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Conserved domains on  [gi|667667684|ref|NP_001288090|]
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cadherin-related family member 3 isoform 2 [Homo sapiens]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 377-473 4.09e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 4.09e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684 377 SYVFDVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGAslqyPNVFWINPKTGELQLVTKVDCETTPIYILRIQATN 455
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVtYSIVSGNE----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|.
gi 667667684 456 NED---TSSVTVTVNILEEND 473
Cdd:cd11304   77 GGGpplSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 154-253 6.13e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 6.13e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684 154 VYTVLEELSPGTIVANITAEDPdDEGFPSHLLYSIT--TVSKYFMINQLTGTIQVAQRIDRDagelrQNPTISLEVLVKD 231
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDP-DSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|..
gi 667667684 232 RPYGGQENRIQITFIVEDVNDN 253
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 53-143 1.33e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.34  E-value: 1.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684  53 HLYIVERANPG-FIYQVEAFDPeDTSRNIPLSYFLISPPKS--FRMSAN-GTLFSTTELDFEAgHRSFHLIVEVRDSGG- 127
Cdd:cd11304    3 EVSVPENAPPGtVVLTVSATDP-DSGENGEVTYSIVSGNEDglFSIDPStGEITTAKPLDREE-QSSYTLTVTATDGGGp 80

                         90
                 ....*....|....*..
gi 667667684 128 -LKASTELQVNIVNLND 143
Cdd:cd11304   81 pLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 482-591 5.07e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 51.16  E-value: 5.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684 482 SYFLALPVDLKVGTNIqnFKLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGsnvtRLLLTSRFDYaggfDKIWDYKL 560
Cdd:cd11304    1 SYEVSVPENAPPGTVV--LTVSATDPDSGENGeVTYSIVSGNEDGLFSIDPSTG----EITTAKPLDR----EEQSSYTL 70

                         90       100       110
                 ....*....|....*....|....*....|.
gi 667667684 561 LVYVTDDNLMSdrkkaealvETGTVTLSIKV 591
Cdd:cd11304   71 TVTATDGGGPP---------LSSTATVTITV 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 377-473 4.09e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 4.09e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684 377 SYVFDVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGAslqyPNVFWINPKTGELQLVTKVDCETTPIYILRIQATN 455
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVtYSIVSGNE----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|.
gi 667667684 456 NED---TSSVTVTVNILEEND 473
Cdd:cd11304   77 GGGpplSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 154-253 6.13e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 6.13e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684 154 VYTVLEELSPGTIVANITAEDPdDEGFPSHLLYSIT--TVSKYFMINQLTGTIQVAQRIDRDagelrQNPTISLEVLVKD 231
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDP-DSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|..
gi 667667684 232 RPYGGQENRIQITFIVEDVNDN 253
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
378-469 1.77e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 1.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684  378 YVFDVSERRPARTRVGQVRATDKDLPQ-SSLLYSISTGGASlqypNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN 456
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPnGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 667667684  457 E---DTSSVTVTVNIL 469
Cdd:pfam00028  77 GgppLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 396-476 4.72e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.76  E-value: 4.72e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684   396 RATDKDLPQSSLL-YSISTGGAslqyPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN---EDTSSVTVTVNILEE 471
Cdd:smart00112   1 SATDADSGENGKVtYSILSGND----DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDV 76


                   ....*
gi 667667684   472 NDEKP 476
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 53-143 1.33e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.34  E-value: 1.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684  53 HLYIVERANPG-FIYQVEAFDPeDTSRNIPLSYFLISPPKS--FRMSAN-GTLFSTTELDFEAgHRSFHLIVEVRDSGG- 127
Cdd:cd11304    3 EVSVPENAPPGtVVLTVSATDP-DSGENGEVTYSIVSGNEDglFSIDPStGEITTAKPLDREE-QSSYTLTVTATDGGGp 80

                         90
                 ....*....|....*..
gi 667667684 128 -LKASTELQVNIVNLND 143
Cdd:cd11304   81 pLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 171-254 2.23e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 2.23e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684   171 TAEDPDDeGFPSHLLYSIT--TVSKYFMINQLTGTIQVAQRIDRDagelrQNPTISLEVLVKDRPYGGQENRIQITFIVE 248
Cdd:smart00112   1 SATDADS-GENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDRE-----EQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*.
gi 667667684   249 DVNDNP 254
Cdd:smart00112  75 DVNDNA 80
Cadherin pfam00028
Cadherin domain;
153-248 6.81e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.54  E-value: 6.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684  153 RVYTVLEELSPGTIVANITAEDPdDEGFPSHLLYSITT--VSKYFMINQLTGTIQVAQRIDRDagelrQNPTISLEVLVK 230
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDP-DLGPNGRIFYSILGggPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 667667684  231 DRPYGGQENRIQITFIVE 248
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 70-146 3.84e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.20  E-value: 3.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684    70 AFDPeDTSRNIPLSYFLIS--PPKSFRMSAN-GTLFSTTELDFEAGHRsFHLIVEVRDSGG--LKASTELQVNIVNLNDE 144
Cdd:smart00112   2 ATDA-DSGENGKVTYSILSgnDDGLFSIDPEtGEITTTKPLDREEQPE-YTLTVEATDGGGppLSSTATVTITVLDVNDN 79


