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Conserved domains on  [gi|720642346|ref|NP_001289706|]
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valacyclovir hydrolase isoform 2 [Homo sapiens]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 23-274 7.63e-48

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 158.63  E-value: 7.63e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346  23 TSAKVAVNGVQLHYQQTGEGDHAVLLLPGMLGSGETdFGPQLKNLNKKlFTVVAWDPRGYGHSRPPDRDFPadfFERDAK 102
Cdd:COG0596    3 TPRFVTVDGVRLHYREAGPDGPPVVLLHGLPGSSYE-WRPLIPALAAG-YRVIAPDLRGHGRSDKPAGGYT---LDDLAD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346 103 DAVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIwganayVTDEDSMIYEGIRDVSKWSERTRKPLEALYGY 182
Cdd:COG0596   78 DLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVL------VDEVLAALAEPLRRPGLAPEALAALLRALART 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346 183 DYfartcekwvdgirqfkhlpdgnicRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGSRLHLMPEGKHNLHLRFA 262
Cdd:COG0596  152 DL------------------------RERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPGAGHFPPLEQP 207

                        250
                 ....*....|..
gi 720642346 263 DEFNKLAEDFLQ 274
Cdd:COG0596  208 EAFAAALRDFLA 219
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 23-274 7.63e-48

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 158.63  E-value: 7.63e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346  23 TSAKVAVNGVQLHYQQTGEGDHAVLLLPGMLGSGETdFGPQLKNLNKKlFTVVAWDPRGYGHSRPPDRDFPadfFERDAK 102
Cdd:COG0596    3 TPRFVTVDGVRLHYREAGPDGPPVVLLHGLPGSSYE-WRPLIPALAAG-YRVIAPDLRGHGRSDKPAGGYT---LDDLAD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346 103 DAVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIwganayVTDEDSMIYEGIRDVSKWSERTRKPLEALYGY 182
Cdd:COG0596   78 DLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVL------VDEVLAALAEPLRRPGLAPEALAALLRALART 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346 183 DYfartcekwvdgirqfkhlpdgnicRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGSRLHLMPEGKHNLHLRFA 262
Cdd:COG0596  152 DL------------------------RERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPGAGHFPPLEQP 207

                        250
                 ....*....|..
gi 720642346 263 DEFNKLAEDFLQ 274
Cdd:COG0596  208 EAFAAALRDFLA 219
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 45-259 1.08e-24

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 98.73  E-value: 1.08e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346   45 AVLLLPGMLGSGEtDFGPQLKNLNKKLFTVVAWDPRGYGHSRPP--DRDFPADFFerdAKDAVDLMKALKFKKVSLLGWS 122
Cdd:pfam00561   2 PVLLLHGLPGSSD-LWRKLAPALARDGFRVIALDLRGFGKSSRPkaQDDYRTDDL---AEDLEYILEALGLEKVNLVGHS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346  123 DGGITALIAAAKYPSYIHKMVIWGANAYVTDEDSMIYEGIRDVSKWSERTR--------KPLEALYGYDYFARTCEK--- 191
Cdd:pfam00561  78 MGGLIALAYAAKYPDRVKALVLLGALDPPHELDEADRFILALFPGFFDGFVadfapnplGRLVAKLLALLLLRLRLLkal 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346  192 -------WVDGIRQFKHLPDGNI----------CRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGSRLHLMPEGK 254
Cdd:pfam00561 158 pllnkrfPSGDYALAKSLVTGALlfietwstelRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIPDAG 237


                  ....*
gi 720642346  255 HNLHL 259
Cdd:pfam00561 238 HFAFL 242
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 23-274 7.63e-48

