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Conserved domains on  [gi|574584349|ref|NP_001276102|]
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zinc finger protein 227 isoform e [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12017129)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 23-63 4.45e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 4.45e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 574584349   23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLVAVG 63
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
378-751 3.26e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 3.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 378 KPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDV--CGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF 455
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 456 RVHTGE-KPYKCKECGKGFSQ--------ASNLQVHQNVHTGEKRFKCET--------------CGKGFSQSSKLQTHQR 512
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSrdpqlpdlLSISNLRNNPLPGNNSSSVNTpqsnslhpplpansLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 513 VHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGEKPYKCEECGKGF------SWRSNLHAHQRVHSGEKPYKCEQCDKSFS 586
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 587 QAIDFRVHQRVHTG-EKPYKCGVCGKGFSQSSGLQSHQR--VHTGE--KPYKCDV--CGKGFRYSSQFIYHQRGHTGEKP 659
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 660 YKC--EECGKGFGRSLNLRHHQRVH-----TGEKPHICE--ECGKAFSLPSNLRVHLGVHT--REKLFKCEECGKGFSQS 728
Cdd:COG5048  352 AKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRH 431

                        410       420
                 ....*....|....*....|...
gi 574584349 729 ARLEAHQRVHTGEKPYKCDICDK 751
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-335 2.97e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.97e-03
                          10        20
                  ....*....|....*....|..
gi 574584349  314 HYRTHTGEKPYKCEECGKCFSQ 335
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 23-63 4.45e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 4.45e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 574584349   23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLVAVG 63
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
23-65 4.49e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 81.48  E-value: 4.49e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 574584349    23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLVAVGSK 65
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 23-60 5.93e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.12  E-value: 5.93e-15
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 574584349  23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLV 60
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
378-751 3.26e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 3.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 378 KPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDV--CGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF 455
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 456 RVHTGE-KPYKCKECGKGFSQ--------ASNLQVHQNVHTGEKRFKCET--------------CGKGFSQSSKLQTHQR 512
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSrdpqlpdlLSISNLRNNPLPGNNSSSVNTpqsnslhpplpansLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 513 VHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGEKPYKCEECGKGF------SWRSNLHAHQRVHSGEKPYKCEQCDKSFS 586
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 587 QAIDFRVHQRVHTG-EKPYKCGVCGKGFSQSSGLQSHQR--VHTGE--KPYKCDV--CGKGFRYSSQFIYHQRGHTGEKP 659
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 660 YKC--EECGKGFGRSLNLRHHQRVH-----TGEKPHICE--ECGKAFSLPSNLRVHLGVHT--REKLFKCEECGKGFSQS 728
Cdd:COG5048  352 AKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRH 431

                        410       420
                 ....*....|....*....|...
gi 574584349 729 ARLEAHQRVHTGEKPYKCDICDK 751
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKS 454
zf-H2C2_2 pfam13465
Zinc-finger double domain;
366-391 7.59e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.59e-04
                          10        20
                  ....*....|....*....|....*.
gi 574584349  366 NLRVHQRVHRGEKPYKCEECGKGFTQ 391
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-335 2.97e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.97e-03
                          10        20
                  ....*....|....*....|..
gi 574584349  314 HYRTHTGEKPYKCEECGKCFSQ 335
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 23-63 4.45e-19

