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Conserved domains on  [gi|575403005|ref|NP_001276400|]
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Krueppel-like factor 10 isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 33-368 7.25e-64

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


:

Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 205.61  E-value: 7.25e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005  33 AEQSDFEAVEALMSMSCDWKSHFKKYLENRPVTPVSDTSEDDsLLPGTPDLQTVPAFCLTPPYSPSDFEPSQGSNLTasa 112
Cdd:cd21572    1 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDD-DLPSPADFHDSPPFCMTPPYSPPHFEATHPPSAA--- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005 113 pstghfksfsdAAKPPGATPFKEEEKNPLAAPPLPKAQATSVIRHTADAQLCNHQSCPvkaasilnyqdnsfrrrthgnv 192
Cdd:cd21572   77 -----------TLHPPAAQPPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCP---------------------- 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005 193 eatrknipcaavspnrskpepstvsdgdekagaalydfavpssetvicrsqpapsspvQKSVLVSSPTVSTGGVPPLPVI 272
Cdd:cd21572  124 ----------------------------------------------------------SSPSVVPSVPAGVAGVSPVPVY 145

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005 273 CQMVPLPANNS-LVSTVVPSTPPSQPPAVCSPVLFMGTQVPEGTVV--FVVPQPVVQSPRPPVVSPSGTRLSPIAPAPGF 349
Cdd:cd21572  146 CQILPVSSSSTtVVAAQAPLPQPQQQAASPAQVFLMGGQVPKGPVMflVPQPVVPTLYVQPTLVTPGGTKLAAIAPAPGH 225

                        330       340
                 ....*....|....*....|
gi 575403005 350 SPSAAR-VTPQIDSSRVRSH 368
Cdd:cd21572  226 TPSEQRkSPPQPEVSRVRSH 245
zf-H2C2_2 pfam13465
Zinc-finger double domain;
384-411 1.82e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.82e-04
                          10        20
                  ....*....|....*....|....*...
gi 575403005  384 HLKAHVRTHTGEKPFSCswKGCERRFAR 411
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 368-392 2.40e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.40e-03
                          10        20
                  ....*....|....*....|....*
gi 575403005  368 HICSHpgCGKTYFKSSHLKAHVRTH 392
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 33-368 7.25e-64

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 205.61  E-value: 7.25e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005  33 AEQSDFEAVEALMSMSCDWKSHFKKYLENRPVTPVSDTSEDDsLLPGTPDLQTVPAFCLTPPYSPSDFEPSQGSNLTasa 112
Cdd:cd21572    1 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDD-DLPSPADFHDSPPFCMTPPYSPPHFEATHPPSAA--- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005 113 pstghfksfsdAAKPPGATPFKEEEKNPLAAPPLPKAQATSVIRHTADAQLCNHQSCPvkaasilnyqdnsfrrrthgnv 192
Cdd:cd21572   77 -----------TLHPPAAQPPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCP---------------------- 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005 193 eatrknipcaavspnrskpepstvsdgdekagaalydfavpssetvicrsqpapsspvQKSVLVSSPTVSTGGVPPLPVI 272
Cdd:cd21572  124 ----------------------------------------------------------SSPSVVPSVPAGVAGVSPVPVY 145

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005 273 CQMVPLPANNS-LVSTVVPSTPPSQPPAVCSPVLFMGTQVPEGTVV--FVVPQPVVQSPRPPVVSPSGTRLSPIAPAPGF 349
Cdd:cd21572  146 CQILPVSSSSTtVVAAQAPLPQPQQQAASPAQVFLMGGQVPKGPVMflVPQPVVPTLYVQPTLVTPGGTKLAAIAPAPGH 225

                        330       340
                 ....*....|....*....|
gi 575403005 350 SPSAAR-VTPQIDSSRVRSH 368
Cdd:cd21572  226 TPSEQRkSPPQPEVSRVRSH 245
zf-H2C2_2 pfam13465
Zinc-finger double domain;
384-411 1.82e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.82e-04
                          10        20
                  ....*....|....*....|....*...
gi 575403005  384 HLKAHVRTHTGEKPFSCswKGCERRFAR 411
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
PHA03247 PHA03247
large tegument protein UL36; Provisional
 76-358 2.18e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005   76 LLPGTPDlQTVPafclTPPYSPSDFEPSQGSNLT---ASAPSTGHFKSFSDAAKPPGA---TPFKEEEKNPLAAPPLPKA 149
Cdd:PHA03247 2559 APPAAPD-RSVP----PPRPAPRPSEPAVTSRARrpdAPPQSARPRAPVDDRGDPRGPappSPLPPDTHAPDPPPPSPSP 2633