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 158.63  E-value: 7.63e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346  23 TSAKVAVNGVQLHYQQTGEGDHAVLLLPGMLGSGETdFGPQLKNLNKKlFTVVAWDPRGYGHSRPPDRDFPadfFERDAK 102
Cdd:COG0596    3 TPRFVTVDGVRLHYREAGPDGPPVVLLHGLPGSSYE-WRPLIPALAAG-YRVIAPDLRGHGRSDKPAGGYT---LDDLAD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346 103 DAVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIwganayVTDEDSMIYEGIRDVSKWSERTRKPLEALYGY 182
Cdd:COG0596   78 DLAALLDALGLERVVLVGHSMGGMVALELAARHPERVAGLVL------VDEVLAALAEPLRRPGLAPEALAALLRALART 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346 183 DYfartcekwvdgirqfkhlpdgnicRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGSRLHLMPEGKHNLHLRFA 262
Cdd:COG0596  152 DL------------------------RERLARITVPTLVIWGEKDPIVPPALARRLAELLPNAELVVLPGAGHFPPLEQP 207

                        250
                 ....*....|..
gi 720642346 263 DEFNKLAEDFLQ 274
Cdd:COG0596  208 EAFAAALRDFLA 219
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
42-274 4.47e-26

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 102.71  E-value: 4.47e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346  42 GDHAVLLLPGmLGSGETDFGPQLKNLNKKLFTVVAwdPRGYGHSRPPDrDF----PADFFErDAKDAVDLMKAlKFKKVS 117
Cdd:COG1647   14 GRKGVLLLHG-FTGSPAEMRPLAEALAKAGYTVYA--PRLPGHGTSPE-DLlkttWEDWLE-DVEEAYEILKA-GYDKVI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346 118 LLGWSDGGITALIAAAKYPSyIHKMVIWGANAYVTDEDS----MIYEGIRDVSKWSERTRKPLEALYGYDYFartcekWV 193
Cdd:COG1647   88 VIGLSMGGLLALLLAARYPD-VAGLVLLSPALKIDDPSApllpLLKYLARSLRGIGSDIEDPEVAEYAYDRT------PL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346 194 DGIRQFKHLpdGNICRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGS--RLHLMPEGKHNLHL-RFADEFNKLAE 270
Cdd:COG1647  161 RALAELQRL--IREVRRDLPKITAPTLIIQSRKDEVVPPESARYIYERLGSPdkELVWLEDSGHVITLdKDREEVAEEIL 238


                 ....
gi 720642346 271 DFLQ 274
Cdd:COG1647  239 DFLE 242
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 45-259 1.08e-24

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 98.73  E-value: 1.08e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346   45 AVLLLPGMLGSGEtDFGPQLKNLNKKLFTVVAWDPRGYGHSRPP--DRDFPADFFerdAKDAVDLMKALKFKKVSLLGWS 122
Cdd:pfam00561   2 PVLLLHGLPGSSD-LWRKLAPALARDGFRVIALDLRGFGKSSRPkaQDDYRTDDL---AEDLEYILEALGLEKVNLVGHS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346  123 DGGITALIAAAKYPSYIHKMVIWGANAYVTDEDSMIYEGIRDVSKWSERTR--------KPLEALYGYDYFARTCEK--- 191
Cdd:pfam00561  78 MGGLIALAYAAKYPDRVKALVLLGALDPPHELDEADRFILALFPGFFDGFVadfapnplGRLVAKLLALLLLRLRLLkal 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346  192 -------WVDGIRQFKHLPDGNI----------CRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGSRLHLMPEGK 254
Cdd:pfam00561 158 pllnkrfPSGDYALAKSLVTGALlfietwstelRAKFLGRLDEPTLIIWGDQDPLVPPQALEKLAQLFPNARLVVIPDAG 237


                  ....*
gi 720642346  255 HNLHL 259
Cdd:pfam00561 238 HFAFL 242
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
28-274 4.61e-22

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 91.22  E-value: 4.61e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346  28 AVNGVQLHYQQ---TGEGDHAVLLLPGMLGSGETdFGPQLKNLNKKLFTVVAWDPRGYGHSRPPDRDFP-ADFFERDAKD 103
Cdd:COG2267   10 TRDGLRLRGRRwrpAGSPRGTVVLVHGLGEHSGR-YAELAEALAAAGYAVLAFDLRGHGRSDGPRGHVDsFDDYVDDLRA 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346 104 AVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIWGAnAYVTDEDSMIYEGirdvskwsertrkplealygyd 183
Cdd:COG2267   89 ALDALRARPGLPVVLLGHSMGGLIALLYAARYPDRVAGLVLLAP-AYRADPLLGPSAR---------------------- 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346 184 yfartcekWVDGIRQFKHlpdgnicrhlLPRVQCPALIVHGEKDPLVPRFHA-DFIHKHVKGSRLHLMPEGKHNLHL-RF 261
Cdd:COG2267  146 --------WLRALRLAEA----------LARIDVPVLVLHGGADRVVPPEAArRLAARLSPDVELVLLPGARHELLNePA 207