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 80.98  E-value: 4.45e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 574584349   23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLVAVG 63
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
23-65 4.49e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 81.48  E-value: 4.49e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 574584349    23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLVAVGSK 65
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 23-60 5.93e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.12  E-value: 5.93e-15
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 574584349  23 VTFKDVAVVFSREELRLLDLTQRKLYRDVMVENFKNLV 60
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
378-751 3.26e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 3.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 378 KPYKCEECGKGFTQAAHFHIHQRVHTGEKPYKCDV--CGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIHF 455
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 456 RVHTGE-KPYKCKECGKGFSQ--------ASNLQVHQNVHTGEKRFKCET--------------CGKGFSQSSKLQTHQR 512
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSrdpqlpdlLSISNLRNNPLPGNNSSSVNTpqsnslhpplpansLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 513 VHTGEKPYRCDVCGKDFSYSSNLKLHQVIHTGEKPYKCEECGKGF------SWRSNLHAHQRVHSGEKPYKCEQCDKSFS 586
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 587 QAIDFRVHQRVHTG-EKPYKCGVCGKGFSQSSGLQSHQR--VHTGE--KPYKCDV--CGKGFRYSSQFIYHQRGHTGEKP 659
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 660 YKC--EECGKGFGRSLNLRHHQRVH-----TGEKPHICE--ECGKAFSLPSNLRVHLGVHT--REKLFKCEECGKGFSQS 728
Cdd:COG5048  352 AKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLsfRPYNCKNPPCSKSFNRH 431

                        410       420
                 ....*....|....*....|...
gi 574584349 729 ARLEAHQRVHTGEKPYKCDICDK 751
Cdd:COG5048  432 YNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
247-678 1.42e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 247 EKCFSQSSHLRTHQRIHPGEKLNRCHESGD---CFNKSSFHSYQSNHTGEKSYRC-DSCGKGFSSSTGLIIHYRTHTGEK 322
Cdd:COG5048   40 TDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdksFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSND 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 323 PYKCEECGKCFSQSSNFQCHQRVHTEEKPYKCEECGkgfgwsvnlrvhqrvhrgekpykceecGKGFTQAAHFHIHQRVH 402
Cdd:COG5048  120 NNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNN---------------------------SSSVNTPQSNSLHPPLP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 403 TGEKpykcdvCGKGFSHNSPLICHRRVHTGEKPYKCEACGKgFTRNTDLHIHFRVHTGEKPYKCKECGKGFSQASNLQVH 482
Cdd:COG5048  173 ANSL------SKDPSSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSP 245

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 483 QNVHTGEKRFKCETCG------KGFSQSSKLQTHQRVHTG-EKPYRCDVCGKDFSYSSNLKLHQ--VIHTGE--KPYKCE 551
Cdd:COG5048  246 SSLSSSDSSSSASESPrsslptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCP 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 552 E--CGKGFSWRSNLHAHQRVHSGEKPYKC--EQCDKSFSQAIDFRVHQRV--HTGEKPYKCGV-----CGKGFSQSSGLQ 620
Cdd:COG5048  326 YslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLqqYKDLKNDKKSEtlsnsCIRNFKRDSNLS 405

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 621 SHQRVHTGEKP--YKCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKgFGRSLNLRHH 678
Cdd:COG5048  406 LHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 572-655 2.26e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.41  E-value: 2.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 572 GEKPYKCE--QCDKSFSQAIDFRVHqRVHtgekpykcGVCGKGFSQSSGLQSHQRVHTGEKPYKCDVCGKGFRYSSQFIY 649
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 574584349 650 HqRGHT 655
Cdd:COG5189  417 H-RKHS 421
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
492-770 1.79e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 492 FKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKL--HQVIHTGEKPYKCEECGKG--FSWRSNLHAHQ 567
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELsrHLRTHHNNPSDLNSKSLPLsnSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 568 RVHS--GEKPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQSSGLQ-------------------SHQRVH 626
Cdd:COG5048  114 SSNSndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHpplpanslskdpssnlsllISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 627 TGEKPYKCDVCGKGFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTGEKPHICEECG------KAFSLP 700
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQSS 273

