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nuclear respiratory factor 1 isoform 3 [Homo sapiens]
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
Nrf1_DNA-bind super family | cl11131 | NLS-binding and DNA-binding and dimerization domains of Nrf1; In Drosophila, the erect wing ... |
1-122 | 2.88e-91 | |||
NLS-binding and DNA-binding and dimerization domains of Nrf1; In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0, there is also an NLS domain at 88-116, and a DNA binding and dimerization domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity. The actual alignment was detected with superfamily member pfam10491: Pssm-ID: 463112 Cd Length: 213 Bit Score: 271.61 E-value: 2.88e-91
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Name | Accession | Description | Interval | E-value | |||
Nrf1_DNA-bind | pfam10491 | NLS-binding and DNA-binding and dimerization domains of Nrf1; In Drosophila, the erect wing ... |
1-122 | 2.88e-91 | |||
NLS-binding and DNA-binding and dimerization domains of Nrf1; In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0, there is also an NLS domain at 88-116, and a DNA binding and dimerization domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity. Pssm-ID: 463112 Cd Length: 213 Bit Score: 271.61 E-value: 2.88e-91
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Name | Accession | Description | Interval | E-value | |||
Nrf1_DNA-bind | pfam10491 | NLS-binding and DNA-binding and dimerization domains of Nrf1; In Drosophila, the erect wing ... |
1-122 | 2.88e-91 | |||
NLS-binding and DNA-binding and dimerization domains of Nrf1; In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0, there is also an NLS domain at 88-116, and a DNA binding and dimerization domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity. Pssm-ID: 463112 Cd Length: 213 Bit Score: 271.61 E-value: 2.88e-91
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