NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|605052040|ref|NP_001278262|]
View 

tetratricopeptide repeat protein 4 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CTWD_Cns1-like super family cl40972
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo ...
 226-280 6.77e-19

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo sapiens tetratricopeptide repeat protein 4 (TTC4), and similar proteins; The family includes Hsp70/Hsp90 co-chaperone Cns1 from Saccharomyces cerevisiae and the human Cns1 homolog tetratricopeptide repeat protein 4 (TTC4), both of which contain a C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses.


The actual alignment was detected with superfamily member cd21380:

Pssm-ID: 454930  Cd Length: 153  Bit Score: 81.06  E-value: 6.77e-19
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 605052040 226 IKVYFEDEDRAELYRVPAKSTLLQVLQHQRYFVKALTPAFLVCVGSSPFCKNFLR 280
Cdd:cd21380   99 LNVYFEDRDKGKLVKVDPKSTLGEVLSHKRYVVKNGTPSFIVLVKGSEFEKEFLK 153
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
64-181 1.22e-11

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 63.01  E-value: 1.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040  64 LQSIIFDEERSPEEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAA 143
Cdd:COG4785   58 LAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALE---LDPD-LAEAYNNRGLAYLLLGDYDAALEDFDRA 133

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 605052040 144 RKLKPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQID 181
Cdd:COG4785  134 LELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELD 171
 
Name Accession Description Interval E-value
CTWD_Cns1 cd21380
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and ...
 226-280 6.77e-19

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and similar proteins; Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. The model corresponds to Cns1 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


Pssm-ID: 439174  Cd Length: 153  Bit Score: 81.06  E-value: 6.77e-19
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 605052040 226 IKVYFEDEDRAELYRVPAKSTLLQVLQHQRYFVKALTPAFLVCVGSSPFCKNFLR 280
Cdd:cd21380   99 LNVYFEDRDKGKLVKVDPKSTLGEVLSHKRYVVKNGTPSFIVLVKGSEFEKEFLK 153
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
64-181 1.22e-11

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 63.01  E-value: 1.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040  64 LQSIIFDEERSPEEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAA 143
Cdd:COG4785   58 LAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALE---LDPD-LAEAYNNRGLAYLLLGDYDAALEDFDRA 133

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 605052040 144 RKLKPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQID 181
Cdd:COG4785  134 LELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELD 171
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 57-171 7.87e-10

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 59.23  E-value: 7.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040   57 ENPDLACLQSIIFDEERSPEEQAKtYKDEGNDYFKEKDYKKAVISYTEGLKKKcADPdlnaVLYTNRAAAQYYLGNFRSA 136
Cdd:TIGR00990 106 ELPEIDESSVANLSEEERKKYAAK-LKEKGNKAYRNKDFNKAIKLYSKAIECK-PDP----VYYSNRAACHNALGDWEKV 179

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 605052040  137 LNDVTAARKLKPCHLKAIIRGALCHLELKHFAEAV 171
Cdd:TIGR00990 180 VEDTTAALELDPDYSKALNRRANAYDGLGKYADAL 214
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 79-160 1.58e-03

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 39.38  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040  79 AKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIR-G 157
Cdd:PLN03088   2 AKDLEDKAKEAFVDDDFALAVDLYTQAID---LDPN-NAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRkG 77


                 ...
gi 605052040 158 ALC 160
Cdd:PLN03088  78 TAC 80
 
Name Accession Description Interval E-value
CTWD_Cns1 cd21380
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and ...
 226-280 6.77e-19

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and similar proteins; Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. The model corresponds to Cns1 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


Pssm-ID: 439174  Cd Length: 153  Bit Score: 81.06  E-value: 6.77e-19
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 605052040 226 IKVYFEDEDRAELYRVPAKSTLLQVLQHQRYFVKALTPAFLVCVGSSPFCKNFLR 280
Cdd:cd21380   99 LNVYFEDRDKGKLVKVDPKSTLGEVLSHKRYVVKNGTPSFIVLVKGSEFEKEFLK 153
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
64-181 1.22e-11

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 63.01  E-value: 1.22e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040  64 LQSIIFDEERSPEEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAA 143
Cdd:COG4785   58 LAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALE---LDPD-LAEAYNNRGLAYLLLGDYDAALEDFDRA 133

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 605052040 144 RKLKPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQID 181
Cdd:COG4785  134 LELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELD 171
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 57-171 7.87e-10

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 59.23  E-value: 7.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040   57 ENPDLACLQSIIFDEERSPEEQAKtYKDEGNDYFKEKDYKKAVISYTEGLKKKcADPdlnaVLYTNRAAAQYYLGNFRSA 136
Cdd:TIGR00990 106 ELPEIDESSVANLSEEERKKYAAK-LKEKGNKAYRNKDFNKAIKLYSKAIECK-PDP----VYYSNRAACHNALGDWEKV 179

