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Conserved domains on  [gi|577861068|ref|NP_001276792|]
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period circadian protein homolog 3 isoform 3 [Homo sapiens]

Protein Classification

PAS and Period_C domain-containing protein( domain architecture ID 10063729)

PAS and Period_C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Period_C super family cl13540
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is ...
 1057-1159 9.43e-26

Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.


The actual alignment was detected with superfamily member pfam12114:

Pssm-ID: 463464  Cd Length: 171  Bit Score: 105.18  E-value: 9.43e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  1057 SVYSSKISQNGQQSQDVQKKETF-PNVAEEPIWRMIRQTPERILMTYQVPERVKEVVLKEDLEKLESMRQQQPQFSHGQK 1135
Cdd:pfam12114   68 SIDSSENNHKAKKTAEVGEEEHFiKCVLQDPIWLLMANTDDSVMMTYQIPSRDLETVLKEDREKLKAMQKMQPRFTEDQK 147

                           90       100
                   ....*....|....*....|....
gi 577861068  1136 EELAKVYNWIQSQTVTQEIDIQAC 1159
Cdd:pfam12114  148 GELAEVHPWIQKGGLPAALDLSEC 171
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 285-377 1.76e-12

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


:

Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 64.58  E-value: 1.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  285 FLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEhspIRFCTQNGDYIILDSSWSSFVNPW 364
Cdd:cd00130    14 ILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLE---VRLRRKDGSVIWVLVSLTPIRDEG 90

                          90
                  ....*....|...
gi 577861068  365 SRKISFIIGRHKV 377
Cdd:cd00130    91 GEVIGLLGVVRDI 103
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 740-1035 9.46e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 9.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  740 HKRKKLPEP-PDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPLPA-----ATSPGR 813
Cdd:PHA03247 2702 PPPPPTPEPaPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAppaapAAGPPR 2781

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  814 EYAAPGTAP--EGLHGLPLSEGLQPYPAFPFPYLDTFMTVFLPD----PPVCPLLSPSFLPCPFLGATASSAISPS---M 884
Cdd:PHA03247 2782 RLTRPAVASlsESRESLPSPWDPADPPAAVLAPAAALPPAASPAgplpPPTSAQPTAPPPPPGPPPPSLPLGGSVApggD 2861

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  885 SSAMSPTLDPPPSVTSQRREEEKWEAQSEghpfiTSRSSSPLQLNLLQEEMPRPSESPDQMRRNT--------------- 949
Cdd:PHA03247 2862 VRRRPPSRSPAAKPAAPARPPVRRLARPA-----VSRSTESFALPPDQPERPPQPQAPPPPQPQPqpppppqpqpppppp 2936

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  950 -------CPQTEYCVTGNNGSESSPATTGALSTGSPP----RENPSHPTASALSTGSPPMKNPSHPTASTLSMGLPPSRT 1018
Cdd:PHA03247 2937 prpqpplAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvprfRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEE 3016

                         330
                  ....*....|....*..
gi 577861068 1019 PSHPTATVLSTGSPPSE 1035
Cdd:PHA03247 3017 TDPPPVSLKQTLWPPDD 3033
 
Name Accession Description Interval E-value
Period_C pfam12114
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is ...
 1057-1159 9.43e-26

Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.


Pssm-ID: 463464  Cd Length: 171  Bit Score: 105.18  E-value: 9.43e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  1057 SVYSSKISQNGQQSQDVQKKETF-PNVAEEPIWRMIRQTPERILMTYQVPERVKEVVLKEDLEKLESMRQQQPQFSHGQK 1135
Cdd:pfam12114   68 SIDSSENNHKAKKTAEVGEEEHFiKCVLQDPIWLLMANTDDSVMMTYQIPSRDLETVLKEDREKLKAMQKMQPRFTEDQK 147

                           90       100
                   ....*....|....*....|....
gi 577861068  1136 EELAKVYNWIQSQTVTQEIDIQAC 1159
Cdd:pfam12114  148 GELAEVHPWIQKGGLPAALDLSEC 171
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 285-377 1.76e-12

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 64.58  E-value: 1.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  285 FLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEhspIRFCTQNGDYIILDSSWSSFVNPW 364
Cdd:cd00130    14 ILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLE---VRLRRKDGSVIWVLVSLTPIRDEG 90

                          90
                  ....*....|...
gi 577861068  365 SRKISFIIGRHKV 377
Cdd:cd00130    91 GEVIGLLGVVRDI 103
PAS_3 pfam08447
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 285-373 6.78e-12

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


Pssm-ID: 430001 [Multi-domain]  Cd Length: 89  Bit Score: 62.74  E-value: 6.78e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068   285 FLEVDEKAVPLLGYLPQDLIGT--SILSYLHPEDRSLMVAIHQKVLKYAGhpPFEHsPIRFCTQNGDYIILDSSWSSFVN 362
Cdd:pfam08447    1 IIYWSPRFEEILGYTPEELLGKgeSWLDLVHPDDRERVREALWEALKGGE--PYSG-EYRIRRKDGEYRWVEARARPIRD 77

                           90
                   ....*....|.
gi 577861068   363 pWSRKISFIIG 373
Cdd:pfam08447   78 -ENGKPVRVIG 87
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 285-329 1.22e-07

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 49.71  E-value: 1.22e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 577861068    285 FLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLK 329
Cdd:smart00091   23 ILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLLS 67
PHA03247 PHA03247
large tegument protein UL36; Provisional
 740-1035 9.46e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 9.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  740 HKRKKLPEP-PDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPLPA-----ATSPGR 813
Cdd:PHA03247 2702 PPPPPTPEPaPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAppaapAAGPPR 2781

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  814 EYAAPGTAP--EGLHGLPLSEGLQPYPAFPFPYLDTFMTVFLPD----PPVCPLLSPSFLPCPFLGATASSAISPS---M 884
Cdd:PHA03247 2782 RLTRPAVASlsESRESLPSPWDPADPPAAVLAPAAALPPAASPAgplpPPTSAQPTAPPPPPGPPPPSLPLGGSVApggD 2861

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  885 SSAMSPTLDPPPSVTSQRREEEKWEAQSEghpfiTSRSSSPLQLNLLQEEMPRPSESPDQMRRNT--------------- 949
Cdd:PHA03247 2862 VRRRPPSRSPAAKPAAPARPPVRRLARPA-----VSRSTESFALPPDQPERPPQPQAPPPPQPQPqpppppqpqpppppp 2936

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  950 -------CPQTEYCVTGNNGSESSPATTGALSTGSPP----RENPSHPTASALSTGSPPMKNPSHPTASTLSMGLPPSRT 1018
Cdd:PHA03247 2937 prpqpplAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvprfRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEE 3016

                         330
                  ....*....|....*..
gi 577861068 1019 PSHPTATVLSTGSPPSE 1035
Cdd:PHA03247 3017 TDPPPVSLKQTLWPPDD 3033
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 745-1038 6.33e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.99  E-value: 6.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068   745 LPEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSP-HTSSPTFP-PAAMVPSQAPYLVPAFPLPAATSPGREYA-APGTA 821
Cdd:pfam03154  252 MTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPsHMQHPVPPqPFPLTPQSSQSQVPPGPSPAAPGQSQQRIhTPPSQ 331

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068   822 PEGLHGLPLSEglQPYPAFPFPyldtfMTVFLPDP--PVCPLLSPSFLPCPflgatasSAISPSMSSAMSPTLDPPPSVt 899
Cdd:pfam03154  332 SQLQSQQPPRE--QPLPPAPLS-----MPHIKPPPttPIPQLPNPQSHKHP-------PHLSGPSPFQMNSNLPPPPAL- 396

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068   900 sqrreeEKWEAQSEGHPfiTSRSSSPLQLNLLQEEMPRPSESPDQMRRntcpqteycvtgnngSESSPATTGalstgspp 979
Cdd:pfam03154  397 ------KPLSSLSTHHP--PSAHPPPLQLMPQSQQLPPPPAQPPVLTQ---------------SQSLPPPAA-------- 445

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 577861068   980 renpSHPTASALSTGSPPMKNPSHPTASTLSMGLPPSRTPSHPTATVLSTGSPPSESPS 1038
Cdd:pfam03154  446 ----SHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASV 500
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 274-374 3.17e-03

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 41.64  E-value: 3.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  274 IFTTTHTPGcVFLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEHSPIrfcTQNGDYIIL 353
Cdd:COG5805   169 LICVIDTDG-RILFINESIERLFGAPREELIGKNLLELLHPCDKEEFKERIESITEVWQEFIIEREII---TKDGRIRYF 244

                          90       100
                  ....*....|....*....|..
gi 577861068  354 DSSWSSFVNP-WSRKISFIIGR 374
Cdd:COG5805   245 EAVIVPLIDTdGSVKGILVILR 266
 
Name Accession Description Interval E-value
Period_C pfam12114
Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is ...
 1057-1159 9.43e-26

Period protein 2/3C-terminal region; This domain is found in eukaryotes. This domain is typically between 164 to 200 amino acids in length. This domain is found associated with pfam08447.


Pssm-ID: 463464  Cd Length: 171  Bit Score: 105.18  E-value: 9.43e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  1057 SVYSSKISQNGQQSQDVQKKETF-PNVAEEPIWRMIRQTPERILMTYQVPERVKEVVLKEDLEKLESMRQQQPQFSHGQK 1135
Cdd:pfam12114   68 SIDSSENNHKAKKTAEVGEEEHFiKCVLQDPIWLLMANTDDSVMMTYQIPSRDLETVLKEDREKLKAMQKMQPRFTEDQK 147

                           90       100
                   ....*....|....*....|....
gi 577861068  1136 EELAKVYNWIQSQTVTQEIDIQAC 1159
Cdd:pfam12114  148 GELAEVHPWIQKGGLPAALDLSEC 171
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 285-377 1.76e-12

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 64.58  E-value: 1.76e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  285 FLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEhspIRFCTQNGDYIILDSSWSSFVNPW 364
Cdd:cd00130    14 ILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPVTLE---VRLRRKDGSVIWVLVSLTPIRDEG 90

                          90
                  ....*....|...
gi 577861068  365 SRKISFIIGRHKV 377
Cdd:cd00130    91 GEVIGLLGVVRDI 103
PAS_3 pfam08447
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 285-373 6.78e-12

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


Pssm-ID: 430001 [Multi-domain]  Cd Length: 89  Bit Score: 62.74  E-value: 6.78e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068   285 FLEVDEKAVPLLGYLPQDLIGT--SILSYLHPEDRSLMVAIHQKVLKYAGhpPFEHsPIRFCTQNGDYIILDSSWSSFVN 362
Cdd:pfam08447    1 IIYWSPRFEEILGYTPEELLGKgeSWLDLVHPDDRERVREALWEALKGGE--PYSG-EYRIRRKDGEYRWVEARARPIRD 77

                           90
                   ....*....|.
gi 577861068   363 pWSRKISFIIG 373
Cdd:pfam08447   78 -ENGKPVRVIG 87
PAS_11 pfam14598
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 275-377 3.03e-09

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 55.76  E-value: 3.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068   275 FTTTHTPGCVFLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHppfEHSPI-RFCTQNGDYIIL 353
Cdd:pfam14598    4 FTTRHDIDGKIISCDTRAPFSLGYEKDELVGRSIYDLVHPQDLRTAKSHLREIIQTRGR---ATSPSyRLRLRDGDFLSV 80

                           90       100
                   ....*....|....*....|....
gi 577861068   354 DSSWSSFVNPWSRKISFIIGRHKV 377
Cdd:pfam14598   81 HTKSKLFLNQNSNQQPFIMCTHTI 104
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 272-371 3.79e-09

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 55.50  E-value: 3.79e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068   272 KRIFTTTHTPGCV------FLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKyAGHPPFEHSpIRFCT 345
Cdd:pfam00989    4 RAILESLPDGIFVvdedgrILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLRQALL-QGEESRGFE-VSFRV 81

                           90       100
                   ....*....|....*....|....*.
gi 577861068   346 QNGDYIILDSSWSSFVNPWSRKISFI 371
Cdd:pfam00989   82 PDGRPRHVEVRASPVRDAGGEILGFL 107
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 285-329 1.22e-07

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 49.71  E-value: 1.22e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 577861068    285 FLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLK 329
Cdd:smart00091   23 ILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLLS 67
PHA03247 PHA03247
large tegument protein UL36; Provisional
 740-1035 9.46e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 9.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  740 HKRKKLPEP-PDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPLPA-----ATSPGR 813
Cdd:PHA03247 2702 PPPPPTPEPaPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAppaapAAGPPR 2781

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  814 EYAAPGTAP--EGLHGLPLSEGLQPYPAFPFPYLDTFMTVFLPD----PPVCPLLSPSFLPCPFLGATASSAISPS---M 884
Cdd:PHA03247 2782 RLTRPAVASlsESRESLPSPWDPADPPAAVLAPAAALPPAASPAgplpPPTSAQPTAPPPPPGPPPPSLPLGGSVApggD 2861

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  885 SSAMSPTLDPPPSVTSQRREEEKWEAQSEghpfiTSRSSSPLQLNLLQEEMPRPSESPDQMRRNT--------------- 949
Cdd:PHA03247 2862 VRRRPPSRSPAAKPAAPARPPVRRLARPA-----VSRSTESFALPPDQPERPPQPQAPPPPQPQPqpppppqpqpppppp 2936

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  950 -------CPQTEYCVTGNNGSESSPATTGALSTGSPP----RENPSHPTASALSTGSPPMKNPSHPTASTLSMGLPPSRT 1018
Cdd:PHA03247 2937 prpqpplAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvprfRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEE 3016

                         330
                  ....*....|....*..
gi 577861068 1019 PSHPTATVLSTGSPPSE 1035
Cdd:PHA03247 3017 TDPPPVSLKQTLWPPDD 3033
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 746-1040 1.19e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.78  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  746 PEPPDSSSSNTGSGPRRGAHQNAQPCC-PSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPL-PAATSPGREYAAPGTAPE 823
Cdd:PHA03307   80 PANESRSTPTWSLSTLAPASPAREGSPtPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPvGSPGPPPAASPPAAGASP 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  824 GLHGLPLSEGLQPYPAFPfpyldtfMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSAMsptldPPPSVTSQRR 903
Cdd:PHA03307  160 AAVASDAASSRQAALPLS-------SPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASA-----SSPAPAPGRS 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  904 EEEKWEAQSEGhpfiTSRSSSPLQLNLLQEEMPRPSESPDqmRRNTCPQTEycVTGNN-GSESSPATTGALSTGSPPREN 982
Cdd:PHA03307  228 AADDAGASSSD----SSSSESSGCGWGPENECPLPRPAPI--TLPTRIWEA--SGWNGpSSRPGPASSSSSPRERSPSPS 299

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 577861068  983 PSHPTASALSTGSPPMKNPSHPTASTLSmglppSRTPSHPTATVLSTGSPPSESPSRT 1040
Cdd:PHA03307  300 PSSPGSGPAPSSPRASSSSSSSRESSSS-----STSSSSESSRGAAVSPGPSPSRSPS 352
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 746-1040 3.00e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 48.63  E-value: 3.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  746 PEPPDSSSSNTGSGPRRG-AHQNAQPCCPSAASSPHTSSPtFPPAAMVPSQAPYLVPAFPLPAATSPGREYAAPGTAPEG 824
Cdd:PHA03307  114 PDPPPPTPPPASPPPSPApDLSEMLRPVGSPGPPPAASPP-AAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAE 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  825 LHGLPLSEGLQPYPafpfPYLDTFMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSAMSPTLDPPPS---VTSQ 901
Cdd:PHA03307  193 PPPSTPPAAASPRP----PRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPApitLPTR 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  902 RREEEKWEAQSEGHPFITSRSSSPlqlnllqEEMPRPSESPDQMRRNTCPQTeycVTGNNGSESSPATTGALSTGSPPRE 981
Cdd:PHA03307  269 IWEASGWNGPSSRPGPASSSSSPR-------ERSPSPSPSSPGSGPAPSSPR---ASSSSSSSRESSSSSTSSSSESSRG 338

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  982 NPSHPTAS-----ALSTGSPPMKNPSHPTASTLSMGlPPSRTPSHPTATVLSTGS------PPSESPSRT 1040
Cdd:PHA03307  339 AAVSPGPSpsrspSPSRPPPPADPSSPRKRPRPSRA-PSSPAASAGRPTRRRARAavagraRRRDATGRF 407
PHA03247 PHA03247
large tegument protein UL36; Provisional
 775-1038 2.10e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 2.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  775 AASSPHTSSPTFPPAA---MVPSQAPylVPAFPLPAATSPGREYAAP-----GTAPEGLHGLPLSeglqPYPAFPFPyld 846
Cdd:PHA03247 2548 AGDPPPPLPPAAPPAApdrSVPPPRP--APRPSEPAVTSRARRPDAPpqsarPRAPVDDRGDPRG----PAPPSPLP--- 2618

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  847 tfmtvflPDPPvcPLLSPSFLPCPFLGATASSAISPSMSSAMSPTLDPPPSVTSQRReeekweAQSEGHPfitSRSSSPL 926
Cdd:PHA03247 2619 -------PDTH--APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRR------ARRLGRA---AQASSPP 2680

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  927 Q-------------LNLLQEEmPRPSESPDQMRRNTCPQTEYCVTGNNGSESSPATTGALSTGSPPrENPSHPTASALST 993
Cdd:PHA03247 2681 QrprrraarptvgsLTSLADP-PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVP-AGPATPGGPARPA 2758

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 577861068  994 GSPPMKNPSHPTASTLSMGLPPSRTPShPTATVLSTGSPPSESPS 1038
Cdd:PHA03247 2759 RPPTTAGPPAPAPPAAPAAGPPRRLTR-PAVASLSESRESLPSPW 2802
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 746-1040 2.50e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.55  E-value: 2.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  746 PEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSPHTSSPTFPPAAMVPSQAPYLVPAFPLPAATSPGREYAAPGTAPEGL 825
Cdd:PHA03307  129 SPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPR 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  826 HGLPLSEG-LQPYPAFP----FPYLDTFMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSAMSPTLDPPP--SV 898
Cdd:PHA03307  209 RSSPISASaSSPAPAPGrsaaDDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPasSS 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  899 TSQRREEEKWEAQSEGHPFITSRSSSplqlnlLQEEMPRPSESPDQMRRntcpqteycvtGNNGSESSPATTGALSTGSP 978
Cdd:PHA03307  289 SSPRERSPSPSPSSPGSGPAPSSPRA------SSSSSSSRESSSSSTSS-----------SSESSRGAAVSPGPSPSRSP 351

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 577861068  979 PRENPSHP-TASALSTGSPPMKNPSHPTAStlsmglPPSRTPSHPTATVLSTGSPPSESPSRT 1040
Cdd:PHA03307  352 SPSRPPPPaDPSSPRKRPRPSRAPSSPAAS------AGRPTRRRARAAVAGRARRRDATGRFP 408
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 745-1038 6.33e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.99  E-value: 6.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068   745 LPEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSP-HTSSPTFP-PAAMVPSQAPYLVPAFPLPAATSPGREYA-APGTA 821
Cdd:pfam03154  252 MTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPsHMQHPVPPqPFPLTPQSSQSQVPPGPSPAAPGQSQQRIhTPPSQ 331

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068   822 PEGLHGLPLSEglQPYPAFPFPyldtfMTVFLPDP--PVCPLLSPSFLPCPflgatasSAISPSMSSAMSPTLDPPPSVt 899
Cdd:pfam03154  332 SQLQSQQPPRE--QPLPPAPLS-----MPHIKPPPttPIPQLPNPQSHKHP-------PHLSGPSPFQMNSNLPPPPAL- 396

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068   900 sqrreeEKWEAQSEGHPfiTSRSSSPLQLNLLQEEMPRPSESPDQMRRntcpqteycvtgnngSESSPATTGalstgspp 979
Cdd:pfam03154  397 ------KPLSSLSTHHP--PSAHPPPLQLMPQSQQLPPPPAQPPVLTQ---------------SQSLPPPAA-------- 445

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 577861068   980 renpSHPTASALSTGSPPMKNPSHPTASTLSMGLPPSRTPSHPTATVLSTGSPPSESPS 1038
Cdd:pfam03154  446 ----SHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASV 500
PHA03247 PHA03247
large tegument protein UL36; Provisional
 745-1038 6.66e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 6.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  745 LPEPPDSSSSNTGSGPRRGAHQNAQPCCPSAASSP-------HTSSPTFPPAAMVPSQAPYLVPAFPLPAATSPGREYAA 817
Cdd:PHA03247 2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPP 2703

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  818 PGTAPE-----GLHGLPLSEGLQPYPAFPFPYLDTFMTVFLPDPPVCPlLSPSFLPCPFLGATASSAISPSMSSAMSPTL 892
Cdd:PHA03247 2704 PPPTPEpaphaLVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATP-GGPARPARPPTTAGPPAPAPPAAPAAGPPRR 2782

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  893 DPPPSVTSQRREEEK----WEAQSEGHPFITSRSSSPLQLNLLQEEMPRPSESPDQMRRNTCPQTEYCVTGnngseSSPA 968
Cdd:PHA03247 2783 LTRPAVASLSESRESlpspWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLG-----GSVA 2857

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 577861068  969 TTGALSTGSPPRENPSHPTASAlstgSPPMKNPSHP--TASTLSMGLPPS-----RTPSHPTATVLSTGSPPSESPS 1038
Cdd:PHA03247 2858 PGGDVRRRPPSRSPAAKPAAPA----RPPVRRLARPavSRSTESFALPPDqperpPQPQAPPPPQPQPQPPPPPQPQ 2930
PHA03247 PHA03247
large tegument protein UL36; Provisional
 748-1038 8.57e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 8.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  748 PPDSSSSNTGSGPRRGAHQNAQPccpsAASSPHTSSPTFPPAAmvPSQAPYLVPAFPLPAATSPGREYAAPGTAPEGLHG 827
Cdd:PHA03247 2592 PPQSARPRAPVDDRGDPRGPAPP----SPLPPDTHAPDPPPPS--PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPR 2665

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  828 LPLSEGLQPYPAFPF---------PYLDTFMTVFLPDPPVCPLLSPSFLPCPFLGATASSAISPSMSSAMSPTLDPPPSV 898
Cdd:PHA03247 2666 RARRLGRAAQASSPPqrprrraarPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVP 2745

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  899 TSQRREEEKWEAQSEGHPFITSRSSSP-LQLNLLQEEMPRPSESPDQMRRNTCPQTEycvTGNNGSESSPATTGALSTGS 977
Cdd:PHA03247 2746 AGPATPGGPARPARPPTTAGPPAPAPPaAPAAGPPRRLTRPAVASLSESRESLPSPW---DPADPPAAVLAPAAALPPAA 2822

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 577861068  978 PPrENPSHPTASALSTGSPPmknPSHPTASTLSMG-----------LPPSR-------TPSHPTATVLSTGSPPSESPS 1038
Cdd:PHA03247 2823 SP-AGPLPPPTSAQPTAPPP---PPGPPPPSLPLGgsvapggdvrrRPPSRspaakpaAPARPPVRRLARPAVSRSTES 2897
PHA03247 PHA03247
large tegument protein UL36; Provisional
 696-1039 2.09e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  696 REKILSSPYSSYLQQESRSKAKYSYFQGDSTSKQTRSAGCRKGKHKRKKLPEPPDSSSSntgSGPRRGAHQNAQPCCPSA 775
Cdd:PHA03247 2649 PERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPT---PEPAPHALVSATPLPPGP 2725

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  776 ASSPHTSSPtfPPAAMVPSQAPY--LVPAFPLPAATSPGREYAAPGTAPEGLHGLPLSEGLQPYPAFPFPYLDTFMTVFL 853
Cdd:PHA03247 2726 AAARQASPA--LPAAPAPPAVPAgpATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  854 PDPPVCPLLSP-SFLPCPFLGATASSAISPSMSSAMSPTLDPPPSVTS-----------QRReeekweAQSEGHPFITSR 921
Cdd:PHA03247 2804 PADPPAAVLAPaAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPlggsvapggdvRRR------PPSRSPAAKPAA 2877

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  922 SSSPLQLNLLQEEMPRPSES----PDQMRRNTCPQTEYCVTGNNGSESSPATTGALSTgsPPR-ENPSHPTASALSTGSP 996
Cdd:PHA03247 2878 PARPPVRRLARPAVSRSTESfalpPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPP--PPRpQPPLAPTTDPAGAGEP 2955

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 577861068  997 PMKNPSHPTASTLSMGLPPSRTPSHPTATVLSTGSPPSESPSR 1039
Cdd:PHA03247 2956 SGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTG 2998
KinA COG5805
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ...
 274-374 3.17e-03

Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 444507 [Multi-domain]  Cd Length: 496  Bit Score: 41.64  E-value: 3.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  274 IFTTTHTPGcVFLEVDEKAVPLLGYLPQDLIGTSILSYLHPEDRSLMVAIHQKVLKYAGHPPFEHSPIrfcTQNGDYIIL 353
Cdd:COG5805   169 LICVIDTDG-RILFINESIERLFGAPREELIGKNLLELLHPCDKEEFKERIESITEVWQEFIIEREII---TKDGRIRYF 244

                          90       100
                  ....*....|....*....|..
gi 577861068  354 DSSWSSFVNP-WSRKISFIIGR 374
Cdd:COG5805   245 EAVIVPLIDTdGSVKGILVILR 266
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
752-1014 4.53e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.01  E-value: 4.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  752 SSSNTGSGPRRGAHQN-AQPCCPSAASSPHTSSPTFPPA--AMVPSQAPYLVPAFPLPAATSPGREYAAPGTAPEGLHGL 828
Cdd:PRK12323  366 GQSGGGAGPATAAAAPvAQPAPAAAAPAAAAPAPAAPPAapAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPG 445

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  829 PLSEGLQPYPAFPFPyldtfmtvfLPDPPVCPLLSPSFLpcpflgATASSAISPSMSSAMSPTLDPPPsvtsqrreeekW 908
Cdd:PRK12323  446 GAPAPAPAPAAAPAA---------AARPAAAGPRPVAAA------AAAAPARAAPAAAPAPADDDPPP-----------W 499

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 577861068  909 EAQSEGHPFITSRSSSPLQLNLLQEEMPRPSESPDQMRRNTCPQteycvtgnngsESSPATTGALSTGSPPRENPSHPTA 988
Cdd:PRK12323  500 EELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAP-----------APAAAPAPRAAAATEPVVAPRPPRA 568

                         250       260
                  ....*....|....*....|....*.
gi 577861068  989 SAlsTGSPPMKNPSHPtasTLSMGLP 1014
Cdd:PRK12323  569 SA--SGLPDMFDGDWP---ALAARLP 589
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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