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Conserved domains on  [gi|635574584|ref|NP_001278975|]
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neuromedin-U isoform 3 precursor [Homo sapiens]

Protein Classification

NMU domain-containing protein( domain architecture ID 10638104)

NMU domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NMU smart00084
Neuromedin U; Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth ...
119-141 1.26e-08

Neuromedin U; Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth muscle contraction and causes selective vasoconstriction. Like most other active peptides, it is proteolytically processed from a larger precursor protein. The mature peptides are 8 (NmU-8) to 25 (NmU-25) residues long and C- terminally amidated. The sequence of the C-terminal extremity of NmU is extremely well conserved in mammals, birds and amphibians.


:

Pssm-ID: 197507  Cd Length: 25  Bit Score: 47.90  E-value: 1.26e-08
                           10        20
                   ....*....|....*....|...
gi 635574584   119 VVEEFQSPFASQSRGYFLFRPRN 141
Cdd:smart00084   3 VDEEFQGPIASQSRGYFLFRPRN 25
 
Name Accession Description Interval E-value
NMU smart00084
Neuromedin U; Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth ...
119-141 1.26e-08

Neuromedin U; Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth muscle contraction and causes selective vasoconstriction. Like most other active peptides, it is proteolytically processed from a larger precursor protein. The mature peptides are 8 (NmU-8) to 25 (NmU-25) residues long and C- terminally amidated. The sequence of the C-terminal extremity of NmU is extremely well conserved in mammals, birds and amphibians.


Pssm-ID: 197507  Cd Length: 25  Bit Score: 47.90  E-value: 1.26e-08
                           10        20
                   ....*....|....*....|...
gi 635574584   119 VVEEFQSPFASQSRGYFLFRPRN 141
Cdd:smart00084   3 VDEEFQGPIASQSRGYFLFRPRN 25
NMU pfam02070
Neuromedin U;
119-141 5.17e-08

Neuromedin U;


Pssm-ID: 460435  Cd Length: 25  Bit Score: 46.39  E-value: 5.17e-08
                          10        20
                  ....*....|....*....|...
gi 635574584  119 VVEEFQSPFASQSRGYFLFRPRN 141
Cdd:pfam02070   3 VDEELQGPGAIQSRGYFLFRPRN 25
 
Name Accession Description Interval E-value
NMU smart00084
Neuromedin U; Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth ...
119-141 1.26e-08

Neuromedin U; Neuromedin U (NmU) is a vertebrate peptide which stimulates uterine smooth muscle contraction and causes selective vasoconstriction. Like most other active peptides, it is proteolytically processed from a larger precursor protein. The mature peptides are 8 (NmU-8) to 25 (NmU-25) residues long and C- terminally amidated. The sequence of the C-terminal extremity of NmU is extremely well conserved in mammals, birds and amphibians.


Pssm-ID: 197507  Cd Length: 25  Bit Score: 47.90  E-value: 1.26e-08
                           10        20
                   ....*....|....*....|...
gi 635574584   119 VVEEFQSPFASQSRGYFLFRPRN 141
Cdd:smart00084   3 VDEEFQGPIASQSRGYFLFRPRN 25
NMU pfam02070
Neuromedin U;
119-141 5.17e-08

Neuromedin U;


Pssm-ID: 460435  Cd Length: 25  Bit Score: 46.39  E-value: 5.17e-08
                          10        20
                  ....*....|....*....|...
gi 635574584  119 VVEEFQSPFASQSRGYFLFRPRN 141
Cdd:pfam02070   3 VDEELQGPGAIQSRGYFLFRPRN 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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