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 605052040  137 LNDVTAARKLKPCHLKAIIRGALCHLELKHFAEAV 171
Cdd:TIGR00990 180 VEDTTAALELDPDYSKALNRRANAYDGLGKYADAL 214
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
77-264 2.02e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.94  E-value: 2.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040  77 EQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIR 156
Cdd:COG0457   40 DDAEALYNLGLAYLRLGRYEEALADYEQALE---LDPD-DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040 157 GALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKAdkLKRIEQRDVRKANLKEKKERNQNEALLQAIKVYFEDEDRA 236
Cdd:COG0457  116 LGLALLELGRYDEAIEAYERALELDPDDADALYNLGIA--LEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAA 193

                        170       180
                 ....*....|....*....|....*...
gi 605052040 237 ELYRVPAKSTLLQVLQHQRYFVKALTPA 264
Cdd:COG0457  194 EVLLALLLALEQALRKKLAILTLAALAE 221
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
77-202 1.01e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 54.63  E-value: 1.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040  77 EQAKTYKDEGNDYFKEKDYKKAVISYTEGLKKkcaDPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIR 156
Cdd:COG0457    6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALEL---DPD-DAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 605052040 157 GALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKA-DKLKRIEQ 202
Cdd:COG0457   82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLAlLELGRYDE 128
CTWD_Cns1-like cd21377
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo ...
 224-280 2.67e-07

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo sapiens tetratricopeptide repeat protein 4 (TTC4), and similar proteins; The family includes Hsp70/Hsp90 co-chaperone Cns1 from Saccharomyces cerevisiae and the human Cns1 homolog tetratricopeptide repeat protein 4 (TTC4), both of which contain a C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses.


Pssm-ID: 439173  Cd Length: 159  Bit Score: 49.26  E-value: 2.67e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 605052040 224 QAIKVYFED--------------EDRAELYRVPAKSTLLQVLQHQRYFVKALTPAFLVCVGSSPFCKNFLR 280
Cdd:cd21377   89 DNLEVYYETnavkplpsesskagPKEKKWVRVDPDTTLGDVLAHPDYYVIPGIPVFYVVPKGSPFEKRFLK 159
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
77-252 3.09e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.39  E-value: 3.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040  77 EQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIR 156
Cdd:COG0457   74 DDAEALNNLGLALQALGRYEEALEDYDKALE---LDPD-DAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYN 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040 157 GALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKADKLKRIEQRDVRKANLKEKKERNQNEALLQAIKVYFEDEDRA 236
Cdd:COG0457  150 LGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALAL 229

                        170
                 ....*....|....*.
gi 605052040 237 ELYRVPAKSTLLQVLQ 252
Cdd:COG0457  230 LLALRLAALALYQYRA 245
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 89-254 6.73e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 49.73  E-value: 6.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040  89 YFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIRGALCHLELKHFA 168
Cdd:COG2956  120 YEQEGDWEKAIEVLERLLK---LGPE-NAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYE 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040 169 EAVNWCDEGLQIDAKEKKLLEMRAKAdkLKRIEQRDVRKANLKEKKERNQNEALLQAIKVYFEDEDRAElyrvPAKSTLL 248
Cdd:COG2956  196 EAIAALERALEQDPDYLPALPRLAEL--YEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLE----AALALLE 269


                 ....*.
gi 605052040 249 QVLQHQ 254
Cdd:COG2956  270 RQLRRH 275
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 61-241 1.26e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 49.61  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040  61 LACLQSIIfdeERSPEEqAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDV 140
Cdd:COG3914   98 LALYRRAL---ALNPDN-AEALFNLGNLLLALGRLEEALAALRRALA---LNPD-FAEAYLNLGEALRRLGRLEEAIAAL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040 141 TAARKLKPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQIDAKEKK----LLEMRAKADKLKRIEQRDVRKANLKEKKER 216
Cdd:COG3914  170 RRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADahsnLLFALRQACDWEVYDRFEELLAALARGPSE 249

                        170       180
                 ....*....|....*....|....*
gi 605052040 217 NQNEALLqaikvYFEDEDRAELYRV 241
Cdd:COG3914  250 LSPFALL-----YLPDDDPAELLAL 269
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
77-165 5.34e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 46.45  E-value: 5.34e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040  77 EQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDLNAVLYtNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIR 156
Cdd:COG4785  105 DLAEAYNNRGLAYLLLGDYDAALEDFDRALE---LDPDYAYAYL-NRGIALYYLGRYELAIADLEKALELDPNDPERALW 180


