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tetratricopeptide repeat protein 39A isoform 8 [Homo sapiens]
List of domain hits
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Name | Accession | Description | Interval | E-value | ||
Iml2-TPR_39 super family | cl28743 | Iml2/Tetratricopeptide repeat protein 39; This is a family of proteins conserved from fungi to ... |
1-59 | 2.99e-15 | ||
Iml2/Tetratricopeptide repeat protein 39; This is a family of proteins conserved from fungi to humans, including fungal Inclusion body clearance protein Iml2 protein, animal tetratricopeptide repeat protein 39A/B/C (TT39A/B/C) and some uncharacterized proteins. Members of this family carry a tetratricopeptide repeat pfam07719 at their C terminus. This entry includes Iml2 and its paralogue-YKR018C from S. cerevisiae; Iml2 localizes to the cytoplasm and nucleus, and its expression is increased in response to DNA replication stress. It is found to be involved in lipid droplet-mediated inclusion body clearing after protein folding stress. In humans, TTC39A (also known as DEME6) is expressed in primary breast carcinomas but not in normal breast tissue, and has a putative eukaryotic RNP-1 RNA binding region and a candidate anchoring transmembrane domain. It is coordinately regulated with oestrogen receptor, but is not necessarily oestradiol-responsive. TTC39B has been linked to lipid metabolism. The actual alignment was detected with superfamily member pfam10300: Pssm-ID: 463047 [Multi-domain] Cd Length: 469 Bit Score: 71.61 E-value: 2.99e-15
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Name | Accession | Description | Interval | E-value | ||
Iml2-TPR_39 | pfam10300 | Iml2/Tetratricopeptide repeat protein 39; This is a family of proteins conserved from fungi to ... |
1-59 | 2.99e-15 | ||
Iml2/Tetratricopeptide repeat protein 39; This is a family of proteins conserved from fungi to humans, including fungal Inclusion body clearance protein Iml2 protein, animal tetratricopeptide repeat protein 39A/B/C (TT39A/B/C) and some uncharacterized proteins. Members of this family carry a tetratricopeptide repeat pfam07719 at their C terminus. This entry includes Iml2 and its paralogue-YKR018C from S. cerevisiae; Iml2 localizes to the cytoplasm and nucleus, and its expression is increased in response to DNA replication stress. It is found to be involved in lipid droplet-mediated inclusion body clearing after protein folding stress. In humans, TTC39A (also known as DEME6) is expressed in primary breast carcinomas but not in normal breast tissue, and has a putative eukaryotic RNP-1 RNA binding region and a candidate anchoring transmembrane domain. It is coordinately regulated with oestrogen receptor, but is not necessarily oestradiol-responsive. TTC39B has been linked to lipid metabolism. Pssm-ID: 463047 [Multi-domain] Cd Length: 469 Bit Score: 71.61 E-value: 2.99e-15
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Name | Accession | Description | Interval | E-value | ||
Iml2-TPR_39 | pfam10300 | Iml2/Tetratricopeptide repeat protein 39; This is a family of proteins conserved from fungi to ... |
1-59 | 2.99e-15 | ||
Iml2/Tetratricopeptide repeat protein 39; This is a family of proteins conserved from fungi to humans, including fungal Inclusion body clearance protein Iml2 protein, animal tetratricopeptide repeat protein 39A/B/C (TT39A/B/C) and some uncharacterized proteins. Members of this family carry a tetratricopeptide repeat pfam07719 at their C terminus. This entry includes Iml2 and its paralogue-YKR018C from S. cerevisiae; Iml2 localizes to the cytoplasm and nucleus, and its expression is increased in response to DNA replication stress. It is found to be involved in lipid droplet-mediated inclusion body clearing after protein folding stress. In humans, TTC39A (also known as DEME6) is expressed in primary breast carcinomas but not in normal breast tissue, and has a putative eukaryotic RNP-1 RNA binding region and a candidate anchoring transmembrane domain. It is coordinately regulated with oestrogen receptor, but is not necessarily oestradiol-responsive. TTC39B has been linked to lipid metabolism. Pssm-ID: 463047 [Multi-domain] Cd Length: 469 Bit Score: 71.61 E-value: 2.99e-15
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