NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|595582098|ref|NP_001277701|]
View 

trophinin isoform 5 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 596-756 1.07e-23

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


:

Pssm-ID: 426270  Cd Length: 205  Bit Score: 99.65  E-value: 1.07e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  596 LVKYLLVKDQTKIPIKRSDMLKDVIQEYE-DYFPEIIERASYALEKMFRVNLKEID--------------------KQNN 654
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENRkRLFKKVFEEAQKILRDVFGMELVELPakeekkttvtsqqrraaaksSRSK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  655 LYILIST---QESSAGIMGTTK---------DTPKLGLLMVILSVIFMNGNKASEAVIWEVLRKLGLH---PGVKHSLFG 719
Cdd:pfam01454  81 SYILVSTlppEYRVPAIIWPSKapsfvldqdEATYTGILTVILSLILLSGGSISEQELLRYLRRLGIDtdgTKEIPPLNG 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 595582098  720 EVKKLItDEFVKQKYLEYKRVPNSRP--PEYEFFWGLRS 756
Cdd:pfam01454 161 NTDDLL-KRLVKQGYLVRTKEGASDDgeEIIEYRVGPRA 198
MSCRAMM_ClfA super family cl41352
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 272-490 9.83e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


The actual alignment was detected with superfamily member NF033609:

Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 49.14  E-value: 9.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 272 SNRQIEASSRQ-TEASNRQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGASNRQIEASNRQIGASNRQTEVSS 350
Cdd:NF033609  33 SSKEADASENSvTQSDSASNESKSNDSSSVSAAPKTDDTNVSDTKTSSNTNNGETSVAQNPAQQETTQSASTNATTEETP 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 351 RQIEASNRQIGASNRQTEASNRQIGASNRQTEASNRQIGASNRQTDASNRQTDASNRQTEASSR--QTEASSRQTEASSR 428
Cdd:NF033609 113 VTGEATTTATNQANTPATTQSSNTNAEELVNQTSNETTSNDTNTVSSVNSPQNSTNAENVSTTQdtSTEATPSNNESAPQ 192

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 595582098 429 QTEASSRQIeaSAAAVRPKKPRgkkgnNKGSNSASEPSEAPPAIQTVTNHALSVTVRIRRGS 490
Cdd:NF033609 193 STDASNKDV--VNQAVNTSAPR-----MRAFSLAAVAADAPAAGTDITNQLTNVTVGIDSGT 247
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 20-243 4.74e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 43.75  E-value: 4.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098   20 PAGSLGLPFSPDVQSETT---EKDPPIASRSKKNKNKKNSIKPMDKTTPAPPPVPSANDNASNKPKVTLQALNLPMFTQI 96
Cdd:pfam05109 442 PNTTTGLPSSTHVPTNLTapaSTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNAT 521

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098   97 SQASA-TTEAPNIQASVTSQTQKAKTMrVTPKVSLTGSEDATTQLKPPLQALNLPVTTPT--IQTPVANESANSLASTav 173
Cdd:pfam05109 522 SPTPAvTTPTPNATSPTLGKTSPTSAV-TTPTPNATSPTPAVTTPTPNATIPTLGKTSPTsaVTTPTPNATSPTVGET-- 598

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  174 nkSKKASTANNAANKTVPSAAEISLASAATHTVTTqGQAAKETGSIQTIAATARSKKNSKGKRTPAKTTN 243
Cdd:pfam05109 599 --SPQANTTNHTLGGTSSTPVVTSPPKNATSAVTT-GQHNITSSSTSSMSLRPSSISETLSPSTSDNSTS 665
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 596-756 1.07e-23

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 99.65  E-value: 1.07e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  596 LVKYLLVKDQTKIPIKRSDMLKDVIQEYE-DYFPEIIERASYALEKMFRVNLKEID--------------------KQNN 654
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENRkRLFKKVFEEAQKILRDVFGMELVELPakeekkttvtsqqrraaaksSRSK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  655 LYILIST---QESSAGIMGTTK---------DTPKLGLLMVILSVIFMNGNKASEAVIWEVLRKLGLH---PGVKHSLFG 719
Cdd:pfam01454  81 SYILVSTlppEYRVPAIIWPSKapsfvldqdEATYTGILTVILSLILLSGGSISEQELLRYLRRLGIDtdgTKEIPPLNG 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 595582098  720 EVKKLItDEFVKQKYLEYKRVPNSRP--PEYEFFWGLRS 756
Cdd:pfam01454 161 NTDDLL-KRLVKQGYLVRTKEGASDDgeEIIEYRVGPRA 198
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 272-490 9.83e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 49.14  E-value: 9.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 272 SNRQIEASSRQ-TEASNRQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGASNRQIEASNRQIGASNRQTEVSS 350
Cdd:NF033609  33 SSKEADASENSvTQSDSASNESKSNDSSSVSAAPKTDDTNVSDTKTSSNTNNGETSVAQNPAQQETTQSASTNATTEETP 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 351 RQIEASNRQIGASNRQTEASNRQIGASNRQTEASNRQIGASNRQTDASNRQTDASNRQTEASSR--QTEASSRQTEASSR 428
Cdd:NF033609 113 VTGEATTTATNQANTPATTQSSNTNAEELVNQTSNETTSNDTNTVSSVNSPQNSTNAENVSTTQdtSTEATPSNNESAPQ 192

