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Conserved domains on  [gi|667751613|ref|NP_001288111|]
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mevalonate kinase isoform b [Homo sapiens]

Protein Classification

PLN02677 superfamily protein( domain architecture ID 1907910)

PLN02677 superfamily protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLN02677 super family cl42972
mevalonate kinase
10-327 5.81e-74

mevalonate kinase


The actual alignment was detected with superfamily member PLN02677:

Pssm-ID: 215363 [Multi-domain]  Cd Length: 387  Bit Score: 233.57  E-value: 5.81e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613  10 APGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHS----NGKVDLSLPNIGIKRAWDVARLQSLdTSFLEQGDVTTPTS 85
Cdd:PLN02677   7 APGKIILAGEHAVVHGSTAVAAAIDLYTYVSLRFPPsaenDDTLKLQLKDLGLEFSWPLARIKEA-LPDLGTPCPSTPTS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613  86 EQVEKLKEVAGLPDDCAVTE-----RLAVLAFLYLYLSI--------------------------C-------------- 120
Cdd:PLN02677  86 CSEETLKSIAALVEEQNIPEakiwlSSGVSAFLWLYTSIlgfnpatvvvtselplgsglgssaafCvalsaallaasdsi 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613 121 ----RKQRWT---KEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRA 193
Cdd:PLN02677 166 svstGGNGWSsldETDLELVNKWAFEGEKIIHGKPSGIDNTVSTYGNMIKFKSGELTRLQSNMPLKMLITNTRVGRNTKA 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613 194 LVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLgemgEAPAPEQYLV------LEELIDMNQHHLNALGVGHASLDQLC 267
Cdd:PLN02677 246 LVAGVSERALRHPDAMKSVFNAVDSISEELATII----QSPAEDELSItekeekLKELMEMNQGLLQCMGVSHSSIETVL 321
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613 268 QVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSI 327
Cdd:PLN02677 322 RTTLKYKLVSKLTGAGGGGCVLTLLPTLLSGTVVDKVIAELESSGFQCFTAGIGGNGVQI 381
 
Name Accession Description Interval E-value
PLN02677 PLN02677
mevalonate kinase
10-327 5.81e-74

mevalonate kinase


Pssm-ID: 215363 [Multi-domain]  Cd Length: 387  Bit Score: 233.57  E-value: 5.81e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613  10 APGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHS----NGKVDLSLPNIGIKRAWDVARLQSLdTSFLEQGDVTTPTS 85
Cdd:PLN02677   7 APGKIILAGEHAVVHGSTAVAAAIDLYTYVSLRFPPsaenDDTLKLQLKDLGLEFSWPLARIKEA-LPDLGTPCPSTPTS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613  86 EQVEKLKEVAGLPDDCAVTE-----RLAVLAFLYLYLSI--------------------------C-------------- 120
Cdd:PLN02677  86 CSEETLKSIAALVEEQNIPEakiwlSSGVSAFLWLYTSIlgfnpatvvvtselplgsglgssaafCvalsaallaasdsi 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613 121 ----RKQRWT---KEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRA 193
Cdd:PLN02677 166 svstGGNGWSsldETDLELVNKWAFEGEKIIHGKPSGIDNTVSTYGNMIKFKSGELTRLQSNMPLKMLITNTRVGRNTKA 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613 194 LVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLgemgEAPAPEQYLV------LEELIDMNQHHLNALGVGHASLDQLC 267
Cdd:PLN02677 246 LVAGVSERALRHPDAMKSVFNAVDSISEELATII----QSPAEDELSItekeekLKELMEMNQGLLQCMGVSHSSIETVL 321
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613 268 QVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSI 327
Cdd:PLN02677 322 RTTLKYKLVSKLTGAGGGGCVLTLLPTLLSGTVVDKVIAELESSGFQCFTAGIGGNGVQI 381
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
10-280 4.17e-46

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 157.84  E-value: 4.17e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613   10 APGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG-KVDLSLPNIGIKRAWD-VARLQSLDTSFLEQGDVTTPTSEQ 87
Cdd:TIGR00549   1 APGKIILFGEHAVVYGEPAIAAPIPLRTTVTVIESSDGsFIESDLGRGSLDDAPDeLDGLKYVLAEFLSRFSELNPPPLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613   88 VEKLKEV---AGLPDDCAVTerLAVLAFLYLYLSIcrkqrwtKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRY 164
Cdd:TIGR00549  81 ITIESEIppgRGLGSSAAVA--VALIRALADYFGS-------ELSKEELAELANEAEKIAHGKPSGIDTATSTSGGPVYF 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613  165 HQGK-ISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLgEMGEAPApeqylvLE 243
Cdd:TIGR00549 152 EKGEgEFTKLISLDGYFVIADTGVSGSTKEAVARVRQLLERFPELIDSIMDAIGELTLEAKAAL-QDGDVES------LG 224
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 667751613  244 ELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLT 280
Cdd:TIGR00549 225 ELMNINQGLLKALGVSHPKLDQLVEIARKAGaLGAKLT 262
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
10-280 3.08e-42

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 148.07  E-value: 3.08e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613  10 APGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIkrAWDVARLQSLDTSFLEQGdvttptseqVE 89
Cdd:COG1577    1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKLRIESPDLGG--TLDLDPLADAALRYIKAA---------IE 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613  90 KLKEVAGLPDDC-------------------AVTerLAVLAFLYLYLSIcrkqrwtKEDLELINKWAFQGERMIHGNPSG 150
Cdd:COG1577   70 AALEYLGLPLKGfdieidseiprkrglgssaAVA--VAVIRALAAFYGV-------ELSKEELFKLALEAEKIVHGNPSG 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613 151 VDNAVSTWGGALRYHQGK-ISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLgE 229
Cdd:COG1577  141 LDTAASTYGGPIYYQRGDrAEPLELPKNLPLVVGDTGVPASTKELVAKVRKLKERNPELYEAFLEEIGDLVEEAIEAL-E 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 667751613 230 MGEAPApeqylvLEELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLT 280
Cdd:COG1577  220 EGDLEA------LGELMNENHGLLRALGVSTPELDRLVEAARKAGaLGAKLT 265
 
Name Accession Description Interval E-value
PLN02677 PLN02677
mevalonate kinase
10-327 5.81e-74

mevalonate kinase


Pssm-ID: 215363 [Multi-domain]  Cd Length: 387  Bit Score: 233.57  E-value: 5.81e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613  10 APGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHS----NGKVDLSLPNIGIKRAWDVARLQSLdTSFLEQGDVTTPTS 85
Cdd:PLN02677   7 APGKIILAGEHAVVHGSTAVAAAIDLYTYVSLRFPPsaenDDTLKLQLKDLGLEFSWPLARIKEA-LPDLGTPCPSTPTS 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613  86 EQVEKLKEVAGLPDDCAVTE-----RLAVLAFLYLYLSI--------------------------C-------------- 120
Cdd:PLN02677  86 CSEETLKSIAALVEEQNIPEakiwlSSGVSAFLWLYTSIlgfnpatvvvtselplgsglgssaafCvalsaallaasdsi 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613 121 ----RKQRWT---KEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRA 193
Cdd:PLN02677 166 svstGGNGWSsldETDLELVNKWAFEGEKIIHGKPSGIDNTVSTYGNMIKFKSGELTRLQSNMPLKMLITNTRVGRNTKA 245
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613 194 LVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLgemgEAPAPEQYLV------LEELIDMNQHHLNALGVGHASLDQLC 267
Cdd:PLN02677 246 LVAGVSERALRHPDAMKSVFNAVDSISEELATII----QSPAEDELSItekeekLKELMEMNQGLLQCMGVSHSSIETVL 321
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613 268 QVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSI 327
Cdd:PLN02677 322 RTTLKYKLVSKLTGAGGGGCVLTLLPTLLSGTVVDKVIAELESSGFQCFTAGIGGNGVQI 381
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
10-280 4.17e-46

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 157.84  E-value: 4.17e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613   10 APGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNG-KVDLSLPNIGIKRAWD-VARLQSLDTSFLEQGDVTTPTSEQ 87
Cdd:TIGR00549   1 APGKIILFGEHAVVYGEPAIAAPIPLRTTVTVIESSDGsFIESDLGRGSLDDAPDeLDGLKYVLAEFLSRFSELNPPPLE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613   88 VEKLKEV---AGLPDDCAVTerLAVLAFLYLYLSIcrkqrwtKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRY 164
Cdd:TIGR00549  81 ITIESEIppgRGLGSSAAVA--VALIRALADYFGS-------ELSKEELAELANEAEKIAHGKPSGIDTATSTSGGPVYF 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613  165 HQGK-ISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLgEMGEAPApeqylvLE 243
Cdd:TIGR00549 152 EKGEgEFTKLISLDGYFVIADTGVSGSTKEAVARVRQLLERFPELIDSIMDAIGELTLEAKAAL-QDGDVES------LG 224
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 667751613  244 ELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLT 280
Cdd:TIGR00549 225 ELMNINQGLLKALGVSHPKLDQLVEIARKAGaLGAKLT 262
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
10-280 3.08e-42

