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Conserved domains on  [gi|657188862|ref|NP_001280668|]
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endothelial cell-specific chemotaxis regulator isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ECSCR super family cl24401
Endothelial cell-specific chemotaxis regulator; ECSCR, endothelial cell-specific chemotaxis ...
 101-203 3.57e-39

Endothelial cell-specific chemotaxis regulator; ECSCR, endothelial cell-specific chemotaxis regulator, is a family of proteins found in eukaryotes. It is also known as ARIA for apoptosis regulator through modulating IAP expression. It is a cell surface protein that regulates endothelial chemotaxis and tube formation, and interacts with filamin A. Filamin A anchors transmembrane proteins to the actin cytoskeleton becoming a scaffold for various signalling proteins. ECSCR is also known to interact with and regulate the function of several endothelial transmembrane molecules. It has been shown to play a role in angiogenesis, a complex process involving the migration, proliferation, and lumen formation of blood vessels by endothelial cells. ECSCR appears also to regulate endothelial apoptosis, probably through modulating proteasomal degradation of cIAP-1 and cIAP-2 in endothelial cells.


The actual alignment was detected with superfamily member pfam15820:

Pssm-ID: 292448  Cd Length: 104  Bit Score: 130.26  E-value: 3.57e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657188862  101 SLSMREDATILPSPTSETVLTVAAFGVISFIVILVVVVIILVGVVSLRFKCRKSKESEDPQKPGSSGLSESCSTANGEKD 180
Cdd:pfam15820   1 ALRIREDKPILPSPTSETVLTVAAFGVISFIIILVVVVIILVSVVSLRFKCRKNKESEDPQKPEICGLFESCSTAIGEKD 80

                          90       100
                  ....*....|....*....|....
gi 657188862  181 -SITLISMKNINMNNGKQSLSAEK 203
Cdd:pfam15820  81 tSITLISMKNINMNNNKGCPTAEK 104
 
Name Accession Description Interval E-value
ECSCR pfam15820
Endothelial cell-specific chemotaxis regulator; ECSCR, endothelial cell-specific chemotaxis ...
 101-203 3.57e-39

Endothelial cell-specific chemotaxis regulator; ECSCR, endothelial cell-specific chemotaxis regulator, is a family of proteins found in eukaryotes. It is also known as ARIA for apoptosis regulator through modulating IAP expression. It is a cell surface protein that regulates endothelial chemotaxis and tube formation, and interacts with filamin A. Filamin A anchors transmembrane proteins to the actin cytoskeleton becoming a scaffold for various signalling proteins. ECSCR is also known to interact with and regulate the function of several endothelial transmembrane molecules. It has been shown to play a role in angiogenesis, a complex process involving the migration, proliferation, and lumen formation of blood vessels by endothelial cells. ECSCR appears also to regulate endothelial apoptosis, probably through modulating proteasomal degradation of cIAP-1 and cIAP-2 in endothelial cells.


Pssm-ID: 292448  Cd Length: 104  Bit Score: 130.26  E-value: 3.57e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657188862  101 SLSMREDATILPSPTSETVLTVAAFGVISFIVILVVVVIILVGVVSLRFKCRKSKESEDPQKPGSSGLSESCSTANGEKD 180
Cdd:pfam15820   1 ALRIREDKPILPSPTSETVLTVAAFGVISFIIILVVVVIILVSVVSLRFKCRKNKESEDPQKPEICGLFESCSTAIGEKD 80

                          90       100
                  ....*....|....*....|....
gi 657188862  181 -SITLISMKNINMNNGKQSLSAEK 203
Cdd:pfam15820  81 tSITLISMKNINMNNNKGCPTAEK 104
 
Name Accession Description Interval E-value
ECSCR pfam15820
Endothelial cell-specific chemotaxis regulator; ECSCR, endothelial cell-specific chemotaxis ...
 101-203 3.57e-39

Endothelial cell-specific chemotaxis regulator; ECSCR, endothelial cell-specific chemotaxis regulator, is a family of proteins found in eukaryotes. It is also known as ARIA for apoptosis regulator through modulating IAP expression. It is a cell surface protein that regulates endothelial chemotaxis and tube formation, and interacts with filamin A. Filamin A anchors transmembrane proteins to the actin cytoskeleton becoming a scaffold for various signalling proteins. ECSCR is also known to interact with and regulate the function of several endothelial transmembrane molecules. It has been shown to play a role in angiogenesis, a complex process involving the migration, proliferation, and lumen formation of blood vessels by endothelial cells. ECSCR appears also to regulate endothelial apoptosis, probably through modulating proteasomal degradation of cIAP-1 and cIAP-2 in endothelial cells.


Pssm-ID: 292448  Cd Length: 104  Bit Score: 130.26  E-value: 3.57e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 657188862  101 SLSMREDATILPSPTSETVLTVAAFGVISFIVILVVVVIILVGVVSLRFKCRKSKESEDPQKPGSSGLSESCSTANGEKD 180
Cdd:pfam15820   1 ALRIREDKPILPSPTSETVLTVAAFGVISFIIILVVVVIILVSVVSLRFKCRKNKESEDPQKPEICGLFESCSTAIGEKD 80

                          90       100
                  ....*....|....*....|....
gi 657188862  181 -SITLISMKNINMNNGKQSLSAEK 203
Cdd:pfam15820  81 tSITLISMKNINMNNNKGCPTAEK 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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