                 ....*....
gi 605052040 157 GALCHLELK 165
Cdd:COG4785  181 LYLAERKLD 189
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 70-202 1.56e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 46.14  E-value: 1.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040  70 DEERSPEEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPC 149
Cdd:COG3914   69 AAAAALLLLAALLELAALLLQALGRYEEALALYRRALA---LNPD-NAEALFNLGNLLLALGRLEEALAALRRALALNPD 144

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 605052040 150 HLKAIIRGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKA-DKLKRIEQ 202
Cdd:COG3914  145 FAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNAlQDLGRLEE 198
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 86-192 3.08e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 42.69  E-value: 3.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040  86 GNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIRGALCHLELK 165
Cdd:COG4235   24 GRAYLRLGRYDEALAAYEKALR---LDPD-NADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQG 99

                         90       100
                 ....*....|....*....|....*..
gi 605052040 166 HFAEAVNWCDEGLQIDAKEKKLLEMRA 192
Cdd:COG4235  100 DYAEAIAAWQKLLALLPADAPARLLEA 126
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
89-183 5.51e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 41.31  E-value: 5.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040  89 YFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALnDVTAARKLKPCHLKAIIRGALCHLELKHFA 168
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALE---LDPD-NADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYD 76

                         90
                 ....*....|....*
gi 605052040 169 EAVNWCDEGLQIDAK 183
Cdd:COG3063   77 EALAYLERALELDPS 91
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 76-220 5.60e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.10  E-value: 5.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040  76 EEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAII 155
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALE---LDPD-NPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARL 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 605052040 156 RGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKAdkLKRIEQRDVRKANLKEKKERNQNE 220
Cdd:COG4783   77 NLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARA--YRALGRPDEAIAALEKALELDPDD 139
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 76-181 4.74e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.94  E-value: 4.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040  76 EEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAII 155
Cdd:COG5010   51 AKAFAIESPSDNLYNKLGDFEESLALLEQALQ---LDPN-NPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYS 126

                         90       100
                 ....*....|....*....|....*.
gi 605052040 156 RGALCHLELKHFAEAVNWCDEGLQID 181
Cdd:COG5010  127 NLAALLLSLGQDDEAKAALQRALGTS 152
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 86-254 6.20e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.48  E-value: 6.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040  86 GNDYFKEKDYKKAVISYTEGLKKkcaDPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIRGALCHLELK 165
Cdd:COG2956   83 AQDYLKAGLLDRAEELLEKLLEL---DPD-DAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQG 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040 166 HFAEAVNWCDEGLQIDAKEKKLLEMRAKAdklkRIEQRDVRKA--NLKEKKERNQN--EALLQAIKVYFEDEDRAElyrv 241
Cdd:COG2956  159 DYDEAIEALEKALKLDPDCARALLLLAEL----YLEQGDYEEAiaALERALEQDPDylPALPRLAELYEKLGDPEE---- 230

                        170
                 ....*....|...
gi 605052040 242 pAKSTLLQVLQHQ 254
Cdd:COG2956  231 -ALELLRKALELD 242
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 79-160 1.58e-03

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 39.38  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040  79 AKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIR-G 157
Cdd:PLN03088   2 AKDLEDKAKEAFVDDDFALAVDLYTQAID---LDPN-NAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRkG 77


                 ...
gi 605052040 158 ALC 160
Cdd:PLN03088  78 TAC 80
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 76-202 1.60e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 39.33  E-value: 1.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040  76 EEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAII 155
Cdd:COG2956  141 PENAHAYCELAELYLEQGDYDEAIEALEKALK---LDPD-CARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALP 216

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 605052040 156 RGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKADKLKRIEQ 202
Cdd:COG2956  217 RLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEA 263
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 77-261 3.30e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.17  E-value: 3.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040  77 EQAKTYKDEGNDYFKEKDYKKAVISYTEGLKKkcaDPDLNAVLYtnrAAAQYYL--GNFRSALNDVTAARKLKPCHLKAI 154
Cdd:COG2956   40 ETVEAHLALGNLYRRRGEYDRAIRIHQKLLER---DPDRAEALL---ELAQDYLkaGLLDRAEELLEKLLELDPDDAEAL 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 605052040 155 IRGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKADklkrIEQRDVRKA--NLKE--KKERNQNEALLQAIKVYF 230
Cdd:COG2956  114 RLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELY----LEQGDYDEAieALEKalKLDPDCARALLLLAELYL 189

                        170       180       190
                 ....*....|....*....|....*....|.
gi 605052040 231 EDEDRAElyrvpAKSTLLQVLQHQRYFVKAL 261
Cdd:COG2956  190 EQGDYEE-----AIAALERALEQDPDYLPAL 215
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH