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Conserved domains on  [gi|733605735|ref|NP_001290048|]
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unique cartilage matrix-associated protein isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UCMA super family cl25314
Unique cartilage matrix associated protein; UCMA is a secreted cartilage-specific protein ...
 1-80 5.58e-35

Unique cartilage matrix associated protein; UCMA is a secreted cartilage-specific protein located in chromosome 2 that is predominantly expressed in resting chondrocytes. It is secreted into the extracellular matrix as an uncleaved precursor and shows the same restricted distribution pattern in cartilage as UCMA mRNA. This protein is proteolytically processed and contains tyrosine sulfates. It seems to be to be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of foetal cartilage.


The actual alignment was detected with superfamily member pfam17085:

Pssm-ID: 293690  Cd Length: 134  Bit Score: 115.46  E-value: 5.58e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733605735    1 MTWRQAVLLSCFSAVVLLSM------------------------------------------------------ENRQKL 26
Cdd:pfam17085   1 MSWTQPALLTCLLAVVALTLldggdsasvsdkrdavnpasegakrkifmqesdasnffkrrgkrspksqdeinaENRQRL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 733605735   27 RVDELRREYYEEQRNEFENFVEEQNDEQEERSREAVEQWRQWHYDGLHPSYLYN 80
Cdd:pfam17085  81 AADERRREYYEEQRNEFENYVEEENDEQEERSREKTEQWRQWHYDGLDPSYLYN 134
 
Name Accession Description Interval E-value
UCMA pfam17085
Unique cartilage matrix associated protein; UCMA is a secreted cartilage-specific protein ...
 1-80 5.58e-35

Unique cartilage matrix associated protein; UCMA is a secreted cartilage-specific protein located in chromosome 2 that is predominantly expressed in resting chondrocytes. It is secreted into the extracellular matrix as an uncleaved precursor and shows the same restricted distribution pattern in cartilage as UCMA mRNA. This protein is proteolytically processed and contains tyrosine sulfates. It seems to be to be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of foetal cartilage.


Pssm-ID: 293690  Cd Length: 134  Bit Score: 115.46  E-value: 5.58e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733605735    1 MTWRQAVLLSCFSAVVLLSM------------------------------------------------------ENRQKL 26
Cdd:pfam17085   1 MSWTQPALLTCLLAVVALTLldggdsasvsdkrdavnpasegakrkifmqesdasnffkrrgkrspksqdeinaENRQRL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 733605735   27 RVDELRREYYEEQRNEFENFVEEQNDEQEERSREAVEQWRQWHYDGLHPSYLYN 80
Cdd:pfam17085  81 AADERRREYYEEQRNEFENYVEEENDEQEERSREKTEQWRQWHYDGLDPSYLYN 134
 
Name Accession Description Interval E-value
UCMA pfam17085
Unique cartilage matrix associated protein; UCMA is a secreted cartilage-specific protein ...
 1-80 5.58e-35

Unique cartilage matrix associated protein; UCMA is a secreted cartilage-specific protein located in chromosome 2 that is predominantly expressed in resting chondrocytes. It is secreted into the extracellular matrix as an uncleaved precursor and shows the same restricted distribution pattern in cartilage as UCMA mRNA. This protein is proteolytically processed and contains tyrosine sulfates. It seems to be to be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of foetal cartilage.


Pssm-ID: 293690  Cd Length: 134  Bit Score: 115.46  E-value: 5.58e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 733605735    1 MTWRQAVLLSCFSAVVLLSM------------------------------------------------------ENRQKL 26
Cdd:pfam17085   1 MSWTQPALLTCLLAVVALTLldggdsasvsdkrdavnpasegakrkifmqesdasnffkrrgkrspksqdeinaENRQRL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 733605735   27 RVDELRREYYEEQRNEFENFVEEQNDEQEERSREAVEQWRQWHYDGLHPSYLYN 80
Cdd:pfam17085  81 AADERRREYYEEQRNEFENYVEEENDEQEERSREKTEQWRQWHYDGLDPSYLYN 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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