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 148.07  E-value: 3.08e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613  10 APGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIkrAWDVARLQSLDTSFLEQGdvttptseqVE 89
Cdd:COG1577    1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKLRIESPDLGG--TLDLDPLADAALRYIKAA---------IE 69
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613  90 KLKEVAGLPDDC-------------------AVTerLAVLAFLYLYLSIcrkqrwtKEDLELINKWAFQGERMIHGNPSG 150
Cdd:COG1577   70 AALEYLGLPLKGfdieidseiprkrglgssaAVA--VAVIRALAAFYGV-------ELSKEELFKLALEAEKIVHGNPSG 140
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613 151 VDNAVSTWGGALRYHQGK-ISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLgE 229
Cdd:COG1577  141 LDTAASTYGGPIYYQRGDrAEPLELPKNLPLVVGDTGVPASTKELVAKVRKLKERNPELYEAFLEEIGDLVEEAIEAL-E 219
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 667751613 230 MGEAPApeqylvLEELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLT 280
Cdd:COG1577  220 EGDLEA------LGELMNENHGLLRALGVSTPELDRLVEAARKAGaLGAKLT 265
PRK03926 PRK03926
mevalonate kinase; Provisional
7-327 3.96e-34

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 127.09  E-value: 3.96e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613   7 LVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGkvdlslpnIGIkrawdvarlqslDTSFLEQGDVTTPTSE 86
Cdd:PRK03926   3 LCSAPGKIYLFGEHAVVYGKPAIACAIDLRTYVRAEFNDDS--------IYI------------ESDYGKTGEKHPYVSA 62
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613  87 QVEKLKEVA-----------------GLPDDCAVTERL--AVLAFLYLYLSicrkqrwtkedLELINKWAFQGERMIHGN 147
Cdd:PRK03926  63 AIEKMREEAdkdgvtvsitsqipvgsGLGSSAAVTVATigALNRLLGLGLS-----------LEEIAKLGHKVELLVQGA 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613 148 PSGVDNAVSTWGGALRYHQGKisSLKrSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVL 227
Cdd:PRK03926 132 ASPTDTYVSTMGGFVTIPDRK--KLP-FPECGIVVGYTGSSGSTKELVANVRKLKEEYPELIEPILSSIGKISEKGEELI 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613 228 gemgeapAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLTGAGGGGCGITLLKPGlEQPEVeATkq 306
Cdd:PRK03926 209 -------LSGDYVSLGELMNINQGLLDALGVSTKELSELIYAARTAGaLGAKITGAGGGGCMVALAAPE-KQSEV-AT-- 277
                        330       340
                 ....*....|....*....|.
gi 667751613 307 ALTSCGFDCLETSIGAPGVSI 327
Cdd:PRK03926 278 AIKIAGGKPIITKITDEGLRI 298
PTZ00298 PTZ00298
mevalonate kinase; Provisional
12-280 3.71e-10

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 60.25  E-value: 3.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613  12 GKVILHGEHAVVHGKVALAVSLNLRTFLRLQ--PHSNG-KVDLSLPNIG--IKRAWD--------VARLQSLDTS----F 74
Cdd:PTZ00298  17 GKVILFGEHFVVYGAEAIVAGIDEYTECRLEltKGVPGlQVVDQRPAVPgyIVEKREeqrkahqlVLRHLNIDTSvdglK 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613  75 LEQGDVTTPTSeqveklKEVAGLPDDCAVTERLAVLAFLYLylsicrkqrwTKEDlelINKWAFQGERMIHGNPSGVDNA 154
Cdd:PTZ00298  97 MHLGGPLVPSS------GIGASASDVVSLSRALSELYQLNL----------TEEE---VNLSAFVGEGGYHGTPSGADNT 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667751613 155 VSTWGGALRY--HQGK--ISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAIslecervLGEM 230
Cdd:PTZ00298 158 AATYGGLISYrrVNGKsvFKRIAFQQPLYLVVCSTGITASTTKVVGDVRKLKENQPTWFNRLLENYNAC-------VSEA 230
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 667751613 231 GEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARG-LHSKLT 280
Cdd:PTZ00298 231 KEALQKGNLFRVGELMNANHDLCQKLTVSCRELDSIVQTCRTYGaLGAKMS 281
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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