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Conserved domains on  [gi|577861077|ref|NP_001276743|]
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protein DGCR6 isoform 2 [Mus musculus]

Protein Classification

DUF2458 domain-containing protein( domain architecture ID 10538168)

DUF2458 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DGCR6 pfam07324
DiGeorge syndrome critical region 6 (DGCR6) protein; This family contains DiGeorge syndrome ...
2-195 3.13e-97

DiGeorge syndrome critical region 6 (DGCR6) protein; This family contains DiGeorge syndrome critical region 6 (DGCR6) proteins (approximately 200 residues long) of a number of vertebrates. DGCR6 is a candidate for involvement in the DiGeorge syndrome pathology by playing a role in neural crest cell migration into the third and fourth pharyngeal pouches, the structures from which derive the organs affected in DiGeorge syndrome. Also found in this family is the Drosophila melanogaster gonadal protein gdl.


:

Pssm-ID: 462145  Cd Length: 194  Bit Score: 280.16  E-value: 3.13e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861077    2 DRYAAAGDEAADRARQQERHYQLLSALQSLVKELPSSFQQRLSYTTLSDLALALLDGTVFEIVQGLLEIQHLTEKSLYNQ 81
Cdd:pfam07324   1 ERYTGAYEEAADSERQQERHYFLLSELQSLHKELPSSCQQRLSYTLLSDLALALLDGTVFEIVQGLLEIQHLTEKHLYNQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861077   82 RLRLQNEHRVLRQTLRQKHLEAQQSCRPHNLPVLQAAQQRELEAMEHRIREEQQAMDRKIVLELDRKVADQQSTLEKAGV 161
Cdd:pfam07324  81 RLKLENEHRALVQELRSKHKEAQQSCKPHNLPLLKAKQQRELEALEQRIREEQKMMDKKIVLELDQKVNDQQSTLEKAGV 160
                         170       180       190
                  ....*....|....*....|....*....|....
gi 577861077  162 AGFYVTTNPQELTLQMNLLELIRKLQQRGCQVGK 195
Cdd:pfam07324 161 PGFYVTTNPQELTIQMNLLDLILKLQQLKYEPNK 194
 
Name Accession Description Interval E-value
DGCR6 pfam07324
DiGeorge syndrome critical region 6 (DGCR6) protein; This family contains DiGeorge syndrome ...
2-195 3.13e-97

DiGeorge syndrome critical region 6 (DGCR6) protein; This family contains DiGeorge syndrome critical region 6 (DGCR6) proteins (approximately 200 residues long) of a number of vertebrates. DGCR6 is a candidate for involvement in the DiGeorge syndrome pathology by playing a role in neural crest cell migration into the third and fourth pharyngeal pouches, the structures from which derive the organs affected in DiGeorge syndrome. Also found in this family is the Drosophila melanogaster gonadal protein gdl.


Pssm-ID: 462145  Cd Length: 194  Bit Score: 280.16  E-value: 3.13e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861077    2 DRYAAAGDEAADRARQQERHYQLLSALQSLVKELPSSFQQRLSYTTLSDLALALLDGTVFEIVQGLLEIQHLTEKSLYNQ 81
Cdd:pfam07324   1 ERYTGAYEEAADSERQQERHYFLLSELQSLHKELPSSCQQRLSYTLLSDLALALLDGTVFEIVQGLLEIQHLTEKHLYNQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861077   82 RLRLQNEHRVLRQTLRQKHLEAQQSCRPHNLPVLQAAQQRELEAMEHRIREEQQAMDRKIVLELDRKVADQQSTLEKAGV 161
Cdd:pfam07324  81 RLKLENEHRALVQELRSKHKEAQQSCKPHNLPLLKAKQQRELEALEQRIREEQKMMDKKIVLELDQKVNDQQSTLEKAGV 160
                         170       180       190
                  ....*....|....*....|....*....|....
gi 577861077  162 AGFYVTTNPQELTLQMNLLELIRKLQQRGCQVGK 195
Cdd:pfam07324 161 PGFYVTTNPQELTIQMNLLDLILKLQQLKYEPNK 194
 
Name Accession Description Interval E-value
DGCR6 pfam07324
DiGeorge syndrome critical region 6 (DGCR6) protein; This family contains DiGeorge syndrome ...
2-195 3.13e-97

DiGeorge syndrome critical region 6 (DGCR6) protein; This family contains DiGeorge syndrome critical region 6 (DGCR6) proteins (approximately 200 residues long) of a number of vertebrates. DGCR6 is a candidate for involvement in the DiGeorge syndrome pathology by playing a role in neural crest cell migration into the third and fourth pharyngeal pouches, the structures from which derive the organs affected in DiGeorge syndrome. Also found in this family is the Drosophila melanogaster gonadal protein gdl.


Pssm-ID: 462145  Cd Length: 194  Bit Score: 280.16  E-value: 3.13e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861077    2 DRYAAAGDEAADRARQQERHYQLLSALQSLVKELPSSFQQRLSYTTLSDLALALLDGTVFEIVQGLLEIQHLTEKSLYNQ 81
Cdd:pfam07324   1 ERYTGAYEEAADSERQQERHYFLLSELQSLHKELPSSCQQRLSYTLLSDLALALLDGTVFEIVQGLLEIQHLTEKHLYNQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861077   82 RLRLQNEHRVLRQTLRQKHLEAQQSCRPHNLPVLQAAQQRELEAMEHRIREEQQAMDRKIVLELDRKVADQQSTLEKAGV 161
Cdd:pfam07324  81 RLKLENEHRALVQELRSKHKEAQQSCKPHNLPLLKAKQQRELEALEQRIREEQKMMDKKIVLELDQKVNDQQSTLEKAGV 160
                         170       180       190
                  ....*....|....*....|....*....|....
gi 577861077  162 AGFYVTTNPQELTLQMNLLELIRKLQQRGCQVGK 195
Cdd:pfam07324 161 PGFYVTTNPQELTIQMNLLDLILKLQQLKYEPNK 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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