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Conserved domains on  [gi|733606575|ref|NP_001290042|]
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DENN domain-containing protein 10 isoform 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPA super family cl40631
Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque ...
 9-113 1.09e-08

Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarization-specific docking factor.


The actual alignment was detected with superfamily member pfam08616:

Pssm-ID: 454797  Cd Length: 113  Bit Score: 51.14  E-value: 1.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606575    9 VDIVSQFGMETVILHTALMLKKRIVV--YHPKIEAVQEFTRTLPALVWH----RQDWTILHSYVHLNadELEALQMCTGY 82
Cdd:pfam08616   5 LKLLGPFTPPIILLINALLTSKRIIFlsYQRSAGEVSEFVLALCNLISGgfvlRGFTNNSFPYVDLS--KLDALRKVPGY 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 733606575   83 VAGfvdleVSN-----RPDLYDVFVNLAESEITIAP 113
Cdd:pfam08616  83 IAG-----VTNpifenQDQWWDVLCDLDSGSVKLSK 113
 
Name Accession Description Interval E-value
SPA pfam08616
Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque ...
 9-113 1.09e-08

Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarization-specific docking factor.


Pssm-ID: 400783  Cd Length: 113  Bit Score: 51.14  E-value: 1.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606575    9 VDIVSQFGMETVILHTALMLKKRIVV--YHPKIEAVQEFTRTLPALVWH----RQDWTILHSYVHLNadELEALQMCTGY 82
Cdd:pfam08616   5 LKLLGPFTPPIILLINALLTSKRIIFlsYQRSAGEVSEFVLALCNLISGgfvlRGFTNNSFPYVDLS--KLDALRKVPGY 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 733606575   83 VAGfvdleVSN-----RPDLYDVFVNLAESEITIAP 113
Cdd:pfam08616  83 IAG-----VTNpifenQDQWWDVLCDLDSGSVKLSK 113
 
Name Accession Description Interval E-value
SPA pfam08616
Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque ...
 9-113 1.09e-08

Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarization-specific docking factor.


Pssm-ID: 400783  Cd Length: 113  Bit Score: 51.14  E-value: 1.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733606575    9 VDIVSQFGMETVILHTALMLKKRIVV--YHPKIEAVQEFTRTLPALVWH----RQDWTILHSYVHLNadELEALQMCTGY 82
Cdd:pfam08616   5 LKLLGPFTPPIILLINALLTSKRIIFlsYQRSAGEVSEFVLALCNLISGgfvlRGFTNNSFPYVDLS--KLDALRKVPGY 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 733606575   83 VAGfvdleVSN-----RPDLYDVFVNLAESEITIAP 113
Cdd:pfam08616  83 IAG-----VTNpifenQDQWWDVLCDLDSGSVKLSK 113
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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