|
Name |
Accession |
Description |
Interval |
E-value |
| Period_C |
pfam12114 |
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is ... |
1057-1159 |
9.43e-26 |
|
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.
Pssm-ID: 463464 Cd Length: 171 Bit Score: 105.18 E-value: 9.43e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 1057 SVYSSKISQNGQQSQDVQKKETF-PNVAEEPIWRMIRQTPERILMTYQVPERVKEVVLKEDLEKLESMRQQQPQFSHGQK 1135
Cdd:pfam12114 68 SIDSSENNHKAKKTAEVGEEEHFiKCVLQDPIWLLMANTDDSVMMTYQIPSRDLETVLKEDREKLKAMQKMQPRFTEDQK 147
|
90 100
....*....|....*....|....
gi 577861068 1136 EELAKVYNWIQSQTVTQEIDIQAC 1159
Cdd:pfam12114 148 GELAEVHPWIQKGGLPAALDLSEC 171
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
285-377 |
1.76e-12 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 64.58 E-value: 1.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 285 FLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEhspIRFCTQNGDYIILDSSWSSFVNPW 364
Cdd:cd00130 14 ILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLE---VRLRRKDGSVIWVLVSLTPIRDEG 90
|
90
....*....|...
gi 577861068 365 SRKISFIIGRHKV 377
Cdd:cd00130 91 GEVIGLLGVVRDI 103
|
|
| PAS_3 |
pfam08447 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
285-373 |
6.78e-12 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.
Pssm-ID: 430001 [Multi-domain] Cd Length: 89 Bit Score: 62.74 E-value: 6.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 285 FLEVDEKAVPLLGYLPQDLIGT--SILSYLHPEDRSLMVAIHQKVLKYAGhpPFEHsPIRFCTQNGDYIILDSSWSSFVN 362
Cdd:pfam08447 1 IIYWSPRFEEILGYTPEELLGKgeSWLDLVHPDDRERVREALWEALKGGE--PYSG-EYRIRRKDGEYRWVEARARPIRD 77
|
90
....*....|.
gi 577861068 363 pWSRKISFIIG 373
Cdd:pfam08447 78 -ENGKPVRVIG 87
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
285-329 |
1.22e-07 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 49.71 E-value: 1.22e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 577861068 285 FLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLK 329
Cdd:smart00091 23 ILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLLS 67
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
740-1035 |
9.46e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 50.32 E-value: 9.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 740 HKRKKLPEP-PDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPLPA-----ATSPGR 813
Cdd:PHA03247 2702 PPPPPTPEPaPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAppaapAAGPPR 2781
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 814 EYAAPGTAP--EGLHGLPLSEGLQPYPAFPFPYLDTFMTVFLPD----PPVCPLLSPSFLPCPFLGATASSAISPS---M 884
Cdd:PHA03247 2782 RLTRPAVASlsESRESLPSPWDPADPPAAVLAPAAALPPAASPAgplpPPTSAQPTAPPPPPGPPPPSLPLGGSVApggD 2861
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 885 SSAMSPTLDPPPSVTSQRREEEKWEAQSEghpfiTSRSSSPLQLNLLQEEMPRPSESPDQMRRNT--------------- 949
Cdd:PHA03247 2862 VRRRPPSRSPAAKPAAPARPPVRRLARPA-----VSRSTESFALPPDQPERPPQPQAPPPPQPQPqpppppqpqpppppp 2936
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 950 -------CPQTEYCVTGNNGSESSPATTGALSTGSPP----RENPSHPTASALSTGSPPMKNPSHPTASTLSMGLPPSRT 1018
Cdd:PHA03247 2937 prpqpplAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvprfRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEE 3016
|
330
....*....|....*..
