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Conserved domains on  [gi|646227328|ref|NP_001280166|]
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mediator of RNA polymerase II transcription subunit 15 isoform d [Homo sapiens]

Protein Classification

mediator complex subunit 15 domain-containing protein( domain architecture ID 707846)

mediator complex subunit 15 (MED15) domain-containing protein may be involved in bridging enhancers and promoters and most of the proteins bearing these domains are transcriptional coactivators

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Med15 super family cl26621
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
1-718 9.87e-119

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


The actual alignment was detected with superfamily member pfam09606:

Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 372.80  E-value: 9.87e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328    1 MRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASV-----------------SDPMNALQSLT 63
Cdd:pfam09606  11 LQQNGQTSTKNAREMENHVFAKARTKDEYLGTVARLILHVRDMSKKAAQQQQpqggqgnggmgggqqgmPDPINALQNLA 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328   64 GGPAAGAAGIGMPP---RGPGQSLGGMGSLGAMGQPMSlSGQPPPGTSGMaPHSMAVVSTATPQTQLQLQQVALQQQQQQ 140
Cdd:pfam09606  91 GQGTRPQMMGPMGPgpgGPMGQQMGGPGTASNLLASLG-RPQMPMGGAGF-PSQMSRVGRMQPGGQAGGMMQPSSGQPGS 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  141 QQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQqqqhliklHHQNQQQIQQQQQQLQRIAQLQL 220
Cdd:pfam09606 169 GTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMPPQMGVPGMPGPADAGA--------QMGQQAQANGGMNPQQMGGAPNQ 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  221 QQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQp 300
Cdd:pfam09606 241 VAMQQQQPQQQGQQSQLGMGINQMQQMPQGVGGGAGQGGPGQPMGPPGQQPGAMPNVMSIGDQNNYQQQQTRQQQQQQG- 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  301 lVSQAQALPGQMLytqpplkfvrAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQ 380
Cdd:pfam09606 320 -GNHPAAHQQQMN----------QSVGQGGQVVALGGLNHLETWNPGNFGGLGANPMQRGQPGMMSSPSPVPGQQVRQVT 388
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  381 SMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPG-PLNTPVNpSSVMSPAGSS 459
Cdd:pfam09606 389 PNQFMRQSPQPSVPSPQGPGSQPPQSHPGGMIPSPALIPSPSPQMSQQPAQQRTIGQDSPGgSLNTPGQ-SAVNSPLNPQ 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  460 qaEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEklkNDMAVPtpp 539
Cdd:pfam09606 468 --EEQLYREKYRQLTKYIEPLKRMIAKMENDPGDIDKMNKMKRLLEILSNPSSRIPLETLQKCEAALE---NQMGTP--- 539
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  540 pppvpptKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDE---RQSIPSVLQGEV 616
Cdd:pfam09606 540 -------REPPLNNPLLEAVLSNLQSPTGNHTLYRTFRPTLEALFGPDIKGLPIPAKQPRLELDDttgRQEIPHILQGEI 612
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  617 ARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQ 696
Cdd:pfam09606 613 ARLDQKFKVSLDPCAQSNNKTIKLICKLDDKNLPSVPPVAVSIPEDYPDQSPSCSLDEQEYNATPFLITVQKSLHARISK 692
                         730       740
                  ....*....|....*....|..
gi 646227328  697 LPDKHSVTALLNTWAQSVHQAC 718
Cdd:pfam09606 693 LPGLFSLSHLLDTWEMSVRQAC 714
 
Name Accession Description Interval E-value
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
1-718 9.87e-119

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 372.80  E-value: 9.87e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328    1 MRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASV-----------------SDPMNALQSLT 63
Cdd:pfam09606  11 LQQNGQTSTKNAREMENHVFAKARTKDEYLGTVARLILHVRDMSKKAAQQQQpqggqgnggmgggqqgmPDPINALQNLA 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328   64 GGPAAGAAGIGMPP---RGPGQSLGGMGSLGAMGQPMSlSGQPPPGTSGMaPHSMAVVSTATPQTQLQLQQVALQQQQQQ 140
Cdd:pfam09606  91 GQGTRPQMMGPMGPgpgGPMGQQMGGPGTASNLLASLG-RPQMPMGGAGF-PSQMSRVGRMQPGGQAGGMMQPSSGQPGS 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  141 QQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQqqqhliklHHQNQQQIQQQQQQLQRIAQLQL 220
Cdd:pfam09606 169 GTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMPPQMGVPGMPGPADAGA--------QMGQQAQANGGMNPQQMGGAPNQ 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  221 QQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQp 300
Cdd:pfam09606 241 VAMQQQQPQQQGQQSQLGMGINQMQQMPQGVGGGAGQGGPGQPMGPPGQQPGAMPNVMSIGDQNNYQQQQTRQQQQQQG- 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  301 lVSQAQALPGQMLytqpplkfvrAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQ 380
Cdd:pfam09606 320 -GNHPAAHQQQMN----------QSVGQGGQVVALGGLNHLETWNPGNFGGLGANPMQRGQPGMMSSPSPVPGQQVRQVT 388
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  381 SMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPG-PLNTPVNpSSVMSPAGSS 459
Cdd:pfam09606 389 PNQFMRQSPQPSVPSPQGPGSQPPQSHPGGMIPSPALIPSPSPQMSQQPAQQRTIGQDSPGgSLNTPGQ-SAVNSPLNPQ 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  460 qaEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEklkNDMAVPtpp 539
Cdd:pfam09606 468 --EEQLYREKYRQLTKYIEPLKRMIAKMENDPGDIDKMNKMKRLLEILSNPSSRIPLETLQKCEAALE---NQMGTP--- 539
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  540 pppvpptKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDE---RQSIPSVLQGEV 616
Cdd:pfam09606 540 -------REPPLNNPLLEAVLSNLQSPTGNHTLYRTFRPTLEALFGPDIKGLPIPAKQPRLELDDttgRQEIPHILQGEI 612
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  617 ARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQ 696
Cdd:pfam09606 613 ARLDQKFKVSLDPCAQSNNKTIKLICKLDDKNLPSVPPVAVSIPEDYPDQSPSCSLDEQEYNATPFLITVQKSLHARISK 692
                         730       740
                  ....*....|....*....|..
gi 646227328  697 LPDKHSVTALLNTWAQSVHQAC 718
Cdd:pfam09606 693 LPGLFSLSHLLDTWEMSVRQAC 714
 
Name Accession Description Interval E-value
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
1-718 9.87e-119

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 372.80  E-value: 9.87e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328    1 MRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASV-----------------SDPMNALQSLT 63
Cdd:pfam09606  11 LQQNGQTSTKNAREMENHVFAKARTKDEYLGTVARLILHVRDMSKKAAQQQQpqggqgnggmgggqqgmPDPINALQNLA 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328   64 GGPAAGAAGIGMPP---RGPGQSLGGMGSLGAMGQPMSlSGQPPPGTSGMaPHSMAVVSTATPQTQLQLQQVALQQQQQQ 140
Cdd:pfam09606  91 GQGTRPQMMGPMGPgpgGPMGQQMGGPGTASNLLASLG-RPQMPMGGAGF-PSQMSRVGRMQPGGQAGGMMQPSSGQPGS 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  141 QQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQqqqhliklHHQNQQQIQQQQQQLQRIAQLQL 220
Cdd:pfam09606 169 GTPNQMGPNGGPGQGQAGGMNGGQQGPMGGQMPPQMGVPGMPGPADAGA--------QMGQQAQANGGMNPQQMGGAPNQ 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  221 QQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQp 300
Cdd:pfam09606 241 VAMQQQQPQQQGQQSQLGMGINQMQQMPQGVGGGAGQGGPGQPMGPPGQQPGAMPNVMSIGDQNNYQQQQTRQQQQQQG- 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  301 lVSQAQALPGQMLytqpplkfvrAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQVSQSSLPMLSSPSPGQQVQTPQ 380
Cdd:pfam09606 320 -GNHPAAHQQQMN----------QSVGQGGQVVALGGLNHLETWNPGNFGGLGANPMQRGQPGMMSSPSPVPGQQVRQVT 388
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  381 SMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPG-PLNTPVNpSSVMSPAGSS 459
Cdd:pfam09606 389 PNQFMRQSPQPSVPSPQGPGSQPPQSHPGGMIPSPALIPSPSPQMSQQPAQQRTIGQDSPGgSLNTPGQ-SAVNSPLNPQ 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  460 qaEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEklkNDMAVPtpp 539
Cdd:pfam09606 468 --EEQLYREKYRQLTKYIEPLKRMIAKMENDPGDIDKMNKMKRLLEILSNPSSRIPLETLQKCEAALE---NQMGTP--- 539
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  540 pppvpptKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDE---RQSIPSVLQGEV 616
Cdd:pfam09606 540 -------REPPLNNPLLEAVLSNLQSPTGNHTLYRTFRPTLEALFGPDIKGLPIPAKQPRLELDDttgRQEIPHILQGEI 612
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 646227328  617 ARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQ 696
Cdd:pfam09606 613 ARLDQKFKVSLDPCAQSNNKTIKLICKLDDKNLPSVPPVAVSIPEDYPDQSPSCSLDEQEYNATPFLITVQKSLHARISK 692
                         730       740
                  ....*....|....*....|..
gi 646227328  697 LPDKHSVTALLNTWAQSVHQAC 718
Cdd:pfam09606 693 LPGLFSLSHLLDTWEMSVRQAC 714
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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