                   ..
gi 667667684   145 VP 146
Cdd:smart00112  80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 482-591 5.07e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 51.16  E-value: 5.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684 482 SYFLALPVDLKVGTNIqnFKLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGsnvtRLLLTSRFDYaggfDKIWDYKL 560
Cdd:cd11304    1 SYEVSVPENAPPGTVV--LTVSATDPDSGENGeVTYSIVSGNEDGLFSIDPSTG----EITTAKPLDR----EEQSSYTL 70

                         90       100       110
                 ....*....|....*....|....*....|.
gi 667667684 561 LVYVTDDNLMSdrkkaealvETGTVTLSIKV 591
Cdd:cd11304   71 TVTATDGGGPP---------LSSTATVTITV 92
Cadherin pfam00028
Cadherin domain;
53-138 1.27e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.99  E-value: 1.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684   53 HLYIVERANPG-FIYQVEAFDPeDTSRNIPLSYFLIS--PPKSFRM-SANGTLFSTTELDFEAGhRSFHLIVEVRDSGGL 128
Cdd:pfam00028   2 SASVPENAPVGtEVLTVTATDP-DLGPNGRIFYSILGggPGGNFRIdPDTGDISTTKPLDRESI-GEYELTVEATDSGGP 79

                          90
                  ....*....|
gi 667667684  129 KASTELQVNI 138
Cdd:pfam00028  80 PLSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
483-591 5.21e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.59  E-value: 5.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684  483 YFLALPVDLKVGTNIQNfkLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGSnvtrLLLTSRFDYaggfDKIWDYKLL 561
Cdd:pfam00028   1 YSASVPENAPVGTEVLT--VTATDPDLGPNGrIFYSILGGGPGGNFRIDPDTGD----ISTTKPLDR----ESIGEYELT 70

                          90       100       110
                  ....*....|....*....|....*....|
gi 667667684  562 VYVTDDNLMSDrkkaealveTGTVTLSIKV 591
Cdd:pfam00028  71 VEATDSGGPPL---------SSTATVTITV 91
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 377-473 4.09e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 91.61  E-value: 4.09e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684 377 SYVFDVSERRPARTRVGQVRATDKDLPQSSLL-YSISTGGAslqyPNVFWINPKTGELQLVTKVDCETTPIYILRIQATN 455
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVtYSIVSGNE----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|.
gi 667667684 456 NED---TSSVTVTVNILEEND 473
Cdd:cd11304   77 GGGpplSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 154-253 6.13e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 82.36  E-value: 6.13e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684 154 VYTVLEELSPGTIVANITAEDPdDEGFPSHLLYSIT--TVSKYFMINQLTGTIQVAQRIDRDagelrQNPTISLEVLVKD 231
Cdd:cd11304    3 EVSVPENAPPGTVVLTVSATDP-DSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDRE-----EQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|..
gi 667667684 232 RPYGGQENRIQITFIVEDVNDN 253
Cdd:cd11304   77 GGGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
378-469 1.77e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 75.03  E-value: 1.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684  378 YVFDVSERRPARTRVGQVRATDKDLPQ-SSLLYSISTGGASlqypNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN 456
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPnGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*.
gi 667667684  457 E---DTSSVTVTVNIL 469
Cdd:pfam00028  77 GgppLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 396-476 4.72e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.76  E-value: 4.72e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684   396 RATDKDLPQSSLL-YSISTGGAslqyPNVFWINPKTGELQLVTKVDCETTPIYILRIQATNN---EDTSSVTVTVNILEE 471
Cdd:smart00112   1 SATDADSGENGKVtYSILSGND----DGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDV 76