gi 577861068 1019 PSHPTATVLSTGSPPSE 1035
Cdd:PHA03247 3017 TDPPPVSLKQTLWPPDD 3033
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
745-1038 |
6.33e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 43.99 E-value: 6.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 745 LPEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSP-HTSSPTFP-PAAMVPSQAPYLVPAFPLPAATSPGREYA-APGTA 821
Cdd:pfam03154 252 MTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPsHMQHPVPPqPFPLTPQSSQSQVPPGPSPAAPGQSQQRIhTPPSQ 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 822 PEGLHGLPLSEglQPYPAFPFPyldtfMTVFLPDP--PVCPLLSPSFLPCPflgatasSAISPSMSSAMSPTLDPPPSVt 899
Cdd:pfam03154 332 SQLQSQQPPRE--QPLPPAPLS-----MPHIKPPPttPIPQLPNPQSHKHP-------PHLSGPSPFQMNSNLPPPPAL- 396
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 900 sqrreeEKWEAQSEGHPfiTSRSSSPLQLNLLQEEMPRPSESPDQMRRntcpqteycvtgnngSESSPATTGalstgspp 979
Cdd:pfam03154 397 ------KPLSSLSTHHP--PSAHPPPLQLMPQSQQLPPPPAQPPVLTQ---------------SQSLPPPAA-------- 445
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 577861068 980 renpSHPTASALSTGSPPMKNPSHPTASTLSMGLPPSRTPSHPTATVLSTGSPPSESPS 1038
Cdd:pfam03154 446 ----SHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASV 500
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
274-374 |
3.17e-03 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 41.64 E-value: 3.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 274 IFTTTHTPGcVFLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEHSPIrfcTQNGDYIIL 353
Cdd:COG5805 169 LICVIDTDG-RILFINESIERLFGAPREELIGKNLLELLHPCDKEEFKERIESITEVWQEFIIEREII---TKDGRIRYF 244
|
90 100
....*....|....*....|..
gi 577861068 354 DSSWSSFVNP-WSRKISFIIGR 374
Cdd:COG5805 245 EAVIVPLIDTdGSVKGILVILR 266
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| Period_C |
pfam12114 |
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is ... |
1057-1159 |
9.43e-26 |
|
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.
Pssm-ID: 463464 Cd Length: 171 Bit Score: 105.18 E-value: 9.43e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 1057 SVYSSKISQNGQQSQDVQKKETF-PNVAEEPIWRMIRQTPERILMTYQVPERVKEVVLKEDLEKLESMRQQQPQFSHGQK 1135
Cdd:pfam12114 68 SIDSSENNHKAKKTAEVGEEEHFiKCVLQDPIWLLMANTDDSVMMTYQIPSRDLETVLKEDREKLKAMQKMQPRFTEDQK 147
|
90 100
....*....|....*....|....
gi 577861068 1136 EELAKVYNWIQSQTVTQEIDIQAC 1159
Cdd:pfam12114 148 GELAEVHPWIQKGGLPAALDLSEC 171
|
|
| PAS |
cd00130 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
285-377 |
1.76e-12 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.
Pssm-ID: 238075 [Multi-domain] Cd Length: 103 Bit Score: 64.58 E-value: 1.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 285 FLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEhspIRFCTQNGDYIILDSSWSSFVNPW 364
Cdd:cd00130 14 ILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLE---VRLRRKDGSVIWVLVSLTPIRDEG 90
|
90
....*....|...
gi 577861068 365 SRKISFIIGRHKV 377
Cdd:cd00130 91 GEVIGLLGVVRDI 103
|
|
| PAS_3 |
pfam08447 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
285-373 |
6.78e-12 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.
Pssm-ID: 430001 [Multi-domain] Cd Length: 89 Bit Score: 62.74 E-value: 6.78e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 285 FLEVDEKAVPLLGYLPQDLIGT--SILSYLHPEDRSLMVAIHQKVLKYAGhpPFEHsPIRFCTQNGDYIILDSSWSSFVN 362
Cdd:pfam08447 1 IIYWSPRFEEILGYTPEELLGKgeSWLDLVHPDDRERVREALWEALKGGE--PYSG-EYRIRRKDGEYRWVEARARPIRD 77
|
90
....*....|.
gi 577861068 363 pWSRKISFIIG 373
Cdd:pfam08447 78 -ENGKPVRVIG 87
|
|
| PAS_11 |
pfam14598 |
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ... |
275-377 |
3.03e-09 |
|
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).
