:PRK07445 378 LGLPDPHWGEVVTAIYVPKDP-SISLEELKTAIKDQLSPFKQPKHWIPVPQLPRNPQGKINRQQLQQIAVQRLGL 451
|
|
| A_NRPS_TubE_like |
cd05906 |
The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) ... |
95-598 |
1.67e-29 |
|
The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPSs that synthesize toxins and antitumor agents; for example, TubE for Tubulysine, CrpA for cryptophycin, TdiA for terrequinone A, KtzG for kutzneride, and Vlm1/Vlm2 for Valinomycin. Nonribosomal peptide synthetases are large multifunctional enzymes which synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341232 [Multi-domain] Cd Length: 540 Bit Score: 122.78 E-value: 1.67e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 95 HEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRlgmwgpnsyawVLMQLATAQamelEYVLKKVGC------KALVFPKQF 168
Cdd:cd05906 35 GSEEFQSYQDLLEDARRLAAGLRQLGLRPGDS-----------VILQFDDNE----DFIPAFWACvlagfvPAPLTVPPT 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 169 KTQQYYNVLKqicpeVENA-----QPGALKSQRL-PDLTTvISVDAPLPGtlllDEVVAAGSTRQHLDQLQYNQQflSCH 242
Cdd:cd05906 100 YDEPNARLRK-----LRHIwqllgSPVVLTDAELvAEFAG-LETLSGLPG----IRVLSIEELLDTAADHDLPQS--RPD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 243 DPINIQFTSGTTGSPKGATLSHYNIVNnsnilgeRLK----LHEKTPEQLRMilpN--PLYHCLGSVAGTMMCLMYG--- 313
Cdd:cd05906 168 DLALLMLTSGSTGFPKAVPLTHRNILA-------RSAgkiqHNGLTPQDVFL---NwvPLDHVGGLVELHLRAVYLGcqq 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 314 ----ATLILASPIfngkKALEAISRERGT------FLYgtpTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAII 383
Cdd:cd05906 238 vhvpTEEILADPL----RWLDLIDRYRVTitwapnFAF---ALLNDLLEEIEDGTWDLSSLRYLVNAGEAVVAKTIRRLL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 384 N-----KINMKDLVVAYGTTEN-SPVTFAH-FPEDTVEQKAE--SVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYC 454
Cdd:cd05906 311 RllepyGLPPDAIRPAFGMTETcSGVIYSRsFPTYDHSQALEfvSLGRPIPGVSMRIVD-DEGQLLPEGEVGRLQVRGPV 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 455 VMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEqGFCKIVGRSKDMIIRGGENIYPAELEDFfhthpkVQEVQVV------ 528
Cdd:cd05906 390 VTKGYYNNPEANAEAFTEDGWFRTGDLGFLDN-GNLTITGRTKDTIIVNGVNYYSHEIEAA------VEEVPGVepsfta 462
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 529 --GVKDDRMGEEICAC-----IRLKDGEETTVEEIkafcKGKISH-FKI-PKYIVFV--TNYPLTISGKIQKFKLREQME 597
Cdd:cd05906 463 afAVRDPGAETEELAIffvpeYDLQDALSETLRAI----RSVVSReVGVsPAYLIPLpkEEIPKTSLGKIQRSKLKAAFE 538
|
.
gi 572879274 598 R 598
Cdd:cd05906 539 A 539
|
|
| LC-FACS_euk |
cd05927 |
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are ... |
100-529 |
1.87e-29 |
|
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS); The members of this family are eukaryotic fatty acid CoA synthetases that activate fatty acids with chain lengths of 12 to 20. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells.
Pssm-ID: 341250 [Multi-domain] Cd Length: 545 Bit Score: 122.71 E-value: 1.87e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 100 LTFAQLKEEVDKAASGLLSIGLC--KGDRLGMWGPNSYAWVL-MQLATAQAM------------ELEYVLKKVGCKALVF 164
Cdd:cd05927 6 ISYKEVAERADNIGSALRSLGGKpaPASFVGIYSINRPEWIIsELACYAYSLvtvplydtlgpeAIEYILNHAEISIVFC 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 165 PKQFKTQQYYNVLKQICPEVENAQPGAlksqrlPDLTTVISvdaplpgtllldevvaagstrqhldqlqynqqflschdp 244
Cdd:cd05927 86 DAGVKVYSLEEFEKLGKKNKVPPPPPK------PEDLATIC--------------------------------------- 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 245 iniqFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMILPNPLYHCLGSVAgTMMCLMYGA---------- 314
Cdd:cd05927 121 ----YTSGTTGNPKGVMLTHGNIVSNVAGVFKILEILNKINPTDVYISYLPLAHIFERVV-EALFLYHGAkigfysgdir 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 315 -----------TLILASP---------IFNG-------KKAL--EAISRERGTFLYG--TPTMFVD--ILNQpdfssydI 361
Cdd:cd05927 196 lllddikalkpTVFPGVPrvlnriydkIFNKvqakgplKRKLfnFALNYKLAELRSGvvRASPFWDklVFNK-------I 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 362 STMCGG----VIAGS-PAPPELI---RAIinkinMKDLVV-AYGTTENSPVTFAHFPEDTVeqkAESVGRIMPHTEARIM 432
Cdd:cd05927 269 KQALGGnvrlMLTGSaPLSPEVLeflRVA-----LGCPVLeGYGQTECTAGATLTLPGDTS---VGHVGGPLPCAEVKLV 340
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 433 NM-EAGTLAKLNTP-GELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRGGENIYP 509
Cdd:cd05927 341 DVpEMNYDAKDPNPrGEVCIRGPNVFSGYYKDPEKTAEALDEDGWLHTGDIGEWLPNGTLKIIDRKKNIFkLSQGEYVAP 420
|
490 500
....*....|....*....|
gi 572879274 510 AELEDFFHTHPKVQEVQVVG 529
Cdd:cd05927 421 EKIENIYARSPFVAQIFVYG 440
|
|
| ACS-like |
cd17634 |
acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the ... |
73-587 |
2.08e-29 |
|
acetate-CoA ligase; This family includes acyl- and aryl-CoA ligases, as well as the adenylation domain of nonribosomal peptide synthetases and firefly luciferases. The adenylate-forming enzymes catalyze an ATP-dependent two-step reaction to first activate a carboxylate substrate as an adenylate and then transfer the carboxylate to the pantetheine group of either coenzyme A or an acyl-carrier protein. The active site of the domain is located at the interface of a large N-terminal subdomain and a smaller C-terminal subdomain.
Pssm-ID: 341289 [Multi-domain] Cd Length: 587 Bit Score: 123.07 E-value: 2.08e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 73 TVGQCLETTAQRVPEREALVVLHED---VR-LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQ-- 146
Cdd:cd17634 54 LAANALDRHLRENGDRTAIIYEGDDtsqSRtISYRELHREVCRFAGTLLDLGVKKGDRVAIYMPMIPEAAVAMLACARig 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 147 -----------AMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEVENAQpgalksqrLPDLTTVISVD---APLPG 212
Cdd:cd17634 134 avhsvifggfaPEAVAGRIIDSSSRLLITADGGVRAGRSVPLKKNVDDALNPN--------VTSVEHVIVLKrtgSDIDW 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 213 T----LLLDEVVAAGSTRqhldqlqYNQQFLSCHDPINIQFTSGTTGSPKGATLSHynivnnsnilGERLKLHEKTPEQL 288
Cdd:cd17634 206 QegrdLWWRDLIAKASPE-------HQPEAMNAEDPLFILYTSGTTGKPKGVLHTT----------GGYLVYAATTMKYV 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 289 RMILPNPLYHCLGSVaGTMMC---LMYGATLILA-SPIFNGK-------KALEAISRERGTFLYGTPTMFVDILNQPD-- 355
Cdd:cd17634 269 FDYGPGDIYWCTADV-GWVTGhsyLLYGPLACGAtTLLYEGVpnwptpaRMWQVVDKHGVNILYTAPTAIRALMAAGDda 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 356 FSSYDISTMCGGVIAGSPAPPELIRAIINKINMKD--LVVAYGTTENSPVTFAHFPeDTVEQKAESVGRIMPHTEARIMN 433
Cdd:cd17634 348 IEGTDRSSLRILGSVGEPINPEAYEWYWKKIGKEKcpVVDTWWQTETGGFMITPLP-GAIELKAGSATRPVFGVQPAVVD 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 434 MEaGTLAKLNTPGELCIRGYC--VMLGYWGEPQKTEEAVDQ--DKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYP 509
Cdd:cd17634 427 NE-GHPQPGGTEGNLVITDPWpgQTRTLFGDHERFEQTYFStfKGMYFSGDGARRDEDGYYWITGRSDDVINVAGHRLGT 505
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 510 AELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEE---TTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGK 586
Cdd:cd17634 506 AEIESVLVAHPKVAEAAVVGIPHAIKGQAPYAYVVLNHGVEpspELYAELRNWVRKEIGPLATPDVVHWVDSLPKTRSGK 585
|
.
gi 572879274 587 I 587
Cdd:cd17634 586 I 586
|
|
| PRK07768 |
PRK07768 |
long-chain-fatty-acid--CoA ligase; Validated |
243-513 |
1.55e-28 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 236091 [Multi-domain] Cd Length: 545 Bit Score: 120.10 E-value: 1.55e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 243 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQLRMILPNPLYHCLGSVAGTMMCLMYGATLILASPI 322
Cdd:PRK07768 153 DLALMQLTSGSTGSPKAVQITHGNLYANAEAMFVAAEF---DVETDVMVSWLPLFHDMGMVGFLTVPMYFGAELVKVTPM 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 323 -FNGKKAL--EAISRERGT------FLYgtpTMFVDIL-NQPDFSSYDISTMCGGVIAGSPAPPELIRAIIN-----KIN 387
Cdd:PRK07768 230 dFLRDPLLwaELISKYRGTmtaapnFAY---ALLARRLrRQAKPGAFDLSSLRFALNGAEPIDPADVEDLLDagarfGLR 306
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 388 MKDLVVAYGTTENS-PVTFAHFPE----DTV-------EQKAE-----------SVGRIMPHTEARIMNmEAGTLAKLNT 444
Cdd:PRK07768 307 PEAILPAYGMAEATlAVSFSPCGAglvvDEVdadllaaLRRAVpatkgntrrlaTLGPPLPGLEVRVVD-EDGQVLPPRG 385
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 572879274 445 PGELCIRGYCVMLGYWgEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELE 513
Cdd:PRK07768 386 VGVIELRGESVTPGYL-TMDGFIPAQDADGWLDTGDLGYLTEEGEVVVCGRVKDVIIMAGRNIYPTDIE 453
|
|
| A_NRPS_GliP_like |
cd17653 |
nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of ... |
76-594 |
4.58e-28 |
|
nonribosomal peptide synthase GliP-like; This family includes the adenylation (A) domain of nonribosomal peptide synthases (NRPS) gliotoxin biosynthesis protein P (GliP), thioclapurine biosynthesis protein P (tcpP) and Sirodesmin biosynthesis protein P (SirP). In the filamentous fungus Aspergillus fumigatus, NRPS GliP is involved in the biosynthesis of gliotoxin, which is initiated by the condensation of serine and phenylalanine. Studies show that GliP is not required for invasive aspergillosis, suggesting that the principal targets of gliotoxin are neutrophils or other phagocytes. SirP is a phytotoxin produced by the fungus Leptosphaeria maculans, which causes blackleg disease of canola (Brassica napus). In the fungus Claviceps purpurea, NRPS tcpP catalyzes condensation of tyrosine and glycine, part of biosynthesis of an unusual class of epipolythiodioxopiperazines (ETPs) that lacks the reactive thiol group for toxicity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341308 [Multi-domain] Cd Length: 433 Bit Score: 117.03 E-value: 4.58e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 76 QCLETTAQRVPEreALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLAtaqameleyVLK 155
Cdd:cd17653 1 DAFERIAAAHPD--AVAVESLGGSLTYGELDAASNALANRLLQLGVVPGDVVPLLSDRSLEMLVAILA---------ILK 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 156 kVGCkalvfpkqfktqqyynvlkqicpevenaqpgalksqrlpdltTVISVDAPLPGtlllDEVVAAgstrqhLDQLqyN 235
Cdd:cd17653 70 -AGA------------------------------------------AYVPLDAKLPS----ARIQAI------LRTS--G 94
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 236 QQFLSC----HDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQLRMILPNPLYH-CLGSVAGTmmcL 310
Cdd:cd17653 95 ATLLLTtdspDDLAYIIFTSGSTGIPKGVMVPHRGVLNYVSQPPARLDV---GPGSRVAQVLSIAFDaCIGEIFST---L 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 311 MYGATLILASPIFNgkkaLEAISRERgTFLYGTPTmFVDILNQPDFSSYDIStmcggVIAGSPAPPELI------RAIIN 384
Cdd:cd17653 169 CNGGTLVLADPSDP----FAHVARTV-DALMSTPS-ILSTLSPQDFPNLKTI-----FLGGEAVPPSLLdrwspgRRLYN 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 385 kinmkdlvvAYGTTENS-PVTFAHF-PEDTVeqkaeSVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGE 462
Cdd:cd17653 238 ---------AYGPTECTiSSTMTELlPGQPV-----TIGKPIPNSTCYILD-ADLQPVPEGVVGEICISGVQVARGYLGN 302
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 463 PQKTEEAVDQDKW------YWTGDVATMNEQGFCKIVGRSKDMI-IRG-----GENIYPAELEDffhthPKVQEVQVVGV 530
Cdd:cd17653 303 PALTASKFVPDPFwpgsrmYRTGDYGRWTEDGGLEFLGREDNQVkVRGfrinlEEIEEVVLQSQ-----PEVTQAAAIVV 377
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 572879274 531 KDdrmgeEICACIRlkdGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 594
Cdd:cd17653 378 NG-----RLVAFVT---PETVDVDGLRSELAKHLPSYAVPDRIIALDSFPLTANGKVDRKALRE 433
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
74-589 |
9.02e-28 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 119.68 E-value: 9.02e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 74 VGQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLAtaqameleyV 153
Cdd:PRK12316 513 VHRLFEEQVERTPEAPALA--FGEETLDYAELNRRANRLAHALIERGVGPDVLVGVAMERSIEMVVALLA---------I 581
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 154 LKKVGCKALVFPKQFKTQQYYnvlkqicpEVENAQPGALKSQR-------LPDLTTVISVDAPlpGTLLLDEVVAAGSTR 226
Cdd:PRK12316 582 LKAGGAYVPLDPEYPAERLAY--------MLEDSGVQLLLSQShlgrklpLAAGVQVLDLDRP--AAWLEGYSEENPGTE 651
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 227 QHLDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhektPEQLRMILPNPLYHCLgSVAGT 306
Cdd:PRK12316 652 LNPENLAY------------VIYTSGSTGKPKGAGNRHRALSNRLCWMQQAYGL----GVGDTVLQKTPFSFDV-SVWEF 714
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 307 MMCLMYGATLILASP--IFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCggVIAGSPAPPELIRAIIN 384
Cdd:PRK12316 715 FWPLMSGARLVVAAPgdHRDPAKLVELINREGVDTLHFVPSMLQAFLQDEDVASCTSLRRI--VCSGEALPADAQEQVFA 792
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 385 KINMKDLVVAYGTTENSpVTFAHFPedTVEQKAESV--GRIMPHTEARIMNMEAGTLAkLNTPGELCIRGYCVMLGYWGE 462
Cdd:PRK12316 793 KLPQAGLYNLYGPTEAA-IDVTHWT--CVEEGGDSVpiGRPIANLACYILDANLEPVP-VGVLGELYLAGRGLARGYHGR 868
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 463 PQKTEEA------VDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKddrmG 536
Cdd:PRK12316 869 PGLTAERfvpspfVAGERMYRTGDLARYRADGVIEYAGRIDHQVKLRGLRIELGEIEARLLEHPWVREAAVLAVD----G 944
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 572879274 537 EEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQK 589
Cdd:PRK12316 945 KQLVGYVVLESEGGDWREALKAHLAASLPEYMVPAQWLALERLPLTPNGKLDR 997
|
|
| PRK12467 |
PRK12467 |
peptide synthase; Provisional |
27-589 |
1.08e-26 |
|
peptide synthase; Provisional
Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 116.41 E-value: 1.08e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 27 LSRSWQEArLQGVRFLSSREVDRMV---STPIGGLSYVQGCTKKHLNSKTVGQCLETTAQRVPEREALVVlhEDVRLTFA 103
Cdd:PRK12467 465 LATHWRNL-LEAIVAEPRRRLGELPlldAEERARELVRWNAPATEYAPDCVHQLIEAQARQHPERPALVF--GEQVLSYA 541
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 104 QLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLAtaqameleyVLKKVGCKALVFPKQFKTQQYYnVLKQICPE 183
Cdd:PRK12467 542 ELNRQANRLAHVLIAAGVGPDVLVGIAVERSIEMVVGLLA---------VLKAGGAYVPLDPEYPQDRLAY-MLDDSGVR 611
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 184 VENAQPGALKSQRLPDLTTVISVDAPLPgtLLLDEVVAAGSTRQHLDQLQYnqqflschdpinIQFTSGTTGSPKGATLS 263
Cdd:PRK12467 612 LLLTQSHLLAQLPVPAGLRSLCLDEPAD--LLCGYSGHNPEVALDPDNLAY------------VIYTSGSTGQPKGVAIS 677
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 264 HYNIVNNSNILGERLKLhekTPEQlRMILPNPLYHCLGsvaGTMM--CLMYGATLILASP--IFNGKKALEAISRERGTF 339
Cdd:PRK12467 678 HGALANYVCVIAERLQL---AADD-SMLMVSTFAFDLG---VTELfgALASGATLHLLPPdcARDAEAFAALMADQGVTV 750
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 340 LYGTPTMFVDILN--QPDFSSYDISTMCGGVIagspAPPELIRAIINKINMKDLVVAYGTTENSpVTFAHFP--EDTVEQ 415
Cdd:PRK12467 751 LKIVPSHLQALLQasRVALPRPQRALVCGGEA----LQVDLLARVRALGPGARLINHYGPTETT-VGVSTYElsDEERDF 825
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 416 KAESVGRIMPHTEARIMNMEAGTLAkLNTPGELCIRGYCVMLGYWGEPQKTEE-------AVDQDKWYWTGDVATMNEQG 488
Cdd:PRK12467 826 GNVPIGQPLANLGLYILDHYLNPVP-VGVVGELYIGGAGLARGYHRRPALTAErfvpdpfGADGGRLYRTGDLARYRADG 904
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 489 FCKIVGRSKDMI-IRgGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEET----TVEEIKAFCKGK 563
Cdd:PRK12467 905 VIEYLGRMDHQVkIR-GFRIELGEIEARLLAQPGVREAVVLAQPGDAGLQLVAYLVPAAVADGAehqaTRDELKAQLRQV 983
|
570 580
....*....|....*....|....*.
gi 572879274 564 ISHFKIPKYIVFVTNYPLTISGKIQK 589
Cdd:PRK12467 984 LPDYMVPAHLLLLDSLPLTPNGKLDR 1009
|
|
| A_NRPS_PvdJ-like |
cd17649 |
non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal ... |
239-593 |
1.26e-26 |
|
non-ribosomal peptide synthetase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes pyoverdine biosynthesis protein PvdJ involved in the synthesis of pyoverdine, which consists of a chromophore group attached to a variable peptide chain and comprises around 6-12 amino acids that are specific for each Pseudomonas species, and for which the peptide might be first synthesized before the chromophore assembly. Also included is ornibactin biosynthesis protein OrbI; ornibactin is a tetrapeptide siderophore with an l-ornithine-d-hydroxyaspartate-l-serine-l-ornithine backbone. The adenylation domain at the N-terminal of OrbI possibly initiates the ornibactin with the binding of N5-hydroxyornithine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341304 [Multi-domain] Cd Length: 450 Bit Score: 113.23 E-value: 1.26e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 239 LSCHDPIN---IQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHektPEQlrMILPNPLYHCLGSVAGTMMCLMYGAT 315
Cdd:cd17649 88 LLTHHPRQlayVIYTSGSTGTPKGVAVSHGPLAAHCQATAERYGLT---PGD--RELQFASFNFDGAHEQLLPPLICGAC 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 316 LILAS-PIFNGKKAL-EAISRERGTFLYGTPT---MFVDILNQPDFSSYDISTMCggVIAGSPAPPELIRAIINKinMKD 390
Cdd:cd17649 163 VVLRPdELWASADELaEMVRELGVTVLDLPPAylqQLAEEADRTGDGRPPSLRLY--IFGGEALSPELLRRWLKA--PVR 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 391 LVVAYGTTENSPVTFAHFPEDTVEQKAESV--GRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEE 468
Cdd:cd17649 239 LFNAYGPTEATVTPLVWKCEAGAARAGASMpiGRPLGGRSAYILD-ADLNPVPVGVTGELYIGGEGLARGYLGRPELTAE 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 469 AVDQD-------KWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVkDDRMGEEICA 541
Cdd:cd17649 318 RFVPDpfgapgsRLYRTGDLARWRDDGVIEYLGRVDHQVKIRGFRIELGEIEAALLEHPGVREAAVVAL-DGAGGKQLVA 396
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 572879274 542 CIRLKDGEET--TVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 593
Cdd:cd17649 397 YVVLRAAAAQpeLRAQLRTALRASLPDYMVPAHLVFLARLPLTPNGKLDRKALP 450
|
|
| PrpE |
cd05967 |
Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or ... |
99-587 |
3.07e-26 |
|
Propionyl-CoA synthetase (PrpE); EC 6.2.1.17: propanoate:CoA ligase (AMP-forming) or propionate#CoA ligase (PrpE) catalyzes the first step of the 2-methylcitric acid cycle for propionate catabolism. It activates propionate to propionyl-CoA in a two-step reaction, which proceeds through a propionyl-AMP intermediate and requires ATP and Mg2+. In Salmonella enterica, the PrpE protein is required for growth of Salmonella enterica on propionate and can substitute for the acetyl-CoA synthetase (Acs) enzyme during growth on acetate. PrpE can also activate acetate, 3HP, and butyrate to their corresponding CoA-thioesters, although with less efficiency.
Pssm-ID: 341271 [Multi-domain] Cd Length: 617 Bit Score: 113.56 E-value: 3.07e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 99 RLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPnsyawvlMQLATAQAMeleyvlkkVGC------KALVFpKQFKTqq 172
Cdd:cd05967 82 TYTYAELLDEVSRLAGVLRKLGVVKGDRVIIYMP-------MIPEAAIAM--------LACarigaiHSVVF-GGFAA-- 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 173 yynvlKQICPEVENAQP--------GALKSQRLPDLTTV-----ISVDAPlPGTLLLDEVVAAGSTRQHLDQLQYNQQFL 239
Cdd:cd05967 144 -----KELASRIDDAKPklivtascGIEPGKVVPYKPLLdkaleLSGHKP-HHVLVLNRPQVPADLTKPGRDLDWSELLA 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 240 SC----------HDPINIQFTSGTTGSPKG--------ATLSHYNIvnnSNILGerlklhektpeqlrmILPNPLYHC-- 299
Cdd:cd05967 218 KAepvdcvpvaaTDPLYILYTSGTTGKPKGvvrdngghAVALNWSM---RNIYG---------------IKPGDVWWAas 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 300 -LGSVAG-TMMC---LMYGATLILaspiFNGKKA--------LEAISRERGTFLYGTPTMFVDILNQP----DFSSYDIS 362
Cdd:cd05967 280 dVGWVVGhSYIVygpLLHGATTVL----YEGKPVgtpdpgafWRVIEKYQVNALFTAPTAIRAIRKEDpdgkYIKKYDLS 355
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 363 TMCGGVIAGSPAPPELIRAIINKINmKDLVVAYGTTEN-SPVTFAHFPEDTVEQKAESVGRIMPHTEARIMNmEAGTLAK 441
Cdd:cd05967 356 SLRTLFLAGERLDPPTLEWAENTLG-VPVIDHWWQTETgWPITANPVGLEPLPIKAGSPGKPVPGYQVQVLD-EDGEPVG 433
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 442 LNTPGELCIRGYC---VMLGYWGEPQKTEEAV--DQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFF 516
Cdd:cd05967 434 PNELGNIVIKLPLppgCLLTLWKNDERFKKLYlsKFPGYYDTGDAGYKDEDGYLFIMGRTDDVINVAGHRLSTGEMEESV 513
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 572879274 517 HTHPKVQEVQVVGVKDDRMGEEICACIRLKDG----EETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:cd05967 514 LSHPAVAECAVVGVRDELKGQVPLGLVVLKEGvkitAEELEKELVALVREQIGPVAAFRLVIFVKRLPKTRSGKI 588
|
|
| ACS |
cd05966 |
Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); ... |
77-593 |
3.87e-26 |
|
Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Acetyl-CoA synthetase (ACS, EC 6.2.1.1, acetate#CoA ligase or acetate:CoA ligase (AMP-forming)) catalyzes the formation of acetyl-CoA from acetate, CoA, and ATP. Synthesis of acetyl-CoA is carried out in a two-step reaction. In the first step, the enzyme catalyzes the synthesis of acetyl-AMP intermediate from acetate and ATP. In the second step, acetyl-AMP reacts with CoA to produce acetyl-CoA. This enzyme is widely present in all living organisms. The activity of this enzyme is crucial for maintaining the required levels of acetyl-CoA, a key intermediate in many important biosynthetic and catabolic processes. Acetyl-CoA is used in the biosynthesis of glucose, fatty acids, and cholesterol. It can also be used in the production of energy in the citric acid cycle. Eukaryotes typically have two isoforms of acetyl-CoA synthetase, a cytosolic form involved in biosynthetic processes and a mitochondrial form primarily involved in energy generation.
