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Conserved domains on  [gi|594140540|ref|NP_001277247|]
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zinc finger protein 304 isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 8.51e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.90  E-value: 8.51e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 594140540   13 CVTFEDVFVYFSREEWELLEEAQRFLYRDVMLENFALVATL 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
325-680 4.65e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.12  E-value: 4.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 325 SHVCKECGKAFIHLHHLKMHQKFHTGKRHYTCS--ECGKAFSRKDTLVQHQRVHTGERSYDCS----------------E 386
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskasssslsS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 387 CGKAYSRSSHLVQH---------------QRIHTGERPYK-CNKCGKAF-------------------SRKDTLVQHQRF 431
Cdd:COG5048  113 SSSNSNDNNLLSSHslppssrdpqlpdllSISNLRNNPLPgNNSSSVNTpqsnslhpplpanslskdpSSNLSLLISSNV 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 432 HTGERPYECSECGKFFSQSSHLIEHWRIHTGARPYECIECGKFFSHNSSLIKHRRVHTGARSYVCSKCGKAFGCKDTLVQ 511
Cdd:COG5048  193 STSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 512 HQIIHTGAR-------PYECSECGKAFSRKDTLVQHQ--KIHTGE--RPYECGE--CGKFFSHSSNLIVHQRIHTGAKPY 578
Cdd:COG5048  273 SSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPA 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 579 ECNECGKCFSHNSSLI--LHQRVH-----TGARPYVCSE-CGKAYISSSHLVQ-HKKVHTGARPYEC--SECGKFFSRNS 647
Cdd:COG5048  353 KEKLLNSSSKFSPLLNnePPQSLQqykdlKNDKKSETLSnSCIRNFKRDSNLSlHIITHLSFRPYNCknPPCSKSFNRHY 432

                        410       420       430
                 ....*....|....*....|....*....|...
gi 594140540 648 GLILHQRVHTgEKPYVCSECGKAYSRSSHLVRH 680
Cdd:COG5048  433 NLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 8.51e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.90  E-value: 8.51e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 594140540   13 CVTFEDVFVYFSREEWELLEEAQRFLYRDVMLENFALVATL 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
14-73 2.07e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.56  E-value: 2.07e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 594140540    14 VTFEDVFVYFSREEWELLEEAQRFLYRDVMLENFALVATLAFIFPVP-CSCAVGGGRKPWV 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPdLISQLEQGEEPWI 61
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-53 1.12e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.74  E-value: 1.12e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 594140540  14 VTFEDVFVYFSREEWELLEEAQRFLYRDVMLENFALVATL 53
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
325-680 4.65e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.12  E-value: 4.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 325 SHVCKECGKAFIHLHHLKMHQKFHTGKRHYTCS--ECGKAFSRKDTLVQHQRVHTGERSYDCS----------------E 386
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskasssslsS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 387 CGKAYSRSSHLVQH---------------QRIHTGERPYK-CNKCGKAF-------------------SRKDTLVQHQRF 431
Cdd:COG5048  113 SSSNSNDNNLLSSHslppssrdpqlpdllSISNLRNNPLPgNNSSSVNTpqsnslhpplpanslskdpSSNLSLLISSNV 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 432 HTGERPYECSECGKFFSQSSHLIEHWRIHTGARPYECIECGKFFSHNSSLIKHRRVHTGARSYVCSKCGKAFGCKDTLVQ 511
Cdd:COG5048  193 STSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 512 HQIIHTGAR-------PYECSECGKAFSRKDTLVQHQ--KIHTGE--RPYECGE--CGKFFSHSSNLIVHQRIHTGAKPY 578
Cdd:COG5048  273 SSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPA 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 579 ECNECGKCFSHNSSLI--LHQRVH-----TGARPYVCSE-CGKAYISSSHLVQ-HKKVHTGARPYEC--SECGKFFSRNS 647
Cdd:COG5048  353 KEKLLNSSSKFSPLLNnePPQSLQqykdlKNDKKSETLSnSCIRNFKRDSNLSlHIITHLSFRPYNCknPPCSKSFNRHY 432

                        410       420       430
                 ....*....|....*....|....*....|...
gi 594140540 648 GLILHQRVHTgEKPYVCSECGKAYSRSSHLVRH 680
Cdd:COG5048  433 NLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
396-421 2.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.27e-04
                          10        20
                  ....*....|....*....|....*.
gi 594140540  396 HLVQHQRIHTGERPYKCNKCGKAFSR 421
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 8.51e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.90  E-value: 8.51e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 594140540   13 CVTFEDVFVYFSREEWELLEEAQRFLYRDVMLENFALVATL 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB smart00349
krueppel associated box;
14-73 2.07e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.56  E-value: 2.07e-18
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 594140540    14 VTFEDVFVYFSREEWELLEEAQRFLYRDVMLENFALVATLAFIFPVP-CSCAVGGGRKPWV 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPdLISQLEQGEEPWI 61
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-53 1.12e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.74  E-value: 1.12e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 594140540  14 VTFEDVFVYFSREEWELLEEAQRFLYRDVMLENFALVATL 53
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
325-680 4.65e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 75.12  E-value: 4.65e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 325 SHVCKECGKAFIHLHHLKMHQKFHTGKRHYTCS--ECGKAFSRKDTLVQHQRVHTGERSYDCS----------------E 386
Cdd:COG5048   33 PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskasssslsS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 387 CGKAYSRSSHLVQH---------------QRIHTGERPYK-CNKCGKAF-------------------SRKDTLVQHQRF 431
Cdd:COG5048  113 SSSNSNDNNLLSSHslppssrdpqlpdllSISNLRNNPLPgNNSSSVNTpqsnslhpplpanslskdpSSNLSLLISSNV 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 432 HTGERPYECSECGKFFSQSSHLIEHWRIHTGARPYECIECGKFFSHNSSLIKHRRVHTGARSYVCSKCGKAFGCKDTLVQ 511
Cdd:COG5048  193 STSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQS 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 512 HQIIHTGAR-------PYECSECGKAFSRKDTLVQHQ--KIHTGE--RPYECGE--CGKFFSHSSNLIVHQRIHTGAKPY 578
Cdd:COG5048  273 SSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPA 352

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 579 ECNECGKCFSHNSSLI--LHQRVH-----TGARPYVCSE-CGKAYISSSHLVQ-HKKVHTGARPYEC--SECGKFFSRNS 647
Cdd:COG5048  353 KEKLLNSSSKFSPLLNnePPQSLQqykdlKNDKKSETLSnSCIRNFKRDSNLSlHIITHLSFRPYNCknPPCSKSFNRHY 432

                        410       420       430
                 ....*....|....*....|....*....|...
gi 594140540 648 GLILHQRVHTgEKPYVCSECGKAYSRSSHLVRH 680
Cdd:COG5048  433 NLIPHKKIHT-NHAPLLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
133-568 3.28e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 3.28e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 133 QKAHPCEMCDPLLKdilHLAEHQGSHLTQKL--CTRGLCRRRFSFSANFYQHQKQHNGENCFRGDDGGASFVKSCTVHML 210
Cdd:COG5048   34 DSCPNCTDSFSRLE---HLTRHIRSHTGEKPsqCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 211 grsFTCREEGMDLPDSSGLFQHQTTYNRvspcrrtecMESFPHSSSLRQHQGDYDGqmlFSCGDEGKAFLDTFTLLDSQM 290
Cdd:COG5048  111 ---SSSSSNSNDNNLLSSHSLPPSSRDP---------QLPDLLSISNLRNNPLPGN---NSSSVNTPQSNSLHPPLPANS 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 291 ThaevrpfrclpCGNVFKEKSALINHRKIHSGEISHVCKECGKaFIHLHHLKMHQKFHTGKRHYTCSECGKAFSRKDTLV 370
Cdd:COG5048  176 L-----------SKDPSSNLSLLISSNVSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQ 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 371 QHQRVHTGERSYDCSECGKAYSRSSHLVQHQRIHTGER-------PYKCNKCGKAFSRKDTLVQHQR--FHTGE--RPYE 439
Cdd:COG5048  244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFS 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 440 CSE--CGKFFSQSSHLIEHWRIHTGARPYECIECGKFFSHNSSLIKHRRVHTGARSYVC---SKCGKAFGCKDTLVQ--- 511
Cdd:COG5048  324 CPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDLKndkKSETLSNSCIRNFKRdsn 403

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 594140540 512 ---HQIIHTGARPYEC--SECGKAFSRKDTLVQHQKIHTGERPYECgeCGKFFSHSSNLIVH 568
Cdd:COG5048  404 lslHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSN 463
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
380-698 2.72e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.72  E-value: 2.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 380 RSYDCSECGKAYSRSSHLVQHQRIHTGERPYKCNK--CGKAFSRKDTLVQHQRFHTGERPYECS-ECGKFFSQSSHLIEH 456
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 457 WRIHTGARPYECIECGKFFSHNSSLIKHRRVHTGARSYVCSKCGKAF----GCKDTLVQHQIIHTGARPYECSecgkafs 532
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpQSNSLHPPLPANSLSKDPSSNL------- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 533 rkDTLVQHQKIHTGERPYECGEcGKFFSHSSNLIVHQRIHTGAKPYECNECGKCFSHNSSLILHQRVHTGARPYVCSECG 612
Cdd:COG5048  185 --SLLISSNVSTSIPSSSENSP-LSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 613 KAYISSSHLVQHKKVHTGAR-------PYECSECGKFFSRNSGLILHQR--VHTGE--KPYVCSE--CGKAYSRSSHLVR 679
Cdd:COG5048  262 RSSLPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                        330
                 ....*....|....*....
gi 594140540 680 HQKAHTGERAHECNSFGGP 698
Cdd:COG5048  342 HILLHTSISPAKEKLLNSS 360
zf-H2C2_2 pfam13465
Zinc-finger double domain;
396-421 2.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.27e-04
                          10        20
                  ....*....|....*....|....*.
gi 594140540  396 HLVQHQRIHTGERPYKCNKCGKAFSR 421
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 575-685 4.94e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 4.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594140540 575 AKPYECNECGKCFSHNSSLIL----HQRVHTGARPYVCS--ECGKAYISSSHLVQHKKvHtgarpyecSECGKFFSRNSG 648
Cdd:COG5189  315 KLPCTNSSSNGKLAHGGERNIdtpsRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHML-H--------GHQNQKLHENPS 385

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 594140540 649 LILHQRVHTGEKPYVCSECGKAYSRSSHLVRHQKAHT 685
Cdd:COG5189  386 PEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
425-449 1.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.80e-03
                          10        20
                  ....*....|....*....|....*
gi 594140540  425 LVQHQRFHTGERPYECSECGKFFSQ 449
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-365 2.78e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.78e-03
                          10        20
                  ....*....|....*....|....*.
gi 594140540  340 HLKMHQKFHTGKRHYTCSECGKAFSR 365
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 578-600 3.75e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.75e-03
                          10        20
                  ....*....|....*....|...
gi 594140540  578 YECNECGKCFSHNSSLILHQRVH 600
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
537-561 4.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.16e-03
                          10        20
                  ....*....|....*....|....*
gi 594140540  537 LVQHQKIHTGERPYECGECGKFFSH 561
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
564-589 4.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.63e-03
                          10        20
                  ....*....|....*....|....*.
gi 594140540  564 NLIVHQRIHTGAKPYECNECGKCFSH 589
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 550-572 6.44e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.44e-03
                          10        20
                  ....*....|....*....|...
gi 594140540  550 YECGECGKFFSHSSNLIVHQRIH 572
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 354-376 9.35e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 9.35e-03
                          10        20
                  ....*....|....*....|...
gi 594140540  354 YTCSECGKAFSRKDTLVQHQRVH 376
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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