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005  150 QATSVIRHTADAQLCNHQSCPVKAASILnyqdnSFRRRthgnveATRKNIPCAAVSPNRsKPEPSTVSDgdekAGAALYD 229
Cdd:PHA03247 2634 AANEPDPHPPPTVPPPERPRDDPAPGRV-----SRPRR------ARRLGRAAQASSPPQ-RPRRRAARP----TVGSLTS 2697

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005  230 FAVPSSETVICRSQP------APSSPVQKSVLVSSPTVSTGGVPPLPVICQMVPL----PANNSLVSTVVPSTPPSQPPA 299
Cdd:PHA03247 2698 LADPPPPPPTPEPAPhalvsaTPLPPGPAAARQASPALPAAPAPPAVPAGPATPGgparPARPPTTAGPPAPAPPAAPAA 2777

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 575403005  300 VCSPVLFMGTQVPEGTVVFVVPQPVVQSPRPPVVSPSGTRLSPIAPAPGFSPSAARVTP 358
Cdd:PHA03247 2778 GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP 2836
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 368-392 2.40e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.40e-03
                          10        20
                  ....*....|....*....|....*
gi 575403005  368 HICSHpgCGKTYFKSSHLKAHVRTH 392
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
373-423 3.50e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 3.50e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 575403005 373 PGCGKTYFKSSHLKAHVRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHT 423
Cdd:COG5048   37 PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 211-378 8.42e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 38.74  E-value: 8.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005  211 PEPSTVSDGDEKAGaalydFAVPSSETVICRSQPAPSSPVQKSVlvSSPTVSTGGVPPlpvicqmvPLPA-NNSLVSTVV 289
Cdd:pfam05109 425 PESTTTSPTLNTTG-----FAAPNTTTGLPSSTHVPTNLTAPAS--TGPTVSTADVTS--------PTPAgTTSGASPVT 489

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005  290 PSTPP------SQPPAVCSPVLFMGTQVPEGTVVFVVPQpvvqSPRPPVVSPSGTRLSPIAPAPGFSPSAARVTPQIDSS 363
Cdd:pfam05109 490 PSPSPrdngteSKAPDMTSPTSAVTTPTPNATSPTPAVT----TPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTP 565

                         170
                  ....*....|....*
gi 575403005  364 RVRSHIcshPGCGKT 378
Cdd:pfam05109 566 TPNATI---PTLGKT 577
 
Name Accession Description Interval E-value
KLF10_N cd21572
N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as ...
 33-368 7.25e-64

N-terminal domain of Kruppel-like factor 10; Kruppel-like factor 10 (KLF10; also known as Krueppel-like factor 10; early growth response(EGR)-alpha/EGRA; TGFbeta inducible early gene-1/TIEG1) is a protein that in humans is encoded by the KLF10 gene. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. It may also play a role in adipocyte differentiation and adipose tissue function. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10.


Pssm-ID: 409241 [Multi-domain]  Cd Length: 245  Bit Score: 205.61  E-value: 7.25e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005  33 AEQSDFEAVEALMSMSCDWKSHFKKYLENRPVTPVSDTSEDDsLLPGTPDLQTVPAFCLTPPYSPSDFEPSQGSNLTasa 112
Cdd:cd21572    1 MGAGDMEAVEALMSMTKHWKTRSFRLRHFRPLTPSSDSSEDD-DLPSPADFHDSPPFCMTPPYSPPHFEATHPPSAA--- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005 113 pstghfksfsdAAKPPGATPFKEEEKNPLAAPPLPKAQATSVIRHTADAQLCNHQSCPvkaasilnyqdnsfrrrthgnv 192
Cdd:cd21572   77 -----------TLHPPAAQPPEEQHLSAETAASQQRFQCTSVIRHTADAQPCSCSSCP---------------------- 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005 193 eatrknipcaavspnrskpepstvsdgdekagaalydfavpssetvicrsqpapsspvQKSVLVSSPTVSTGGVPPLPVI 272
Cdd:cd21572  124 ----------------------------------------------------------SSPSVVPSVPAGVAGVSPVPVY 145

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005 273 CQMVPLPANNS-LVSTVVPSTPPSQPPAVCSPVLFMGTQVPEGTVV--FVVPQPVVQSPRPPVVSPSGTRLSPIAPAPGF 349
Cdd:cd21572  146 CQILPVSSSSTtVVAAQAPLPQPQQQAASPAQVFLMGGQVPKGPVMflVPQPVVPTLYVQPTLVTPGGTKLAAIAPAPGH 225

                        330       340
                 ....*....|....*....|
gi 575403005 350 SPSAAR-VTPQIDSSRVRSH 368
Cdd:cd21572  226 TPSEQRkSPPQPEVSRVRSH 245
KLF10_11_N cd21974
N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily ...
 34-368 9.70e-58

N-terminal domain of Kruppel-like factor (KLF) 10, KLF11, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 10, KLF11, and similar proteins. KLF10 was first identified in human osteoblasts and plays a role in mediating estrogen (E2) signaling in bone and skeletal homeostasis and a regulatory role in tumor formation and metastasis. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF10/11 belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF10, KLF11, and similar proteins.


