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Conserved domains on  [gi|666335562|ref|NP_001287938|]
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V-set and transmembrane domain-containing protein 2A isoform 2 precursor [Homo sapiens]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 12208729)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

CATH:  2.60.40.10
PubMed:  7932691|10436082

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 33-148 5.69e-11

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 57.13  E-value: 5.69e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335562    33 PRNVTATEGQNVEMSCAFqSGSASVYLeiqWWFLRGPEDLDPGaegagaqvellpdrdpdsdgtkiSTVKVQGNDISHKL 112
Cdd:smart00410   1 PPSVTVKEGESVTLSCEA-SGSPPPEV---TWYKQGGKLLAES-----------------------GRFSVSRSGSTSTL 53

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 666335562   113 QISKVRKKDEGLYECRVTDANYgelqEHKAQAYLKV 148
Cdd:smart00410  54 TISNVTPEDSGTYTCAATNSSG----SASSGTTLTV 85
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 33-148 5.69e-11

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 57.13  E-value: 5.69e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335562    33 PRNVTATEGQNVEMSCAFqSGSASVYLeiqWWFLRGPEDLDPGaegagaqvellpdrdpdsdgtkiSTVKVQGNDISHKL 112
Cdd:smart00410   1 PPSVTVKEGESVTLSCEA-SGSPPPEV---TWYKQGGKLLAES-----------------------GRFSVSRSGSTSTL 53

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 666335562   113 QISKVRKKDEGLYECRVTDANYgelqEHKAQAYLKV 148
Cdd:smart00410  54 TISNVTPEDSGTYTCAATNSSG----SASSGTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 31-138 6.97e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 52.08  E-value: 6.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335562   31 EFPRNVTATEGQNVEMSCAFQSGSASVYLEIQWwfLRGPEDLDPGAEGA----GAQVELLPDRdpdsdgtkistVKVQGN 106
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEASTSVYW--YRQPPGKGPTFLIAyysnGSEEGVKKGR-----------FSGRGD 67

                          90       100       110
                  ....*....|....*....|....*....|....
gi 666335562  107 DISHK--LQISKVRKKDEGLYECRVTDANYGELQ 138
Cdd:pfam07686  68 PSNGDgsLTIQNLTLSDSGTYTCAVIPSGEGVFG 101
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 30-127 1.43e-06

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 45.79  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335562  30 TEFPRNVTATEGQNVEMSCAFQSGSASVYleIQWWFLR---GPEDLdpgaegagaqVELLPDRDPDSDGTK--ISTVKVQ 104
Cdd:cd00099    2 TQSPRSLSVQEGESVTLSCEVSSSFSSTY--IYWYRQKpgqGPEFL----------IYLSSSKGKTKGGVPgrFSGSRDG 69

                         90       100
                 ....*....|....*....|...
gi 666335562 105 GNDIShkLQISKVRKKDEGLYEC 127
Cdd:cd00099   70 TSSFS--LTISNLQPEDSGTYYC 90
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 33-148 5.69e-11

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 57.13  E-value: 5.69e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335562    33 PRNVTATEGQNVEMSCAFqSGSASVYLeiqWWFLRGPEDLDPGaegagaqvellpdrdpdsdgtkiSTVKVQGNDISHKL 112
Cdd:smart00410   1 PPSVTVKEGESVTLSCEA-SGSPPPEV---TWYKQGGKLLAES-----------------------GRFSVSRSGSTSTL 53

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 666335562   113 QISKVRKKDEGLYECRVTDANYgelqEHKAQAYLKV 148
Cdd:smart00410  54 TISNVTPEDSGTYTCAATNSSG----SASSGTTLTV 85
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 31-138 6.97e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 52.08  E-value: 6.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335562   31 EFPRNVTATEGQNVEMSCAFQSGSASVYLEIQWwfLRGPEDLDPGAEGA----GAQVELLPDRdpdsdgtkistVKVQGN 106
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMSEASTSVYW--YRQPPGKGPTFLIAyysnGSEEGVKKGR-----------FSGRGD 67

                          90       100       110
                  ....*....|....*....|....*....|....
gi 666335562  107 DISHK--LQISKVRKKDEGLYECRVTDANYGELQ 138
Cdd:pfam07686  68 PSNGDgsLTIQNLTLSDSGTYTCAVIPSGEGVFG 101
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 30-127 1.43e-06

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 45.79  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335562  30 TEFPRNVTATEGQNVEMSCAFQSGSASVYleIQWWFLR---GPEDLdpgaegagaqVELLPDRDPDSDGTK--ISTVKVQ 104
Cdd:cd00099    2 TQSPRSLSVQEGESVTLSCEVSSSFSSTY--IYWYRQKpgqGPEFL----------IYLSSSKGKTKGGVPgrFSGSRDG 69

                         90       100
                 ....*....|....*....|...
gi 666335562 105 GNDIShkLQISKVRKKDEGLYEC 127
Cdd:cd00099   70 TSSFS--LTISNLQPEDSGTYYC 90
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 28-130 1.64e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 44.86  E-value: 1.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335562   28 KFTEFPRNVTATEGQNVEMSCAFQSGSASVYleiqWWFLRGPEDLDPgaegagaqvellpdrdpdsdgtkiSTVKVQGND 107
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPPTI----TWYKNGEPISSG------------------------STRSRSLSG 54

                          90       100
                  ....*....|....*....|...
gi 666335562  108 ISHKLQISKVRKKDEGLYECRVT 130
Cdd:pfam13927  55 SNSTLTISNVTRSDAGTYTCVAS 77
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 33-133 1.07e-05

