![](files/infoQ.gif)
sn-1-specific diacylglycerol lipase ABHD11 isoform 9 [Homo sapiens]
alpha/beta fold hydrolase( domain architecture ID 11426811)
alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad
List of domain hits
![](files/help.png)
Name | Accession | Description | Interval | E-value | |||
MenH | COG0596 | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ... |
58-145 | 1.27e-22 | |||
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis : Pssm-ID: 440361 [Multi-domain] Cd Length: 221 Bit Score: 88.90 E-value: 1.27e-22
|
|||||||
Name | Accession | Description | Interval | E-value | |||
MenH | COG0596 | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ... |
58-145 | 1.27e-22 | |||
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis Pssm-ID: 440361 [Multi-domain] Cd Length: 221 Bit Score: 88.90 E-value: 1.27e-22
|
|||||||
PRK10673 | PRK10673 | esterase; |
44-141 | 2.52e-22 | |||
esterase; Pssm-ID: 182637 [Multi-domain] Cd Length: 255 Bit Score: 89.02 E-value: 2.52e-22
|
|||||||
Abhydrolase_1 | pfam00561 | alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes. |
58-148 | 1.81e-15 | |||
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes. Pssm-ID: 395444 [Multi-domain] Cd Length: 245 Bit Score: 70.61 E-value: 1.81e-15
|
|||||||
Lipase_3 | cd00519 | Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into ... |
107-143 | 7.94e-03 | |||
Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of becoming active at the lipid/water interface, although several examples of lipases have been identified that do not undergo interfacial activation . The active site of a lipase contains a catalytic triad consisting of Ser - His - Asp/Glu, but unlike most serine proteases, the active site is buried inside the structure. A "lid" or "flap" covers the active site, making it inaccessible to solvent and substrates. The lid opens during the process of interfacial activation, allowing the lipid substrate access to the active site. Pssm-ID: 238287 [Multi-domain] Cd Length: 229 Bit Score: 35.14 E-value: 7.94e-03
|
|||||||
Name | Accession | Description | Interval | E-value | |||
MenH | COG0596 | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ... |
58-145 | 1.27e-22 | |||
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis Pssm-ID: 440361 [Multi-domain] Cd Length: 221 Bit Score: 88.90 E-value: 1.27e-22
|
|||||||
PRK10673 | PRK10673 | esterase; |
44-141 | 2.52e-22 | |||
esterase; Pssm-ID: 182637 [Multi-domain] Cd Length: 255 Bit Score: 89.02 E-value: 2.52e-22
|
|||||||
Abhydrolase_1 | pfam00561 | alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes. |
58-148 | 1.81e-15 | |||
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes. Pssm-ID: 395444 [Multi-domain] Cd Length: 245 Bit Score: 70.61 E-value: 1.81e-15
|
|||||||
PldB | COG2267 | Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism]; |
48-149 | 2.60e-13 | |||
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism]; Pssm-ID: 441868 [Multi-domain] Cd Length: 221 Bit Score: 64.25 E-value: 2.60e-13
|
|||||||
PRK11126 | PRK11126 | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional |
58-144 | 7.11e-12 | |||
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Provisional Pssm-ID: 236855 [Multi-domain] Cd Length: 242 Bit Score: 60.62 E-value: 7.11e-12
|
|||||||
PRK14875 | PRK14875 | acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional |
53-147 | 1.60e-10 | |||
acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional Pssm-ID: 184875 [Multi-domain] Cd Length: 371 Bit Score: 57.65 E-value: 1.60e-10
|
|||||||
FrsA | COG1073 | Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ... |
52-148 | 3.85e-10 | |||
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; Pssm-ID: 440691 [Multi-domain] Cd Length: 253 Bit Score: 56.08 E-value: 3.85e-10
|
|||||||
Hydrolase_4 | pfam12146 | Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ... |
59-148 | 4.06e-10 | |||
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2. Pssm-ID: 463473 [Multi-domain] Cd Length: 238 Bit Score: 56.07 E-value: 4.06e-10
|
|||||||
DAP2 | COG1506 | Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]; |
52-146 | 3.72e-09 | |||
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]; Pssm-ID: 441115 [Multi-domain] Cd Length: 234 Bit Score: 53.10 E-value: 3.72e-09
|
|||||||
EstA | COG1075 | Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ... |