Pssm-ID: 409243 [Multi-domain]  Cd Length: 229  Bit Score: 189.37  E-value: 9.70e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005  34 EQSDFEAVEALMSMSCDWKSHFKKYLENRPVTPVSDTSEDDSLLPGTPDLQTVPAFCLTPPYSPSDFEPSQGSNLTASAP 113
Cdd:cd21974    1 EQGDLEAVEALVSMSSWWKRRQKRLRKPRPLTPSSDSSDEDDAPESPKDFHSLSSLCMTPPYSPPFFEASHSPSVASLHP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005 114 STghfksfsdaakPPGATPFKEEEKNPLAAPPLPKAQATSVIRHTADAqlcnhqscpvkaasilnyqdnsfrrrthgnve 193
Cdd:cd21974   81 PS-----------AASSQPPPEPESSEPPAASPQRAQATSVIRHTADP-------------------------------- 117

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005 194 atrknipcaavspnrskpepstvsdgdekagaalydfavpssetvicrsqpapsspvqksvlvssptvstGGVPPLPVIC 273
Cdd:cd21974  118 ----------------------------------------------------------------------VPVSPPPVLC 127

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005 274 QMVPLPANNSLVS-----TVVPSTPPSQPPAVCSPVLFMGTQVPEGTVV--FVVPQPVVQSPRPPVVSPSGTRLSPIAPA 346
Cdd:cd21974  128 QMLPVSSSSGVIVaflkaPQQPSPQPQKPALPQPQVVLVGGQVPQGPVMlvVPQPAVPQPYVQPTVVTPGGTKLLPIAPA 207

                        330       340
                 ....*....|....*....|..
gi 575403005 347 PGFSPSAARVTPQIDSSRVRSH 368
Cdd:cd21974  208 PGFIPSGQSSAPQPDFSRRRNH 229
KLF11_N cd21584
N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as ...
 34-366 4.77e-18

N-terminal domain of Kruppel-like factor 11; Kruppel-like factor 11 (KLF11; also known as Krueppel-like factor 11; Fetal Kruppel-like factor-1/FKLF-1; maturity-onset diabetes of the young 7/MODY7; TGFbeta Inducible Early Growth Response 2/TIEG2) is a protein that in humans is encoded by the KLF11 gene. KLF11 is involved in cell growth, apoptosis, cellular inflammation and differentiation, endometriosis, and cholesterol, prostaglandin, neurotransmitter, fat, and sugar metabolism. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved a-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF11 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF11.


Pssm-ID: 409242 [Multi-domain]  Cd Length: 217  Bit Score: 82.35  E-value: 4.77e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005  34 EQSDFEAVEALMSMScDW--KSHFKKYLENRPVTPVSDTSEDDSLLPGTP----DLQTVPAFCLTPPYSPSDFEPSQGsn 107
Cdd:cd21584    2 EQNDLEAVEALVCMS-SWgqRSQKGDLLKIRPLTPASDSCDSLTLHPAAPelpkDFHSLSSLCMTPPHSPSFAEPSTT-- 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005 108 ltasapstghfksfsdaakppgatpfkeeeknplAAPPLPKAQATSVIRHTADaqlcnhqscpvkaasilnyqdnsfrrr 187
Cdd:cd21584   79 ----------------------------------APPPPCRAMATSVIRHTAD--------------------------- 97

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005 188 thgnveatrknipcaavspnrskpepstvsdgdekagaalydfavpssetvicrsqpapsspvqksvlvSSPTVStggVP 267
Cdd:cd21584   98 ---------------------------------------------------------------------SSPPVP---VP 105

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005 268 PLPVICQMVPLPANNSLVSTVVPSTPPSQPP--------AVCSPVLFMGTQVPEGTVV---FVVPQPVVQSPRPPVVSPS 336
Cdd:cd21584  106 SPPVLCQMIPVSGQSGMISAFLQPPALSAGTvkpilpqtAPASQPLLVGSPVPQGTVMlvlPQASVPQPPQCPQTVMTLG 185