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 42.57  E-value: 1.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335562   33 PRNVTATEGQNVEMSCAfqSGSASVYLEIQWWFlrgpedldpgaegaGAQVELLPDRDPDSDGTKISTVkvqgndishkL 112
Cdd:pfam00047   3 PPTVTVLEGDSATLTCS--ASTGSPGPDVTWSK--------------EGGTLIESLKVKHDNGRTTQSS----------L 56

                          90       100
                  ....*....|....*....|.
gi 666335562  113 QISKVRKKDEGLYECRVTDAN 133
Cdd:pfam00047  57 LISNVTKEDAGTYTCVVNNPG 77
I-set pfam07679
Immunoglobulin I-set domain;
28-148 2.50e-05

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 41.86  E-value: 2.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335562   28 KFTEFPRNVTATEGQNVEMSCAFqSGSASvyLEIQWwfLRGPEDLDPGaegagaqvellpdrdpdsdgtkiSTVKVQGND 107
Cdd:pfam07679   2 KFTQKPKDVEVQEGESARFTCTV-TGTPD--PEVSW--FKDGQPLRSS-----------------------DRFKVTYEG 53

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 666335562  108 ISHKLQISKVRKKDEGLYECRVTDAnYGElQEHKAQayLKV 148
Cdd:pfam07679  54 GTYTLTISNVQPDDSGKYTCVATNS-AGE-AEASAE--LTV 90
IgI_VEGFR_like cd05742
Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and ...
 34-142 1.05e-03

Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins; member of the I-set of IgSF domains; The members here are composed of the immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and related proteins. The VEGFRs have an extracellular component with seven Ig-like domains, a transmembrane segment, and an intracellular tyrosine kinase domain interrupted by a kinase-insert domain. The VEGFR family consists of three members: VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1) and VEGFR-3 (Flt-4). VEGF-A interacts with both VEGFR-1 and VEGFR-2. VEGFR-1 binds strongest to VEGF; VEGF-2 binds more weakly. VEGFR-3 appears not to bind VEGF, but binds other members of the VEGF family (VEGF-C and -D). VEGFRs bind VEGFs with high affinity with the IG-like domains. VEGF-A is important to the growth and maintenance of vascular endothelial cells and to the development of new blood- and lymphatic-vessels in physiological and pathological states. VEGFR-2 is a major mediator of the mitogenic, angiogenic, and microvascular permeability-enhancing effects of VEGF-A. VEGFR-1 may play an inhibitory part in these processes by binding VEGF and interfering with its interaction with VEGFR-2. VEGFR-1 has a signaling role in mediating monocyte chemotaxis. VEGFR-1 and VEGFR-2 may mediate a chemotactic and a survival signal in hematopoietic stem cells or leukemia cells. VEGFR-3 has been shown to be involved in tumor angiogenesis and growth. This group also contains alpha-type platelet-derived growth factor receptor precursor (PDGFR)-alpha (CD140a), and PDGFR-beta (CD140b). PDGFRs alpha and beta have an extracellular component with five Ig-like domains, a transmembrane segment, and a cytoplasmic portion that has protein tyrosine kinase activity.


Pssm-ID: 409404  Cd Length: 102  Bit Score: 37.52  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335562  34 RNVTATEGQNVEMSCAfQSGSASVYLEIQWwflrgpedLDPGAEgAGAQVELLPDRD-PDSDGTKISTVkvqgndishkL 112
Cdd:cd05742   10 EPTVLPQGETLVLNCT-ANVNLNEVVDFQW--------TYPSEK-EGKLALLKPDIKvDWSEPGEFVST----------L 69

                         90       100       110
                 ....*....|....*....|....*....|
gi 666335562 113 QISKVRKKDEGLYECRvtdANYGELQEHKA 142
Cdd:cd05742   70 TIPEATLKDSGTYTCA---ARSGVMKKEKQ 96
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 33-138 2.81e-03

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 36.22  E-value: 2.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335562  33 PRNVTATEGQNVEMSCAFQSGSASV--YLEIQwwflrgpedldpgaEGAGAQveLLPDRDPDSDGTKIStVKVQGNDISH 110
Cdd:cd05716    4 PEVVTGVEGGSVTIQCPYPPKYASSrkYWCKW--------------GSEGCQ--TLVSSEGVVPGGRIS-LTDDPDNGVF 66

                         90       100
                 ....*....|....*....|....*...
gi 666335562 111 KLQISKVRKKDEGLYECRVTDANYGELQ 138
Cdd:cd05716   67 TVTLNQLRKEDAGWYWCGVGDDGDRGLT 94
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 94-136 3.48e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 35.38  E-value: 3.48e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 666335562  94 DGTKISTVKVQGNDI---SHKLQISKVRKKDEGLYECRVTDANYGE 136
Cdd:cd00096   20 NGKPLPPSSRDSRRSelgNGTLTISNVTLEDSGTYTCVASNSAGGS 65
IGv smart00406
Immunoglobulin V-Type;
43-127 4.21e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 35.44  E-value: 4.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 666335562    43 NVEMSCAFqSGSASVYLEIQWwfLRgpedldpgaEGAGAQVELLPDRDPDSDGTKISTVK--VQGNDISHK----LQISK 116
Cdd:smart00406   1 SVTLSCKF-SGSTFSSYYVSW--VR---------QPPGKGLEWLGYIGSNGSSYYQESYKgrFTISKDTSKndvsLTISN 68

                           90
                   ....*....|.
gi 666335562   117 VRKKDEGLYEC 127
Cdd:smart00406  69 LRVEDTGTYYC 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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