60-135 | 1.56e-08 | |||
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism]; Pssm-ID: 440693 [Multi-domain] Cd Length: 106 Bit Score: 49.44 E-value: 1.56e-08
|
|||||||
DLH | COG0412 | Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism]; |
52-147 | 1.59e-08 | |||
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism]; Pssm-ID: 440181 [Multi-domain] Cd Length: 226 Bit Score: 51.51 E-value: 1.59e-08
|
|||||||
YvaK | COG1647 | Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism]; |
58-148 | 5.62e-08 | |||
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism]; Pssm-ID: 441253 [Multi-domain] Cd Length: 246 Bit Score: 49.94 E-value: 5.62e-08
|
|||||||
Aes | COG0657 | Acetyl esterase/lipase [Lipid transport and metabolism]; |
48-150 | 3.62e-07 | |||
Acetyl esterase/lipase [Lipid transport and metabolism]; Pssm-ID: 440422 [Multi-domain] Cd Length: 207 Bit Score: 47.56 E-value: 3.62e-07
|
|||||||
Abhydrolase_6 | pfam12697 | Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ... |
60-142 | 3.65e-07 | |||
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity. Pssm-ID: 463673 [Multi-domain] Cd Length: 211 Bit Score: 47.47 E-value: 3.65e-07
|
|||||||
PGAP1 | pfam07819 | PGAP1-like protein; The sequences found in this family are similar to PGAP1. This is an ... |
60-141 | 9.60e-07 | |||
PGAP1-like protein; The sequences found in this family are similar to PGAP1. This is an endoplasmic reticulum membrane protein with a catalytic serine containing motif that is conserved in a number of lipases. PGAP1 functions as a GPI inositol-deacylase; this deacylation is important for the efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi body. This entry also includes Tgl2, a mitochondria protein that serves as a triacylglycerol lipase in budding yeasts. Pssm-ID: 369540 Cd Length: 233 Bit Score: 46.59 E-value: 9.60e-07
|
|||||||
COG4188 | COG4188 | Predicted dienelactone hydrolase [General function prediction only]; |
41-149 | 3.29e-06 | |||
Predicted dienelactone hydrolase [General function prediction only]; Pssm-ID: 443342 [Multi-domain] Cd Length: 326 Bit Score: 45.10 E-value: 3.29e-06
|
|||||||
PLN02980 | PLN02980 | 2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate ... |
60-146 | 5.98e-06 | |||
2-oxoglutarate decarboxylase/ hydro-lyase/ magnesium ion binding / thiamin pyrophosphate binding Pssm-ID: 215530 [Multi-domain] Cd Length: 1655 Bit Score: 44.85 E-value: 5.98e-06
|
|||||||
COG4757 | COG4757 | Predicted alpha/beta hydrolase [General function prediction only]; |
45-146 | 2.52e-05 | |||
Predicted alpha/beta hydrolase [General function prediction only]; Pssm-ID: 443790 [Multi-domain] Cd Length: 289 Bit Score: 42.56 E-value: 2.52e-05
|
|||||||
PRK10566 | PRK10566 | esterase; Provisional |
56-139 | 3.69e-05 | |||
esterase; Provisional Pssm-ID: 182555 [Multi-domain] Cd Length: 249 Bit Score: 41.90 E-value: 3.69e-05
|
|||||||
Lipase_3 | pfam01764 | Lipase (class 3); |
107-143 | 2.87e-03 | |||
Lipase (class 3); Pssm-ID: 396362 [Multi-domain] Cd Length: 139 Bit Score: 35.70 E-value: 2.87e-03
|
|||||||
Chlorophyllase | pfam07224 | Chlorophyllase; This family consists of several plant specific Chlorophyllase proteins (EC:3.1. ... |
39-143 | 7.14e-03 | |||
Chlorophyllase; This family consists of several plant specific Chlorophyllase proteins (EC:3.1.1.14). Chlorophyllase (Chlase) is the first enzyme involved in chlorophyll (Chl) degradation and catalyzes the hydrolysis of ester bond to yield chlorophyllide and phytol. Pssm-ID: 254111 Cd Length: 307 Bit Score: 35.59 E-value: 7.14e-03
|
|||||||
Lipase_3 | cd00519 | Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into ... |
107-143 | 7.94e-03 | |||
Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the process of becoming active at the lipid/water interface, although several examples of lipases have been identified that do not undergo interfacial activation . The active site of a lipase contains a catalytic triad consisting of Ser - His - Asp/Glu, but unlike most serine proteases, the active site is buried inside the structure. A "lid" or "flap" covers the active site, making it inaccessible to solvent and substrates. The lid opens during the process of interfacial activation, allowing the lipid substrate access to the active site. Pssm-ID: 238287 [Multi-domain] Cd Length: 229 Bit Score: 35.14 E-value: 7.94e-03
|
|||||||
Blast search parameters | ||||
|