Pssm-ID: 341270 [Multi-domain] Cd Length: 608 Bit Score: 113.04 E-value: 3.87e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 77 CLETTAQRVPEREALVVLHEDV----RLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQ------ 146
Cdd:cd05966 58 CLDRHLKERGDKVAIIWEGDEPdqsrTITYRELLREVCRFANVLKSLGVKKGDRVAIYMPMIPELVIAMLACARigavhs 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 147 -------AMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEvenaqpgALKsqRLPDLTTVISV-----DAPL-PG- 212
Cdd:cd05966 138 vvfagfsAESLADRINDAQCKLVITADGGYRGGKVIPLKEIVDE-------ALE--KCPSVEKVLVVkrtggEVPMtEGr 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 213 TLLLDEVVAagstrqhlDQLQYNQ-QFLSCHDPINIQFTSGTTGSPKG-----------ATLSHYNIVNnsnilgerlkl 280
Cdd:cd05966 209 DLWWHDLMA--------KQSPECEpEWMDSEDPLFILYTSGSTGKPKGvvhttggyllyAATTFKYVFD----------- 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 281 hektpeqlrmILPNPLYHC---LGSVAG-TMMC---LMYGATlilaSPIFNGKKAL-------EAISRERGTFLYGTPT- 345
Cdd:cd05966 270 ----------YHPDDIYWCtadIGWITGhSYIVygpLANGAT----TVMFEGTPTYpdpgrywDIVEKHKVTIFYTAPTa 335
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 346 --MFVDILNQPdFSSYDISTM--CGGViaGSPAPPELIRAIINKINMKDLVVA--YGTTENSPVTFAHFPEDTvEQKAES 419
Cdd:cd05966 336 irALMKFGDEW-VKKHDLSSLrvLGSV--GEPINPEAWMWYYEVIGKERCPIVdtWWQTETGGIMITPLPGAT-PLKPGS 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 420 VGRIMPHTEARIMNmEAGTLAKLNTPGELCIR----GycVMLGYWGEPQKTEEAVDQD--KWYWTGDVATMNEQGFCKIV 493
Cdd:cd05966 412 ATRPFFGIEPAILD-EEGNEVEGEVEGYLVIKrpwpG--MARTIYGDHERYEDTYFSKfpGYYFTGDGARRDEDGYYWIT 488
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 494 GRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVE---EIKAFCKGKISHFKIP 570
Cdd:cd05966 489 GRVDDVINVSGHRLGTAEVESALVAHPAVAEAAVVGRPHDIKGEAIYAFVTLKDGEEPSDElrkELRKHVRKEIGPIATP 568
|
570 580
....*....|....*....|...
gi 572879274 571 KYIVFVTNYPLTISGKIQKFKLR 593
Cdd:cd05966 569 DKIQFVPGLPKTRSGKIMRRILR 591
|
|
| AACS_like |
cd05968 |
Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This ... |
56-593 |
5.73e-26 |
|
Uncharacterized acyl-CoA synthetase subfamily similar to Acetoacetyl-CoA synthetase; This uncharacterized acyl-CoA synthetase family (EC 6.2.1.16, or acetoacetate#CoA ligase or acetoacetate:CoA ligase (AMP-forming)) is highly homologous to acetoacetyl-CoA synthetase. However, the proteins in this family exist in only bacteria and archaea. AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms.
Pssm-ID: 341272 [Multi-domain] Cd Length: 610 Bit Score: 112.58 E-value: 5.73e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 56 GGLSYVQGCTKKHLNskTVGQCLETTAQRVPEREALVVLHED--VR-LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGP 132
Cdd:cd05968 47 GGKPWAAWFVGGRMN--IVEQLLDKWLADTRTRPALRWEGEDgtSRtLTYGELLYEVKRLANGLRALGVGKGDRVGIYLP 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 133 NSYAWVLMQLATAQA-MELEYVLKKVGCKALVFPKQ-------FKTQQYYNVLKQICPEvENAQPGALKSQRLPDLTTVI 204
Cdd:cd05968 125 MIPEIVPAFLAVARIgGIVVPIFSGFGKEAAATRLQdaeakalITADGFTRRGREVNLK-EEADKACAQCPTVEKVVVVR 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 205 SVDAPLPGT----LLLDEVVAA---GSTRQHLDqlqynqqflschDPINIQFTSGTTGSPKGATLSHynivnnsniLGER 277
Cdd:cd05968 204 HLGNDFTPAkgrdLSYDEEKETagdGAERTESE------------DPLMIIYTSGTTGKPKGTVHVH---------AGFP 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 278 LKLHEKtpeqlrmilpnpLYHCLG----------SVAGTMM-------CLMYGATLIL--ASPIFNGKKAL-EAISRERG 337
Cdd:cd05968 263 LKAAQD------------MYFQFDlkpgdlltwfTDLGWMMgpwlifgGLILGATMVLydGAPDHPKADRLwRMVEDHEI 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 338 TFLYGTPTMF-------VDILNQPDFSSYDI--STmcggviaGSPAPPELIRAIINKINMKDL-VVAY-GTTENSPVTFA 406
Cdd:cd05968 331 THLGLSPTLIralkprgDAPVNAHDLSSLRVlgST-------GEPWNPEPWNWLFETVGKGRNpIINYsGGTEISGGILG 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 407 HFPEDTVeqKAESVGRIMPHTEARIMNmEAGTLAKlNTPGELCIRGYCVML--GYWGEPQKTEEAvdqdkwYWT------ 478
Cdd:cd05968 404 NVLIKPI--KPSSFNGPVPGMKADVLD-ESGKPAR-PEVGELVLLAPWPGMtrGFWRDEDRYLET------YWSrfdnvw 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 479 --GDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETT---V 553
Cdd:cd05968 474 vhGDFAYYDEEGYFYILGRSDDTINVAGKRVGPAEIESVLNAHPAVLESAAIGVPHPVKGEAIVCFVVLKPGVTPTealA 553
|
570 580 590 600
....*....|....*....|....*....|....*....|
gi 572879274 554 EEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 593
Cdd:cd05968 554 EELMERVADELGKPLSPERILFVKDLPKTRNAKVMRRVIR 593
|
|
| LC_FACS_bac |
cd05932 |
Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter ... |
98-529 |
9.80e-26 |
|
Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase. Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase in this family is involved in the synthesis of isoprenoid wax ester storage compounds when grown on phytol as the sole carbon source. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341255 [Multi-domain] Cd Length: 508 Bit Score: 111.02 E-value: 9.80e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 98 VRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLA-------------TAQAMELEYVLKKVGCKALVF 164
Cdd:cd05932 5 VEFTWGEVADKARRLAAALRALGLEPGSKIALISKNCAEWFITDLAiwmaghisvplypTLNPDTIRYVLEHSESKALFV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 165 PKqfktqqyynvlkqiCPEVENAQPGalksqrLPDltTVISVDAPLPGTLLLDEvvaagstrqHLDQLQYNQQFL---SC 241
Cdd:cd05932 85 GK--------------LDDWKAMAPG------VPE--GLISISLPPPSAANCQY---------QWDDLIAQHPPLeerPT 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 242 HDP---INIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKlhekTPEQLRMILPNPLYHCLGSVAGTMMCLMYGATLIL 318
Cdd:cd05932 134 RFPeqlATLIYTSGTTGQPKGVMLTFGSFAWAAQAGIEHIG----TEENDRMLSYLPLAHVTERVFVEGGSLYGGVLVAF 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 319 ASPIfngKKALEAISRERGTFLYGTPTMFVD----------------ILNQPDFSSYDISTMCGGV------IAGS---P 373
Cdd:cd05932 210 AESL---DTFVEDVQRARPTLFFSVPRLWTKfqqgvqdkipqqklnlLLKIPVVNSLVKRKVLKGLgldqcrLAGCgsaP 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 374 APPELIrAIINKINMkDLVVAYGTTENSPVTFAHFPEDtveQKAESVGRIMPHTEARImnmeagtlaklNTPGELCIRGY 453
Cdd:cd05932 287 VPPALL-EWYRSLGL-NILEAYGMTENFAYSHLNYPGR---DKIGTVGNAGPGVEVRI-----------SEDGEILVRSP 350
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 572879274 454 CVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRGGENIYPAELEDFFHTHPKVQEVQVVG 529
Cdd:cd05932 351 ALMMGYYKDPEATAEAFTADGFLRTGDKGELDADGNLTITGRVKDIFkTSKGKYVAPAPIENKLAEHDRVEMVCVIG 427
|
|
| entE |
PRK10946 |
(2,3-dihydroxybenzoyl)adenylate synthase; |
410-600 |
2.17e-25 |
|
(2,3-dihydroxybenzoyl)adenylate synthase;
Pssm-ID: 236803 [Multi-domain] Cd Length: 536 Bit Score: 110.46 E-value: 2.17e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 410 EDTVEQKAESVGRIM-PHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQG 488
Cdd:PRK10946 345 DDSDERIFTTQGRPMsPDDEVWVAD-ADGNPLPQGEVGRLMTRGPYTFRGYYKSPQHNASAFDANGFYCSGDLVSIDPDG 423
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 489 FCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVeeIKAFCKGK-ISHF 567
Cdd:PRK10946 424 YITVVGREKDQINRGGEKIAAEEIENLLLRHPAVIHAALVSMEDELMGEKSCAFLVVKEPLKAVQ--LRRFLREQgIAEF 501
|
170 180 190
....*....|....*....|....*....|...
gi 572879274 568 KIPKYIVFVTNYPLTISGKIQKFKLREQMERHL 600
Cdd:PRK10946 502 KLPDRVECVDSLPLTAVGKVDKKQLRQWLASRA 534
|
|
| A_NRPS_MycA_like |
cd05908 |
The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin ... |
247-597 |
2.19e-25 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as (amino)-acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family includes NRPS similar to mycosubtilin synthase subunit A (MycA). Mycosubtilin, which is characterized by a beta-amino fatty acid moiety linked to the circular heptapeptide Asn-Tyr-Asn-Gln-Pro-Ser-Asn, belongs to the iturin family of lipopeptide antibiotics. The mycosubtilin synthase subunit A (MycA) combines functional domains derived from peptide synthetases, amino transferases, and fatty acid synthases. Nonribosomal peptide synthetases are large multifunction enzymes that synthesize many therapeutically useful peptides. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and, in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341234 [Multi-domain] Cd Length: 499 Bit Score: 109.89 E-value: 2.19e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 247 IQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCLGSVAGTMMCLMYGA-------TLILA 319
Cdd:cd05908 111 IQFSSGSTGDPKGVMLTHENLVHNMFAILNSTEWKTKD----RILSWMPLTHDMGLIAFHLAPLIAGMnqylmptRLFIR 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 320 SPIFNGKKALE--AISRERGTFLYgtpTMFVDILNQPDFSSYDISTMcGGVIAGS-PAPPELIRAIIN---KINMKD--L 391
Cdd:cd05908 187 RPILWLKKASEhkATIVSSPNFGY---KYFLKTLKPEKANDWDLSSI-RMILNGAePIDYELCHEFLDhmsKYGLKRnaI 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 392 VVAYGTTENS-------------PVTFAH------FPEDTVEQKAE------SVGRIMPHTEARIMNMEAGTLAKlNTPG 446
Cdd:cd05908 263 LPVYGLAEASvgaslpkaqspfkTITLGRrhvthgEPEPEVDKKDSecltfvEVGKPIDETDIRICDEDNKILPD-GYIG 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 447 ELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEqGFCKIVGRSKDMIIRGGENIYPAELEDFfhthpkvqEVQ 526
Cdd:cd05908 342 HIQIRGKNVTPGYYNNPEATAKVFTDDGWLKTGDLGFIRN-GRLVITGREKDIIFVNGQNVYPHDIERI--------AEE 412
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 527 VVGVKDDRMGeeICACirlkDGEETTVEEIKAFC--KGKISHF-----KIPKY-----------IVFVTNYPLTISGKIQ 588
Cdd:cd05908 413 LEGVELGRVV--ACGV----NNSNTRNEEIFCFIehRKSEDDFyplgkKIKKHlnkrggwqineVLPIRRIPKTTSGKVK 486
|
....*....
gi 572879274 589 KFKLREQME 597
Cdd:cd05908 487 RYELAQRYQ 495
|
|
| PRK13388 |
PRK13388 |
acyl-CoA synthetase; Provisional |
243-595 |
3.40e-25 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 237374 [Multi-domain] Cd Length: 540 Bit Score: 109.73 E-value: 3.40e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 243 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMilpnPLYHCLGSVAGTMMCLMYGATLILaSPI 322
Cdd:PRK13388 151 DPFMLIFTSGTTGAPKAVRCSHGRLAFAGRALTERFGLTRDDVCYVSM----PLFHSNAVMAGWAPAVASGAAVAL-PAK 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 323 FNGKKALEAISRERGTFL-Y-GTPTMFvdILNQPDFSSYDISTMCGGViaGSPAPPELIRAIINKINMKdLVVAYGTTEN 400
Cdd:PRK13388 226 FSASGFLDDVRRYGATYFnYvGKPLAY--ILATPERPDDADNPLRVAF--GNEASPRDIAEFSRRFGCQ-VEDGYGSSEG 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 401 SPVTFAH--FPEDTVEQKAESVGRIMPHTE---ARIMNMEAGTLAKLNTP-GELC-IRGYCVMLGYWGEPQKTEEAVdQD 473
Cdd:PRK13388 301 AVIVVREpgTPPGSIGRGAPGVAIYNPETLtecAVARFDAHGALLNADEAiGELVnTAGAGFFEGYYNNPEATAERM-RH 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 474 KWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTV 553
Cdd:PRK13388 380 GMYWSGDLAYRDADGWIYFAGRTADWMRVDGENLSAAPIERILLRHPAINRVAVYAVPDERVGDQVMAALVLRDGATFDP 459
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 572879274 554 EEIKAFCKGK--ISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:PRK13388 460 DAFAAFLAAQpdLGTKAWPRYVRIAADLPSTATNKVLKRELIAQ 503
|
|
| PRK05857 |
PRK05857 |
fatty acid--CoA ligase; |
68-592 |
6.76e-25 |
|
fatty acid--CoA ligase;
Pssm-ID: 180293 [Multi-domain] Cd Length: 540 Bit Score: 108.94 E-value: 6.76e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 68 HLNSKTVGQCLETtAQRVPEREALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDR---LGMWGPNSYawvLMQLAT 144
Cdd:PRK05857 11 QLPSTVLDRVFEQ-ARQQPEAIALRRCDGTSALRYRELVAEVGGLAADLRAQSVSRGSRvlvISDNGPETY---LSVLAC 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 145 AqameleyvlkKVGCKALVFPKQFKTQQYyNVLKQIC--PEVENAQPGALKSQRLPDLTTVISvdaplpgTLLLDEVVAA 222
Cdd:PRK05857 87 A----------KLGAIAVMADGNLPIAAI-ERFCQITdpAAALVAPGSKMASSAVPEALHSIP-------VIAVDIAAVT 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 223 GSTRQHLDQLQYNQQF-LSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGErlklhektpEQLRMI---------L 292
Cdd:PRK05857 149 RESEHSLDAASLAGNAdQGSEDPLAMIFTSGTTGEPKAVLLANRTFFAVPDILQK---------EGLNWVtwvvgettyS 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 293 PNPLYHcLGSVAGTMMCLMYGATLILASPifNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGS 372
Cdd:PRK05857 220 PLPATH-IGGLWWILTCLMHGGLCVTGGE--NTTSLLEILTTNAVATTCLVPTLLSKLVSELKSANATVPSLRLVGYGGS 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 373 PAppelIRAIINKINMKDLVVA--YGTTENSpVTFAHFPEDT-----VEQKAesVGRIMPHTEARIMNMEAG-----TLA 440
Cdd:PRK05857 297 RA----IAADVRFIEATGVRTAqvYGLSETG-CTALCLPTDDgsivkIEAGA--VGRPYPGVDVYLAATDGIgptapGAG 369
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 441 KLNTPGELCIRGYCVMLGYWGEPQKTEEaVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHP 520
Cdd:PRK05857 370 PSASFGTLWIKSPANMLGYWNNPERTAE-VLIDGWVNTGDLLERREDGFFYIKGRSSEMIICGGVNIAPDEVDRIAEGVS 448
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 572879274 521 KVQEVQVVGVKDDRMGEEI-CACIRLKDGEETTVEEIK----AFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKL 592
Cdd:PRK05857 449 GVREAACYEIPDEEFGALVgLAVVASAELDESAARALKhtiaARFRRESEPMARPSTIVIVTDIPRTQSGKVMRASL 525
|
|
| LC_FACS_euk1 |
cd17639 |
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The ... |
247-529 |
1.38e-24 |
|
Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins; The members of this family are eukaryotic fatty acid CoA synthetases (EC 6.2.1.3) that activate fatty acids with chain lengths of 12 to 20 and includes fungal proteins. They act on a wide range of long-chain saturated and unsaturated fatty acids, but the enzymes from different tissues show some variation in specificity. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions. Organisms tend to have multiple isoforms of LC-FACS genes with multiple splice variants. For example, nine genes are found in Arabidopsis and six genes are expressed in mammalian cells. In Schizosaccharomyces pombe, lcf1 gene encodes a new fatty acyl-CoA synthetase that preferentially recognizes myristic acid as a substrate.
Pssm-ID: 341294 [Multi-domain] Cd Length: 507 Bit Score: 107.69 E-value: 1.38e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 247 IQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMILPnpLYHCLgSVAGTMMCLMYGATLILASP----- 321
Cdd:cd17639 93 IMYTSGSTGNPKGVMLTHGNLVAGIAGLGDRVPELLGPDDRYLAYLP--LAHIF-ELAAENVCLYRGGTIGYGSPrtltd 169
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 322 ----------------IFNG--------KKALEAISRERGTF------------------LYGTPtmfvdILNQPDFSSy 359
Cdd:cd17639 170 kskrgckgdltefkptLMVGvpaiwdtiRKGVLAKLNPMGGLkrtlfwtayqsklkalkeGPGTP-----LLDELVFKK- 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 360 dISTMCGGVIA-----GSPAPPELIRAIinKINMKDLVVAYGTTENSPVTFAHFPEDtveQKAESVGRIMPHTEARIMNM 434
Cdd:cd17639 244 -VRAALGGRLRymlsgGAPLSADTQEFL--NIVLCPVIQGYGLTETCAGGTVQDPGD---LETGRVGPPLPCCEIKLVDW 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 435 -EAGTLAKLNTP-GELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRGGENIYPAE 511
Cdd:cd17639 318 eEGGYSTDKPPPrGEILIRGPNVFKGYYKNPEKTKEAFDGDGWFHTGDIGEFHPDGTLKIIDRKKDLVkLQNGEYIALEK 397
|
330
....*....|....*...
gi 572879274 512 LEDFFHTHPKVQEVQVVG 529
Cdd:cd17639 398 LESIYRSNPLVNNICVYA 415
|
|
| A_NRPS_LgrA-like |
cd17645 |
adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This ... |
76-592 |
2.94e-24 |
|
adenylation (A) domain of linear gramicidin synthetase (LgrA) and similar proteins; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes linear gramicidin synthetase (LgrA) in Brevibacillus brevis. LgrA has a formylation domain fused to the N-terminal end that formylates its substrate for linear gramicidin synthesis to proceed. This formyl group is essential for the clinically important antibacterial activity of gramicidin by enabling head-to-head gramicidin dimers to make a beta-helical pore in gram-positive bacterial membranes, allowing free passage of monovalent cations, destroying the ion gradient and killing bacteria. This family also includes bacitracin synthetase 1 (known as ATP-dependent cysteine adenylase or BA1); it activates cysteine, incorporates two D-amino acids, releases and cyclizes the mature bacitracin, an antibiotic that is a mixture of related cyclic peptides that disrupt gram positive bacteria by interfering with cell wall and peptidoglycan synthesis. Also included is surfactin synthetase which activates and polymerizes the amino acids Leu, Glu, Asp, and Val to form the antibiotic surfactin.
Pssm-ID: 341300 [Multi-domain] Cd Length: 440 Bit Score: 105.71 E-value: 2.94e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 76 QCLETTAQRVPEREAlvVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGmwgpnsyawVLMQLATAQAMELEYVLK 155
Cdd:cd17645 2 QLFEEQVERTPDHVA--VVDRGQSLTYKQLNEKANQLARHLRGKGVKPDDQVG---------IMLDKSLDMIAAILGVLK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 156 KVGckALVfpkqfktqqyynvlkQICPEVenaqPGALKSQRLPDLTTVISVDAPlpgtllldevvaagstrqhlDQLQYn 235
Cdd:cd17645 71 AGG--AYV---------------PIDPDY----PGERIAYMLADSSAKILLTNP--------------------DDLAY- 108
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 236 qqflschdpinIQFTSGTTGSPKGATLSHYNIVNnsnILGERLKLHEKTPEQLRMILPNPLYHclGSVAGTMMCLMYGAT 315
Cdd:cd17645 109 -----------VIYTSGSTGLPKGVMIEHHNLVN---LCEWHRPYFGVTPADKSLVYASFSFD--ASAWEIFPHLTAGAA 172
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 316 L-ILASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDIstmcggVIAGSPappeliraIINKINMK--DLV 392
Cdd:cd17645 173 LhVVPSERRLDLDALNDYFNQEGITISFLPTGAAEQFMQLDNQSLRV------LLTGGD--------KLKKIERKgyKLV 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 393 VAYGTTENSpVTFAHFPEDTVEQKAeSVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEA--- 469
Cdd:cd17645 239 NNYGPTENT-VVATSFEIDKPYANI-PIGKPIDNTRVYILD-EALQLQPIGVAGELCIAGEGLARGYLNRPELTAEKfiv 315
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 470 ---VDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLK 546
Cdd:cd17645 316 hpfVPGERMYRTGDLAKFLPDGNIEFLGRLDQQVKIRGYRIEPGEIEPFLMNHPLIELAAVLAKEDADGRKYLVAYVTAP 395
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 572879274 547 dgEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKL 592
Cdd:cd17645 396 --EEIPHEELREWLKNDLPDYMIPTYFVHLKALPLTANGKVDRKAL 439
|
|
| A_NRPS_ACVS-like |
cd17648 |
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV ... |
247-587 |
3.26e-24 |
|
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase; This family contains ACV synthetase (ACVS, EC 6.3.2.26; also known as N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase or delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase) is involved in medically important antibiotic biosynthesis. ACV synthetase is active in an early step in the penicillin G biosynthesis pathway which involves the formation of the tripeptide 6-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine (ACV); each of the constituent amino acids of the tripeptide ACV are activated as aminoacyl-adenylates with peptide bonds formed through the participation of amino acid thioester intermediates. ACV is then cyclized by the action of isopenicillin N synthase.
Pssm-ID: 341303 [Multi-domain] Cd Length: 453 Bit Score: 105.95 E-value: 3.26e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 247 IQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLrMILPNplYHCLGSVAGTMMCLMYGATLILASPIFNGK 326
Cdd:cd17648 99 AIYTSGTTGKPKGVLVEHGSVVNLRTSLSERYFGRDNGDEAV-LFFSN--YVFDFFVEQMTLALLNGQKLVVPPDEMRFD 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 327 KA--LEAISRERGTFLYGTPTmfvdILNQPDFSSYDISTMcggVIAgspAPPELIRAIINKI--NMKDLVV-AYGTTENS 401
Cdd:cd17648 176 PDrfYAYINREKVTYLSGTPS----VLQQYDLARLPHLKR---VDA---AGEEFTAPVFEKLrsRFAGLIInAYGPTETT 245
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 402 pVTFAHFPEDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEE-------AVDQDK 474
Cdd:cd17648 246 -VTNHKRFFPGDQRFDKSLGRPVRNTKCYVLN-DAMKRVPVGAVGELYLGGDGVARGYLNRPELTAErflpnpfQTEQER 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 475 W-------YWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICA----CI 543
Cdd:cd17648 324 ArgrnarlYKTGDLVRWLPSGELEYLGRNDFQVKIRGQRIEPGEVEAALASYPGVRECAVVAKEDASQAQSRIQkylvGY 403
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 572879274 544 RLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:cd17648 404 YLPEPGHVPESDLLSFLRAKLPRYMVPARLVRLEGIPVTINGKL 447
|
|
| MACS_like_1 |
cd05974 |
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the ... |
100-594 |
3.89e-24 |
|
Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); MACS catalyzes the two-step activation of medium chain fatty acids (containing 4-12 carbons). The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. MACS enzymes are localized to mitochondria.
Pssm-ID: 341278 [Multi-domain] Cd Length: 432 Bit Score: 105.34 E-value: 3.89e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 100 LTFAQLKEEVDKAASGLLSIGLCKGDR-LGMWGPNSYAWVLMqLAtaqAMELeyvlkkvgcKALVFPKqfktqqyynvlk 178
Cdd:cd05974 1 VSFAEMSARSSRVANFLRSIGVGRGDRiLLMLGNVVELWEAM-LA---AMKL---------GAVVIPA------------ 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 179 qicpevenaqpgalksqrlpdlTTVISVDAplpgtlLLDEVVAAGSTRQHLDQLQYnqqflsCHDPINIQFTSGTTGSPK 258
Cdd:cd05974 56 ----------------------TTLLTPDD------LRDRVDRGGAVYAAVDENTH------ADDPMLLYFTSGTTSKPK 101
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 259 GATLSH--YNIVNNSNILGERLKlhektPEQLRMILPNPlyhclGSVAGTMMCLM----YGATLILAS-PIFNGKKALEA 331
Cdd:cd05974 102 LVEHTHrsYPVGHLSTMYWIGLK-----PGDVHWNISSP-----GWAKHAWSCFFapwnAGATVFLFNyARFDAKRVLAA 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 332 ISRERGTFLYGTPTMFvDILNQPDFSSYDIS--TMCGgviAGSPAPPELIRAIINK--INMKDlvvAYGTTENSpVTFAH 407
Cdd:cd05974 172 LVRYGVTTLCAPPTVW-RMLIQQDLASFDVKlrEVVG---AGEPLNPEVIEQVRRAwgLTIRD---GYGQTETT-ALVGN 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 408 FPEDTVeqKAESVGRIMPHTEARIMNMEAGTLAKlntpGELCI-----RGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVA 482
Cdd:cd05974 244 SPGQPV--KAGSMGRPLPGYRVALLDPDGAPATE----GEVALdlgdtRPVGLMKGYAGDPDKTAHAM-RGGYYRTGDIA 316
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 483 TMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVE---EIKAF 559
Cdd:cd05974 317 MRDEDGYLTYVGRADDVFKSSDYRISPFELESVLIEHPAVAEAAVVPSPDPVRLSVPKAFIVLRAGYEPSPEtalEIFRF 396
|
490 500 510
....*....|....*....|....*....|....*
gi 572879274 560 CKGKISHFKIPKYIVFVtNYPLTISGKIQKFKLRE 594
Cdd:cd05974 397 SRERLAPYKRIRRLEFA-ELPKTISGKIRRVELRR 430
|
|
| PRK04813 |
PRK04813 |
D-alanine--poly(phosphoribitol) ligase subunit DltA; |
78-587 |
1.27e-23 |
|
D-alanine--poly(phosphoribitol) ligase subunit DltA;
Pssm-ID: 235313 [Multi-domain] Cd Length: 503 Bit Score: 104.59 E-value: 1.27e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVVLHEdvRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYawvLMqLATAQAmeleyvLKKV 157
Cdd:PRK04813 8 IEEFAQTQPDFPAYDYLGE--KLTYGQLKEDSDALAAFIDSLKLPDKSPIIVFGHMSP---EM-LATFLG------AVKA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 158 GCKalvfpkqfktqqYYNVLKQICPE-----VENAQPGALKSqrlPDLTTVISVDAPlpgTLLLDEVVAAGSTRQHLDQl 232
Cdd:PRK04813 76 GHA------------YIPVDVSSPAEriemiIEVAKPSLIIA---TEELPLEILGIP---VITLDELKDIFATGNPYDF- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 233 qynQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILgerLKLHEkTPEQLRMiLPNPLYHCLGSVAGTMMCLMY 312
Cdd:PRK04813 137 ---DHAVKGDDNYYIIFTSGTTGKPKGVQISHDNLVSFTNWM---LEDFA-LPEGPQF-LNQAPYSFDLSVMDLYPTLAS 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 313 GATLILASP--IFNGKKALEAISRERGTFLYGTPTmFVDI-LNQPDFSSYDISTM-----CGGVIAGSPAPPELIR---- 380
Cdd:PRK04813 209 GGTLVALPKdmTANFKQLFETLPQLPINVWVSTPS-FADMcLLDPSFNEEHLPNLthflfCGEELPHKTAKKLLERfpsa 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 381 AIINkinmkdlvvAYGTTENS-PVTFAHFPEDTVEQKAE-SVGRIMPHTEARIMnMEAGTLAKLNTPGELCIRGYCVMLG 458
Cdd:PRK04813 288 TIYN---------TYGPTEATvAVTSIEITDEMLDQYKRlPIGYAKPDSPLLII-DEEGTKLPDGEQGEIVISGPSVSKG 357
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 459 YWGEPQKTEEA---VDQDKWYWTGDVATM-NEQGFCKivGRSkDMIIRggENIYPAELEDFFHTHPKVQEVQ---VVGVK 531
Cdd:PRK04813 358 YLNNPEKTAEAfftFDGQPAYHTGDAGYLeDGLLFYQ--GRI-DFQIK--LNGYRIELEEIEQNLRQSSYVEsavVVPYN 432
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 532 DDRMGEEICACIRLKDG----EETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:PRK04813 433 KDHKVQYLIAYVVPKEEdferEFELTKAIKKELKERLMEYMIPRKFIYRDSLPLTPNGKI 492
|
|
| A_NRPS_SidN3_like |
cd05918 |
The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); ... |
242-598 |
5.14e-23 |
|
The adenylation (A) domain of siderophore-synthesizing nonribosomal peptide synthetases (NRPS); The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. This family of siderophore-synthesizing NRPS includes the third adenylation domain of SidN from the endophytic fungus Neotyphodium lolii, ferrichrome siderophore synthetase, HC-toxin synthetase, and enniatin synthase. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341242 [Multi-domain] Cd Length: 481 Bit Score: 102.62 E-value: 5.14e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 242 HDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMilpnpL----YHCLGSVAGTMMCLMYGATLI 317
Cdd:cd05918 106 SDAAYVIFTSGSTGKPKGVVIEHRALSTSALAHGRALGLTSES----RV-----LqfasYTFDVSILEIFTTLAAGGCLC 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 318 LASpifngKKAL-----EAISRERGTFLYGTPTmFVDILNQPDFSSydISTMcggVIAGSPAPPELIRAIINKINmkdLV 392
Cdd:cd05918 177 IPS-----EEDRlndlaGFINRLRVTWAFLTPS-VARLLDPEDVPS--LRTL---VLGGEALTQSDVDTWADRVR---LI 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 393 VAYGTTENSPvtFAHFPEDTVEQKAESVGRIMPhteARI-----MNMEAgtLAKLNTPGELCIRGYCVMLGYWGEPQKTE 467
Cdd:cd05918 243 NAYGPAECTI--AATVSPVVPSTDPRNIGRPLG---ATCwvvdpDNHDR--LVPIGAVGELLIEGPILARGYLNDPEKTA 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 468 EA-VDQDKW------------YWTGDVATMNEQGFCKIVGRSKDMI-IRgGENIYPAELEDFFHTHPKVQEVQVVGV--- 530
Cdd:cd05918 316 AAfIEDPAWlkqegsgrgrrlYRTGDLVRYNPDGSLEYVGRKDTQVkIR-GQRVELGEIEHHLRQSLPGAKEVVVEVvkp 394
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 531 KDDRMGEEICACIRLKDGEETT-----------------VEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLR 593
Cdd:cd05918 395 KDGSSSPQLVAFVVLDGSSSGSgdgdslflepsdefralVAELRSKLRQRLPSYMVPSVFLPLSHLPLTASGKIDRRALR 474
|
....*
gi 572879274 594 EQMER 598
Cdd:cd05918 475 ELAES 479
|
|
| PRK12467 |
PRK12467 |
peptide synthase; Provisional |
72-589 |
1.60e-22 |
|
peptide synthase; Provisional
Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 103.32 E-value: 1.60e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 72 KTVGQCLETTAQRVPEREALVVlhEDVRLTFAQLKEEVDKAASGLLSIGLckgdrlgmwGPNsyawVLMQLATAQAME-- 149
Cdd:PRK12467 3095 RLVHQLIEAQVARTPEAPALVF--GDQQLSYAELNRRANRLAHRLIAIGV---------GPD----VLVGVAVERSVEmi 3159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 150 --LEYVLKKVGCKALVFPKQFKTQQYYNVlkqicpevENAQPGALKSQ-----RLPDLTTVIsvdaplpgTLLLDEVVAA 222
Cdd:PRK12467 3160 vaLLAVLKAGGAYVPLDPEYPRERLAYMI--------EDSGVKLLLTQahlleQLPAPAGDT--------ALTLDRLDLN 3223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 223 G------STRQHLDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMIlpnpl 296
Cdd:PRK12467 3224 GysennpSTRVMGENLAY------------VIYTSGSTGKPKGVGVRHGALANHLCWIAEAYELDANDRVLLFMS----- 3286
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 297 YHCLGSVAGTMMCLMYGATLILA-SPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSY-DISTMCGGviaGSPA 374
Cdd:PRK12467 3287 FSFDGAQERFLWTLICGGCLVVRdNDLWDPEELWQAIHAHRISIACFPPAYLQQFAEDAGGADCaSLDIYVFG---GEAV 3363
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 375 PPELIRAIINKINMKDLVVAYGTTEnSPVTFAHF--PEDTV-EQKAESVGRIMPHTEARIMNMEAGTLAkLNTPGELCIR 451
Cdd:PRK12467 3364 PPAAFEQVKRKLKPRGLTNGYGPTE-AVVTVTLWkcGGDAVcEAPYAPIGRPVAGRSIYVLDGQLNPVP-VGVAGELYIG 3441
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 452 GYCVMLGYWGEPQKTEEAVDQD-------KWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQE 524
Cdd:PRK12467 3442 GVGLARGYHQRPSLTAERFVADpfsgsggRLYRTGDLARYRADGVIEYLGRIDHQVKIRGFRIELGEIEARLLQHPSVRE 3521
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 572879274 525 VQVVGVkDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQK 589
Cdd:PRK12467 3522 AVVLAR-DGAGGKQLVAYVVPADPQGDWRETLRDHLAASLPDYMVPAQLLVLAAMPLGPNGKVDR 3585
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
27-589 |
1.93e-22 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 103.11 E-value: 1.93e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 27 LSRSWQEARLQGVRFLSSREVDRMVSTPIGGLSYVQG---CTKKHLNSKTVGQCLETTAQRVPEREALVVlhEDVRLTFA 103
Cdd:PRK12316 3009 LARHWQNLLRGMVENPQRSVDELAMLDAEERGQLLEAwnaTAAEYPLERGVHRLFEEQVERTPDAVALAF--GEQRLSYA 3086
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 104 QLKEEVDKAASGLLSIGLckgdrlgmwGPNSYAWVLMQLATAQAMELEYVLKKVGCKALVFPKQFKTQQYYnvlkqicpE 183
Cdd:PRK12316 3087 ELNRRANRLAHRLIERGV---------GPDVLVGVAVERSLEMVVGLLAILKAGGAYVPLDPEYPEERLAY--------M 3149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 184 VENAQPGALKSQ---RLPDLTTVISVDAPLPGTLLLDEVVAAGSTRQHLDQLQYnqqflschdpiniqfTSGTTGSPKGA 260
Cdd:PRK12316 3150 LEDSGAQLLLSQshlRLPLAQGVQVLDLDRGDENYAEANPAIRTMPENLAYVIY---------------TSGSTGKPKGV 3214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 261 TLSHYNIVNNSNILGERLKLHEKTpeqlrMILPNPLYHCLGSVAGTMMCLMYGATLILASP--IFNGKKALEAISRERGT 338
Cdd:PRK12316 3215 GIRHSALSNHLCWMQQAYGLGVGD-----RVLQFTTFSFDVFVEELFWPLMSGARVVLAGPedWRDPALLVELINSEGVD 3289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 339 FLYGTPTMFVDILNQPDFSSYDISTMCggVIAGSPAPPELIRAIINKInmkDLVVAYGTTEnSPVTFAHFPEDTVEQKAE 418
Cdd:PRK12316 3290 VLHAYPSMLQAFLEEEDAHRCTSLKRI--VCGGEALPADLQQQVFAGL---PLYNLYGPTE-ATITVTHWQCVEEGKDAV 3363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 419 SVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQD------KWYWTGDVATMNEQGFCKI 492
Cdd:PRK12316 3364 PIGRPIANRACYILD-GSLEPVPVGALGELYLGGEGLARGYHNRPGLTAERFVPDpfvpgeRLYRTGDLARYRADGVIEY 3442
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 493 VGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKddrmGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKY 572
Cdd:PRK12316 3443 IGRVDHQVKIRGFRIELGEIEARLLEHPWVREAVVLAVD----GRQLVAYVVPEDEAGDLREALKAHLKASLPEYMVPAH 3518
|
570
....*....|....*..
gi 572879274 573 IVFVTNYPLTISGKIQK 589
Cdd:PRK12316 3519 LLFLERMPLTPNGKLDR 3535
|
|
| LC_FACS_bac1 |
cd17641 |
bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial ... |
101-540 |
2.62e-22 |
|
bacterial long-chain fatty acid CoA synthetase; The members of this family are bacterial long-chain fatty acid CoA synthetase, most of which are as yet uncharacterized. LC-FACS catalyzes the formation of fatty acyl-CoA in a two-step reaction: the formation of a fatty acyl-AMP molecule as an intermediate, and the formation of a fatty acyl-CoA. Free fatty acids must be "activated" to their CoA thioesters before participating in most catabolic and anabolic reactions.
Pssm-ID: 341296 [Multi-domain] Cd Length: 569 Bit Score: 100.96 E-value: 2.62e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 101 TFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLAtAQAM--------------ELEYVLKKVGCKALVFPK 166
Cdd:cd17641 13 TWADYADRVRAFALGLLALGVGRGDVVAILGDNRPEWVWAELA-AQAIgalslgiyqdsmaeEVAYLLNYTGARVVIAED 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 167 QFKTQQYYNVLKQIcPEVENA---QPGALKSQRLPDLttvisvdaplpgtLLLDEVVAAGSTRQHLDQLQYNQQFLSCH- 242
Cdd:cd17641 92 EEQVDKLLEIADRI-PSVRYViycDPRGMRKYDDPRL-------------ISFEDVVALGRALDRRDPGLYEREVAAGKg 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 243 -DPINIQFTSGTTGSPKGATLSHYNIVNNSNILgerLKLHEKTP-EQLRMILPNP-----------------LYHCLGSV 303
Cdd:cd17641 158 eDVAVLCTTSGTTGKPKLAMLSHGNFLGHCAAY---LAADPLGPgDEYVSVLPLPwigeqmysvgqalvcgfIVNFPEEP 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 304 AgTMMCLM--YGATLILASP-----------------------IFN-----GKKALEAISRER--GTFLYGTPTMFVDIL 351
Cdd:cd17641 235 E-TMMEDLreIGPTFVLLPPrvwegiaadvrarmmdatpfkrfMFElgmklGLRALDRGKRGRpvSLWLRLASWLADALL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 352 NQPDFSSYDISTMCGGVIAGSPAPPELIR---AIinKINMKDLvvaYGTTENSPVTFAHfPEDTVeqKAESVGRIMPHTE 428
Cdd:cd17641 314 FRPLRDRLGFSRLRSAATGGAALGPDTFRffhAI--GVPLKQL---YGQTELAGAYTVH-RDGDV--DPDTVGVPFPGTE 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 429 ARIMNMeagtlaklntpGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKD-MIIRGGENI 507
Cdd:cd17641 386 VRIDEV-----------GEILVRSPGVFVGYYKNPEATAEDFDEDGWLHTGDAGYFKENGHLVVIDRAKDvGTTSDGTRF 454
|
490 500 510
....*....|....*....|....*....|...
gi 572879274 508 YPAELEDFFHTHPKVQEVQVVGVKDDRMGEEIC 540
Cdd:cd17641 455 SPQFIENKLKFSPYIAEAVVLGAGRPYLTAFIC 487
|
|
| PRK09274 |
PRK09274 |
peptide synthase; Provisional |
78-548 |
3.77e-22 |
|
peptide synthase; Provisional
Pssm-ID: 236443 [Multi-domain] Cd Length: 552 Bit Score: 100.36 E-value: 3.77e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 78 LETTAQRVPEREALVVLH--------EDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLgmwgpnsyawVLMQLATAQAME 149
Cdd:PRK09274 12 LPRAAQERPDQLAVAVPGgrgadgklAYDELSFAELDARSDAIAHGLNAAGIGRGMRA----------VLMVTPSLEFFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 150 LEYVLKKVGCKA-LVFP----KQFKTqqyynVLKQICPEVENAQPGALKSQRL-----PDLTTVISVDAPL-PGTLLLDE 218
Cdd:PRK09274 82 LTFALFKAGAVPvLVDPgmgiKNLKQ-----CLAEAQPDAFIGIPKAHLARRLfgwgkPSVRRLVTVGGRLlWGGTTLAT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 219 VvaagstRQHLDQLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHynivnnSNILGERLKLHEktpeqLRMILPN---- 294
Cdd:PRK09274 157 L------LRDGAAAPFPMADLAPDDMAAILFTSGSTGTPKGVVYTH------GMFEAQIEALRE-----DYGIEPGeidl 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 295 ---PLYHCLGSVAGtmmclmyGATLI----LASPIF-NGKKALEAISRERGTFLYGTPTMFVDIL-----NQPDFSSydI 361
Cdd:PRK09274 220 ptfPLFALFGPALG-------MTSVIpdmdPTRPATvDPAKLFAAIERYGVTNLFGSPALLERLGrygeaNGIKLPS--L 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 362 STmcggVI-AGSPAPPELI---RAIINkiNMKDLVVAYGTTENSPVTF----AHFpEDTVEQKAES----VGRIMPHTEA 429
Cdd:PRK09274 291 RR----VIsAGAPVPIAVIerfRAMLP--PDAEILTPYGATEALPISSiesrEIL-FATRAATDNGagicVGRPVDGVEV 363
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 430 RIMNMEAGTLA------KLNTP--GELCIRGYCVMLGYWGEPQKTEEA----VDQDKWYWTGDVATMNEQG---FCkivG 494
Cdd:PRK09274 364 RIIAISDAPIPewddalRLATGeiGEIVVAGPMVTRSYYNRPEATRLAkipdGQGDVWHRMGDLGYLDAQGrlwFC---G 440
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 572879274 495 RSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDrmGEEICA-CIRLKDG 548
Cdd:PRK09274 441 RKAHRVETAGGTLYTIPCERIFNTHPGVKRSALVGVGVP--GAQRPVlCVELEPG 493
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
71-589 |
4.16e-22 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 101.96 E-value: 4.16e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 71 SKTVGQCLETTAQRVPEreALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLckgdrlgmwGPNSYAWVLMQLATAQAMEL 150
Cdd:PRK12316 4550 TRCVHQLVAERARMTPD--AVAVVFDEEKLTYAELNRRANRLAHALIARGV---------GPEVLVGIAMERSAEMMVGL 4618
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 151 EYVLKKVGCKALVFPKQFKTQQYYnvlkqicpEVENAQPGALKSQRlpdlttviSVDAPLPgtllldevVAAGSTRQHLD 230
Cdd:PRK12316 4619 LAVLKAGGAYVPLDPEYPRERLAY--------MMEDSGAALLLTQS--------HLLQRLP--------IPDGLASLALD 4674
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 231 QLQYNQQFlSCHDPIN---------IQFTSGTTGSPKGATLSHYNIVNNSNILGERlklHEKTPEQLRMILPNplYHCLG 301
Cdd:PRK12316 4675 RDEDWEGF-PAHDPAVrlhpdnlayVIYTSGSTGRPKGVAVSHGSLVNHLHATGER---YELTPDDRVLQFMS--FSFDG 4748
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 302 SVAGTMMCLMYGATLILASP-IFNGKKALEAISRERGTFLYGTPTMFVDILNQP--DFSSYDISTMCGGviaGSPAPPEL 378
Cdd:PRK12316 4749 SHEGLYHPLINGASVVIRDDsLWDPERLYAEIHEHRVTVLVFPPVYLQQLAEHAerDGEPPSLRVYCFG---GEAVAQAS 4825
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 379 IRAIINKINMKDLVVAYGTTENS--PVTFAHFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAkLNTPGELCIRGYCVM 456
Cdd:PRK12316 4826 YDLAWRALKPVYLFNGYGPTETTvtVLLWKARDGDACGAAYMPIGTPLGNRSGYVLDGQLNPLP-VGVAGELYLGGEGVA 4904
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 457 LGYWGEPQKTEEAVDQD-------KWYWTGDVATMNEQGFCKIVGRSKDMI-IRGGEnIYPAELEDFFHTHPKVQEVQVV 528
Cdd:PRK12316 4905 RGYLERPALTAERFVPDpfgapggRLYRTGDLARYRADGVIDYLGRVDHQVkIRGFR-IELGEIEARLREHPAVREAVVI 4983
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 572879274 529 GVkDDRMGEEICACI-----RLKDGEETTVE---EIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQK 589
Cdd:PRK12316 4984 AQ-EGAVGKQLVGYVvpqdpALADADEAQAElrdELKAALRERLPEYMVPAHLVFLARMPLTPNGKLDR 5051
|
|
| A_NRPS_CmdD_like |
cd17652 |
similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) ... |
243-592 |
1.09e-21 |
|
similar to adenylation domain of chondramide synthase cmdD; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes phosphinothricin tripeptide (PTT, phosphinothricylalanylalanine) synthetase, where PTT is a natural-product antibiotic and potent herbicide that is produced by Streptomyces hygroscopicus. This adenylation domain has been confirmed to directly activate beta-tyrosine, and fluorinated chondramides are produced through precursor-directed biosynthesis. Also included in this family is chondramide synthase D (also known as ATP-dependent phenylalanine adenylase or phenylalanine activase or tyrosine activase). Chondramides A-D are depsipeptide antitumor and antifungal antibiotics produced by C. crocatus, are a class of mixed peptide/polyketide depsipeptides comprised of three amino acids (alanine, N-methyltryptophan, plus the unusual amino acid beta-tyrosine or alpha-methoxy-beta-tyrosine) and a polyketide chain ([E]-7-hydroxy-2,4,6-trimethyloct-4-enoic acid).
Pssm-ID: 341307 [Multi-domain] Cd Length: 436 Bit Score: 98.09 E-value: 1.09e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 243 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQLRMILPNPLYHclGSVAGTMMCLMYGATLILA--S 320
Cdd:cd17652 94 NLAYVIYTSGSTGRPKGVVVTHRGLANLAAAQIAAFDV---GPGSRVLQFASPSFD--ASVWELLMALLAGATLVLApaE 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 321 PIFNGKKALEAISRERGTFLYGTPTMfVDILnqPDFSSYDISTMcggVIAGSPAPPELI------RAIINkinmkdlvvA 394
Cdd:cd17652 169 ELLPGEPLADLLREHRITHVTLPPAA-LAAL--PPDDLPDLRTL---VVAGEACPAELVdrwapgRRMIN---------A 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 395 YGTTE---NSPVTFAHFPEDTVeqkaeSVGRIMPHTEARIMNmeagtlAKLN-----TPGELCIRGYCVMLGYWGEPQKT 466
Cdd:cd17652 234 YGPTEttvCATMAGPLPGGGVP-----PIGRPVPGTRVYVLD------ARLRpvppgVPGELYIAGAGLARGYLNRPGLT 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 467 EEAVDQD-------KWYWTGDVATMNEQGFCKIVGRSKDMI-IRGgENIYPAELEDFFHTHPKVQEVqVVGVKDDRMGEE 538
Cdd:cd17652 303 AERFVADpfgapgsRMYRTGDLARWRADGQLEFLGRADDQVkIRG-FRIELGEVEAALTEHPGVAEA-VVVVRDDRPGDK 380
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 572879274 539 -ICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKL 592
Cdd:cd17652 381 rLVAYVVPAPGAAPTAAELRAHLAERLPGYMVPAAFVVLDALPLTPNGKLDRRAL 435
|
|
| FATP_chFAT1_like |
cd05937 |
Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA ... |
249-595 |
1.29e-21 |
|
Uncharacterized subfamily of bifunctional fatty acid transporter/very-long-chain acyl-CoA synthetase in fungi; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis. Members of this family are fungal FATPs, including FAT1 from Cochliobolus heterostrophus.
Pssm-ID: 341260 [Multi-domain] Cd Length: 468 Bit Score: 98.27 E-value: 1.29e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 249 FTSGTTGSPKGATLSHYNIVNNSNILGErlKLHEKTPeqLRMILPNPLYHCLGSVAGTMMCLMYGATLILaSPIFNGKKA 328
Cdd:cd05937 94 YTSGTTGLPKAAAISWRRTLVTSNLLSH--DLNLKNG--DRTYTCMPLYHGTAAFLGACNCLMSGGTLAL-SRKFSASQF 168
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 329 LEAISRERGTFLYGTPTMFVDILNQPDfSSYDISTMCGgVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHF 408
Cdd:cd05937 169 WKDVRDSGATIIQYVGELCRYLLSTPP-SPYDRDHKVR-VAWGNGLRPDIWERFRERFNVPEIGEFYAATEGVFALTNHN 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 409 PEDTVEQKAESVGRIM--------------PHTEARIMNMEAG--TLAKLNTPGELCIRGYCVML----GYWGEPQKTEE 468
Cdd:cd05937 247 VGDFGAGAIGHHGLIRrwkfenqvvlvkmdPETDDPIRDPKTGfcVRAPVGEPGEMLGRVPFKNReafqGYLHNEDATES 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 469 AVDQ------DKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVK----DDRMGee 538
Cdd:cd05937 327 KLVRdvfrkgDIYFRTGDLLRQDADGRWYFLDRLGDTFRWKSENVSTTEVADVLGAHPDIAEANVYGVKvpghDGRAG-- 404
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 572879274 539 iCACIRLKDGEETTVEEIKA----FCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:cd05937 405 -CAAITLEESSAVPTEFTKSllasLARKNLPSYAVPLFLRLTEEVATTDNHKQQKGVLRDE 464
|
|
| A_NRPS_ApnA-like |
cd17644 |
similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the ... |
247-587 |
3.35e-21 |
|
similar to adenylation domain of anabaenopeptin synthetase (ApnA); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Planktothrix agardhii anabaenopeptin synthetase (ApnA A1), which is capable of activating two chemically distinct amino acids (Arg and Tyr). Structural studies show that the architecture of the active site forces Arg to adopt a Tyr-like conformation, thus explaining the bispecificity. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341299 [Multi-domain] Cd Length: 465 Bit Score: 96.74 E-value: 3.35e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 247 IQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhektPEQLRmILPNPLYHCLGSVAGTMMCLMYGATLIL--ASPIFN 324
Cdd:cd17644 111 VIYTSGSTGKPKGVMIEHQSLVNLSHGLIKEYGI----TSSDR-VLQFASIAFDVAAEEIYVTLLSGATLVLrpEEMRSS 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 325 GKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPA-PPELIR----AIINKINmkdLVVAYGTTE 399
Cdd:cd17644 186 LEDFVQYIQQWQLTVLSLPPAYWHLLVLELLLSTIDLPSSLRLVIVGGEAvQPELVRqwqkNVGNFIQ---LINVYGPTE 262
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 400 NS-PVTFAHFPEDTVEQKAE-SVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQD---- 473
Cdd:cd17644 263 ATiAATVCRLTQLTERNITSvPIGRPIANTQVYILD-ENLQPVPVGVPGELHIGGVGLARGYLNRPELTAEKFISHpfns 341
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 474 ----KWYWTGDVATMNEQGFCKIVGRSKDMI-IRGGEnIYPAELEDFFHTHPKVQEVqVVGVKDDRMGEE-ICACIRLKD 547
Cdd:cd17644 342 seseRLYKTGDLARYLPDGNIEYLGRIDNQVkIRGFR-IELGEIEAVLSQHNDVKTA-VVIVREDQPGNKrLVAYIVPHY 419
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 572879274 548 GEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:cd17644 420 EESPSTVELRQFLKAKLPDYMIPSAFVVLEELPLTPNGKI 459
|
|
| PRK05851 |
PRK05851 |
long-chain-fatty acid--ACP ligase MbtM; |
228-597 |
3.98e-21 |
|
long-chain-fatty acid--ACP ligase MbtM;
Pssm-ID: 180289 [Multi-domain] Cd Length: 525 Bit Score: 97.14 E-value: 3.98e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 228 HLDQLQYNQQFLSCHD--------------------PINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQ 287
Cdd:PRK05851 118 HLERLRAVDSSVTVHDlataahtnrsasltppdsggPAVLQGTAGSTGTPRTAILSPGAVLSNLRGLNARVGLDAATDVG 197
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 288 LRMIlpnPLYHCLGsVAGTMMCLMYGATLILA-------SPIfngkKALEAISRERGTFLYGtPTMFVDILNQ--PDFSS 358
Cdd:PRK05851 198 CSWL---PLYHDMG-LAFLLTAALAGAPLWLApttafsaSPF----RWLSWLSDSRATLTAA-PNFAYNLIGKyaRRVSD 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 359 YDISTMCGGVIAGSPAPPELIRAIINKI-----NMKDLVVAYGTTENS-------PVTFAHF-----PEDTVEQKAESVG 421
Cdd:PRK05851 269 VDLGALRVALNGGEPVDCDGFERFATAMapfgfDAGAAAPSYGLAESTcavtvpvPGIGLRVdevttDDGSGARRHAVLG 348
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 422 RIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPqkteeAVDQDKWYWTGDVATMNEQGFCkIVGRSKDMII 501
Cdd:PRK05851 349 NPIPGMEVRISPGDGAAGVAGREIGEIEIRGASMMSGYLGQA-----PIDPDDWFPTGDLGYLVDGGLV-VCGRAKELIT 422
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 502 RGGENIYPAELEDFFHTHPKVQEVQVVGVKDD----RMGEEICACIRLKDgEETT----VEEIKAFCKgkishfKIPKYI 573
Cdd:PRK05851 423 VAGRNIFPTEIERVAAQVRGVREGAVVAVGTGegsaRPGLVIAAEFRGPD-EAGArsevVQRVASECG------VVPSDV 495
|
410 420
....*....|....*....|....*.
gi 572879274 574 VFVT--NYPLTISGKIQKFKLREQME 597
Cdd:PRK05851 496 VFVApgSLPRTSSGKLRRLAVKRSLE 521
|
|
| AACS |
cd05943 |
Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that ... |
84-588 |
5.53e-21 |
|
Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); AACS is a cytosolic ligase that specifically activates acetoacetate to its coenzyme A ester by a two-step reaction. Acetoacetate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is the first step of the mevalonate pathway of isoprenoid biosynthesis via isopentenyl diphosphate. Isoprenoids are a large class of compounds found in all living organisms. AACS is widely distributed in bacteria, archaea and eukaryotes. In bacteria, AACS is known to exhibit an important role in the metabolism of poly-b-hydroxybutyrate, an intracellular reserve of organic carbon and chemical energy by some microorganisms. In mammals, AACS influences the rate of ketone body utilization for the formation of physiologically important fatty acids and cholesterol.
Pssm-ID: 341265 [Multi-domain] Cd Length: 629 Bit Score: 96.96 E-value: 5.53e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 84 RVPEREALVVLHED---VRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATA----------QAMEL 150
Cdd:cd05943 80 ADADDPAAIYAAEDgerTEVTWAELRRRVARLAAALRALGVKPGDRVAGYLPNIPEAVVAMLATAsigaiwsscsPDFGV 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 151 EYVLKKVGckaLVFPK-QFKTQQY-YNVlKQIC--PEVENAQPGalksqrLPDLTTVISVD----------APLPGTLLL 216
Cdd:cd05943 160 PGVLDRFG---QIEPKvLFAVDAYtYNG-KRHDvrEKVAELVKG------LPSLLAVVVVPytvaagqpdlSKIAKALTL 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 217 DEVVAAGSTRQ-HLDQLQYNqqflschDPINIQFTSGTTGSPKGATLSHynivnnSNILGERLKLHektpeqlrmILPNP 295
Cdd:cd05943 230 EDFLATGAAGElEFEPLPFD-------HPLYILYSSGTTGLPKCIVHGA------GGTLLQHLKEH---------ILHCD 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 296 LYH----CLGSVAGTMM------CLMYGATLIL--ASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQPDFS---SYD 360
Cdd:cd05943 288 LRPgdrlFYYTTCGWMMwnwlvsGLAVGATIVLydGSPFYPDTNALWDLADEEGITVFGTSAKYLDALEKAGLKpaeTHD 367
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 361 ISTMCGGVIAGSPAPPELIRAIINKINmKDLVVAY---GTTENSpvTFA-HFPEDTV---EQKAESVGRIMphteaRIMN 433
Cdd:cd05943 368 LSSLRTILSTGSPLKPESFDYVYDHIK-PDVLLASisgGTDIIS--CFVgGNPLLPVyrgEIQCRGLGMAV-----EAFD 439
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 434 mEAGTlAKLNTPGEL-CIRGY-CVMLGYWGEP--QKTEEA-VDQDKWYWT-GDVATMNEQGFCKIVGRSKDMIIRGGENI 507
Cdd:cd05943 440 -EEGK-PVWGEKGELvCTKPFpSMPVGFWNDPdgSRYRAAyFAKYPGVWAhGDWIEITPRGGVVILGRSDGTLNPGGVRI 517
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 508 YPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETT---VEEIKAFCKGKISHFKIPKYIVFVTNYPLTIS 584
Cdd:cd05943 518 GTAEIYRVVEKIPEVEDSLVVGQEWKDGDERVILFVKLREGVELDdelRKRIRSTIRSALSPRHVPAKIIAVPDIPRTLS 597
|
....
gi 572879274 585 GKIQ 588
Cdd:cd05943 598 GKKV 601
|
|
| PRK08308 |
PRK08308 |
acyl-CoA synthetase; Validated |
242-594 |
7.89e-21 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236231 [Multi-domain] Cd Length: 414 Bit Score: 95.10 E-value: 7.89e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 242 HDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKlhekTPEQLRMILPNPLYHCLGSVAGTMMCLMYGAT-LILAS 320
Cdd:PRK08308 101 EEPSLLQYSSGTTGEPKLIRRSWTEIDREIEAYNEALN----CEQDETPIVACPVTHSYGLICGVLAALTRGSKpVIITN 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 321 PifNGKKALEAISRERGTFLYGTPTMFVDI--LNQPDFSSYDISTmcggviAGSPAPPELIRAIINKINMkdLVVAYGTT 398
Cdd:PRK08308 177 K--NPKFALNILRNTPQHILYAVPLMLHILgrLLPGTFQFHAVMT------SGTPLPEAWFYKLRERTTY--MMQQYGCS 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 399 ENSPVTFAHFPEDtveqkAESVGRIMPHteariMNMEAGTlaKLNTPGELCIRgycvmlgywgepQKTEEAVDQDKWYWT 478
Cdd:PRK08308 247 EAGCVSICPDMKS-----HLDLGNPLPH-----VSVSAGS--DENAPEEIVVK------------MGDKEIFTKDLGYKS 302
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 479 gdvatmnEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICAciRLKDGEETTVEEIKA 558
Cdd:PRK08308 303 -------ERGTLHFMGRMDDVINVSGLNVYPIEVEDVMLRLPGVQEAVVYRGKDPVAGERVKA--KVISHEEIDPVQLRE 373
|
330 340 350
....*....|....*....|....*....|....*.
gi 572879274 559 FCKGKISHFKIPKYIVFVTNYPLTISGKIQKfKLRE 594
Cdd:PRK08308 374 WCIQHLAPYQVPHEIESVTEIPKNANGKVSR-KLLE 408
|
|
| PRK09192 |
PRK09192 |
fatty acyl-AMP ligase; |
100-594 |
9.30e-21 |
|
fatty acyl-AMP ligase;
Pssm-ID: 236403 [Multi-domain] Cd Length: 579 Bit Score: 96.23 E-value: 9.30e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 100 LTFAQLKEEVDKAASGLLSIGLCKGDRLGMwgpnsyawvlmqLATAQAmelEYVLKKVGCK-------ALVFPKQFKTQQ 172
Cdd:PRK09192 50 LPYQTLRARAEAGARRLLALGLKPGDRVAL------------IAETDG---DFVEAFFACQyaglvpvPLPLPMGFGGRE 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 173 YYnvLKQICPEVENAQPGAL-KSQRLPDLTTVISVDAPLPGTL---LLDEVVAAGstrqhlDQLQYNQQflscHDPINIQ 248
Cdd:PRK09192 115 SY--IAQLRGMLASAQPAAIiTPDELLPWVNEATHGNPLLHVLshaWFKALPEAD------VALPRPTP----DDIAYLQ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 249 FTSGTTGSPKGATLSHYNIVNN-SNILGERLKLHEKTpeqlRMILPNPLYH------CLGSVAGTMMCLMYGATLILA-S 320
Cdd:PRK09192 183 YSSGSTRFPRGVIITHRALMANlRAISHDGLKVRPGD----RCVSWLPFYHdmglvgFLLTPVATQLSVDYLPTRDFArR 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 321 PIfngkKALEAISRERGTFLYgTPTMFVDI----LNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKI-----NMKDL 391
Cdd:PRK09192 259 PL----QWLDLISRNRGTISY-SPPFGYELcarrVNSKDLAELDLSCWRVAGIGADMIRPDVLHQFAEAFapagfDDKAF 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 392 VVAYGTTENS-PVTFAhfPE------DTVE-------QKAESV-------------GRIMPHTEARIMNmEAGTLAKLNT 444
Cdd:PRK09192 334 MPSYGLAEATlAVSFS--PLgsgivvEEVDrdrleyqGKAVAPgaetrrvrtfvncGKALPGHEIEIRN-EAGMPLPERV 410
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 445 PGELCIRGYCVMLGYWGEpQKTEEAVDQDKWYWTGDVATMNEqGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQ- 523
Cdd:PRK09192 411 VGHICVRGPSLMSGYFRD-EESQDVLAADGWLDTGDLGYLLD-GYLYITGRAKDLIIINGRNIWPQDIEWIAEQEPELRs 488
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 572879274 524 -EVQVVGVKDDRmGEEICACIRLKDGEETTVEEIKAFCKGKI-SHFKIPKYIVFVTNY--PLTISGKIQKFKLRE 594
Cdd:PRK09192 489 gDAAAFSIAQEN-GEKIVLLVQCRISDEERRGQLIHALAALVrSEFGVEAAVELVPPHslPRTSSGKLSRAKAKK 562
|
|
| A_NRPS_TlmIV_like |
cd12114 |
The adenylation domain of nonribosomal peptide synthetases (NRPS), including ... |
89-587 |
1.21e-20 |
|
The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions. This family includes the TLM biosynthetic gene cluster from Streptoalloteichus that consists of nine NRPS genes; the N-terminal module of TlmVI (NRPS-5) and the starter module of BlmVI (NRPS-5) are comprised of the acyl CoA ligase (AL) and acyl carrier protein (ACP)-like domains, which are thought to be involved in the biosynthesis of the beta-aminoalaninamide moiety.
Pssm-ID: 341279 [Multi-domain] Cd Length: 477 Bit Score: 95.42 E-value: 1.21e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 89 EALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQA-------------MELEYVLK 155
Cdd:cd12114 2 DATAVICGDGTLTYGELAERARRVAGALKAAGVRPGDLVAVTLPKGPEQVVAVLGILAAgaayvpvdidqpaARREAILA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 156 KVGCKALVfpkqfktqqyynvlkqicpeveNAQPGALKSQRLPDLTTVISVDAPLPGTLLldevvaagSTRQHLDQLQYn 235
Cdd:cd12114 82 DAGARLVL----------------------TDGPDAQLDVAVFDVLILDLDALAAPAPPP--------PVDVAPDDLAY- 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 236 qqflschdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQlRMILPNPLYHCLgSVAGTMMCLMYGAT 315
Cdd:cd12114 131 -----------VIFTSGSTGTPKGVMISHRAALNTILDINRRFAV---GPDD-RVLALSSLSFDL-SVYDIFGALSAGAT 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 316 LILASPIFNGKKA--LEAISRERGTFLYGTPT---MFVDIL--NQPDFSSYDISTMCGGVIAgsPAPPELIRAIINKINm 388
Cdd:cd12114 195 LVLPDEARRRDPAhwAELIERHGVTLWNSVPAlleMLLDVLeaAQALLPSLRLVLLSGDWIP--LDLPARLRALAPDAR- 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 389 kdLVVAYGTTENSPVTFAHfPEDTVEQKAESV--GRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKT 466
Cdd:cd12114 272 --LISLGGATEASIWSIYH-PIDEVPPDWRSIpyGRPLANQRYRVLD-PRGRDCPDWVPGELWIGGRGVALGYLGDPELT 347
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 467 EEA----VDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVkDDRMGEEICAC 542
Cdd:cd12114 348 AARfvthPDGERLYRTGDLGRYRPDGTLEFLGRRDGQVKVRGYRIELGEIEAALQAHPGVARAVVVVL-GDPGGKRLAAF 426
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 572879274 543 IRLK-DGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:cd12114 427 VVPDnDGTPIAPDALRAFLAQTLPAYMIPSRVIALEALPLTANGKV 472
|
|
| AMP-binding_C |
pfam13193 |
AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to ... |
511-586 |
1.22e-20 |
|
AMP-binding enzyme C-terminal domain; This is a small domain that is found C terminal to pfam00501. It has a central beta sheet core that is flanked by alpha helices.
Pssm-ID: 463804 [Multi-domain] Cd Length: 76 Bit Score: 86.06 E-value: 1.22e-20
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 572879274 511 ELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGK 586
Cdd:pfam13193 1 EVESALVSHPAVAEAAVVGVPDELKGEAPVAFVVLKPGVELLEEELVAHVREELGPYAVPKEVVFVDELPKTRSGK 76
|
|
| PRK07867 |
PRK07867 |
acyl-CoA synthetase; Validated |
249-595 |
1.27e-20 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 236120 [Multi-domain] Cd Length: 529 Bit Score: 95.52 E-value: 1.27e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 249 FTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMilpnPLYHCLGSVAGTMMCLMYGATLILaSPIFNGKKA 328
Cdd:PRK07867 159 FTSGTSGDPKAVRCTHRKVASAGVMLAQRFGLGPDDVCYVSM----PLFHSNAVMAGWAVALAAGASIAL-RRKFSASGF 233
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 329 LEAISRERGTFL-Y-GTPTMFvdIL---NQPDFSSYDISTMcggviAGSPAPPELIRAIINKINMKdLVVAYGTTENSpV 403
Cdd:PRK07867 234 LPDVRRYGATYAnYvGKPLSY--VLatpERPDDADNPLRIV-----YGNEGAPGDIARFARRFGCV-VVDGFGSTEGG-V 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 404 TFAHFPeDTveqKAESVGRIMPHTEarIMNMEAGT---------LAKLNTP---GELC-IRGYCVMLGYWGEPQKTEEAV 470
Cdd:PRK07867 305 AITRTP-DT---PPGALGPLPPGVA--IVDPDTGTecppaedadGRLLNADeaiGELVnTAGPGGFEGYYNDPEADAERM 378
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 471 dQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEE 550
Cdd:PRK07867 379 -RGGVYWSGDLAYRDADGYAYFAGRLGDWMRVDGENLGTAPIERILLRYPDATEVAVYAVPDPVVGDQVMAALVLAPGAK 457
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 572879274 551 TTVEEIKAFCKGK--ISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:PRK07867 458 FDPDAFAEFLAAQpdLGPKQWPSYVRVCAELPRTATFKVLKRQLSAE 504
|
|
| A_NRPS_PpsD_like |
cd17650 |
similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation ... |
243-587 |
2.94e-20 |
|
similar to adenylation domain of plipastatin synthase (PpsD); This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes bacitracin synthetase 1 (BacA) in Bacillus licheniformis, tyrocidine synthetase in Brevibacillus brevis, plipastatin synthase (PpsD, an important antifungal protein) in Bacillus subtilis and mannopeptimycin peptide synthetase (MppB) in Streptomyces hygroscopicus. Plipastatin has strong fungitoxic activity and is involved in inhibition of phospholipase A2 and biofilm formation. Bacitracin, a mixture of related cyclic peptides, is used as a polypeptide antibiotic while function of tyrocidine is thought to be regulation of sporulation. MppB is involved in biosynthetic pathway of mannopeptimycin, a novel class of mannosylated lipoglycopeptides. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341305 [Multi-domain] Cd Length: 447 Bit Score: 93.69 E-value: 2.94e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 243 DPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMilpnplyhclGSV-----AGTMM-CLMYGATL 316
Cdd:cd17650 94 DLAYVIYTSGTTGKPKGVMVEHRNVAHAAHAWRREYELDSFPVRLLQM----------ASFsfdvfAGDFArSLLNGGTL 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 317 ILASP--IFNGKKALEAISRERGTFLYGTPTMFVDIL-----NQPDFSSYDIsTMCGGVIAGSPAPPELIRAIINKINmk 389
Cdd:cd17650 164 VICPDevKLDPAALYDLILKSRITLMESTPALIRPVMayvyrNGLDLSAMRL-LIVGSDGCKAQDFKTLAARFGQGMR-- 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 390 dLVVAYGTTENSpVTFAHFPEDTVEQKAES---VGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKT 466
Cdd:cd17650 241 -IINSYGVTEAT-IDSTYYEEGRDPLGDSAnvpIGRPLPNTAMYVLD-ERLQPQPVGVAGELYIGGAGVARGYLNRPELT 317
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 467 EEAVDQDKW------YWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEIC 540
Cdd:cd17650 318 AERFVENPFapgermYRTGDLARWRADGNVELLGRVDHQVKIRGFRIELGEIESQLARHPAIDEAVVAVREDKGGEARLC 397
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 572879274 541 ACIRLKDGEETTveEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:cd17650 398 AYVVAAATLNTA--ELRAFLAKELPSYMIPSYYVQLDALPLTPNGKV 442
|
|
| PRK08043 |
PRK08043 |
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase; |
247-497 |
3.30e-20 |
|
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;
Pssm-ID: 181207 [Multi-domain] Cd Length: 718 Bit Score: 94.78 E-value: 3.30e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 247 IQFTSGTTGSPKGATLSHYNIVNNSnilgerlklhektpEQLRMI---LPN-------PLYHCLGSVAGTMMCLMYGATL 316
Cdd:PRK08043 370 ILFTSGSEGHPKGVVHSHKSLLANV--------------EQIKTIadfTPNdrfmsalPLFHSFGLTVGLFTPLLTGAEV 435
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 317 IL-ASPIfNGKKALEAISRERGTFLYGTPTMfvdILNQPDFSS-YDISTMcGGVIAGSPAPPELIRAI-INKINMKDLVv 393
Cdd:PRK08043 436 FLyPSPL-HYRIVPELVYDRNCTVLFGTSTF---LGNYARFANpYDFARL-RYVVAGAEKLQESTKQLwQDKFGLRILE- 509
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 394 AYGTTENSPVTFAHFPedtVEQKAESVGRIMPHTEARIMNMeagtlAKLNTPGELCIRGYCVMLGYW-----GE---PQ- 464
Cdd:PRK08043 510 GYGVTECAPVVSINVP---MAAKPGTVGRILPGMDARLLSV-----PGIEQGGRLQLKGPNIMNGYLrvekpGVlevPTa 581
|
250 260 270
....*....|....*....|....*....|...
gi 572879274 465 KTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSK 497
Cdd:PRK08043 582 ENARGEMERGWYDTGDIVRFDEQGFVQIQGRAK 614
|
|
| A_NRPS_Cytc1-like |
cd17643 |
similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation ... |
86-589 |
1.62e-19 |
|
similar to adenylation domain of cytotrienin synthetase CytC1; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) includes Streptomyces sp. cytotrienin synthetase (CytC1), a relatively promiscuous adenylation enzyme that installs the aminoacyl moieties on the phosphopantetheinyl arm of the holo carrier protein CytC2. Also included are Streptomyces sp Thr1, involved in the biosynthesis of 4-chlorothreonine, Pseudomonas aeruginosa pyoverdine synthetase D (PvdD), involved in the biosynthesis of the siderophore pyoverdine and Pseudomonas syringae syringopeptin synthetase, where syringpeptin is a necrosis-inducing phytotoxin that functions as a virulence determinant in the plant-pathogen interaction. The adenylation (A) domain of NRPS recognizes a specific amino acid or hydroxy acid and activates it as an (amino) acyl adenylate by hydrolysis of ATP. The activated acyl moiety then forms a thioester bond to the enzyme-bound cofactor phosphopantetheine of a peptidyl carrier protein domain. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341298 [Multi-domain] Cd Length: 450 Bit Score: 91.60 E-value: 1.62e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 86 PEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLAtaqameleyVLKKVGckALVfp 165
Cdd:cd17643 1 PEAVAVV--DEDRRLTYGELDARANRLARTLRAEGVGPGDRVALALPRSAELIVALLA---------ILKAGG--AYV-- 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 166 kqfktqqyynvlkqicPeVENAQPGALKSQRLPDLTTVISVDAPlpgtllldevvaagstrqhlDQLQYnqqflschdpi 245
Cdd:cd17643 66 ----------------P-IDPAYPVERIAFILADSGPSLLLTDP--------------------DDLAY----------- 97
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 246 nIQFTSGTTGSPKGATLSHYNIvnnsnilgerLKLHEKTPEQLRMilpNP-----LYHCLG---SVAGTMMCLMYGATLI 317
Cdd:cd17643 98 -VIYTSGSTGRPKGVVVSHANV----------LALFAATQRWFGF---NEddvwtLFHSYAfdfSVWEIWGALLHGGRLV 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 318 LASP-IFNGKKALEAISRERG-TFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMK--DLVV 393
Cdd:cd17643 164 VVPYeVARSPEDFARLLRDEGvTVLNQTPSAFYQLVEAADRDGRDPLALRYVIFGGEALEAAMLRPWAGRFGLDrpQLVN 243
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 394 AYGTTENSP-VTFAHF-PEDTVEQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEE--- 468
Cdd:cd17643 244 MYGITETTVhVTFRPLdAADLPAAAASPIGRPLPGLRVYVLD-ADGRPVPPGVVGELYVSGAGVARGYLGRPELTAErfv 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 469 ----AVDQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRGgENIYPAELEDFFHTHPKVQEVqVVGVKDDRMGEE-ICAC 542
Cdd:cd17643 323 anpfGGPGSRMYRTGDLARRLPDGELEYLGRADEQVkIRG-FRIELGEIEAALATHPSVRDA-AVIVREDEPGDTrLVAY 400
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 572879274 543 IRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQK 589
Cdd:cd17643 401 VVADDGAAADIAELRALLKELLPDYMVPARYVPLDALPLTVNGKLDR 447
|
|
| PRK06060 |
PRK06060 |
p-hydroxybenzoic acid--AMP ligase FadD22; |
100-595 |
1.78e-19 |
|
p-hydroxybenzoic acid--AMP ligase FadD22;
Pssm-ID: 180374 [Multi-domain] Cd Length: 705 Bit Score: 92.40 E-value: 1.78e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 100 LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAMELEYvlkkvgckaLVFPKQFKTQQYYnvlkq 179
Cdd:PRK06060 31 VTHGQIHDGAARLGEVLRNRGLSSGDRVLLCLPDSPDLVQLLLACLARGVMAF---------LANPELHRDDHAL----- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 180 icPEVENAQPGALKSQRLPDLTTVISVDAPLPgtlLLDEVVAAGSTrqhldqlqyNQQFLSCHDPINIQFTSGTTGSPKG 259
Cdd:PRK06060 97 --AARNTEPALVVTSDALRDRFQPSRVAEAAE---LMSEAARVAPG---------GYEPMGGDALAYATYTSGTTGPPKA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 260 ATLSHYNIVNNSNILGER-LKLhekTPEQLRMILPNpLYHCLGSVAGTMMCLMYGATLILASPIFNGKKALEAISRERGT 338
Cdd:PRK06060 163 AIHRHADPLTFVDAMCRKaLRL---TPEDTGLCSAR-MYFAYGLGNSVWFPLATGGSAVINSAPVTPEAAAILSARFGPS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 339 FLYGTPTMFVDILNQPDFSSYDiSTMCGgVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVtfahFPEDTVEQ-KA 417
Cdd:PRK06060 239 VLYGVPNFFARVIDSCSPDSFR-SLRCV-VSAGEALELGLAERLMEFFGGIPILDGIGSTEVGQT----FVSNRVDEwRL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 418 ESVGRIMPHTEARIMNMEaGTLAKLNTPGELCIRGYCVMLGYWGEPqktEEAVDQDKWYWTGDVATMNEQGFCKIVGRSK 497
Cdd:PRK06060 313 GTLGRVLPPYEIRVVAPD-GTTAGPGVEGDLWVRGPAIAKGYWNRP---DSPVANEGWLDTRDRVCIDSDGWVTYRCRAD 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 498 DMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGE---ETTVEEIKAFCKGKISHFKIPKYIV 574
Cdd:PRK06060 389 DTEVIGGVNVDPREVERLIIEDEAVAEAAVVAVRESTGASTLQAFLVATSGAtidGSVMRDLHRGLLNRLSAFKVPHRFA 468
|
490 500
....*....|....*....|.
gi 572879274 575 FVTNYPLTISGKIQKFKLREQ 595
Cdd:PRK06060 469 VVDRLPRTPNGKLVRGALRKQ 489
|
|
| PRK12316 |
PRK12316 |
peptide synthase; Provisional |
74-592 |
3.54e-19 |
|
peptide synthase; Provisional
Pssm-ID: 237054 [Multi-domain] Cd Length: 5163 Bit Score: 92.71 E-value: 3.54e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 74 VGQCLETTAQRVPEreALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLAtaqameleyV 153
Cdd:PRK12316 2005 VHQRIAEQAARAPE--AIAVVFGDQHLSYAELDSRANRLAHRLRARGVGPEVRVAIAAERSFELVVALLA---------V 2073
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 154 LKKVGCKALVFPKQFKTQQYYnvlkqicpEVENAQPGALKSQRlpdlttVISVDAPLPGTLLLDEVVAAGSTRQHLDQLQ 233
Cdd:PRK12316 2074 LKAGGAYVPLDPNYPAERLAY--------MLEDSGAALLLTQR------HLLERLPLPAGVARLPLDRDAEWADYPDTAP 2139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 234 YNQqfLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMIlpnplYHCLGSVAGTMMCLMYG 313
Cdd:PRK12316 2140 AVQ--LAGENLAYVIYTSGSTGLPKGVAVSHGALVAHCQAAGERYELSPADCELQFMS-----FSFDGAHEQWFHPLLNG 2212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 314 ATLIL-ASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQP--DFSSYDISTMCGGviaGSPAPPELIRAIINKINMKD 390
Cdd:PRK12316 2213 ARVLIrDDELWDPEQLYDEMERHGVTILDFPPVYLQQLAEHAerDGRPPAVRVYCFG---GEAVPAASLRLAWEALRPVY 2289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 391 LVVAYGTTENSPVTFAHF--PEDTVEQKAESVGRIMPHTEARIMNMEAGTLAkLNTPGELCIRGYCVMLGYWGEPQKTEE 468
Cdd:PRK12316 2290 LFNGYGPTEAVVTPLLWKcrPQDPCGAAYVPIGRALGNRRAYILDADLNLLA-PGMAGELYLGGEGLARGYLNRPGLTAE 2368
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 469 AVDQDKW-------YWTGDVATMNEQGFCKIVGRSKDMI-IRGGEnIYPAELEDFFHTHPKVQEVQVVGvKDDRMGEEIC 540
Cdd:PRK12316 2369 RFVPDPFsasgerlYRTGDLARYRADGVVEYLGRIDHQVkIRGFR-IELGEIEARLQAHPAVREAVVVA-QDGASGKQLV 2446
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|..
gi 572879274 541 ACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKL 592
Cdd:PRK12316 2447 AYVVPDDAAEDLLAELRAWLAARLPAYMVPAHWVVLERLPLNPNGKLDRKAL 2498
|
|
| FATP_FACS |
cd05940 |
Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its ... |
97-595 |
6.41e-19 |
|
Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. At least five copies of FATPs are identified in mammalian cells. This family also includes prokaryotic FATPs. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Pssm-ID: 341263 [Multi-domain] Cd Length: 449 Bit Score: 89.72 E-value: 6.41e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 97 DVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAqameleyvlkKVGCkalvfpkqfktqqyynv 176
Cdd:cd05940 1 DEALTYAELDAMANRYARWLKSLGLKPGDVVALFMENRPEYVLLWLGLV----------KIGA----------------- 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 177 lkqicpevenaqPGAL--KSQRLPDLTTVISVDAPLpgtllldEVVAagstrqhldqlqynqqflschDPINIQFTSGTT 254
Cdd:cd05940 54 ------------VAALinYNLRGESLAHCLNVSSAK-------HLVV---------------------DAALYIYTSGTT 93
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 255 GSPKGATLSHYNIVNNSNI---LGERLKlhektpeQLRMILPNPLYHCLGSVAGTMMCLMYGATLILASPiFNGKKALEA 331
Cdd:cd05940 94 GLPKAAIISHRRAWRGGAFfagSGGALP-------SDVLYTCLPLYHSTALIVGWSACLASGATLVIRKK-FSASNFWDD 165
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 332 ISRERGtflygtpTMFVDI-------LNQP---DFSSYDISTMCGGVIAgspapPELIRAIINKINMKDLVVAYGTTENS 401
Cdd:cd05940 166 IRKYQA-------TIFQYIgelcrylLNQPpkpTERKHKVRMIFGNGLR-----PDIWEEFKERFGVPRIAEFYAATEGN 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 402 pVTFAHFPedtveQKAESVGRIMPHTE----ARIMNMEAGTLAKLNTPGELCIR------GYCV--------MLGYWGeP 463
Cdd:cd05940 234 -SGFINFF-----GKPGAIGRNPSLLRkvapLALVKYDLESGEPIRDAEGRCIKvprgepGLLIsrinplepFDGYTD-P 306
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 464 QKTEEAV------DQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVK----DD 533
Cdd:cd05940 307 AATEKKIlrdvfkKGDAWFNTGDLMRLDGEGFWYFVDRLGDTFRWKGENVSTTEVAAVLGAFPGVEEANVYGVQvpgtDG 386
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 572879274 534 RMGeeiCACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:cd05940 387 RAG---MAAIVLQPNEEFDLSALAAHLEKNLPGYARPLFLRLQPEMEITGTFKQQKVDLRNE 445
|
|
| PTZ00216 |
PTZ00216 |
acyl-CoA synthetase; Provisional |
93-497 |
8.25e-19 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 240316 [Multi-domain] Cd Length: 700 Bit Score: 90.42 E-value: 8.25e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 93 VLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWvlmqLATA-----QAM------------ELEYVLK 155
Cdd:PTZ00216 115 HFNETRYITYAELWERIVNFGRGLAELGLTKGSNVAIYEETRWEW----LASIygiwsQSMvaatvyanlgedALAYALR 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 156 KVGCKALVFPKQfktqqyyNVLKQIcpevenaqpGALKSQRLPDlTTVISVDApLPGTLLLD--------EVVAAGSTRQ 227
Cdd:PTZ00216 191 ETECKAIVCNGK-------NVPNLL---------RLMKSGGMPN-TTIIYLDS-LPASVDTEgcrlvawtDVVAKGHSAG 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 228 hlDQLQYNQQfLSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERL-KLHEKTPEQLRMILPNPLYHCLgSVAGT 306
Cdd:PTZ00216 253 --SHHPLNIP-ENNDDLALIMYTSGTTGDPKGVMHTHGSLTAGILALEDRLnDLIGPPEEDETYCSYLPLAHIM-EFGVT 328
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 307 MMCLMYGATLILASP---------------------------IFNG-KKALEAISRERGTF-------LY---------G 342
Cdd:PTZ00216 329 NIFLARGALIGFGSPrtltdtfarphgdltefrpvfligvprIFDTiKKAVEAKLPPVGSLkrrvfdhAYqsrlralkeG 408
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 343 TPTMFvdiLNQPDFSSY------DISTMCGGVIAGSPAPPELIRAIINKInmkdlVVAYGTTENSPVTFAHFPEDTveqK 416
Cdd:PTZ00216 409 KDTPY---WNEKVFSAPravlggRVRAMLSGGGPLSAATQEFVNVVFGMV-----IQGWGLTETVCCGGIQRTGDL---E 477
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 417 AESVGRIMPHTEARIMNMEAgtLAKLNTP---GELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIV 493
Cdd:PTZ00216 478 PNAVGQLLKGVEMKLLDTEE--YKHTDTPeprGEILLRGPFLFKGYYKQEELTREVLDEDGWFHTGDVGSIAANGTLRII 555
|
....
gi 572879274 494 GRSK 497
Cdd:PTZ00216 556 GRVK 559
|
|
| A_NRPS_ProA |
cd17656 |
gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the ... |
89-592 |
1.35e-18 |
|
gramicidin S synthase 2, also known as ATP-dependent proline adenylase; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains gramicidin S synthase 2 (also known as ATP-dependent proline adenylase or proline activase or ProA). ProA is a multifunctional enzyme involved in synthesis of the cyclic peptide antibiotic gramicidin S and able to activate and polymerize the amino acids proline, valine, ornithine and leucine. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341311 [Multi-domain] Cd Length: 479 Bit Score: 89.07 E-value: 1.35e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 89 EALVVLHEDVRLTFAQLKEEVDKAASGLLSIGLckgdrlgmwGPNSYAWVLMQLATAQAMELEYVLKKVGCKALVFPKQF 168
Cdd:cd17656 3 DAVAVVFENQKLTYRELNERSNQLARFLREKGV---------KKDSIVAIMMERSAEMIVGILGILKAGGAFVPIDPEYP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 169 KTQQYYNVLKQICPEVenaqpgaLKSQRLPD-LTTVISVdaplpgTLLLDEVVAAGSTrQHLDqLQYNQQFLschdpINI 247
Cdd:cd17656 74 EERRIYIMLDSGVRVV-------LTQRHLKSkLSFNKST------ILLEDPSISQEDT-SNID-YINNSDDL-----LYI 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 248 QFTSGTTGSPKGATLSHYNIVN-------NSNILGERLKLHEKTPEQlrmilpNPLYHCLGSVagtmmcLMYGATLILAS 320
Cdd:cd17656 134 IYTSGTTGKPKGVQLEHKNMVNllhfereKTNINFSDKVLQFATCSF------DVCYQEIFST------LLSGGTLYIIR 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 321 PIF--NGKKALEAISRERGTFLYgTPTMFVDILnqpdFSSYDIStmcggviagsPAPPELIRAII---NKINMKDLVVA- 394
Cdd:cd17656 202 EETkrDVEQLFDLVKRHNIEVVF-LPVAFLKFI----FSEREFI----------NRFPTCVKHIItagEQLVITNEFKEm 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 395 -----------YGTTENSPVTFAHF-PEDTVeQKAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIRGYCVMLGYWGE 462
Cdd:cd17656 267 lhehnvhlhnhYGPSETHVVTTYTInPEAEI-PELPPIGKPISNTWIYILD-QEQQLQPQGIVGELYISGASVARGYLNR 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 463 PQKTEEAVDQDKW------YWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMG 536
Cdd:cd17656 345 QELTAEKFFPDPFdpnermYRTGDLARYLPDGNIEFLGRADHQVKIRGYRIELGEIEAQLLNHPGVSEAVVLDKADDKGE 424
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 572879274 537 EEICACIRLKdgEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKL 592
Cdd:cd17656 425 KYLCAYFVME--QELNISQLREYLAKQLPEYMIPSFFVPLDQLPLTPNGKVDRKAL 478
|
|
| PRK08279 |
PRK08279 |
long-chain-acyl-CoA synthetase; Validated |
73-595 |
1.72e-18 |
|
long-chain-acyl-CoA synthetase; Validated
Pssm-ID: 236217 [Multi-domain] Cd Length: 600 Bit Score: 89.16 E-value: 1.72e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 73 TVGQCLETTAQRVPEREALvvLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAqameley 152
Cdd:PRK08279 38 SLGDVFEEAAARHPDRPAL--LFEDQSISYAELNARANRYAHWAAARGVGKGDVVALLMENRPEYLAAWLGLA------- 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 153 vlkKVG-CKALVfpkqfKTQQYYNVLKQiCPEVenAQPGAL-------------KSQRLPDLTTVISVDAPLPGTLLLDE 218
Cdd:PRK08279 109 ---KLGaVVALL-----NTQQRGAVLAH-SLNL--VDAKHLivgeelveafeeaRADLARPPRLWVAGGDTLDDPEGYED 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 219 VVAAGSTRQHLDQLQYNQQFLSchDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLhekTPEQlRMILPNPLYH 298
Cdd:PRK08279 178 LAAAAAGAPTTNPASRSGVTAK--DTAFYIYTSGTTGLPKAAVMSHMRWLKAMGGFGGLLRL---TPDD-VLYCCLPLYH 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 299 ------CLGSVagtmmcLMYGATLILAsPIFNGKKALEAISRERGtflygtpTMFVDI-------LNQPDfSSYD----I 361
Cdd:PRK08279 252 ntggtvAWSSV------LAAGATLALR-RKFSASRFWDDVRRYRA-------TAFQYIgelcrylLNQPP-KPTDrdhrL 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 362 STMCGgviAGspAPPELIRAIINKINMKDLVVAYGTTEnSPVTFAHFpedtvEQKAESVGRI-----MPH--------TE 428
Cdd:PRK08279 317 RLMIG---NG--LRPDIWDEFQQRFGIPRILEFYAASE-GNVGFINV-----FNFDGTVGRVplwlaHPYaivkydvdTG 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 429 ARIMNmEAG--TLAKLNTPGELcirgycvmLG-------YWG--EPQKTEEAV------DQDKWYWTGDVATMNEQGFCK 491
Cdd:PRK08279 386 EPVRD-ADGrcIKVKPGEVGLL--------IGritdrgpFDGytDPEASEKKIlrdvfkKGDAWFNTGDLMRDDGFGHAQ 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 492 IVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVK----DDRMGeeiCACIRLKDGEETTVEEIKAFCKGKISHF 567
Cdd:PRK08279 457 FVDRLGDTFRWKGENVATTEVENALSGFPGVEEAVVYGVEvpgtDGRAG---MAAIVLADGAEFDLAALAAHLYERLPAY 533
|
570 580
....*....|....*....|....*...
gi 572879274 568 KIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:PRK08279 534 AVPLFVRLVPELETTGTFKYRKVDLRKE 561
|
|
| PRK09029 |
PRK09029 |
O-succinylbenzoic acid--CoA ligase; Provisional |
82-581 |
2.23e-18 |
|
O-succinylbenzoic acid--CoA ligase; Provisional
Pssm-ID: 236363 [Multi-domain] Cd Length: 458 Bit Score: 88.00 E-value: 2.23e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 82 AQRVPEREALVVLHEdvRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQameleyvlkkvgCKA 161
Cdd:PRK09029 13 AQVRPQAIALRLNDE--VLTWQQLCARIDQLAAGFAQQGVVEGSGVALRGKNSPETLLAYLALLQ------------CGA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 162 LVFP--KQFKTQQyynvLKQICPEVENAQPGALKSQRLPDLTTvisvdaplpgTLLLDEVVAAGSTRQHLDQLqynqqfl 239
Cdd:PRK09029 79 RVLPlnPQLPQPL----LEELLPSLTLDFALVLEGENTFSALT----------SLHLQLVEGAHAVAWQPQRL------- 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 240 schdpINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEktpeQLRMILPNPLYHclgsVAGTMMC---LMYGATL 316
Cdd:PRK09029 138 -----ATMTLTSGSTGLPKAAVHTAQAHLASAEGVLSLMPFTA----QDSWLLSLPLFH----VSGQGIVwrwLYAGATL 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 317 ILaspifngkkaleaisRERGTF---LYGT------PTMFVDILNQPdfsSYDIST---MCGGviagSPAPPELIRAiin 384
Cdd:PRK09029 205 VV---------------RDKQPLeqaLAGCthaslvPTQLWRLLDNR---SEPLSLkavLLGG----AAIPVELTEQ--- 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 385 kinmkdlvvA----------YGTTEnspvtFAhfpeDTVEQK-AES---VGRIMPHTEARIMNmeagtlaklntpGELCI 450
Cdd:PRK09029 260 ---------AeqqgircwcgYGLTE-----MA----STVCAKrADGlagVGSPLPGREVKLVD------------GEIWL 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 451 RGYCVMLGYW--GEPQkteEAVDQDKWYWTGDVATMNeQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVV 528
Cdd:PRK09029 310 RGASLALGYWrqGQLV---PLVNDEGWFATRDRGEWQ-NGELTILGRLDNLFFSGGEGIQPEEIERVINQHPLVQQVFVV 385
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 572879274 529 GVKDDRMGEEICACIRLKDgeETTVEEIKAFCKGKISHFKIPkyivfVTNYPL 581
Cdd:PRK09029 386 PVADAEFGQRPVAVVESDS--EAAVVNLAEWLQDKLARFQQP-----VAYYLL 431
|
|
| FACL_like_1 |
cd05910 |
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ... |
99-530 |
1.09e-16 |
|
Uncharacterized subfamily of fatty acid CoA ligase (FACL); Fatty acyl-CoA ligases catalyze the ATP-dependent activation of fatty acids in a two-step reaction. The carboxylate substrate first reacts with ATP to form an acyl-adenylate intermediate, which then reacts with CoA to produce an acyl-CoA ester. This is a required step before free fatty acids can participate in most catabolic and anabolic reactions.
Pssm-ID: 341236 [Multi-domain] Cd Length: 457 Bit Score: 82.89 E-value: 1.09e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 99 RLTFAQLKEEVDKAASGLLSIGLCKGDRLgmwgpnsyawVLMQLATAQAMELEYVLKKVGC-KALVFPKQFKTQqyynvL 177
Cdd:cd05910 2 RLSFRELDERSDRIAQGLTAYGIRRGMRA----------VLMVPPGPDFFALTFALFKAGAvPVLIDPGMGRKN-----L 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 178 KQICPEVEnaqpgalksqrlPDLttvisvdapLPGTLLLDEVVAagstrqhldqlqynqqflschdpinIQFTSGTTGSP 257
Cdd:cd05910 67 KQCLQEAE------------PDA---------FIGIPKADEPAA-------------------------ILFTSGSTGTP 100
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 258 KGATLSHYNIVNNSNILGERLKlhektPEQLRMILPN-PLYHCLGSVAG--TMMCLMYGATLILASPifngKKALEAISR 334
Cdd:cd05910 101 KGVVYRHGTFAAQIDALRQLYG-----IRPGEVDLATfPLFALFGPALGltSVIPDMDPTRPARADP----QKLVGAIRQ 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 335 ERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMK-DLVVAYGTTENSPVT-------FA 406
Cdd:cd05910 172 YGVSIVFGSPALLERVARYCAQHGITLPSLRRVLSAGAPVPIALAARLRKMLSDEaEILTPYGATEALPVSsigsrelLA 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 407 HFPEDTVEQKAESVGRIMPHTEARIMNMEAGTLAKLNTP--------GELCIRGYCVMLGYWGEPQKTEEA----VDQDK 474
Cdd:cd05910 252 TTTAATSGGAGTCVGRPIPGVRVRIIEIDDEPIAEWDDTlelprgeiGEITVTGPTVTPTYVNRPVATALAkiddNSEGF 331
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 572879274 475 WYWTGDVATMNEQG---FCkivGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGV 530
Cdd:cd05910 332 WHRMGDLGYLDDEGrlwFC---GRKAHRVITTGGTLYTEPVERVFNTHPGVRRSALVGV 387
|
|
| A_NRPS_acs4 |
cd17654 |
acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal ... |
168-592 |
1.62e-16 |
|
acyl-CoA synthetase family member 4; This family of the adenylation (A) domain of nonribosomal peptide synthases (NRPS) contains acyl-CoA synthethase family member 4, also known as 2-aminoadipic 6-semialdehyde dehydrogenase or aminoadipate-semialdehyde dehydrogenase, most of which are uncharacterized. Acyl-CoA synthetase catalyzes the initial reaction in fatty acid metabolism, by forming a thioester with CoA. NRPSs are large multifunctional enzymes which synthesize many therapeutically useful peptides in bacteria and fungi via a template-directed, nucleic acid independent nonribosomal mechanism. These natural products include antibiotics, immunosuppressants, plant and animal toxins, and enzyme inhibitors. NRPS has a distinct modular structure in which each module is responsible for the recognition, activation, and in some cases, modification of a single amino acid residue of the final peptide product. The modules can be subdivided into domains that catalyze specific biochemical reactions.
Pssm-ID: 341309 [Multi-domain] Cd Length: 449 Bit Score: 82.13 E-value: 1.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 168 FKTQQYYNVLKQICPEVENAQPgaLKSQRLPDLTTVI-------SVDAPLPGTLLLDEVVAAGSTRqHLDQLQYN----Q 236
Cdd:cd17654 24 EKISNLSNFLRKKFQTEERAIG--LRCDRGTESPVAIlailflgAAYAPIDPASPEQRSLTVMKKC-HVSYLLQNkeldN 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 237 QFLSCHDP------------INIQFTSGTTGSPKGATLSHYNIVNnsNILGERLKLhEKTPEQLRmILPNPLyHCLGSVA 304
Cdd:cd17654 101 APLSFTPEhrhfnirtdeclAYVIHTSGTTGTPKIVAVPHKCILP--NIQHFRSLF-NITSEDIL-FLTSPL-TFDPSVV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 305 GTMMCLMYGATLI---LASPIFNGKKALEAISRERGTFLYGTPTMFVDILNQ--PDFSSYDISTMCGGVIAGSPAPPELI 379
Cdd:cd17654 176 EIFLSLSSGATLLivpTSVKVLPSKLADILFKRHRITVLQATPTLFRRFGSQsiKSTVLSATSSLRVLALGGEPFPSLVI 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 380 -RAIINKINMKDLVVAYGTTENSpvTFAHFPEDTVEQKAESVGrimphTEARIMNMEAGTLAKLNTPGELCIRGY---CV 455
Cdd:cd17654 256 lSSWRGKGNRTRIFNIYGITEVS--CWALAYKVPEEDSPVQLG-----SPLLGTVIEVRDQNGSEGTGQVFLGGLnrvCI 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 456 MLGYWGEPQKTeeavdqdkWYWTGDVATMnEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRm 535
Cdd:cd17654 329 LDDEVTVPKGT--------MRATGDFVTV-KDGELFFLGRKDSQIKRRGKRINLDLIQQVIESCLGVESCAVTLSDQQR- 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*..
gi 572879274 536 geeICACIRlkdGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKL 592
Cdd:cd17654 399 ---LIAFIV---GESSSSRIHKELQLTLLSSHAIPDTFVQIDKLPLTSHGKVDKSEL 449
|
|
| PLN02430 |
PLN02430 |
long-chain-fatty-acid-CoA ligase |
101-529 |
2.62e-16 |
|
long-chain-fatty-acid-CoA ligase
Pssm-ID: 178049 [Multi-domain] Cd Length: 660 Bit Score: 82.56 E-value: 2.62e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 101 TFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVL-MQLATAQAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQ 179
Cdd:PLN02430 78 TYKEVYEEVLQIGSALRASGAEPGSRVGIYGSNCPQWIVaMEACAAHSLICVPLYDTLGPGAVDYIVDHAEIDFVFVQDK 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 180 ICPEVENaqPGALKSQRLPDLTTVISVDAPLPgTLLLDEVVAAGSTRQHLDQLQYNQQFLSCHDPIN---IQFTSGTTGS 256
Cdd:PLN02430 158 KIKELLE--PDCKSAKRLKAIVSFTSVTEEES-DKASQIGVKTYSWIDFLHMGKENPSETNPPKPLDictIMYTSGTSGD 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 257 PKGATLSHYN---IVNNSNILGERLKLHEKTPEQLRMILPnpLYHCL---------------GSVAGTMMCLM-----YG 313
Cdd:PLN02430 235 PKGVVLTHEAvatFVRGVDLFMEQFEDKMTHDDVYLSFLP--LAHILdrmieeyffrkgasvGYYHGDLNALRddlmeLK 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 314 ATLILASP-----IFNG-KKALEAIS-RERGTF--LY-------------GTPTMFVDILnqpdfSSYDISTMCGG---- 367
Cdd:PLN02430 313 PTLLAGVPrvferIHEGiQKALQELNpRRRLIFnaLYkyklawmnrgyshKKASPMADFL-----AFRKVKAKLGGrlrl 387
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 368 -VIAGSPAPPElIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTVeqKAESVGRIMPHTEARIMNMEAGTLAKLNTP- 445
Cdd:PLN02430 388 lISGGAPLSTE-IEEFLRVTSCAFVVQGYGLTETLGPTTLGFPDEMC--MLGTVGAPAVYNELRLEEVPEMGYDPLGEPp 464
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 446 -GELCIRGYCVMLGYWGEPQKTEEAVdQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRGGENIYPAELEDFFHTHPKVQ 523
Cdd:PLN02430 465 rGEICVRGKCLFSGYYKNPELTEEVM-KDGWFHTGDIGEILPNGVLKIIDRKKNLIkLSQGEYVALEYLENVYGQNPIVE 543
|
....*.
gi 572879274 524 EVQVVG 529
Cdd:PLN02430 544 DIWVYG 549
|
|
| PRK12582 |
PRK12582 |
acyl-CoA synthetase; Provisional |
82-483 |
2.78e-16 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 237144 [Multi-domain] Cd Length: 624 Bit Score: 82.40 E-value: 2.78e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 82 AQRVPEREALVvlhedvRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQA------MELEYVLK 155
Cdd:PRK12582 69 AQREPGHGQWR------KVTYGEAKRAVDALAQALLDLGLDPGRPVMILSGNSIEHALMTLAAMQAgvpaapVSPAYSLM 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 156 KVGCKalvfpkqfKTQQYYNVLKqicPEVENAQPGAL--KSQRLPDLT--TVISVDAPLPG--TLLLDEVVAAGSTrqhl 229
Cdd:PRK12582 143 SHDHA--------KLKHLFDLVK---PRVVFAQSGAPfaRALAALDLLdvTVVHVTGPGEGiaSIAFADLAATPPT---- 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 230 DQLQYNQQFLSCHDPINIQFTSGTTGSPKGATLSHYNIVnnSNILGerlklhektPEQLRMILPN----------PLYHC 299
Cdd:PRK12582 208 AAVAAAIAAITPDTVAKYLFTSGSTGMPKAVINTQRMMC--ANIAM---------QEQLRPREPDppppvsldwmPWNHT 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 300 LGSVAGTMMCLMYGATLIlaspIFNGK----------KALEAISRergTFLYGTP---TMFVDILNQPD------FSsyD 360
Cdd:PRK12582 277 MGGNANFNGLLWGGGTLY----IDDGKplpgmfeetiRNLREISP---TVYGNVPagyAMLAEAMEKDDalrrsfFK--N 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 361 ISTMCGGviaGSPAPPELIRaiinkiNMKDLVVA-----------YGTTENSPVT-FAHFPedtveqkAESVGRI---MP 425
Cdd:PRK12582 348 LRLMAYG---GATLSDDLYE------RMQALAVRttghripfytgYGATETAPTTtGTHWD-------TERVGLIglpLP 411
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 572879274 426 HTEARimnmeagtLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVAT 483
Cdd:PRK12582 412 GVELK--------LAPVGDKYEVRVKGPNVTPGYHKDPELTAAAFDEEGFYRLGDAAR 461
|
|
| PRK00174 |
PRK00174 |
acetyl-CoA synthetase; Provisional |
416-587 |
1.15e-15 |
|
acetyl-CoA synthetase; Provisional
Pssm-ID: 234677 [Multi-domain] Cd Length: 637 Bit Score: 80.18 E-value: 1.15e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 416 KAESVGRIMPHTEARIMNmEAGTLAKLNTPGELCIR----GycVMLGYWGEPQKTEEAvdqdkwYW--------TGDVAT 483
Cdd:PRK00174 422 KPGSATRPLPGIQPAVVD-EEGNPLEGGEGGNLVIKdpwpG--MMRTIYGDHERFVKT------YFstfkgmyfTGDGAR 492
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 484 MNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVE---EIKAFC 560
Cdd:PRK00174 493 RDEDGYYWITGRVDDVLNVSGHRLGTAEIESALVAHPKVAEAAVVGRPDDIKGQGIYAFVTLKGGEEPSDElrkELRNWV 572
|
170 180
....*....|....*....|....*..
gi 572879274 561 KGKISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:PRK00174 573 RKEIGPIAKPDVIQFAPGLPKTRSGKI 599
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
247-597 |
1.87e-15 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 80.60 E-value: 1.87e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 247 IQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLRMILPnpLYHCLGSVAGTMMCLMYGATLILASP-IFNG 325
Cdd:PRK05691 171 LQYTSGSTALPKGVQVSHGNLVANEQLIRHGFGIDLNPDDVIVSWLP--LYHDMGLIGGLLQPIFSGVPCVLMSPaYFLE 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 326 K--KALEAISRERGTflygtptmfvdILNQPDF--------------SSYDIStmcGGVIAGSPAPP---ELIRAIINKI 386
Cdd:PRK05691 249 RplRWLEAISEYGGT-----------ISGGPDFayrlcservsesalERLDLS---RWRVAYSGSEPirqDSLERFAEKF 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 387 -----NMKDLVVAYGTTENS---------------PVTFAHFPEDTVEQKAESV----GRIMPHTEARIMNMEAGTLAKL 442
Cdd:PRK05691 315 aacgfDPDSFFASYGLAEATlfvsggrrgqgipalELDAEALARNRAEPGTGSVlmscGRSQPGHAVLIVDPQSLEVLGD 394
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 443 NTPGELCIRGYCVMLGYWGEPQKTEEA-VDQD--KWYWTGDVATMNEqGFCKIVGRSKDMIIRGGENIYPAELEDFFHth 519
Cdd:PRK05691 395 NRVGEIWASGPSIAHGYWRNPEASAKTfVEHDgrTWLRTGDLGFLRD-GELFVTGRLKDMLIVRGHNLYPQDIEKTVE-- 471
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 520 pkvQEVQVV--------GVKDDrmGEE---ICACIRLKDGEETTVEE-IKAFCKGKISHFKIPKYIVFVTN---YPLTIS 584
Cdd:PRK05691 472 ---REVEVVrkgrvaafAVNHQ--GEEgigIAAEISRSVQKILPPQAlIKSIRQAVAEACQEAPSVVLLLNpgaLPKTSS 546
|
410
....*....|...
gi 572879274 585 GKIQKFKLREQME 597
Cdd:PRK05691 547 GKLQRSACRLRLA 559
|
|
| PRK07824 |
PRK07824 |
o-succinylbenzoate--CoA ligase; |
250-595 |
2.04e-15 |
|
o-succinylbenzoate--CoA ligase;
Pssm-ID: 236108 [Multi-domain] Cd Length: 358 Bit Score: 78.16 E-value: 2.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 250 TSGTTGSPKGATLSHYNIVNNSNILGERLKlhekTPEQLRMILPNplYHclgsVAGtMMCLM------YGATLILASPIF 323
Cdd:PRK07824 43 TSGTTGTPKGAMLTAAALTASADATHDRLG----GPGQWLLALPA--HH----IAG-LQVLVrsviagSEPVELDVSAGF 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 324 NGKKALEAISRERGTFLYG--TPTMFVDILNQPDfSSYDISTMCGGVIAGSPAP-PELIRAIINKINmkdLVVAYGTTEN 400
Cdd:PRK07824 112 DPTALPRAVAELGGGRRYTslVPMQLAKALDDPA-ATAALAELDAVLVGGGPAPaPVLDAAAAAGIN---VVRTYGMSET 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 401 SpvtfahfpedtveqkAESV--GRIMPHTEARIMNmeagtlaklntpGELCIRGYCVMLGYWGEPQktEEAVDQDKWYWT 478
Cdd:PRK07824 188 S---------------GGCVydGVPLDGVRVRVED------------GRIALGGPTLAKGYRNPVD--PDPFAEPGWFRT 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 479 GDVATMNEqGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVEEIKA 558
Cdd:PRK07824 239 DDLGALDD-GVLTVLGRADDAISTGGLTVLPQVVEAALATHPAVADCAVFGLPDDRLGQRVVAAVVGDGGPAPTLEALRA 317
|
330 340 350
....*....|....*....|....*....|....*..
gi 572879274 559 FCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:PRK07824 318 HVARTLDRTAAPRELHVVDELPRRGIGKVDRRALVRR 354
|
|
| PRK06334 |
PRK06334 |
long chain fatty acid--[acyl-carrier-protein] ligase; Validated |
247-519 |
2.08e-15 |
|
long chain fatty acid--[acyl-carrier-protein] ligase; Validated
Pssm-ID: 180533 [Multi-domain] Cd Length: 539 Bit Score: 79.09 E-value: 2.08e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 247 IQFTSGTTGSPKGATLSHYNIVNNSNILgerLKLHEKTpEQLRMILPNPLYHCLGSVAGTMMCLMYGATLILASPIFNGK 326
Cdd:PRK06334 188 ILFTSGTEKLPKGVPLTHANLLANQRAC---LKFFSPK-EDDVMMSFLPPFHAYGFNSCTLFPLLSGVPVVFAYNPLYPK 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 327 KALEAISRERGTFLYGTPTMFVDILNQPDFSSYDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFA 406
Cdd:PRK06334 264 KIVEMIDEAKVTFLGSTPVFFDYILKTAKKQESCLPSLRFVVIGGDAFKDSLYQEALKTFPHIQLRQGYGTTECSPVITI 343
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 407 hfpeDTVE--QKAESVGriMPHTEARIMNMEAGTLAKLNT--PGELCIRGYCVMLGYWGE-PQKTEEAVDQDKWYWTGDV 481
Cdd:PRK06334 344 ----NTVNspKHESCVG--MPIRGMDVLIVSEETKVPVSSgeTGLVLTRGTSLFSGYLGEdFGQGFVELGGETWYVTGDL 417
|
250 260 270
....*....|....*....|....*....|....*...
gi 572879274 482 ATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTH 519
Cdd:PRK06334 418 GYVDRHGELFLKGRLSRFVKIGAEMVSLEALESILMEG 455
|
|
| PRK12467 |
PRK12467 |
peptide synthase; Provisional |
229-589 |
3.80e-15 |
|
peptide synthase; Provisional
Pssm-ID: 237108 [Multi-domain] Cd Length: 3956 Bit Score: 79.43 E-value: 3.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 229 LDQlqyNQQFLSCHDPINIQ------------FTSGTTGSPKGATLSHYNIVNNSNILGERLKLH------EKTPeqlrm 290
Cdd:PRK12467 1696 LDQ---EDDWLEGYSDSNPAvnlapqnlayviYTSGSTGRPKGAGNRHGALVNRLCATQEAYQLSaadvvlQFTS----- 1767
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 291 ilpnplYHCLGSVAGTMMCLMYGATLILASPIF--NGKKALEAISRERGTFLYGTPTMFVDILNQPDFSSYDIS---TMC 365
Cdd:PRK12467 1768 ------FAFDVSVWELFWPLINGARLVIAPPGAhrDPEQLIQLIERQQVTTLHFVPSMLQQLLQMDEQVEHPLSlrrVVC 1841
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 366 GgviaGSPAPPELIRAIINKINMKDLVVAYGTTENSpVTFAHFP---EDTVEQKAESVGRIMPHTEARIMNMEAgTLAKL 442
Cdd:PRK12467 1842 G----GEALEVEALRPWLERLPDTGLFNLYGPTETA-VDVTHWTcrrKDLEGRDSVPIGQPIANLSTYILDASL-NPVPI 1915
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 443 NTPGELCIRGYCVMLGYWGEPQKTEEAVDQD-------KWYWTGDVATMNEQGFCKIVGRSKDMI-IRGGEnIYPAELED 514
Cdd:PRK12467 1916 GVAGELYLGGVGLARGYLNRPALTAERFVADpfgtvgsRLYRTGDLARYRADGVIEYLGRIDHQVkIRGFR-IELGEIEA 1994
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 515 FFHTHPKVQEVQVVgVKDDRMGEEICACIRLKDGE--------ETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGK 586
Cdd:PRK12467 1995 RLREQGGVREAVVI-AQDGANGKQLVAYVVPTDPGlvdddeaqVALRAILKNHLKASLPEYMVPAHLVFLARMPLTPNGK 2073
|
...
gi 572879274 587 IQK 589
Cdd:PRK12467 2074 LDR 2076
|
|
| PRK03584 |
PRK03584 |
acetoacetate--CoA ligase; |
83-588 |
5.97e-15 |
|
acetoacetate--CoA ligase;
Pssm-ID: 235134 [Multi-domain] Cd Length: 655 Bit Score: 77.91 E-value: 5.97e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 83 QRVPEREALVVLHED---VRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATA----------QAME 149
Cdd:PRK03584 95 HRRDDRPAIIFRGEDgprRELSWAELRRQVAALAAALRALGVGPGDRVAAYLPNIPETVVAMLATAslgaiwsscsPDFG 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 150 LEYVLKKVGckalvfpkqfktqqyynvlkQICPEVENAQPG---------------ALKSQrLPDLTTVISVD------- 207
Cdd:PRK03584 175 VQGVLDRFG--------------------QIEPKVLIAVDGyryggkafdrrakvaELRAA-LPSLEHVVVVPylgpaaa 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 208 -APLPGTLLLDEVVAAGSTrqhlDQLQYNQqfLSCHDPINIQFTSGTTGSPKGATLSHynivnnSNILGERLKLHektpe 286
Cdd:PRK03584 234 aAALPGALLWEDFLAPAEA----AELEFEP--VPFDHPLWILYSSGTTGLPKCIVHGH------GGILLEHLKEL----- 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 287 QLrmilpnplyHC-LG--------SVAGTMM------CLMYGATLIL--ASPIFNGKKAL-EAISRERGTFLyGTPTMFV 348
Cdd:PRK03584 297 GL---------HCdLGpgdrffwyTTCGWMMwnwlvsGLLVGATLVLydGSPFYPDPNVLwDLAAEEGVTVF-GTSAKYL 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 349 DILNQPDFS---SYDISTMCGGVIAGSPAPPELIRAIINKINmKDLVVAY---GT---------TENSPVTfahfpedtv 413
Cdd:PRK03584 367 DACEKAGLVpgeTHDLSALRTIGSTGSPLPPEGFDWVYEHVK-ADVWLASisgGTdicscfvggNPLLPVY--------- 436
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 414 eqkaesVGRIMphteARIMNM------EAGtlaklnTP-----GEL-CIRGYCVM-LGYWGEP--QKTEEAvdqdkwYWT 478
Cdd:PRK03584 437 ------RGEIQ----CRGLGMaveawdEDG------RPvvgevGELvCTKPFPSMpLGFWNDPdgSRYRDA------YFD 494
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 479 --------GDVATMNEQGFCKIVGRSKDMIIRGGENIYPAEL----EDFfhthPKVQEVQVVGVKDDRMGEEICACIRLK 546
Cdd:PRK03584 495 tfpgvwrhGDWIEITEHGGVVIYGRSDATLNRGGVRIGTAEIyrqvEAL----PEVLDSLVIGQEWPDGDVRMPLFVVLA 570
|
570 580 590 600
....*....|....*....|....*....|....*....|....*..
gi 572879274 547 DGEETT---VEEIKAFCKGKIS--HfkIPKYIVFVTNYPLTISGKIQ 588
Cdd:PRK03584 571 EGVTLDdalRARIRTTIRTNLSprH--VPDKIIAVPDIPRTLSGKKV 615
|
|
| PLN02736 |
PLN02736 |
long-chain acyl-CoA synthetase |
100-516 |
6.64e-15 |
|
long-chain acyl-CoA synthetase
Pssm-ID: 178337 [Multi-domain] Cd Length: 651 Bit Score: 77.83 E-value: 6.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 100 LTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLA-TAQAM------------ELEYVLKKVGCKALvfpk 166
Cdd:PLN02736 79 MTYGEAGTARTAIGSGLVQHGIPKGACVGLYFINRPEWLIVDHAcSAYSYvsvplydtlgpdAVKFIVNHAEVAAI---- 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 167 qFKTQQYYNVLKQICPEvenaqpgaLKSQRLpdLTTVISVDAPLPGT--------LLLDEVVAAGSTRQhldqlqynQQF 238
Cdd:PLN02736 155 -FCVPQTLNTLLSCLSE--------IPSVRL--IVVVGGADEPLPSLpsgtgveiVTYSKLLAQGRSSP--------QPF 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 239 LSC--HDPINIQFTSGTTGSPKGATLSHYNIVnnSNILGERLKLHektpeqlrmILPN-------PLYHCLGSVaGTMMC 309
Cdd:PLN02736 216 RPPkpEDVATICYTSGTTGTPKGVVLTHGNLI--ANVAGSSLSTK---------FYPSdvhisylPLAHIYERV-NQIVM 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 310 LMYGAtlilASPIFNGK--KALEAISRERGTFLYGTPTMFVDIlnqpdfssYDISTMC----GGV--------------- 368
Cdd:PLN02736 284 LHYGV----AVGFYQGDnlKLMDDLAALRPTIFCSVPRLYNRI--------YDGITNAvkesGGLkerlfnaaynakkqa 351
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 369 -IAGSPAPPELIRAIINKIN---------------------MKDLVV--------AYGTTENSPVTFAHFPEDTVeqkAE 418
Cdd:PLN02736 352 lENGKNPSPMWDRLVFNKIKaklggrvrfmssgasplspdvMEFLRIcfggrvleGYGMTETSCVISGMDEGDNL---SG 428
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 419 SVGRIMPHTEARIMN---MEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGR 495
Cdd:PLN02736 429 HVGSPNPACEVKLVDvpeMNYTSEDQPYPRGEICVRGPIIFKGYYKDEVQTREVIDEDGWLHTGDIGLWLPGGRLKIIDR 508
|
490 500
....*....|....*....|..