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 595582098 429 QTEASSRQIeaSAAAVRPKKPRgkkgnNKGSNSASEPSEAPPAIQTVTNHALSVTVRIRRGS 490
Cdd:NF033609 193 STDASNKDV--VNQAVNTSAPR-----MRAFSLAAVAADAPAAGTDITNQLTNVTVGIDSGT 247
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 264-442 1.67e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.84  E-value: 1.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 264 ASGRQTEASNRQIEASSRQTEASNRQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGASNRQIEASNRQIGASN 343
Cdd:COG4942   17 AQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 344 RQTEvssRQIEASNRQIGASNRQTEASNRQIGASNRQTEASNRQIGASNRQTDASNRQTDA-SNRQTEASSRQTEASSRQ 422
Cdd:COG4942   97 AELE---AQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEElRADLAELAALRAELEAER 173

                        170       180
                 ....*....|....*....|
gi 595582098 423 TEASSRQTEASSRQIEASAA 442
Cdd:COG4942  174 AELEALLAELEEERAALEAL 193
PTZ00121 PTZ00121
MAEBL; Provisional
 267-524 5.35e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.06  E-value: 5.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  267 RQTEASNRQIEAssRQTEASNRQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGASNRQIE---------ASNR 337
Cdd:PTZ00121 1212 RKAEEARKAEDA--KKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEarkadelkkAEEK 1289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  338 QIGASNRQTEVSSRQIEASN-----RQIGASNRQTEASNRQIGASNRQTEASNRQIGASNRQTDASNRQTDASNRQTEAS 412
Cdd:PTZ00121 1290 KKADEAKKAEEKKKADEAKKkaeeaKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAA 1369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  413 SRQTEASSRQTEASSRQTEASSRQIEASAAAVRPKKP----RGKKGNNKGSNSASEPSEAPPAIQTVTNHALSVtvriRR 488
Cdd:PTZ00121 1370 EKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKadelKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEA----KK 1445

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 595582098  489 GSRARKAANKNRATESQAQIAEQGAQASEASISALE 524
Cdd:PTZ00121 1446 ADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEE 1481
MscS_porin pfam12795
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ...
 270-445 1.23e-04

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.


Pssm-ID: 432790 [Multi-domain]  Cd Length: 238  Bit Score: 44.21  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  270 EASNRQIEASSRQTEASN-RQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGASNRQIEASNRQIGASNRQTEV 348
Cdd:pfam12795   4 ELEKAKLDEAAKKKLLQDlQQALSLLDKIDASKQRAAAYQKALDDAPAELRELRQELAALQAKAEAAPKEILASLSLEEL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  349 SSRQIEASNRQIGASNRQTEASNRQIGASNRQTEASNRQIGASNRQTDASNRQTDASNRQTEASsrQTEASSRQTEASSR 428
Cdd:pfam12795  84 EQRLLQTSAQLQELQNQLAQLNSQLIELQTRPERAQQQLSEARQRLQQIRNRLNGPAPPGEPLS--EAQRWALQAELAAL 161

                         170
                  ....*....|....*..
gi 595582098  429 QTEASSRQIEASAAAVR 445
Cdd:pfam12795 162 KAQIDMLEQELLSNNNR 178
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 20-243 4.74e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 43.75  E-value: 4.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098   20 PAGSLGLPFSPDVQSETT---EKDPPIASRSKKNKNKKNSIKPMDKTTPAPPPVPSANDNASNKPKVTLQALNLPMFTQI 96
Cdd:pfam05109 442 PNTTTGLPSSTHVPTNLTapaSTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNAT 521