                   ....*
gi 667667684   472 NDEKP 476
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 53-143 1.33e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.34  E-value: 1.33e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684  53 HLYIVERANPG-FIYQVEAFDPeDTSRNIPLSYFLISPPKS--FRMSAN-GTLFSTTELDFEAgHRSFHLIVEVRDSGG- 127
Cdd:cd11304    3 EVSVPENAPPGtVVLTVSATDP-DSGENGEVTYSIVSGNEDglFSIDPStGEITTAKPLDREE-QSSYTLTVTATDGGGp 80

                         90
                 ....*....|....*..
gi 667667684 128 -LKASTELQVNIVNLND 143
Cdd:cd11304   81 pLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 171-254 2.23e-11

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 60.44  E-value: 2.23e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684   171 TAEDPDDeGFPSHLLYSIT--TVSKYFMINQLTGTIQVAQRIDRDagelrQNPTISLEVLVKDRPYGGQENRIQITFIVE 248
Cdd:smart00112   1 SATDADS-GENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDRE-----EQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*.
gi 667667684   249 DVNDNP 254
Cdd:smart00112  75 DVNDNA 80
Cadherin pfam00028
Cadherin domain;
153-248 6.81e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.54  E-value: 6.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684  153 RVYTVLEELSPGTIVANITAEDPdDEGFPSHLLYSITT--VSKYFMINQLTGTIQVAQRIDRDagelrQNPTISLEVLVK 230
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDP-DLGPNGRIFYSILGggPGGNFRIDPDTGDISTTKPLDRE-----SIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 667667684  231 DRPYGGQENRIQITFIVE 248
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 70-146 3.84e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.20  E-value: 3.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684    70 AFDPeDTSRNIPLSYFLIS--PPKSFRMSAN-GTLFSTTELDFEAGHRsFHLIVEVRDSGG--LKASTELQVNIVNLNDE 144
Cdd:smart00112   2 ATDA-DSGENGKVTYSILSgnDDGLFSIDPEtGEITTTKPLDREEQPE-YTLTVEATDGGGppLSSTATVTITVLDVNDN 79


                   ..
gi 667667684   145 VP 146
Cdd:smart00112  80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 482-591 5.07e-08

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 51.16  E-value: 5.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684 482 SYFLALPVDLKVGTNIqnFKLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGsnvtRLLLTSRFDYaggfDKIWDYKL 560
Cdd:cd11304    1 SYEVSVPENAPPGTVV--LTVSATDPDSGENGeVTYSIVSGNEDGLFSIDPSTG----EITTAKPLDR----EEQSSYTL 70

                         90       100       110
                 ....*....|....*....|....*....|.
gi 667667684 561 LVYVTDDNLMSdrkkaealvETGTVTLSIKV 591
Cdd:cd11304   71 TVTATDGGGPP---------LSSTATVTITV 92
Cadherin pfam00028
Cadherin domain;
53-138 1.27e-07

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 49.99  E-value: 1.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684   53 HLYIVERANPG-FIYQVEAFDPeDTSRNIPLSYFLIS--PPKSFRM-SANGTLFSTTELDFEAGhRSFHLIVEVRDSGGL 128
Cdd:pfam00028   2 SASVPENAPVGtEVLTVTATDP-DLGPNGRIFYSILGggPGGNFRIdPDTGDISTTKPLDRESI-GEYELTVEATDSGGP 79

                          90
                  ....*....|
gi 667667684  129 KASTELQVNI 138
Cdd:pfam00028  80 PLSSTATVTI 89
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 152-231 9.63e-06

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 44.44  E-value: 9.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684  152 TRVYTVLEELSPGTIVANITAedpdDEGFPSHLLYS--ITTVSK----YFMINQLTGTIQVAQRIDRDagEL-RQNP--T 222
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAK----DLGLEVGELAArgARVVSKgnkqYFQLNPETGDLLLNEKLDRE--ELcGSTEpcV 74


                  ....*....
gi 667667684  223 ISLEVLVKD 231
Cdd:pfam08266  75 LHFQVLLEN 83
Cadherin pfam00028
Cadherin domain;
483-591 5.21e-04

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.59  E-value: 5.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667667684  483 YFLALPVDLKVGTNIQNfkLTCTDLDSSPRS-FRYSIGPGNVNNHFTFSPNAGSnvtrLLLTSRFDYaggfDKIWDYKLL 561
Cdd:pfam00028   1 YSASVPENAPVGTEVLT--VTATDPDLGPNGrIFYSILGGGPGGNFRIDPDTGD----ISTTKPLDR----ESIGEYELT 70

                          90       100       110
                  ....*....|....*....|....*....|
gi 667667684  562 VYVTDDNLMSDrkkaealveTGTVTLSIKV 591
Cdd:pfam00028  71 VEATDSGGPPL---------SSTATVTITV 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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