gi 572879274 496 SKDMI-IRGGENIYPAELEDFF 516
Cdd:PLN02736 509 KKNIFkLAQGEYIAPEKIENVY 530
|
|
| hsFATP2a_ACSVL_like |
cd05938 |
Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar ... |
96-550 |
1.17e-14 |
|
Fatty acid transport proteins (FATP) including hsFATP2, hsFATP5, and hsFATP6, and similar proteins; Fatty acid transport proteins (FATP) of this family transport long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes hsFATP2, hsFATP5, and hsFATP6, and similar proteins. Each FATP has unique patterns of tissue distribution. These FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. The hsFATP proteins exist in two splice variants; the b variant, lacking exon 3, has no acyl-CoA synthetase activity. FATPs are key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Pssm-ID: 341261 [Multi-domain] Cd Length: 537 Bit Score: 76.95 E-value: 1.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 96 EDVRLTFAQLKEEVDKAASGLLS-IGLCKGDRLGMWGPNSYAWVLMQLATAQ-------------AMELEYVLKKVGCKA 161
Cdd:cd05938 2 EGETYTYRDVDRRSNQAARALLAhAGLRPGDTVALLLGNEPAFLWIWLGLAKlgcpvaflntnirSKSLLHCFRCCGAKV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 162 LVFPKQFKtqqyyNVLKQICPevenaqpgALKSQRLPDLttVISVDAPLPGTL-LLDEVVAA------GSTRQHLdqlqy 234
Cdd:cd05938 82 LVVAPELQ-----EAVEEVLP--------ALRADGVSVW--YLSHTSNTEGVIsLLDKVDAAsdepvpASLRAHV----- 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 235 nqqflSCHDPINIQFTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTpeqlrMILPNPLYHCLGSVAGTMMCLMYGA 314
Cdd:cd05938 142 -----TIKSPALYIYTSGTTGLPKAARISHLRVLQCSGFLSLCGVTADDV-----IYITLPLYHSSGFLLGIGGCIELGA 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 315 TLILAsPIFNGKKALEAISRERGT-FLYGTPTMFVdILNQPDFSSYDISTMcgGVIAGSPAPPELIRAIINKINMKDLVV 393
Cdd:cd05938 212 TCVLK-PKFSASQFWDDCRKHNVTvIQYIGELLRY-LCNQPQSPNDRDHKV--RLAIGNGLRADVWREFLRRFGPIRIRE 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 394 AYGTTENSpVTFAHFPEdtveqKAESVGRimphtearimnmeAGTLAKLNTPGELcIR-------------GYCV----- 455
Cdd:cd05938 288 FYGSTEGN-IGFFNYTG-----KIGAVGR-------------VSYLYKLLFPFEL-IKfdvekeepvrdaqGFCIpvakg 347
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 456 --------------MLGYWGEPQKTEEA----VDQ--DKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDF 515
Cdd:cd05938 348 epgllvakitqqspFLGYAGDKEQTEKKllrdVFKkgDVYFNTGDLLVQDQQNFLYFHDRVGDTFRWKGENVATTEVADV 427
|
490 500 510
....*....|....*....|....*....|....*....
gi 572879274 516 FHTHPKVQEVQVVGVK----DDRMGeeiCACIRLKDGEE 550
Cdd:cd05938 428 LGLLDFLQEVNVYGVTvpghEGRIG---MAAVKLKPGHE 463
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
191-589 |
1.19e-14 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 77.90 E-value: 1.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 191 ALKSQRLPDLTT-------VISVDAPLPGTLLLDEVVAAGSTR-------QHLDQLQYNQQFLSCHDPIN-IQFTSGTTG 255
Cdd:PRK05691 3803 GLPAQRLQRIIElsrtpvlVCSAACREQARALLDELGCANRPRllvweevQAGEVASHNPGIYSGPDNLAyVIYTSGSTG 3882
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 256 SPKGATLSHYNIVNNSNILGERLKLHE-----KTPEQLRMIlpnplyhclgSVAGTMMCLMYGATL-ILASPIFNGKKAL 329
Cdd:PRK05691 3883 LPKGVMVEQRGMLNNQLSKVPYLALSEadviaQTASQSFDI----------SVWQFLAAPLFGARVeIVPNAIAHDPQGL 3952
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 330 EAISRERG-TFLYGTPTMFVDILNQPDFSSYDISTMcggVIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPvTFAHF 408
Cdd:PRK05691 3953 LAHVQAQGiTVLESVPSLIQGMLAEDRQALDGLRWM---LPTGEAMPPELARQWLQRYPQIGLVNAYGPAECSD-DVAFF 4028
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 409 PEDTVEQKAESVGRIMPHTEARIMNM-EAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEEA-------VDQDKWYWTGD 480
Cdd:PRK05691 4029 RVDLASTRGSYLPIGSPTDNNRLYLLdEALELVPLGAVGELCVAGTGVGRGYVGDPLRTALAfvphpfgAPGERLYRTGD 4108
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 481 VATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVqVVGVKDDRMGEEICACIRLKDGEETT---VEEIK 557
Cdd:PRK05691 4109 LARRRSDGVLEYVGRIDHQVKIRGYRIELGEIEARLHEQAEVREA-AVAVQEGVNGKHLVGYLVPHQTVLAQgalLERIK 4187
|
410 420 430
....*....|....*....|....*....|..
gi 572879274 558 AFCKGKISHFKIPKYIVFVTNYPLTISGKIQK 589
Cdd:PRK05691 4188 QRLRAELPDYMVPLHWLWLDRLPLNANGKLDR 4219
|
|
| entF |
PRK10252 |
enterobactin non-ribosomal peptide synthetase EntF; |
73-587 |
7.65e-14 |
|
enterobactin non-ribosomal peptide synthetase EntF;
Pssm-ID: 236668 [Multi-domain] Cd Length: 1296 Bit Score: 75.08 E-value: 7.65e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 73 TVGQCLETTAQRVPEREALVvlHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAmeley 152
Cdd:PRK10252 459 TLSALVAQQAAKTPDAPALA--DARYQFSYREMREQVVALANLLRERGVKPGDSVAVALPRSVFLTLALHAIVEA----- 531
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 153 vlkkvgcKALVFPkqFKTQQYYNVLKQIcpeVENAQPGALKSQ-----RLPDL--TTVISVDAPLPgtllldevvAAGST 225
Cdd:PRK10252 532 -------GAAWLP--LDTGYPDDRLKMM---LEDARPSLLITTadqlpRFADVpdLTSLCYNAPLA---------PQGAA 590
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 226 RQHLDQlqynqqflsCHDPINIQFTSGTTGSPKGATLSHYNIVN------NSNILGERLKLHEKTPEQLRMilpnplyhc 299
Cdd:PRK10252 591 PLQLSQ---------PHHTAYIIFTSGSTGRPKGVMVGQTAIVNrllwmqNHYPLTADDVVLQKTPCSFDV--------- 652
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 300 lgSVAGTMMCLMYGATLILASPifNGKK---ALEA-ISRERGTFLYGTPTMFVDILNQPDFSSYDISTM------Cggvi 369
Cdd:PRK10252 653 --SVWEFFWPFIAGAKLVMAEP--EAHRdplAMQQfFAEYGVTTTHFVPSMLAAFVASLTPEGARQSCAslrqvfC---- 724
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 370 AGSPAPPELIRAIINKINMKdLVVAYGTTENS-PVT-FAHFPEDTVEQKAESV--GRIMPHTEARIMNmeagtlAKLN-- 443
Cdd:PRK10252 725 SGEALPADLCREWQQLTGAP-LHNLYGPTEAAvDVSwYPAFGEELAAVRGSSVpiGYPVWNTGLRILD------ARMRpv 797
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 444 ---TPGELCIRGYCVMLGYWGEPQKTEE------AVDQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRgGENIYPAELE 513
Cdd:PRK10252 798 ppgVAGDLYLTGIQLAQGYLGRPDLTASrfiadpFAPGERMYRTGDVARWLDDGAVEYLGRSDDQLkIR-GQRIELGEID 876
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 514 DFFHTHPKVQEV----QVVGVKDDRMGEE--ICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:PRK10252 877 RAMQALPDVEQAvthaCVINQAAATGGDArqLVGYLVSQSGLPLDTSALQAQLRERLPPHMVPVVLLQLDQLPLSANGKL 956
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
249-594 |
8.65e-14 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 75.20 E-value: 8.65e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 249 FTSGTTGSPKGATLSHynivnnsNILGERLK-------------LHEKTPEQLRMilpnplyhclgSVAGTMMCLMYGAT 315
Cdd:PRK05691 1280 YTSGSTGQPKGVGNTH-------AALAERLQwmqatyalddsdvLMQKAPISFDV-----------SVWECFWPLITGCR 1341
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 316 LILASPifnGK-----KALEAISRERGTFLYGTPTMFVDILNQPDfssydiSTMCGG---VIAGSPA-PPELIRAIINKI 386
Cdd:PRK05691 1342 LVLAGP---GEhrdpqRIAELVQQYGVTTLHFVPPLLQLFIDEPL------AAACTSlrrLFSGGEAlPAELRNRVLQRL 1412
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 387 NMKDLVVAYGTTENS-PVTFAHFPEDTVEQkaESVGRIMPHTEARIMNMEAgTLAKLNTPGELCIRGYCVMLGYWGEPQK 465
Cdd:PRK05691 1413 PQVQLHNRYGPTETAiNVTHWQCQAEDGER--SPIGRPLGNVLCRVLDAEL-NLLPPGVAGELCIGGAGLARGYLGRPAL 1489
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 466 TEE-------AVDQDKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVgVKDDRMGEE 538
Cdd:PRK05691 1490 TAErfvpdplGEDGARLYRTGDRARWNADGALEYLGRLDQQVKLRGFRVEPEEIQARLLAQPGVAQAAVL-VREGAAGAQ 1568
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 572879274 539 ICACIRLKDGEETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLRE 594
Cdd:PRK05691 1569 LVGYYTGEAGQEAEAERLKAALAAELPEYMVPAQLIRLDQMPLGPSGKLDRRALPE 1624
|
|
| PRK08180 |
PRK08180 |
feruloyl-CoA synthase; Reviewed |
73-480 |
8.70e-14 |
|
feruloyl-CoA synthase; Reviewed
Pssm-ID: 236175 [Multi-domain] Cd Length: 614 Bit Score: 74.14 E-value: 8.70e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 73 TVGQCLETTAQRVPEREALV---VLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLAtaqAM- 148
Cdd:PRK08180 40 RLTDRLVHWAQEAPDRVFLAergADGGWRRLTYAEALERVRAIAQALLDRGLSAERPLMILSGNSIEHALLALA---AMy 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 149 --------------------ELEYVLKKVGcKALVFpkqfktqqyynvlkqicpeVENAQP--GALKSQRLPDlTTVISV 206
Cdd:PRK08180 117 agvpyapvspayslvsqdfgKLRHVLELLT-PGLVF-------------------ADDGAAfaRALAAVVPAD-VEVVAV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 207 DAPLPG--TLLLDEVVAAGSTRQhLDQLqynqqflscHDPIN------IQFTSGTTGSPKGATLSHYNIVNNSNILGERL 278
Cdd:PRK08180 176 RGAVPGraATPFAALLATPPTAA-VDAA---------HAAVGpdtiakFLFTSGSTGLPKAVINTHRMLCANQQMLAQTF 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 279 KLHEKTPEQLRMILP-NplyHCLGSVAGTMMCLMYGATLIlaspIFNGK----------KALEAISrerGTFLYGTPT-- 345
Cdd:PRK08180 246 PFLAEEPPVLVDWLPwN---HTFGGNHNLGIVLYNGGTLY----IDDGKptpggfdetlRNLREIS---PTVYFNVPKgw 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 346 -MFVDILNQPD------FSSYDIsTMCGGviAGSPAP-----PEL-IRAIINKINMkdlVVAYGTTENSPV-TFAHFPED 411
Cdd:PRK08180 316 eMLVPALERDAalrrrfFSRLKL-LFYAG--AALSQDvwdrlDRVaEATCGERIRM---MTGLGMTETAPSaTFTTGPLS 389
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 572879274 412 tveqKAESVGRIMPHTEARimnmeagtLAKLNTPGELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGD 480
Cdd:PRK08180 390 ----RAGNIGLPAPGCEVK--------LVPVGGKLEVRVKGPNVTPGYWRAPELTAEAFDEEGYYRSGD 446
|
|
| PRK05850 |
PRK05850 |
acyl-CoA synthetase; Validated |
201-587 |
1.18e-13 |
|
acyl-CoA synthetase; Validated
Pssm-ID: 235624 [Multi-domain] Cd Length: 578 Bit Score: 73.82 E-value: 1.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 201 TTVISVDaplpgTLLLDEVVAAGSTRQHLDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYN-IVNNSNILGERLK 279
Cdd:PRK05850 136 PPVIEVD-----LLDLDSPRGSDARPRDLPSTAY------------LQYTSGSTRTPAGVMVSHRNvIANFEQLMSDYFG 198
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 280 LHEKTPEQLRMI---LPnpLYHCLGSVAGTMMCLMYGATLILASPI-FNGKKA--LEAISRERGTFLYGTPTMF---VDI 350
Cdd:PRK05850 199 DTGGVPPPDTTVvswLP--FYHDMGLVLGVCAPILGGCPAVLTSPVaFLQRPArwMQLLASNPHAFSAAPNFAFelaVRK 276
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 351 LNQPDFSSYDISTMCGgVIAGS----PAPpelIRAIIN---KINMKDLVV--AYGTTE----------NSPVTFAHF-PE 410
Cdd:PRK05850 277 TSDDDMAGLDLGGVLG-IISGServhPAT---LKRFADrfaPFNLRETAIrpSYGLAEatvyvatrepGQPPESVRFdYE 352
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 411 DTVEQKAES---------VGRIMPHTEA-RIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTE-----------EA 469
Cdd:PRK05850 353 KLSAGHAKRcetgggtplVSYGSPRSPTvRIVDPDTCIECPAGTVGEIWVHGDNVAAGYWQKPEETErtfgatlvdpsPG 432
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 470 VDQDKWYWTGDVATMNEQGFCkIVGRSKDMIIRGGENIYPAELEdffhthPKVQE-----VQVVGVKDDRmGEEICACIR 544
Cdd:PRK05850 433 TPEGPWLRTGDLGFISEGELF-IVGRIKDLLIVDGRNHYPDDIE------ATIQEitggrVAAISVPDDG-TEKLVAIIE 504
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 572879274 545 LKDGEETTVEEIKAFC--KGKI------SHFKIPKYIVFVT--NYPLTISGKI 587
Cdd:PRK05850 505 LKKRGDSDEEAMDRLRtvKREVtsaiskSHGLSVADLVLVApgSIPITTSGKI 557
|
|
| PLN02614 |
PLN02614 |
long-chain acyl-CoA synthetase |
101-529 |
1.38e-13 |
|
long-chain acyl-CoA synthetase
Pssm-ID: 166255 [Multi-domain] Cd Length: 666 Bit Score: 73.90 E-value: 1.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 101 TFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVL-MQLATAQAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQ 179
Cdd:PLN02614 81 TYQEVYDIVIKLGNSLRSVGVKDEAKCGIYGANSPEWIIsMEACNAHGLYCVPLYDTLGAGAVEFIISHSEVSIVFVEEK 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 180 ICPEVENAQPGALKSQRlpdltTVISV---------DAPLPGTLL--LDEVVAAGSTRQhldqlqYNQQFLSCHDPINIQ 248
Cdd:PLN02614 161 KISELFKTCPNSTEYMK-----TVVSFggvsreqkeEAETFGLVIyaWDEFLKLGEGKQ------YDLPIKKKSDICTIM 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 249 FTSGTTGSPKGATLSHYNIVNNSNILGERLK-LHEKTPEQLRMILPNPLYHC---------------------------- 299
Cdd:PLN02614 230 YTSGTTGDPKGVMISNESIVTLIAGVIRLLKsANAALTVKDVYLSYLPLAHIfdrvieecfiqhgaaigfwrgdvkllie 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 300 -LGSVAGTMMC--------LMYGATLILASPIFNGKKALE-AISRERGTFLYGTPtmfvDILNQPDFSSYDISTMCGG-- 367
Cdd:PLN02614 310 dLGELKPTIFCavprvldrVYSGLQKKLSDGGFLKKFVFDsAFSYKFGNMKKGQS----HVEASPLCDKLVFNKVKQGlg 385
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 368 -----VIAGSPAPPELIRAIINKINMKDLVVAYGTTENSPVTFAHFPEDTveQKAESVGRIMPHTEARIMN---MEAGTL 439
Cdd:PLN02614 386 gnvriILSGAAPLASHVESFLRVVACCHVLQGYGLTESCAGTFVSLPDEL--DMLGTVGPPVPNVDIRLESvpeMEYDAL 463
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 440 AklNTP-GELCIRGYCVMLGYWGEPQKTEEaVDQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRGGENIYPAELEDFFH 517
Cdd:PLN02614 464 A--STPrGEICIRGKTLFSGYYKREDLTKE-VLIDGWLHTGDVGEWQPNGSMKIIDRKKNIFkLSQGEYVAVENIENIYG 540
|
490
....*....|..
gi 572879274 518 THPKVQEVQVVG 529
Cdd:PLN02614 541 EVQAVDSVWVYG 552
|
|
| PLN02861 |
PLN02861 |
long-chain-fatty-acid-CoA ligase |
60-529 |
5.75e-13 |
|
long-chain-fatty-acid-CoA ligase
Pssm-ID: 178452 [Multi-domain] Cd Length: 660 Bit Score: 71.80 E-value: 5.75e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 60 YVQGCTKKHLNSKTVGQCLETTAQRVPErealvvlhedVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVL 139
Cdd:PLN02861 48 FFSDAVKKYPNNQMLGRRQVTDSKVGPY----------VWLTYKEVYDAAIRIGSAIRSRGVNPGDRCGIYGSNCPEWII 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 140 -MQLATAQAMELEYVLKKVGCKALVFPKQFKTQQYYNVLKQICPEVENAQPGA---LKS-QRLPDLTTVISVDAPLPGTL 214
Cdd:PLN02861 118 aMEACNSQGITYVPLYDTLGANAVEFIINHAEVSIAFVQESKISSILSCLPKCssnLKTiVSFGDVSSEQKEEAEELGVS 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 215 LL--DEVVAAGSTRQHLDQLQYNqqflschDPINIQFTSGTTGSPKGAtlshynIVNNSNILGERLKLHEKTPEQLRMIL 292
Cdd:PLN02861 198 CFswEEFSLMGSLDCELPPKQKT-------DICTIMYTSGTTGEPKGV------ILTNRAIIAEVLSTDHLLKVTDRVAT 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 293 PN-------PLYHCLGSVAGTMmCLMYGATLilasPIFNG--KKALEAISRERGTFLYGTPTMFVDI---LNQP------ 354
Cdd:PLN02861 265 EEdsyfsylPLAHVYDQVIETY-CISKGASI----GFWQGdiRYLMEDVQALKPTIFCGVPRVYDRIytgIMQKissggm 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 355 ------DFS-SYDISTMCGGvIAGSPAPPELIRAIINKI-----------------------------NMKDLVVAYGTT 398
Cdd:PLN02861 340 lrkklfDFAyNYKLGNLRKG-LKQEEASPRLDRLVFDKIkeglggrvrlllsgaaplprhveeflrvtSCSVLSQGYGLT 418
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 399 ENSPVTFAHFPEdtVEQKAESVGRIMPHTEARIMNM-EAGTLAKLNTP-GELCIRGYCVMLGYWGEPQKTEEAVdQDKWY 476
Cdd:PLN02861 419 ESCGGCFTSIAN--VFSMVGTVGVPMTTIEARLESVpEMGYDALSDVPrGEICLRGNTLFSGYHKRQDLTEEVL-IDGWF 495
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....
gi 572879274 477 WTGDVATMNEQGFCKIVGRSKDMI-IRGGENIYPAELEDFFHTHPKVQEVQVVG 529
Cdd:PLN02861 496 HTGDIGEWQPNGAMKIIDRKKNIFkLSQGEYVAVENLENTYSRCPLIASIWVYG 549
|
|
| PLN02387 |
PLN02387 |
long-chain-fatty-acid-CoA ligase family protein |
92-527 |
6.68e-13 |
|
long-chain-fatty-acid-CoA ligase family protein
Pssm-ID: 215217 [Multi-domain] Cd Length: 696 Bit Score: 71.69 E-value: 6.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 92 VVLHEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVL-MQLATAQAMELEYVLKKVGCKALVFPKQfKT 170
Cdd:PLN02387 99 LHLGEYEWITYGQVFERVCNFASGLVALGHNKEERVAIFADTRAEWLIaLQGCFRQNITVVTIYASLGEEALCHSLN-ET 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 171 QqyynVLKQICPEVENAQPGALkSQRLPDLTTVI-----SVDAPLPGTLLLDEVVAAGSTRQHLDQLQYNQQFL-SCHDP 244
Cdd:PLN02387 178 E----VTTVICDSKQLKKLIDI-SSQLETVKRVIymddeGVDSDSSLSGSSNWTVSSFSEVEKLGKENPVDPDLpSPNDI 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 245 INIQFTSGTTGSPKGATLSHYNIVnnsnilgerlklheKTPEQLRMILPN-----------PLYHCLGSVAGTMMC---- 309
Cdd:PLN02387 253 AVIMYTSGSTGLPKGVMMTHGNIV--------------ATVAGVMTVVPKlgkndvylaylPLAHILELAAESVMAavga 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 310 -LMYGATLIL---ASPIFNGKK------------ALEAI-SRER------------------------------GTFL-- 340
Cdd:PLN02387 319 aIGYGSPLTLtdtSNKIKKGTKgdasalkptlmtAVPAIlDRVRdgvrkkvdakgglakklfdiaykrrlaaieGSWFga 398
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 341 YGTPTMFVDILNqpdFSSydISTMCGGVI-----AGSPAPPELIRaIINkINMKDLVV-AYGTTEN-SPVTFAHFpEDTv 413
Cdd:PLN02387 399 WGLEKLLWDALV---FKK--IRAVLGGRIrfmlsGGAPLSGDTQR-FIN-ICLGAPIGqGYGLTETcAGATFSEW-DDT- 469
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 414 eqkaeSVGRI---MPHTEARIMNMEAGTLAKLNTP---GELCIRGYCVMLGYWGEPQKTEEA--VDQD--KWYWTGDVAT 483
Cdd:PLN02387 470 -----SVGRVgppLPCCYVKLVSWEEGGYLISDKPmprGEIVIGGPSVTLGYFKNQEKTDEVykVDERgmRWFYTGDIGQ 544
|
490 500 510 520
....*....|....*....|....*....|....*....|....*
gi 572879274 484 MNEQGFCKIVGRSKDMI-IRGGENIYPAELEDFFHTHPKVQEVQV 527
Cdd:PLN02387 545 FHPDGCLEIIDRKKDIVkLQHGEYVSLGKVEAALSVSPYVDNIMV 589
|
|
| PTZ00342 |
PTZ00342 |
acyl-CoA synthetase; Provisional |
242-507 |
3.81e-12 |
|
acyl-CoA synthetase; Provisional
Pssm-ID: 240370 [Multi-domain] Cd Length: 746 Bit Score: 69.36 E-value: 3.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 242 HDP---INIQFTSGTTGSPKGATLSHYNIVN------NSNIlgeRLKLHEKTpeQLRMIlpnPLYHCLGSVAgTMMCLMY 312
Cdd:PTZ00342 301 EDPdfiTSIVYTSGTSGKPKGVMLSNKNLYNtvvplcKHSI---FKKYNPKT--HLSYL---PISHIYERVI-AYLSFML 371
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 313 GATLILASP---IFNgkkalEAISRERGTFLYGTPTMF--------VDILNQPDFSSYDI--------STMCGG------ 367
Cdd:PTZ00342 372 GGTINIWSKdinYFS-----KDIYNSKGNILAGVPKVFnriytnimTEINNLPPLKRFLVkkilslrkSNNNGGfskfle 446
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 368 ------------------VI--AGSPAPPELIRAIINKINMKdLVVAYGTTENspvTFAHFPEDTVEQKAESVG-RIMPH 426
Cdd:PTZ00342 447 githisskikdkvnpnleVIlnGGGKLSPKIAEELSVLLNVN-YYQGYGLTET---TGPIFVQHADDNNTESIGgPISPN 522
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 427 TEARIMNMEAGTlAKLNTP-GELCIRGYCVMLGYWGEPQKTEEAVDQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRGG 504
Cdd:PTZ00342 523 TKYKVRTWETYK-ATDTLPkGELLIKSDSIFSGYFLEKEQTKNAFTEDGYFKTGDIVQINKNGSLTFLDRSKGLVkLSQG 601
|
...
gi 572879274 505 ENI 507
Cdd:PTZ00342 602 EYI 604
|
|
| FCS |
cd05921 |
Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl ... |
99-482 |
2.21e-11 |
|
Feruloyl-CoA synthetase (FCS); Feruloyl-CoA synthetase is an essential enzyme in the feruloyl acid degradation pathway and enables some proteobacteria to grow on media containing feruloyl acid as the sole carbon source. It catalyzes the transfer of CoA to the carboxyl group of ferulic acid, which then forms feruloyl-CoA in the presence of ATP and Mg2. The resulting feruloyl-CoA is further degraded to vanillin and acetyl-CoA. Feruloyl-CoA synthetase (FCS) is a subfamily of the adenylate-forming enzymes superfamily.