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 574584349 701 SNLRVHLGVHTREKL-FKCEECGKGFSQSARLEAHQR--VHTGE--KPYKCDI--CDKDFRHRSRLTYHQKVHTGKK 770
Cdd:COG5048  274 SPNESDSSSEKGFSLpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350
zf-H2C2_2 pfam13465
Zinc-finger double domain;
366-391 7.59e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.59e-04
                          10        20
                  ....*....|....*....|....*.
gi 574584349  366 NLRVHQRVHRGEKPYKCEECGKGFTQ 391
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
619-643 7.97e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.97e-04
                          10        20
                  ....*....|....*....|....*
gi 574584349  619 LQSHQRVHTGEKPYKCDVCGKGFRY 643
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
507-531 8.21e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.21e-04
                          10        20
                  ....*....|....*....|....*
gi 574584349  507 LQTHQRVHTGEKPYRCDVCGKDFSY 531
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 460-538 1.08e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 1.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 460 GEKPYKCK--ECGKGFSQASNLQVHQnvhtgekrfKCETCGKGFSQSSKLQTHQRVHTGEKPYRCDVCGKDFSYSSNLKL 537
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 .
gi 574584349 538 H 538
Cdd:COG5189  417 H 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 589-683 1.42e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 589 IDFRVHQRVHTGEKPYKCGV--CGKGFSQSSGLQSHqRVHTGEKPYKCDVCGKgfryssqfIYHQRGHTGEKPYKCEECG 666
Cdd:COG5189  335 IDTPSRMLKVKDGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCD 405

                         90
                 ....*....|....*..
gi 574584349 667 KGFGRSLNLRHHqRVHT 683
Cdd:COG5189  406 KRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 544-627 1.42e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 544 GEKPYKCE--ECGKGFSWRSNLHAHqRVHSGEKPYKCEQCDKSfsqaidfrVHQRVHTGEKPYKCGVCGKGFSQSSGLQS 621
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 574584349 622 HqRVHT 627
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
730-755 2.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.30e-03
                          10        20
                  ....*....|....*....|....*.
gi 574584349  730 RLEAHQRVHTGEKPYKCDICDKDFRH 755
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
534-558 2.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.89e-03
                          10        20
                  ....*....|....*....|....*
gi 574584349  534 NLKLHQVIHTGEKPYKCEECGKGFS 558
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-335 2.97e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.97e-03
                          10        20
                  ....*....|....*....|..
gi 574584349  314 HYRTHTGEKPYKCEECGKCFSQ 335
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 684-764 3.58e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 3.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 684 GEKPHICE--ECGKAFSLPSNLRVHLgvhtreklfKCEECGKGFSQSARLEAHQRVHTGEKPYKCDICDKDFRHRSRLTY 761
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 574584349 762 HQK 764
Cdd:COG5189  417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
566-587 4.45e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.45e-03
                          10        20
                  ....*....|....*....|..
gi 574584349  566 HQRVHSGEKPYKCEQCDKSFSQ 587
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
454-475 5.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.58e-03
                          10        20
                  ....*....|....*....|..
gi 574584349  454 HFRVHTGEKPYKCKECGKGFSQ 475
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
398-419 5.74e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.74e-03
                          10        20
                  ....*....|....*....|..
gi 574584349  398 HQRVHTGEKPYKCDVCGKGFSH 419
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 376-427 6.06e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 6.06e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 574584349 376 GEKPYKCE--ECGKGFTQA-------AHFHIHQRVH------------TGEKPYKCDVCGKGFSHNSPLICHR 427
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQnglkyhmLHGHQNQKLHenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 628-708 6.67e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 6.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 574584349 628 GEKPYKCDVCGKGFRYSSQF--IYHQR-GHTGEKPYKCEECGKgfgrslnlrhHQRVHTGEKPHICEECGKAFSLPSNLR 704
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNglKYHMLhGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....
gi 574584349 705 VHLG 708
Cdd:COG5189  416 YHRK 419
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 464-486 7.97e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.97e-03
                          10        20
                  ....*....|....*....|...
gi 574584349  464 YKCKECGKGFSQASNLQVHQNVH 486
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
590-615 8.26e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 8.26e-03
                          10        20
                  ....*....|....*....|....*.
gi 574584349  590 DFRVHQRVHTGEKPYKCGVCGKGFSQ 615
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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