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Conserved domains on  [gi|632794847|ref|NP_001278847|]
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transcriptional adapter 2-alpha isoform b [Homo sapiens]

Protein Classification

transcriptional adapter( domain architecture ID 709052)

transcriptional adapter facilitates the assembly and activation of the transcriptional machinery at specific gene promoters or enhancer regions; similar to Homo sapiens transcriptional adapter 2-alpha, a component of the ATAC (Ada-Two-A-containing) complex, which is a protein complex involved in regulating chromatin accessibility and gene expression

Gene Ontology:  GO:0003677|GO:0008270

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5114 super family cl27155
Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics];
28-272 9.06e-50

Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics];


The actual alignment was detected with superfamily member COG5114:

Pssm-ID: 227445 [Multi-domain]  Cd Length: 432  Bit Score: 170.64  E-value: 9.06e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632794847  28 YIKCAECgpPPFFLCLQCFTRGFEYKKHQSDHTYEIM-TSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQMCTKT 106
Cdd:COG5114   20 FIKCNEC--PAVDLCLPCFVNGIETGVHSPYHGYRIIeTNSYPIGEEGWGADEELLLIECLDTLGLGNWEDIADYIGSRA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632794847 107 KEECEKHYMKHFINNPLF--ASTLLNLKQAEEAKTADTAIPFHSTDDPP----RPTFDSLLSRDMAGYMPARADFIEEFD 180
Cdd:COG5114   98 KEEIKSHYLKMYDESKYYplPDITQNIHVPQDEFLEQRRHRIETFELPPinprKPKASNPYCHEIQGYMPGRLEFDVEYM 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632794847 181 NYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKERQRRKKIIRDHGLINLRKFQLMERRYPKEVQDLYETMRRFARI 260
Cdd:COG5114  178 NEAEVPIKDMSFDGDKEELKKKLKNATLDIYNSRLTFRARRKHAIFGKNLMDYRNLQAKDKKRSKEECGLVNSIKWFARY 257

                        250
                 ....*....|..
gi 632794847 261 VGPVEHDKFIES 272
Cdd:COG5114  258 LTKSDFNVFFRD 269
 
Name Accession Description Interval E-value
COG5114 COG5114
Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics];
28-272 9.06e-50

Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics];


Pssm-ID: 227445 [Multi-domain]  Cd Length: 432  Bit Score: 170.64  E-value: 9.06e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632794847  28 YIKCAECgpPPFFLCLQCFTRGFEYKKHQSDHTYEIM-TSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQMCTKT 106
Cdd:COG5114   20 FIKCNEC--PAVDLCLPCFVNGIETGVHSPYHGYRIIeTNSYPIGEEGWGADEELLLIECLDTLGLGNWEDIADYIGSRA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632794847 107 KEECEKHYMKHFINNPLF--ASTLLNLKQAEEAKTADTAIPFHSTDDPP----RPTFDSLLSRDMAGYMPARADFIEEFD 180
Cdd:COG5114   98 KEEIKSHYLKMYDESKYYplPDITQNIHVPQDEFLEQRRHRIETFELPPinprKPKASNPYCHEIQGYMPGRLEFDVEYM 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632794847 181 NYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKERQRRKKIIRDHGLINLRKFQLMERRYPKEVQDLYETMRRFARI 260
Cdd:COG5114  178 NEAEVPIKDMSFDGDKEELKKKLKNATLDIYNSRLTFRARRKHAIFGKNLMDYRNLQAKDKKRSKEECGLVNSIKWFARY 257

                        250
                 ....*....|..
gi 632794847 261 VGPVEHDKFIES 272
Cdd:COG5114  258 LTKSDFNVFFRD 269
ZZ_ADA2 cd02335
Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and ...
 15-64 1.29e-17

Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.


Pssm-ID: 239075 [Multi-domain]  Cd Length: 49  Bit Score: 75.02  E-value: 1.29e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 632794847  15 PPCRGCSSYLME-PYIKCAECgpPPFFLCLQCFTRGFEYKKHQSDHTYEIM 64
Cdd:cd02335    1 YHCDYCSKDITGtIRIKCAEC--PDFDLCLECFSAGAEIGKHRNDHNYRVV 49
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
74-118 7.48e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 53.77  E-value: 7.48e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 632794847    74 SWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHF 118
Cdd:smart00717   3 EWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLL 47
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 74-118 1.18e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 50.19  E-value: 1.18e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 632794847   74 SWTAQEEMALLEAVMDCGfGNWQDVANQMCTKTKEECEKHYMKHF 118
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
 
Name Accession Description Interval E-value
COG5114 COG5114
Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics];
28-272 9.06e-50

Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics];


Pssm-ID: 227445 [Multi-domain]  Cd Length: 432  Bit Score: 170.64  E-value: 9.06e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632794847  28 YIKCAECgpPPFFLCLQCFTRGFEYKKHQSDHTYEIM-TSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQMCTKT 106
Cdd:COG5114   20 FIKCNEC--PAVDLCLPCFVNGIETGVHSPYHGYRIIeTNSYPIGEEGWGADEELLLIECLDTLGLGNWEDIADYIGSRA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632794847 107 KEECEKHYMKHFINNPLF--ASTLLNLKQAEEAKTADTAIPFHSTDDPP----RPTFDSLLSRDMAGYMPARADFIEEFD 180
Cdd:COG5114   98 KEEIKSHYLKMYDESKYYplPDITQNIHVPQDEFLEQRRHRIETFELPPinprKPKASNPYCHEIQGYMPGRLEFDVEYM 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632794847 181 NYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKERQRRKKIIRDHGLINLRKFQLMERRYPKEVQDLYETMRRFARI 260
Cdd:COG5114  178 NEAEVPIKDMSFDGDKEELKKKLKNATLDIYNSRLTFRARRKHAIFGKNLMDYRNLQAKDKKRSKEECGLVNSIKWFARY 257