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098   97 SQASA-TTEAPNIQASVTSQTQKAKTMrVTPKVSLTGSEDATTQLKPPLQALNLPVTTPT--IQTPVANESANSLASTav 173
Cdd:pfam05109 522 SPTPAvTTPTPNATSPTLGKTSPTSAV-TTPTPNATSPTPAVTTPTPNATIPTLGKTSPTsaVTTPTPNATSPTVGET-- 598

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  174 nkSKKASTANNAANKTVPSAAEISLASAATHTVTTqGQAAKETGSIQTIAATARSKKNSKGKRTPAKTTN 243
Cdd:pfam05109 599 --SPQANTTNHTLGGTSSTPVVTSPPKNATSAVTT-GQHNITSSSTSSMSLRPSSISETLSPSTSDNSTS 665
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 199-412 7.37e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 43.36  E-value: 7.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 199 ASAATHTVTTQGQAAKETGSIQTIAATARSKKNSKGKRTPAKTTNTDN-EYVEASNAIEASSRQIGASGRQTEASNRQIE 277
Cdd:NF033609  37 ADASENSVTQSDSASNESKSNDSSSVSAAPKTDDTNVSDTKTSSNTNNgETSVAQNPAQQETTQSASTNATTEETPVTGE 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 278 ASSRQTEASNRQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGASNRQIEASnrqigasnrqTEVSSRQIEASN 357
Cdd:NF033609 117 ATTTATNQANTPATTQSSNTNAEELVNQTSNETTSNDTNTVSSVNSPQNSTNAENVST----------TQDTSTEATPSN 186

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 595582098 358 RQigASNRQTEASNRQIGASNRQTEASN-RQIGASNRQTDASNRQTDASNRQTEAS 412
Cdd:NF033609 187 NE--SAPQSTDASNKDVVNQAVNTSAPRmRAFSLAAVAADAPAAGTDITNQLTNVT 240
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 249-525 6.52e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.04  E-value: 6.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098   249 VEASNAIEASSRQIGASGRQTEASNRQIEASSRQTEASNRQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGAS 328
Cdd:TIGR02168  666 AKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL 745

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098   329 NRQIEASNRQIGASNRQTEVSSRQIEASNRQIGASNRQTEASNRQIGASNRQTEASNRQIGASNRQTDASNRqtdasnRQ 408
Cdd:TIGR02168  746 EERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNE------EA 819

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098   409 TEASSRQtEASSRQTEASSRQTEASSRQIEASAAAVrpkkprgkKGNNKGSNSASEP-SEAPPAIQTVTNHALSVTVRIR 487
Cdd:TIGR02168  820 ANLRERL-ESLERRIAATERRLEDLEEQIEELSEDI--------ESLAAEIEELEELiEELESELEALLNERASLEEALA 890

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 595582098   488 RG-SRARKAANKNRATESQAQIAEQGAQASEASISALET 525
Cdd:TIGR02168  891 LLrSELEELSEELRELESKRSELRRELEELREKLAQLEL 929
PHA03255 PHA03255
BDLF3; Provisional
 157-304 9.64e-03

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 38.73  E-value: 9.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 157 QTPVANESANSLASTAVNKSKKASTANNAANKTVPSAAEISLASAATHTVTTQGQAAKETGSIQTIAATARSKKNSKGKR 236
Cdd:PHA03255  19 ETSLIWTSSGSSTASAGNVTGTTAVTTPSPSASGPSTNQSTTLTTTSAPITTTAILSTNTTTVTSTGTTVTPVPTTSNAS 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 595582098 237 TPAKTTNTDNEYVEASNAieASSRQIGASGRQTEASNRQIEASSRQTEASNRQTEASSRQTEASSRQT 304
Cdd:PHA03255  99 TINVTTKVTAQNITATEA--GTGTSTGVTSNVTTRSSSTTSATTRITNATTLAPTLSSKGTSNATKTT 164
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 596-756 1.07e-23

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 99.65  E-value: 1.07e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  596 LVKYLLVKDQTKIPIKRSDMLKDVIQEYE-DYFPEIIERASYALEKMFRVNLKEID--------------------KQNN 654
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENRkRLFKKVFEEAQKILRDVFGMELVELPakeekkttvtsqqrraaaksSRSK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  655 LYILIST---QESSAGIMGTTK---------DTPKLGLLMVILSVIFMNGNKASEAVIWEVLRKLGLH---PGVKHSLFG 719
Cdd:pfam01454  81 SYILVSTlppEYRVPAIIWPSKapsfvldqdEATYTGILTVILSLILLSGGSISEQELLRYLRRLGIDtdgTKEIPPLNG 160