Pssm-ID: 464214 [Multi-domain] Cd Length: 110 Bit Score: 55.76 E-value: 3.03e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 275 FTTTHTPGCVFLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHppfEHSPI-RFCTQNGDYIIL 353
Cdd:pfam14598 4 FTTRHDIDGKIISCDTRAPFSLGYEKDELVGRSIYDLVHPQDLRTAKSHLREIIQTRGR---ATSPSyRLRLRDGDFLSV 80
|
90 100
....*....|....*....|....
gi 577861068 354 DSSWSSFVNPWSRKISFIIGRHKV 377
Cdd:pfam14598 81 HTKSKLFLNQNSNQQPFIMCTHTI 104
|
|
| PAS |
pfam00989 |
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ... |
272-371 |
3.79e-09 |
|
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
Pssm-ID: 395786 [Multi-domain] Cd Length: 113 Bit Score: 55.50 E-value: 3.79e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 272 KRIFTTTHTPGCV------FLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKyAGHPPFEHSpIRFCT 345
Cdd:pfam00989 4 RAILESLPDGIFVvdedgrILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLRQALL-QGEESRGFE-VSFRV 81
|
90 100
....*....|....*....|....*.
gi 577861068 346 QNGDYIILDSSWSSFVNPWSRKISFI 371
Cdd:pfam00989 82 PDGRPRHVEVRASPVRDAGGEILGFL 107
|
|
| PAS |
smart00091 |
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ... |
285-329 |
1.22e-07 |
|
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.
Pssm-ID: 214512 Cd Length: 67 Bit Score: 49.71 E-value: 1.22e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 577861068 285 FLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLK 329
Cdd:smart00091 23 ILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLLS 67
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
740-1035 |
9.46e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 50.32 E-value: 9.46e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 740 HKRKKLPEP-PDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPLPA-----ATSPGR 813
Cdd:PHA03247 2702 PPPPPTPEPaPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAppaapAAGPPR 2781
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 814 EYAAPGTAP--EGLHGLPLSEGLQPYPAFPFPYLDTFMTVFLPD----PPVCPLLSPSFLPCPFLGATASSAISPS---M 884
Cdd:PHA03247 2782 RLTRPAVASlsESRESLPSPWDPADPPAAVLAPAAALPPAASPAgplpPPTSAQPTAPPPPPGPPPPSLPLGGSVApggD 2861
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 885 SSAMSPTLDPPPSVTSQRREEEKWEAQSEghpfiTSRSSSPLQLNLLQEEMPRPSESPDQMRRNT--------------- 949
Cdd:PHA03247 2862 VRRRPPSRSPAAKPAAPARPPVRRLARPA-----VSRSTESFALPPDQPERPPQPQAPPPPQPQPqpppppqpqpppppp 2936
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 950 -------CPQTEYCVTGNNGSESSPATTGALSTGSPP----RENPSHPTASALSTGSPPMKNPSHPTASTLSMGLPPSRT 1018
Cdd:PHA03247 2937 prpqpplAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvprfRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEE 3016
|
330
....*....|....*..
gi 577861068 1019 PSHPTATVLSTGSPPSE 1035
Cdd:PHA03247 3017 TDPPPVSLKQTLWPPDD 3033
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
746-1040 |
1.19e-05 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 49.78 E-value: 1.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 746 PEPPDSSSSNTGSGPRRGAHQNAQPCC-PSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPL-PAATSPGREYAAPGTAPE 823
Cdd:PHA03307 80 PANESRSTPTWSLSTLAPASPAREGSPtPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPvGSPGPPPAASPPAAGASP 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 824 GLHGLPLSEGLQPYPAFPfpyldtfMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSAMsptldPPPSVTSQRR 903
Cdd:PHA03307 160 AAVASDAASSRQAALPLS-------SPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASA-----SSPAPAPGRS 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 904 EEEKWEAQSEGhpfiTSRSSSPLQLNLLQEEMPRPSESPDqmRRNTCPQTEycVTGNN-GSESSPATTGALSTGSPPREN 982
Cdd:PHA03307 228 AADDAGASSSD----SSSSESSGCGWGPENECPLPRPAPI--TLPTRIWEA--SGWNGpSSRPGPASSSSSPRERSPSPS 299
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 577861068 983 PSHPTASALSTGSPPMKNPSHPTASTLSmglppSRTPSHPTATVLSTGSPPSESPSRT 1040
Cdd:PHA03307 300 PSSPGSGPAPSSPRASSSSSSSRESSSS-----STSSSSESSRGAAVSPGPSPSRSPS 352
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
746-1040 |
3.00e-05 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 48.63 E-value: 3.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 746 PEPPDSSSSNTGSGPRRG-AHQNAQPCCPSAASSPHTSSPtFPPAAMVPSQAPYLVPAFPLPAATSPGREYAAPGTAPEG 824
Cdd:PHA03307 114 PDPPPPTPPPASPPPSPApDLSEMLRPVGSPGPPPAASPP-AAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAE 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 825 LHGLPLSEGLQPYPafpfPYLDTFMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSAMSPTLDPPPS---VTSQ 901
Cdd:PHA03307 193 PPPSTPPAAASPRP----PRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPApitLPTR 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 902 RREEEKWEAQSEGHPFITSRSSSPlqlnllqEEMPRPSESPDQMRRNTCPQTeycVTGNNGSESSPATTGALSTGSPPRE 981
Cdd:PHA03307 269 IWEASGWNGPSSRPGPASSSSSPR-------ERSPSPSPSSPGSGPAPSSPR---ASSSSSSSRESSSSSTSSSSESSRG 338
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 982 NPSHPTAS-----ALSTGSPPMKNPSHPTASTLSMGlPPSRTPSHPTATVLSTGS------PPSESPSRT 1040
Cdd:PHA03307 339 AAVSPGPSpsrspSPSRPPPPADPSSPRKRPRPSRA-PSSPAASAGRPTRRRARAavagraRRRDATGRF 407
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
775-1038 |
2.10e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 45.70 E-value: 2.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 775 AASSPHTSSPTFPPAA---MVPSQAPylVPAFPLPAATSPGREYAAP-----GTAPEGLHGLPLSeglqPYPAFPFPyld 846
Cdd:PHA03247 2548 AGDPPPPLPPAAPPAApdrSVPPPRP--APRPSEPAVTSRARRPDAPpqsarPRAPVDDRGDPRG----PAPPSPLP--- 2618
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 847 tfmtvflPDPPvcPLLSPSFLPCPFLGATASSAISPSMSSAMSPTLDPPPSVTSQRReeekweAQSEGHPfitSRSSSPL 926
Cdd:PHA03247 2619 -------PDTH--APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRR------ARRLGRA---AQASSPP 2680
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 927 Q-------------LNLLQEEmPRPSESPDQMRRNTCPQTEYCVTGNNGSESSPATTGALSTGSPPrENPSHPTASALST 993
Cdd:PHA03247 2681 QrprrraarptvgsLTSLADP-PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPARPA 2758
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 577861068 994 GSPPMKNPSHPTASTLSMGLPPSRTPShPTATVLSTGSPPSESPS 1038
Cdd:PHA03247 2759 RPPTTAGPPAPAPPAAPAAGPPRRLTR-PAVASLSESRESLPSPW 2802
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
746-1040 |