                        250
                 ....*....|..
gi 632794847 261 VGPVEHDKFIES 272
Cdd:COG5114  258 LTKSDFNVFFRD 269
ZZ_ADA2 cd02335
Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and ...
 15-64 1.29e-17

Zinc finger, ZZ type. Zinc finger present in ADA2, a putative transcriptional adaptor, and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.


Pssm-ID: 239075 [Multi-domain]  Cd Length: 49  Bit Score: 75.02  E-value: 1.29e-17
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 632794847  15 PPCRGCSSYLME-PYIKCAECgpPPFFLCLQCFTRGFEYKKHQSDHTYEIM 64
Cdd:cd02335    1 YHCDYCSKDITGtIRIKCAEC--PDFDLCLECFSAGAEIGKHRNDHNYRVV 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 74-118 1.93e-10

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 55.27  E-value: 1.93e-10
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 632794847  74 SWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHF 118
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
74-118 7.48e-10

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 53.77  E-value: 7.48e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 632794847    74 SWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHF 118
Cdd:smart00717   3 EWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLL 47
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 74-118 1.18e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 50.19  E-value: 1.18e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 632794847   74 SWTAQEEMALLEAVMDCGfGNWQDVANQMCTKTKEECEKHYMKHF 118
Cdd:pfam00249   3 PWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
ZZ cd02249
Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ...
 17-64 2.34e-07

Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have other zinc-binding motifs as well, and the majority serve as scaffolds in pathways involving acetyltransferase, protein kinase, or ubiqitin-related activity. ZZ proteins can be grouped into the following functional classes: chromatin modifying, cytoskeletal scaffolding, ubiquitin binding or conjugating, and membrane receptor or ion-channel modifying proteins.


Pssm-ID: 239069 [Multi-domain]  Cd Length: 46  Bit Score: 46.66  E-value: 2.34e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 632794847  17 CRGCSSYLMEPYIKCAECgpPPFFLCLQCFTRGFeyKKHQSDHTYEIM 64
Cdd:cd02249    3 CDGCLKPIVGVRYHCLVC--EDFDLCSSCYAKGK--KGHPPDHSFTEI 46
RSC8 COG5259
RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / ...
 31-128 3.67e-05

RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227584 [Multi-domain]  Cd Length: 531  Bit Score: 44.88  E-value: 3.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632794847  31 CAECGPPPFF------------LCLQCFTRG-FEYKKHQSDHtYEIMTSDFPVlDPSWTAQEEMALLEAVMDCGfGNWQD 97
Cdd:COG5259  227 CSCCGNKSFNtryhnlraekynSCSECYDQGrFPSEFTSSDF-KPVTISLLIR-DKNWSRQELLLLLEGIEMYG-DDWDK 303

                         90       100       110
                 ....*....|....*....|....*....|.
gi 632794847  98 VANQMCTKTKEECekhyMKHFINNPLFASTL 128
Cdd:COG5259  304 VARHVGTKTKEQC----ILHFLQLPIEDNYL 330
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 75-101 7.91e-04

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 36.78  E-value: 7.91e-04
                         10        20
                 ....*....|....*....|....*..
gi 632794847  75 WTAQEEMALLEAVMDCGFGNWQDVANQ 101
Cdd:cd11660    3 WTDEEDEALVEGVEKYGVGNWAKILKD 29
ZZ_dah cd02345
Zinc finger, ZZ type. Zinc finger present in Drosophila dah and related proteins. The ZZ motif ...
 16-59 6.03e-03

Zinc finger, ZZ type. Zinc finger present in Drosophila dah and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dah (discontinuous actin hexagon) is a membrane associated protein essential for cortical furrow formation in Drosophila.


Pssm-ID: 239085  Cd Length: 49  Bit Score: 34.49  E-value: 6.03e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 632794847  16 PCRGCS-SYLMEPYIKCAECgpPPFFLCLQCFTRGFEYKKHQSDH 59
Cdd:cd02345    2 SCSACRkQDISGIRFPCQVC--RDYSLCLGCYTKGRETKRHNSLH 44
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 74-239 6.09e-03

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 38.23  E-value: 6.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632794847  74 SWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHymKHFINNPLFASTLLNLKQAEEAKTADTAIPFHST---D 150
Cdd:COG5147   22 SWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNR--WNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWStiaD 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 632794847 151 DPPRPTFDSLLSRdmagYMPARADF----------IEEFDNYAE----WDLR-DIDFVEDDSDILhaLKMAVVDIYHSRL 215
Cdd:COG5147  100 YKDRRTAQQCVER----YVNTLEDLssthdsklqrRNEFDKIDPfnenSARRpDIYEDELLEREV--NREASYRLRVPRV 173

                        170       180
                 ....*....|....*....|....
gi 632794847 216 KERQRRKKIIRDHGLINLRKFQLM 239
Cdd:COG5147  174 SKADVKPREKGEENNPDIEDLQEM 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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