receptor tyrosine-protein kinase erbB-2 isoform e [Homo sapiens]
epidermal growth factor receptor; receptor tyrosine-protein kinase erbB-4( domain architecture ID 12013602)
epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that catalyzes the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates, and is activated by ligand (EGF family)-induced dimerization; receptor tyrosine-protein kinase erbB-4 catalyzes the transfer of the gamma-phosphoryl group from ATP to tyrosine residues in protein substrates; it plays an essential role as cell surface receptor for neuregulins and EGF family proteins
List of domain hits
Name | Accession | Description | Interval | E-value | |||
GF_recep_IV | pfam14843 | Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
481-603 | 6.00e-51 | |||
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030). : Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 171.79 E-value: 6.00e-51
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Furin-like | pfam00757 | Furin-like cysteine rich region; |
159-308 | 7.65e-35 | |||
Furin-like cysteine rich region; : Pssm-ID: 395614 [Multi-domain] Cd Length: 143 Bit Score: 128.71 E-value: 7.65e-35
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Recep_L_domain | pfam01030 | Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ... |
22-143 | 1.65e-32 | |||
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain. : Pssm-ID: 460032 Cd Length: 112 Bit Score: 120.80 E-value: 1.65e-32
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Recep_L_domain | pfam01030 | Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ... |
336-452 | 8.85e-21 | |||
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain. : Pssm-ID: 460032 Cd Length: 112 Bit Score: 87.67 E-value: 8.85e-21
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Name | Accession | Description | Interval | E-value | |||
GF_recep_IV | pfam14843 | Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
481-603 | 6.00e-51 | |||
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030). Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 171.79 E-value: 6.00e-51
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Furin-like | pfam00757 | Furin-like cysteine rich region; |
159-308 | 7.65e-35 | |||
Furin-like cysteine rich region; Pssm-ID: 395614 [Multi-domain] Cd Length: 143 Bit Score: 128.71 E-value: 7.65e-35
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Recep_L_domain | pfam01030 | Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ... |
22-143 | 1.65e-32 | |||
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain. Pssm-ID: 460032 Cd Length: 112 Bit Score: 120.80 E-value: 1.65e-32
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Recep_L_domain | pfam01030 | Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ... |
336-452 | 8.85e-21 | |||
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain. Pssm-ID: 460032 Cd Length: 112 Bit Score: 87.67 E-value: 8.85e-21
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FU | smart00261 | Furin-like repeats; |
527-573 | 8.04e-06 | |||
Furin-like repeats; Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 43.27 E-value: 8.04e-06
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FU | cd00064 | Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
205-250 | 1.08e-04 | |||
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors. Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 40.19 E-value: 1.08e-04
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FU | cd00064 | Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
532-577 | 2.61e-04 | |||
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors. Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 39.04 E-value: 2.61e-04
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FU | smart00261 | Furin-like repeats; |
205-240 | 3.00e-03 | |||
Furin-like repeats; Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 35.95 E-value: 3.00e-03
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Name | Accession | Description | Interval | E-value | |||
GF_recep_IV | pfam14843 | Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
481-603 | 6.00e-51 | |||
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030). Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 171.79 E-value: 6.00e-51
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Furin-like | pfam00757 | Furin-like cysteine rich region; |
159-308 | 7.65e-35 | |||
Furin-like cysteine rich region; Pssm-ID: 395614 [Multi-domain] Cd Length: 143 Bit Score: 128.71 E-value: 7.65e-35
|
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Recep_L_domain | pfam01030 | Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ... |
22-143 | 1.65e-32 | |||
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain. Pssm-ID: 460032 Cd Length: 112 Bit Score: 120.80 E-value: 1.65e-32
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Recep_L_domain | pfam01030 | Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. ... |
336-452 | 8.85e-21 | |||
Receptor L domain; The L domains from these receptors make up the bilobal ligand binding site. Each L domain consists of a single-stranded right hand beta-helix. This Pfam entry is missing the first 50 amino acid residues of the domain. Pssm-ID: 460032 Cd Length: 112 Bit Score: 87.67 E-value: 8.85e-21
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Furin-like | pfam00757 | Furin-like cysteine rich region; |
472-573 | 2.96e-06 | |||
Furin-like cysteine rich region; Pssm-ID: 395614 [Multi-domain] Cd Length: 143 Bit Score: 47.05 E-value: 2.96e-06
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FU | smart00261 | Furin-like repeats; |
527-573 | 8.04e-06 | |||
Furin-like repeats; Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 43.27 E-value: 8.04e-06
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FU | cd00064 | Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
205-250 | 1.08e-04 | |||
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors. Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 40.19 E-value: 1.08e-04
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FU | cd00064 | Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
532-577 | 2.61e-04 | |||
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors. Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 39.04 E-value: 2.61e-04
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GF_recep_IV | pfam14843 | Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine ... |
164-240 | 8.29e-04 | |||
Growth factor receptor domain IV; This is the fourth extracellular domain of receptor tyrosine protein kinases. Interaction between this domain and the furin-like domain (pfam00757) regulates the binding of ligands to the receptor L domains (pfam01030). Pssm-ID: 464344 [Multi-domain] Cd Length: 132 Bit Score: 39.66 E-value: 8.29e-04
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FU | cd00064 | Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ... |
480-514 | 1.25e-03 | |||
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors. Pssm-ID: 238021 [Multi-domain] Cd Length: 49 Bit Score: 37.11 E-value: 1.25e-03
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FU | smart00261 | Furin-like repeats; |
479-514 | 1.34e-03 | |||
Furin-like repeats; Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 36.72 E-value: 1.34e-03
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FU | smart00261 | Furin-like repeats; |
205-240 | 3.00e-03 | |||
Furin-like repeats; Pssm-ID: 214589 [Multi-domain] Cd Length: 45 Bit Score: 35.95 E-value: 3.00e-03
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Blast search parameters | ||||
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