2.50e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 45.55 E-value: 2.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 746 PEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPLPAATSPGREYAAPGTAPEGL 825
Cdd:PHA03307 129 SPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPR 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 826 HGLPLSEG-LQPYPAFP----FPYLDTFMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSAMSPTLDPPP--SV 898
Cdd:PHA03307 209 RSSPISASaSSPAPAPGrsaaDDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPasSS 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 899 TSQRREEEKWEAQSEGHPFITSRSSSplqlnlLQEEMPRPSESPDQMRRntcpqteycvtGNNGSESSPATTGALSTGSP 978
Cdd:PHA03307 289 SSPRERSPSPSPSSPGSGPAPSSPRA------SSSSSSSRESSSSSTSS-----------SSESSRGAAVSPGPSPSRSP 351
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 577861068 979 PRENPSHP-TASALSTGSPPMKNPSHPTAStlsmglPPSRTPSHPTATVLSTGSPPSESPSRT 1040
Cdd:PHA03307 352 SPSRPPPPaDPSSPRKRPRPSRAPSSPAAS------AGRPTRRRARAAVAGRARRRDATGRFP 408
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
745-1038 |
6.33e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 43.99 E-value: 6.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 745 LPEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSP-HTSSPTFP-PAAMVPSQAPYLVPAFPLPAATSPGREYA-APGTA 821
Cdd:pfam03154 252 MTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPsHMQHPVPPqPFPLTPQSSQSQVPPGPSPAAPGQSQQRIhTPPSQ 331
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 822 PEGLHGLPLSEglQPYPAFPFPyldtfMTVFLPDP--PVCPLLSPSFLPCPflgatasSAISPSMSSAMSPTLDPPPSVt 899
Cdd:pfam03154 332 SQLQSQQPPRE--QPLPPAPLS-----MPHIKPPPttPIPQLPNPQSHKHP-------PHLSGPSPFQMNSNLPPPPAL- 396
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 900 sqrreeEKWEAQSEGHPfiTSRSSSPLQLNLLQEEMPRPSESPDQMRRntcpqteycvtgnngSESSPATTGalstgspp 979
Cdd:pfam03154 397 ------KPLSSLSTHHP--PSAHPPPLQLMPQSQQLPPPPAQPPVLTQ---------------SQSLPPPAA-------- 445
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 577861068 980 renpSHPTASALSTGSPPMKNPSHPTASTLSMGLPPSRTPSHPTATVLSTGSPPSESPS 1038
Cdd:pfam03154 446 ----SHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASV 500
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
745-1038 |
6.66e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.16 E-value: 6.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 745 LPEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSP-------HTSSPTFPPAAMVPSQAPYLVPAFPLPAATSPGREYAA 817
Cdd:PHA03247 2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPP 2703
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 818 PGTAPE-----GLHGLPLSEGLQPYPAFPFPYLDTFMTVFLPDPPVCPlLSPSFLPCPFLGATASSAISPSMSSAMSPTL 892
Cdd:PHA03247 2704 PPPTPEpaphaLVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP-GGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 893 DPPPSVTSQRREEEK----WEAQSEGHPFITSRSSSPLQLNLLQEEMPRPSESPDQMRRNTCPQTEYCVTGnngseSSPA 968
Cdd:PHA03247 2783 LTRPAVASLSESRESlpspWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG-----GSVA 2857
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 577861068 969 TTGALSTGSPPRENPSHPTASAlstgSPPMKNPSHP--TASTLSMGLPPS-----RTPSHPTATVLSTGSPPSESPS 1038
Cdd:PHA03247 2858 PGGDVRRRPPSRSPAAKPAAPA----RPPVRRLARPavSRSTESFALPPDqperpPQPQAPPPPQPQPQPPPPPQPQ 2930
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
748-1038 |
8.57e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.77 E-value: 8.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 748 PPDSSSSNTGSGPRRGAHQNAQPccpsAASSPHTSSPTFPPAAmvPSQAPYLVPAFPLPAATSPGREYAAPGTAPEGLHG 827
Cdd:PHA03247 2592 PPQSARPRAPVDDRGDPRGPAPP----SPLPPDTHAPDPPPPS--PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPR 2665
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 828 LPLSEGLQPYPAFPF---------PYLDTFMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSAMSPTLDPPPSV 898
Cdd:PHA03247 2666 RARRLGRAAQASSPPqrprrraarPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVP 2745
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 899 TSQRREEEKWEAQSEGHPFITSRSSSP-LQLNLLQEEMPRPSESPDQMRRNTCPQTEycvTGNNGSESSPATTGALSTGS 977
Cdd:PHA03247 2746 AGPATPGGPARPARPPTTAGPPAPAPPaAPAAGPPRRLTRPAVASLSESRESLPSPW---DPADPPAAVLAPAAALPPAA 2822
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 577861068 978 PPrENPSHPTASALSTGSPPmknPSHPTASTLSMG-----------LPPSR-------TPSHPTATVLSTGSPPSESPS 1038
Cdd:PHA03247 2823 SP-AGPLPPPTSAQPTAPPP---PPGPPPPSLPLGgsvapggdvrrRPPSRspaakpaAPARPPVRRLARPAVSRSTES 2897
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
696-1039 |
2.09e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 42.62 E-value: 2.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 696 REKILSSPYSSYLQQESRSKAKYSYFQGDSTSKQTRSAGCRKGKHKRKKLPEPPDSSSSntgSGPRRGAHQNAQPCCPSA 775
Cdd:PHA03247 2649 PERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPT---PEPAPHALVSATPLPPGP 2725
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 776 ASSPHTSSPtfPPAAMVPSQAPY--LVPAFPLPAATSPGREYAAPGTAPEGLHGLPLSEGLQPYPAFPFPYLDTFMTVFL 853
Cdd:PHA03247 2726 AAARQASPA--LPAAPAPPAVPAgpATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 854 PDPPVCPLLSP-SFLPCPFLGATASSAISPSMSSAMSPTLDPPPSVTS-----------QRReeekweAQSEGHPFITSR 921
Cdd:PHA03247 2804 PADPPAAVLAPaAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPlggsvapggdvRRR------PPSRSPAAKPAA 2877
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 922 SSSPLQLNLLQEEMPRPSES----PDQMRRNTCPQTEYCVTGNNGSESSPATTGALSTgsPPR-ENPSHPTASALSTGSP 996
Cdd:PHA03247 2878 PARPPVRRLARPAVSRSTESfalpPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP--PPRpQPPLAPTTDPAGAGEP 2955
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 577861068 997 PMKNPSHPTASTLSMGLPPSRTPSHPTATVLSTGSPPSESPSR 1039
Cdd:PHA03247 2956 SGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTG 2998
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
274-374 |
3.17e-03 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 41.64 E-value: 3.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 274 IFTTTHTPGcVFLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEHSPIrfcTQNGDYIIL 353
Cdd:COG5805 169 LICVIDTDG-RILFINESIERLFGAPREELIGKNLLELLHPCDKEEFKERIESITEVWQEFIIEREII---TKDGRIRYF 244
|
90 100
....*....|....*....|..
gi 577861068 354 DSSWSSFVNP-WSRKISFIIGR 374
Cdd:COG5805 245 EAVIVPLIDTdGSVKGILVILR 266
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
752-1014 |
4.53e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 41.01 E-value: 4.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 752 SSSNTGSGPRRGAHQN-AQPCCPSAASSPHTSSPTFPPA--AMVPSQAPYLVPAFPLPAATSPGREYAAPGTAPEGLHGL 828
Cdd:PRK12323 366 GQSGGGAGPATAAAAPvAQPAPAAAAPAAAAPAPAAPPAapAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPG 445
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 829 PLSEGLQPYPAFPFPyldtfmtvfLPDPPVCPLLSPSFLpcpflgATASSAISPSMSSAMSPTLDPPPsvtsqrreeekW 908
Cdd:PRK12323 446 GAPAPAPAPAAAPAA---------AARPAAAGPRPVAAA------AAAAPARAAPAAAPAPADDDPPP-----------W 499
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068 909 EAQSEGHPFITSRSSSPLQLNLLQEEMPRPSESPDQMRRNTCPQteycvtgnngsESSPATTGALSTGSPPRENPSHPTA 988
Cdd:PRK12323 500 EELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAP-----------APAAAPAPRAAAATEPVVAPRPPRA 568
|
250 260
....*....|....*....|....*.
gi 577861068 989 SAlsTGSPPMKNPSHPtasTLSMGLP 1014
Cdd:PRK12323 569 SA--SGLPDMFDGDWP---ALAARLP 589
|
|
|