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Conserved domains on  [gi|685424573|ref|NP_001288748|]
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zinc finger protein 202 isoform 2 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-73 7.98e-25

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 96.51  E-value: 7.98e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 685424573    13 VTFKDVAVCFSQDQWSDLDPTQKEFYGEYVLeEDCGIVVSLSFPIPRPDEISQV-REEEPWV 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVML-ENYSNLVSLGFQVPKPDLISQLeQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
367-424 5.73e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 5.73e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 685424573 367 RPCRCNECGKSFSRRDHLVRHQRTHTGEKPFTC--PTCGKSFSRGYHLIRHQRTHSEKTS 424
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
136-298 2.44e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 2.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685424573 136 DNPGRLNERRFGTNISQVNSFVNLRETTPvhpllgrhHDCSVCGKSFTCNSHLVRHLRT--HTGE--KPYKCME--CGKS 209
Cdd:COG5048  261 PRSSLPTASSQSSSPNESDSSSEKGFSLP--------IKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKL 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685424573 210 YTRSSHLARHQKVHKMNAPYKYPLNRKNLEETSPVTQAERTPSVEKP--------------------------------- 256
Cdd:COG5048  333 FSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKdlkndkksetlsnscirnfkrdsnlslhiithl 412

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 685424573 257 ------YRCDDCGKHFRWTSDLVRHQRTHTGEKPFFCTICGKSFSQKS 298
Cdd:COG5048  413 sfrpynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-73 7.98e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 96.51  E-value: 7.98e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 685424573    13 VTFKDVAVCFSQDQWSDLDPTQKEFYGEYVLeEDCGIVVSLSFPIPRPDEISQV-REEEPWV 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVML-ENYSNLVSLGFQVPKPDLISQLeQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-53 7.52e-13

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 62.49  E-value: 7.52e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 685424573   12 LVTFKDVAVCFSQDQWSDLDPTQKEFYGEyVLEEDCGIVVSL 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRD-VMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-53 9.35e-13

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 62.18  E-value: 9.35e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 685424573  13 VTFKDVAVCFSQDQWSDLDPTQKEFYGEYVLEEdCGIVVSL 53
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLEN-YENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
367-424 5.73e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 5.73e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 685424573 367 RPCRCNECGKSFSRRDHLVRHQRTHTGEKPFTC--PTCGKSFSRGYHLIRHQRTHSEKTS 424
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
136-298 2.44e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 2.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685424573 136 DNPGRLNERRFGTNISQVNSFVNLRETTPvhpllgrhHDCSVCGKSFTCNSHLVRHLRT--HTGE--KPYKCME--CGKS 209
Cdd:COG5048  261 PRSSLPTASSQSSSPNESDSSSEKGFSLP--------IKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKL 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685424573 210 YTRSSHLARHQKVHKMNAPYKYPLNRKNLEETSPVTQAERTPSVEKP--------------------------------- 256
Cdd:COG5048  333 FSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKdlkndkksetlsnscirnfkrdsnlslhiithl 412

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 685424573 257 ------YRCDDCGKHFRWTSDLVRHQRTHTGEKPFFCTICGKSFSQKS 298
Cdd:COG5048  413 sfrpynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-408 8.97e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 8.97e-06
                          10        20
                  ....*....|....*....|....*.
gi 685424573  383 HLVRHQRTHTGEKPFTCPTCGKSFSR 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
187-212 1.37e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.37e-05
                          10        20
                  ....*....|....*....|....*.
gi 685424573  187 HLVRHLRTHTGEKPYKCMECGKSYTR 212
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-73 7.98e-25

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 96.51  E-value: 7.98e-25
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 685424573    13 VTFKDVAVCFSQDQWSDLDPTQKEFYGEYVLeEDCGIVVSLSFPIPRPDEISQV-REEEPWV 73
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVML-ENYSNLVSLGFQVPKPDLISQLeQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 12-53 7.52e-13

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 62.49  E-value: 7.52e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 685424573   12 LVTFKDVAVCFSQDQWSDLDPTQKEFYGEyVLEEDCGIVVSL 53
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRD-VMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-53 9.35e-13

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 62.18  E-value: 9.35e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 685424573  13 VTFKDVAVCFSQDQWSDLDPTQKEFYGEYVLEEdCGIVVSL 53
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLEN-YENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
367-424 5.73e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 5.73e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 685424573 367 RPCRCNECGKSFSRRDHLVRHQRTHTGEKPFTC--PTCGKSFSRGYHLIRHQRTHSEKTS 424
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
208-408 5.54e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 5.54e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685424573 208 KSYTRSSHLARHQKVHKMNAPYKYPLNRKNLEETSPvTQAERTPSVEK----PYRCDDCGKHFRWTSDLVRHQRT--HTG 281
Cdd:COG5048  238 KSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSS-SPNESDSSSEKgfslPIKSKQCNISFSRSSPLTRHLRSvnHSG 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685424573 282 E--KPFFCTI--CGKSFSQKSVLTTHQRIHLGGKPYLC--GECGEDFS-----EHRRYLAHRKTHAAEELYLC--SECGR 348
Cdd:COG5048  317 EslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIR 396

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 685424573 349 CFTHSAAFAKHLRGHASVRP--CRCNECGKSFSRRDHLVRHQRTHTGEKPFTCPTCGKSFSR 408
Cdd:COG5048  397 NFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
173-420 6.11e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 6.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685424573 173 HDCSVCGKSFTCNSHLVRHLRTHTGEKPYKCM--ECGKSYTRSSHLARHQKVHKMN----------------APYKYPL- 233
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNpsdlnskslplsnskaSSSSLSSs 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685424573 234 ----NRKNLEETSPVTQAERTPSVEKPYRCDD-------------------------------CGKHFRWTSDLVrHQRT 278
Cdd:COG5048  114 ssnsNDNNLLSSHSLPPSSRDPQLPDLLSISNlrnnplpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLI-SSNV 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685424573 279 HTGEKPFFCTICGKSFSQKSVLTTHQRIHLGGKPYLCGECGedFSEHRRYLAHRKTHAAEElYLCSECGRCFTHSAAFAK 358
Cdd:COG5048  193 STSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSS-DSSSSASESPRSSLPTAS 269

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 685424573 359 HLRGH----------ASVRPCRCNECGKSFSRRDHLVRHQRT--HTGE--KPFTCP--TCGKSFSRGYHLIRHQRTHS 420
Cdd:COG5048  270 SQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHT 347
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
136-298 2.44e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 2.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685424573 136 DNPGRLNERRFGTNISQVNSFVNLRETTPvhpllgrhHDCSVCGKSFTCNSHLVRHLRT--HTGE--KPYKCME--CGKS 209
Cdd:COG5048  261 PRSSLPTASSQSSSPNESDSSSEKGFSLP--------IKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKL 332

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685424573 210 YTRSSHLARHQKVHKMNAPYKYPLNRKNLEETSPVTQAERTPSVEKP--------------------------------- 256
Cdd:COG5048  333 FSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKdlkndkksetlsnscirnfkrdsnlslhiithl 412

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 685424573 257 ------YRCDDCGKHFRWTSDLVRHQRTHTGEKPFFCTICGKSFSQKS 298
Cdd:COG5048  413 sfrpynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
383-408 8.97e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 8.97e-06
                          10        20
                  ....*....|....*....|....*.
gi 685424573  383 HLVRHQRTHTGEKPFTCPTCGKSFSR 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
187-212 1.37e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.37e-05
                          10        20
                  ....*....|....*....|....*.
gi 685424573  187 HLVRHLRTHTGEKPYKCMECGKSYTR 212
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
271-296 1.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.09e-04
                          10        20
                  ....*....|....*....|....*.
gi 685424573  271 DLVRHQRTHTGEKPFFCTICGKSFSQ 296
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
255-315 2.51e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.51e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 685424573 255 KPYRCDDCGKHFRWTSDLVRHQRTHTGEKPFFCT--ICGKSFSQKSVLTTHQRIHLGGKPYLC 315
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLN 94
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 369-391 3.31e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.66  E-value: 3.31e-04
                          10        20
                  ....*....|....*....|...
gi 685424573  369 CRCNECGKSFSRRDHLVRHQRTH 391
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 197-280 3.76e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 3.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 685424573 197 GEKPYKC--MECGKSYTRSSHLarhqKVHKMNAPYKYPLNRKNLEETSPVTQAErtpsvEKPYRCDDCGKHFRWTSDLVR 274
Cdd:COG5189  346 DGKPYKCpvEGCNKKYKNQNGL----KYHMLHGHQNQKLHENPSPEKMNIFSAK-----DKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 685424573 275 HqRTHT 280
Cdd:COG5189  417 H-RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 397-419 5.56e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 5.56e-04
                          10        20
                  ....*....|....*....|...
gi 685424573  397 FTCPTCGKSFSRGYHLIRHQRTH 419
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 201-223 9.16e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.51  E-value: 9.16e-04
                          10        20
                  ....*....|....*....|...
gi 685424573  201 YKCMECGKSYTRSSHLARHQKVH 223
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 285-307 3.91e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 3.91e-03
                          10        20
                  ....*....|....*....|...
gi 685424573  285 FFCTICGKSFSQKSVLTTHQRIH 307
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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