Pssm-ID: 341245 [Multi-domain] Cd Length: 561 Bit Score: 66.69 E-value: 2.21e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 99 RLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLAtAQAMELEYvlkkvgckALVFPKQFKTQQYYNVLK 178
Cdd:cd05921 25 RVTYAEALRQVRAIAQGLLDLGLSAERPLLILSGNSIEHALMALA-AMYAGVPA--------APVSPAYSLMSQDLAKLK 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 179 QICPE-------VENAQP--GALKSQRLPDlTTVISVDAPLPG--TLLLDEVVAA---GSTRQHLDQLQYNQ--QFLsch 242
Cdd:cd05921 96 HLFELlkpglvfAQDAAPfaRALAAIFPLG-TPLVVSRNAVAGrgAISFAELAATpptAAVDAAFAAVGPDTvaKFL--- 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 243 dpiniqFTSGTTGSPKGATLSHYNIVnnSNILGERLKLHEKTPEQLRMILPNPLYHCLGSVAGTMMCLMYGATLIlaspI 322
Cdd:cd05921 172 ------FTSGSTGLPKAVINTQRMLC--ANQAMLEQTYPFFGEEPPVLVDWLPWNHTFGGNHNFNLVLYNGGTLY----I 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 323 FNGKKALEAIS------RERGTFLYGT-P---TMFVDILNQPD------FSsyDISTMcggVIAGSPAPPELIRAIiNKI 386
Cdd:cd05921 240 DDGKPMPGGFEetlrnlREISPTVYFNvPagwEMLVAALEKDEalrrrfFK--RLKLM---FYAGAGLSQDVWDRL-QAL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 387 NMKD------LVVAYGTTENSPV-TFAHFPEDtveqKAESVGRIMPHTEARimnmeagtLAKLNTPGELCIRGYCVMLGY 459
Cdd:cd05921 314 AVATvgeripMMAGLGATETAPTaTFTHWPTE----RSGLIGLPAPGTELK--------LVPSGGKYEVRVKGPNVTPGY 381
|
410 420
....*....|....*....|...
gi 572879274 460 WGEPQKTEEAVDQDKWYWTGDVA 482
Cdd:cd05921 382 WRQPELTAQAFDEEGFYCLGDAA 404
|
|
| PLN02654 |
PLN02654 |
acetate-CoA ligase |
475-601 |
2.35e-11 |
|
acetate-CoA ligase
Pssm-ID: 215353 [Multi-domain] Cd Length: 666 Bit Score: 66.84 E-value: 2.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 475 WYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEICACIRLKDGEETTVE 554
Cdd:PLN02654 514 YYFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTAEVESALVSHPQCAEAAVVGIEHEVKGQGIYAFVTLVEGVPYSEE 593
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 572879274 555 EIKAF---CKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQMERHLN 601
Cdd:PLN02654 594 LRKSLiltVRNQIGAFAAPDKIHWAPGLPKTRSGKIMRRILRKIASRQLD 643
|
|
| prpE |
PRK10524 |
propionyl-CoA synthetase; Provisional |
82-587 |
4.84e-11 |
|
propionyl-CoA synthetase; Provisional
Pssm-ID: 182517 [Multi-domain] Cd Length: 629 Bit Score: 65.74 E-value: 4.84e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 82 AQRvPEREALVVL----HEDVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLATAQAMELEYVlkkv 157
Cdd:PRK10524 64 AKR-PEQLALIAVstetDEERTYTFRQLHDEVNRMAAMLRSLGVQRGDRVLIYMPMIAEAAFAMLACARIGAIHSV---- 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 158 gckalVFpKQFKTQqyyNVLKQIcpevENAQPgalksqrlpdlTTVISVDA------PLPGTLLLDEVVAAGST------ 225
Cdd:PRK10524 139 -----VF-GGFASH---SLAARI----DDAKP-----------VLIVSADAgsrggkVVPYKPLLDEAIALAQHkprhvl 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 226 -----------------------RQHLDQlQYNQQFLSCHDPINIQFTSGTTGSPKG-------------ATLSHynivn 269
Cdd:PRK10524 195 lvdrglapmarvagrdvdyatlrAQHLGA-RVPVEWLESNEPSYILYTSGTTGKPKGvqrdtggyavalaTSMDT----- 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 270 nsnILGerlklhektpeqlrmilpnplyhclGSVAGTMMCL-----MYGATLILASPIFNGKkaleaisrerGTFLY-GT 343
Cdd:PRK10524 269 ---IFG-------------------------GKAGETFFCAsdigwVVGHSYIVYAPLLAGM----------ATIMYeGL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 344 PT------------------MF-----VDILNQPD---FSSYDISTMCGGVIAGSPAPPELIRAIINKINmKDLVVAYGT 397
Cdd:PRK10524 311 PTrpdagiwwrivekykvnrMFsaptaIRVLKKQDpalLRKHDLSSLRALFLAGEPLDEPTASWISEALG-VPVIDNYWQ 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 398 TENSPVTFAHFP--EDTvEQKAESVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGY----CvMLGYWGepqkteeavD 471
Cdd:PRK10524 390 TETGWPILAIARgvEDR-PTRLGSPGVPMYGYNVKLLNEVTGEPCGPNEKGVLVIEGPlppgC-MQTVWG---------D 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 472 QDKW---YW---------TGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMGEEI 539
Cdd:PRK10524 459 DDRFvktYWslfgrqvysTFDWGIRDADGYYFILGRTDDVINVAGHRLGTREIEESISSHPAVAEVAVVGVKDALKGQVA 538
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*.
gi 572879274 540 CACIRLKDGEETTVE--------EIKAFCKGKISHFKIPKYIVFVTNYPLTISGKI 587
Cdd:PRK10524 539 VAFVVPKDSDSLADRearlalekEIMALVDSQLGAVARPARVWFVSALPKTRSGKL 594
|
|
| PRK05691 |
PRK05691 |
peptide synthase; Validated |
249-589 |
2.40e-10 |
|
peptide synthase; Validated
Pssm-ID: 235564 [Multi-domain] Cd Length: 4334 Bit Score: 64.03 E-value: 2.40e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 249 FTSGTTGSPKGATLSHYNIVNNSNILGERL-------KLH------EKTPEqlRMILPnplyhclgsvagtmmcLMYGAT 315
Cdd:PRK05691 2340 YTSGSTGKPKGVVVSHGEIAMHCQAVIERFgmraddcELHfysinfDAASE--RLLVP----------------LLCGAR 2401
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 316 LILASpifNGKKALEAIS---RERGTFLYG-TPTmFVDILNQPDFSSYDIST--MCggVIAGSPAPPELIRAIINKINMK 389
Cdd:PRK05691 2402 VVLRA---QGQWGAEEICqliREQQVSILGfTPS-YGSQLAQWLAGQGEQLPvrMC--ITGGEALTGEHLQRIRQAFAPQ 2475
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 390 DLVVAYGTTENSPVTFAHFPEDTVEQKAESV--GRIMPHTEARIMNMEAGTLAKLNTpGELCIRGYCVMLGYWGEPQKTE 467
Cdd:PRK05691 2476 LFFNAYGPTETVVMPLACLAPEQLEEGAASVpiGRVVGARVAYILDADLALVPQGAT-GELYVGGAGLAQGYHDRPGLTA 2554
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 468 E-------AVDQDKWYWTGDVATMNEQGFCKIVGRSKDMI-IRGGEnIYPAELEDFFHTHPKVQEVQVVGVkDDRMGEEI 539
Cdd:PRK05691 2555 ErfvadpfAADGGRLYRTGDLVRLRADGLVEYVGRIDHQVkIRGFR-IELGEIESRLLEHPAVREAVVLAL-DTPSGKQL 2632
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 572879274 540 C---ACIRLKDGEETTV---EEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQK 589
Cdd:PRK05691 2633 AgylVSAVAGQDDEAQAalrEALKAHLKQQLPDYMVPAHLILLDSLPLTANGKLDR 2688
|
|
| hsFATP4_like |
cd05939 |
Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty ... |
97-595 |
1.14e-09 |
|
Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins; Fatty acid transport protein (FATP) transports long-chain or very-long-chain fatty acids across the plasma membrane. At least five copies of FATPs are identified in mammalian cells. This family includes FATP4, FATP1, and homologous proteins. Each FATP has unique patterns of tissue distribution. FATP4 is mainly expressed in the brain, testis, colon and kidney. FATPs also have fatty acid CoA synthetase activity, thus playing dual roles as fatty acid transporters and its activation enzymes. FATPs are the key players in the trafficking of exogenous fatty acids into the cell and in intracellular fatty acid homeostasis.
Pssm-ID: 341262 [Multi-domain] Cd Length: 474 Bit Score: 60.90 E-value: 1.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 97 DVRLTFAQLKEEVDKAASGLLSIGLCKGDRLGMWGPNSYAWVLMQLAtaqameleyvLKKVGCKALVFPKQFKTQQYYNv 176
Cdd:cd05939 1 DRHWTFRELNEYSNKVANFFQAQGYRSGDVVALFMENRLEFVALWLG----------LAKIGVETALINSNLRLESLLH- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 177 lkqiCPEVENAQpgALKSQRLPDLTTVISVDAPlpgtllldevvaagstrqhldqlqyNQQFLSCHDPINIQFTSGTTGS 256
Cdd:cd05939 70 ----CITVSKAK--ALIFNLLDPLLTQSSTEPP-------------------------SQDDVNFRDKLFYIYTSGTTGL 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 257 PKGATLSHYNIVNNSNILGERLKLHEKTpeqlRMILPNPLYHCLGSVAGTMMCLMYGATLILASPiFNGKKALEAISRER 336
Cdd:cd05939 119 PKAAVIVHSRYYRIAAGAYYAFGMRPED----VVYDCLPLYHSAGGIMGVGQALLHGSTVVIRKK-FSASNFWDDCVKYN 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 337 GTFLYGTPTMFVDILNQPdfSSYDISTMCGGVIAGSPAPPELIRAIINKINMKDLVVAYGTTE-NSPVTfahfpedTVEQ 415
Cdd:cd05939 194 CTIVQYIGEICRYLLAQP--PSEEEQKHNVRLAVGNGLRPQIWEQFVRRFGIPQIGEFYGATEgNSSLV-------NIDN 264
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 416 KAESVG---RIMPHT-EARIMNMEAGTLAKLNTPGELCIR------GYCV-----------MLGYWGEP---QKTEEAVD 471
Cdd:cd05939 265 HVGACGfnsRILPSVyPIRLIKVDEDTGELIRDSDGLCIPcqpgepGLLVgkiiqndplrrFDGYVNEGatnKKIARDVF 344
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 472 Q--DKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRM-GEEICACIRLKDg 548
Cdd:cd05939 345 KkgDSAFLSGDVLVMDELGYLYFKDRTGDTFRWKGENVSTTEVEGILSNVLGLEDVVVYGVEVPGVeGRAGMAAIVDPE- 423
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 572879274 549 EETTVEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKLREQ 595
Cdd:cd05939 424 RKVDLDRFSAVLAKSLPPYARPQFIRLLPEVDKTGTFKLQKTDLQKE 470
|
|
| PTZ00237 |
PTZ00237 |
acetyl-CoA synthetase; Provisional |
240-589 |
1.52e-09 |
|
acetyl-CoA synthetase; Provisional
Pssm-ID: 240325 [Multi-domain] Cd Length: 647 Bit Score: 60.91 E-value: 1.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 240 SCHdPINIQFTSGTTGSPKGATLShynivNNSNILGerLKLHEKTPEQLRMILPNPLYHCLGSVAGTMM---CLMYGATL 316
Cdd:PTZ00237 253 SSH-PLYILYTSGTTGNSKAVVRS-----NGPHLVG--LKYYWRSIIEKDIPTVVFSHSSIGWVSFHGFlygSLSLGNTF 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 317 ILASPIFNGKKALE-----AISRER-GTFLYGTPTMFVDILNQPD----FSSYDISTMCGGVIAGSPAPPELIRAIINKI 386
Cdd:PTZ00237 325 VMFEGGIIKNKHIEddlwnTIEKHKvTHTLTLPKTIRYLIKTDPEatiiRSKYDLSNLKEIWCGGEVIEESIPEYIENKL 404
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 387 NMKDLVVaYGTTENSPVTFAHFPEDTVEQKAesVGRIMPHTEARIMNmEAGTLAKLNTPGELCIR-----GYCVMLgywg 461
Cdd:PTZ00237 405 KIKSSRG-YGQTEIGITYLYCYGHINIPYNA--TGVPSIFIKPSILS-EDGKELNVNEIGEVAFKlpmppSFATTF---- 476
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 462 epQKTEEAVDQ-----DKWYWTGDVATMNEQGFCKIVGRSKDMIIRGGENIYPAELEDFFHTHPKVQEVQVVGVKDDRMG 536
Cdd:PTZ00237 477 --YKNDEKFKQlfskfPGYYNSGDLGFKDENGYYTIVSRSDDQIKISGNKVQLNTIETSILKHPLVLECCSIGIYDPDCY 554
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 537 EEICACIRLKDGEETTV-------EEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQK 589
Cdd:PTZ00237 555 NVPIGLLVLKQDQSNQSidlnklkNEINNIITQDIESLAVLRKIIIVNQLPKTKTGKIPR 614
|
|
| PRK12476 |
PRK12476 |
putative fatty-acid--CoA ligase; Provisional |
211-513 |
7.52e-09 |
|
putative fatty-acid--CoA ligase; Provisional
Pssm-ID: 171527 [Multi-domain] Cd Length: 612 Bit Score: 58.60 E-value: 7.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 211 PGTLLLDEV---VAAGSTRQHLDqlqynqqflsCHDPINIQFTSGTTGSPKGATLSHYNIVNNSnilgerlklhektpeq 287
Cdd:PRK12476 169 PRVIAIDAIpdsAGESFVPVELD----------TDDVSHLQYTSGSTRPPVGVEITHRAVGTNL---------------- 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 288 LRMIL------PN-------PLYHCLGsVAGTMMCLMYGATLILASPI-FNGK-----KALEAISRERGTFLyGTPTMFV 348
Cdd:PRK12476 223 VQMILsidlldRNthgvswlPLYHDMG-LSMIGFPAVYGGHSTLMSPTaFVRRpqrwiKALSEGSRTGRVVT-AAPNFAY 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 349 DILNQ----PDFSSYDISTMCggVIAGS-PAPPELIRAIiNKI----NMKDLVV--AYGTTE----------NSPVTFAH 407
Cdd:PRK12476 301 EWAAQrglpAEGDDIDLSNVV--LIIGSePVSIDAVTTF-NKAfapyGLPRTAFkpSYGIAEatlfvatiapDAEPSVVY 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 408 F-------------PEDTVEQKAE-SVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEE----- 468
Cdd:PRK12476 378 LdreqlgagravrvAADAPNAVAHvSCGQVARSQWAVIVDPDTGAELPDGEVGEIWLHGDNIGRGYWGRPEETERtfgak 457
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 572879274 469 -------------AVDQDKWYWTGDVATMNEqGFCKIVGRSKDMIIRGGENIYPAELE 513
Cdd:PRK12476 458 lqsrlaegshadgAADDGTWLRTGDLGVYLD-GELYITGRIADLIVIDGRNHYPQDIE 514
|
|
| PRK07769 |
PRK07769 |
long-chain-fatty-acid--CoA ligase; Validated |
203-513 |
1.86e-08 |
|
long-chain-fatty-acid--CoA ligase; Validated
Pssm-ID: 181109 [Multi-domain] Cd Length: 631 Bit Score: 57.43 E-value: 1.86e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 203 VISVDApLPgtlllDEVvaaGSTRQ----HLDQLQYnqqflschdpinIQFTSGTTGSPKGATLSHYNIVNNSNILGERL 278
Cdd:PRK07769 158 VIAVDA-VP-----DEV---GATWVppeaNEDTIAY------------LQYTSGSTRIPAGVQITHLNLPTNVLQVIDAL 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 279 KLHEKTpeqlRMILPNPLYHCLGSVAgTMMCLMYGATLILASPI-FNGK-----KALEAISRERGTFLYGTPTMFVDI-- 350
Cdd:PRK07769 217 EGQEGD----RGVSWLPFFHDMGLIT-VLLPALLGHYITFMSPAaFVRRpgrwiRELARKPGGTGGTFSAAPNFAFEHaa 291
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 351 ---LNQPDFSSYDISTMcGGVIAGS-PAPPELIR--------------AIINKINMKD--LVVAYGTTENSPvTFAHFPE 410
Cdd:PRK07769 292 argLPKDGEPPLDLSNV-KGLLNGSePVSPASMRkfneafapyglpptAIKPSYGMAEatLFVSTTPMDEEP-TVIYVDR 369
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 411 DT--------VEQKAE------SVGRIMPHTEARIMNMEAGTLAKLNTPGELCIRGYCVMLGYWGEPQKTEE-------- 468
Cdd:PRK07769 370 DElnagrfveVPADAPnavaqvSAGKVGVSEWAVIVDPETASELPDGQIGEIWLHGNNIGTGYWGKPEETAAtfqnilks 449
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 572879274 469 ---------AVDQDKWYWTGDVATMNEqGFCKIVGRSKDMIIRGGENIYPAELE 513
Cdd:PRK07769 450 rlseshaegAPDDALWVRTGDYGVYFD-GELYITGRVKDLVIIDGRNHYPQDLE 502
|
|
| PaaK |
COG1541 |
Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and ... |
250-535 |
4.06e-07 |
|
Phenylacetate-coenzyme A ligase PaaK, adenylate-forming domain family [Coenzyme transport and metabolism];
Pssm-ID: 441150 [Multi-domain] Cd Length: 423 Bit Score: 52.46 E-value: 4.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 250 TSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKTPEQLrmilpnpLYHCLG---SVAGTMM---CLMYGATLILASPIf 323
Cdd:COG1541 91 SSGTTGKPTVVGYTRKDLDRWAELFARSLRAAGVRPGDR-------VQNAFGyglFTGGLGLhygAERLGATVIPAGGG- 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 324 NGKKALEAISRERGTFLYGTPTMFVDILNQP-----DFSSYDISTmcgGVIAGSPAPPELIRAIINKINMKdLVVAYGTT 398
Cdd:COG1541 163 NTERQLRLMQDFGPTVLVGTPSYLLYLAEVAeeegiDPRDLSLKK---GIFGGEPWSEEMRKEIEERWGIK-AYDIYGLT 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 399 ENSPVTFA--------HFPEDTVeqkaesvgrimpHTEarIMNMEAGTLAKLNTPGEL-----------CIRgycvmlgy 459
Cdd:COG1541 239 EVGPGVAYeceaqdglHIWEDHF------------LVE--IIDPETGEPVPEGEEGELvvttltkeampLIR-------- 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 460 wgepqkteeavdqdkwYWTGDVATMNEqGFC----------KIVGRSKDMIIRGGENIYPAELEDFFHTHPKV-QEVQVV 528
Cdd:COG1541 297 ----------------YRTGDLTRLLP-EPCpcgrthprigRILGRADDMLIIRGVNVFPSQIEEVLLRIPEVgPEYQIV 359
|
....*..
gi 572879274 529 GVKDDRM 535
Cdd:COG1541 360 VDREGGL 366
|
|
| alpha_am_amid |
TIGR03443 |
L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are ... |
249-592 |
9.01e-06 |
|
L-aminoadipate-semialdehyde dehydrogenase; Members of this protein family are L-aminoadipate-semialdehyde dehydrogenase (EC 1.2.1.31), product of the LYS2 gene. It is also called alpha-aminoadipate reductase. In fungi, lysine is synthesized via aminoadipate. Currently, all members of this family are fungal.
Pssm-ID: 274582 [Multi-domain] Cd Length: 1389 Bit Score: 48.91 E-value: 9.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 249 FTSGTTGSPKGATLSHYNIVNNSNILGERLKLHEKT-----------PEQLRMILPnplyhclgsvagtmmcLMYGATLI 317
Cdd:TIGR03443 422 FTSGSEGIPKGVLGRHFSLAYYFPWMAKRFGLSENDkftmlsgiahdPIQRDMFTP----------------LFLGAQLL 485
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 318 L--ASPIFNGKKALEAISRERGTFLYGTPTM-------------------FV-DILNQPDFSSydISTMCGGViagspap 375
Cdd:TIGR03443 486 VptADDIGTPGRLAEWMAKYGATVTHLTPAMgqllsaqattpipslhhafFVgDILTKRDCLR--LQTLAENV------- 556
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 376 peliraiiNKINMkdlvvaYGTTENS-PVTFAHFP----EDTVEQKAESV---GRIMPHTEARIMNMEAGT-LAKLNTPG 446
Cdd:TIGR03443 557 --------CIVNM------YGTTETQrAVSYFEIPsrssDSTFLKNLKDVmpaGKGMKNVQLLVVNRNDRTqTCGVGEVG 622
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 447 ELCIRGYCVMLGYWGEPQKTEEA------VDQDKW----------------------YWTGDVATMNEQGFCKIVGRSKD 498
Cdd:TIGR03443 623 EIYVRAGGLAEGYLGLPELNAEKfvnnwfVDPSHWidldkennkperefwlgprdrlYRTGDLGRYLPDGNVECCGRADD 702
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 499 MI-IRGGEnIYPAELEDFFHTHPKVQEvQVVGVKDDRMGE--------------EICACIRLKDGEETT----------- 552
Cdd:TIGR03443 703 QVkIRGFR-IELGEIDTHLSQHPLVRE-NVTLVRRDKDEEptlvsyivpqdksdELEEFKSEVDDEESSdpvvkglikyr 780
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 572879274 553 --VEEIKAFCKGKISHFKIPKYIVFVTNYPLTISGKIQKFKL 592
Cdd:TIGR03443 781 klIKDIREYLKKKLPSYAIPTVIVPLKKLPLNPNGKVDKPAL 822
|
|
| PaaK |
cd05913 |
Phenylacetate-CoA ligase (also known as PaaK); PaaK catalyzes the first step in the aromatic ... |
476-568 |
1.58e-04 |
|
Phenylacetate-CoA ligase (also known as PaaK); PaaK catalyzes the first step in the aromatic degradation pathway, by converting phenylacetic acid (PA) into phenylacetyl-CoA (PA-CoA). Phenylacetate-CoA ligase has been found in proteobacteria as well as gram positive prokaryotes. The enzyme is specifically induced after aerobic growth in a chemically defined medium containing PA or phenylalanine (Phe) as the sole carbon source. PaaKs are members of the adenylate-forming enzyme (AFE) family. However, sequence comparison reveals divergent features of PaaK with respect to the superfamily, including a novel N-terminal sequence.
Pssm-ID: 341239 [Multi-domain] Cd Length: 425 Bit Score: 44.54 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 572879274 476 YWTGDVATMN-EQGFC--------KIVGRSKDMIIRGGENIYPAELEDFFHTHPKV-QEVQVVGVKDDRMGEeicacIRL 545
Cdd:cd05913 293 YRTRDITRLLpGPCPCgrthrridRITGRSDDMLIIRGVNVFPSQIEDVLLKIPGLgPHYQLILTRQEHLDE-----LTI 367
|
90 100
....*....|....*....|....*.
gi 572879274 546 K---DGEETTVEEIKAFCKGKISHFK 568
Cdd:cd05913 368 KvevRPEADDDEKLEALKQRLERHIK 393
|
|
| |