                        250
                 ....*....|...
gi 720642346 262 ADEFNKLAEDFLQ 274
Cdd:COG2267  208 REEVLAAILAWLE 220
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
45-273 2.57e-18

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 81.60  E-value: 2.57e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346  45 AVLLLPGMLGSGETDFGPQLKNLNKKLFTVVAWDPRGYGHSRppdRDFPADFFErDAKDAVDLMKALKF---KKVSLLGW 121
Cdd:COG1506   25 VVVYVHGGPGSRDDSFLPLAQALASRGYAVLAPDYRGYGESA---GDWGGDEVD-DVLAAIDYLAARPYvdpDRIGIYGH 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346 122 SDGGITALIAAAKYPSYIHKMVIWGAnayVTDEDSMiYEGIRDVSKWSERTrkPLEALYGYDyfARTCEKWVDgirqfkh 201
Cdd:COG1506  101 SYGGYMALLAAARHPDRFKAAVALAG---VSDLRSY-YGTTREYTERLMGG--PWEDPEAYA--ARSPLAYAD------- 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 720642346 202 lpdgnicrhllpRVQCPALIVHGEKDPLVP-----RFHADFIHKHVKgSRLHLMPEGKHNLHLRFADEFNKLAEDFL 273
Cdd:COG1506  166 ------------KLKTPLLLIHGEADDRVPpeqaeRLYEALKKAGKP-VELLVYPGEGHGFSGAGAPDYLERILDFL 229
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 72-274 2.59e-14

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 70.71  E-value: 2.59e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346  72 FTVVAWDPRGYGHS--RPPDRDFPAdffERDAKDAVDLMKALKF---KKVSLLGWSDGGITALIAAAKYPsyihkmviwG 146
Cdd:COG1073   65 FNVLAFDYRGYGESegEPREEGSPE---RRDARAAVDYLRTLPGvdpERIGLLGISLGGGYALNAAATDP---------R 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346 147 ANAYVTDedSMIYEgIRDVSKwsERTRKPLEALYGYDYFaRTCEKWVDGIR-QFKHLpdgnicrHLLPRVQCPALIVHGE 225
Cdd:COG1073  133 VKAVILD--SPFTS-LEDLAA--QRAKEARGAYLPGVPY-LPNVRLASLLNdEFDPL-------AKIEKISRPLLFIHGE 199

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 720642346 226 KDPLVPRFHADFIHKHVKGS-RLHLMPEGKHN-LHLRFADEFNKLAEDFLQ 274
Cdd:COG1073  200 KDEAVPFYMSEDLYEAAAEPkELLIVPGAGHVdLYDRPEEEYFDKLAEFFK 250
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 46-268 2.88e-11

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 61.34  E-value: 2.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346   46 VLLLPGMlgsgeTDFGPQLKNLNKKLFTVVAWDPRGYGHSRPPDRDFPadfferDAKDAVDLMKALK-FKKVSLLGWSDG 124
Cdd:pfam12697   1 VVLVHGA-----GLSAAPLAALLAAGVAVLAPDLPGHGSSSPPPLDLA------DLADLAALLDELGaARPVVLVGHSLG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346  125 GITALIAAAkypSYIHKMVIWGANAYVTDEDSMIYEGIRDVSKWSERTRKPLEALYGYDYFARTC--EKWVDGIRQFKHL 202
Cdd:pfam12697  70 GAVALAAAA---AALVVGVLVAPLAAPPGLLAALLALLARLGAALAAPAWLAAESLARGFLDDLPadAEWAAALARLAAL 146

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 720642346  203 PDGN--ICRHLLPRVQCPALIVHGEkDPLVPRFHADFIHKhVKGSRLHLMPEGKHNLHLRfADEFNKL 268
Cdd:pfam12697 147 LAALalLPLAAWRDLPVPVLVLAEE-DRLVPELAQRLLAA-LAGARLVVLPGAGHLPLDD-PEEVAEA 211
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 45-258 3.41e-09

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 55.68  E-value: 3.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346   45 AVLLLPGMlgsGET-----DFGpqlKNLNKKLFTVVAWDPRGYGHSRPPDRDFPA-DFFERDAKDAVDLMKAL-KFKKVS 117
Cdd:pfam12146   6 VVVLVHGL---GEHsgryaHLA---DALAAQGFAVYAYDHRGHGRSDGKRGHVPSfDDYVDDLDTFVDKIREEhPGLPLF 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346  118 LLGWSDGGITALIAAAKYPSYIHKMVIWGAnAYVTDEDSM-----------------IYEGIRDVSKWSERTRKPLEAlY 180
Cdd:pfam12146  80 LLGHSMGGLIAALYALRYPDKVDGLILSAP-ALKIKPYLAppilkllakllgklfprLRVPNNLLPDSLSRDPEVVAA-Y 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346  181 GYDyfartceKWVDG---IRQFKHLPD-GNICRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGS--RLHLMPEGK 254
Cdd:pfam12146 158 AAD-------PLVHGgisARTLYELLDaGERLLRRAAAITVPLLLLHGGADRVVDPAGSREFYERAGSTdkTLKLYPGLY 230


                  ....
gi 720642346  255 HNLH 258
Cdd:pfam12146 231 HELL 234
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
45-269 3.21e-05

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 44.19  E-value: 3.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346  45 AVLLLPGMLGSGET--DFGPQLKNLNkklFTVVAWDPRGYGHSRPPDRD-------FPADFFERDAKDAVDLMKALKF-- 113
Cdd:COG0412   31 GVVVLHEIFGLNPHirDVARRLAAAG---YVVLAPDLYGRGGPGDDPDEaralmgaLDPELLAADLRAALDWLKAQPEvd 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346 114 -KKVSLLGWSDGGITALIAAAKYPsyihkmviwGANAYVtdedsmiyegirdvskwsertrkpleALYGydyfartcekw 192
Cdd:COG0412  108 aGRVGVVGFCFGGGLALLAAARGP---------DLAAAV--------------------------SFYG----------- 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346 193 vdgirqfkhLPDGNICRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGS----RLHLMPEGKHNLHLRFADEFNKL 268
Cdd:COG0412  142 ---------GLPADDLLDLAARIKAPVLLLYGEKDPLVPPEQVAALEAALAAAgvdvELHVYPGAGHGFTNPGRPRYDPA 212


                 .
gi 720642346 269 A 269
Cdd:COG0412  213 A 213
YpfH COG0400
Predicted esterase [General function prediction only];
39-147 4.86e-04

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 40.28  E-value: 4.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346  39 TGEGDHAVLLLPGmLGSGETDFGPQLKNLNKKLFTVVAwdPRG-----YGHSRPPDRDFPADFF-ERDAKDAVDLMKA-- 110
Cdd:COG0400    1 GGPAAPLVVLLHG-YGGDEEDLLPLAPELALPGAAVLA--PRApvpegPGGRAWFDLSFLEGREdEEGLAAAAEALAAfi 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 720642346 111 --------LKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIWGA 147
Cdd:COG0400   78 delearygIDPERIVLAGFSQGAAMALSLALRRPELLAGVVALSG 122
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 44-143 8.05e-03

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 35.19  E-value: 8.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 720642346  44 HAVLLLPGMLGSGETdFGPQLKNLNKKLFTVVAWDprgYGhSRPPDRDFPADFFerdaKDAVD-LMKALKFKKVSLLGWS 122
Cdd:COG1075    6 YPVVLVHGLGGSAAS-WAPLAPRLRAAGYPVYALN---YP-STNGSIEDSAEQL----AAFVDaVLAATGAEKVDLVGHS 76

                         90       100
                 ....*....|....*....|...
gi 720642346 123 DGGITALIAAAKY--PSYIHKMV 143
Cdd:COG1075   77 MGGLVARYYLKRLggAAKVARVV 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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