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 595582098  720 EVKKLItDEFVKQKYLEYKRVPNSRP--PEYEFFWGLRS 756
Cdd:pfam01454 161 NTDDLL-KRLVKQGYLVRTKEGASDDgeEIIEYRVGPRA 198
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 272-490 9.83e-06

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 49.14  E-value: 9.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 272 SNRQIEASSRQ-TEASNRQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGASNRQIEASNRQIGASNRQTEVSS 350
Cdd:NF033609  33 SSKEADASENSvTQSDSASNESKSNDSSSVSAAPKTDDTNVSDTKTSSNTNNGETSVAQNPAQQETTQSASTNATTEETP 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 351 RQIEASNRQIGASNRQTEASNRQIGASNRQTEASNRQIGASNRQTDASNRQTDASNRQTEASSR--QTEASSRQTEASSR 428
Cdd:NF033609 113 VTGEATTTATNQANTPATTQSSNTNAEELVNQTSNETTSNDTNTVSSVNSPQNSTNAENVSTTQdtSTEATPSNNESAPQ 192

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 595582098 429 QTEASSRQIeaSAAAVRPKKPRgkkgnNKGSNSASEPSEAPPAIQTVTNHALSVTVRIRRGS 490
Cdd:NF033609 193 STDASNKDV--VNQAVNTSAPR-----MRAFSLAAVAADAPAAGTDITNQLTNVTVGIDSGT 247
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 264-442 1.67e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.84  E-value: 1.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 264 ASGRQTEASNRQIEASSRQTEASNRQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGASNRQIEASNRQIGASN 343
Cdd:COG4942   17 AQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 344 RQTEvssRQIEASNRQIGASNRQTEASNRQIGASNRQTEASNRQIGASNRQTDASNRQTDA-SNRQTEASSRQTEASSRQ 422
Cdd:COG4942   97 AELE---AQKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEElRADLAELAALRAELEAER 173

                        170       180
                 ....*....|....*....|
gi 595582098 423 TEASSRQTEASSRQIEASAA 442
Cdd:COG4942  174 AELEALLAELEEERAALEAL 193
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 268-524 4.95e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.85  E-value: 4.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 268 QTEASNRQIEASSRQTEASNRQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGASNRQIEAsnrqigASNRQTE 347
Cdd:COG1196  219 KEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEE------AQAEEYE 292

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 348 VSSRQIEASNRQIGASNRQTEASNRQIGASNRQTEASNRQIGASNRQTDASNRQTDASNRQTEASSRQTEASSRQTEASS 427
Cdd:COG1196  293 LLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEA 372

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 428 RQTEASSRQIEASAAAVRPKKprgkkgnnkgsnsasepsEAPPAIQTVTNHALSVTVRIRRGSRARKAANKNRATESQAQ 507
Cdd:COG1196  373 ELAEAEEELEELAEELLEALR------------------AAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELE 434

                        250
                 ....*....|....*..
gi 595582098 508 IAEQGAQASEASISALE 524
Cdd:COG1196  435 EEEEEEEEALEEAAEEE 451
PTZ00121 PTZ00121
MAEBL; Provisional
 267-524 5.35e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.06  E-value: 5.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  267 RQTEASNRQIEAssRQTEASNRQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGASNRQIE---------ASNR 337
Cdd:PTZ00121 1212 RKAEEARKAEDA--KKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEarkadelkkAEEK 1289

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  338 QIGASNRQTEVSSRQIEASN-----RQIGASNRQTEASNRQIGASNRQTEASNRQIGASNRQTDASNRQTDASNRQTEAS 412
Cdd:PTZ00121 1290 KKADEAKKAEEKKKADEAKKkaeeaKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAA 1369

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  413 SRQTEASSRQTEASSRQTEASSRQIEASAAAVRPKKP----RGKKGNNKGSNSASEPSEAPPAIQTVTNHALSVtvriRR 488
Cdd:PTZ00121 1370 EKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKadelKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEA----KK 1445

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 595582098  489 GSRARKAANKNRATESQAQIAEQGAQASEASISALE 524
Cdd:PTZ00121 1446 ADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEE 1481
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 251-459 6.09e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.30  E-value: 6.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 251 ASNAIEASSRQIGASGRQTEASNRQIEASSRQTEASNRQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGASNR 330
Cdd:COG4942   18 QADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 331 QIEASNRQIGASNRQTEVSSRQ-------------------------IEASNRQIGASNRQTE---ASNRQIGASNRQTE 382
Cdd:COG4942   98 ELEAQKEELAELLRALYRLGRQpplalllspedfldavrrlqylkylAPARREQAEELRADLAelaALRAELEAERAELE 177

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 595582098 383 ASNRQIGASNRQTDASNRQTDASNRQTEASSRQTEASSRQTEASSRQTEASSRQIEASAAAVRPKKPRGKKGNNKGS 459
Cdd:COG4942  178 ALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAALKGK 254
MscS_porin pfam12795
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ...
 270-445 1.23e-04

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.


Pssm-ID: 432790 [Multi-domain]  Cd Length: 238  Bit Score: 44.21  E-value: 1.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  270 EASNRQIEASSRQTEASN-RQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGASNRQIEASNRQIGASNRQTEV 348
Cdd:pfam12795   4 ELEKAKLDEAAKKKLLQDlQQALSLLDKIDASKQRAAAYQKALDDAPAELRELRQELAALQAKAEAAPKEILASLSLEEL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  349 SSRQIEASNRQIGASNRQTEASNRQIGASNRQTEASNRQIGASNRQTDASNRQTDASNRQTEASsrQTEASSRQTEASSR 428
Cdd:pfam12795  84 EQRLLQTSAQLQELQNQLAQLNSQLIELQTRPERAQQQLSEARQRLQQIRNRLNGPAPPGEPLS--EAQRWALQAELAAL 161

                         170
                  ....*....|....*..
gi 595582098  429 QTEASSRQIEASAAAVR 445
Cdd:pfam12795 162 KAQIDMLEQELLSNNNR 178
PHA00430 PHA00430
tail fiber protein
 325-467 1.48e-04

tail fiber protein


Pssm-ID: 222790 [Multi-domain]  Cd Length: 568  Bit Score: 45.27  E-value: 1.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 325 IGASNR-QIEASNRQI----GASNRQTEVSSRQIEASNRQigASNRQTEASNRQIGAS--NRQTEASNRQIGASNRQTDA 397
Cdd:PHA00430 121 IGVNNDgHLDARGRRIvnlaDAVDDGDAVPLGQIKTWNQS--AWNARNEANRSRNEADraRNQAERFNNESGASATNTKQ 198

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 595582098 398 SNRQTDASNRQTE-----ASSRQTEASSRQTEASSRQTEASSRQIEASAAAVRPKKPRGKKGNNKGSNSASEPSE 467
Cdd:PHA00430 199 WRSEADGSNSEANrfkgyADSMTSSVEAAKGQAESSSKEANTAGDYATKAAASASAAHASEVNAANSATAAATSA 273
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 20-243 4.74e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 43.75  E-value: 4.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098   20 PAGSLGLPFSPDVQSETT---EKDPPIASRSKKNKNKKNSIKPMDKTTPAPPPVPSANDNASNKPKVTLQALNLPMFTQI 96
Cdd:pfam05109 442 PNTTTGLPSSTHVPTNLTapaSTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNAT 521

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098   97 SQASA-TTEAPNIQASVTSQTQKAKTMrVTPKVSLTGSEDATTQLKPPLQALNLPVTTPT--IQTPVANESANSLASTav 173
Cdd:pfam05109 522 SPTPAvTTPTPNATSPTLGKTSPTSAV-TTPTPNATSPTPAVTTPTPNATIPTLGKTSPTsaVTTPTPNATSPTVGET-- 598

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  174 nkSKKASTANNAANKTVPSAAEISLASAATHTVTTqGQAAKETGSIQTIAATARSKKNSKGKRTPAKTTN 243
Cdd:pfam05109 599 --SPQANTTNHTLGGTSSTPVVTSPPKNATSAVTT-GQHNITSSSTSSMSLRPSSISETLSPSTSDNSTS 665
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 268-522 5.35e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.28  E-value: 5.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 268 QTEASNRQIEASSRQTEASNRQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGASNRQIEASNRQIGASNRQTE 347
Cdd:COG3883   17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGERARALY 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 348 VSSRQI-------EASN-----RQIGASNRQTEASNRQIGA-SNRQTEASNRQIGASNRQTDASNRQTDASNRQTEASSR 414
Cdd:COG3883   97 RSGGSVsyldvllGSESfsdflDRLSALSKIADADADLLEElKADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQ 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 415 QTEASSRQTEASSRQTEASSRQIEASAAAVRPKKPRGKKGNNKGSNSASEPSEAPPAIQTVTNHALSVTVRIRRGSRARK 494
Cdd:COG3883  177 QAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAASAAGAGAAGAAG 256

                        250       260
                 ....*....|....*....|....*...
gi 595582098 495 AANKNRATESQAQIAEQGAQASEASISA 522
Cdd:COG3883  257 AAAGSAGAAGAAAGAAGAGAAAASAAGG 284
Tar COG0840
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
250-442 5.43e-04

Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];


Pssm-ID: 440602 [Multi-domain]  Cd Length: 533  Bit Score: 43.47  E-value: 5.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 250 EASNAIEASSRQIGASGRQTEASNRQIEASSRQTEASNRQTEASSRQTEASSRQTETSNRQIgasnRQIMASNRQIG--- 326
Cdd:COG0840  292 ETAAAMEELSATVQEVAENAQQAAELAEEASELAEEGGEVVEEAVEGIEEIRESVEETAETI----EELGESSQEIGeiv 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 327 -------------ASNRQIEAS------------------------------NRQIGASNRQTEVSSRQIEASNRQIGAS 363
Cdd:COG0840  368 dviddiaeqtnllALNAAIEAArageagrgfavvadevrklaersaeatkeiEELIEEIQSETEEAVEAMEEGSEEVEEG 447

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 364 NRQTEASN---RQIGASNRQTEASNRQIGASNRQTDASNRQTDASNRQTEASSRQTEASSRQTEASSRQTEASSRQIEAS 440
Cdd:COG0840  448 VELVEEAGealEEIVEAVEEVSDLIQEIAAASEEQSAGTEEVNQAIEQIAAAAQENAASVEEVAAAAEELAELAEELQEL 527


                 ..
gi 595582098 441 AA 442
Cdd:COG0840  528 VS 529
MSCRAMM_ClfA NF033609
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ...
 199-412 7.37e-04

MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.


Pssm-ID: 468110 [Multi-domain]  Cd Length: 934  Bit Score: 43.36  E-value: 7.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 199 ASAATHTVTTQGQAAKETGSIQTIAATARSKKNSKGKRTPAKTTNTDN-EYVEASNAIEASSRQIGASGRQTEASNRQIE 277
Cdd:NF033609  37 ADASENSVTQSDSASNESKSNDSSSVSAAPKTDDTNVSDTKTSSNTNNgETSVAQNPAQQETTQSASTNATTEETPVTGE 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 278 ASSRQTEASNRQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGASNRQIEASnrqigasnrqTEVSSRQIEASN 357
Cdd:NF033609 117 ATTTATNQANTPATTQSSNTNAEELVNQTSNETTSNDTNTVSSVNSPQNSTNAENVST----------TQDTSTEATPSN 186

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 595582098 358 RQigASNRQTEASNRQIGASNRQTEASN-RQIGASNRQTDASNRQTDASNRQTEAS 412
Cdd:NF033609 187 NE--SAPQSTDASNKDVVNQAVNTSAPRmRAFSLAAVAADAPAAGTDITNQLTNVT 240
PRK09039 PRK09039
peptidoglycan -binding protein;
259-380 1.56e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 41.49  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 259 SRQIgaSGRQTE--ASNRQIEASSRQ---TEASNRQTEASSRQTEASSRQTETSNRQIGASN----RQIMASNRQIGASN 329
Cdd:PRK09039  45 SREI--SGKDSAldRLNSQIAELADLlslERQGNQDLQDSVANLRASLSAAEAERSRLQALLaelaGAGAAAEGRAGELA 122

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 595582098 330 RQIeASNRQIGA-SNRQTEVSSRQIEASNRQIGASNRQTEASNRQIGASNRQ 380
Cdd:PRK09039 123 QEL-DSEKQVSArALAQVELLNQQIAALRRQLAALEAALDASEKRDRESQAK 173
PRK09039 PRK09039
peptidoglycan -binding protein;
250-360 2.17e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 41.10  E-value: 2.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 250 EASNAIEASSRQIGASGRQTEASNRQIEASsrQTEASNRQTEASSRQTEASsrQTETSNRQIGASnrqimaSNRQIGASN 329
Cdd:PRK09039  74 QGNQDLQDSVANLRASLSAAEAERSRLQAL--LAELAGAGAAAEGRAGELA--QELDSEKQVSAR------ALAQVELLN 143