                        330       340       350
                 ....*....|....*....|....*....|
gi 575403005 337 GTRLSPIAPAPGFSPSAARVTPQIDSSRVR 366
Cdd:cd21584  186 NTKLLPLAPAPVFIPSGQSCAPQVDFSRRR 215
zf-H2C2_2 pfam13465
Zinc-finger double domain;
384-411 1.82e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.82e-04
                          10        20
                  ....*....|....*....|....*...
gi 575403005  384 HLKAHVRTHTGEKPFSCswKGCERRFAR 411
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
PHA03247 PHA03247
large tegument protein UL36; Provisional
 76-358 2.18e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 2.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005   76 LLPGTPDlQTVPafclTPPYSPSDFEPSQGSNLT---ASAPSTGHFKSFSDAAKPPGA---TPFKEEEKNPLAAPPLPKA 149
Cdd:PHA03247 2559 APPAAPD-RSVP----PPRPAPRPSEPAVTSRARrpdAPPQSARPRAPVDDRGDPRGPappSPLPPDTHAPDPPPPSPSP 2633

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005  150 QATSVIRHTADAQLCNHQSCPVKAASILnyqdnSFRRRthgnveATRKNIPCAAVSPNRsKPEPSTVSDgdekAGAALYD 229
Cdd:PHA03247 2634 AANEPDPHPPPTVPPPERPRDDPAPGRV-----SRPRR------ARRLGRAAQASSPPQ-RPRRRAARP----TVGSLTS 2697

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005  230 FAVPSSETVICRSQP------APSSPVQKSVLVSSPTVSTGGVPPLPVICQMVPL----PANNSLVSTVVPSTPPSQPPA 299
Cdd:PHA03247 2698 LADPPPPPPTPEPAPhalvsaTPLPPGPAAARQASPALPAAPAPPAVPAGPATPGgparPARPPTTAGPPAPAPPAAPAA 2777

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 575403005  300 VCSPVLFMGTQVPEGTVVFVVPQPVVQSPRPPVVSPSGTRLSPIAPAPGFSPSAARVTP 358
Cdd:PHA03247 2778 GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP 2836
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 368-392 2.40e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.40e-03
                          10        20
                  ....*....|....*....|....*
gi 575403005  368 HICSHpgCGKTYFKSSHLKAHVRTH 392
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
373-423 3.50e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 3.50e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 575403005 373 PGCGKTYFKSSHLKAHVRTHTGEKPFSCSWKGCERRFARSDELSRHRRTHT 423
Cdd:COG5048   37 PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHH 87
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 211-378 8.42e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 38.74  E-value: 8.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005  211 PEPSTVSDGDEKAGaalydFAVPSSETVICRSQPAPSSPVQKSVlvSSPTVSTGGVPPlpvicqmvPLPA-NNSLVSTVV 289
Cdd:pfam05109 425 PESTTTSPTLNTTG-----FAAPNTTTGLPSSTHVPTNLTAPAS--TGPTVSTADVTS--------PTPAgTTSGASPVT 489

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005  290 PSTPP------SQPPAVCSPVLFMGTQVPEGTVVFVVPQpvvqSPRPPVVSPSGTRLSPIAPAPGFSPSAARVTPQIDSS 363
Cdd:pfam05109 490 PSPSPrdngteSKAPDMTSPTSAVTTPTPNATSPTPAVT----TPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTP 565

                         170
                  ....*....|....*
gi 575403005  364 RVRSHIcshPGCGKT 378
Cdd:pfam05109 566 TPNATI---PTLGKT 577
PHA03247 PHA03247
large tegument protein UL36; Provisional
 61-298 8.66e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.77  E-value: 8.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005   61 NRPVTPVSDTSEDDSLLPGTPDLQTVPAFCLTPPysPSDFEPSQGSNLTASAPSTghfKSFSDAAKPPGATPFKEEEKNP 140
Cdd:PHA03247 2746 AGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP--PRRLTRPAVASLSESRESL---PSPWDPADPPAAVLAPAAALPP 2820

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005  141 LAAPPLPKAQATSVIRHTADAQLCNHQSCPVKAASILNYQDnsFRRR----THGNVEATRKNIPCAAVS-PNRSKPEPST 215
Cdd:PHA03247 2821 AASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGD--VRRRppsrSPAAKPAAPARPPVRRLArPAVSRSTESF 2898

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575403005  216 VSDGDEKAGAALYDFAVPSSETVICRSQPAPSSPVQKSVLVSSPTVSTGGVPPLPVICQMVPLPANNSLVSTVVPS---- 291
Cdd:PHA03247 2899 ALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVprfr 2978


                  ....*..
gi 575403005  292 TPPSQPP 298
Cdd:PHA03247 2979 VPQPAPS 2985
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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