                         90       100       110
                 ....*....|....*....|....*....|.
gi 595582098 330 RQIEASNRQIGASNRQTEVSSRQIEASNRQI 360
Cdd:PRK09039 144 QQIAALRRQLAALEAALDASEKRDRESQAKI 174
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
262-468 2.37e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 41.04  E-value: 2.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 262 IGASGRQTEASNRQIEASSRQTEASNRQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGASNRQIEASNRQIGA 341
Cdd:COG4372   26 IAALSEQLRKALFELDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELES 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 342 SNRQTEVSSRQIEASNRQIGASNRQTEASNRQIgasnrqteaSNRQIGASNRQTDASNRQTDASNRQTEASSRQTEASSR 421
Cdd:COG4372  106 LQEEAEELQEELEELQKERQDLEQQRKQLEAQI---------AELQSEIAEREEELKELEEQLESLQEELAALEQELQAL 176

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 595582098 422 QTEASSRQTEASSRQIEASAAAVRPKKPRGKKGNNKGSNSASEPSEA 468
Cdd:COG4372  177 SEAEAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEA 223
PTZ00121 PTZ00121
MAEBL; Provisional
 229-524 2.41e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 41.67  E-value: 2.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  229 KKNSKGKRTPAKTTNTDNEYVEASNAIEASSRQIGASGRQTEASNRQIEASSRQTEASNRQTEASSRQTEASSRQTETsn 308
Cdd:PTZ00121 1237 KDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEA-- 1314

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  309 rqigasnrqimasnRQIGASNRQIEASNRQIGASNRQTEVSSRQIEASNRQIGASNRQTEASNRQIGASNRQTEASNRQI 388
Cdd:PTZ00121 1315 --------------KKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKA 1380

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  389 GASNRQTDaSNRQTDASNRQTEASSRQTEASSRQTEASSRQTEASSRQIEASAAAVRPKKPRGKKGNNKGSNSASEPSEA 468
Cdd:PTZ00121 1381 DAAKKKAE-EKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKA 1459

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 595582098  469 PPAIqtvtnhalsvtvriRRGSRARKAANKNRATESQAQIAEQGAQASEASISALE 524
Cdd:PTZ00121 1460 EEAK--------------KKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADE 1501
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 319-404 3.28e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 3.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 319 MASNRQIGASNRQIEASNRQIGASNRQTEVSSRQIEASNRQIGASNRQTEASNRQIGASNRQTEASNRQIGASNRQTDAS 398
Cdd:COG4942   16 AAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAEL 95


                 ....*.
gi 595582098 399 NRQTDA 404
Cdd:COG4942   96 RAELEA 101
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
260-435 4.27e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 40.67  E-value: 4.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  260 RQIGASGRQTEASNRQIEASSRQTEASNRQTEASSRQTEASSRQtetsnRQIGASNRQImasnRQIGASNRQIEASNRQI 339
Cdd:COG4913   624 EELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAE-----REIAELEAEL----ERLDASSDDLAALEEQL 694

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  340 GASNRQTEVSSRQIEASNRQIGASNRQTEASNRQIGASNRQTEASNrQIGASNRQTDASNRQTDASNRQTEASSRQtEAS 419
Cdd:COG4913   695 EELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAE-DLARLELRALLEERFAAALGDAVERELRE-NLE 772

                         170
                  ....*....|....*.
gi 595582098  420 SRQTEASSRQTEASSR 435
Cdd:COG4913   773 ERIDALRARLNRAEEE 788
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 249-525 6.52e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.04  E-value: 6.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098   249 VEASNAIEASSRQIGASGRQTEASNRQIEASSRQTEASNRQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGAS 328
Cdd:TIGR02168  666 AKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL 745

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098   329 NRQIEASNRQIGASNRQTEVSSRQIEASNRQIGASNRQTEASNRQIGASNRQTEASNRQIGASNRQTDASNRqtdasnRQ 408
Cdd:TIGR02168  746 EERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNE------EA 819

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098   409 TEASSRQtEASSRQTEASSRQTEASSRQIEASAAAVrpkkprgkKGNNKGSNSASEP-SEAPPAIQTVTNHALSVTVRIR 487
Cdd:TIGR02168  820 ANLRERL-ESLERRIAATERRLEDLEEQIEELSEDI--------ESLAAEIEELEELiEELESELEALLNERASLEEALA 890

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 595582098   488 RG-SRARKAANKNRATESQAQIAEQGAQASEASISALET 525
Cdd:TIGR02168  891 LLrSELEELSEELRELESKRSELRRELEELREKLAQLEL 929
MscS_porin pfam12795
Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part ...
 250-437 6.61e-03

Mechanosensitive ion channel porin domain; The small mechanosensitive channel, MscS, is a part of the turgor-driven solute efflux system that protects bacteria from lysis in the event of osmotic shock. The MscS protein alone is sufficient to form a functional mechanosensitive channel gated directly by tension in the lipid bilayer. The MscS proteins are heptamers of three transmembrane subunits with seven converging M3 domains, and this MscS_porin is towards the N-terminal of the molecules. The high concentration of negative charges at the extracellular entrance of the pore helps select the cations for efflux.


Pssm-ID: 432790 [Multi-domain]  Cd Length: 238  Bit Score: 39.21  E-value: 6.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  250 EASNAIEASSRQIGASGRQTEASNRQIEASSRQTEASNRQTEASSRQTEASSRQTETSNRQIGASNRQIMASNRQIGASN 329
Cdd:pfam12795  48 DAPAELRELRQELAALQAKAEAAPKEILASLSLEELEQRLLQTSAQLQELQNQLAQLNSQLIELQTRPERAQQQLSEARQ 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  330 RQIEASNRQIGASNRQTEVSSRQIEASNRQIGASNRQTEASNR-QIGASNRQTEASNRQIGASNRQTDASNRQTDASNRQ 408
Cdd:pfam12795 128 RLQQIRNRLNGPAPPGEPLSEAQRWALQAELAALKAQIDMLEQeLLSNNNRQDLLKARRDLLTLRIQRLEQQLQALQELL 207

                         170       180
                  ....*....|....*....|....*....
gi 595582098  409 TEASSRQTEASSRQTEASSRQTEASSRQI 437
Cdd:pfam12795 208 NEKRLQEAEQAVAQTEQLAEEAAGDHPLV 236
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 323-448 7.46e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.05  E-value: 7.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098   323 RQIGASNRQIEASNRQIGASNRQTEVSSRQIEASNRQIGASNRQTEASNRQIgasNRQTEASNRQIGASNRQTDASNRQT 402
Cdd:TIGR02169  230 KEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKI---KDLGEEEQLRVKEKIGELEAEIASL 306

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 595582098   403 DASNRQTEASSRQTEASSRQTEASSRQTEASSRQIEASAAAVRPKK 448
Cdd:TIGR02169  307 ERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRR 352
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 29-297 8.09e-03

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 39.56  E-value: 8.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098   29 SPDVQSETTekdppiaSRSKKNKNKKNSIKPMDKTTPAPPPVPSANDNASNKPKVTLQALNLPmftQISQASATTEAPNI 108
Cdd:pfam17823  83 STEVTAEHT-------PHGTDLSEPATREGAADGAASRALAAAASSSPSSAAQSLPAAIAALP---SEAFSAPRAAACRA 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  109 QASVTSQTQKAKTMRVTPKVSLTGSEDATTQLKPPLQALNLP-----VTTPTIQTPVanesaNSLASTAVNKSKKASTAN 183
Cdd:pfam17823 153 NASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSApttaaSSAPATLTPA-----RGISTAATATGHPAAGTA 227

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098  184 NAANKTVPSAAEISLASAATHTVTTQGQAAKETGSIQTIAATARSKKNSKGKRTPAKTTNTDNeyveasnaieASSRQIG 263
Cdd:pfam17823 228 LAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPAKHMPSDT----------MARNPAA 297

                         250       260       270
                  ....*....|....*....|....*....|....
gi 595582098  264 ASGRQTEASNRQIEASSRQTEASNRQTEASSRQT 297
Cdd:pfam17823 298 PMGAQAQGPIIQVSTDQPVHNTAGEPTPSPSNTT 331
PHA03255 PHA03255
BDLF3; Provisional
 157-304 9.64e-03

BDLF3; Provisional


Pssm-ID: 165513 [Multi-domain]  Cd Length: 234  Bit Score: 38.73  E-value: 9.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 595582098 157 QTPVANESANSLASTAVNKSKKASTANNAANKTVPSAAEISLASAATHTVTTQGQAAKETGSIQTIAATARSKKNSKGKR 236
Cdd:PHA03255  19 ETSLIWTSSGSSTASAGNVTGTTAVTTPSPSASGPSTNQSTTLTTTSAPITTTAILSTNTTTVTSTGTTVTPVPTTSNAS 98

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 595582098 237 TPAKTTNTDNEYVEASNAieASSRQIGASGRQTEASNRQIEASSRQTEASNRQTEASSRQTEASSRQT 304
Cdd:PHA03255  99 TINVTTKVTAQNITATEA--GTGTSTGVTSNVTTRSSSTTSATTRITNATTLAPTLSSKGTSNATKTT 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH